ISG20

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1antigen processing and presentation of endogenous peptide antigen (GO:0002483)7.53851306
2antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)7.53851306
3antigen processing and presentation of endogenous antigen (GO:0019883)6.87614349
4antigen processing and presentation via MHC class Ib (GO:0002475)5.22859991
5signal peptide processing (GO:0006465)5.03794418
6* response to type I interferon (GO:0034340)4.90534243
7antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.89237126
8* cellular response to type I interferon (GO:0071357)4.85806726
9* type I interferon signaling pathway (GO:0060337)4.85806726
10protoporphyrinogen IX metabolic process (GO:0046501)4.80761029
11negative regulation of cell killing (GO:0031342)4.67001772
12negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.67001772
13doxorubicin metabolic process (GO:0044598)4.56304515
14daunorubicin metabolic process (GO:0044597)4.56304515
15polyketide metabolic process (GO:0030638)4.56304515
16protoporphyrinogen IX biosynthetic process (GO:0006782)4.46661068
17heme biosynthetic process (GO:0006783)4.29332656
18negative regulation of interleukin-12 production (GO:0032695)4.18295085
19response to interferon-beta (GO:0035456)4.17537665
20response to interferon-alpha (GO:0035455)4.03451938
21regulation of antigen processing and presentation of peptide antigen (GO:0002583)4.02001132
22positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.96157765
23positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.90420739
24regulation of dendritic cell antigen processing and presentation (GO:0002604)3.88957073
25regulation of T cell tolerance induction (GO:0002664)3.78270984
26regulation of B cell receptor signaling pathway (GO:0050855)3.77423761
27porphyrin-containing compound biosynthetic process (GO:0006779)3.75010371
28immunoglobulin mediated immune response (GO:0016064)3.74840027
29macrophage activation involved in immune response (GO:0002281)3.74716990
30modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.69631062
31positive regulation by organism of defense response of other organism involved in symbiotic interact3.69631062
32modulation by symbiont of host immune response (GO:0052553)3.69631062
33positive regulation by symbiont of host defense response (GO:0052509)3.69631062
34modulation by symbiont of host defense response (GO:0052031)3.69631062
35modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.69631062
36cellular response to interferon-beta (GO:0035458)3.65680957
37detection of other organism (GO:0098543)3.62361649
38erythrocyte maturation (GO:0043249)3.61993041
39detection of bacterium (GO:0016045)3.61962698
40* negative regulation of viral genome replication (GO:0045071)3.60549503
41positive regulation of type 2 immune response (GO:0002830)3.60376100
42Golgi transport vesicle coating (GO:0048200)3.57701363
43COPI coating of Golgi vesicle (GO:0048205)3.57701363
44negative regulation of T cell mediated immunity (GO:0002710)3.54466494
45positive regulation of interferon-alpha production (GO:0032727)3.53113663
46heme metabolic process (GO:0042168)3.53032740
47regulation of regulatory T cell differentiation (GO:0045589)3.51812307
48regulation of chronic inflammatory response (GO:0002676)3.51511389
49myeloid dendritic cell differentiation (GO:0043011)3.50757531
50regulation of interferon-beta biosynthetic process (GO:0045357)3.50654539
51negative T cell selection (GO:0043383)3.43452412
52regulation of RIG-I signaling pathway (GO:0039535)3.42791767
53interferon-gamma-mediated signaling pathway (GO:0060333)3.38209713
54positive regulation of gamma-delta T cell activation (GO:0046645)3.37643540
55negative thymic T cell selection (GO:0045060)3.37138916
56regulation of interferon-alpha production (GO:0032647)3.35420946
57cellular response to virus (GO:0098586)3.33209107
58leukocyte aggregation (GO:0070486)3.28682534
59tetrapyrrole biosynthetic process (GO:0033014)3.27763630
60regulation of tolerance induction (GO:0002643)3.25583305
61negative regulation of cytokine production involved in immune response (GO:0002719)3.25167789
62myeloid dendritic cell activation (GO:0001773)3.22806184
63regulation of alpha-beta T cell proliferation (GO:0046640)3.22561930
64germinal center formation (GO:0002467)3.22241017
65ribosomal small subunit assembly (GO:0000028)3.22147984
66cellular response to interleukin-15 (GO:0071350)3.21811309
67response to interleukin-15 (GO:0070672)3.20083533
68regulation of response to osmotic stress (GO:0047484)3.12934806
69regulation of T cell mediated cytotoxicity (GO:0001914)3.12541743
70lipopolysaccharide-mediated signaling pathway (GO:0031663)3.10857342
71porphyrin-containing compound metabolic process (GO:0006778)3.10437306
72negative regulation of lymphocyte mediated immunity (GO:0002707)3.10322746
73positive thymic T cell selection (GO:0045059)3.08477967
74positive regulation of tolerance induction (GO:0002645)3.07825781
75lymphocyte chemotaxis (GO:0048247)3.06110799
76regulation of natural killer cell mediated immunity (GO:0002715)3.05533604
77regulation of natural killer cell mediated cytotoxicity (GO:0042269)3.05533604
78T-helper 1 type immune response (GO:0042088)3.04731225
79regulation of interleukin-12 production (GO:0032655)3.04576198
80regulation of type 2 immune response (GO:0002828)3.02880808
81regulation of vitamin D biosynthetic process (GO:0060556)3.02240421
82positive regulation of T cell mediated cytotoxicity (GO:0001916)2.99587386
83regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043370)2.98964022
84regulation of type I interferon-mediated signaling pathway (GO:0060338)2.98304308
85erythrocyte development (GO:0048821)2.97751207
86defense response to protozoan (GO:0042832)2.96585831
87regulation of erythrocyte differentiation (GO:0045646)2.95560800
88SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.95075149
89regulation of interleukin-2 biosynthetic process (GO:0045076)2.93694428
90positive regulation of humoral immune response (GO:0002922)2.93633198
91myeloid cell activation involved in immune response (GO:0002275)2.92535039
92B cell receptor signaling pathway (GO:0050853)2.92137688
93positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)2.91509634
94positive regulation of erythrocyte differentiation (GO:0045648)2.90469978
95regulation of CD4-positive, alpha-beta T cell activation (GO:2000514)2.90213518
96granulocyte activation (GO:0036230)2.89643059
97positive regulation of interleukin-17 production (GO:0032740)2.89593059
98response to peptidoglycan (GO:0032494)2.89094378
99positive regulation of B cell mediated immunity (GO:0002714)2.88933124
100positive regulation of immunoglobulin mediated immune response (GO:0002891)2.88933124
101detection of external biotic stimulus (GO:0098581)2.88931990
102positive regulation of defense response to virus by host (GO:0002230)2.88305854
103cellular response to exogenous dsRNA (GO:0071360)2.88137241
104regulation of leukocyte mediated cytotoxicity (GO:0001910)2.86513438
105protein targeting to ER (GO:0045047)2.85924070
106positive regulation of alpha-beta T cell proliferation (GO:0046641)2.85864162
107B cell mediated immunity (GO:0019724)2.84711671
108positive regulation of natural killer cell differentiation (GO:0032825)2.84494988
109cotranslational protein targeting to membrane (GO:0006613)2.83055252
110negative regulation of leukocyte mediated immunity (GO:0002704)2.82420722
111production of molecular mediator involved in inflammatory response (GO:0002532)2.82392395
112T cell selection (GO:0045058)2.82374815
113chaperone mediated protein folding requiring cofactor (GO:0051085)2.82181393
114NIK/NF-kappaB signaling (GO:0038061)2.81905314
115positive regulation of antigen processing and presentation (GO:0002579)2.80241722
116negative regulation of viral entry into host cell (GO:0046597)2.80217818
117response to protozoan (GO:0001562)2.74417715
118establishment of protein localization to endoplasmic reticulum (GO:0072599)2.71496632
119regulation of antigen processing and presentation (GO:0002577)2.71303084
120protein localization to endoplasmic reticulum (GO:0070972)2.69780505
121aminoglycoside antibiotic metabolic process (GO:0030647)2.68586366
122hemoglobin metabolic process (GO:0020027)2.68115336
123negative regulation of erythrocyte differentiation (GO:0045647)2.64256410
124mature B cell differentiation involved in immune response (GO:0002313)2.64234466
125regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway (GO:0039531)2.62979104
126negative regulation of type I interferon production (GO:0032480)2.61700046
127* defense response to virus (GO:0051607)2.61130072
128sequestering of metal ion (GO:0051238)2.61011256
129GDP-mannose metabolic process (GO:0019673)2.58626528
130regulation of interleukin-12 biosynthetic process (GO:0045075)2.58333873
131positive regulation of interferon-beta production (GO:0032728)2.58108425
132JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.57491990
133antimicrobial humoral response (GO:0019730)2.55793780
134neutrophil activation involved in immune response (GO:0002283)2.55667010
135maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.55095169
136positive regulation of interferon-gamma biosynthetic process (GO:0045078)2.54081721
137mature B cell differentiation (GO:0002335)2.52148586
138regulation of T-helper 1 cell differentiation (GO:0045625)2.51539763
139positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.51448271
140positive regulation of isotype switching (GO:0045830)2.49966859
141interferon-gamma production (GO:0032609)2.49460630
142regulation of gamma-delta T cell differentiation (GO:0045586)2.49174680
143* regulation of viral genome replication (GO:0045069)2.46870251
144* negative regulation of viral process (GO:0048525)2.45874866
145response to interferon-gamma (GO:0034341)2.45709086
146cellular response to interferon-gamma (GO:0071346)2.43435553
147DNA deamination (GO:0045006)2.42957114
148T cell migration (GO:0072678)2.39612290
149natural killer cell activation (GO:0030101)2.39526820
150regulation of gamma-delta T cell activation (GO:0046643)2.38515871
151regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.37831698
152protein maturation by protein folding (GO:0022417)2.36496586
153definitive hemopoiesis (GO:0060216)2.34220798
154cellular response to interferon-alpha (GO:0035457)2.33216907
155CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)2.33032619
156regulation of defense response to virus by host (GO:0050691)2.32364005
157iron-sulfur cluster assembly (GO:0016226)2.31514041
158metallo-sulfur cluster assembly (GO:0031163)2.31514041
159protein retention in ER lumen (GO:0006621)2.31094486
160erythrocyte differentiation (GO:0030218)2.30597767
161innate immune response in mucosa (GO:0002227)2.30449976

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human5.78509931
2GATA1_22025678_ChIP-Seq_K562_Human4.27172674
3* IRF8_22096565_ChIP-ChIP_GC-B_Mouse4.26697078
4IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.70355720
5* IRF8_21731497_ChIP-ChIP_J774_Mouse3.33263321
6SCL_19346495_ChIP-Seq_HPC-7_Human2.96839993
7MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.78744541
8EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.76875863
9E2F7_22180533_ChIP-Seq_HELA_Human2.65453970
10FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.65000101
11* SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.61549043
12STAT4_19710469_ChIP-ChIP_TH1__Mouse2.55755023
13BP1_19119308_ChIP-ChIP_Hs578T_Human2.47209705
14SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.40689596
15SMAD_19615063_ChIP-ChIP_OVARY_Human2.32800202
16NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.29973440
17STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.21767917
18RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.13453052
19* IRF8_27001747_Chip-Seq_BMDM_Mouse2.10990445
20MYB_21317192_ChIP-Seq_ERMYB_Mouse2.06048406
21* TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse2.03737663
22* FLI1_20887958_ChIP-Seq_HPC-7_Mouse2.00293370
23NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.96103298
24SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.93193415
25TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.89657877
26MYC_22102868_ChIP-Seq_BL_Human1.88194361
27GATA1_22383799_ChIP-Seq_G1ME_Mouse1.85664706
28* MYB_26560356_Chip-Seq_TH2_Human1.84522360
29FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.82994747
30* SPI1_23547873_ChIP-Seq_NB4_Human1.82737130
31ELF1_17652178_ChIP-ChIP_JURKAT_Human1.75281430
32ERG_20887958_ChIP-Seq_HPC-7_Mouse1.74771850
33STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.73651299
34MAF_26560356_Chip-Seq_TH1_Human1.72775494
35EGR1_19374776_ChIP-ChIP_THP-1_Human1.68364201
36LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.66560587
37GATA1_19941827_ChIP-Seq_MEL_Mouse1.65015118
38* RUNX1_22412390_ChIP-Seq_EML_Mouse1.64533386
39RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.61881305
40GATA2_22383799_ChIP-Seq_G1ME_Mouse1.61544428
41* MYB_26560356_Chip-Seq_TH1_Human1.61028790
42* STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.60606178
43LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.59506532
44MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.57353289
45GATA1_19941826_ChIP-Seq_K562_Human1.56131447
46Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.56049919
47NOTCH1_21737748_ChIP-Seq_TLL_Human1.55794855
48VDR_24787735_ChIP-Seq_THP-1_Human1.54670369
49ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.53914365
50VDR_21846776_ChIP-Seq_THP-1_Human1.48784948
51SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.48514639
52VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.45031405
53* BRD4_27068464_Chip-Seq_AML-cells_Mouse1.43389989
54HOXB4_20404135_ChIP-ChIP_EML_Mouse1.42475262
55VDR_24763502_ChIP-Seq_THP-1_Human1.40803172
56* VDR_23849224_ChIP-Seq_CD4+_Human1.40660882
57TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.37229253
58GABP_17652178_ChIP-ChIP_JURKAT_Human1.34563683
59GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.31039101
60UTX_26944678_Chip-Seq_JUKART_Human1.30982794
61PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.29288189
62* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.28555906
63* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.27548614
64SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.26692346
65NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.25322373
66STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.25027279
67TCF7_22412390_ChIP-Seq_EML_Mouse1.21003229
68VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.20236019
69EGR1_23403033_ChIP-Seq_LIVER_Mouse1.19632354
70CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.18421706
71SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.18192963
72GATA3_27048872_Chip-Seq_THYMUS_Human1.17466843
73KDM2B_26808549_Chip-Seq_SUP-B15_Human1.16701594
74NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.16016891
75GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.14878185
76NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.13511456
77FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.12250172
78CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.11004818
79SPI1_23127762_ChIP-Seq_K562_Human1.10267713
80MAF_26560356_Chip-Seq_TH2_Human1.09689623
81PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.07763886
82KDM2B_26808549_Chip-Seq_DND41_Human1.07256442
83PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.07044824
84CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.06483257
85GATA2_21666600_ChIP-Seq_HMVEC_Human1.05669861
86STAT6_21828071_ChIP-Seq_BEAS2B_Human1.05125697
87EST1_17652178_ChIP-ChIP_JURKAT_Human1.04889245
88PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.04190175
89NCOR1_26117541_ChIP-Seq_K562_Human1.02901251
90CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.02371881
91HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.02216254
92MYC_18555785_ChIP-Seq_MESCs_Mouse1.02153747
93* BCL6_27268052_Chip-Seq_Bcells_Human1.01843220
94TFEB_21752829_ChIP-Seq_HELA_Human1.01603294
95RUNX_20019798_ChIP-Seq_JUKART_Human1.00948192
96PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.00265270
97PU.1_20513432_ChIP-Seq_Bcells_Mouse1.00079683
98KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.99293642
99CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.99057581
100STAT3_1855785_ChIP-Seq_MESCs_Mouse0.98975992
101HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.98778280
102* CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.98040448
103JARID1A_20064375_ChIP-Seq_MESCs_Mouse0.97914240
104KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse0.96455834
105GATA2_19941826_ChIP-Seq_K562_Human0.96161225
106FOXP3_21729870_ChIP-Seq_TREG_Human0.95753458
107KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.95175851
108ETS1_22383799_ChIP-Seq_G1ME_Mouse0.95140894
109GATA3_26560356_Chip-Seq_TH2_Human0.94776618
110SRF_21415370_ChIP-Seq_HL-1_Mouse0.93921949
111CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.93164022
112ELK3_25401928_ChIP-Seq_HUVEC_Human0.93106952
113ELF1_20517297_ChIP-Seq_JURKAT_Human0.92522798
114ELK1_19687146_ChIP-ChIP_HELA_Human0.92416677
115E2F4_17652178_ChIP-ChIP_JURKAT_Human0.91315261
116BCOR_27268052_Chip-Seq_Bcells_Human0.91275302
117STAT1_20625510_ChIP-Seq_HELA_Human0.90143682
118PU_27001747_Chip-Seq_BMDM_Mouse0.88334468
119FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.87760739
120EGR1_19032775_ChIP-ChIP_M12_Human0.87331615
121KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human0.85901120
122CTCF_26484167_Chip-Seq_Bcells_Mouse0.85520250
123MYC_18358816_ChIP-ChIP_MESCs_Mouse0.84949124
124* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.79269067
125GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.76926836
126SMRT_27268052_Chip-Seq_Bcells_Human0.74309657
127* LXR_22292898_ChIP-Seq_THP-1_Human0.74266899
128RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.72890275
129P300_27268052_Chip-Seq_Bcells_Human0.70455250
130RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.67865881
131GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.67587225

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation3.93486186
2MP0003656_abnormal_erythrocyte_physiolo3.58505887
3MP0005671_abnormal_response_to3.34854380
4MP0000685_abnormal_immune_system3.27429954
5MP0009785_altered_susceptibility_to3.02551411
6MP0005387_immune_system_phenotype2.80635144
7MP0001790_abnormal_immune_system2.80635144
8MP0003724_increased_susceptibility_to2.72307998
9MP0004147_increased_porphyrin_level2.62380789
10MP0003436_decreased_susceptibility_to2.58721664
11MP0005000_abnormal_immune_tolerance2.48988655
12MP0005025_abnormal_response_to2.46338944
13MP0002877_abnormal_melanocyte_morpholog2.37744548
14MP0002148_abnormal_hypersensitivity_rea2.31579364
15MP0001800_abnormal_humoral_immune2.29561584
16MP0002166_altered_tumor_susceptibility2.16057151
17MP0002723_abnormal_immune_serum2.14591175
18MP0002452_abnormal_antigen_presenting2.06554942
19MP0003183_abnormal_peptide_metabolism2.02312751
20MP0006082_CNS_inflammation2.02251259
21MP0002398_abnormal_bone_marrow1.99899218
22MP0001819_abnormal_immune_cell1.96766205
23MP0002420_abnormal_adaptive_immunity1.95762160
24MP0005397_hematopoietic_system_phenotyp1.91748266
25MP0001545_abnormal_hematopoietic_system1.91748266
26MP0002419_abnormal_innate_immunity1.81555236
27MP0009333_abnormal_splenocyte_physiolog1.80089454
28MP0002693_abnormal_pancreas_physiology1.78883751
29MP0004947_skin_inflammation1.78611198
30MP0002405_respiratory_system_inflammati1.75743728
31MP0003763_abnormal_thymus_physiology1.75035895
32MP0000716_abnormal_immune_system1.72516054
33MP0004264_abnormal_extraembryonic_tissu1.72182218
34MP0002006_tumorigenesis1.69625182
35MP0006054_spinal_hemorrhage1.65393735
36MP0003300_gastrointestinal_ulcer1.62777898
37MP0002429_abnormal_blood_cell1.62730330
38MP0005464_abnormal_platelet_physiology1.61976629
39MP0001845_abnormal_inflammatory_respons1.60472508
40MP0000689_abnormal_spleen_morphology1.60280808
41MP0005310_abnormal_salivary_gland1.59638579
42MP0002396_abnormal_hematopoietic_system1.58359784
43MP0002722_abnormal_immune_system1.58017235
44MP0010155_abnormal_intestine_physiology1.57528508
45MP0005451_abnormal_body_composition1.54259048
46MP0000490_abnormal_crypts_of1.53781528
47MP0008469_abnormal_protein_level1.51435267
48MP0004808_abnormal_hematopoietic_stem1.49313833
49MP0001533_abnormal_skeleton_physiology1.46801080
50MP0002138_abnormal_hepatobiliary_system1.43377315
51MP0002132_abnormal_respiratory_system1.35791912
52MP0001853_heart_inflammation1.32390011
53MP0003186_abnormal_redox_activity1.31011647
54MP0004510_myositis1.31011496
55MP0003303_peritoneal_inflammation1.29073225
56MP0009764_decreased_sensitivity_to1.28916473
57MP0003075_altered_response_to1.25426895
58MP0003866_abnormal_defecation1.19475249
59MP0001944_abnormal_pancreas_morphology1.17912661
60MP0009840_abnormal_foam_cell1.15574291
61MP0000858_altered_metastatic_potential1.14438738
62MP0005636_abnormal_mineral_homeostasis1.13621381
63MP0000703_abnormal_thymus_morphology1.13178565
64MP0002933_joint_inflammation1.12899933
65MP0005075_abnormal_melanosome_morpholog1.12541191
66MP0004043_abnormal_pH_regulation1.11818881
67MP0005166_decreased_susceptibility_to1.11206918
68MP0008004_abnormal_stomach_pH1.10236065
69MP0005379_endocrine/exocrine_gland_phen1.09683437
70MP0002332_abnormal_exercise_endurance1.07246580
71MP0003806_abnormal_nucleotide_metabolis1.05236028
72MP0005058_abnormal_lysosome_morphology1.04934911
73MP0000465_gastrointestinal_hemorrhage1.03252878
74MP0000343_altered_response_to1.02562784
75MP0001986_abnormal_taste_sensitivity1.01113921
76MP0001348_abnormal_lacrimal_gland0.98307557
77MP0003172_abnormal_lysosome_physiology0.95953623
78MP0002139_abnormal_hepatobiliary_system0.95462955
79MP0005083_abnormal_biliary_tract0.94823572
80MP0001663_abnormal_digestive_system0.94023329
81MP0001873_stomach_inflammation0.93532474
82MP0004782_abnormal_surfactant_physiolog0.91683833
83MP0003448_altered_tumor_morphology0.91211048
84MP0010352_gastrointestinal_tract_polyps0.90858331
85MP0002928_abnormal_bile_duct0.89103104
86MP0008260_abnormal_autophagy0.88479097
87MP0000678_abnormal_parathyroid_gland0.88323707
88MP0003045_fibrosis0.88049489
89MP0009643_abnormal_urine_homeostasis0.87363174
90MP0002019_abnormal_tumor_incidence0.86659815
91MP0004883_abnormal_blood_vessel0.86274095
92MP0005220_abnormal_exocrine_pancreas0.85988324
93MP0000604_amyloidosis0.85968986
94MP0001851_eye_inflammation0.84738972
95MP0002998_abnormal_bone_remodeling0.84734573
96MP0005164_abnormal_response_to0.83225516
97MP0009763_increased_sensitivity_to0.83090687
98MP0001881_abnormal_mammary_gland0.81701781
99MP0002277_abnormal_respiratory_mucosa0.80389545
100MP0003795_abnormal_bone_structure0.80280450
101MP0002909_abnormal_adrenal_gland0.80110620
102MP0009278_abnormal_bone_marrow0.77670199
103MP0005390_skeleton_phenotype0.77250140
104MP0003693_abnormal_embryo_hatching0.76659770
105MP0002163_abnormal_gland_morphology0.74841245
106MP0003195_calcinosis0.74322225
107MP0003191_abnormal_cellular_cholesterol0.74293611
108MP0000313_abnormal_cell_death0.73443780
109MP0002254_reproductive_system_inflammat0.73171669
110MP0004381_abnormal_hair_follicle0.71688915
111MP0005167_abnormal_blood-brain_barrier0.71564307
112MP0010307_abnormal_tumor_latency0.71377194
113MP0003011_delayed_dark_adaptation0.69158002
114MP0000609_abnormal_liver_physiology0.68158376
115MP0003690_abnormal_glial_cell0.67603836
116MP0009765_abnormal_xenobiotic_induced0.66347183
117MP0010386_abnormal_urinary_bladder0.64354970
118MP0003453_abnormal_keratinocyte_physiol0.63573550
119MP0000249_abnormal_blood_vessel0.61987909
120MP0008874_decreased_physiological_sensi0.60160428
121MP0001501_abnormal_sleep_pattern0.59822021
122MP0003646_muscle_fatigue0.55799188
123MP0003091_abnormal_cell_migration0.55078404
124MP0002136_abnormal_kidney_physiology0.53983552
125MP0005381_digestive/alimentary_phenotyp0.49385416

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of the heme biosynthetic pathway (HP:0010472)6.04215867
2Stomatitis (HP:0010280)5.24825480
3Nasal polyposis (HP:0100582)4.51500078
4Mediastinal lymphadenopathy (HP:0100721)4.24574162
5Abnormality of the nasal mucosa (HP:0000433)4.13257731
6Keratoconjunctivitis sicca (HP:0001097)4.11747691
7Elevated erythrocyte sedimentation rate (HP:0003565)4.07291599
8Recurrent bronchitis (HP:0002837)4.02138925
9Chronic otitis media (HP:0000389)3.90654438
10Poikilocytosis (HP:0004447)3.87853180
11Keratoconjunctivitis (HP:0001096)3.84598821
12Encephalitis (HP:0002383)3.84070158
13Gastrointestinal infarctions (HP:0005244)3.31693468
14Recurrent abscess formation (HP:0002722)3.26550671
15Myositis (HP:0100614)3.23527265
16Petechiae (HP:0000967)3.21832092
17Hemoptysis (HP:0002105)3.20281803
18Abnormal number of erythroid precursors (HP:0012131)3.12826758
19Chronic obstructive pulmonary disease (HP:0006510)3.11931827
20Obstructive lung disease (HP:0006536)3.11931827
21Type I transferrin isoform profile (HP:0003642)3.11506646
22Increased IgE level (HP:0003212)3.11504910
23Abnormality of T cell physiology (HP:0011840)3.10274417
24Bronchitis (HP:0012387)3.10081432
25Reduced antithrombin III activity (HP:0001976)3.09510382
26Hypochromic microcytic anemia (HP:0004840)3.09425145
27Gangrene (HP:0100758)3.07500198
28Eczematoid dermatitis (HP:0000976)3.06670108
29Abnormal delayed hypersensitivity skin test (HP:0002963)3.01763951
30Lymphopenia (HP:0001888)2.98150801
31Recurrent viral infections (HP:0004429)2.97134347
32Abnormality of cells of the erythroid lineage (HP:0012130)2.94223221
33Interstitial pulmonary disease (HP:0006530)2.90864891
34Gastrointestinal stroma tumor (HP:0100723)2.90722130
35IgM deficiency (HP:0002850)2.90431570
36Abnormality of cells of the lymphoid lineage (HP:0012140)2.86988665
37Thrombocytosis (HP:0001894)2.85424120
38Eosinophilia (HP:0001880)2.83593709
39Recurrent bacterial skin infections (HP:0005406)2.82990551
40Increased IgM level (HP:0003496)2.81989711
41Leukocytosis (HP:0001974)2.81462812
42Vacuolated lymphocytes (HP:0001922)2.78639307
43Microcytic anemia (HP:0001935)2.77533422
44Severe combined immunodeficiency (HP:0004430)2.76036301
45Granulocytopenia (HP:0001913)2.75134206
46Arterial thrombosis (HP:0004420)2.73285885
47Recurrent fungal infections (HP:0002841)2.69807510
48Abnormality of the pleura (HP:0002103)2.68721832
49Autoimmune thrombocytopenia (HP:0001973)2.67937802
50Anorexia (HP:0002039)2.66571699
51Osteomalacia (HP:0002749)2.63955512
52Prolonged bleeding time (HP:0003010)2.63538603
53Recurrent cutaneous fungal infections (HP:0011370)2.62908442
54Chronic mucocutaneous candidiasis (HP:0002728)2.62908442
55Systemic lupus erythematosus (HP:0002725)2.61416342
56Abnormal protein glycosylation (HP:0012346)2.60154218
57Abnormal glycosylation (HP:0012345)2.60154218
58Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.60154218
59Abnormal protein N-linked glycosylation (HP:0012347)2.60154218
60Abnormality of eosinophils (HP:0001879)2.57985358
61Abnormality of T cells (HP:0002843)2.57409047
62Hyperinsulinemic hypoglycemia (HP:0000825)2.55817345
63Flat capital femoral epiphysis (HP:0003370)2.53384590
64Pulmonary embolism (HP:0002204)2.52367550
65Reticulocytosis (HP:0001923)2.51241868
66Orchitis (HP:0100796)2.50256134
67Acanthocytosis (HP:0001927)2.49162698
68Chronic diarrhea (HP:0002028)2.48654938
69Chronic sinusitis (HP:0011109)2.48431386
70Hypochromic anemia (HP:0001931)2.44880452
71Agammaglobulinemia (HP:0004432)2.41134578
72Vasculitis (HP:0002633)2.39115091
73Hypergammaglobulinemia (HP:0010702)2.35862259
74Chest pain (HP:0100749)2.35687182
75Abnormality of macrophages (HP:0004311)2.35368912
76Loss of speech (HP:0002371)2.34465339
77Epistaxis (HP:0000421)2.33918449
78Pustule (HP:0200039)2.33504103
79Keratitis (HP:0000491)2.31766155
80Inflammation of the large intestine (HP:0002037)2.31168551
81Aplastic anemia (HP:0001915)2.29768451
82Dysostosis multiplex (HP:0000943)2.29428107
83Autoimmune hemolytic anemia (HP:0001890)2.29188655
84Polyneuropathy (HP:0001271)2.29174671
85Colitis (HP:0002583)2.26211437
86Recurrent skin infections (HP:0001581)2.25738831
87Spontaneous hematomas (HP:0007420)2.25394666
88Gastrointestinal inflammation (HP:0004386)2.24334997
89Sepsis (HP:0100806)2.24172032
90Parakeratosis (HP:0001036)2.24011871
91Abnormality of the pericardium (HP:0001697)2.23271626
92Recurrent gram-negative bacterial infections (HP:0005420)2.22833184
93Purpura (HP:0000979)2.18705174
94Recurrent pneumonia (HP:0006532)2.17590945
95Abnormality of the intrinsic pathway (HP:0010989)2.17396227
96Poor head control (HP:0002421)2.14809381
97Aplasia/Hypoplasia of the sacrum (HP:0008517)2.14313300
98Arthralgia (HP:0002829)2.12089168
99Skin rash (HP:0000988)2.12083623
100Disinhibition (HP:0000734)2.11690485
101Abnormality of reticulocytes (HP:0004312)2.10981770
102Gingivitis (HP:0000230)2.09527182
103Abnormality of T cell number (HP:0011839)2.09200043
104Cellulitis (HP:0100658)2.08400894
105Glomerulopathy (HP:0100820)2.08339542
106Osteomyelitis (HP:0002754)2.07986256
107Abnormality of the prostate (HP:0008775)2.06341444
108Lymphoma (HP:0002665)2.06264382
109IgG deficiency (HP:0004315)2.05508377
110Thyroiditis (HP:0100646)2.05322094
111Verrucae (HP:0200043)2.05044054
112Papilloma (HP:0012740)2.05044054
113Meningitis (HP:0001287)2.04726830
114Basal ganglia calcification (HP:0002135)2.04540330
115T lymphocytopenia (HP:0005403)2.04200683
116Abnormality of glycolipid metabolism (HP:0010969)2.02374466
117Abnormality of liposaccharide metabolism (HP:0010968)2.02374466
118Abnormality of glycosphingolipid metabolism (HP:0004343)2.02374466
119Gingival bleeding (HP:0000225)2.00964668
120IgA deficiency (HP:0002720)2.00904397
121Increased serum ferritin (HP:0003281)2.00813379
122Urticaria (HP:0001025)2.00787199
123Periodontitis (HP:0000704)2.00364255
124Recurrent sinusitis (HP:0011108)2.00177206
125Pallor (HP:0000980)1.98141608
126Urinary glycosaminoglycan excretion (HP:0003541)1.96648089
127Mucopolysacchariduria (HP:0008155)1.96648089
128Cheilitis (HP:0100825)1.95729270
129Cutaneous photosensitivity (HP:0000992)1.94826048
130Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.93904283
13111 pairs of ribs (HP:0000878)1.93839034
132B lymphocytopenia (HP:0010976)1.93373932
133Abnormality of B cell number (HP:0010975)1.93373932
134Increased neuronal autofluorescent lipopigment (HP:0002074)1.93033476
135Panhypogammaglobulinemia (HP:0003139)1.92843802
136Retrobulbar optic neuritis (HP:0100654)1.90703113
137Optic neuritis (HP:0100653)1.90703113
138Irregular vertebral endplates (HP:0003301)1.90677321
139Hyperbilirubinemia (HP:0002904)1.90235391
140Pulmonary infiltrates (HP:0002113)1.85122128
141Joint swelling (HP:0001386)1.83973138
142Combined immunodeficiency (HP:0005387)1.83700046
143Bronchiectasis (HP:0002110)1.83123861
144Diaphragmatic weakness (HP:0009113)1.81257143

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ERN13.85923550
2NME23.26630660
3CDK122.96414400
4TBK12.83233135
5IKBKE2.82632324
6JAK32.77203487
7TYK22.59547740
8KIT2.59027335
9MAP4K12.41529679
10TAOK32.13477682
11ZAP702.04678920
12FLT32.01186633
13MAP3K141.98686920
14IRAK41.98381082
15IRAK31.95278575
16PRPF4B1.88353946
17MAP3K111.86925322
18PIM21.84572802
19TAOK21.84167672
20TGFBR21.83592018
21IKBKB1.67168663
22BLK1.66116224
23TLK11.65439771
24TXK1.64099007
25HIPK21.58348866
26BMPR21.56660202
27SIK31.54883475
28ADRBK21.53978405
29FES1.53839976
30FGFR41.53443735
31TESK21.51827932
32SYK1.51792142
33PASK1.51176747
34STK101.50855458
35TAOK11.50547121
36GRK61.49371873
37JAK11.42855732
38CSF1R1.41815454
39MAPK151.34600466
40FGFR31.28207819
41TEC1.24835993
42CHUK1.22822657
43BTK1.21518260
44PIM11.21013152
45FGR1.17568813
46STK41.17322770
47VRK11.17305781
48INSRR1.15817677
49RPS6KA51.15066320
50MATK1.09905541
51PRKG21.09310041
52MST41.05557838
53CSK1.03517797
54GRK51.01331770
55RPS6KA41.01005071
56DYRK30.98595844
57GRK10.98168813
58NLK0.96259034
59KDR0.93415690
60EPHA30.88574665
61LYN0.87412970
62RIPK10.87395632
63JAK20.85973266
64LCK0.83052488
65MAP3K30.80978225
66BRSK20.80526947
67SIK20.78186810
68MAP2K30.76767145
69EIF2AK10.76096651
70ZAK0.73555943
71CDC42BPA0.69871640
72GRK70.69052896
73IRAK10.68233193
74LRRK20.68086635
75EIF2AK20.67141668
76PIK3CG0.65815197
77IRAK20.63085735
78SCYL20.62237794
79PRKCD0.61477089
80MAPKAPK30.60632387
81MOS0.60158466
82DYRK1B0.60110025
83CLK10.59908575
84CAMKK20.58913816
85MAP3K50.57425401
86MAP3K120.57158004
87PDK10.55066609
88EIF2AK30.54256417
89MAPK110.54119706
90ABL20.53934798
91MAPK70.51691060
92HCK0.51561881
93TGFBR10.51309741
94SIK10.51090111
95PRKD20.50265838
96FYN0.48247846
97ITK0.47849923
98EPHB10.46698447
99MUSK0.46466893
100CDK70.46237697
101BCKDK0.45732725
102MAP3K80.44693317
103AURKB0.44466350
104MAPKAPK20.44452641
105MAP3K100.42196336
106TRPM70.42058594
107MAP2K60.41427990
108ACVR1B0.40788413
109MAP3K130.40206005
110RPS6KB20.39160738
111CDK90.37960592
112CDK40.37150205
113MARK30.36565507
114RIPK40.35534893
115DDR20.34433691
116PKN10.32940788
117NEK90.30689688
118INSR0.29106183
119PRKCQ0.28483085
120MAP3K10.28441207
121TNK20.27190476
122EGFR0.27019204
123MAPK30.26033472
124ABL10.24160914
125MAPK120.20729493
126CAMKK10.20235340
127STK240.20088363
128MAPK40.18416846
129DAPK30.18221188
130PTK2B0.16889737
131PDPK10.14948422
132RPS6KA60.14057932

Predicted pathways (KEGG)

RankGene SetZ-score
1Protein export_Homo sapiens_hsa030603.61225065
2Maturity onset diabetes of the young_Homo sapiens_hsa049503.11308054
3Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.53288644
4RIG-I-like receptor signaling pathway_Homo sapiens_hsa046222.43821958
5Intestinal immune network for IgA production_Homo sapiens_hsa046722.40117036
6Primary immunodeficiency_Homo sapiens_hsa053402.36554540
7Antigen processing and presentation_Homo sapiens_hsa046122.31485481
8Allograft rejection_Homo sapiens_hsa053302.19547971
9Systemic lupus erythematosus_Homo sapiens_hsa053222.17438261
10Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008602.16454667
11Measles_Homo sapiens_hsa051622.10349652
12NF-kappa B signaling pathway_Homo sapiens_hsa040642.07621171
13Leishmaniasis_Homo sapiens_hsa051401.96247873
14Ribosome_Homo sapiens_hsa030101.94254716
15Herpes simplex infection_Homo sapiens_hsa051681.86435044
16Hematopoietic cell lineage_Homo sapiens_hsa046401.83379254
17Other glycan degradation_Homo sapiens_hsa005111.83343798
18Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.82783023
19Malaria_Homo sapiens_hsa051441.77153063
20Toll-like receptor signaling pathway_Homo sapiens_hsa046201.72930430
21Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.69684589
22Type I diabetes mellitus_Homo sapiens_hsa049401.67215712
23Legionellosis_Homo sapiens_hsa051341.64918013
24Influenza A_Homo sapiens_hsa051641.57558604
25Folate biosynthesis_Homo sapiens_hsa007901.54180979
26Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.50532918
27Graft-versus-host disease_Homo sapiens_hsa053321.50249716
28Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.49730531
29Jak-STAT signaling pathway_Homo sapiens_hsa046301.43001958
30Glycosaminoglycan degradation_Homo sapiens_hsa005311.26763585
31SNARE interactions in vesicular transport_Homo sapiens_hsa041301.26021914
32Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.22283238
33DNA replication_Homo sapiens_hsa030301.21507827
34Asthma_Homo sapiens_hsa053101.16592313
35N-Glycan biosynthesis_Homo sapiens_hsa005101.16460922
36Osteoclast differentiation_Homo sapiens_hsa043801.15782830
37NOD-like receptor signaling pathway_Homo sapiens_hsa046211.15188180
38Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.15184021
39Lysosome_Homo sapiens_hsa041421.13762855
40Viral carcinogenesis_Homo sapiens_hsa052031.11653794
41TNF signaling pathway_Homo sapiens_hsa046681.05707989
42Apoptosis_Homo sapiens_hsa042101.04965396
43Pertussis_Homo sapiens_hsa051331.04163130
44Toxoplasmosis_Homo sapiens_hsa051451.03622871
45Hepatitis B_Homo sapiens_hsa051611.03042100
46Transcriptional misregulation in cancer_Homo sapiens_hsa052021.02628006
47Homologous recombination_Homo sapiens_hsa034400.99112538
48Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.99064550
49Autoimmune thyroid disease_Homo sapiens_hsa053200.94056472
50p53 signaling pathway_Homo sapiens_hsa041150.93146921
51Galactose metabolism_Homo sapiens_hsa000520.91237542
52Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.90791530
53B cell receptor signaling pathway_Homo sapiens_hsa046620.90353605
54Alcoholism_Homo sapiens_hsa050340.90008104
55Phagosome_Homo sapiens_hsa041450.88848979
56ABC transporters_Homo sapiens_hsa020100.87902613
57Hepatitis C_Homo sapiens_hsa051600.86220775
58Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.85347495
59Tuberculosis_Homo sapiens_hsa051520.83158506
60Arachidonic acid metabolism_Homo sapiens_hsa005900.82421312
61Proteasome_Homo sapiens_hsa030500.79141097
62Acute myeloid leukemia_Homo sapiens_hsa052210.78322915
63Prolactin signaling pathway_Homo sapiens_hsa049170.75181692
64Base excision repair_Homo sapiens_hsa034100.74811298
65Staphylococcus aureus infection_Homo sapiens_hsa051500.70006933
66Mismatch repair_Homo sapiens_hsa034300.69608022
67Pyrimidine metabolism_Homo sapiens_hsa002400.68159094
68Linoleic acid metabolism_Homo sapiens_hsa005910.68119193
69Chemokine signaling pathway_Homo sapiens_hsa040620.66461334
70alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.65983944
71African trypanosomiasis_Homo sapiens_hsa051430.65023267
72T cell receptor signaling pathway_Homo sapiens_hsa046600.64987116
73Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.62769105
74Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.61797295
75Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.59257502
76Rheumatoid arthritis_Homo sapiens_hsa053230.58421788
77Shigellosis_Homo sapiens_hsa051310.58032434
78Selenocompound metabolism_Homo sapiens_hsa004500.56748982
79Caffeine metabolism_Homo sapiens_hsa002320.55241834
80Fanconi anemia pathway_Homo sapiens_hsa034600.55151151
81Nucleotide excision repair_Homo sapiens_hsa034200.54030478
82Sulfur relay system_Homo sapiens_hsa041220.51880543
83Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.50264626
84Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.49885894
85Thyroid cancer_Homo sapiens_hsa052160.49716589
86Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.49300800
87Platelet activation_Homo sapiens_hsa046110.47742010
88Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.47675849
89HTLV-I infection_Homo sapiens_hsa051660.47541765
90Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.45891281
91Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.43119434
92Epstein-Barr virus infection_Homo sapiens_hsa051690.42551148
93Sulfur metabolism_Homo sapiens_hsa009200.42133034
94AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.41478228
95Cell cycle_Homo sapiens_hsa041100.41292366
96VEGF signaling pathway_Homo sapiens_hsa043700.39970520
97Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.38433666
98Small cell lung cancer_Homo sapiens_hsa052220.38302211
99Sphingolipid metabolism_Homo sapiens_hsa006000.38047592
100Salmonella infection_Homo sapiens_hsa051320.37588100
101Regulation of autophagy_Homo sapiens_hsa041400.36819582
102Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.35756468
103Viral myocarditis_Homo sapiens_hsa054160.35395030
104Pancreatic cancer_Homo sapiens_hsa052120.35369235
105Adipocytokine signaling pathway_Homo sapiens_hsa049200.35028800
106Chronic myeloid leukemia_Homo sapiens_hsa052200.33920751
107Leukocyte transendothelial migration_Homo sapiens_hsa046700.33415216
108Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.32404621
109Non-homologous end-joining_Homo sapiens_hsa034500.30864317
110Endocytosis_Homo sapiens_hsa041440.29211493
111Type II diabetes mellitus_Homo sapiens_hsa049300.28706163
112Sphingolipid signaling pathway_Homo sapiens_hsa040710.27963505
113FoxO signaling pathway_Homo sapiens_hsa040680.25402112
114Dorso-ventral axis formation_Homo sapiens_hsa043200.24999024
115Insulin resistance_Homo sapiens_hsa049310.22803042
116Prion diseases_Homo sapiens_hsa050200.21211987
117Amoebiasis_Homo sapiens_hsa051460.20528597
118Neurotrophin signaling pathway_Homo sapiens_hsa047220.19648319
119Non-small cell lung cancer_Homo sapiens_hsa052230.18098424
120Collecting duct acid secretion_Homo sapiens_hsa049660.17594236
121MAPK signaling pathway_Homo sapiens_hsa040100.17308108
122Complement and coagulation cascades_Homo sapiens_hsa046100.13865892
123HIF-1 signaling pathway_Homo sapiens_hsa040660.13471540
124Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.13032509
125Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.12495504
126Renal cell carcinoma_Homo sapiens_hsa052110.06963139
127Bladder cancer_Homo sapiens_hsa052190.06563309
128Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.05111615
129Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.03701620
130Carbohydrate digestion and absorption_Homo sapiens_hsa049730.02831721

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