ISCA1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: ISCA1 is a mitochondrial protein involved in the biogenesis and assembly of iron-sulfur clusters, which play a role in electron-transfer reactions (Cozar-Castellano et al., 2004 [PubMed 15262227]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1tricarboxylic acid cycle (GO:0006099)5.55922256
2NADH metabolic process (GO:0006734)5.00681436
3protein neddylation (GO:0045116)4.56943724
4succinate metabolic process (GO:0006105)4.54347299
5regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)4.54193558
6regulation of acyl-CoA biosynthetic process (GO:0050812)4.51418068
7regulation of coenzyme metabolic process (GO:0051196)4.16862882
8regulation of cofactor metabolic process (GO:0051193)4.16862882
9cell communication by electrical coupling involved in cardiac conduction (GO:0086064)4.11972209
10membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.99215652
11positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)3.97682459
12synaptic vesicle exocytosis (GO:0016079)3.95078163
13oxaloacetate metabolic process (GO:0006107)3.94706595
14regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)3.94630208
15positive regulation of mitochondrial fission (GO:0090141)3.91560995
16detection of calcium ion (GO:0005513)3.88454043
17regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO3.88079935
18synaptic vesicle docking involved in exocytosis (GO:0016081)3.85607178
19regulation of short-term neuronal synaptic plasticity (GO:0048172)3.81833756
20regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)3.78407244
21regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)3.61533960
22cullin deneddylation (GO:0010388)3.60861887
23cell communication by electrical coupling (GO:0010644)3.56804873
24regulation of cell communication by electrical coupling (GO:0010649)3.56354979
25positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.50875676
26vocalization behavior (GO:0071625)3.50788321
27activation of protein kinase A activity (GO:0034199)3.49942097
28synaptic vesicle maturation (GO:0016188)3.43665281
29glutamate secretion (GO:0014047)3.39442767
30oxidative phosphorylation (GO:0006119)3.38135598
31regulation of synaptic vesicle exocytosis (GO:2000300)3.37266658
32regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.35676905
33negative regulation of response to food (GO:0032096)3.35656454
34negative regulation of appetite (GO:0032099)3.35656454
35carnitine shuttle (GO:0006853)3.33507879
36regulation of synaptic vesicle transport (GO:1902803)3.31644325
37regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.30711399
38mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.30650974
39neuronal action potential propagation (GO:0019227)3.30252795
40protein deneddylation (GO:0000338)3.28538360
41regulation of membrane repolarization (GO:0060306)3.26330287
42protoporphyrinogen IX metabolic process (GO:0046501)3.21503335
43sarcoplasmic reticulum calcium ion transport (GO:0070296)3.19844128
44respiratory electron transport chain (GO:0022904)3.19770569
45striatum development (GO:0021756)3.15944746
46neurotransmitter secretion (GO:0007269)3.14824760
47regulation of sulfur metabolic process (GO:0042762)3.14803931
48cardiac muscle contraction (GO:0060048)3.14002354
49positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.13769452
50electron transport chain (GO:0022900)3.12865100
51regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)3.10542325
52regulation of synapse structural plasticity (GO:0051823)3.07661995
53regulation of glutamate receptor signaling pathway (GO:1900449)3.06711922
54regulation of relaxation of muscle (GO:1901077)3.06092391
55regulation of cAMP-dependent protein kinase activity (GO:2000479)3.04600869
56mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.04410159
57lysine catabolic process (GO:0006554)3.03928958
58lysine metabolic process (GO:0006553)3.03928958
59regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.00601386
60negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)2.99934190
61cell communication involved in cardiac conduction (GO:0086065)2.99480441
62negative regulation of heart rate (GO:0010459)2.97392085
63cardiac myofibril assembly (GO:0055003)2.97039957
64behavioral response to nicotine (GO:0035095)2.95731790
65membrane depolarization during action potential (GO:0086010)2.93568368
66regulation of calcium ion transmembrane transporter activity (GO:1901019)2.92100183
67regulation of calcium ion transmembrane transport (GO:1903169)2.92100183
68negative regulation of cytosolic calcium ion concentration (GO:0051481)2.91981789
69protoporphyrinogen IX biosynthetic process (GO:0006782)2.91389319
70establishment of protein localization to mitochondrial membrane (GO:0090151)2.89721767
71mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.89323172
72mitochondrial respiratory chain complex I assembly (GO:0032981)2.89323172
73NADH dehydrogenase complex assembly (GO:0010257)2.89323172
74neurotransmitter-gated ion channel clustering (GO:0072578)2.89174085
75fatty acid transmembrane transport (GO:1902001)2.88838884
76locomotory exploration behavior (GO:0035641)2.87925244
77neurotransmitter uptake (GO:0001504)2.87597763
78dopamine transport (GO:0015872)2.86351948
79response to pheromone (GO:0019236)2.83772930
80cardiac conduction (GO:0061337)2.83706739
81neuromuscular process controlling posture (GO:0050884)2.83353461
82positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.83067368
83aspartate family amino acid catabolic process (GO:0009068)2.82961126
84synaptic vesicle endocytosis (GO:0048488)2.80504670
852-oxoglutarate metabolic process (GO:0006103)2.80214813
86sarcomere organization (GO:0045214)2.79284409
87regulation of protein glycosylation (GO:0060049)2.79093736
88porphyrin-containing compound biosynthetic process (GO:0006779)2.78899935
89negative regulation of potassium ion transmembrane transport (GO:1901380)2.76123889
90protein localization to synapse (GO:0035418)2.75386525
91L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.74857408
92energy coupled proton transport, down electrochemical gradient (GO:0015985)2.74186679
93ATP synthesis coupled proton transport (GO:0015986)2.74186679
94cellular potassium ion homeostasis (GO:0030007)2.72805014
95negative regulation of potassium ion transmembrane transporter activity (GO:1901017)2.72288512
96carnitine transmembrane transport (GO:1902603)2.71988331
97ATP hydrolysis coupled proton transport (GO:0015991)2.71886182
98energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)2.71886182
99mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)2.71512891
100positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:19021102.71512891
101regulation of sodium ion transmembrane transporter activity (GO:2000649)2.68696900
102tetrapyrrole biosynthetic process (GO:0033014)2.68248664
103positive regulation of potassium ion transmembrane transport (GO:1901381)2.68181021
104neuron-neuron synaptic transmission (GO:0007270)2.67631069
105striated muscle contraction (GO:0006941)2.66819640
106myofibril assembly (GO:0030239)2.65846320
107gluconeogenesis (GO:0006094)2.65450695
108regulation of actin filament-based movement (GO:1903115)2.65290743
109glycine transport (GO:0015816)2.65060916
110negative regulation of cation channel activity (GO:2001258)2.64505544
111positive regulation of calcium ion transmembrane transporter activity (GO:1901021)2.64059400
112positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.63925164
113regulation of heart rate by cardiac conduction (GO:0086091)2.63596457
114ubiquinone biosynthetic process (GO:0006744)2.62944587
115regulation of cation channel activity (GO:2001257)2.62492260
116regulation of mitochondrial fission (GO:0090140)2.61920140
117amino-acid betaine transport (GO:0015838)2.61786196
118carnitine transport (GO:0015879)2.61786196
119ubiquinone metabolic process (GO:0006743)2.60379350
120relaxation of cardiac muscle (GO:0055119)2.59551164
121pyrimidine nucleobase catabolic process (GO:0006208)2.58775374
122negative regulation of calcium ion transmembrane transporter activity (GO:1901020)2.58694694
123negative regulation of calcium ion transmembrane transport (GO:1903170)2.58694694
124membrane repolarization during cardiac muscle cell action potential (GO:0086013)2.58265418
125regulation of cilium movement (GO:0003352)2.58169415
126C4-dicarboxylate transport (GO:0015740)2.57543704
127proline transport (GO:0015824)2.56850135
128respiratory chain complex IV assembly (GO:0008535)2.55337870
129chaperone-mediated protein transport (GO:0072321)2.53088393
130protein localization to cilium (GO:0061512)2.50925779
131negative regulation of phosphoprotein phosphatase activity (GO:0032515)2.50751902
132protein-cofactor linkage (GO:0018065)2.48472673
133cellular response to leptin stimulus (GO:0044320)2.47943393
134gamma-aminobutyric acid transport (GO:0015812)2.45944779
135water-soluble vitamin biosynthetic process (GO:0042364)2.45129715
136protein complex biogenesis (GO:0070271)2.44317656
137response to insecticide (GO:0017085)2.43807627
138behavioral response to cocaine (GO:0048148)2.42663056
139neuron cell-cell adhesion (GO:0007158)2.42344381
140amino acid salvage (GO:0043102)2.41532646
141L-methionine salvage (GO:0071267)2.41532646
142L-methionine biosynthetic process (GO:0071265)2.41532646
143inositol phosphate catabolic process (GO:0071545)2.41354135
144relaxation of smooth muscle (GO:0044557)2.36109524
145regulation of Golgi to plasma membrane protein transport (GO:0042996)2.35850282
146neurofilament cytoskeleton organization (GO:0060052)2.31690325
147epithelial cell differentiation involved in kidney development (GO:0035850)2.30352940
148maturation of 5.8S rRNA (GO:0000460)2.29083745
149mitochondrial respiratory chain complex assembly (GO:0033108)2.28971931
150regulation of mitochondrial membrane permeability involved in apoptotic process (GO:1902108)2.27153226
151regulation of clathrin-mediated endocytosis (GO:2000369)2.25556937
152negative regulation of neurotransmitter transport (GO:0051589)2.24700603
153response to leptin (GO:0044321)2.24561523
154protein localization to mitochondrion (GO:0070585)2.24021668
155inositol phosphate dephosphorylation (GO:0046855)2.23941152
156phosphorylated carbohydrate dephosphorylation (GO:0046838)2.23941152
157regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.23195355
158synaptic transmission, glutamatergic (GO:0035249)2.23170876
159regulation of glucokinase activity (GO:0033131)2.22994112
160regulation of hexokinase activity (GO:1903299)2.22994112
161positive regulation of mitochondrial calcium ion concentration (GO:0051561)2.21242950
162nucleobase catabolic process (GO:0046113)2.20806387
163regulation of sequestering of triglyceride (GO:0010889)2.20695712
164fatty acid elongation (GO:0030497)2.19542409
165protein targeting to mitochondrion (GO:0006626)2.18739883
166glycosphingolipid biosynthetic process (GO:0006688)2.17888876
167platelet dense granule organization (GO:0060155)2.17175728
168peptidyl-cysteine modification (GO:0018198)2.16710757

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.71036523
2GBX2_23144817_ChIP-Seq_PC3_Human3.26986263
3ESRRB_18555785_ChIP-Seq_MESCs_Mouse3.24669334
4SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.65317991
5SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.52808645
6PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.52166331
7E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.51446132
8REST_21632747_ChIP-Seq_MESCs_Mouse2.50882439
9HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.35893626
10FLI1_27457419_Chip-Seq_LIVER_Mouse2.33566972
11RARB_27405468_Chip-Seq_BRAIN_Mouse2.31983914
12FUS_26573619_Chip-Seq_HEK293_Human2.28052001
13SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.23299027
14DROSHA_22980978_ChIP-Seq_HELA_Human2.21800425
15MTF2_20144788_ChIP-Seq_MESCs_Mouse2.21058582
16REST_18959480_ChIP-ChIP_MESCs_Mouse2.18258061
17JARID2_20064375_ChIP-Seq_MESCs_Mouse2.16258220
18PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.14735126
19SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.12057839
20KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.09946362
21EZH2_18974828_ChIP-Seq_MESCs_Mouse2.07359385
22RNF2_18974828_ChIP-Seq_MESCs_Mouse2.07359385
23SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.04265688
24JARID2_20075857_ChIP-Seq_MESCs_Mouse2.00766717
25EWS_26573619_Chip-Seq_HEK293_Human1.98981212
26GABP_17652178_ChIP-ChIP_JURKAT_Human1.96666085
27HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.91054313
28EZH2_27294783_Chip-Seq_ESCs_Mouse1.90139364
29RBPJ_22232070_ChIP-Seq_NCS_Mouse1.88584956
30SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.86326034
31EZH2_27304074_Chip-Seq_ESCs_Mouse1.84640413
32SUZ12_27294783_Chip-Seq_ESCs_Mouse1.80884885
33SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.76183158
34PCGF2_27294783_Chip-Seq_ESCs_Mouse1.75779959
35GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.70991559
36EED_16625203_ChIP-ChIP_MESCs_Mouse1.68283148
37CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.67117823
38OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.67040616
39* TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.64729561
40SALL1_21062744_ChIP-ChIP_HESCs_Human1.64577440
41FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.64570963
42SMAD4_21799915_ChIP-Seq_A2780_Human1.62076649
43NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.61644737
44ELK1_19687146_ChIP-ChIP_HELA_Human1.61613831
45TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.60279102
46AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.58125905
47EST1_17652178_ChIP-ChIP_JURKAT_Human1.52063195
48ZNF274_21170338_ChIP-Seq_K562_Hela1.49779474
49VDR_22108803_ChIP-Seq_LS180_Human1.49430637
50* PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.48123132
51CTBP2_25329375_ChIP-Seq_LNCAP_Human1.48026921
52GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.47983329
53CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.47608163
54EZH2_27294783_Chip-Seq_NPCs_Mouse1.46590999
55MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.46126341
56RNF2_27304074_Chip-Seq_ESCs_Mouse1.45989437
57EP300_21415370_ChIP-Seq_HL-1_Mouse1.45913877
58VDR_23849224_ChIP-Seq_CD4+_Human1.45140918
59RNF2_27304074_Chip-Seq_NSC_Mouse1.44463729
60TAF15_26573619_Chip-Seq_HEK293_Human1.44329719
61SUZ12_27294783_Chip-Seq_NPCs_Mouse1.40253277
62NR3C1_23031785_ChIP-Seq_PC12_Mouse1.40013519
63NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.38248226
64KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse1.37590257
65TP53_22573176_ChIP-Seq_HFKS_Human1.36913624
66SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.34525375
67ER_23166858_ChIP-Seq_MCF-7_Human1.34382315
68MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.33289667
69MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.31311092
70TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.30191305
71SOX2_21211035_ChIP-Seq_LN229_Gbm1.29703986
72P53_22387025_ChIP-Seq_ESCs_Mouse1.26765985
73NFE2_27457419_Chip-Seq_LIVER_Mouse1.25201196
74CTBP1_25329375_ChIP-Seq_LNCAP_Human1.24273822
75BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.23612397
76RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.23420101
77HTT_18923047_ChIP-ChIP_STHdh_Human1.23118227
78SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.22951949
79MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.22889650
80POU5F1_16153702_ChIP-ChIP_HESCs_Human1.22724727
81PIAS1_25552417_ChIP-Seq_VCAP_Human1.22387858
82CRX_20693478_ChIP-Seq_RETINA_Mouse1.22235788
83DNAJC2_21179169_ChIP-ChIP_NT2_Human1.22140239
84GATA1_22025678_ChIP-Seq_K562_Human1.21075668
85TAL1_26923725_Chip-Seq_HPCs_Mouse1.20526575
86NANOG_18555785_Chip-Seq_ESCs_Mouse1.20526009
87MYC_18940864_ChIP-ChIP_HL60_Human1.20474270
88EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.20295594
89PCGF2_27294783_Chip-Seq_NPCs_Mouse1.19948284
90FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.18720065
91NANOG_19829295_ChIP-Seq_ESCs_Human1.18189005
92SOX2_19829295_ChIP-Seq_ESCs_Human1.18189005
93* AR_25329375_ChIP-Seq_VCAP_Human1.15983278
94ZFP57_27257070_Chip-Seq_ESCs_Mouse1.15805076
95IKZF1_21737484_ChIP-ChIP_HCT116_Human1.15018363
96PADI4_21655091_ChIP-ChIP_MCF-7_Human1.13180621
97THAP11_20581084_ChIP-Seq_MESCs_Mouse1.13119008
98P300_19829295_ChIP-Seq_ESCs_Human1.12851559
99CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.11903313
100POU3F2_20337985_ChIP-ChIP_501MEL_Human1.11624172
101CREB1_15753290_ChIP-ChIP_HEK293T_Human1.11315568
102* GATA1_19941827_ChIP-Seq_MEL_Mouse1.10612263
103PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.10573495
104ETS1_20019798_ChIP-Seq_JURKAT_Human1.10570477
105IRF1_19129219_ChIP-ChIP_H3396_Human1.10452847
106CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.10393900
107E2F1_18555785_Chip-Seq_ESCs_Mouse1.10021973
108GATA1_19941826_ChIP-Seq_K562_Human1.09477953
109SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.08010657
110AR_21572438_ChIP-Seq_LNCaP_Human1.06939564
111AR_19668381_ChIP-Seq_PC3_Human1.06143258
112KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.05254814
113KLF5_20875108_ChIP-Seq_MESCs_Mouse1.05234011
114TOP2B_26459242_ChIP-Seq_MCF-7_Human1.04769549
115TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.04664730
116EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.04164649
117* SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.03789530
118FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.03526941
119IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.02657763
120CBP_20019798_ChIP-Seq_JUKART_Human1.02657763
121STAT3_23295773_ChIP-Seq_U87_Human1.02557150
122ERG_21242973_ChIP-ChIP_JURKAT_Human1.01914356
123EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.00370077
124TCF4_23295773_ChIP-Seq_U87_Human1.00319560
125RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.00258760
126CMYC_18555785_Chip-Seq_ESCs_Mouse1.00198343
127SRF_21415370_ChIP-Seq_HL-1_Mouse0.99445911
128TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse0.99415518
129IGF1R_20145208_ChIP-Seq_DFB_Human0.97941868
130CDX2_19796622_ChIP-Seq_MESCs_Mouse0.97776778
131STAT3_18555785_Chip-Seq_ESCs_Mouse0.97481296
132MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.97033170
133OCT4_21477851_ChIP-Seq_ESCs_Mouse0.96959404
134SOX2_16153702_ChIP-ChIP_HESCs_Human0.96889210
135CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.96641118
136SMAD3_21741376_ChIP-Seq_EPCs_Human0.96578976
137NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.96408828
138UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.93304800
139* SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.92982913
140THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.91644761
141EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.90319708
142BMI1_23680149_ChIP-Seq_NPCS_Mouse0.89426155
143PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.89359280
144TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.87931450
145EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.87367403
146CTCF_27219007_Chip-Seq_Bcells_Human0.86740990
147SMAD4_21741376_ChIP-Seq_HESCs_Human0.86691773
148BCAT_22108803_ChIP-Seq_LS180_Human0.86234223
149FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.85600428
150ESR1_20079471_ChIP-ChIP_T-47D_Human0.84342097
151CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.84091254
152P53_22127205_ChIP-Seq_FIBROBLAST_Human0.83781943
153WT1_25993318_ChIP-Seq_PODOCYTE_Human0.83463924
154KLF4_19829295_ChIP-Seq_ESCs_Human0.83094400
155YAP1_20516196_ChIP-Seq_MESCs_Mouse0.82739337
156BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.82091263
157FLI1_21867929_ChIP-Seq_TH2_Mouse0.81793090
158SMAD4_21741376_ChIP-Seq_EPCs_Human0.81535080
159RING1B_27294783_Chip-Seq_ESCs_Mouse0.81480375
160TBX20_22080862_ChIP-Seq_HEART_Mouse0.81459308
161TBX20_22328084_ChIP-Seq_HEART_Mouse0.81459308
162NR3C1_21868756_ChIP-Seq_MCF10A_Human0.80612145
163TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.78328897
164PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.77849155

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002837_dystrophic_cardiac_calcinosis4.23802597
2MP0003646_muscle_fatigue3.96801612
3MP0004859_abnormal_synaptic_plasticity3.77524967
4MP0004215_abnormal_myocardial_fiber3.23018955
5MP0000751_myopathy3.14176943
6MP0002102_abnormal_ear_morphology2.83205873
7MP0004147_increased_porphyrin_level2.81327496
8MP0003635_abnormal_synaptic_transmissio2.58207640
9MP0004036_abnormal_muscle_relaxation2.51792094
10MP0004084_abnormal_cardiac_muscle2.50865325
11MP0003880_abnormal_central_pattern2.50640083
12MP0008877_abnormal_DNA_methylation2.50428528
13MP0000749_muscle_degeneration2.43487116
14MP0004130_abnormal_muscle_cell2.42677549
15MP0002822_catalepsy2.38538434
16MP0009745_abnormal_behavioral_response2.23226169
17MP0004145_abnormal_muscle_electrophysio2.19779607
18MP0009046_muscle_twitch2.17200662
19MP0006036_abnormal_mitochondrial_physio2.13613584
20MP0001188_hyperpigmentation2.10763831
21MP0004484_altered_response_of1.98979094
22MP0002064_seizures1.98187764
23MP0002063_abnormal_learning/memory/cond1.97850034
24MP0003656_abnormal_erythrocyte_physiolo1.97527226
25MP0000013_abnormal_adipose_tissue1.96745062
26MP0004043_abnormal_pH_regulation1.93161887
27MP0002909_abnormal_adrenal_gland1.90161975
28MP0001968_abnormal_touch/_nociception1.86724058
29MP0004270_analgesia1.82114748
30MP0009780_abnormal_chondrocyte_physiolo1.81569499
31MP0005620_abnormal_muscle_contractility1.80968884
32MP0002736_abnormal_nociception_after1.78141944
33MP0001984_abnormal_olfaction1.78071411
34MP0005646_abnormal_pituitary_gland1.78061089
35MP0008775_abnormal_heart_ventricle1.73223800
36MP0005330_cardiomyopathy1.72111343
37MP0002272_abnormal_nervous_system1.72047518
38MP0002972_abnormal_cardiac_muscle1.67142839
39MP0009697_abnormal_copulation1.66109845
40MP0001501_abnormal_sleep_pattern1.62904028
41MP0002572_abnormal_emotion/affect_behav1.60077845
42MP0003137_abnormal_impulse_conducting1.58666761
43MP0004233_abnormal_muscle_weight1.57166488
44MP0004085_abnormal_heartbeat1.55067118
45MP0002734_abnormal_mechanical_nocicepti1.49262264
46MP0005670_abnormal_white_adipose1.46887687
47MP0003121_genomic_imprinting1.43372534
48MP0004924_abnormal_behavior1.43257391
49MP0005386_behavior/neurological_phenoty1.43257391
50MP0001486_abnormal_startle_reflex1.42651505
51MP0004087_abnormal_muscle_fiber1.42534587
52MP0002106_abnormal_muscle_physiology1.42311529
53MP0000747_muscle_weakness1.41825174
54MP0002269_muscular_atrophy1.41577410
55MP0005535_abnormal_body_temperature1.40003269
56MP0002067_abnormal_sensory_capabilities1.39646814
57MP0002332_abnormal_exercise_endurance1.38173559
58MP0003567_abnormal_fetal_cardiomyocyte1.36430646
59MP0001529_abnormal_vocalization1.35551358
60MP0000372_irregular_coat_pigmentation1.33176091
61MP0008569_lethality_at_weaning1.32927026
62MP0006035_abnormal_mitochondrial_morpho1.31334708
63MP0005499_abnormal_olfactory_system1.29653184
64MP0005394_taste/olfaction_phenotype1.29653184
65MP0003011_delayed_dark_adaptation1.29057460
66MP0003879_abnormal_hair_cell1.28544589
67MP0002735_abnormal_chemical_nociception1.28088254
68MP0003122_maternal_imprinting1.26173790
69MP0005187_abnormal_penis_morphology1.24792391
70MP0005083_abnormal_biliary_tract1.23520724
71MP0000569_abnormal_digit_pigmentation1.20605558
72MP0005385_cardiovascular_system_phenoty1.19391694
73MP0001544_abnormal_cardiovascular_syste1.19391694
74MP0003186_abnormal_redox_activity1.17441844
75MP0005369_muscle_phenotype1.17195051
76MP0002653_abnormal_ependyma_morphology1.17185327
77MP0000759_abnormal_skeletal_muscle1.17126889
78MP0001440_abnormal_grooming_behavior1.16544718
79MP0008789_abnormal_olfactory_epithelium1.13760331
80MP0006138_congestive_heart_failure1.10697319
81MP0003221_abnormal_cardiomyocyte_apopto1.09604386
82MP0008961_abnormal_basal_metabolism1.06932672
83MP0003890_abnormal_embryonic-extraembry1.06212567
84MP0004133_heterotaxia1.06117891
85MP0008058_abnormal_DNA_repair1.05616880
86MP0002078_abnormal_glucose_homeostasis1.04987138
87MP0008995_early_reproductive_senescence1.04730323
88MP0001970_abnormal_pain_threshold1.04140837
89MP0005253_abnormal_eye_physiology1.01961488
90MP0003195_calcinosis1.01810806
91MP0004142_abnormal_muscle_tone1.00265827
92MP0003787_abnormal_imprinting0.99596003
93MP0000230_abnormal_systemic_arterial0.99346707
94MP0004811_abnormal_neuron_physiology0.99142887
95MP0005464_abnormal_platelet_physiology0.98184388
96MP0001765_abnormal_ion_homeostasis0.96940267
97MP0002733_abnormal_thermal_nociception0.95923640
98MP0006276_abnormal_autonomic_nervous0.94249182
99MP0005084_abnormal_gallbladder_morpholo0.93807868
100MP0002234_abnormal_pharynx_morphology0.92922388
101MP0002557_abnormal_social/conspecific_i0.92691530
102MP0001502_abnormal_circadian_rhythm0.90750368
103MP0000003_abnormal_adipose_tissue0.90743829
104MP0005551_abnormal_eye_electrophysiolog0.90333296
105MP0002876_abnormal_thyroid_physiology0.90332322
106MP0010386_abnormal_urinary_bladder0.89660084
107MP0001986_abnormal_taste_sensitivity0.88433410
108MP0002066_abnormal_motor_capabilities/c0.88025713
109MP0000778_abnormal_nervous_system0.87238551
110MP0005645_abnormal_hypothalamus_physiol0.86771152
111MP0000631_abnormal_neuroendocrine_gland0.86644201
112MP0001905_abnormal_dopamine_level0.86473384
113MP0006292_abnormal_olfactory_placode0.85708521
114MP0003633_abnormal_nervous_system0.85564746
115MP0008872_abnormal_physiological_respon0.84206705
116MP0002638_abnormal_pupillary_reflex0.83082243
117MP0000750_abnormal_muscle_regeneration0.81669720
118MP0001485_abnormal_pinna_reflex0.79982502
119MP0005423_abnormal_somatic_nervous0.78961658
120MP0005636_abnormal_mineral_homeostasis0.77972991
121MP0002184_abnormal_innervation0.77232066
122MP0003136_yellow_coat_color0.75692109
123MP0002971_abnormal_brown_adipose0.75555731
124MP0010630_abnormal_cardiac_muscle0.75024822
125MP0002882_abnormal_neuron_morphology0.74412349
126MP0005448_abnormal_energy_balance0.74122377
127MP0003329_amyloid_beta_deposits0.73995549
128MP0002069_abnormal_eating/drinking_beha0.73398439
129MP0005666_abnormal_adipose_tissue0.73208138
130MP0002127_abnormal_cardiovascular_syste0.72368531
131MP0005085_abnormal_gallbladder_physiolo0.70796046
132MP0003953_abnormal_hormone_level0.70661115

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)4.94974058
2Exercise-induced myalgia (HP:0003738)4.81727781
3Myoglobinuria (HP:0002913)4.16465070
4Sudden death (HP:0001699)3.89038715
5Exercise-induced muscle cramps (HP:0003710)3.67539979
6Abnormal mitochondria in muscle tissue (HP:0008316)3.58809729
7Calf muscle hypertrophy (HP:0008981)3.55831790
8Visual hallucinations (HP:0002367)3.55783948
9Febrile seizures (HP:0002373)3.39846240
10Acute necrotizing encephalopathy (HP:0006965)3.39319712
11Atonic seizures (HP:0010819)3.35972566
12Abnormality of pyruvate family amino acid metabolism (HP:0010915)3.35205239
13Abnormality of alanine metabolism (HP:0010916)3.35205239
14Hyperalaninemia (HP:0003348)3.35205239
15Muscle hypertrophy of the lower extremities (HP:0008968)3.34656652
16Myokymia (HP:0002411)3.21888213
17Nemaline bodies (HP:0003798)3.19674223
18Bundle branch block (HP:0011710)3.15784020
19Acute encephalopathy (HP:0006846)3.13082506
20Ketoacidosis (HP:0001993)3.12902471
21Pheochromocytoma (HP:0002666)3.11745003
22Palpitations (HP:0001962)3.08007072
23Atrial fibrillation (HP:0005110)3.06276106
24Hepatic necrosis (HP:0002605)3.03635419
25Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.99307281
26Oligomenorrhea (HP:0000876)2.98663991
27Progressive macrocephaly (HP:0004481)2.95528013
28Epileptic encephalopathy (HP:0200134)2.93949792
29Focal seizures (HP:0007359)2.91736756
30Syncope (HP:0001279)2.90882121
31Neuroendocrine neoplasm (HP:0100634)2.89493705
32Primary atrial arrhythmia (HP:0001692)2.86600147
33Hepatocellular necrosis (HP:0001404)2.84865580
34Abnormality of the calf musculature (HP:0001430)2.83217584
35Generalized tonic-clonic seizures (HP:0002069)2.81167337
36Absence seizures (HP:0002121)2.77674617
37Supraventricular tachycardia (HP:0004755)2.75088526
38Ventricular fibrillation (HP:0001663)2.73756327
39Rhabdomyolysis (HP:0003201)2.73597380
40Mitochondrial inheritance (HP:0001427)2.73213683
41Prolonged QT interval (HP:0001657)2.72516456
42Cholelithiasis (HP:0001081)2.70025762
43Lactic acidosis (HP:0003128)2.67825698
44Supraventricular arrhythmia (HP:0005115)2.67721213
45Abnormality of the heme biosynthetic pathway (HP:0010472)2.62626523
46Increased CSF lactate (HP:0002490)2.59842238
47Gout (HP:0001997)2.59181297
48Type II lissencephaly (HP:0007260)2.58047788
49Increased muscle lipid content (HP:0009058)2.56712457
50Anxiety (HP:0000739)2.56621469
51Central scotoma (HP:0000603)2.56298857
52Depression (HP:0000716)2.53163270
53Myotonia (HP:0002486)2.51553486
54Hypoglycemic coma (HP:0001325)2.48187966
55Limb dystonia (HP:0002451)2.46923274
56Abnormal EKG (HP:0003115)2.45885548
57Medial flaring of the eyebrow (HP:0010747)2.44371789
58Abnormal gallbladder morphology (HP:0012437)2.43533795
59Muscle stiffness (HP:0003552)2.41743260
60Dysmetric saccades (HP:0000641)2.41706805
61Hyperventilation (HP:0002883)2.41418903
62Ketosis (HP:0001946)2.41110056
63Rimmed vacuoles (HP:0003805)2.40833199
64Dialeptic seizures (HP:0011146)2.40366506
65Cerebral edema (HP:0002181)2.37381171
66Left ventricular hypertrophy (HP:0001712)2.36114327
673-Methylglutaconic aciduria (HP:0003535)2.34609233
68Heart block (HP:0012722)2.33264409
69Gait imbalance (HP:0002141)2.30710401
70Ragged-red muscle fibers (HP:0003200)2.28841788
71Increased intramyocellular lipid droplets (HP:0012240)2.27062309
72Impaired vibration sensation in the lower limbs (HP:0002166)2.24285300
73Metaphyseal dysplasia (HP:0100255)2.23723681
74Lissencephaly (HP:0001339)2.22149862
75Poor eye contact (HP:0000817)2.21902445
76Poikilocytosis (HP:0004447)2.21602715
77Impaired social interactions (HP:0000735)2.20396997
78Abnormal social behavior (HP:0012433)2.20396997
79Abnormality of fatty-acid metabolism (HP:0004359)2.20266891
80Abnormal gallbladder physiology (HP:0012438)2.20146216
81Cholecystitis (HP:0001082)2.20146216
82Decreased activity of mitochondrial respiratory chain (HP:0008972)2.18237476
83Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.18237476
84Asymmetric septal hypertrophy (HP:0001670)2.16444092
85Ventricular arrhythmia (HP:0004308)2.16036172
86EMG: myopathic abnormalities (HP:0003458)2.15306424
87Ventricular tachycardia (HP:0004756)2.14466116
88Hyperglycinemia (HP:0002154)2.14386204
89Polyphagia (HP:0002591)2.12335987
90Congenital primary aphakia (HP:0007707)2.11092497
91Exercise intolerance (HP:0003546)2.09690222
92Abnormal atrioventricular conduction (HP:0005150)2.09261397
93Lipoatrophy (HP:0100578)2.09131814
94Abnormality of the left ventricular outflow tract (HP:0011103)2.08730289
95Subaortic stenosis (HP:0001682)2.08730289
96Methylmalonic acidemia (HP:0002912)2.08691589
97Morphological abnormality of the pyramidal tract (HP:0002062)2.08119324
98Increased hepatocellular lipid droplets (HP:0006565)2.07187984
99Muscle fiber splitting (HP:0003555)2.07123992
100Urinary urgency (HP:0000012)2.06666758
101Papillary thyroid carcinoma (HP:0002895)2.06574274
102Abnormality of the labia minora (HP:0012880)2.06469203
103Dicarboxylic aciduria (HP:0003215)2.06054086
104Abnormality of dicarboxylic acid metabolism (HP:0010995)2.06054086
105Renal Fanconi syndrome (HP:0001994)2.04702249
106Athetosis (HP:0002305)2.04483560
107Nephrogenic diabetes insipidus (HP:0009806)2.03875178
108Broad-based gait (HP:0002136)2.03724303
109Abnormality of midbrain morphology (HP:0002418)2.03381295
110Molar tooth sign on MRI (HP:0002419)2.03381295
111Progressive cerebellar ataxia (HP:0002073)2.02813108
112Lipid accumulation in hepatocytes (HP:0006561)2.02674911
113Acanthocytosis (HP:0001927)2.02262848
114Neoplasm of the adrenal gland (HP:0100631)2.01408007
115Atrioventricular block (HP:0001678)1.99483233
116Tinnitus (HP:0000360)1.98636923
117Dilated cardiomyopathy (HP:0001644)1.97703541
118Hyperlipoproteinemia (HP:0010980)1.97590885
119Retinal dysplasia (HP:0007973)1.97396564
120Metabolic acidosis (HP:0001942)1.96117392
121Conjunctival hamartoma (HP:0100780)1.95646967
122Muscle fiber inclusion bodies (HP:0100299)1.95615006
123Cerebral hypomyelination (HP:0006808)1.95322584
124Abnormality of glycolysis (HP:0004366)1.93840099
125Increased serum pyruvate (HP:0003542)1.93840099
126Pancreatic cysts (HP:0001737)1.93656441
127Generalized aminoaciduria (HP:0002909)1.91086345
128Abnormality of serum amino acid levels (HP:0003112)1.90461054
129Progressive inability to walk (HP:0002505)1.90133456
130Hyperinsulinemic hypoglycemia (HP:0000825)1.89942836
131Insulin-resistant diabetes mellitus (HP:0000831)1.89752461
132Gaze-evoked nystagmus (HP:0000640)1.89569938
133Degeneration of the lateral corticospinal tracts (HP:0002314)1.87660267
134Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.87660267
135Delusions (HP:0000746)1.85901246
136Epileptiform EEG discharges (HP:0011182)1.82736840
137Abnormality of glycine metabolism (HP:0010895)1.82508447
138Abnormality of serine family amino acid metabolism (HP:0010894)1.82508447
139Hypsarrhythmia (HP:0002521)1.82477966
140Renal cortical cysts (HP:0000803)1.80729385
141Drooling (HP:0002307)1.80209730
142Hyperglycinuria (HP:0003108)1.80177379
143Thyroid carcinoma (HP:0002890)1.78507531
144Inability to walk (HP:0002540)1.76962754
145Genital tract atresia (HP:0001827)1.76349774
146EEG with generalized epileptiform discharges (HP:0011198)1.76107262
147Increased serum lactate (HP:0002151)1.74781890
148True hermaphroditism (HP:0010459)1.74504510
149Vaginal atresia (HP:0000148)1.73290203
150Hypomagnesemia (HP:0002917)1.72989164
151Abnormality of the corticospinal tract (HP:0002492)1.72935401
152Pancreatic islet-cell hyperplasia (HP:0004510)1.72872918
153Unsteady gait (HP:0002317)1.72691766
154Pancreatic fibrosis (HP:0100732)1.72569247
155Postnatal microcephaly (HP:0005484)1.69761790
156Leukodystrophy (HP:0002415)1.69583514
157Specific learning disability (HP:0001328)1.68229607
158Gonadotropin excess (HP:0000837)1.65669074
159Spastic gait (HP:0002064)1.65359321

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK43.28420944
2PDK33.28420944
3NTRK32.90131295
4TRIM282.87138429
5MAP3K122.81887060
6PINK12.50840206
7MAP4K22.45454165
8EPHA42.37622325
9MAP3K42.35770121
10MAP3K92.30977999
11OBSCN2.27892087
12PHKG22.24578026
13PHKG12.24578026
14BCKDK2.19987226
15MST42.18910765
16BCR2.18477891
17MAP2K72.17531932
18EIF2AK12.11505882
19MAP2K42.08466483
20LMTK22.07356355
21NEK12.06801417
22PDK21.99635719
23PRKD31.99323016
24ERBB31.95542361
25MARK11.92106055
26DAPK21.89476949
27TIE11.74912656
28TAOK31.73997302
29ARAF1.73795674
30INSRR1.73461056
31MINK11.67651749
32CSNK1G11.60254686
33MYLK1.59006484
34BMPR1B1.55724953
35DYRK21.45994175
36KSR21.45598099
37TRIB31.44572201
38CAMKK11.40332026
39DYRK31.39779305
40ZAK1.38244149
41CDK191.36983846
42CSNK1G21.36547222
43MUSK1.34868683
44SGK21.34619403
45TNIK1.27342246
46PKN21.26226513
47GRK51.24999717
48SGK2231.24848359
49SGK4941.24848359
50DAPK11.22758172
51CSNK1G31.22512814
52CASK1.21966680
53PRPF4B1.20337128
54PLK21.19345274
55CAMKK21.18461440
56PLK31.17881146
57NME11.17835442
58STK161.15760862
59TTN1.13178343
60STK381.12903887
61PTK2B1.12468376
62TAOK11.11167061
63NLK1.08465820
64EPHA31.06064591
65SGK31.05691954
66PBK1.04014548
67PAK61.03305618
68CCNB11.00351465
69MAP3K130.99727244
70GRK70.98592352
71CSNK1A1L0.98567049
72SRPK10.96647191
73CAMK10.92231628
74MKNK20.90729200
75CDK50.89520772
76ACVR1B0.89210566
77VRK10.88436711
78PDK10.88375987
79PRKCG0.87631186
80KSR10.86719513
81MAP2K10.84712661
82WNK40.84301796
83CAMK2A0.84152686
84TSSK60.83639413
85MAP3K10.83150728
86STK240.83050435
87MKNK10.83010168
88BRAF0.82625394
89GRK10.82059371
90WNK30.81191784
91MAPK120.80685016
92UHMK10.78659994
93BMPR20.78353468
94CAMK2D0.77943417
95TNK20.75396756
96PRKAA10.75211527
97PDPK10.74946195
98RPS6KA50.71361271
99SGK10.66859860
100EIF2AK30.66547379
101LIMK10.66462154
102NUAK10.66360593
103RPS6KA40.66341343
104MAPK130.64906111
105MAP3K70.63667195
106CAMK2G0.63652388
107PRKCH0.61637326
108ADRBK20.61397819
109CDK30.61386871
110RIPK40.60842982
111SIK30.60266443
112PIK3CA0.59919796
113MAPKAPK30.55019488
114RET0.52863759
115CAMK40.51525310
116NTRK20.50569542
117TAOK20.50440082
118MAP3K110.50312651
119DMPK0.50239068
120PAK30.48946588
121PKN10.48712900
122RIPK10.48584383
123AKT30.47724968
124PNCK0.47707324
125MAP3K50.47178671
126TEC0.46867767
127CDC70.46717814
128PIK3CG0.46631887
129TXK0.46132971
130PRKCE0.45730702
131PRKG10.45426931
132FER0.45231678
133OXSR10.45177897
134DYRK1B0.44997592
135CDC42BPA0.44453606
136PRKACG0.44422100
137PLK10.44242152
138PRKACA0.44136349
139STK40.43243435
140DYRK1A0.43190409
141MAP2K30.42629137
142FRK0.41161007
143PRKAA20.41141172
144CAMK2B0.40880162
145WEE10.40454395
146RPS6KA30.39969875
147CSNK1D0.39902398
148ADRBK10.33276717
149PLK40.31136504

Predicted pathways (KEGG)

RankGene SetZ-score
1Citrate cycle (TCA cycle)_Homo sapiens_hsa000204.66156363
22-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.69897376
3Synaptic vesicle cycle_Homo sapiens_hsa047212.58439755
4Propanoate metabolism_Homo sapiens_hsa006402.40669090
5Nicotine addiction_Homo sapiens_hsa050332.35476119
6Olfactory transduction_Homo sapiens_hsa047402.25727113
7Oxidative phosphorylation_Homo sapiens_hsa001902.24114923
8Cardiac muscle contraction_Homo sapiens_hsa042602.23556589
9Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.19711437
10Protein export_Homo sapiens_hsa030602.10658414
11Parkinsons disease_Homo sapiens_hsa050122.06795387
12Fatty acid elongation_Homo sapiens_hsa000621.94721858
13Collecting duct acid secretion_Homo sapiens_hsa049661.90710662
14GABAergic synapse_Homo sapiens_hsa047271.89432319
15Circadian entrainment_Homo sapiens_hsa047131.86570181
16Pyruvate metabolism_Homo sapiens_hsa006201.83216930
17Insulin secretion_Homo sapiens_hsa049111.80833666
18Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.76187279
19Morphine addiction_Homo sapiens_hsa050321.73852607
20Alzheimers disease_Homo sapiens_hsa050101.61208297
21Amphetamine addiction_Homo sapiens_hsa050311.60310350
22Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.59386982
23Carbon metabolism_Homo sapiens_hsa012001.55797470
24Fatty acid degradation_Homo sapiens_hsa000711.54204892
25Long-term potentiation_Homo sapiens_hsa047201.53866977
26Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.52521305
27Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.51478224
28Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.51012166
29Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.42117173
30Butanoate metabolism_Homo sapiens_hsa006501.41869646
31Salivary secretion_Homo sapiens_hsa049701.40064310
32Calcium signaling pathway_Homo sapiens_hsa040201.37114651
33Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.36559583
34Dopaminergic synapse_Homo sapiens_hsa047281.34014399
35Dilated cardiomyopathy_Homo sapiens_hsa054141.33924228
36Proteasome_Homo sapiens_hsa030501.33692449
37Aldosterone synthesis and secretion_Homo sapiens_hsa049251.32192808
38Glutamatergic synapse_Homo sapiens_hsa047241.30117865
39Fatty acid metabolism_Homo sapiens_hsa012121.29848950
40Renin secretion_Homo sapiens_hsa049241.27778420
41Taste transduction_Homo sapiens_hsa047421.27436866
42RNA degradation_Homo sapiens_hsa030181.26613453
43Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.26509392
44Huntingtons disease_Homo sapiens_hsa050161.25754963
45Glucagon signaling pathway_Homo sapiens_hsa049221.24392726
46Oxytocin signaling pathway_Homo sapiens_hsa049211.22916356
47Gastric acid secretion_Homo sapiens_hsa049711.18449546
48SNARE interactions in vesicular transport_Homo sapiens_hsa041301.17799246
49Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.16544221
50Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.13531776
51Steroid biosynthesis_Homo sapiens_hsa001001.13459671
52Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.12904108
53Cholinergic synapse_Homo sapiens_hsa047251.12717953
54Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.10923393
55Primary bile acid biosynthesis_Homo sapiens_hsa001201.09533617
56Alcoholism_Homo sapiens_hsa050341.06162271
57RNA polymerase_Homo sapiens_hsa030201.05944774
58cGMP-PKG signaling pathway_Homo sapiens_hsa040221.04196808
59Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.03625043
60Arginine and proline metabolism_Homo sapiens_hsa003301.01176544
61Vibrio cholerae infection_Homo sapiens_hsa051101.00063260
62Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.96606558
63Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.96448615
64Basal transcription factors_Homo sapiens_hsa030220.93674095
65cAMP signaling pathway_Homo sapiens_hsa040240.88905177
66Circadian rhythm_Homo sapiens_hsa047100.88380184
67Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.87635632
68Type II diabetes mellitus_Homo sapiens_hsa049300.84361047
69Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.83755431
70Pancreatic secretion_Homo sapiens_hsa049720.80790591
71Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.79666694
72Cocaine addiction_Homo sapiens_hsa050300.79465107
73Insulin signaling pathway_Homo sapiens_hsa049100.77685188
74Serotonergic synapse_Homo sapiens_hsa047260.75760448
75Purine metabolism_Homo sapiens_hsa002300.74969745
76Vascular smooth muscle contraction_Homo sapiens_hsa042700.72191641
77Tryptophan metabolism_Homo sapiens_hsa003800.71812561
78PPAR signaling pathway_Homo sapiens_hsa033200.71532006
79Gap junction_Homo sapiens_hsa045400.70434547
80Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.69550092
81Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.69169762
82Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.67757893
83Biosynthesis of amino acids_Homo sapiens_hsa012300.67497212
84Selenocompound metabolism_Homo sapiens_hsa004500.67356644
85GnRH signaling pathway_Homo sapiens_hsa049120.67350870
86RNA transport_Homo sapiens_hsa030130.67285283
87Linoleic acid metabolism_Homo sapiens_hsa005910.66796195
88Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.66605196
89Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.66100004
90Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.66038457
91Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.65815742
92Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.65676808
93Long-term depression_Homo sapiens_hsa047300.65157515
94Fructose and mannose metabolism_Homo sapiens_hsa000510.64314873
95Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.63345580
96Arginine biosynthesis_Homo sapiens_hsa002200.63320742
97Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.61913511
98Mismatch repair_Homo sapiens_hsa034300.60931101
99Metabolic pathways_Homo sapiens_hsa011000.60873997
100beta-Alanine metabolism_Homo sapiens_hsa004100.60188667
101Sulfur metabolism_Homo sapiens_hsa009200.58054985
102Bile secretion_Homo sapiens_hsa049760.57565969
103Adipocytokine signaling pathway_Homo sapiens_hsa049200.57224790
104Insulin resistance_Homo sapiens_hsa049310.56975116
105Phosphatidylinositol signaling system_Homo sapiens_hsa040700.55595636
106Longevity regulating pathway - mammal_Homo sapiens_hsa042110.55420956
107AMPK signaling pathway_Homo sapiens_hsa041520.55312724
108Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.54461999
109Galactose metabolism_Homo sapiens_hsa000520.52518180
110Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.52410470
111Fatty acid biosynthesis_Homo sapiens_hsa000610.52042964
112Pentose and glucuronate interconversions_Homo sapiens_hsa000400.51863358
113Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.51427642
114Steroid hormone biosynthesis_Homo sapiens_hsa001400.51386495
115Chemical carcinogenesis_Homo sapiens_hsa052040.51167475
116Starch and sucrose metabolism_Homo sapiens_hsa005000.50954959
117Glycerolipid metabolism_Homo sapiens_hsa005610.50482582
118Regulation of autophagy_Homo sapiens_hsa041400.49085609
119Carbohydrate digestion and absorption_Homo sapiens_hsa049730.49082510
120Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.48109322
121Estrogen signaling pathway_Homo sapiens_hsa049150.47986022
122mRNA surveillance pathway_Homo sapiens_hsa030150.47891416
123Peroxisome_Homo sapiens_hsa041460.46608799
124Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.44277192
125Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.43658306
126Phototransduction_Homo sapiens_hsa047440.43470837
127Thyroid hormone synthesis_Homo sapiens_hsa049180.38854572
128Oocyte meiosis_Homo sapiens_hsa041140.38741508
129Cysteine and methionine metabolism_Homo sapiens_hsa002700.37006275
130Nitrogen metabolism_Homo sapiens_hsa009100.35332311
131Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.35292808
132Maturity onset diabetes of the young_Homo sapiens_hsa049500.33560214
133Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.32737523

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