ISG15

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a ubiquitin-like protein that is conjugated to intracellular target proteins upon activation by interferon-alpha and interferon-beta. Several functions have been ascribed to the encoded protein, including chemotactic activity towards neutrophils, direction of ligated target proteins to intermediate filaments, cell-to-cell signaling, and antiviral activity during viral infections. While conjugates of this protein have been found to be noncovalently attached to intermediate filaments, this protein is sometimes secreted. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1antigen processing and presentation of endogenous peptide antigen (GO:0002483)6.10845729
2antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)6.10845729
3positive regulation of interferon-alpha production (GO:0032727)6.10629168
4regulation of interferon-alpha production (GO:0032647)5.79300299
5* cellular response to type I interferon (GO:0071357)5.77449430
6* type I interferon signaling pathway (GO:0060337)5.77449430
7* response to type I interferon (GO:0034340)5.74685492
8antigen processing and presentation of endogenous antigen (GO:0019883)5.73143714
9positive regulation of type I interferon-mediated signaling pathway (GO:0060340)5.40372637
10positive regulation by symbiont of host defense response (GO:0052509)5.29167419
11modulation by symbiont of host defense response (GO:0052031)5.29167419
12modulation by organism of immune response of other organism involved in symbiotic interaction (GO:005.29167419
13modulation by organism of defense response of other organism involved in symbiotic interaction (GO:05.29167419
14positive regulation by organism of defense response of other organism involved in symbiotic interact5.29167419
15modulation by symbiont of host immune response (GO:0052553)5.29167419
16response to interferon-alpha (GO:0035455)5.10414214
17regulation of chronic inflammatory response (GO:0002676)4.79516412
18immunoglobulin mediated immune response (GO:0016064)4.74713307
19response to peptidoglycan (GO:0032494)4.67705791
20regulation of vitamin D biosynthetic process (GO:0060556)4.64114575
21cellular response to virus (GO:0098586)4.62519164
22cellular response to interferon-alpha (GO:0035457)4.61963267
23antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.52828490
24* negative regulation of viral genome replication (GO:0045071)4.41551149
25interferon-gamma-mediated signaling pathway (GO:0060333)4.34343735
26response to interferon-beta (GO:0035456)4.30112784
27regulation of interferon-beta biosynthetic process (GO:0045357)4.27038814
28positive regulation of interferon-beta production (GO:0032728)4.25333546
29cellular response to interferon-beta (GO:0035458)4.22184302
30regulation of cytokine secretion involved in immune response (GO:0002739)4.16464138
31positive regulation of chemokine biosynthetic process (GO:0045080)4.15981511
32negative regulation of interleukin-12 production (GO:0032695)4.14238713
33regulation of T-helper 1 cell differentiation (GO:0045625)4.10650925
34lipopolysaccharide-mediated signaling pathway (GO:0031663)4.09814829
35regulation of type I interferon-mediated signaling pathway (GO:0060338)4.04742874
36neutrophil activation involved in immune response (GO:0002283)3.94827945
37response to host immune response (GO:0052572)3.93434384
38response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.93434384
39positive regulation of antigen processing and presentation (GO:0002579)3.91753046
40cellular response to exogenous dsRNA (GO:0071360)3.88815957
41negative regulation of cytokine production involved in immune response (GO:0002719)3.82627730
42* regulation of viral genome replication (GO:0045069)3.74088866
43macrophage activation involved in immune response (GO:0002281)3.71529222
44regulation of dendritic cell antigen processing and presentation (GO:0002604)3.69450569
45regulation of vitamin metabolic process (GO:0030656)3.68327047
46B cell mediated immunity (GO:0019724)3.59915988
47negative regulation of myeloid cell apoptotic process (GO:0033033)3.58634177
48cellular response to interferon-gamma (GO:0071346)3.58344427
49response to host (GO:0075136)3.50201291
50response to host defenses (GO:0052200)3.50201291
51response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.50201291
52positive regulation of defense response to virus by host (GO:0002230)3.49269521
53T cell migration (GO:0072678)3.48062703
54regulation of antigen processing and presentation (GO:0002577)3.47659403
55positive regulation of gamma-delta T cell activation (GO:0046645)3.46658061
56regulation of type 2 immune response (GO:0002828)3.45692476
57activation of MAPKKK activity (GO:0000185)3.43019856
58respiratory burst (GO:0045730)3.42075777
59regulation of chemokine biosynthetic process (GO:0045073)3.40098142
60response to muramyl dipeptide (GO:0032495)3.40072992
61positive regulation of interleukin-12 production (GO:0032735)3.37098918
62positive regulation of type 2 immune response (GO:0002830)3.36008881
63positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.35670569
64natural killer cell mediated immunity (GO:0002228)3.32657210
65natural killer cell mediated cytotoxicity (GO:0042267)3.32657210
66positive regulation of natural killer cell differentiation (GO:0032825)3.31521249
67T-helper 1 type immune response (GO:0042088)3.30504102
68branching involved in labyrinthine layer morphogenesis (GO:0060670)3.30436483
69response to interferon-gamma (GO:0034341)3.27546044
70positive regulation of toll-like receptor signaling pathway (GO:0034123)3.26834197
71germinal center formation (GO:0002467)3.24156152
72regulation of RIG-I signaling pathway (GO:0039535)3.22472079
73myeloid dendritic cell differentiation (GO:0043011)3.20546544
74regulation of immunoglobulin secretion (GO:0051023)3.20096739
75regulation of podosome assembly (GO:0071801)3.19514284
76positive regulation of interferon-gamma biosynthetic process (GO:0045078)3.19034987
77regulation of interferon-beta production (GO:0032648)3.17862371
78regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.17151769
79regulation of syncytium formation by plasma membrane fusion (GO:0060142)3.16888918
80dendritic cell differentiation (GO:0097028)3.16778401
81lymphocyte chemotaxis (GO:0048247)3.16454507
82granulocyte activation (GO:0036230)3.13429757
83hydrogen peroxide biosynthetic process (GO:0050665)3.11931531
84regulation of interleukin-12 biosynthetic process (GO:0045075)3.11183920
85positive regulation of NF-kappaB import into nucleus (GO:0042346)3.10707188
86NIK/NF-kappaB signaling (GO:0038061)3.10612607
87negative regulation of nitric oxide biosynthetic process (GO:0045019)3.08826463
88defense response to protozoan (GO:0042832)3.08741709
89regulation of mononuclear cell migration (GO:0071675)3.08338739
90JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)3.07894852
91regulation of T-helper cell differentiation (GO:0045622)3.05268293
92positive regulation of interleukin-8 biosynthetic process (GO:0045416)3.05196078
93microglial cell activation (GO:0001774)3.05012410
94regulation of defense response to virus by host (GO:0050691)3.03791497
95* defense response to virus (GO:0051607)3.03556835
96positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.03533305
97negative regulation of production of molecular mediator of immune response (GO:0002701)3.01834768
98positive regulation of heat generation (GO:0031652)3.01300658
99positive regulation of cytokine-mediated signaling pathway (GO:0001961)2.98678009
100eosinophil chemotaxis (GO:0048245)2.97546679
101interferon-gamma secretion (GO:0072643)2.97511621
102positive regulation of interleukin-17 production (GO:0032740)2.95300363
103positive regulation of humoral immune response (GO:0002922)2.93337631
104positive regulation of lymphocyte apoptotic process (GO:0070230)2.91295967
105myeloid dendritic cell activation (GO:0001773)2.90829854
106positive regulation of inflammatory response to antigenic stimulus (GO:0002863)2.90654962
107regulation of activation of Janus kinase activity (GO:0010533)2.90463023
108cellular response to lipopolysaccharide (GO:0071222)2.90309181
109regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway (GO:0039531)2.89554636
110regulation of interferon-gamma biosynthetic process (GO:0045072)2.89546600
111regulation of MHC class I biosynthetic process (GO:0045343)2.88688281
112CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)2.88235835
113negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.88185571
114negative regulation of cell killing (GO:0031342)2.88185571
115negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.87342384
116neutrophil activation (GO:0042119)2.87237791
117regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.86451091
118regulation of T-helper 2 cell differentiation (GO:0045628)2.86171276
119regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043370)2.85843410
120regulation of interleukin-12 production (GO:0032655)2.85328494
121* negative regulation of type I interferon production (GO:0032480)2.84508841
122regulation of fever generation (GO:0031620)2.84452964
123positive regulation of response to cytokine stimulus (GO:0060760)2.82836056
124myeloid cell activation involved in immune response (GO:0002275)2.82558299
125positive regulation of acute inflammatory response (GO:0002675)2.82502900
126negative regulation of inflammatory response to antigenic stimulus (GO:0002862)2.81096354
127cellular response to molecule of bacterial origin (GO:0071219)2.80676846
128positive regulation of cAMP-mediated signaling (GO:0043950)2.78421322
129* negative regulation of viral process (GO:0048525)2.78179108
130positive regulation of chemokine production (GO:0032722)2.77882584
131regulation of response to interferon-gamma (GO:0060330)2.77072556
132regulation of interleukin-17 production (GO:0032660)2.76869675
133response to protozoan (GO:0001562)2.76129583
134monocyte chemotaxis (GO:0002548)2.75730821
135response to exogenous dsRNA (GO:0043330)2.75722201
136low-density lipoprotein particle clearance (GO:0034383)2.75238536
137positive regulation of cytokine biosynthetic process (GO:0042108)2.74401969

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human8.30786224
2IRF8_21731497_ChIP-ChIP_J774_Mouse6.81399114
3* IRF1_21803131_ChIP-Seq_MONOCYTES_Human6.43179217
4IRF8_22096565_ChIP-ChIP_GC-B_Mouse5.14824383
5BP1_19119308_ChIP-ChIP_Hs578T_Human4.66585869
6* IRF8_27001747_Chip-Seq_BMDM_Mouse3.90503044
7FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.75065704
8RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human3.36456114
9* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.34861817
10* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse3.22102850
11STAT4_19710469_ChIP-ChIP_TH1__Mouse3.08716026
12STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.01239142
13STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.70944030
14MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.68983422
15EGR1_19374776_ChIP-ChIP_THP-1_Human2.62214903
16Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.61369838
17SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.46722993
18TP63_17297297_ChIP-ChIP_HaCaT_Human2.46679998
19MYB_21317192_ChIP-Seq_ERMYB_Mouse2.38397444
20NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.16605190
21STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse2.13504849
22NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.02930820
23THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.95934664
24STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.87899285
25GATA1_22025678_ChIP-Seq_K562_Human1.83587851
26TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.77903409
27BRD4_27068464_Chip-Seq_AML-cells_Mouse1.77880880
28* MAF_26560356_Chip-Seq_TH1_Human1.73836879
29MYB_26560356_Chip-Seq_TH2_Human1.61033176
30SPI1_23547873_ChIP-Seq_NB4_Human1.57954879
31CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.51625039
32TRIM28_21343339_ChIP-Seq_HEK293_Human1.51247090
33PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.49715070
34EGR1_23403033_ChIP-Seq_LIVER_Mouse1.49263248
35RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.46411839
36CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.45726046
37VDR_24763502_ChIP-Seq_THP-1_Human1.45492843
38PU_27001747_Chip-Seq_BMDM_Mouse1.39578933
39ESR2_21235772_ChIP-Seq_MCF-7_Human1.38230284
40RUNX_20019798_ChIP-Seq_JUKART_Human1.37367037
41* RUNX1_22412390_ChIP-Seq_EML_Mouse1.34816839
42FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.33656801
43MYB_26560356_Chip-Seq_TH1_Human1.32971834
44TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.31117818
45ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.29131030
46MYC_22102868_ChIP-Seq_BL_Human1.27160497
47SPI1_23127762_ChIP-Seq_K562_Human1.24883003
48VDR_24787735_ChIP-Seq_THP-1_Human1.21269692
49EGR1_19032775_ChIP-ChIP_M12_Human1.21061419
50TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.20260998
51GATA2_21666600_ChIP-Seq_HMVEC_Human1.19394747
52VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.18691205
53TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.17978520
54* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.17790537
55* RACK7_27058665_Chip-Seq_MCF-7_Human1.17376393
56CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.17189318
57CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.17185392
58VDR_21846776_ChIP-Seq_THP-1_Human1.15426773
59* ELK3_25401928_ChIP-Seq_HUVEC_Human1.11049197
60RARG_19884340_ChIP-ChIP_MEFs_Mouse1.10798600
61* UTX_26944678_Chip-Seq_JUKART_Human1.09817630
62SCL_19346495_ChIP-Seq_HPC-7_Human1.09053844
63PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.08830095
64SMAD_19615063_ChIP-ChIP_OVARY_Human1.08140922
65VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.07778434
66SRY_22984422_ChIP-ChIP_TESTIS_Rat1.07287846
67CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.06765152
68PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.04983649
69ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.04795606
70GATA2_22383799_ChIP-Seq_G1ME_Mouse1.04274834
71GATA3_27048872_Chip-Seq_THYMUS_Human1.02889055
72E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.01528794
73PPARA_22158963_ChIP-Seq_LIVER_Mouse1.00663426
74BCL6_27268052_Chip-Seq_Bcells_Human1.00588031
75GATA3_26560356_Chip-Seq_TH2_Human1.00284256
76STAT1_20625510_ChIP-Seq_HELA_Human1.00143501
77* SOX2_20726797_ChIP-Seq_SW620_Human0.99869053
78BCOR_27268052_Chip-Seq_Bcells_Human0.99763924
79* MAF_26560356_Chip-Seq_TH2_Human0.99605279
80FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.99160244
81PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.99113351
82RXR_22158963_ChIP-Seq_LIVER_Mouse0.98282691
83SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.97727465
84PU.1_20513432_ChIP-Seq_Bcells_Mouse0.95269424
85MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.94215289
86LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.93950518
87ESR1_21235772_ChIP-Seq_MCF-7_Human0.93756476
88STAT3_1855785_ChIP-Seq_MESCs_Mouse0.93678057
89HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.93061071
90SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.93000214
91GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.91668721
92CTCF_26484167_Chip-Seq_Bcells_Mouse0.90637264
93NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.88972867
94LXR_22158963_ChIP-Seq_LIVER_Mouse0.88814390
95* ELF1_20517297_ChIP-Seq_JURKAT_Human0.87448600
96ZNF263_19887448_ChIP-Seq_K562_Human0.87395399
97TFEB_21752829_ChIP-Seq_HELA_Human0.83406294
98CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.82601707
99* CTCF_27219007_Chip-Seq_ERYTHROID_Human0.81615988
100* TCF7_22412390_ChIP-Seq_EML_Mouse0.78804089
101* KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.78074100
102GATA1_19941827_ChIP-Seq_MEL_Mouse0.77792041
103FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.77086451
104ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.76675558
105P63_26484246_Chip-Seq_KERATINOCYTES_Human0.76654397
106TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.76193510
107IKZF1_21737484_ChIP-ChIP_HCT116_Human0.75932677
108* KDM2B_26808549_Chip-Seq_SUP-B15_Human0.75930719
109RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.74827864
110SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.74598207
111SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.74598207
112JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.74247248
113PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.74155128
114GATA1_22383799_ChIP-Seq_G1ME_Mouse0.73537260
115* LXR_22292898_ChIP-Seq_THP-1_Human0.70445124
116GATA2_19941826_ChIP-Seq_K562_Human0.69695814
117LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.67470256
118JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.66456197
119* KDM2B_26808549_Chip-Seq_DND41_Human0.66007416
120FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.63450951
121GATA1_19941826_ChIP-Seq_K562_Human0.63107406

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation4.50684688
2MP0009785_altered_susceptibility_to4.18552269
3MP0003436_decreased_susceptibility_to3.50434231
4MP0006082_CNS_inflammation3.44324198
5MP0003303_peritoneal_inflammation3.40782392
6MP0003724_increased_susceptibility_to3.36490955
7MP0002148_abnormal_hypersensitivity_rea3.32091245
8MP0004510_myositis3.16801548
9MP0005000_abnormal_immune_tolerance3.11219173
10MP0005025_abnormal_response_to3.11109090
11MP0005387_immune_system_phenotype3.08145802
12MP0001790_abnormal_immune_system3.08145802
13MP0000685_abnormal_immune_system3.01083961
14MP0005671_abnormal_response_to2.85467818
15MP0002419_abnormal_innate_immunity2.78995194
16MP0001800_abnormal_humoral_immune2.52341536
17MP0002452_abnormal_antigen_presenting2.51192695
18MP0002723_abnormal_immune_serum2.50525832
19MP0004947_skin_inflammation2.42749842
20MP0001819_abnormal_immune_cell2.15930471
21MP0001533_abnormal_skeleton_physiology2.14169245
22MP0002420_abnormal_adaptive_immunity2.10529838
23MP0009764_decreased_sensitivity_to2.07325469
24MP0002006_tumorigenesis2.05894726
25MP0005451_abnormal_body_composition2.01015325
26MP0003806_abnormal_nucleotide_metabolis1.97436031
27MP0005058_abnormal_lysosome_morphology1.95718606
28MP0002166_altered_tumor_susceptibility1.90269387
29MP0001853_heart_inflammation1.90095094
30MP0002139_abnormal_hepatobiliary_system1.88496015
31MP0010155_abnormal_intestine_physiology1.88145279
32MP0001845_abnormal_inflammatory_respons1.87341545
33MP0008469_abnormal_protein_level1.84524646
34MP0005464_abnormal_platelet_physiology1.82667201
35MP0009840_abnormal_foam_cell1.79451284
36MP0003448_altered_tumor_morphology1.79433924
37MP0000343_altered_response_to1.78604683
38MP0002332_abnormal_exercise_endurance1.76830873
39MP0002405_respiratory_system_inflammati1.72822694
40MP0008004_abnormal_stomach_pH1.72322262
41MP0006054_spinal_hemorrhage1.69160149
42MP0005310_abnormal_salivary_gland1.61020131
43MP0009333_abnormal_splenocyte_physiolog1.60532449
44MP0000716_abnormal_immune_system1.58724953
45MP0002398_abnormal_bone_marrow1.51173342
46MP0003075_altered_response_to1.50477181
47MP0003191_abnormal_cellular_cholesterol1.47502942
48MP0002138_abnormal_hepatobiliary_system1.44461206
49MP0009278_abnormal_bone_marrow1.42653070
50MP0004858_abnormal_nervous_system1.42550885
51MP0002998_abnormal_bone_remodeling1.36988349
52MP0000604_amyloidosis1.30576629
53MP0003300_gastrointestinal_ulcer1.29834204
54MP0000858_altered_metastatic_potential1.29458561
55MP0002429_abnormal_blood_cell1.26864509
56MP0003453_abnormal_keratinocyte_physiol1.25486141
57MP0002254_reproductive_system_inflammat1.24192490
58MP0005397_hematopoietic_system_phenotyp1.17941024
59MP0001545_abnormal_hematopoietic_system1.17941024
60MP0004782_abnormal_surfactant_physiolog1.17791454
61MP0000689_abnormal_spleen_morphology1.15256910
62MP0002722_abnormal_immune_system1.13962640
63MP0001542_abnormal_bone_strength1.13614843
64MP0003763_abnormal_thymus_physiology1.12484765
65MP0005164_abnormal_response_to1.12446243
66MP0010307_abnormal_tumor_latency1.09214169
67MP0002933_joint_inflammation1.08845977
68MP0005166_decreased_susceptibility_to1.07673266
69MP0009763_increased_sensitivity_to1.06106291
70MP0005390_skeleton_phenotype1.03324727
71MP0005023_abnormal_wound_healing1.02287551
72MP0003186_abnormal_redox_activity1.02087880
73MP0005167_abnormal_blood-brain_barrier1.01190567
74MP0003172_abnormal_lysosome_physiology1.00233612
75MP0005083_abnormal_biliary_tract0.93887999
76MP0002277_abnormal_respiratory_mucosa0.91485770
77MP0005076_abnormal_cell_differentiation0.91373101
78MP0010352_gastrointestinal_tract_polyps0.90503363
79MP0008438_abnormal_cutaneous_collagen0.89715859
80MP0001851_eye_inflammation0.89500159
81MP0003091_abnormal_cell_migration0.88676576
82MP0001873_stomach_inflammation0.85769771
83MP0008260_abnormal_autophagy0.84669304
84MP0000249_abnormal_blood_vessel0.82128316
85MP0003045_fibrosis0.79458012
86MP0008874_decreased_physiological_sensi0.78273241
87MP0003566_abnormal_cell_adhesion0.78192476
88MP0004883_abnormal_blood_vessel0.72797620
89MP0001348_abnormal_lacrimal_gland0.72556565
90MP0003656_abnormal_erythrocyte_physiolo0.71355105
91MP0002877_abnormal_melanocyte_morpholog0.69222050
92MP0001958_emphysema0.68430840
93MP0002136_abnormal_kidney_physiology0.66374179
94MP0003183_abnormal_peptide_metabolism0.65716146
95MP0003195_calcinosis0.65640636
96MP0003690_abnormal_glial_cell0.65630717
97MP0005266_abnormal_metabolism0.64448123
98MP0000920_abnormal_myelination0.63950305
99MP0003705_abnormal_hypodermis_morpholog0.63655251
100MP0000609_abnormal_liver_physiology0.62196450
101MP0005666_abnormal_adipose_tissue0.62173697
102MP0003795_abnormal_bone_structure0.61066267
103MP0004808_abnormal_hematopoietic_stem0.60924928
104MP0001881_abnormal_mammary_gland0.59190647
105MP0001501_abnormal_sleep_pattern0.59162036
106MP0005319_abnormal_enzyme/_coenzyme0.58971846
107MP0000703_abnormal_thymus_morphology0.58585354
108MP0003866_abnormal_defecation0.58512027
109MP0003828_pulmonary_edema0.55507881
110MP0001216_abnormal_epidermal_layer0.54557881
111MP0009765_abnormal_xenobiotic_induced0.54212060
112MP0001663_abnormal_digestive_system0.53371316
113MP0000490_abnormal_crypts_of0.52664968
114MP0000767_abnormal_smooth_muscle0.52453033
115MP0005165_increased_susceptibility_to0.52290677
116MP0005257_abnormal_intraocular_pressure0.51692129
117MP0003646_muscle_fatigue0.50956608
118MP0005535_abnormal_body_temperature0.50774001
119MP0002693_abnormal_pancreas_physiology0.50022617
120MP0005647_abnormal_sex_gland0.48353707

Predicted human phenotypes

RankGene SetZ-score
1Eczematoid dermatitis (HP:0000976)6.40441865
2Recurrent abscess formation (HP:0002722)5.71014401
3Elevated erythrocyte sedimentation rate (HP:0003565)5.62009878
4Recurrent bacterial skin infections (HP:0005406)5.33087129
5Chronic otitis media (HP:0000389)5.21363025
6Recurrent gram-negative bacterial infections (HP:0005420)5.00172608
7Autoimmune thrombocytopenia (HP:0001973)4.94193675
8Abnormality of macrophages (HP:0004311)4.54678946
9Increased IgM level (HP:0003496)4.53547115
10Orchitis (HP:0100796)4.44162710
11Myositis (HP:0100614)4.43174997
12Mediastinal lymphadenopathy (HP:0100721)4.24278513
13Stomatitis (HP:0010280)4.12107890
14Systemic lupus erythematosus (HP:0002725)4.11358557
15Retrobulbar optic neuritis (HP:0100654)3.94940854
16Optic neuritis (HP:0100653)3.94940854
17Nasal polyposis (HP:0100582)3.93784926
18Recurrent fungal infections (HP:0002841)3.89381026
19Vasculitis (HP:0002633)3.87669718
20Recurrent skin infections (HP:0001581)3.80912194
21Basal ganglia calcification (HP:0002135)3.78131666
22Abnormality of the nasal mucosa (HP:0000433)3.75629656
23Interstitial pulmonary disease (HP:0006530)3.70432573
24Recurrent viral infections (HP:0004429)3.68164878
25Disinhibition (HP:0000734)3.64995554
26Hypergammaglobulinemia (HP:0010702)3.50022282
27Gingivitis (HP:0000230)3.39834952
28Recurrent cutaneous fungal infections (HP:0011370)3.34707271
29Chronic mucocutaneous candidiasis (HP:0002728)3.34707271
30Recurrent bronchitis (HP:0002837)3.27341122
31Nuclear cataract (HP:0100018)3.18906588
32Tetraparesis (HP:0002273)3.18607718
33Increased cerebral lipofuscin (HP:0011813)3.15860935
34Obstructive lung disease (HP:0006536)3.07970299
35Chronic obstructive pulmonary disease (HP:0006510)3.07970299
36Pulmonary infiltrates (HP:0002113)3.00577210
37Vacuolated lymphocytes (HP:0001922)2.97764044
38Autoimmune hemolytic anemia (HP:0001890)2.96150183
39Gangrene (HP:0100758)2.95767284
40Urticaria (HP:0001025)2.91750574
41Pustule (HP:0200039)2.88493329
42Porencephaly (HP:0002132)2.86598658
43Parakeratosis (HP:0001036)2.84279422
44Increased neuronal autofluorescent lipopigment (HP:0002074)2.83782309
45Chronic sinusitis (HP:0011109)2.80927192
46Mutism (HP:0002300)2.69649473
47Encephalitis (HP:0002383)2.66313013
48Cellulitis (HP:0100658)2.64708389
49Gingival bleeding (HP:0000225)2.64523273
50Progressive neurologic deterioration (HP:0002344)2.63270301
51Thick nail (HP:0001805)2.61425085
52Leukocytosis (HP:0001974)2.61227955
53Axonal loss (HP:0003447)2.58454235
54T lymphocytopenia (HP:0005403)2.56991537
55Periodontitis (HP:0000704)2.56107356
56Hemoptysis (HP:0002105)2.55487863
57Peritonitis (HP:0002586)2.55359572
58Prostate neoplasm (HP:0100787)2.54849934
59Myocardial infarction (HP:0001658)2.53671945
60Vertebral compression fractures (HP:0002953)2.51433634
61Petechiae (HP:0000967)2.50903367
62Gastrointestinal infarctions (HP:0005244)2.49720385
63Gastrointestinal stroma tumor (HP:0100723)2.49615709
64Abnormality of mucopolysaccharide metabolism (HP:0011020)2.49251342
65Abnormality of polysaccharide metabolism (HP:0011012)2.49251342
66Abnormality of glycosaminoglycan metabolism (HP:0004371)2.49251342
67IgA deficiency (HP:0002720)2.49222156
68Increased IgE level (HP:0003212)2.47342508
69Arterial thrombosis (HP:0004420)2.44989715
70Abnormality of the pleura (HP:0002103)2.42527842
71Joint swelling (HP:0001386)2.41627759
72Keratoconjunctivitis sicca (HP:0001097)2.40369785
73Loss of speech (HP:0002371)2.36929661
74Anorexia (HP:0002039)2.36488672
75Meningitis (HP:0001287)2.35632035
76Neurofibrillary tangles (HP:0002185)2.35421838
77Emphysema (HP:0002097)2.34635677
78Polyneuropathy (HP:0001271)2.31315134
79Purpura (HP:0000979)2.30643597
80Eosinophilia (HP:0001880)2.27998476
81Prolonged neonatal jaundice (HP:0006579)2.27021996
82Apathy (HP:0000741)2.26545119
83Abnormality of B cell number (HP:0010975)2.25816359
84Nephritis (HP:0000123)2.25512665
85Osteomyelitis (HP:0002754)2.23436619
86Keratoconjunctivitis (HP:0001096)2.23183902
87Abnormality of T cell number (HP:0011839)2.21592063
88Hematochezia (HP:0002573)2.20966772
89Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.20734136
90Skin ulcer (HP:0200042)2.18304217
91Glomerulonephritis (HP:0000099)2.17783215
92Recurrent lower respiratory tract infections (HP:0002783)2.15777516
93Recurrent pneumonia (HP:0006532)2.15042572
94Osteolytic defects of the phalanges of the hand (HP:0009771)2.14879251
95Osteolytic defects of the hand bones (HP:0009699)2.14879251
96Diminished motivation (HP:0000745)2.14048321
97Dysostosis multiplex (HP:0000943)2.13250297
98Abnormality of glycolipid metabolism (HP:0010969)2.12093543
99Abnormality of liposaccharide metabolism (HP:0010968)2.12093543
100Abnormality of glycosphingolipid metabolism (HP:0004343)2.12093543
101Premature loss of primary teeth (HP:0006323)2.12066670
102Abnormality of the pericardium (HP:0001697)2.11796895
103Abnormality of T cell physiology (HP:0011840)2.08219988
104B lymphocytopenia (HP:0010976)2.07876057
105Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.06801720
106Colitis (HP:0002583)2.06020102
107Increased serum ferritin (HP:0003281)2.05786589
108Abnormality of T cells (HP:0002843)2.05353481
109Joint hemorrhage (HP:0005261)2.05164910
110Upper motor neuron abnormality (HP:0002127)2.04630871
111Hepatosplenomegaly (HP:0001433)2.04238551
112Bone pain (HP:0002653)2.04038598
113Arthralgia (HP:0002829)2.03087554
114Abnormality of the basal ganglia (HP:0002134)2.02644081
115Glomerulopathy (HP:0100820)2.02446971
116Abnormality of iron homeostasis (HP:0011031)2.00997350
117Spontaneous hematomas (HP:0007420)2.00837822
118Memory impairment (HP:0002354)2.00119421
119Nausea (HP:0002018)1.99413116
120Lymphopenia (HP:0001888)1.98630851
121Poor head control (HP:0002421)1.98372132
122Cheilitis (HP:0100825)1.97235032
123Acne (HP:0001061)1.96733308
124Pulmonary embolism (HP:0002204)1.96242516
125Malnutrition (HP:0004395)1.95529881
126Complement deficiency (HP:0004431)1.95113461
127Abnormal delayed hypersensitivity skin test (HP:0002963)1.95082908
128Abnormality of eosinophils (HP:0001879)1.94347060
129Abnormality of cells of the lymphoid lineage (HP:0012140)1.93589463
130Urinary glycosaminoglycan excretion (HP:0003541)1.93068401
131Mucopolysacchariduria (HP:0008155)1.93068401
132Amyloidosis (HP:0011034)1.92508204
133Esophageal varix (HP:0002040)1.91825675

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TBK14.86246187
2IKBKE4.27392198
3TYK24.23030561
4MAP3K144.07775491
5BLK3.24858734
6GRK73.04472187
7JAK33.02102956
8PBK2.98421831
9TAOK22.92244646
10KIT2.87105802
11FGFR42.86067631
12ERN12.83607079
13JAK12.64625960
14IRAK32.45285101
15IRAK42.44023082
16IKBKB2.42537207
17MAP4K12.23490745
18TXK2.23028727
19RIPK42.22178452
20PIM22.08106915
21PRPF4B2.00604276
22TAOK11.79057859
23EPHB11.78954370
24MAP3K131.69012532
25CSK1.64783054
26EPHA31.60107023
27FGFR31.56113316
28MAP2K31.53314776
29CHUK1.49524421
30ZAP701.47630356
31NME21.43266966
32MST41.41016371
33BMX1.29771229
34SYK1.22172228
35RPS6KA41.18441550
36HCK1.16384098
37FGR1.16010600
38JAK21.10962300
39LCK1.05130437
40ADRBK21.03034685
41ABL21.02756928
42MATK0.93977157
43CDC42BPA0.92539491
44LYN0.91176777
45PIM10.90504789
46BTK0.89345828
47NEK90.87580091
48CSF1R0.86553925
49EIF2AK20.81796340
50FES0.80551484
51IRAK10.80050921
52HIPK20.79445333
53MST1R0.75555154
54TAOK30.74030818
55TGFBR20.73189859
56STK100.73184142
57MAP3K50.72871979
58STK40.72855464
59MAP3K100.72480678
60MARK30.71878598
61TESK10.68894942
62KDR0.67385345
63TEC0.66205166
64MAP2K60.63302279
65PTK60.62356790
66ARAF0.61201697
67EGFR0.60381045
68PRKCD0.59610666
69LRRK20.57701260
70ABL10.57658291
71SIK30.55555218
72TNK20.55411862
73BMPR20.51516261
74DAPK30.51159803
75NLK0.50390075
76RIPK10.50030113
77RPS6KA50.48781126
78TRIB30.48420125
79MAP3K10.47743558
80DYRK30.46741346
81CLK10.46109837
82LATS20.44712194
83GRK60.43342303
84MAPK110.41970995
85SIK10.41853879
86PAK40.41801480
87SMG10.41345396
88TTN0.41333052
89PRKG20.41271068
90MOS0.41111813
91PRKCQ0.37377195
92MAPKAPK20.36801708
93STK30.35854180
94MAP3K110.34844064
95ITK0.34338618
96EPHA20.33862981
97PKN10.32598605
98TRPM70.32446486
99ERBB40.31531847
100TESK20.31254720
101BRAF0.30046877
102ALK0.29445738
103PDK10.29230107
104TYRO30.28155786
105MAPK70.27636153
106DDR20.25837360
107INSR0.25492192
108FYN0.24627905
109SRC0.21815848
110ICK0.20941967
111RPS6KL10.19647029
112RPS6KC10.19647029
113SIK20.19644705
114RPS6KA10.18288033
115PAK10.18178249
116DYRK1B0.18011668
117MAPK40.17902877
118PRKCH0.16789739
119IGF1R0.16159083
120MAP3K30.15631572
121IRAK20.14630968
122PDPK10.11502865
123MAPK30.10888126
124TLK10.10811803
125CDK60.10625484

Predicted pathways (KEGG)

RankGene SetZ-score
1Leishmaniasis_Homo sapiens_hsa051403.34687484
2Toll-like receptor signaling pathway_Homo sapiens_hsa046203.18584063
3Cytosolic DNA-sensing pathway_Homo sapiens_hsa046233.14748636
4Graft-versus-host disease_Homo sapiens_hsa053323.08367311
5Allograft rejection_Homo sapiens_hsa053302.84651940
6NF-kappa B signaling pathway_Homo sapiens_hsa040642.78518031
7Measles_Homo sapiens_hsa051622.65349600
8Staphylococcus aureus infection_Homo sapiens_hsa051502.64518745
9* RIG-I-like receptor signaling pathway_Homo sapiens_hsa046222.61832273
10Malaria_Homo sapiens_hsa051442.42201161
11Legionellosis_Homo sapiens_hsa051342.31279008
12Influenza A_Homo sapiens_hsa051642.27635260
13Pertussis_Homo sapiens_hsa051332.25839664
14Osteoclast differentiation_Homo sapiens_hsa043802.21718319
15Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.17639451
16Intestinal immune network for IgA production_Homo sapiens_hsa046722.12130457
17NOD-like receptor signaling pathway_Homo sapiens_hsa046212.09894274
18TNF signaling pathway_Homo sapiens_hsa046682.06775793
19Herpes simplex infection_Homo sapiens_hsa051682.03359762
20Tuberculosis_Homo sapiens_hsa051521.94812531
21Rheumatoid arthritis_Homo sapiens_hsa053231.90449133
22Antigen processing and presentation_Homo sapiens_hsa046121.81256129
23Type I diabetes mellitus_Homo sapiens_hsa049401.76068709
24Asthma_Homo sapiens_hsa053101.75652910
25African trypanosomiasis_Homo sapiens_hsa051431.73948657
26Toxoplasmosis_Homo sapiens_hsa051451.72063073
27Primary immunodeficiency_Homo sapiens_hsa053401.66424993
28Salmonella infection_Homo sapiens_hsa051321.60838810
29Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.53249950
30Hepatitis C_Homo sapiens_hsa051601.52608642
31Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.49014990
32Jak-STAT signaling pathway_Homo sapiens_hsa046301.45194676
33Hematopoietic cell lineage_Homo sapiens_hsa046401.40424925
34Autoimmune thyroid disease_Homo sapiens_hsa053201.39313977
35Chemokine signaling pathway_Homo sapiens_hsa040621.34931671
36Apoptosis_Homo sapiens_hsa042101.34508991
37B cell receptor signaling pathway_Homo sapiens_hsa046621.30928345
38Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.29318819
39Hepatitis B_Homo sapiens_hsa051611.28743583
40Lysosome_Homo sapiens_hsa041421.23879294
41Shigellosis_Homo sapiens_hsa051311.21992309
42Viral myocarditis_Homo sapiens_hsa054161.18135635
43Phagosome_Homo sapiens_hsa041451.16095891
44Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.00304789
45Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.00095942
46Caffeine metabolism_Homo sapiens_hsa002320.96245970
47AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.94072229
48Amoebiasis_Homo sapiens_hsa051460.90209709
49T cell receptor signaling pathway_Homo sapiens_hsa046600.88689245
50Other glycan degradation_Homo sapiens_hsa005110.82132409
51Complement and coagulation cascades_Homo sapiens_hsa046100.82062683
52Prolactin signaling pathway_Homo sapiens_hsa049170.80575670
53Glycosaminoglycan degradation_Homo sapiens_hsa005310.79167609
54Bladder cancer_Homo sapiens_hsa052190.77140532
55Leukocyte transendothelial migration_Homo sapiens_hsa046700.72991000
56Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.71941978
57Adipocytokine signaling pathway_Homo sapiens_hsa049200.71307451
58Acute myeloid leukemia_Homo sapiens_hsa052210.69350314
59Prion diseases_Homo sapiens_hsa050200.68527425
60Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.66380739
61Sulfur metabolism_Homo sapiens_hsa009200.66343550
62Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.65445103
63Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.61503621
64Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.61193658
65Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.60899838
66Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.59637454
67Viral carcinogenesis_Homo sapiens_hsa052030.57554703
68Small cell lung cancer_Homo sapiens_hsa052220.53880368
69Mineral absorption_Homo sapiens_hsa049780.52802543
70Chronic myeloid leukemia_Homo sapiens_hsa052200.52405082
71Epstein-Barr virus infection_Homo sapiens_hsa051690.50751450
72Pancreatic cancer_Homo sapiens_hsa052120.50323326
73Sphingolipid metabolism_Homo sapiens_hsa006000.49412900
74HIF-1 signaling pathway_Homo sapiens_hsa040660.47456090
75Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.43473703
76Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.41403760
77Arginine biosynthesis_Homo sapiens_hsa002200.40792440
78Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.39682813
79Galactose metabolism_Homo sapiens_hsa000520.37021844
80Proteasome_Homo sapiens_hsa030500.37007633
81SNARE interactions in vesicular transport_Homo sapiens_hsa041300.35951494
82Systemic lupus erythematosus_Homo sapiens_hsa053220.35539205
83Fructose and mannose metabolism_Homo sapiens_hsa000510.32301289
84Folate biosynthesis_Homo sapiens_hsa007900.31609758
85Platelet activation_Homo sapiens_hsa046110.31604798
86Neurotrophin signaling pathway_Homo sapiens_hsa047220.30963599
87Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.30700158
88VEGF signaling pathway_Homo sapiens_hsa043700.28532912
89Transcriptional misregulation in cancer_Homo sapiens_hsa052020.27830626
90Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.27710112
91HTLV-I infection_Homo sapiens_hsa051660.26922294
92Type II diabetes mellitus_Homo sapiens_hsa049300.26259582
93Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.26018012
94Pentose and glucuronate interconversions_Homo sapiens_hsa000400.25118314
95Collecting duct acid secretion_Homo sapiens_hsa049660.25048811
96Notch signaling pathway_Homo sapiens_hsa043300.24840243
97Primary bile acid biosynthesis_Homo sapiens_hsa001200.22182189
98Vibrio cholerae infection_Homo sapiens_hsa051100.20160908
99ABC transporters_Homo sapiens_hsa020100.20073825
100Proteoglycans in cancer_Homo sapiens_hsa052050.19651704
101Insulin resistance_Homo sapiens_hsa049310.18992819
102Sphingolipid signaling pathway_Homo sapiens_hsa040710.18588692
103Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.16905978
104Sulfur relay system_Homo sapiens_hsa041220.14862371
105Regulation of actin cytoskeleton_Homo sapiens_hsa048100.14601919
106Tryptophan metabolism_Homo sapiens_hsa003800.12435930
107Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.12376191
108p53 signaling pathway_Homo sapiens_hsa041150.11196673
109Endocytosis_Homo sapiens_hsa041440.10776466
110Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.08748943
111Histidine metabolism_Homo sapiens_hsa003400.07906345
112MAPK signaling pathway_Homo sapiens_hsa040100.06990702
113MicroRNAs in cancer_Homo sapiens_hsa052060.06579961
114FoxO signaling pathway_Homo sapiens_hsa040680.05371159

Most similar genes based on co-expression Upload to Enrichr

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