

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | proteasome assembly (GO:0043248) | 5.25926300 |
| 2 | protein neddylation (GO:0045116) | 4.74641531 |
| 3 | establishment of protein localization to mitochondrial membrane (GO:0090151) | 4.27298960 |
| 4 | pyrimidine deoxyribonucleotide catabolic process (GO:0009223) | 4.18691981 |
| 5 | cullin deneddylation (GO:0010388) | 4.14442281 |
| 6 | protein-cofactor linkage (GO:0018065) | 4.11768724 |
| 7 | pyrimidine deoxyribonucleotide metabolic process (GO:0009219) | 4.01311521 |
| 8 | mitochondrial respiratory chain complex I biogenesis (GO:0097031) | 3.93580021 |
| 9 | mitochondrial respiratory chain complex I assembly (GO:0032981) | 3.93580021 |
| 10 | NADH dehydrogenase complex assembly (GO:0010257) | 3.93580021 |
| 11 | protein deneddylation (GO:0000338) | 3.88610057 |
| 12 | tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388) | 3.77531062 |
| 13 | RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394) | 3.77531062 |
| 14 | protein complex biogenesis (GO:0070271) | 3.71782266 |
| 15 | rRNA modification (GO:0000154) | 3.67428140 |
| 16 | mitochondrial ATP synthesis coupled proton transport (GO:0042776) | 3.62285023 |
| 17 | mitochondrial electron transport, NADH to ubiquinone (GO:0006120) | 3.59767102 |
| 18 | respiratory chain complex IV assembly (GO:0008535) | 3.57721147 |
| 19 | iron-sulfur cluster assembly (GO:0016226) | 3.52035566 |
| 20 | metallo-sulfur cluster assembly (GO:0031163) | 3.52035566 |
| 21 | mitochondrial respiratory chain complex assembly (GO:0033108) | 3.51291489 |
| 22 | base-excision repair, AP site formation (GO:0006285) | 3.45174038 |
| 23 | chaperone-mediated protein transport (GO:0072321) | 3.44393647 |
| 24 | pyrimidine nucleotide catabolic process (GO:0006244) | 3.42740151 |
| 25 | L-methionine biosynthetic process from methylthioadenosine (GO:0019509) | 3.42568005 |
| 26 | negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436) | 3.37954989 |
| 27 | regulation of mitochondrial translation (GO:0070129) | 3.35254176 |
| 28 | positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437) | 3.25081680 |
| 29 | transcription elongation from RNA polymerase III promoter (GO:0006385) | 3.24586438 |
| 30 | termination of RNA polymerase III transcription (GO:0006386) | 3.24586438 |
| 31 | nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291) | 3.24264411 |
| 32 | histone mRNA metabolic process (GO:0008334) | 3.21982455 |
| 33 | protein targeting to mitochondrion (GO:0006626) | 3.21849445 |
| 34 | exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay | 3.21763004 |
| 35 | regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439) | 3.19405326 |
| 36 | chromatin remodeling at centromere (GO:0031055) | 3.19301234 |
| 37 | rRNA methylation (GO:0031167) | 3.17935023 |
| 38 | platelet dense granule organization (GO:0060155) | 3.14882824 |
| 39 | CENP-A containing nucleosome assembly (GO:0034080) | 3.14821176 |
| 40 | regulation of cellular amino acid metabolic process (GO:0006521) | 3.14750165 |
| 41 | ATP synthesis coupled proton transport (GO:0015986) | 3.13802897 |
| 42 | energy coupled proton transport, down electrochemical gradient (GO:0015985) | 3.13802897 |
| 43 | establishment of protein localization to mitochondrion (GO:0072655) | 3.11958840 |
| 44 | water-soluble vitamin biosynthetic process (GO:0042364) | 3.10071505 |
| 45 | intracellular protein transmembrane import (GO:0044743) | 3.08787220 |
| 46 | protein localization to mitochondrion (GO:0070585) | 3.08730649 |
| 47 | respiratory electron transport chain (GO:0022904) | 3.06418717 |
| 48 | deoxyribose phosphate biosynthetic process (GO:0046385) | 3.05278515 |
| 49 | 2-deoxyribonucleotide biosynthetic process (GO:0009265) | 3.05278515 |
| 50 | response to pheromone (GO:0019236) | 3.03568731 |
| 51 | DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00 | 3.02962230 |
| 52 | organelle disassembly (GO:1903008) | 3.01577115 |
| 53 | electron transport chain (GO:0022900) | 3.00589161 |
| 54 | signal transduction involved in mitotic cell cycle checkpoint (GO:0072413) | 2.99831411 |
| 55 | signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403) | 2.99831411 |
| 56 | signal transduction involved in mitotic DNA damage checkpoint (GO:1902402) | 2.99831411 |
| 57 | negative regulation of ubiquitin-protein transferase activity (GO:0051444) | 2.99473928 |
| 58 | negative regulation of ligase activity (GO:0051352) | 2.99473928 |
| 59 | cytochrome complex assembly (GO:0017004) | 2.98231805 |
| 60 | mitochondrial RNA metabolic process (GO:0000959) | 2.97249860 |
| 61 | L-methionine salvage (GO:0071267) | 2.96939705 |
| 62 | L-methionine biosynthetic process (GO:0071265) | 2.96939705 |
| 63 | amino acid salvage (GO:0043102) | 2.96939705 |
| 64 | preassembly of GPI anchor in ER membrane (GO:0016254) | 2.95686966 |
| 65 | intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400) | 2.93025835 |
| 66 | signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431) | 2.93025835 |
| 67 | anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:0 | 2.91677181 |
| 68 | DNA double-strand break processing (GO:0000729) | 2.91178622 |
| 69 | deoxyribonucleoside monophosphate metabolic process (GO:0009162) | 2.90491484 |
| 70 | positive regulation of ubiquitin-protein transferase activity (GO:0051443) | 2.89883855 |
| 71 | ubiquinone biosynthetic process (GO:0006744) | 2.87286799 |
| 72 | ubiquinone metabolic process (GO:0006743) | 2.87286186 |
| 73 | signal transduction involved in cell cycle checkpoint (GO:0072395) | 2.86885081 |
| 74 | mannosylation (GO:0097502) | 2.86026576 |
| 75 | signal transduction involved in DNA integrity checkpoint (GO:0072401) | 2.83987875 |
| 76 | signal transduction involved in DNA damage checkpoint (GO:0072422) | 2.83987875 |
| 77 | deoxyribonucleotide catabolic process (GO:0009264) | 2.83500054 |
| 78 | branched-chain amino acid catabolic process (GO:0009083) | 2.82609042 |
| 79 | positive regulation of mitochondrial fission (GO:0090141) | 2.82135912 |
| 80 | DNA deamination (GO:0045006) | 2.80257382 |
| 81 | spliceosomal snRNP assembly (GO:0000387) | 2.78647702 |
| 82 | histone exchange (GO:0043486) | 2.78394062 |
| 83 | positive regulation of ligase activity (GO:0051351) | 2.77170534 |
| 84 | deoxyribose phosphate catabolic process (GO:0046386) | 2.76663381 |
| 85 | regulation of mitotic spindle checkpoint (GO:1903504) | 2.76590884 |
| 86 | regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266) | 2.76590884 |
| 87 | negative regulation of DNA-dependent DNA replication (GO:2000104) | 2.72663759 |
| 88 | telomere maintenance via semi-conservative replication (GO:0032201) | 2.69697092 |
| 89 | 2-deoxyribonucleotide metabolic process (GO:0009394) | 2.69691481 |
| 90 | somatic hypermutation of immunoglobulin genes (GO:0016446) | 2.69604306 |
| 91 | somatic diversification of immune receptors via somatic mutation (GO:0002566) | 2.69604306 |
| 92 | deoxyribonucleotide biosynthetic process (GO:0009263) | 2.69531165 |
| 93 | oxidative phosphorylation (GO:0006119) | 2.67264726 |
| 94 | tetrapyrrole biosynthetic process (GO:0033014) | 2.67053334 |
| 95 | tRNA processing (GO:0008033) | 2.66693110 |
| 96 | protein K11-linked ubiquitination (GO:0070979) | 2.66287913 |
| 97 | deoxyribose phosphate metabolic process (GO:0019692) | 2.65815910 |
| 98 | regulation of cellular respiration (GO:0043457) | 2.63945972 |
| 99 | porphyrin-containing compound biosynthetic process (GO:0006779) | 2.63382040 |
| 100 | recombinational repair (GO:0000725) | 2.62958552 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human | 4.85276185 |
| 2 | GABP_17652178_ChIP-ChIP_JURKAT_Human | 4.54604182 |
| 3 | EST1_17652178_ChIP-ChIP_JURKAT_Human | 3.79703447 |
| 4 | JARID1A_20064375_ChIP-Seq_MESCs_Mouse | 3.47413773 |
| 5 | NOTCH1_17114293_ChIP-ChIP_T-ALL_Human | 3.43936249 |
| 6 | HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human | 3.21795636 |
| 7 | ETS1_20019798_ChIP-Seq_JURKAT_Human | 3.14929209 |
| 8 | CREB1_15753290_ChIP-ChIP_HEK293T_Human | 3.08574572 |
| 9 | VDR_23849224_ChIP-Seq_CD4+_Human | 2.93943711 |
| 10 | IGF1R_20145208_ChIP-Seq_DFB_Human | 2.72014567 |
| 11 | ZNF274_21170338_ChIP-Seq_K562_Hela | 2.66798166 |
| 12 | CHD1_19587682_ChIP-ChIP_MESCs_Mouse | 2.60297699 |
| 13 | E2F4_17652178_ChIP-ChIP_JURKAT_Human | 2.59442395 |
| 14 | FOXP3_21729870_ChIP-Seq_TREG_Human | 2.55075788 |
| 15 | ELF1_17652178_ChIP-ChIP_JURKAT_Human | 2.54144096 |
| 16 | ELK1_19687146_ChIP-ChIP_HELA_Human | 2.53703560 |
| 17 | MYC_18555785_ChIP-Seq_MESCs_Mouse | 2.50780911 |
| 18 | SRF_21415370_ChIP-Seq_HL-1_Mouse | 2.50005317 |
| 19 | MYCN_21190229_ChIP-Seq_SHEP-21N_Human | 2.49118593 |
| 20 | PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse | 2.46482342 |
| 21 | PDX1_19855005_ChIP-ChIP_MIN6_Mouse | 2.29267332 |
| 22 | E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse | 2.24377078 |
| 23 | EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse | 2.20827813 |
| 24 | HCFC1_20581084_ChIP-Seq_MESCs_Mouse | 2.20364618 |
| 25 | FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse | 2.17336647 |
| 26 | GABP_19822575_ChIP-Seq_HepG2_Human | 2.12529084 |
| 27 | MYC_18358816_ChIP-ChIP_MESCs_Mouse | 2.05432444 |
| 28 | DCP1A_22483619_ChIP-Seq_HELA_Human | 2.05270171 |
| 29 | THAP11_20581084_ChIP-Seq_MESCs_Mouse | 2.04158007 |
| 30 | PADI4_21655091_ChIP-ChIP_MCF-7_Human | 1.88527492 |
| 31 | MYC_19030024_ChIP-ChIP_MESCs_Mouse | 1.88495895 |
| 32 | HOXB4_20404135_ChIP-ChIP_EML_Mouse | 1.87351881 |
| 33 | E2F7_22180533_ChIP-Seq_HELA_Human | 1.82522379 |
| 34 | E2F1_18555785_ChIP-Seq_MESCs_Mouse | 1.80933705 |
| 35 | NELFA_20434984_ChIP-Seq_ESCs_Mouse | 1.71737487 |
| 36 | FLI1_27457419_Chip-Seq_LIVER_Mouse | 1.69482466 |
| 37 | POU3F2_20337985_ChIP-ChIP_501MEL_Human | 1.67119247 |
| 38 | FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human | 1.65999238 |
| 39 | EWS_26573619_Chip-Seq_HEK293_Human | 1.64330038 |
| 40 | VDR_22108803_ChIP-Seq_LS180_Human | 1.61660649 |
| 41 | MYC_18940864_ChIP-ChIP_HL60_Human | 1.58456219 |
| 42 | SOX9_22984422_ChIP-ChIP_TESTIS_Rat | 1.57121301 |
| 43 | IRF1_19129219_ChIP-ChIP_H3396_Human | 1.51382300 |
| 44 | NOTCH1_21737748_ChIP-Seq_TLL_Human | 1.47500197 |
| 45 | TAF15_26573619_Chip-Seq_HEK293_Human | 1.37482326 |
| 46 | CEBPB_23403033_ChIP-Seq_LIVER_Mouse | 1.36721644 |
| 47 | FUS_26573619_Chip-Seq_HEK293_Human | 1.35252425 |
| 48 | YY1_21170310_ChIP-Seq_MESCs_Mouse | 1.35060738 |
| 49 | BCL3_23251550_ChIP-Seq_MUSCLE_Mouse | 1.34783016 |
| 50 | YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse | 1.34695770 |
| 51 | MYCN_18555785_ChIP-Seq_MESCs_Mouse | 1.34610533 |
| 52 | EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human | 1.32318433 |
| 53 | TP53_22573176_ChIP-Seq_HFKS_Human | 1.31720113 |
| 54 | TTF2_22483619_ChIP-Seq_HELA_Human | 1.30336444 |
| 55 | GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 1.27555637 |
| 56 | ZFP42_18358816_ChIP-ChIP_MESCs_Mouse | 1.27359335 |
| 57 | CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human | 1.25848541 |
| 58 | CEBPA_23403033_ChIP-Seq_LIVER_Mouse | 1.25093609 |
| 59 | SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse | 1.22292755 |
| 60 | POU5F1_18358816_ChIP-ChIP_MESCs_Mouse | 1.19164753 |
| 61 | FLI1_20887958_ChIP-Seq_HPC-7_Mouse | 1.16123174 |
| 62 | E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human | 1.15361022 |
| 63 | POU5F1_18555785_ChIP-Seq_MESCs_Mouse | 1.14472520 |
| 64 | PCGF2_27294783_Chip-Seq_ESCs_Mouse | 1.12975993 |
| 65 | XRN2_22483619_ChIP-Seq_HELA_Human | 1.12740055 |
| 66 | KDM5A_27292631_Chip-Seq_BREAST_Human | 1.12299517 |
| 67 | MYC_19079543_ChIP-ChIP_MESCs_Mouse | 1.08102793 |
| 68 | ERG_20887958_ChIP-Seq_HPC-7_Mouse | 1.08008666 |
| 69 | MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human | 1.03389683 |
| 70 | E2F1_21310950_ChIP-Seq_MCF-7_Human | 1.01559973 |
| 71 | SFPI1_20887958_ChIP-Seq_HPC-7_Mouse | 1.01544537 |
| 72 | ZFX_18555785_ChIP-Seq_MESCs_Mouse | 0.99352815 |
| 73 | EGR1_23403033_ChIP-Seq_LIVER_Mouse | 0.97141186 |
| 74 | TFEB_21752829_ChIP-Seq_HELA_Human | 0.95975103 |
| 75 | ER_23166858_ChIP-Seq_MCF-7_Human | 0.95611082 |
| 76 | P300_19829295_ChIP-Seq_ESCs_Human | 0.94863687 |
| 77 | ASH2L_23239880_ChIP-Seq_MESCs_Mouse | 0.94798440 |
| 78 | TAL1_20887958_ChIP-Seq_HPC-7_Mouse | 0.94797908 |
| 79 | ELK1_22589737_ChIP-Seq_MCF10A_Human | 0.93952448 |
| 80 | SALL1_21062744_ChIP-ChIP_HESCs_Human | 0.93145372 |
| 81 | MYBL2_22936984_ChIP-ChIP_MESCs_Mouse | 0.93142817 |
| 82 | MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse | 0.92596427 |
| 83 | EZH2_27294783_Chip-Seq_NPCs_Mouse | 0.92268127 |
| 84 | PRDM5_23873026_ChIP-Seq_MEFs_Mouse | 0.91768195 |
| 85 | GATA1_22025678_ChIP-Seq_K562_Human | 0.91168019 |
| 86 | AR_20517297_ChIP-Seq_VCAP_Human | 0.90457155 |
| 87 | CEBPB_24764292_ChIP-Seq_MC3T3_Mouse | 0.88401729 |
| 88 | IRF4_20064451_ChIP-Seq_CD4+T_Mouse | 0.87360039 |
| 89 | CBP_20019798_ChIP-Seq_JUKART_Human | 0.87360039 |
| 90 | FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse | 0.87061377 |
| 91 | HNF4A_19761587_ChIP-ChIP_CACO-2_Human | 0.85970771 |
| 92 | NCOR_22424771_ChIP-Seq_293T_Human | 0.85218275 |
| 93 | ZFP57_27257070_Chip-Seq_ESCs_Mouse | 0.85113828 |
| 94 | CEBPA_26348894_ChIP-Seq_LIVER_Mouse | 0.85062453 |
| 95 | CTBP2_25329375_ChIP-Seq_LNCAP_Human | 0.84695974 |
| 96 | CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human | 0.84225326 |
| 97 | FOXA1_25329375_ChIP-Seq_VCAP_Human | 0.83783879 |
| 98 | FOXA1_27270436_Chip-Seq_PROSTATE_Human | 0.83783879 |
| 99 | FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human | 0.82930496 |
| 100 | * CTBP1_25329375_ChIP-Seq_LNCAP_Human | 0.82588298 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MP0004147_increased_porphyrin_level | 3.68439100 |
| 2 | MP0008058_abnormal_DNA_repair | 3.60771107 |
| 3 | MP0003806_abnormal_nucleotide_metabolis | 3.27476860 |
| 4 | MP0002102_abnormal_ear_morphology | 3.00285059 |
| 5 | MP0003656_abnormal_erythrocyte_physiolo | 2.84018025 |
| 6 | MP0006036_abnormal_mitochondrial_physio | 2.68696566 |
| 7 | MP0009697_abnormal_copulation | 2.65541970 |
| 8 | MP0010094_abnormal_chromosome_stability | 2.60997632 |
| 9 | MP0001529_abnormal_vocalization | 2.42604273 |
| 10 | MP0003186_abnormal_redox_activity | 2.41890363 |
| 11 | MP0003646_muscle_fatigue | 2.40107343 |
| 12 | MP0008877_abnormal_DNA_methylation | 2.35688851 |
| 13 | MP0003718_maternal_effect | 2.18623902 |
| 14 | MP0003880_abnormal_central_pattern | 2.15531615 |
| 15 | MP0000372_irregular_coat_pigmentation | 2.12955609 |
| 16 | MP0004957_abnormal_blastocyst_morpholog | 2.06232531 |
| 17 | MP0001764_abnormal_homeostasis | 2.05875468 |
| 18 | MP0002138_abnormal_hepatobiliary_system | 2.00823352 |
| 19 | MP0006035_abnormal_mitochondrial_morpho | 1.98331316 |
| 20 | MP0003693_abnormal_embryo_hatching | 1.98268679 |
| 21 | MP0006276_abnormal_autonomic_nervous | 1.87486742 |
| 22 | MP0005084_abnormal_gallbladder_morpholo | 1.83357091 |
| 23 | MP0008872_abnormal_physiological_respon | 1.82772180 |
| 24 | MP0003011_delayed_dark_adaptation | 1.82347369 |
| 25 | MP0009046_muscle_twitch | 1.80196283 |
| 26 | MP0002139_abnormal_hepatobiliary_system | 1.79593826 |
| 27 | MP0008057_abnormal_DNA_replication | 1.78558215 |
| 28 | MP0003111_abnormal_nucleus_morphology | 1.77913125 |
| 29 | MP0006292_abnormal_olfactory_placode | 1.76708414 |
| 30 | MP0008260_abnormal_autophagy | 1.73787824 |
| 31 | MP0005410_abnormal_fertilization | 1.70014580 |
| 32 | MP0003786_premature_aging | 1.63945568 |
| 33 | MP0008789_abnormal_olfactory_epithelium | 1.56054956 |
| 34 | MP0005083_abnormal_biliary_tract | 1.55809672 |
| 35 | MP0005646_abnormal_pituitary_gland | 1.55336506 |
| 36 | MP0006072_abnormal_retinal_apoptosis | 1.53814662 |
| 37 | MP0005075_abnormal_melanosome_morpholog | 1.46292527 |
| 38 | MP0005645_abnormal_hypothalamus_physiol | 1.46137001 |
| 39 | MP0002837_dystrophic_cardiac_calcinosis | 1.45746096 |
| 40 | MP0004215_abnormal_myocardial_fiber | 1.43286982 |
| 41 | MP0002736_abnormal_nociception_after | 1.37395763 |
| 42 | MP0009764_decreased_sensitivity_to | 1.37263975 |
| 43 | MP0005253_abnormal_eye_physiology | 1.31807490 |
| 44 | MP0002090_abnormal_vision | 1.29930324 |
| 45 | MP0004133_heterotaxia | 1.29873837 |
| 46 | MP0000358_abnormal_cell_content/ | 1.29494187 |
| 47 | MP0005551_abnormal_eye_electrophysiolog | 1.26326242 |
| 48 | MP0003077_abnormal_cell_cycle | 1.24581668 |
| 49 | MP0004142_abnormal_muscle_tone | 1.21731689 |
| 50 | MP0008995_early_reproductive_senescence | 1.20035001 |
| 51 | MP0005174_abnormal_tail_pigmentation | 1.19172567 |
| 52 | MP0008932_abnormal_embryonic_tissue | 1.18192175 |
| 53 | MP0004145_abnormal_muscle_electrophysio | 1.17794564 |
| 54 | MP0001905_abnormal_dopamine_level | 1.14477429 |
| 55 | MP0008875_abnormal_xenobiotic_pharmacok | 1.14024271 |
| 56 | MP0001929_abnormal_gametogenesis | 1.11078235 |
| 57 | MP0005636_abnormal_mineral_homeostasis | 1.09142410 |
| 58 | MP0003121_genomic_imprinting | 1.09041731 |
| 59 | MP0001545_abnormal_hematopoietic_system | 1.07831229 |
| 60 | MP0005397_hematopoietic_system_phenotyp | 1.07831229 |
| 61 | MP0005332_abnormal_amino_acid | 1.05045828 |
| 62 | MP0002210_abnormal_sex_determination | 1.04903776 |
| 63 | MP0002822_catalepsy | 1.04443644 |
| 64 | MP0006054_spinal_hemorrhage | 1.02496664 |
| 65 | MP0003698_abnormal_male_reproductive | 1.00931448 |
| 66 | MP0002254_reproductive_system_inflammat | 1.00153012 |
| 67 | MP0005647_abnormal_sex_gland | 0.98862109 |
| 68 | MP0003787_abnormal_imprinting | 0.96326123 |
| 69 | MP0000015_abnormal_ear_pigmentation | 0.95723270 |
| 70 | MP0000653_abnormal_sex_gland | 0.95614355 |
| 71 | MP0000749_muscle_degeneration | 0.94746060 |
| 72 | MP0000631_abnormal_neuroendocrine_gland | 0.93006110 |
| 73 | MP0001986_abnormal_taste_sensitivity | 0.91876634 |
| 74 | MP0005266_abnormal_metabolism | 0.90001305 |
| 75 | MP0002332_abnormal_exercise_endurance | 0.85895270 |
| 76 | MP0003195_calcinosis | 0.82693636 |
| 77 | MP0008007_abnormal_cellular_replicative | 0.82628576 |
| 78 | MP0001293_anophthalmia | 0.80144416 |
| 79 | MP0001145_abnormal_male_reproductive | 0.80045809 |
| 80 | MP0005394_taste/olfaction_phenotype | 0.79660729 |
| 81 | MP0005499_abnormal_olfactory_system | 0.79660729 |
| 82 | MP0001324_abnormal_eye_pigmentation | 0.79528605 |
| 83 | MP0002272_abnormal_nervous_system | 0.79343991 |
| 84 | MP0002234_abnormal_pharynx_morphology | 0.79132077 |
| 85 | MP0004782_abnormal_surfactant_physiolog | 0.79042702 |
| 86 | MP0002876_abnormal_thyroid_physiology | 0.75777039 |
| 87 | MP0000230_abnormal_systemic_arterial | 0.75745404 |
| 88 | MP0008775_abnormal_heart_ventricle | 0.74975611 |
| 89 | MP0005395_other_phenotype | 0.74887532 |
| 90 | MP0000639_abnormal_adrenal_gland | 0.73723401 |
| 91 | MP0001968_abnormal_touch/_nociception | 0.73552407 |
| 92 | MP0005408_hypopigmentation | 0.72750186 |
| 93 | MP0000516_abnormal_urinary_system | 0.72439010 |
| 94 | MP0005367_renal/urinary_system_phenotyp | 0.72439010 |
| 95 | MP0001119_abnormal_female_reproductive | 0.72071518 |
| 96 | MP0003567_abnormal_fetal_cardiomyocyte | 0.71411856 |
| 97 | MP0005319_abnormal_enzyme/_coenzyme | 0.70023128 |
| 98 | MP0005464_abnormal_platelet_physiology | 0.67179706 |
| 99 | MP0002095_abnormal_skin_pigmentation | 0.66509909 |
| 100 | MP0003221_abnormal_cardiomyocyte_apopto | 0.66242265 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Acute necrotizing encephalopathy (HP:0006965) | 4.62636374 |
| 2 | Acute encephalopathy (HP:0006846) | 4.28084499 |
| 3 | Abnormal mitochondria in muscle tissue (HP:0008316) | 4.26602365 |
| 4 | Progressive macrocephaly (HP:0004481) | 3.80050544 |
| 5 | Mitochondrial inheritance (HP:0001427) | 3.78513992 |
| 6 | 3-Methylglutaconic aciduria (HP:0003535) | 3.75986755 |
| 7 | Increased CSF lactate (HP:0002490) | 3.64884405 |
| 8 | Hepatocellular necrosis (HP:0001404) | 3.57422557 |
| 9 | Abnormality of the heme biosynthetic pathway (HP:0010472) | 3.45070223 |
| 10 | Methylmalonic aciduria (HP:0012120) | 3.43025584 |
| 11 | Abnormality of pyruvate family amino acid metabolism (HP:0010915) | 3.31089982 |
| 12 | Abnormality of alanine metabolism (HP:0010916) | 3.31089982 |
| 13 | Hyperalaninemia (HP:0003348) | 3.31089982 |
| 14 | Hepatic necrosis (HP:0002605) | 3.30831294 |
| 15 | Cerebral edema (HP:0002181) | 3.27693835 |
| 16 | Increased serum lactate (HP:0002151) | 3.10961160 |
| 17 | Abnormal activity of mitochondrial respiratory chain (HP:0011922) | 3.09541743 |
| 18 | Decreased activity of mitochondrial respiratory chain (HP:0008972) | 3.09541743 |
| 19 | Lactic acidosis (HP:0003128) | 3.02978463 |
| 20 | Delayed CNS myelination (HP:0002188) | 2.97119250 |
| 21 | Type I transferrin isoform profile (HP:0003642) | 2.87926567 |
| 22 | Progressive inability to walk (HP:0002505) | 2.74651642 |
| 23 | Methylmalonic acidemia (HP:0002912) | 2.68438527 |
| 24 | Reduced antithrombin III activity (HP:0001976) | 2.66032091 |
| 25 | Exercise intolerance (HP:0003546) | 2.61379094 |
| 26 | Increased serum pyruvate (HP:0003542) | 2.56189971 |
| 27 | Respiratory failure (HP:0002878) | 2.46585501 |
| 28 | Abnormal isoelectric focusing of serum transferrin (HP:0003160) | 2.45137354 |
| 29 | Abnormal protein N-linked glycosylation (HP:0012347) | 2.45137354 |
| 30 | Abnormal protein glycosylation (HP:0012346) | 2.45137354 |
| 31 | Abnormal glycosylation (HP:0012345) | 2.45137354 |
| 32 | Degeneration of anterior horn cells (HP:0002398) | 2.41982717 |
| 33 | Abnormality of the anterior horn cell (HP:0006802) | 2.41982717 |
| 34 | Lipid accumulation in hepatocytes (HP:0006561) | 2.38065189 |
| 35 | Increased hepatocellular lipid droplets (HP:0006565) | 2.37202633 |
| 36 | Hyperglycinemia (HP:0002154) | 2.37190325 |
| 37 | Microvesicular hepatic steatosis (HP:0001414) | 2.36961371 |
| 38 | Poikilocytosis (HP:0004447) | 2.36746991 |
| 39 | Paralysis (HP:0003470) | 2.36493636 |
| 40 | Lethargy (HP:0001254) | 2.32092629 |
| 41 | Cerebral hypomyelination (HP:0006808) | 2.31878315 |
| 42 | Renal Fanconi syndrome (HP:0001994) | 2.30937899 |
| 43 | Increased intramyocellular lipid droplets (HP:0012240) | 2.28877881 |
| 44 | Dyschromatopsia (HP:0007641) | 2.24827027 |
| 45 | Inability to walk (HP:0002540) | 2.16235980 |
| 46 | Dicarboxylic aciduria (HP:0003215) | 2.15618317 |
| 47 | Abnormality of dicarboxylic acid metabolism (HP:0010995) | 2.15618317 |
| 48 | Hypochromic microcytic anemia (HP:0004840) | 2.13313268 |
| 49 | Severe visual impairment (HP:0001141) | 2.13100630 |
| 50 | Thyroid-stimulating hormone excess (HP:0002925) | 2.12244769 |
| 51 | Optic disc pallor (HP:0000543) | 2.12226064 |
| 52 | Nephronophthisis (HP:0000090) | 2.06082619 |
| 53 | Aplasia/hypoplasia of the uterus (HP:0008684) | 2.05953262 |
| 54 | Abnormality of glycolysis (HP:0004366) | 2.05264352 |
| 55 | Exercise-induced muscle cramps (HP:0003710) | 2.03041468 |
| 56 | Abnormality of aromatic amino acid family metabolism (HP:0004338) | 2.02177513 |
| 57 | CNS demyelination (HP:0007305) | 1.99467615 |
| 58 | Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688) | 1.99378487 |
| 59 | Meckel diverticulum (HP:0002245) | 1.98307901 |
| 60 | Leukodystrophy (HP:0002415) | 1.97909285 |
| 61 | Aplasia/Hypoplasia of the uvula (HP:0010293) | 1.94347024 |
| 62 | Muscle abnormality related to mitochondrial dysfunction (HP:0003800) | 1.93385942 |
| 63 | Abnormality of long-chain fatty-acid metabolism (HP:0010964) | 1.92260565 |
| 64 | Pancreatic cysts (HP:0001737) | 1.92031861 |
| 65 | Abnormality of the pons (HP:0007361) | 1.91565107 |
| 66 | Increased muscle lipid content (HP:0009058) | 1.90770387 |
| 67 | Generalized aminoaciduria (HP:0002909) | 1.89811916 |
| 68 | Abnormality of serum amino acid levels (HP:0003112) | 1.88675499 |
| 69 | Abnormality of the ileum (HP:0001549) | 1.87741537 |
| 70 | Postnatal microcephaly (HP:0005484) | 1.85548988 |
| 71 | Gout (HP:0001997) | 1.85336016 |
| 72 | Tubulointerstitial nephritis (HP:0001970) | 1.84716346 |
| 73 | Atrophy/Degeneration involving motor neurons (HP:0007373) | 1.84493909 |
| 74 | Emotional lability (HP:0000712) | 1.84113567 |
| 75 | Hypoplasia of the fovea (HP:0007750) | 1.84062116 |
| 76 | Aplasia/Hypoplasia of the fovea (HP:0008060) | 1.84062116 |
| 77 | Abnormal number of erythroid precursors (HP:0012131) | 1.83398399 |
| 78 | Hypoplasia of the pons (HP:0012110) | 1.83203809 |
| 79 | Fibular aplasia (HP:0002990) | 1.82462168 |
| 80 | Delayed myelination (HP:0012448) | 1.82181342 |
| 81 | X-linked dominant inheritance (HP:0001423) | 1.81093520 |
| 82 | Nemaline bodies (HP:0003798) | 1.81040681 |
| 83 | Abolished electroretinogram (ERG) (HP:0000550) | 1.80838961 |
| 84 | Abnormality of the fovea (HP:0000493) | 1.80757041 |
| 85 | Abnormal gallbladder morphology (HP:0012437) | 1.78816618 |
| 86 | Hypoplasia of the uterus (HP:0000013) | 1.78245675 |
| 87 | Decreased central vision (HP:0007663) | 1.76499566 |
| 88 | Cholelithiasis (HP:0001081) | 1.76481062 |
| 89 | Metabolic acidosis (HP:0001942) | 1.72268390 |
| 90 | Chromsome breakage (HP:0040012) | 1.71977503 |
| 91 | Dyskinesia (HP:0100660) | 1.70984457 |
| 92 | Muscle fiber inclusion bodies (HP:0100299) | 1.69464046 |
| 93 | Glycosuria (HP:0003076) | 1.69309145 |
| 94 | Abnormality of urine glucose concentration (HP:0011016) | 1.69309145 |
| 95 | Ketosis (HP:0001946) | 1.68790470 |
| 96 | Type 2 muscle fiber atrophy (HP:0003554) | 1.68065048 |
| 97 | Short tibia (HP:0005736) | 1.66968605 |
| 98 | Aplastic anemia (HP:0001915) | 1.66914119 |
| 99 | Abnormality of the preputium (HP:0100587) | 1.66409333 |
| 100 | Type II lissencephaly (HP:0007260) | 1.66255922 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | TRIM28 | 3.20932353 |
| 2 | EIF2AK1 | 3.17218522 |
| 3 | MST4 | 2.95185945 |
| 4 | VRK2 | 2.68852862 |
| 5 | ZAK | 2.61422584 |
| 6 | WNK3 | 2.48173244 |
| 7 | PLK4 | 2.37171820 |
| 8 | BCR | 2.29117115 |
| 9 | PBK | 2.17408881 |
| 10 | BCKDK | 2.12408598 |
| 11 | STK16 | 1.96971524 |
| 12 | VRK1 | 1.93077751 |
| 13 | PLK3 | 1.92776972 |
| 14 | MAP4K2 | 1.90783623 |
| 15 | SRPK1 | 1.88053356 |
| 16 | NEK1 | 1.72695196 |
| 17 | BUB1 | 1.71273822 |
| 18 | CDC7 | 1.67053972 |
| 19 | EIF2AK3 | 1.66537227 |
| 20 | MUSK | 1.64928831 |
| 21 | CSNK1G3 | 1.59091849 |
| 22 | TXK | 1.53117456 |
| 23 | BRSK2 | 1.48483180 |
| 24 | SIK3 | 1.44281398 |
| 25 | DYRK3 | 1.43754079 |
| 26 | GRK1 | 1.42895891 |
| 27 | OBSCN | 1.35405600 |
| 28 | PLK2 | 1.34670435 |
| 29 | PHKG2 | 1.31418348 |
| 30 | PHKG1 | 1.31418348 |
| 31 | DYRK2 | 1.30712188 |
| 32 | TESK1 | 1.30075358 |
| 33 | MAP2K7 | 1.29327018 |
| 34 | CSNK1G1 | 1.26664629 |
| 35 | CSNK1G2 | 1.23590019 |
| 36 | CCNB1 | 1.21107799 |
| 37 | PLK1 | 1.20997914 |
| 38 | ERBB3 | 1.20768777 |
| 39 | MAP3K12 | 1.20489625 |
| 40 | NME1 | 1.18960733 |
| 41 | CSNK1A1L | 1.17668448 |
| 42 | NUAK1 | 1.17336008 |
| 43 | NME2 | 1.13790695 |
| 44 | CDK19 | 1.05682404 |
| 45 | PRKD3 | 1.05038409 |
| 46 | MAPK13 | 0.94488608 |
| 47 | EPHA3 | 0.93710223 |
| 48 | PIM2 | 0.90382119 |
| 49 | MKNK1 | 0.89744440 |
| 50 | WNK4 | 0.89713915 |
| 51 | CAMKK2 | 0.89225263 |
| 52 | PINK1 | 0.88247589 |
| 53 | WEE1 | 0.87004536 |
| 54 | RPS6KA5 | 0.86886796 |
| 55 | TESK2 | 0.86669692 |
| 56 | TSSK6 | 0.85530300 |
| 57 | LIMK1 | 0.81939146 |
| 58 | MAP3K5 | 0.79728136 |
| 59 | ADRBK2 | 0.77970279 |
| 60 | MAP3K4 | 0.77411040 |
| 61 | TTK | 0.76721614 |
| 62 | TAOK3 | 0.76453384 |
| 63 | GRK6 | 0.74869513 |
| 64 | PDK2 | 0.73481957 |
| 65 | IRAK1 | 0.72261120 |
| 66 | FRK | 0.69760212 |
| 67 | STK39 | 0.66802582 |
| 68 | ACVR1B | 0.64255872 |
| 69 | IKBKB | 0.61322850 |
| 70 | CHEK2 | 0.60279600 |
| 71 | BRSK1 | 0.58797880 |
| 72 | TLK1 | 0.57270133 |
| 73 | ATR | 0.57125101 |
| 74 | CSNK2A1 | 0.55460216 |
| 75 | RPS6KA4 | 0.55246419 |
| 76 | MINK1 | 0.53028158 |
| 77 | AURKB | 0.52264516 |
| 78 | EIF2AK2 | 0.51370327 |
| 79 | SCYL2 | 0.50688193 |
| 80 | PRKCE | 0.50463653 |
| 81 | CLK1 | 0.48787175 |
| 82 | CSNK2A2 | 0.47686363 |
| 83 | CSNK1A1 | 0.47041076 |
| 84 | PRKCI | 0.46256256 |
| 85 | CAMK2D | 0.45699782 |
| 86 | MYLK | 0.44023131 |
| 87 | FLT3 | 0.42552011 |
| 88 | INSRR | 0.42271068 |
| 89 | ATM | 0.40765559 |
| 90 | KDR | 0.39448000 |
| 91 | AURKA | 0.39073881 |
| 92 | ABL2 | 0.36620098 |
| 93 | BMPR1B | 0.35525723 |
| 94 | PIM1 | 0.32452891 |
| 95 | TIE1 | 0.31365798 |
| 96 | PTK2B | 0.31309381 |
| 97 | TEC | 0.30954049 |
| 98 | DAPK1 | 0.29695021 |
| 99 | PNCK | 0.29572227 |
| 100 | ADRBK1 | 0.29269715 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Proteasome_Homo sapiens_hsa03050 | 4.19499590 |
| 2 | Protein export_Homo sapiens_hsa03060 | 3.72511568 |
| 3 | Oxidative phosphorylation_Homo sapiens_hsa00190 | 3.01931239 |
| 4 | Parkinsons disease_Homo sapiens_hsa05012 | 2.75566612 |
| 5 | Mismatch repair_Homo sapiens_hsa03430 | 2.57718207 |
| 6 | RNA polymerase_Homo sapiens_hsa03020 | 2.47898277 |
| 7 | DNA replication_Homo sapiens_hsa03030 | 2.36273988 |
| 8 | Base excision repair_Homo sapiens_hsa03410 | 2.30108019 |
| 9 | Homologous recombination_Homo sapiens_hsa03440 | 2.17269115 |
| 10 | Fanconi anemia pathway_Homo sapiens_hsa03460 | 2.16260742 |
| 11 | Regulation of autophagy_Homo sapiens_hsa04140 | 2.05909394 |
| 12 | Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563 | 2.03303601 |
| 13 | Propanoate metabolism_Homo sapiens_hsa00640 | 1.99557525 |
| 14 | Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 | 1.98433073 |
| 15 | Basal transcription factors_Homo sapiens_hsa03022 | 1.94217681 |
| 16 | Pyrimidine metabolism_Homo sapiens_hsa00240 | 1.90992609 |
| 17 | Huntingtons disease_Homo sapiens_hsa05016 | 1.84343635 |
| 18 | Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130 | 1.81950276 |
| 19 | Nucleotide excision repair_Homo sapiens_hsa03420 | 1.80015350 |
| 20 | Non-homologous end-joining_Homo sapiens_hsa03450 | 1.70864354 |
| 21 | Fatty acid elongation_Homo sapiens_hsa00062 | 1.64558671 |
| 22 | RNA degradation_Homo sapiens_hsa03018 | 1.62753599 |
| 23 | Spliceosome_Homo sapiens_hsa03040 | 1.62611105 |
| 24 | Alzheimers disease_Homo sapiens_hsa05010 | 1.58040650 |
| 25 | Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 | 1.58010832 |
| 26 | RNA transport_Homo sapiens_hsa03013 | 1.55046272 |
| 27 | Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630 | 1.47036833 |
| 28 | Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 | 1.45115586 |
| 29 | Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072 | 1.43126706 |
| 30 | Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 | 1.41266367 |
| 31 | Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970 | 1.39562489 |
| 32 | Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 | 1.36384394 |
| 33 | One carbon pool by folate_Homo sapiens_hsa00670 | 1.34608150 |
| 34 | Ribosome_Homo sapiens_hsa03010 | 1.33430926 |
| 35 | Purine metabolism_Homo sapiens_hsa00230 | 1.32173218 |
| 36 | Phototransduction_Homo sapiens_hsa04744 | 1.30529184 |
| 37 | Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860 | 1.29056841 |
| 38 | Cysteine and methionine metabolism_Homo sapiens_hsa00270 | 1.27833173 |
| 39 | Folate biosynthesis_Homo sapiens_hsa00790 | 1.26962633 |
| 40 | Nitrogen metabolism_Homo sapiens_hsa00910 | 1.25100648 |
| 41 | Citrate cycle (TCA cycle)_Homo sapiens_hsa00020 | 1.22020148 |
| 42 | 2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210 | 1.18370514 |
| 43 | Sulfur metabolism_Homo sapiens_hsa00920 | 1.15847820 |
| 44 | SNARE interactions in vesicular transport_Homo sapiens_hsa04130 | 1.13487865 |
| 45 | Selenocompound metabolism_Homo sapiens_hsa00450 | 1.08814190 |
| 46 | Steroid biosynthesis_Homo sapiens_hsa00100 | 1.07027989 |
| 47 | Peroxisome_Homo sapiens_hsa04146 | 1.05702100 |
| 48 | Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400 | 1.05463273 |
| 49 | Collecting duct acid secretion_Homo sapiens_hsa04966 | 1.02368243 |
| 50 | Butanoate metabolism_Homo sapiens_hsa00650 | 1.00239959 |
| 51 | Cardiac muscle contraction_Homo sapiens_hsa04260 | 0.99085628 |
| 52 | Pyruvate metabolism_Homo sapiens_hsa00620 | 0.97258896 |
| 53 | Primary bile acid biosynthesis_Homo sapiens_hsa00120 | 0.95200259 |
| 54 | Glutathione metabolism_Homo sapiens_hsa00480 | 0.94983485 |
| 55 | p53 signaling pathway_Homo sapiens_hsa04115 | 0.94080064 |
| 56 | Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770 | 0.91382633 |
| 57 | Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623 | 0.85316256 |
| 58 | Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 | 0.85169069 |
| 59 | Carbon metabolism_Homo sapiens_hsa01200 | 0.85091802 |
| 60 | Sulfur relay system_Homo sapiens_hsa04122 | 0.83923964 |
| 61 | Cell cycle_Homo sapiens_hsa04110 | 0.82946684 |
| 62 | Metabolic pathways_Homo sapiens_hsa01100 | 0.82287901 |
| 63 | Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520 | 0.66761291 |
| 64 | Drug metabolism - other enzymes_Homo sapiens_hsa00983 | 0.66237664 |
| 65 | Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 | 0.65990313 |
| 66 | Oocyte meiosis_Homo sapiens_hsa04114 | 0.65329865 |
| 67 | Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 | 0.65064891 |
| 68 | Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010 | 0.64611942 |
| 69 | Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 | 0.62280045 |
| 70 | Biosynthesis of amino acids_Homo sapiens_hsa01230 | 0.61030990 |
| 71 | Chemical carcinogenesis_Homo sapiens_hsa05204 | 0.57757387 |
| 72 | Steroid hormone biosynthesis_Homo sapiens_hsa00140 | 0.54939633 |
| 73 | mRNA surveillance pathway_Homo sapiens_hsa03015 | 0.53177098 |
| 74 | Pentose and glucuronate interconversions_Homo sapiens_hsa00040 | 0.50344711 |
| 75 | Olfactory transduction_Homo sapiens_hsa04740 | 0.47894754 |
| 76 | Ubiquitin mediated proteolysis_Homo sapiens_hsa04120 | 0.46251686 |
| 77 | Maturity onset diabetes of the young_Homo sapiens_hsa04950 | 0.43102528 |
| 78 | beta-Alanine metabolism_Homo sapiens_hsa00410 | 0.42944920 |
| 79 | Circadian rhythm_Homo sapiens_hsa04710 | 0.42728866 |
| 80 | Pathogenic Escherichia coli infection_Homo sapiens_hsa05130 | 0.42571338 |
| 81 | Fatty acid metabolism_Homo sapiens_hsa01212 | 0.42505443 |
| 82 | Pentose phosphate pathway_Homo sapiens_hsa00030 | 0.40819097 |
| 83 | Tryptophan metabolism_Homo sapiens_hsa00380 | 0.39638788 |
| 84 | Ascorbate and aldarate metabolism_Homo sapiens_hsa00053 | 0.37541908 |
| 85 | Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 | 0.34227570 |
| 86 | Linoleic acid metabolism_Homo sapiens_hsa00591 | 0.34164716 |
| 87 | Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533 | 0.33833016 |
| 88 | N-Glycan biosynthesis_Homo sapiens_hsa00510 | 0.33512336 |
| 89 | Retinol metabolism_Homo sapiens_hsa00830 | 0.32443675 |
| 90 | Arachidonic acid metabolism_Homo sapiens_hsa00590 | 0.32048637 |
| 91 | Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604 | 0.31668072 |
| 92 | Ether lipid metabolism_Homo sapiens_hsa00565 | 0.31152858 |
| 93 | Taurine and hypotaurine metabolism_Homo sapiens_hsa00430 | 0.30842288 |
| 94 | Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040 | 0.28514550 |
| 95 | Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 | 0.27416638 |
| 96 | Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603 | 0.26668821 |
| 97 | Phenylalanine metabolism_Homo sapiens_hsa00360 | 0.25484208 |
| 98 | Fatty acid degradation_Homo sapiens_hsa00071 | 0.24845459 |
| 99 | Epstein-Barr virus infection_Homo sapiens_hsa05169 | 0.22776870 |
| 100 | Starch and sucrose metabolism_Homo sapiens_hsa00500 | 0.22406299 |

