ISCA2P1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1somatic diversification of immunoglobulins involved in immune response (GO:0002208)8.85556628
2isotype switching (GO:0045190)8.85556628
3somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)8.85556628
4sequestering of actin monomers (GO:0042989)7.82199122
5sulfur amino acid catabolic process (GO:0000098)6.85771773
6somatic recombination of immunoglobulin gene segments (GO:0016447)6.28374867
7reciprocal DNA recombination (GO:0035825)6.13239203
8reciprocal meiotic recombination (GO:0007131)6.13239203
9mismatch repair (GO:0006298)6.11472223
10protein neddylation (GO:0045116)5.64575241
11L-methionine biosynthetic process from methylthioadenosine (GO:0019509)5.47379120
12somatic diversification of immunoglobulins (GO:0016445)5.43932080
13regulation of inhibitory postsynaptic membrane potential (GO:0060080)5.31102519
14DNA damage response, detection of DNA damage (GO:0042769)5.06365430
15B cell activation involved in immune response (GO:0002312)4.90703956
16startle response (GO:0001964)4.67078610
17membrane hyperpolarization (GO:0060081)4.52602745
18L-methionine salvage (GO:0071267)4.49245725
19L-methionine biosynthetic process (GO:0071265)4.49245725
20amino acid salvage (GO:0043102)4.49245725
21mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.45324486
22gamma-aminobutyric acid signaling pathway (GO:0007214)4.42648279
23synaptic vesicle exocytosis (GO:0016079)4.17998695
24somatic diversification of immune receptors via germline recombination within a single locus (GO:0004.16374507
25somatic cell DNA recombination (GO:0016444)4.16374507
26righting reflex (GO:0060013)4.07934767
27response to histamine (GO:0034776)3.97190190
28postsynaptic membrane organization (GO:0001941)3.85931731
29peroxisome fission (GO:0016559)3.79989209
30somatic diversification of immune receptors (GO:0002200)3.73054747
31protein maturation by protein folding (GO:0022417)3.59566980
32proteasome assembly (GO:0043248)3.58327136
33positive regulation of guanylate cyclase activity (GO:0031284)3.56280460
34GTP biosynthetic process (GO:0006183)3.53435537
35respiratory electron transport chain (GO:0022904)3.51804525
36behavioral response to nicotine (GO:0035095)3.43985266
37electron transport chain (GO:0022900)3.41201871
38auditory behavior (GO:0031223)3.34900265
39regulation of guanylate cyclase activity (GO:0031282)3.33825644
40positive regulation of cGMP biosynthetic process (GO:0030828)3.30435819
41cofactor catabolic process (GO:0051187)3.28599168
42synaptic vesicle docking involved in exocytosis (GO:0016081)3.26801757
43chaperone-mediated protein transport (GO:0072321)3.25587509
44energy coupled proton transport, down electrochemical gradient (GO:0015985)3.21405379
45ATP synthesis coupled proton transport (GO:0015986)3.21405379
46regulation of cGMP biosynthetic process (GO:0030826)3.17614075
47vocalization behavior (GO:0071625)3.14524252
48UTP biosynthetic process (GO:0006228)3.14126366
49mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.12333795
50regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.11724317
51neuron cell-cell adhesion (GO:0007158)3.00349112
52anterior/posterior axis specification, embryo (GO:0008595)2.98527081
53positive regulation of cGMP metabolic process (GO:0030825)2.97298679
54protein K6-linked ubiquitination (GO:0085020)2.90568720
55presynaptic membrane assembly (GO:0097105)2.83164800
56regulation of cGMP metabolic process (GO:0030823)2.79757804
57methionine biosynthetic process (GO:0009086)2.79412806
58response to gravity (GO:0009629)2.74804968
59cilium movement (GO:0003341)2.72619858
60UTP metabolic process (GO:0046051)2.70328231
61DNA replication checkpoint (GO:0000076)2.69582009
62negative regulation of DNA metabolic process (GO:0051053)2.67380412
63myelination in peripheral nervous system (GO:0022011)2.65542567
64peripheral nervous system axon ensheathment (GO:0032292)2.65542567
65transcription elongation from RNA polymerase III promoter (GO:0006385)2.65463887
66termination of RNA polymerase III transcription (GO:0006386)2.65463887
67G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.65444126
68heart contraction (GO:0060047)2.64690076
69heart process (GO:0003015)2.64690076
70sulfur amino acid metabolic process (GO:0000096)2.63518723
71entrainment of circadian clock by photoperiod (GO:0043153)2.60685841
72positive regulation of neurological system process (GO:0031646)2.56497623
73DNA integration (GO:0015074)2.56372283
74protein-cofactor linkage (GO:0018065)2.54647787
75maternal behavior (GO:0042711)2.54634208
76regulation of DNA recombination (GO:0000018)2.54477794
77negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.52778254
78epithelial cilium movement (GO:0003351)2.51796954
79coenzyme catabolic process (GO:0009109)2.47702439
80regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)2.46244056
81positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.41871867
82positive regulation of neurotransmitter secretion (GO:0001956)2.39638403
83protein targeting to mitochondrion (GO:0006626)2.38412728
84guanosine-containing compound biosynthetic process (GO:1901070)2.37781569
85positive regulation of CREB transcription factor activity (GO:0032793)2.36823000
86methionine metabolic process (GO:0006555)2.36193158
87neuronal action potential (GO:0019228)2.35494509
88regulation of timing of cell differentiation (GO:0048505)2.35377167
89regulation of acyl-CoA biosynthetic process (GO:0050812)2.34755193
90regulation of calcium ion-dependent exocytosis (GO:0017158)2.34236130
91microtubule polymerization or depolymerization (GO:0031109)2.33821413
92mechanosensory behavior (GO:0007638)2.33679713
93cerebellar Purkinje cell layer development (GO:0021680)2.33338886
94regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:00033392.32443158
95regulation of transmission of nerve impulse (GO:0051969)2.32440241
96somatic hypermutation of immunoglobulin genes (GO:0016446)17.3933646
97somatic diversification of immune receptors via somatic mutation (GO:0002566)17.3933646
98regulation of helicase activity (GO:0051095)17.2063237
99determination of adult lifespan (GO:0008340)13.8100987
100negative regulation of DNA recombination (GO:0045910)10.6314234

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GABP_17652178_ChIP-ChIP_JURKAT_Human3.53510605
2TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.42111794
3ZNF263_19887448_ChIP-Seq_K562_Human3.41036794
4SCL_19346495_ChIP-Seq_HPC-7_Human3.02415782
5TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.93437638
6HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.89707118
7NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.73940745
8CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.54792950
9FOXM1_23109430_ChIP-Seq_U2OS_Human2.25624556
10CREB1_15753290_ChIP-ChIP_HEK293T_Human2.19756973
11ZFP42_18358816_ChIP-ChIP_MESCs_Mouse2.19067857
12EST1_17652178_ChIP-ChIP_JURKAT_Human2.11558848
13KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.04414126
14E2F7_22180533_ChIP-Seq_HELA_Human11.0658656
15TAF15_26573619_Chip-Seq_HEK293_Human1.99036851
16SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.98758010
17GBX2_23144817_ChIP-Seq_PC3_Human1.98645537
18HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.92695580
19POU5F1_16153702_ChIP-ChIP_HESCs_Human1.91708720
20TP53_16413492_ChIP-PET_HCT116_Human1.86012200
21NANOG_18555785_ChIP-Seq_MESCs_Mouse1.76289789
22POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.74352323
23STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.68187519
24ELK1_19687146_ChIP-ChIP_HELA_Human1.68060662
25SOX2_18555785_ChIP-Seq_MESCs_Mouse1.66100259
26GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.65245782
27ZNF274_21170338_ChIP-Seq_K562_Hela1.57704651
28CTBP2_25329375_ChIP-Seq_LNCAP_Human1.55559924
29EWS_26573619_Chip-Seq_HEK293_Human1.50857238
30SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.50616009
31SOX2_22085726_ChIP-Seq_NPCs_Mouse1.49364491
32BMI1_23680149_ChIP-Seq_NPCS_Mouse1.47618652
33CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.47386145
34ER_23166858_ChIP-Seq_MCF-7_Human1.46734803
35VDR_22108803_ChIP-Seq_LS180_Human1.43702604
36EZH2_22144423_ChIP-Seq_EOC_Human1.42903712
37MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.40780677
38YY1_21170310_ChIP-Seq_MESCs_Mouse1.40663824
39NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.39985560
40POU3F2_20337985_ChIP-ChIP_501MEL_Human1.38268720
41P300_19829295_ChIP-Seq_ESCs_Human1.36909218
42TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.30429280
43CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.26543445
44ZFP57_27257070_Chip-Seq_ESCs_Mouse1.26518379
45POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.22792871
46CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.22391251
47NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.20073877
48RNF2_27304074_Chip-Seq_NSC_Mouse1.18838958
49POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.18277619
50SOX2_16153702_ChIP-ChIP_HESCs_Human1.17861917
51NCOR_22424771_ChIP-Seq_293T_Human1.13016291
52IRF1_19129219_ChIP-ChIP_H3396_Human1.10388270
53UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.10025219
54AR_21572438_ChIP-Seq_LNCaP_Human1.08338812
55ELK1_22589737_ChIP-Seq_MCF10A_Human1.07846400
56RBPJ_21746931_ChIP-Seq_IB4_Human1.06804688
57PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.05798725
58FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.04818808
59GATA3_21878914_ChIP-Seq_MCF-7_Human1.04166568
60HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.04145224
61EZH2_27304074_Chip-Seq_ESCs_Mouse1.02050260
62ETV1_20927104_ChIP-Seq_GIST48_Human1.01218532
63PCGF4_22325352_ChIP-Seq_293T-Rex_Human1.00492446
64MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.00470257
65TOP2B_26459242_ChIP-Seq_MCF-7_Human1.00253396
66SALL1_21062744_ChIP-ChIP_HESCs_Human0.99604929
67PADI4_21655091_ChIP-ChIP_MCF-7_Human0.97460637
68SUZ12_18692474_ChIP-Seq_MESCs_Mouse0.97243884
69ERG_21242973_ChIP-ChIP_JURKAT_Human0.95661058
70RBPJ_22232070_ChIP-Seq_NCS_Mouse0.95102967
71JARID2_20064375_ChIP-Seq_MESCs_Mouse0.93524984
72CBX2_27304074_Chip-Seq_ESCs_Mouse0.92207911
73SMAD3_21741376_ChIP-Seq_EPCs_Human0.91353692
74SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.90520525
75SRF_21415370_ChIP-Seq_HL-1_Mouse0.90163382
76STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.89667134
77SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.89508607
78JARID1A_20064375_ChIP-Seq_MESCs_Mouse0.88317698
79CTBP1_25329375_ChIP-Seq_LNCAP_Human0.87632657
80TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.86890852
81POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.86890852
82PIAS1_25552417_ChIP-Seq_VCAP_Human0.86228650
83AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.85971783
84NOTCH1_17114293_ChIP-ChIP_T-ALL_Human0.85480917
85PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.84516518
86SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.83877315
87KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.83667648
88IRF8_21731497_ChIP-ChIP_J774_Mouse0.83558679
89CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.83362628
90GABP_19822575_ChIP-Seq_HepG2_Human0.81789909
91CDX2_21074721_ChIP-Seq_CACO-2_Mouse0.81579855
92TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.80598957
93MYC_18940864_ChIP-ChIP_HL60_Human0.80341144
94MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.79871866
95ERG_20517297_ChIP-Seq_VCAP_Human0.79687463
96TRIM28_21343339_ChIP-Seq_HEK293_Human0.79089503
97GATA6_21074721_ChIP-Seq_CACO-2_Human0.78912313
98DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.78840952
99PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.78649369
100EZH2_18974828_ChIP-Seq_MESCs_Mouse0.77955462

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004147_increased_porphyrin_level6.21417131
2MP0003566_abnormal_cell_adhesion4.52350179
3MP0008877_abnormal_DNA_methylation3.94803903
4MP0002736_abnormal_nociception_after3.47208752
5MP0003136_yellow_coat_color3.11005941
6MP0001968_abnormal_touch/_nociception3.04361165
7MP0004859_abnormal_synaptic_plasticity2.56420344
8MP0008875_abnormal_xenobiotic_pharmacok2.46536785
9MP0004270_analgesia2.40076327
10MP0003787_abnormal_imprinting2.36160378
11MP0001529_abnormal_vocalization2.31169508
12MP0003635_abnormal_synaptic_transmissio2.28583218
13MP0009745_abnormal_behavioral_response2.08411813
14MP0001440_abnormal_grooming_behavior2.07175253
15MP0001984_abnormal_olfaction2.01785138
16MP0002909_abnormal_adrenal_gland1.96481041
17MP0005423_abnormal_somatic_nervous1.81261590
18MP0002063_abnormal_learning/memory/cond1.77264010
19MP0002734_abnormal_mechanical_nocicepti1.76296110
20MP0002572_abnormal_emotion/affect_behav1.73834839
21MP0005083_abnormal_biliary_tract1.73564911
22MP0001905_abnormal_dopamine_level1.69650185
23MP0002638_abnormal_pupillary_reflex1.66379498
24MP0006072_abnormal_retinal_apoptosis1.64925870
25MP0004811_abnormal_neuron_physiology1.63800684
26MP0000372_irregular_coat_pigmentation1.59612062
27MP0000955_abnormal_spinal_cord1.49606702
28MP0002163_abnormal_gland_morphology1.49595431
29MP0005379_endocrine/exocrine_gland_phen1.46708209
30MP0002102_abnormal_ear_morphology1.42825835
31MP0002272_abnormal_nervous_system1.39854573
32MP0003137_abnormal_impulse_conducting1.35564910
33MP0004272_abnormal_basement_membrane1.34034333
34MP0002557_abnormal_social/conspecific_i1.33763463
35MP0003880_abnormal_central_pattern1.32558987
36MP0003186_abnormal_redox_activity1.29056439
37MP0003122_maternal_imprinting1.28017175
38MP0002067_abnormal_sensory_capabilities1.27565056
39MP0004924_abnormal_behavior1.27101641
40MP0005386_behavior/neurological_phenoty1.27101641
41MP0001191_abnormal_skin_condition1.26429164
42MP0002064_seizures1.22413073
43MP0003941_abnormal_skin_development1.18996158
44MP0004145_abnormal_muscle_electrophysio1.18802721
45MP0003724_increased_susceptibility_to1.14752496
46MP0002735_abnormal_chemical_nociception1.14271971
47MP0005187_abnormal_penis_morphology1.12595407
48MP0001970_abnormal_pain_threshold1.09624585
49MP0008872_abnormal_physiological_respon1.09003736
50MP0006276_abnormal_autonomic_nervous1.06676042
51MP0000639_abnormal_adrenal_gland1.06664368
52MP0003121_genomic_imprinting1.05867440
53MP0005551_abnormal_eye_electrophysiolog1.01611092
54MP0009046_muscle_twitch1.00809024
55MP0008770_decreased_survivor_rate0.93704459
56MP0004142_abnormal_muscle_tone0.91856251
57MP0005410_abnormal_fertilization0.91436508
58MP0005332_abnormal_amino_acid0.91305019
59MP0002132_abnormal_respiratory_system0.90940942
60MP0005075_abnormal_melanosome_morpholog0.90203297
61MP0000350_abnormal_cell_proliferation0.88449455
62MP0002269_muscular_atrophy0.88238267
63MP0002751_abnormal_autonomic_nervous0.87760693
64MP0002882_abnormal_neuron_morphology0.87533404
65MP0002184_abnormal_innervation0.84643132
66MP0004215_abnormal_myocardial_fiber0.84273834
67MP0003195_calcinosis0.83659077
68MP0001486_abnormal_startle_reflex0.82418591
69MP0002233_abnormal_nose_morphology0.80401038
70MP0002332_abnormal_exercise_endurance0.76097399
71MP0002972_abnormal_cardiac_muscle0.75861501
72MP0008874_decreased_physiological_sensi0.75713988
73MP0005647_abnormal_sex_gland0.74867061
74MP0002082_postnatal_lethality0.74805265
75MP0010770_preweaning_lethality0.74805265
76MP0000579_abnormal_nail_morphology0.72642395
77MP0010769_abnormal_survival0.72119666
78MP0010768_mortality/aging0.71213819
79MP0008057_abnormal_DNA_replication0.69261824
80MP0002160_abnormal_reproductive_system0.68968755
81MP0005636_abnormal_mineral_homeostasis0.67755617
82MP0005164_abnormal_response_to0.66763324
83MP0002069_abnormal_eating/drinking_beha0.65013671
84MP0002796_impaired_skin_barrier0.64578782
85MP0002066_abnormal_motor_capabilities/c0.64454913
86MP0002837_dystrophic_cardiac_calcinosis0.64029829
87MP0005448_abnormal_energy_balance0.63630584
88MP0002090_abnormal_vision0.63323524
89MP0008995_early_reproductive_senescence0.63231837
90MP0000762_abnormal_tongue_morphology0.63000624
91MP0005389_reproductive_system_phenotype0.62308548
92MP0000750_abnormal_muscle_regeneration0.61993649
93MP0000026_abnormal_inner_ear0.61953257
94MP0002210_abnormal_sex_determination0.61832673
95MP0008058_abnormal_DNA_repair0.61181629
96MP0003385_abnormal_body_wall0.60762860
97MP0000631_abnormal_neuroendocrine_gland0.60704813
98MP0003567_abnormal_fetal_cardiomyocyte0.58773903
99MP0003755_abnormal_palate_morphology0.57657118
100MP0005253_abnormal_eye_physiology0.57457632

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of the astrocytes (HP:0100707)8.73783313
2Astrocytoma (HP:0009592)8.73783313
3Medulloblastoma (HP:0002885)8.07410668
4Rhabdomyosarcoma (HP:0002859)7.83535659
5Biliary tract neoplasm (HP:0100574)6.88703219
6Glioma (HP:0009733)6.80669528
7Neoplasm of the oral cavity (HP:0100649)6.76065291
8Abnormality of the salivary glands (HP:0010286)6.24485228
9Angiofibromas (HP:0010615)5.47171445
10Adenoma sebaceum (HP:0009720)5.47171445
11Neoplasm of striated muscle (HP:0009728)5.36468099
12Neoplasm of the rectum (HP:0100743)5.09179013
13Amaurosis fugax (HP:0100576)4.96442293
14Basal cell carcinoma (HP:0002671)4.78916491
15Neoplasm of the small intestine (HP:0100833)4.44007887
16Neuroblastic tumors (HP:0004376)4.32272664
17Peripheral primitive neuroectodermal neoplasm (HP:0030067)4.32272664
18Neuroblastoma (HP:0003006)4.32272664
19Primitive neuroectodermal tumor (HP:0030065)4.32272664
20Hereditary nonpolyposis colorectal carcinoma (HP:0006716)3.81381200
21Abnormal biliary tract morphology (HP:0012440)3.69950676
22Atonic seizures (HP:0010819)3.66356306
23Neoplasm of the liver (HP:0002896)3.39895842
24Freckling (HP:0001480)3.06878925
25Malignant gastrointestinal tract tumors (HP:0006749)3.03561528
26Gastrointestinal carcinoma (HP:0002672)3.03561528
27Neoplasm of the colon (HP:0100273)2.80725430
28Oral leukoplakia (HP:0002745)2.76780174
29Febrile seizures (HP:0002373)2.76441514
30Fibroma (HP:0010614)2.71342118
31Fibrous tissue neoplasm (HP:0012316)2.66236574
32Neoplasm of the respiratory system (HP:0100606)2.61561646
33Intestinal polyposis (HP:0200008)2.59707821
34Nervous tissue neoplasm (HP:0030060)2.54794661
35Neuroectodermal neoplasm (HP:0030061)2.54794661
36Neuroepithelial neoplasm (HP:0030063)2.54794661
37Malignant neoplasm of the central nervous system (HP:0100836)2.47690352
38Cerebral hypomyelination (HP:0006808)2.47335159
39Benign neoplasm of the central nervous system (HP:0100835)2.46353581
40Respiratory difficulties (HP:0002880)2.43437618
41Focal seizures (HP:0007359)2.42989299
42Intestinal polyp (HP:0005266)2.41222384
43Generalized aminoaciduria (HP:0002909)2.37738132
44Neoplasm of the thyroid gland (HP:0100031)2.33265791
45Increased hepatocellular lipid droplets (HP:0006565)2.30822079
46Neoplasm of the pancreas (HP:0002894)2.30607379
47Uterine neoplasm (HP:0010784)2.26157772
48Lipid accumulation in hepatocytes (HP:0006561)2.24993727
49Short tibia (HP:0005736)2.16539854
50Memory impairment (HP:0002354)2.14274132
51Increased intracranial pressure (HP:0002516)2.10866098
52Abnormality of intracranial pressure (HP:0012640)2.10866098
53Aplasia/Hypoplasia of the tibia (HP:0005772)2.02152249
54Ovarian neoplasm (HP:0100615)2.01156322
55Focal motor seizures (HP:0011153)2.00353405
56Ependymoma (HP:0002888)12.2884813
57Agnosia (HP:0010524)12.2082669
58Supernumerary spleens (HP:0009799)1.96747000
59Absence seizures (HP:0002121)1.91969727
60Type II lissencephaly (HP:0007260)1.82455618
61Renal Fanconi syndrome (HP:0001994)1.82034653
62Ascites (HP:0001541)1.80868261
63CNS hypomyelination (HP:0003429)1.80520607
64Dialeptic seizures (HP:0011146)1.79354583
65Hypothermia (HP:0002045)1.79024517
66Abnormality of the phalanges of the hallux (HP:0010057)1.78091390
67Hepatic necrosis (HP:0002605)1.73658932
68Cerebellar dysplasia (HP:0007033)1.69671350
69Generalized tonic-clonic seizures (HP:0002069)1.65432932
70Increased intramyocellular lipid droplets (HP:0012240)1.59144714
71Abnormal ciliary motility (HP:0012262)1.57572305
72Hypoglycemic coma (HP:0001325)1.56792401
73Abnormal lung lobation (HP:0002101)1.55692174
74Complete atrioventricular canal defect (HP:0001674)1.48034693
75Hypermelanotic macule (HP:0001034)1.47157040
76Retinal atrophy (HP:0001105)1.42837187
77Abnormality of urine glucose concentration (HP:0011016)1.41485174
78Glycosuria (HP:0003076)1.41485174
79Increased muscle lipid content (HP:0009058)1.39914085
80Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)1.38563462
81Cafe-au-lait spot (HP:0000957)1.37360046
82Absent septum pellucidum (HP:0001331)1.35394199
83Paresthesia (HP:0003401)1.35082142
84Horizontal nystagmus (HP:0000666)1.34056053
85Abnormality of the labia minora (HP:0012880)1.33848257
86Exertional dyspnea (HP:0002875)1.32783942
87Cerebral palsy (HP:0100021)1.31818410
88Nausea (HP:0002018)1.31118183
89Aplasia/hypoplasia of the uterus (HP:0008684)1.29527980
90Premature ovarian failure (HP:0008209)1.28680478
91Hepatocellular necrosis (HP:0001404)1.26287254
92Abnormal respiratory motile cilium physiology (HP:0012261)1.25801439
93Atrioventricular canal defect (HP:0006695)1.24863120
94Poor suck (HP:0002033)1.22295531
95Abnormality of the septum pellucidum (HP:0007375)1.21819201
96Increased CSF lactate (HP:0002490)1.20751112
97Mitochondrial inheritance (HP:0001427)1.20497154
98Acute necrotizing encephalopathy (HP:0006965)1.19265800
99Retinal dysplasia (HP:0007973)1.17860051
100Renal cortical cysts (HP:0000803)1.15924850

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K26.95487832
2MST42.63087926
3SRPK12.46117474
4PDK22.42424730
5MAPK132.35932972
6DAPK22.29794479
7TLK12.07637244
8PAK411.0469064
9ARAF1.93890741
10ACVR1B1.64917851
11MARK11.52021821
12CASK1.48328035
13TRIM281.29195965
14CSNK1D1.25603621
15BCR1.24324892
16TTK1.11574736
17PIM21.05215240
18MAPK121.04746091
19TSSK61.02256650
20BUB10.97163211
21CCNB10.95786877
22EIF2AK10.95410891
23DYRK20.94222553
24TESK10.93521553
25MAPKAPK30.91221671
26TESK20.88680025
27PHKG20.85698863
28PHKG10.85698863
29DAPK10.85148900
30FLT30.78745539
31NME10.76424267
32RAF10.73506705
33CSNK1G30.71092998
34SIK30.69516721
35DYRK30.68453108
36PKN10.66421370
37PIK3CA0.66351488
38CSF1R0.66097090
39CSNK1A1L0.64905203
40CAMK2A0.63363390
41PRKCE0.62545837
42CSNK1G10.62337870
43TAOK30.60995780
44LIMK10.59364758
45TNIK0.59355512
46CAMK2B0.58815753
47DAPK30.58762153
48DYRK1B0.57783249
49BCKDK0.56861493
50CAMK2G0.56607895
51PLK40.54942201
52CSNK1G20.54088044
53PBK0.51883251
54EIF2AK30.50911705
55MAP2K70.50099750
56WNK30.48328330
57BLK0.45329144
58MATK0.45129758
59EEF2K0.45053308
60CLK10.44433983
61MAP3K40.43302260
62ZAK0.43246349
63MAPK40.42335289
64MAPKAPK50.41978345
65UHMK10.41575787
66VRK20.41166351
67CSNK2A20.40960846
68STK160.40520579
69FGFR10.39754275
70CDK180.39478304
71DYRK1A0.39008751
72NME20.36864822
73BMPR1B0.35555798
74VRK10.34460364
75CDK150.34150383
76PASK0.33542976
77OXSR10.32425960
78EIF2AK20.32039330
79PRKCG0.30696749
80LATS20.30659980
81MST1R0.29789361
82MET0.29709279
83ADRBK10.28541194
84INSRR0.27659103
85PAK60.27453150
86CAMK2D0.26940904
87SIK10.26676601
88ERBB30.26578997
89RPS6KA50.26383093
90CDK11A0.26307147
91TGFBR10.25487195
92ERBB40.25225792
93CSNK2A10.24873124
94PRKG20.23646401
95MKNK10.22597211
96KSR10.22491976
97BMX0.22122373
98OBSCN0.21814958
99CDK140.21482629
100PRKAA10.21324670

Predicted pathways (KEGG)

RankGene SetZ-score
1Taurine and hypotaurine metabolism_Homo sapiens_hsa004307.58652742
2Mismatch repair_Homo sapiens_hsa034306.50768618
3Nicotine addiction_Homo sapiens_hsa050333.82582155
4Ribosome_Homo sapiens_hsa030103.14800178
5Oxidative phosphorylation_Homo sapiens_hsa001902.80727765
6Parkinsons disease_Homo sapiens_hsa050122.67075773
7Taste transduction_Homo sapiens_hsa047422.13384838
8Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.07162187
9Alzheimers disease_Homo sapiens_hsa050102.06685229
10Cardiac muscle contraction_Homo sapiens_hsa042602.02631084
11RNA polymerase_Homo sapiens_hsa030201.99598394
12Huntingtons disease_Homo sapiens_hsa050161.94687728
13Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.88895231
14Morphine addiction_Homo sapiens_hsa050321.88184616
15GABAergic synapse_Homo sapiens_hsa047271.83195640
16Phototransduction_Homo sapiens_hsa047441.73380768
17Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.65200713
18Colorectal cancer_Homo sapiens_hsa052101.62389825
19Pyruvate metabolism_Homo sapiens_hsa006201.55027222
20Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.49932997
21Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.49852018
22Proteasome_Homo sapiens_hsa030501.42220479
23Renal cell carcinoma_Homo sapiens_hsa052111.38013019
24Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.17124775
25Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.10084414
262-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.09069422
27Axon guidance_Homo sapiens_hsa043601.06662830
28ErbB signaling pathway_Homo sapiens_hsa040121.04380184
29Glutamatergic synapse_Homo sapiens_hsa047241.00778034
30Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.99106572
31Serotonergic synapse_Homo sapiens_hsa047260.94705316
32Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.92875207
33Pyrimidine metabolism_Homo sapiens_hsa002400.86169283
34One carbon pool by folate_Homo sapiens_hsa006700.85794433
35Circadian entrainment_Homo sapiens_hsa047130.80136151
36Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.78643695
37Purine metabolism_Homo sapiens_hsa002300.76275305
38Vitamin B6 metabolism_Homo sapiens_hsa007500.75954090
39Propanoate metabolism_Homo sapiens_hsa006400.71976539
40Basal transcription factors_Homo sapiens_hsa030220.71275704
41Ras signaling pathway_Homo sapiens_hsa040140.68426854
42Protein export_Homo sapiens_hsa030600.67499211
43Spliceosome_Homo sapiens_hsa030400.66586438
44Phenylalanine metabolism_Homo sapiens_hsa003600.64400525
45MicroRNAs in cancer_Homo sapiens_hsa052060.62506889
46Pentose and glucuronate interconversions_Homo sapiens_hsa000400.60463028
47SNARE interactions in vesicular transport_Homo sapiens_hsa041300.58912849
48Tyrosine metabolism_Homo sapiens_hsa003500.56612524
49Chemical carcinogenesis_Homo sapiens_hsa052040.52785691
50Cocaine addiction_Homo sapiens_hsa050300.51131131
51Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.50403625
52Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.50213168
53Alcoholism_Homo sapiens_hsa050340.49413117
54Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.49300269
55Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.47934385
56RNA transport_Homo sapiens_hsa030130.46173706
57Cholinergic synapse_Homo sapiens_hsa047250.44347736
58Gap junction_Homo sapiens_hsa045400.43942718
59Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.43918064
60Nitrogen metabolism_Homo sapiens_hsa009100.40966394
61Fanconi anemia pathway_Homo sapiens_hsa034600.40951127
62Vitamin digestion and absorption_Homo sapiens_hsa049770.39338889
63Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.38056563
64Systemic lupus erythematosus_Homo sapiens_hsa053220.37895508
65Amphetamine addiction_Homo sapiens_hsa050310.37461954
66Metabolic pathways_Homo sapiens_hsa011000.35511763
67Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.35457465
68Glutathione metabolism_Homo sapiens_hsa004800.35102952
69Galactose metabolism_Homo sapiens_hsa000520.33436353
70Homologous recombination_Homo sapiens_hsa034400.31534353
71Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.27996729
72Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.26933550
73Arginine biosynthesis_Homo sapiens_hsa002200.26379056
74Peroxisome_Homo sapiens_hsa041460.24464978
75Drug metabolism - other enzymes_Homo sapiens_hsa009830.22632843
76Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.22111291
77Starch and sucrose metabolism_Homo sapiens_hsa005000.20148705
78Steroid hormone biosynthesis_Homo sapiens_hsa001400.19850908
79Retinol metabolism_Homo sapiens_hsa008300.19719099
80Legionellosis_Homo sapiens_hsa051340.19544542
81Olfactory transduction_Homo sapiens_hsa047400.18919958
82mRNA surveillance pathway_Homo sapiens_hsa030150.16541797
83Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.15534039
84Rheumatoid arthritis_Homo sapiens_hsa053230.15434309
85Salivary secretion_Homo sapiens_hsa049700.15105209
86Pathways in cancer_Homo sapiens_hsa052000.13535699
87Cyanoamino acid metabolism_Homo sapiens_hsa004600.13051589
88Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.13016658
89Dopaminergic synapse_Homo sapiens_hsa047280.12984278
90Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.12807664
91Synaptic vesicle cycle_Homo sapiens_hsa047210.12155229
92Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.11975195
93Melanoma_Homo sapiens_hsa052180.10879729
94Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.10743961
95Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.10096788
96Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.09770274
97Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.09148416
98Rap1 signaling pathway_Homo sapiens_hsa040150.08749947
99Regulation of actin cytoskeleton_Homo sapiens_hsa048100.08661153
100African trypanosomiasis_Homo sapiens_hsa051430.08312701

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