ISG20L2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a 3'-5' exoribonuclease that may be involved in the processing of the 12S pre-rRNA. Pseudogenes have been identified on chromosomes 6 and 11. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1polyketide metabolic process (GO:0030638)6.83412442
2doxorubicin metabolic process (GO:0044598)6.83412442
3daunorubicin metabolic process (GO:0044597)6.83412442
4protein localization to kinetochore (GO:0034501)5.98152369
5sperm motility (GO:0030317)5.90750897
6DNA packaging (GO:0006323)5.58607414
7single strand break repair (GO:0000012)5.28149386
8nuclear pore complex assembly (GO:0051292)5.18302807
9acrosome reaction (GO:0007340)5.17870311
10regulation of nuclear cell cycle DNA replication (GO:0033262)5.03270544
11nuclear pore organization (GO:0006999)4.79918638
12regulation of telomere maintenance via telomerase (GO:0032210)4.77769242
13protein localization to chromosome, centromeric region (GO:0071459)4.74491512
14mitotic sister chromatid segregation (GO:0000070)4.67902500
15regulation of mammary gland epithelial cell proliferation (GO:0033599)4.64892198
16microtubule depolymerization (GO:0007019)4.64834375
17DNA replication-dependent nucleosome assembly (GO:0006335)4.64494245
18DNA replication-dependent nucleosome organization (GO:0034723)4.64494245
19negative regulation of G2/M transition of mitotic cell cycle (GO:0010972)4.64053991
20spermatid development (GO:0007286)4.59913540
21fusion of sperm to egg plasma membrane (GO:0007342)4.58612591
22negative regulation of epidermis development (GO:0045683)4.58544826
23sperm-egg recognition (GO:0035036)4.58083651
24histone H4-K12 acetylation (GO:0043983)4.55279450
25maintenance of protein location in nucleus (GO:0051457)4.50464386
26response to pheromone (GO:0019236)4.41706062
27regulation of centriole replication (GO:0046599)4.39447062
28heterochromatin organization (GO:0070828)4.37916744
29negative regulation of cell cycle G2/M phase transition (GO:1902750)4.37739696
30spermatid nucleus differentiation (GO:0007289)4.35857602
31DNA replication checkpoint (GO:0000076)4.34963421
32binding of sperm to zona pellucida (GO:0007339)4.32316814
33negative regulation of telomerase activity (GO:0051974)4.31257225
34histone H4-K8 acetylation (GO:0043982)4.30759773
35histone H4-K5 acetylation (GO:0043981)4.30759773
36protein polyglutamylation (GO:0018095)4.25895577
37rRNA transcription (GO:0009303)4.25329092
38aminoglycoside antibiotic metabolic process (GO:0030647)4.22856157
39regulation of response to osmotic stress (GO:0047484)4.16279780
40sister chromatid segregation (GO:0000819)4.15972163
41somite rostral/caudal axis specification (GO:0032525)4.15582914
42DNA unwinding involved in DNA replication (GO:0006268)4.13276943
43positive regulation of DNA-dependent DNA replication (GO:2000105)4.07418448
44chromatin assembly (GO:0031497)4.05221054
45centriole replication (GO:0007099)4.00253045
46negative regulation of intracellular estrogen receptor signaling pathway (GO:0033147)3.98504569
47rRNA methylation (GO:0031167)3.92211449
48muscle organ morphogenesis (GO:0048644)3.91506223
49pore complex assembly (GO:0046931)3.90906500
50rRNA modification (GO:0000154)3.76777282
51DNA replication initiation (GO:0006270)3.73865418
52DNA duplex unwinding (GO:0032508)3.73247770
53DNA geometric change (GO:0032392)3.70202410
54negative regulation of epidermal cell differentiation (GO:0045605)3.68526620
55tRNA methylation (GO:0030488)3.67109314
56cell-cell recognition (GO:0009988)3.60221314
57regulation of translation in response to stress (GO:0043555)3.60143554
58sperm capacitation (GO:0048240)3.59986517
59pre-miRNA processing (GO:0031054)3.59633517
60multicellular organism reproduction (GO:0032504)3.57603732
61interferon-gamma production (GO:0032609)3.53707729
62regulation of MHC class I biosynthetic process (GO:0045343)3.53187526
63negative regulation of telomere maintenance (GO:0032205)3.52440444
64RNA stabilization (GO:0043489)3.51267370
65mRNA stabilization (GO:0048255)3.51267370
66formation of translation preinitiation complex (GO:0001731)3.50431214
67centriole assembly (GO:0098534)3.50086898
68notochord development (GO:0030903)3.48844546
69microtubule polymerization or depolymerization (GO:0031109)3.46030731
70mitotic chromosome condensation (GO:0007076)3.44917130
71maturation of SSU-rRNA (GO:0030490)3.42759031
72maturation of 5.8S rRNA (GO:0000460)3.42244028
73male gamete generation (GO:0048232)3.39994956
74spermatogenesis (GO:0007283)3.39475559
75histone H4-K16 acetylation (GO:0043984)3.38478193
76rRNA processing (GO:0006364)3.36891123
77regulation of gene silencing by miRNA (GO:0060964)3.35057935
78regulation of gene silencing by RNA (GO:0060966)3.35057935
79regulation of posttranscriptional gene silencing (GO:0060147)3.35057935
80rRNA metabolic process (GO:0016072)3.32190178
81ribosomal small subunit biogenesis (GO:0042274)3.29186822
82mitotic nuclear envelope disassembly (GO:0007077)3.29041063
83reproduction (GO:0000003)3.28045636
84histone exchange (GO:0043486)3.27207693
85plasma membrane fusion (GO:0045026)3.22549247
86cellular ketone body metabolic process (GO:0046950)3.20857543
87ribosome assembly (GO:0042255)3.17924594
88gamete generation (GO:0007276)3.14428888
89regulation of telomere maintenance (GO:0032204)3.12596274
90RNA methylation (GO:0001510)3.11054131
91tRNA modification (GO:0006400)3.08355240
92regulation of apoptotic process involved in morphogenesis (GO:1902337)3.06924794
93regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.05965493
94sexual reproduction (GO:0019953)3.04963138
95spliceosomal snRNP assembly (GO:0000387)3.02659569
96regulation of mitochondrial translation (GO:0070129)3.02237653
97membrane disassembly (GO:0030397)3.01716625
98nuclear envelope disassembly (GO:0051081)3.01716625
99regulation of cilium movement (GO:0003352)3.01024349
100DNA conformation change (GO:0071103)3.00936868
101primitive streak formation (GO:0090009)2.99779960
102nucleus organization (GO:0006997)2.98920735
103* ribosome biogenesis (GO:0042254)2.97873179
104regulation of DNA-dependent DNA replication (GO:0090329)2.97166799
105folic acid-containing compound biosynthetic process (GO:0009396)2.96927429
106regulation of centrosome cycle (GO:0046605)2.95119872
107trophectodermal cell differentiation (GO:0001829)2.95003188
108transcription elongation from RNA polymerase III promoter (GO:0006385)2.94722380
109termination of RNA polymerase III transcription (GO:0006386)2.94722380
110branching involved in mammary gland duct morphogenesis (GO:0060444)2.94586674
111chromatin assembly or disassembly (GO:0006333)2.93883489
112pseudouridine synthesis (GO:0001522)2.93859091
113regulation of double-strand break repair (GO:2000779)2.93841420
114spindle assembly (GO:0051225)2.93793841
115phosphatidylethanolamine biosynthetic process (GO:0006646)2.91817851
116intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator (GO:0042771)2.90291474
117positive regulation of protein deacetylation (GO:0090312)2.90041768
118DNA damage response, detection of DNA damage (GO:0042769)2.89576676
119cell fate commitment involved in formation of primary germ layer (GO:0060795)2.89017758
120mitochondrial RNA metabolic process (GO:0000959)2.88281914
121ncRNA processing (GO:0034470)2.88099006
122peptidyl-histidine modification (GO:0018202)2.86876637
123spliceosomal complex assembly (GO:0000245)2.86040301
124chromatin silencing (GO:0006342)2.85317334
125ketone body metabolic process (GO:1902224)2.84563132
126protein-DNA complex disassembly (GO:0032986)2.83625118
127nucleosome disassembly (GO:0006337)2.83625118
128DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla2.82705024
129ncRNA metabolic process (GO:0034660)2.80789407
130negative regulation of gene silencing (GO:0060969)2.80438012
131microtubule severing (GO:0051013)2.79719478
132protein localization to chromosome (GO:0034502)2.79537640
133proteasome assembly (GO:0043248)2.78830116
134regulation of centrosome duplication (GO:0010824)2.77171395
135tRNA processing (GO:0008033)2.74575744
136mitotic G1 DNA damage checkpoint (GO:0031571)2.73643914
137regulation of gene silencing (GO:0060968)2.73119739
138DNA strand elongation involved in DNA replication (GO:0006271)2.73067937
139* ribonucleoprotein complex biogenesis (GO:0022613)2.72259736
140IMP biosynthetic process (GO:0006188)2.72252962
141mitotic metaphase plate congression (GO:0007080)2.71983830
142nucleobase biosynthetic process (GO:0046112)2.71956899
143chromosome condensation (GO:0030261)2.71940158
144chaperone-mediated protein complex assembly (GO:0051131)2.71665853
145phosphatidylethanolamine metabolic process (GO:0046337)2.70688174
146ribosomal large subunit biogenesis (GO:0042273)2.69940049
147regulation of intracellular estrogen receptor signaling pathway (GO:0033146)2.66676422
148nucleoside transmembrane transport (GO:1901642)2.66462295
149mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.64509079
150RNA modification (GO:0009451)2.64270946
151single fertilization (GO:0007338)2.64230881
152mitotic G1/S transition checkpoint (GO:0044819)2.63527770
153double-strand break repair via homologous recombination (GO:0000724)2.63389075
154recombinational repair (GO:0000725)2.63344440
155positive regulation of histone deacetylation (GO:0031065)2.63109022
156establishment of protein localization to mitochondrial membrane (GO:0090151)2.62772917
157regulation of histone H3-K9 methylation (GO:0051570)2.62754980
158regulation of telomerase activity (GO:0051972)2.62505602
159mitotic G2/M transition checkpoint (GO:0044818)2.62427850
160DNA strand elongation (GO:0022616)2.60890575
161regulation of double-strand break repair via homologous recombination (GO:0010569)2.60737215
162piRNA metabolic process (GO:0034587)2.59376820
163polyamine biosynthetic process (GO:0006596)2.59362461
164DNA damage response, signal transduction resulting in transcription (GO:0042772)2.58856178
165regulation of mitotic spindle checkpoint (GO:1903504)2.58249007
166regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.58249007
167protein targeting to Golgi (GO:0000042)2.58238392
168somatic hypermutation of immunoglobulin genes (GO:0016446)2.57089636
169somatic diversification of immune receptors via somatic mutation (GO:0002566)2.57089636
170meiotic chromosome segregation (GO:0045132)2.56541104
171tRNA metabolic process (GO:0006399)2.56246672
172regulation of mRNA stability (GO:0043488)2.56051216
173establishment of protein localization to Golgi (GO:0072600)2.55907176
174germ cell development (GO:0007281)2.55641928
1753-UTR-mediated mRNA stabilization (GO:0070935)2.54883731
176pteridine-containing compound biosynthetic process (GO:0042559)2.54262039
177telomere maintenance via semi-conservative replication (GO:0032201)2.53208419

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human8.28601066
2KLF5_18264089_ChIP-ChIP_MESCs_Mouse4.39410033
3KLF4_18264089_ChIP-ChIP_MESCs_Mouse4.39410033
4KLF2_18264089_ChIP-ChIP_MESCs_Mouse4.39410033
5BP1_19119308_ChIP-ChIP_Hs578T_Human3.80925291
6E2F4_17652178_ChIP-ChIP_JURKAT_Human3.65922942
7FOXM1_23109430_ChIP-Seq_U2OS_Human3.45402779
8SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.36486607
9TP63_19390658_ChIP-ChIP_HaCaT_Human3.20795762
10NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.12549196
11MYCN_21190229_ChIP-Seq_SHEP-21N_Human3.05939860
12MYC_18555785_ChIP-Seq_MESCs_Mouse3.03445046
13FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.77139459
14SMAD1_18555785_ChIP-Seq_MESCs_Mouse2.49259266
15* MYC_19079543_ChIP-ChIP_MESCs_Mouse2.36883499
16HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.29411811
17* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.27315104
18NACC1_18358816_ChIP-ChIP_MESCs_Mouse2.22832919
19POU5F1_18700969_ChIP-ChIP_MESCs_Mouse2.20415313
20* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.17562445
21MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.16545390
22THAP11_20581084_ChIP-Seq_MESCs_Mouse2.16161765
23EGR1_19374776_ChIP-ChIP_THP-1_Human2.14207638
24MYC_22102868_ChIP-Seq_BL_Human2.09427299
25SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.97966923
26MYC_18358816_ChIP-ChIP_MESCs_Mouse1.92671868
27TCF3_18692474_ChIP-Seq_MEFs_Mouse1.91063988
28TCF3_18692474_ChIP-Seq_MESCs_Mouse1.89828163
29* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.83042385
30ZNF274_21170338_ChIP-Seq_K562_Hela1.78783850
31CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.72497616
32NANOG_18555785_ChIP-Seq_MESCs_Mouse1.70501512
33PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.69712479
34STAT3_1855785_ChIP-Seq_MESCs_Mouse1.67030687
35NOTCH1_21737748_ChIP-Seq_TLL_Human1.65117874
36KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.63342076
37EST1_17652178_ChIP-ChIP_JURKAT_Human1.61733917
38E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.61586760
39KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.60192821
40POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.58022585
41CREB1_15753290_ChIP-ChIP_HEK293T_Human1.54354104
42NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.53934838
43NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.50112994
44MYC_18940864_ChIP-ChIP_HL60_Human1.49857970
45PADI4_21655091_ChIP-ChIP_MCF-7_Human1.49117478
46* POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.47408015
47KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.46961897
48CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.45396146
49SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.45084374
50FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.44450668
51AR_21909140_ChIP-Seq_LNCAP_Human1.43693983
52EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.43532328
53IRF1_19129219_ChIP-ChIP_H3396_Human1.41720779
54NELFA_20434984_ChIP-Seq_ESCs_Mouse1.41638257
55ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.41281635
56SOX2_18555785_ChIP-Seq_MESCs_Mouse1.40540392
57FOXP3_21729870_ChIP-Seq_TREG_Human1.37166899
58* XRN2_22483619_ChIP-Seq_HELA_Human1.36841785
59RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.36415479
60BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.35203336
61HIF1A_21447827_ChIP-Seq_MCF-7_Human1.34612640
62ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.33891755
63NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.33263455
64SRF_21415370_ChIP-Seq_HL-1_Mouse1.30720306
65ERA_21632823_ChIP-Seq_H3396_Human1.30483554
66YY1_21170310_ChIP-Seq_MESCs_Mouse1.29971099
67E2F1_21310950_ChIP-Seq_MCF-7_Human1.29916241
68EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.28871582
69DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.28870425
70ETS1_20019798_ChIP-Seq_JURKAT_Human1.25159364
71YY1_22570637_ChIP-Seq_MALME-3M_Human1.24131290
72* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.23691935
73SCL_19346495_ChIP-Seq_HPC-7_Human1.21350061
74CIITA_25753668_ChIP-Seq_RAJI_Human1.21203245
75HOXB4_20404135_ChIP-ChIP_EML_Mouse1.20090791
76SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.18872837
77PHF8_20622854_ChIP-Seq_HELA_Human1.18729978
78VDR_23849224_ChIP-Seq_CD4+_Human1.18455709
79E2F1_18555785_ChIP-Seq_MESCs_Mouse1.18397210
80ELF1_20517297_ChIP-Seq_JURKAT_Human1.17752623
81POU5F1_16518401_ChIP-PET_MESCs_Mouse1.17638247
82GABP_17652178_ChIP-ChIP_JURKAT_Human1.17587427
83RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.16816067
84RAC3_21632823_ChIP-Seq_H3396_Human1.15828151
85* FOXP1_21924763_ChIP-Seq_HESCs_Human1.13735697
86* JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.13670411
87CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.13009050
88NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.12975759
89KDM5A_27292631_Chip-Seq_BREAST_Human1.12329550
90E2F1_20622854_ChIP-Seq_HELA_Human1.11375452
91TTF2_22483619_ChIP-Seq_HELA_Human1.10756432
92CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.10004725
93ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.09565423
94SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.09293612
95TCF3_18347094_ChIP-ChIP_MESCs_Mouse1.09106779
96TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.08905119
97NANOG_18692474_ChIP-Seq_MEFs_Mouse1.08837913
98NANOG_20526341_ChIP-Seq_ESCs_Human1.08802545
99DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.08540789
100* POU5F1_18692474_ChIP-Seq_MESCs_Mouse1.07317709
101TCF7_22412390_ChIP-Seq_EML_Mouse1.07261412
102KLF4_18555785_ChIP-Seq_MESCs_Mouse1.05447854
103NANOG_21062744_ChIP-ChIP_HESCs_Human1.05049594
104SALL1_21062744_ChIP-ChIP_HESCs_Human1.04834591
105NANOG_18692474_ChIP-Seq_MESCs_Mouse1.04056411
106PKCTHETA_26484144_Chip-Seq_BREAST_Human1.01204023
107SOX2_18692474_ChIP-Seq_MESCs_Mouse1.00786412
108OCT4_18692474_ChIP-Seq_MEFs_Mouse0.99812227
109KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.99811491
110SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.99399405
111HCFC1_20581084_ChIP-Seq_MESCs_Mouse0.99314553
112STAT6_21828071_ChIP-Seq_BEAS2B_Human0.99236852
113BCOR_27268052_Chip-Seq_Bcells_Human0.98855398
114PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.98344227
115CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.97813183
116P68_20966046_ChIP-Seq_HELA_Human0.97527180
117SOX2_18692474_ChIP-Seq_MEFs_Mouse0.95647079
118BCL6_27268052_Chip-Seq_Bcells_Human0.95465544
119NCOR1_26117541_ChIP-Seq_K562_Human0.95143341
120* GABP_19822575_ChIP-Seq_HepG2_Human0.94848923
121RBPJ_21746931_ChIP-Seq_IB4_Human0.94008857
122* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.93622176
123CTCF_20526341_ChIP-Seq_ESCs_Human0.93559873
124CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.93430062
125P53_21459846_ChIP-Seq_SAOS-2_Human0.93330996
126NANOG_16153702_ChIP-ChIP_HESCs_Human0.92170933
127ELF1_17652178_ChIP-ChIP_JURKAT_Human0.91832618
128P300_27268052_Chip-Seq_Bcells_Human0.91528392
129* ELF5_23300383_ChIP-Seq_T47D_Human0.91237601
130* ZFX_18555785_ChIP-Seq_MESCs_Mouse0.91003979
131FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.90617293
132VDR_21846776_ChIP-Seq_THP-1_Human0.90310072
133ELK1_19687146_ChIP-ChIP_HELA_Human0.90033238
134ELK1_22589737_ChIP-Seq_MCF10A_Human0.88955499
135ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.88846406
136HOXB7_26014856_ChIP-Seq_BT474_Human0.88462793
137FUS_26573619_Chip-Seq_HEK293_Human0.88151001
138PRDM14_21183938_ChIP-Seq_MESCs_Mouse0.88110183
139TDRD3_21172665_ChIP-Seq_MCF-7_Human0.87494934
140CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.87300715
141TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.87163676
142TAF2_19829295_ChIP-Seq_ESCs_Human0.86090823
143TFEB_21752829_ChIP-Seq_HELA_Human0.85053422
144DCP1A_22483619_ChIP-Seq_HELA_Human0.84883507
145MYB_26560356_Chip-Seq_TH1_Human0.84607446
146* GATA6_21074721_ChIP-Seq_CACO-2_Human0.83919061
147ZFP281_27345836_Chip-Seq_ESCs_Mouse0.81486522
148* SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.80638500
149E2F1_17053090_ChIP-ChIP_MCF-7_Human0.79538688
150YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.79351085

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005410_abnormal_fertilization6.31139269
2MP0008057_abnormal_DNA_replication4.04403748
3MP0004957_abnormal_blastocyst_morpholog3.37773268
4MP0004264_abnormal_extraembryonic_tissu3.10359133
5MP0006292_abnormal_olfactory_placode3.08998395
6MP0003718_maternal_effect2.90101323
7MP0002254_reproductive_system_inflammat2.89329353
8MP0003890_abnormal_embryonic-extraembry2.86373980
9MP0001929_abnormal_gametogenesis2.73824653
10MP0003698_abnormal_male_reproductive2.72833678
11MP0003011_delayed_dark_adaptation2.63983396
12MP0003111_abnormal_nucleus_morphology2.62505367
13MP0010094_abnormal_chromosome_stability2.61112582
14MP0010352_gastrointestinal_tract_polyps2.56874301
15MP0003077_abnormal_cell_cycle2.56360457
16MP0002396_abnormal_hematopoietic_system2.44593400
17MP0003878_abnormal_ear_physiology2.37707162
18MP0005377_hearing/vestibular/ear_phenot2.37707162
19MP0005075_abnormal_melanosome_morpholog2.35785724
20MP0003693_abnormal_embryo_hatching2.28412762
21MP0005394_taste/olfaction_phenotype2.16202377
22MP0005499_abnormal_olfactory_system2.16202377
23MP0003121_genomic_imprinting2.07236919
24MP0005380_embryogenesis_phenotype1.98339148
25MP0001672_abnormal_embryogenesis/_devel1.98339148
26MP0000350_abnormal_cell_proliferation1.97089326
27MP0002210_abnormal_sex_determination1.96652128
28MP0003705_abnormal_hypodermis_morpholog1.94068462
29MP0008877_abnormal_DNA_methylation1.85806250
30MP0008007_abnormal_cellular_replicative1.82663381
31MP0002088_abnormal_embryonic_growth/wei1.80401089
32MP0003984_embryonic_growth_retardation1.79972826
33MP0001293_anophthalmia1.76333809
34MP0003123_paternal_imprinting1.70752350
35MP0000490_abnormal_crypts_of1.68828051
36MP0008995_early_reproductive_senescence1.68713178
37MP0008058_abnormal_DNA_repair1.64246860
38MP0002161_abnormal_fertility/fecundity1.63691915
39MP0005379_endocrine/exocrine_gland_phen1.63234398
40MP0003122_maternal_imprinting1.59391795
41MP0001145_abnormal_male_reproductive1.56985143
42MP0001348_abnormal_lacrimal_gland1.56599307
43MP0002086_abnormal_extraembryonic_tissu1.52509490
44MP0002085_abnormal_embryonic_tissue1.50735383
45MP0010030_abnormal_orbit_morphology1.50302262
46MP0003646_muscle_fatigue1.50223872
47MP0008932_abnormal_embryonic_tissue1.50100827
48MP0005257_abnormal_intraocular_pressure1.49783740
49MP0001730_embryonic_growth_arrest1.49610078
50MP0002653_abnormal_ependyma_morphology1.48292864
51MP0002084_abnormal_developmental_patter1.42274758
52MP0002092_abnormal_eye_morphology1.42125237
53MP0004197_abnormal_fetal_growth/weight/1.40810914
54MP0000653_abnormal_sex_gland1.39494620
55MP0002332_abnormal_exercise_endurance1.37811464
56MP0001919_abnormal_reproductive_system1.35101279
57MP0003938_abnormal_ear_development1.34715194
58MP0002132_abnormal_respiratory_system1.33919604
59MP0005310_abnormal_salivary_gland1.28767546
60MP0001697_abnormal_embryo_size1.28612383
61MP0000313_abnormal_cell_death1.25390236
62MP0000678_abnormal_parathyroid_gland1.23623915
63MP0005083_abnormal_biliary_tract1.23547876
64MP0003786_premature_aging1.22065288
65MP0002277_abnormal_respiratory_mucosa1.21734442
66MP0003806_abnormal_nucleotide_metabolis1.21723627
67MP0001849_ear_inflammation1.20794936
68MP0005670_abnormal_white_adipose1.20498726
69MP0002938_white_spotting1.19458571
70MP0002932_abnormal_joint_morphology1.19398941
71MP0003136_yellow_coat_color1.19253623
72MP0004858_abnormal_nervous_system1.19252172
73MP0002080_prenatal_lethality1.18081971
74MP0009053_abnormal_anal_canal1.15387830
75MP0006035_abnormal_mitochondrial_morpho1.13616815
76MP0002163_abnormal_gland_morphology1.13199690
77MP0006082_CNS_inflammation1.11032345
78MP0004233_abnormal_muscle_weight1.09613758
79MP0001873_stomach_inflammation1.08608855
80MP0000049_abnormal_middle_ear1.08534679
81MP0002282_abnormal_trachea_morphology1.08435732
82MP0003315_abnormal_perineum_morphology1.07554224
83MP0008789_abnormal_olfactory_epithelium1.07159084
84MP0002019_abnormal_tumor_incidence1.07013758
85MP0004381_abnormal_hair_follicle1.06608144
86MP0004808_abnormal_hematopoietic_stem1.06433739
87MP0000428_abnormal_craniofacial_morphol1.06104752
88MP0000432_abnormal_head_morphology1.03946429
89MP0002234_abnormal_pharynx_morphology1.03615444
90MP0002127_abnormal_cardiovascular_syste1.02839994
91MP0008961_abnormal_basal_metabolism1.02827291
92MP0001485_abnormal_pinna_reflex1.02347543
93MP0009697_abnormal_copulation1.01994928
94MP0005248_abnormal_Harderian_gland1.00590735
95MP0000703_abnormal_thymus_morphology0.99469192
96MP0005451_abnormal_body_composition0.98869879
97MP0002722_abnormal_immune_system0.98394379
98MP0005389_reproductive_system_phenotype0.97445641
99MP0002233_abnormal_nose_morphology0.96260440
100MP0000762_abnormal_tongue_morphology0.96078796
101MP0002114_abnormal_axial_skeleton0.96004975
102MP0002398_abnormal_bone_marrow0.95719595
103MP0000613_abnormal_salivary_gland0.94710632
104MP0003935_abnormal_craniofacial_develop0.94493256
105MP0002160_abnormal_reproductive_system0.93230194
106MP0000689_abnormal_spleen_morphology0.93197157
107MP0003763_abnormal_thymus_physiology0.92813271
108MP0002102_abnormal_ear_morphology0.92122116
109MP0003119_abnormal_digestive_system0.91899112
110MP0005023_abnormal_wound_healing0.89882843
111MP0000858_altered_metastatic_potential0.89823405
112MP0010307_abnormal_tumor_latency0.88992031
113MP0005395_other_phenotype0.88463654
114MP0000383_abnormal_hair_follicle0.87215914
115MP0003937_abnormal_limbs/digits/tail_de0.85863890
116MP0005408_hypopigmentation0.85246331
117MP0002249_abnormal_larynx_morphology0.85102019
118MP0008770_decreased_survivor_rate0.84077521
119MP0000470_abnormal_stomach_morphology0.83585096
120MP0009703_decreased_birth_body0.83193426
121MP0001529_abnormal_vocalization0.82957519
122MP0002925_abnormal_cardiovascular_devel0.82763987
123MP0001286_abnormal_eye_development0.82728517
124MP0003755_abnormal_palate_morphology0.82523534
125MP0004133_heterotaxia0.82042255
126MP0001800_abnormal_humoral_immune0.79630655
127MP0002098_abnormal_vibrissa_morphology0.79513196
128MP0005266_abnormal_metabolism0.79332949
129MP0002429_abnormal_blood_cell0.78859347
130MP0003448_altered_tumor_morphology0.78650577
131MP0000377_abnormal_hair_follicle0.78079366
132MP0001727_abnormal_embryo_implantation0.77188680
133MP0009333_abnormal_splenocyte_physiolog0.77028361
134MP0000579_abnormal_nail_morphology0.76232067
135MP0005391_vision/eye_phenotype0.75203122
136MP0000427_abnormal_hair_cycle0.75127599
137MP0002111_abnormal_tail_morphology0.75109486
138MP0002405_respiratory_system_inflammati0.74900126
139MP0005076_abnormal_cell_differentiation0.74872329
140MP0002970_abnormal_white_adipose0.73878404
141MP0003183_abnormal_peptide_metabolism0.73089505
142MP0005508_abnormal_skeleton_morphology0.71427382
143MP0005253_abnormal_eye_physiology0.71323109
144MP0000358_abnormal_cell_content/0.71078995
145MP0000716_abnormal_immune_system0.70690172
146MP0003186_abnormal_redox_activity0.68644186
147MP0000631_abnormal_neuroendocrine_gland0.67964266
148MP0006036_abnormal_mitochondrial_physio0.67931106
149MP0003936_abnormal_reproductive_system0.67194557
150MP0001119_abnormal_female_reproductive0.63112316
151MP0003699_abnormal_female_reproductive0.62060880
152MP0005551_abnormal_eye_electrophysiolog0.59782428
153MP0002138_abnormal_hepatobiliary_system0.59142078
154MP0005645_abnormal_hypothalamus_physiol0.58945432

Predicted human phenotypes

RankGene SetZ-score
1Bilateral microphthalmos (HP:0007633)5.84215904
2Hypochromic microcytic anemia (HP:0004840)4.83165967
3Chromosomal breakage induced by crosslinking agents (HP:0003221)4.37681927
4Ependymoma (HP:0002888)4.35599480
5Rib fusion (HP:0000902)4.27882832
6Multiple enchondromatosis (HP:0005701)4.09775717
7Chromsome breakage (HP:0040012)3.96667141
8Hepatoblastoma (HP:0002884)3.73444158
9Severe visual impairment (HP:0001141)3.68616691
10Rhabdomyosarcoma (HP:0002859)3.60912520
11Nephroblastoma (Wilms tumor) (HP:0002667)3.52109709
12Neoplasm of striated muscle (HP:0009728)3.51714089
13Embryonal renal neoplasm (HP:0011794)3.24090151
14Chronic hepatic failure (HP:0100626)3.08023695
15Abnormal lung lobation (HP:0002101)3.03589553
16Abnormality of the lower motor neuron (HP:0002366)3.03281542
17Abnormality of the astrocytes (HP:0100707)2.94944454
18Astrocytoma (HP:0009592)2.94944454
19Meckel diverticulum (HP:0002245)2.93791687
20Impulsivity (HP:0100710)2.92163619
21Abnormality of the pons (HP:0007361)2.81679722
22Abnormality of the ileum (HP:0001549)2.81192569
23Rectovaginal fistula (HP:0000143)2.79014463
24Rectal fistula (HP:0100590)2.79014463
25Aplasia/Hypoplasia of the sacrum (HP:0008517)2.78935341
26Hypoplasia of the pons (HP:0012110)2.78527857
27Aplasia/Hypoplasia of the uvula (HP:0010293)2.78493557
28Partial duplication of thumb phalanx (HP:0009944)2.78037952
29Attenuation of retinal blood vessels (HP:0007843)2.76477791
30Abnormal number of erythroid precursors (HP:0012131)2.75367495
31Aplasia/hypoplasia of the humerus (HP:0006507)2.74138802
32Fused cervical vertebrae (HP:0002949)2.70983750
33Bony spicule pigmentary retinopathy (HP:0007737)2.70242650
34Medulloblastoma (HP:0002885)2.66345659
35Reticulocytopenia (HP:0001896)2.66341445
36Preauricular skin tag (HP:0000384)2.64307043
37Short humerus (HP:0005792)2.63997255
38Intestinal fistula (HP:0100819)2.59822350
39Large earlobe (HP:0009748)2.58693022
40Supernumerary spleens (HP:0009799)2.58145629
41Abnormality of the salivary glands (HP:0010286)2.57294238
42Trismus (HP:0000211)2.55858847
43Patellar aplasia (HP:0006443)2.52455231
44Hypochromic anemia (HP:0001931)2.52254668
45Abnormality of cells of the erythroid lineage (HP:0012130)2.51468748
46Partial duplication of the phalanx of hand (HP:0009999)2.48280055
47Aplasia/Hypoplasia of the patella (HP:0006498)2.47686988
48Breast hypoplasia (HP:0003187)2.47453582
49Skin tags (HP:0010609)2.45824993
50Pancreatic cysts (HP:0001737)2.42515335
51Unilateral renal agenesis (HP:0000122)2.41442276
52Volvulus (HP:0002580)2.41112333
53Bifid tongue (HP:0010297)2.39835941
54Type II lissencephaly (HP:0007260)2.37988738
55Nephronophthisis (HP:0000090)2.33818696
56Hypoplasia of the fovea (HP:0007750)2.32414016
57Aplasia/Hypoplasia of the fovea (HP:0008060)2.32414016
58Duodenal stenosis (HP:0100867)2.31889826
59Small intestinal stenosis (HP:0012848)2.31889826
60Short 5th finger (HP:0009237)2.31747021
61Vaginal fistula (HP:0004320)2.30607258
62Absent thumb (HP:0009777)2.30518534
63Renal Fanconi syndrome (HP:0001994)2.28634509
64Aplastic anemia (HP:0001915)2.27389948
65Atresia of the external auditory canal (HP:0000413)2.26549204
66Glioma (HP:0009733)2.26000123
67Myelodysplasia (HP:0002863)2.25422105
68Aplasia/Hypoplasia of the sternum (HP:0006714)2.25286076
69Abnormal rod and cone electroretinograms (HP:0008323)2.24688786
70Testicular atrophy (HP:0000029)2.24348901
71Dynein arm defect of respiratory motile cilia (HP:0012255)2.22995705
72Absent/shortened dynein arms (HP:0200106)2.22995705
73Anomalous pulmonary venous return (HP:0010772)2.21338570
74Nasal polyposis (HP:0100582)2.20471306
75Tubulointerstitial nephritis (HP:0001970)2.19692111
76Abnormality of the preputium (HP:0100587)2.15848449
77Neoplasm of the oral cavity (HP:0100649)2.15710500
78Renal duplication (HP:0000075)2.14230963
79Abnormality of the carotid arteries (HP:0005344)2.13196257
80Selective tooth agenesis (HP:0001592)2.12275472
81Pendular nystagmus (HP:0012043)2.11121861
82Amelogenesis imperfecta (HP:0000705)2.10682804
83Abnormality of the phalanges of the hallux (HP:0010057)2.10491629
84Combined immunodeficiency (HP:0005387)2.10370179
85Aplasia/Hypoplasia of the 5th finger (HP:0006262)2.09029436
86Reduced antithrombin III activity (HP:0001976)2.08218860
87Pseudobulbar signs (HP:0002200)2.07905923
88Microretrognathia (HP:0000308)2.07490344
89Supernumerary ribs (HP:0005815)2.06931136
90Abnormality of chromosome segregation (HP:0002916)2.05835939
91Ragged-red muscle fibers (HP:0003200)2.04679904
92Abnormality of chromosome stability (HP:0003220)2.04607343
93Increased serum lactate (HP:0002151)2.04200011
94Missing ribs (HP:0000921)2.04140872
95Pancreatic fibrosis (HP:0100732)2.04068480
96Duplicated collecting system (HP:0000081)2.03818824
97Aplasia/Hypoplasia of the earlobes (HP:0009906)2.02465499
98Increased CSF lactate (HP:0002490)2.02049678
99Glossoptosis (HP:0000162)2.01092180
100Amyotrophic lateral sclerosis (HP:0007354)1.99447484
101Abnormality of the renal medulla (HP:0100957)1.99310952
102Supernumerary bones of the axial skeleton (HP:0009144)1.98933712
103Acute encephalopathy (HP:0006846)1.96774349
104Horseshoe kidney (HP:0000085)1.96635746
105Acute necrotizing encephalopathy (HP:0006965)1.96183332
106Duplication of thumb phalanx (HP:0009942)1.95517331
107Renal dysplasia (HP:0000110)1.95467319
108Abnormality of the distal phalanx of the thumb (HP:0009617)1.95083123
109Increased nuchal translucency (HP:0010880)1.94923228
110Abnormality of DNA repair (HP:0003254)1.92920441
111Abnormality of the pulmonary veins (HP:0011718)1.92589999
112Abnormality of the duodenum (HP:0002246)1.92037959
113Sloping forehead (HP:0000340)1.91256826
114Abnormal pancreas size (HP:0012094)1.91158310
115Abnormal cartilage morphology (HP:0002763)1.91150279
116Abnormality of the labia minora (HP:0012880)1.90413134
117Premature ovarian failure (HP:0008209)1.90141816
118Concave nail (HP:0001598)1.89924447
119Short middle phalanx of the 5th finger (HP:0004220)1.89460960
120Abnormality of midbrain morphology (HP:0002418)1.88898998
121Molar tooth sign on MRI (HP:0002419)1.88898998
122Cerebellar dysplasia (HP:0007033)1.88554976
123Abnormal mitochondria in muscle tissue (HP:0008316)1.88042528
124Large for gestational age (HP:0001520)1.87451890
125Esophageal atresia (HP:0002032)1.87337068
126Vertebral fusion (HP:0002948)1.87298625
127Short thumb (HP:0009778)1.86801129
128Prominent nose (HP:0000448)1.86281805
129Shawl scrotum (HP:0000049)1.86085038
130Broad alveolar ridges (HP:0000187)1.84212556
131Preauricular pit (HP:0004467)1.84190522
132Periauricular skin pits (HP:0100277)1.84190522
133Ectopic kidney (HP:0000086)1.84055191
134Abnormality of the renal collecting system (HP:0004742)1.83178136
135Clubbing of toes (HP:0100760)1.82097372
136Abnormality of macular pigmentation (HP:0008002)1.81970316
137Abnormal spermatogenesis (HP:0008669)1.81744248
138Hyperkalemia (HP:0002153)1.80238804
139Increased hepatocellular lipid droplets (HP:0006565)1.79524317
140Triphalangeal thumb (HP:0001199)1.78791206
141Hypoalbuminemia (HP:0003073)1.78241747
142Abnormal albumin level (HP:0012116)1.78241747
143Cleft eyelid (HP:0000625)1.77982348
144Progressive muscle weakness (HP:0003323)1.77294425
145Absent forearm bone (HP:0003953)1.75313673
146Aplasia involving forearm bones (HP:0009822)1.75313673
147Congenital stationary night blindness (HP:0007642)1.75213830
148Abnormal protein glycosylation (HP:0012346)1.74979019
149Abnormal glycosylation (HP:0012345)1.74979019
150Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.74979019
151Abnormal protein N-linked glycosylation (HP:0012347)1.74979019
152Absent radius (HP:0003974)1.74873036
153Hypopigmentation of the fundus (HP:0007894)1.74583162
154Facial cleft (HP:0002006)1.74561371
155Abnormality of the nasal mucosa (HP:0000433)1.74381732
156Birth length less than 3rd percentile (HP:0003561)1.74190801
157Lipid accumulation in hepatocytes (HP:0006561)1.73954007
158Mitochondrial inheritance (HP:0001427)1.73598379
159Bone marrow hypocellularity (HP:0005528)1.72906401
160Tongue fasciculations (HP:0001308)1.72350242
161Type I transferrin isoform profile (HP:0003642)1.72112613
162Malignant neoplasm of the central nervous system (HP:0100836)1.71978464
163Abnormal number of incisors (HP:0011064)1.71637210
164Sclerocornea (HP:0000647)1.71578227
165Prominent occiput (HP:0000269)1.71441090
166Abnormality of small intestinal villus morphology (HP:0011472)1.71235220
167Villous atrophy (HP:0011473)1.71235220
168Optic nerve coloboma (HP:0000588)1.70890480
169Inability to walk (HP:0002540)1.70651875
170Upper limb muscle weakness (HP:0003484)1.70564214
171Bicornuate uterus (HP:0000813)1.70309782
172Generalized aminoaciduria (HP:0002909)1.70182261
173Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.68738384
174Abnormal respiratory motile cilium morphology (HP:0005938)1.68349753
175Abnormal respiratory epithelium morphology (HP:0012253)1.68349753
176Cone-rod dystrophy (HP:0000548)1.66721220
177Abnormality of alanine metabolism (HP:0010916)1.66166961
178Hyperalaninemia (HP:0003348)1.66166961
179Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.66166961
180Septate vagina (HP:0001153)1.66152177
181Abnormality of homocysteine metabolism (HP:0010919)1.66101149

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK127.78607782
2PLK45.35889629
3GRK63.67552523
4ERN13.28773753
5GRK53.28104141
6VRK23.24941745
7ZAK2.93565879
8STK102.92943974
9TTK2.72511767
10PNCK2.70428356
11CSF1R2.56439763
12BMPR1B2.48582035
13GRK12.46859021
14CDC72.38868607
15INSRR2.25271505
16ADRBK22.24172631
17STK162.22172110
18TGFBR22.18524536
19MAP4K22.11686673
20CDK72.05537584
21NME12.04746126
22TSSK62.01281681
23MAP3K102.00086300
24TAF11.90314369
25SRPK11.86087270
26WEE11.84973681
27TYRO31.82240610
28MATK1.75021827
29MAPK71.69424383
30NEK21.67049086
31WNK41.60218808
32GRK71.57245430
33NUAK11.52480444
34CHEK21.52064747
35CAMK1G1.46908534
36TESK11.46615867
37PLK11.46444866
38SMG11.45501682
39PAK41.42855752
40EPHA21.42044573
41PBK1.36673058
42EIF2AK11.34141825
43BUB11.32349851
44MOS1.26877456
45PRKD31.22473984
46CHEK11.21379180
47RPS6KB21.20353595
48STK381.19594578
49STK38L1.19496107
50CDK41.15695197
51ACVR1B1.15163313
52WNK11.13491605
53BRD41.11466325
54SIK21.09336716
55ALK1.08653479
56CAMK1D1.08046905
57EEF2K1.06740683
58DYRK31.03555624
59FGFR31.02295588
60HIPK21.00404951
61MKNK20.97346405
62IRAK30.94797520
63DYRK20.94574359
64EIF2AK30.93302259
65MKNK10.93149472
66CAMK40.92429925
67PRKG20.90571256
68MARK20.90221232
69BRSK10.88596825
70AURKB0.88084479
71MAP4K10.85598391
72MST1R0.82740701
73CSK0.78889669
74ATR0.78517681
75MAP3K90.76569525
76ITK0.75979220
77SIK30.75794959
78CDK20.75635819
79MTOR0.74739593
80BRSK20.73763951
81MUSK0.72371246
82ATM0.71071140
83EIF2AK20.70626257
84PASK0.68987260
85AKT20.68252717
86FLT30.68041559
87PIM10.67605085
88NME20.66875562
89IKBKB0.66412897
90ADRBK10.66002752
91STK30.65781826
92MAP2K20.65237348
93MAP3K80.64233856
94BRAF0.64123461
95STK40.64104044
96TRIM280.63895958
97IRAK40.62086085
98AURKA0.60509013
99PLK20.59625111
100RPS6KA40.58757304
101MAPK150.57612451
102MAP2K70.54368326
103TLK10.53674371
104PAK10.52677718
105RPS6KA10.50604884
106BLK0.50096392
107LATS20.49550029
108CDK30.49515575
109RPS6KA50.47281956
110CDK10.45467331
111MAP2K60.45386095
112MELK0.44764753
113VRK10.43610441
114PRKCI0.43047045
115TESK20.42858155
116ICK0.42106451
117CHUK0.41535238
118MAP3K70.41242163
119CSNK2A20.40923126
120CSNK2A10.40856414
121FRK0.39453573
122DDR20.38819733
123TNIK0.38436797
124CDK80.38335481
125CDK60.38023854
126JAK30.36408618
127WNK30.36177741
128RPS6KA60.35299111
129PAK20.35028591
130MAPK110.34723475
131TGFBR10.34263556
132KIT0.33551612
133CSNK1E0.32186523
134NTRK10.32038845
135GSK3B0.31997963
136NEK60.31664298
137AKT30.31219356
138MAPK10.30465759
139LATS10.29854946
140MAPK140.29134560
141PLK30.28510500
142GSK3A0.28095422
143PDGFRA0.27424006
144LRRK20.27399794
145IGF1R0.27132366
146MAPK100.25453995
147NEK10.24897413
148ZAP700.24751577
149PIM20.23394655
150YES10.23384922
151MAPKAPK20.22774742
152MST40.22210770

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030084.22338998
2DNA replication_Homo sapiens_hsa030303.61705627
3Vitamin B6 metabolism_Homo sapiens_hsa007503.25046006
4Mismatch repair_Homo sapiens_hsa034302.99344943
5Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.83054523
6Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.80654405
7RNA transport_Homo sapiens_hsa030132.69305388
8One carbon pool by folate_Homo sapiens_hsa006702.59508271
9Spliceosome_Homo sapiens_hsa030402.40670000
10Ribosome_Homo sapiens_hsa030102.38852020
11Cell cycle_Homo sapiens_hsa041102.35012704
12Fanconi anemia pathway_Homo sapiens_hsa034602.33508672
13Base excision repair_Homo sapiens_hsa034102.20015215
14Homologous recombination_Homo sapiens_hsa034402.18523701
15Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.03294032
16Fatty acid biosynthesis_Homo sapiens_hsa000611.98821962
17Oxidative phosphorylation_Homo sapiens_hsa001901.94284695
18mRNA surveillance pathway_Homo sapiens_hsa030151.94076955
19RNA polymerase_Homo sapiens_hsa030201.81281915
20Nucleotide excision repair_Homo sapiens_hsa034201.72645945
21Huntingtons disease_Homo sapiens_hsa050161.71949697
22Fructose and mannose metabolism_Homo sapiens_hsa000511.68006276
23RNA degradation_Homo sapiens_hsa030181.67526323
24Parkinsons disease_Homo sapiens_hsa050121.62806819
25Protein export_Homo sapiens_hsa030601.55839249
26Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.53039722
27Non-homologous end-joining_Homo sapiens_hsa034501.49827334
28p53 signaling pathway_Homo sapiens_hsa041151.48642906
29Basal transcription factors_Homo sapiens_hsa030221.42763562
30Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.37817610
31Pyrimidine metabolism_Homo sapiens_hsa002401.37602275
32Transcriptional misregulation in cancer_Homo sapiens_hsa052021.34146922
33Thyroid cancer_Homo sapiens_hsa052161.32883110
34Primary immunodeficiency_Homo sapiens_hsa053401.28083203
35Arachidonic acid metabolism_Homo sapiens_hsa005901.26354513
36Herpes simplex infection_Homo sapiens_hsa051681.23804556
37Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.20975372
38Galactose metabolism_Homo sapiens_hsa000521.19256584
39MicroRNAs in cancer_Homo sapiens_hsa052061.16872822
40Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.13668966
41Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.13300144
42Antigen processing and presentation_Homo sapiens_hsa046121.11462554
43Linoleic acid metabolism_Homo sapiens_hsa005911.04993334
44Butanoate metabolism_Homo sapiens_hsa006501.02924307
45Viral carcinogenesis_Homo sapiens_hsa052031.02111247
46Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.01602883
47RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.98754448
48Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.98548723
49Basal cell carcinoma_Homo sapiens_hsa052170.97489702
50NF-kappa B signaling pathway_Homo sapiens_hsa040640.96932526
51alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.95366483
52Cysteine and methionine metabolism_Homo sapiens_hsa002700.91962124
53Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.90227265
54Acute myeloid leukemia_Homo sapiens_hsa052210.89724718
55Steroid biosynthesis_Homo sapiens_hsa001000.88507121
56Olfactory transduction_Homo sapiens_hsa047400.88335688
57HTLV-I infection_Homo sapiens_hsa051660.87905076
58mTOR signaling pathway_Homo sapiens_hsa041500.85707519
59Maturity onset diabetes of the young_Homo sapiens_hsa049500.84648179
60Notch signaling pathway_Homo sapiens_hsa043300.84008664
61Alzheimers disease_Homo sapiens_hsa050100.83219874
62Small cell lung cancer_Homo sapiens_hsa052220.83108284
63Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.82945156
64Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.81752830
65T cell receptor signaling pathway_Homo sapiens_hsa046600.78403310
66Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.77194689
67Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.75724811
68Apoptosis_Homo sapiens_hsa042100.75534437
69Systemic lupus erythematosus_Homo sapiens_hsa053220.72770049
70Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.72556071
71Pathways in cancer_Homo sapiens_hsa052000.72154455
72Pentose phosphate pathway_Homo sapiens_hsa000300.72010955
73Sulfur relay system_Homo sapiens_hsa041220.70895014
74Hippo signaling pathway_Homo sapiens_hsa043900.69466291
75Metabolic pathways_Homo sapiens_hsa011000.68984171
76Selenocompound metabolism_Homo sapiens_hsa004500.67305870
77Phototransduction_Homo sapiens_hsa047440.65914164
78B cell receptor signaling pathway_Homo sapiens_hsa046620.65666169
79Epstein-Barr virus infection_Homo sapiens_hsa051690.64384637
80Hedgehog signaling pathway_Homo sapiens_hsa043400.61632219
81Pentose and glucuronate interconversions_Homo sapiens_hsa000400.61064250
82Glycosaminoglycan degradation_Homo sapiens_hsa005310.60696623
83Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.60325663
84Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.59048904
85Non-small cell lung cancer_Homo sapiens_hsa052230.58327102
86Colorectal cancer_Homo sapiens_hsa052100.58008808
87Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.56846251
88Central carbon metabolism in cancer_Homo sapiens_hsa052300.56805950
89Intestinal immune network for IgA production_Homo sapiens_hsa046720.56690549
90Regulation of actin cytoskeleton_Homo sapiens_hsa048100.56456294
91Pancreatic cancer_Homo sapiens_hsa052120.56384173
92Jak-STAT signaling pathway_Homo sapiens_hsa046300.56118508
93Measles_Homo sapiens_hsa051620.55669849
94Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.54234235
95Hematopoietic cell lineage_Homo sapiens_hsa046400.54111835
96Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.53632182
97Pyruvate metabolism_Homo sapiens_hsa006200.51831825
98Chronic myeloid leukemia_Homo sapiens_hsa052200.51211783
99N-Glycan biosynthesis_Homo sapiens_hsa005100.51202400
100Nitrogen metabolism_Homo sapiens_hsa009100.50003117
101Leukocyte transendothelial migration_Homo sapiens_hsa046700.49612667
102Folate biosynthesis_Homo sapiens_hsa007900.48908441
103TGF-beta signaling pathway_Homo sapiens_hsa043500.48472965
104Purine metabolism_Homo sapiens_hsa002300.48172729
105Thyroid hormone signaling pathway_Homo sapiens_hsa049190.47321819
106Bladder cancer_Homo sapiens_hsa052190.46972600
107Cardiac muscle contraction_Homo sapiens_hsa042600.46654323
108Proteoglycans in cancer_Homo sapiens_hsa052050.45579826
109Proteasome_Homo sapiens_hsa030500.44662852
110Wnt signaling pathway_Homo sapiens_hsa043100.44533999
111Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.43958426
112Vitamin digestion and absorption_Homo sapiens_hsa049770.43522116
113Inositol phosphate metabolism_Homo sapiens_hsa005620.43516398
114Fatty acid metabolism_Homo sapiens_hsa012120.42228649
115Legionellosis_Homo sapiens_hsa051340.41914546
116Hepatitis B_Homo sapiens_hsa051610.41399190
117Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.41033007
118Lysine degradation_Homo sapiens_hsa003100.40881200
119Influenza A_Homo sapiens_hsa051640.39325426
120Cyanoamino acid metabolism_Homo sapiens_hsa004600.39192455
121Leishmaniasis_Homo sapiens_hsa051400.38719697
122Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.37980233
123PI3K-Akt signaling pathway_Homo sapiens_hsa041510.37917044
124Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.36954607
125Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.34816858
126Adherens junction_Homo sapiens_hsa045200.34557930
127Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.33672123
128Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.33291184
129Oocyte meiosis_Homo sapiens_hsa041140.33135938
130Tryptophan metabolism_Homo sapiens_hsa003800.31126620
131Other glycan degradation_Homo sapiens_hsa005110.31031040
132Phospholipase D signaling pathway_Homo sapiens_hsa040720.30179902
133Glycerophospholipid metabolism_Homo sapiens_hsa005640.30043626
134Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.28857541
135Biosynthesis of amino acids_Homo sapiens_hsa012300.28548855
136Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.28166172
137Carbon metabolism_Homo sapiens_hsa012000.27367796
138Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.27363127
139Toxoplasmosis_Homo sapiens_hsa051450.25910458
140Glutathione metabolism_Homo sapiens_hsa004800.18733383
141Arginine and proline metabolism_Homo sapiens_hsa003300.18200278
142Fatty acid elongation_Homo sapiens_hsa000620.16340935
143Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.15996074
144Propanoate metabolism_Homo sapiens_hsa006400.12458949
145Prostate cancer_Homo sapiens_hsa052150.10839008
146Peroxisome_Homo sapiens_hsa041460.08989121
147Type II diabetes mellitus_Homo sapiens_hsa049300.07097544

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