ISL1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the LIM/homeodomain family of transcription factors. The encoded protein binds to the enhancer region of the insulin gene, among others, and may play an important role in regulating insulin gene expression. The encoded protein is central to the development of pancreatic cell lineages and may also be required for motor neuron generation. Mutations in this gene have been associated with maturity-onset diabetes of the young. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1Golgi transport vesicle coating (GO:0048200)6.45006753
2COPI coating of Golgi vesicle (GO:0048205)6.45006753
3detection of light stimulus involved in visual perception (GO:0050908)5.51255158
4detection of light stimulus involved in sensory perception (GO:0050962)5.51255158
5negative regulation of cytosolic calcium ion concentration (GO:0051481)5.03014113
6positive regulation of insulin secretion involved in cellular response to glucose stimulus (GO:003574.85904512
7endocrine pancreas development (GO:0031018)4.68408495
8retinal rod cell development (GO:0046548)4.66786115
9insulin secretion (GO:0030073)4.63440113
10positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.60564017
11cellular ketone body metabolic process (GO:0046950)4.55068093
12glandular epithelial cell differentiation (GO:0002067)4.45151228
13glycerophospholipid catabolic process (GO:0046475)4.34653261
14response to pheromone (GO:0019236)4.30362332
15regulation of glucokinase activity (GO:0033131)4.26055166
16regulation of hexokinase activity (GO:1903299)4.26055166
17peptide hormone processing (GO:0016486)4.20320179
18retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)4.19361317
19inositol phosphate catabolic process (GO:0071545)4.05213947
20* positive regulation of insulin secretion (GO:0032024)4.04541929
21ketone body metabolic process (GO:1902224)4.01249985
22auditory receptor cell differentiation (GO:0042491)3.97263307
23regulation of type B pancreatic cell apoptotic process (GO:2000674)3.90836493
24COPII vesicle coating (GO:0048208)3.83150802
25phosphorylated carbohydrate dephosphorylation (GO:0046838)3.79318958
26inositol phosphate dephosphorylation (GO:0046855)3.79318958
27urinary tract smooth muscle contraction (GO:0014848)3.78461076
28toxin metabolic process (GO:0009404)3.75332810
29nitric oxide mediated signal transduction (GO:0007263)3.67386660
30negative regulation of hormone biosynthetic process (GO:0032353)3.63541119
31peptide hormone secretion (GO:0030072)3.61007470
32regulation of insulin secretion involved in cellular response to glucose stimulus (GO:0061178)3.58794885
33dendritic spine morphogenesis (GO:0060997)3.56861859
34maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.55202251
35* regulation of insulin secretion (GO:0050796)3.53406321
36mating behavior (GO:0007617)3.50434727
37synaptic vesicle exocytosis (GO:0016079)3.50406774
38peptide secretion (GO:0002790)3.49445236
39positive regulation of vesicle fusion (GO:0031340)3.46810737
40positive regulation of glycolytic process (GO:0045821)3.45370033
41water-soluble vitamin biosynthetic process (GO:0042364)3.44747050
42regulation of glucocorticoid secretion (GO:2000849)3.44168519
43potassium ion homeostasis (GO:0055075)3.42905928
44astrocyte differentiation (GO:0048708)3.40527520
45positive regulation of gastrulation (GO:2000543)3.38593693
46striatum development (GO:0021756)3.37597321
47negative regulation of execution phase of apoptosis (GO:1900118)3.37008411
48protein maturation by protein folding (GO:0022417)3.34719888
49* positive regulation of peptide hormone secretion (GO:0090277)3.32833604
50glandular epithelial cell development (GO:0002068)3.31861802
51regulation of synaptic vesicle exocytosis (GO:2000300)3.27759098
52behavioral response to ethanol (GO:0048149)3.26433669
53adult feeding behavior (GO:0008343)3.25642729
54epithelial cell fate commitment (GO:0072148)3.24852286
55regulation of vesicle fusion (GO:0031338)3.23657501
56detection of calcium ion (GO:0005513)3.22736766
57* positive regulation of peptide secretion (GO:0002793)3.20362008
58negative regulation of hormone metabolic process (GO:0032351)3.19703088
59* regulation of peptide hormone secretion (GO:0090276)3.18770265
60L-alpha-amino acid transmembrane transport (GO:1902475)3.18190058
61positive regulation of calcium ion import (GO:0090280)3.17220305
62vesicle coating (GO:0006901)3.16304300
63nodal signaling pathway (GO:0038092)3.14012146
64* regulation of peptide secretion (GO:0002791)3.12347346
65regulation of calcium ion-dependent exocytosis (GO:0017158)3.08230102
66hormone secretion (GO:0046879)3.07911045
67regulation of energy homeostasis (GO:2000505)3.06775839
68protein localization to cilium (GO:0061512)3.04431693
69respiratory chain complex IV assembly (GO:0008535)3.03222859
70protein retention in ER lumen (GO:0006621)3.01974663
71cellular response to glucagon stimulus (GO:0071377)3.01022645
72ER overload response (GO:0006983)3.00455527
73norepinephrine metabolic process (GO:0042415)3.00227852
74neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)3.00059022
75glycine transport (GO:0015816)2.99555830
76erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)2.98734732
77L-phenylalanine catabolic process (GO:0006559)2.98734732
78succinate metabolic process (GO:0006105)2.98155421
79photoreceptor cell development (GO:0042461)2.98102307
80growth hormone secretion (GO:0030252)2.97837649
81auditory behavior (GO:0031223)2.97586904
82peristalsis (GO:0030432)2.95343789
83cytochrome complex assembly (GO:0017004)2.94776746
84axoneme assembly (GO:0035082)2.94299262
85eating behavior (GO:0042755)2.93660493
86polyol catabolic process (GO:0046174)2.93289181
87cellular potassium ion homeostasis (GO:0030007)2.93278472
88eye photoreceptor cell development (GO:0042462)2.92448769
89positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.91109492
90* neuron fate specification (GO:0048665)2.89085878
91hormone transport (GO:0009914)2.88768253
92intra-Golgi vesicle-mediated transport (GO:0006891)2.88630486
93reflex (GO:0060004)2.88292251
94macroautophagy (GO:0016236)2.87976046
95positive regulation of neurotransmitter transport (GO:0051590)2.87300972
96sequestering of metal ion (GO:0051238)2.86759479
97zinc ion homeostasis (GO:0055069)2.86040917
98preassembly of GPI anchor in ER membrane (GO:0016254)2.84933891
99regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022352.84863514
100calcium ion import (GO:0070509)2.84457249
101axon cargo transport (GO:0008088)2.84382023
102nitric oxide biosynthetic process (GO:0006809)2.83868353
103negative regulation of JUN kinase activity (GO:0043508)2.83541348
104brain morphogenesis (GO:0048854)2.83360880
105regulation of neurotransmitter uptake (GO:0051580)2.81191440
106* regulation of hormone secretion (GO:0046883)2.80774308
107phenylpropanoid metabolic process (GO:0009698)2.79682122
108positive regulation of synapse maturation (GO:0090129)2.79586078
109signal peptide processing (GO:0006465)2.78573051
110dentate gyrus development (GO:0021542)2.78340902
111cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.78259505
112positive regulation of gluconeogenesis (GO:0045722)2.77191321
113anterograde axon cargo transport (GO:0008089)2.76844962
114synaptic vesicle maturation (GO:0016188)2.76477776
115relaxation of smooth muscle (GO:0044557)2.75473793
116pteridine-containing compound biosynthetic process (GO:0042559)2.74768112
117positive regulation of amino acid transport (GO:0051957)2.74409807
118regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.73950689
119exocrine pancreas development (GO:0031017)2.73843968
120nonmotile primary cilium assembly (GO:0035058)2.73713896
121erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)2.73460923
122L-phenylalanine metabolic process (GO:0006558)2.73460923
123startle response (GO:0001964)2.73386870
124membrane repolarization during cardiac muscle cell action potential (GO:0086013)2.73275927
125intraciliary transport (GO:0042073)2.72418972
126positive regulation of potassium ion transport (GO:0043268)2.72167039
127catecholamine transport (GO:0051937)2.72149743
128type B pancreatic cell development (GO:0003323)2.72142388
129neurofilament cytoskeleton organization (GO:0060052)2.72031607
130regulation of corticosteroid hormone secretion (GO:2000846)2.71645527
131peptide transport (GO:0015833)2.71279701
132cornea development in camera-type eye (GO:0061303)2.71147633
133negative regulation of neurological system process (GO:0031645)2.71040519
134lactate metabolic process (GO:0006089)2.70018181
135response to dietary excess (GO:0002021)2.69821845
136negative regulation of phosphoprotein phosphatase activity (GO:0032515)2.69503493
137positive regulation of TOR signaling (GO:0032008)2.68489271
138regulation of dopamine uptake involved in synaptic transmission (GO:0051584)2.67667588
139regulation of catecholamine uptake involved in synaptic transmission (GO:0051940)2.67667588
140positive regulation of histone H3-K4 methylation (GO:0051571)2.67374503
141regulation of short-term neuronal synaptic plasticity (GO:0048172)2.66859324
142negative regulation of catecholamine secretion (GO:0033604)2.66826987
143regulation of synaptic vesicle transport (GO:1902803)2.66697090
144G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.66180289
145chemosensory behavior (GO:0007635)2.66086310
146cell migration in hindbrain (GO:0021535)2.65587513
147protein complex biogenesis (GO:0070271)2.65551324
148synaptic vesicle transport (GO:0048489)2.64007270
149establishment of synaptic vesicle localization (GO:0097480)2.64007270
150C-terminal protein lipidation (GO:0006501)2.63421815
151* positive regulation of hormone secretion (GO:0046887)2.62927063
152dopamine metabolic process (GO:0042417)2.62499499
153kidney morphogenesis (GO:0060993)2.59915626
154protein prenylation (GO:0018342)2.59912720
155prenylation (GO:0097354)2.59912720
156regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.59450523
157behavioral response to nicotine (GO:0035095)2.57970500
158negative regulation of gluconeogenesis (GO:0045721)2.53972787
159C-terminal protein amino acid modification (GO:0018410)2.53807652
160positive regulation of meiosis (GO:0045836)2.53152816
161regulation of vacuole organization (GO:0044088)2.52300288
162protein polyglutamylation (GO:0018095)2.51259739
163RNA destabilization (GO:0050779)2.51243787
164regulation of respiratory system process (GO:0044065)2.49974414
165neurotransmitter-gated ion channel clustering (GO:0072578)2.47229472
166magnesium ion transport (GO:0015693)2.46205000
167righting reflex (GO:0060013)2.44581406
168somite rostral/caudal axis specification (GO:0032525)2.43935615
169S-adenosylmethionine metabolic process (GO:0046500)2.40655878
170mitochondrial respiratory chain complex assembly (GO:0033108)2.39201191
171positive regulation of response to extracellular stimulus (GO:0032106)2.38927370
172positive regulation of response to nutrient levels (GO:0032109)2.38927370

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse4.87408379
2GBX2_23144817_ChIP-Seq_PC3_Human3.10142092
3DMRT1_21621532_ChIP-ChIP_FETAL_Ovary2.97292738
4REST_21632747_ChIP-Seq_MESCs_Mouse2.56362161
5GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.45932144
6IGF1R_20145208_ChIP-Seq_DFB_Human2.36454434
7PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.35034867
8REST_18959480_ChIP-ChIP_MESCs_Mouse2.21198453
9* BMI1_23680149_ChIP-Seq_NPCS_Mouse2.21073382
10* EZH2_27294783_Chip-Seq_ESCs_Mouse2.20134391
11* JARID2_20075857_ChIP-Seq_MESCs_Mouse2.14353916
12* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.11379741
13* EZH2_27304074_Chip-Seq_ESCs_Mouse2.07512035
14* SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.05044472
15ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.98346417
16* GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.96779274
17OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.93801487
18CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.92289902
19SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.90303474
20* NR3C1_23031785_ChIP-Seq_PC12_Mouse1.86274681
21* SUZ12_27294783_Chip-Seq_ESCs_Mouse1.86064438
22CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.84966494
23PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.84160723
24* FUS_26573619_Chip-Seq_HEK293_Human1.83360998
25HTT_18923047_ChIP-ChIP_STHdh_Human1.78278320
26POU3F2_20337985_ChIP-ChIP_501MEL_Human1.71894111
27CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.71150234
28FLI1_27457419_Chip-Seq_LIVER_Mouse1.69428751
29NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.68791238
30VDR_22108803_ChIP-Seq_LS180_Human1.68447422
31* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.65762410
32* JARID2_20064375_ChIP-Seq_MESCs_Mouse1.65269133
33* RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.64624049
34* CTBP2_25329375_ChIP-Seq_LNCAP_Human1.61917674
35CDX2_19796622_ChIP-Seq_MESCs_Mouse1.61486190
36PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.60638408
37* RNF2_27304074_Chip-Seq_ESCs_Mouse1.60278702
38* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.60042164
39NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.59563081
40DROSHA_22980978_ChIP-Seq_HELA_Human1.59072022
41SMAD4_21799915_ChIP-Seq_A2780_Human1.58373703
42HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.58118405
43SALL1_21062744_ChIP-ChIP_HESCs_Human1.53529249
44* PIAS1_25552417_ChIP-Seq_VCAP_Human1.51007516
45* SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.50139842
46CTBP1_25329375_ChIP-Seq_LNCAP_Human1.49007542
47* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.48663536
48STAT3_23295773_ChIP-Seq_U87_Human1.47772139
49* ZFP57_27257070_Chip-Seq_ESCs_Mouse1.47617757
50* BCAT_22108803_ChIP-Seq_LS180_Human1.47063319
51E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.46268212
52* RNF2_27304074_Chip-Seq_NSC_Mouse1.45810139
53EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.45147467
54* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.44698151
55ER_23166858_ChIP-Seq_MCF-7_Human1.44409027
56* SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.39321409
57EED_16625203_ChIP-ChIP_MESCs_Mouse1.36952329
58EZH2_18974828_ChIP-Seq_MESCs_Mouse1.36098495
59RNF2_18974828_ChIP-Seq_MESCs_Mouse1.36098495
60REST_19997604_ChIP-ChIP_NEURONS_Mouse1.35087641
61EWS_26573619_Chip-Seq_HEK293_Human1.34817100
62CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.32923382
63P53_22127205_ChIP-Seq_FIBROBLAST_Human1.30510516
64PCGF2_27294783_Chip-Seq_ESCs_Mouse1.29291644
65SOX2_21211035_ChIP-Seq_LN229_Gbm1.29142736
66* RARB_27405468_Chip-Seq_BRAIN_Mouse1.29075102
67SUZ12_27294783_Chip-Seq_NPCs_Mouse1.28487595
68* P300_19829295_ChIP-Seq_ESCs_Human1.26050165
69ZNF274_21170338_ChIP-Seq_K562_Hela1.25906947
70HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.25634102
71PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.25555600
72* ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.25033023
73P53_22387025_ChIP-Seq_ESCs_Mouse1.22002063
74STAT3_18555785_Chip-Seq_ESCs_Mouse1.21428924
75NFE2_27457419_Chip-Seq_LIVER_Mouse1.21120089
76TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.18736034
77* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.17393118
78SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.17174105
79CDX2_22108803_ChIP-Seq_LS180_Human1.16107805
80IKZF1_21737484_ChIP-ChIP_HCT116_Human1.15916942
81EZH2_27294783_Chip-Seq_NPCs_Mouse1.15693514
82NR3C1_21868756_ChIP-Seq_MCF10A_Human1.15330063
83SUZ12_18555785_Chip-Seq_ESCs_Mouse1.15053690
84ZNF217_24962896_ChIP-Seq_MCF-7_Human1.14929269
85YAP1_20516196_ChIP-Seq_MESCs_Mouse1.14866141
86KLF5_20875108_ChIP-Seq_MESCs_Mouse1.14695854
87* TOP2B_26459242_ChIP-Seq_MCF-7_Human1.14556275
88* TCF4_22108803_ChIP-Seq_LS180_Human1.13752645
89TAL1_26923725_Chip-Seq_HPCs_Mouse1.12893884
90TCF4_23295773_ChIP-Seq_U87_Human1.12102816
91FOXA1_27270436_Chip-Seq_PROSTATE_Human1.11402108
92FOXA1_25329375_ChIP-Seq_VCAP_Human1.11402108
93NANOG_19829295_ChIP-Seq_ESCs_Human1.11204210
94SOX2_19829295_ChIP-Seq_ESCs_Human1.11204210
95AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.10502285
96LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.10235391
97SMAD3_21741376_ChIP-Seq_ESCs_Human1.10151580
98SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.09791629
99SMAD3_21741376_ChIP-Seq_EPCs_Human1.09305719
100DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.08675631
101CTCF_18555785_Chip-Seq_ESCs_Mouse1.08221999
102E2F1_18555785_Chip-Seq_ESCs_Mouse1.08214287
103EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.08033914
104* AR_19668381_ChIP-Seq_PC3_Human1.07920462
105EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.06966650
106NANOG_18555785_Chip-Seq_ESCs_Mouse1.06624989
107TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.06598458
108MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.06120569
109ETV2_25802403_ChIP-Seq_MESCs_Mouse1.05773877
110* CBX2_27304074_Chip-Seq_ESCs_Mouse1.05761967
111* PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.05414604
112SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.04542389
113NCOR_22424771_ChIP-Seq_293T_Human1.04035998
114* AR_25329375_ChIP-Seq_VCAP_Human1.03275105
115ARNT_22903824_ChIP-Seq_MCF-7_Human1.03093919
116TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.03058970
117RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.02904984
118SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.02501494
119TBL1_22424771_ChIP-Seq_293T_Human1.01398488
120FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.01221756
121GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.01129160
122P300_18555785_Chip-Seq_ESCs_Mouse1.01114700
123NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse1.00985666
124* FLI1_21867929_ChIP-Seq_TH2_Mouse1.00807189
125OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.99670219
126* SMAD4_21741376_ChIP-Seq_EPCs_Human0.99374291
127BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.97469479
128RUNX2_22187159_ChIP-Seq_PCA_Human0.97046938
129EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.95936249
130TAF15_26573619_Chip-Seq_HEK293_Human0.95872700
131* FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.94962827
132* RING1B_27294783_Chip-Seq_ESCs_Mouse0.94813611
133* WT1_25993318_ChIP-Seq_PODOCYTE_Human0.94284351
134* SMAD4_21741376_ChIP-Seq_HESCs_Human0.93361367
135FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.93285235
136IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.91492322
137CBP_20019798_ChIP-Seq_JUKART_Human0.91492322
138EZH2_22144423_ChIP-Seq_EOC_Human0.91084769
139TP53_22573176_ChIP-Seq_HFKS_Human0.90728118
140NMYC_18555785_Chip-Seq_ESCs_Mouse0.89320522
141ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.87955366
142EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.87751205
143ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.87583882
144* RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.86943202
145SOX2_18555785_Chip-Seq_ESCs_Mouse0.86927087
146TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.86463249
147CMYC_18555785_Chip-Seq_ESCs_Mouse0.85243545

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010386_abnormal_urinary_bladder3.98040317
2MP0000013_abnormal_adipose_tissue3.84699808
3MP0003183_abnormal_peptide_metabolism3.61940427
4MP0002638_abnormal_pupillary_reflex3.39872740
5MP0002909_abnormal_adrenal_gland3.27464837
6MP0005551_abnormal_eye_electrophysiolog3.08477168
7MP0006292_abnormal_olfactory_placode3.04995093
8* MP0006072_abnormal_retinal_apoptosis3.03871942
9MP0005645_abnormal_hypothalamus_physiol2.65525513
10MP0004043_abnormal_pH_regulation2.62186568
11MP0008877_abnormal_DNA_methylation2.55149482
12MP0010234_abnormal_vibrissa_follicle2.54055856
13MP0005379_endocrine/exocrine_gland_phen2.44999642
14MP0001502_abnormal_circadian_rhythm2.41332696
15MP0003122_maternal_imprinting2.38734003
16MP0002693_abnormal_pancreas_physiology2.37406821
17MP0004270_analgesia2.35399706
18* MP0001944_abnormal_pancreas_morphology2.31148119
19MP0003195_calcinosis2.25082740
20MP0002090_abnormal_vision2.20917114
21MP0009780_abnormal_chondrocyte_physiolo2.19452864
22MP0002877_abnormal_melanocyte_morpholog2.12514093
23MP0009046_muscle_twitch2.12401576
24MP0001984_abnormal_olfaction2.11514172
25MP0002822_catalepsy2.06661059
26MP0000003_abnormal_adipose_tissue2.04142990
27MP0000569_abnormal_digit_pigmentation2.02173667
28MP0002734_abnormal_mechanical_nocicepti1.93574212
29* MP0005253_abnormal_eye_physiology1.89516972
30MP0000678_abnormal_parathyroid_gland1.82139312
31MP0001986_abnormal_taste_sensitivity1.80925093
32MP0002837_dystrophic_cardiac_calcinosis1.78643372
33MP0008789_abnormal_olfactory_epithelium1.78297036
34MP0003879_abnormal_hair_cell1.77015139
35MP0003283_abnormal_digestive_organ1.73812150
36MP0005646_abnormal_pituitary_gland1.67225532
37MP0001188_hyperpigmentation1.61804321
38MP0001529_abnormal_vocalization1.56886419
39MP0003011_delayed_dark_adaptation1.55782308
40* MP0002184_abnormal_innervation1.53171759
41MP0002139_abnormal_hepatobiliary_system1.52358012
42MP0002078_abnormal_glucose_homeostasis1.48780066
43MP0004019_abnormal_vitamin_homeostasis1.46871400
44MP0002102_abnormal_ear_morphology1.46518037
45* MP0005220_abnormal_exocrine_pancreas1.46182050
46* MP0000631_abnormal_neuroendocrine_gland1.45325988
47MP0004233_abnormal_muscle_weight1.44732772
48MP0009745_abnormal_behavioral_response1.44419967
49MP0002234_abnormal_pharynx_morphology1.43872601
50MP0006276_abnormal_autonomic_nervous1.42562998
51MP0005499_abnormal_olfactory_system1.42414239
52MP0005394_taste/olfaction_phenotype1.42414239
53* MP0002751_abnormal_autonomic_nervous1.40769844
54MP0003880_abnormal_central_pattern1.40046138
55MP0003959_abnormal_lean_body1.38862240
56MP0010329_abnormal_lipoprotein_level1.38222591
57MP0005448_abnormal_energy_balance1.36620062
58MP0002163_abnormal_gland_morphology1.35407734
59MP0005332_abnormal_amino_acid1.33874343
60MP0002254_reproductive_system_inflammat1.33759960
61MP0002733_abnormal_thermal_nociception1.31760358
62MP0005257_abnormal_intraocular_pressure1.27831086
63MP0002272_abnormal_nervous_system1.27031559
64MP0000427_abnormal_hair_cycle1.26790813
65MP0003890_abnormal_embryonic-extraembry1.26049056
66MP0000516_abnormal_urinary_system1.24841490
67MP0005367_renal/urinary_system_phenotyp1.24841490
68MP0003787_abnormal_imprinting1.22166573
69MP0001346_abnormal_lacrimal_gland1.21111557
70MP0001501_abnormal_sleep_pattern1.19830945
71MP0001970_abnormal_pain_threshold1.16950905
72MP0002735_abnormal_chemical_nociception1.15954386
73MP0004264_abnormal_extraembryonic_tissu1.13793863
74MP0001270_distended_abdomen1.13714526
75MP0002876_abnormal_thyroid_physiology1.12335397
76MP0006036_abnormal_mitochondrial_physio1.09908592
77MP0004782_abnormal_surfactant_physiolog1.09847064
78MP0010030_abnormal_orbit_morphology1.08736186
79MP0002938_white_spotting1.08637477
80MP0000639_abnormal_adrenal_gland1.08619262
81MP0003121_genomic_imprinting1.07852821
82MP0003635_abnormal_synaptic_transmissio1.07244313
83MP0001756_abnormal_urination1.06823416
84MP0002557_abnormal_social/conspecific_i1.04722334
85MP0005248_abnormal_Harderian_gland1.04250882
86MP0010678_abnormal_skin_adnexa1.03587781
87MP0004885_abnormal_endolymph1.03219689
88MP0000613_abnormal_salivary_gland1.02962853
89MP0003953_abnormal_hormone_level1.02072879
90MP0005636_abnormal_mineral_homeostasis1.01798496
91MP0003633_abnormal_nervous_system1.00925316
92MP0004215_abnormal_myocardial_fiber1.00450853
93MP0008961_abnormal_basal_metabolism1.00294838
94* MP0002229_neurodegeneration0.99043699
95MP0001905_abnormal_dopamine_level0.98428027
96MP0002067_abnormal_sensory_capabilities0.98426955
97MP0005174_abnormal_tail_pigmentation0.97357340
98MP0005365_abnormal_bile_salt0.97094223
99* MP0005195_abnormal_posterior_eye0.96107246
100MP0003868_abnormal_feces_composition0.95992265
101MP0001299_abnormal_eye_distance/0.93911358
102MP0003172_abnormal_lysosome_physiology0.93868190
103* MP0002882_abnormal_neuron_morphology0.93300034
104MP0004133_heterotaxia0.93083271
105MP0002928_abnormal_bile_duct0.92120832
106MP0005084_abnormal_gallbladder_morpholo0.92104798
107MP0002063_abnormal_learning/memory/cond0.91397354
108* MP0002752_abnormal_somatic_nervous0.90124845
109* MP0000955_abnormal_spinal_cord0.88960304
110MP0000538_abnormal_urinary_bladder0.88368578
111MP0004145_abnormal_muscle_electrophysio0.87840835
112MP0004142_abnormal_muscle_tone0.87183061
113MP0002572_abnormal_emotion/affect_behav0.87110804
114MP0003123_paternal_imprinting0.85745535
115MP0001664_abnormal_digestion0.83788575
116MP0004036_abnormal_muscle_relaxation0.82585313
117MP0002653_abnormal_ependyma_morphology0.81175091
118MP0001324_abnormal_eye_pigmentation0.80875882
119MP0002069_abnormal_eating/drinking_beha0.80679234
120MP0001765_abnormal_ion_homeostasis0.78878094
121MP0005389_reproductive_system_phenotype0.78673343
122MP0008775_abnormal_heart_ventricle0.78171417
123MP0001486_abnormal_startle_reflex0.77841515
124MP0005075_abnormal_melanosome_morpholog0.77425611
125MP0000015_abnormal_ear_pigmentation0.77098906
126MP0001485_abnormal_pinna_reflex0.76451523
127MP0004924_abnormal_behavior0.76265469
128MP0005386_behavior/neurological_phenoty0.76265469
129MP0008872_abnormal_physiological_respon0.76235201
130MP0005535_abnormal_body_temperature0.76183315
131MP0004085_abnormal_heartbeat0.76148899
132MP0004858_abnormal_nervous_system0.75666408
133MP0008569_lethality_at_weaning0.75657532
134* MP0004811_abnormal_neuron_physiology0.74546680
135MP0002064_seizures0.73998768
136MP0001968_abnormal_touch/_nociception0.72276345
137MP0000534_abnormal_ureter_morphology0.72086943
138MP0000372_irregular_coat_pigmentation0.71307715
139MP0003119_abnormal_digestive_system0.71270278
140* MP0005391_vision/eye_phenotype0.70704053

Predicted human phenotypes

RankGene SetZ-score
1Congenital stationary night blindness (HP:0007642)7.00781972
2Elevated circulating parathyroid hormone (PTH) level (HP:0003165)5.83553905
3Hyperinsulinemic hypoglycemia (HP:0000825)4.79109125
4Abnormality of calcium-phosphate metabolism (HP:0100530)4.77384675
5Hypoglycemic seizures (HP:0002173)4.72471885
6Aplasia/Hypoplasia of the fovea (HP:0008060)4.71791615
7Hypoplasia of the fovea (HP:0007750)4.71791615
8Severe visual impairment (HP:0001141)4.44168902
9Symptomatic seizures (HP:0011145)4.38027713
10Abnormality of the fovea (HP:0000493)4.21023650
11Central scotoma (HP:0000603)3.94238114
12Hypothermia (HP:0002045)3.85449819
13Hyperglycemia (HP:0003074)3.79627378
14Abnormal rod and cone electroretinograms (HP:0008323)3.78871579
15Abnormality of macular pigmentation (HP:0008002)3.76822188
16Agitation (HP:0000713)3.63418160
17Hypoglycemic coma (HP:0001325)3.52926550
18Abnormality of endocrine pancreas physiology (HP:0012093)3.18577979
19Abnormality of the pancreatic islet cells (HP:0006476)3.18577979
20Aplasia/Hypoplasia of the macula (HP:0008059)3.18301662
21Ketoacidosis (HP:0001993)3.17170241
22Double outlet right ventricle (HP:0001719)3.12601030
23Congenital malformation of the right heart (HP:0011723)3.12601030
24Pancreatic islet-cell hyperplasia (HP:0004510)3.04963389
25Pheochromocytoma (HP:0002666)2.99476088
26Aplasia/Hypoplasia affecting the retina (HP:0008061)2.98106845
27Insulin-resistant diabetes mellitus (HP:0000831)2.95616165
28Large for gestational age (HP:0001520)2.93192282
29Retinal atrophy (HP:0001105)2.89418457
30EEG with generalized epileptiform discharges (HP:0011198)2.85713589
31Osteomalacia (HP:0002749)2.84271512
32Late onset (HP:0003584)2.82289658
33Decreased circulating renin level (HP:0003351)2.81752619
34Abnormality of vitamin B metabolism (HP:0004340)2.79763784
35Decreased central vision (HP:0007663)2.75025280
36Growth hormone excess (HP:0000845)2.71568188
37Epileptiform EEG discharges (HP:0011182)2.70136651
38Increased circulating renin level (HP:0000848)2.69836370
39Progressive macrocephaly (HP:0004481)2.69789764
40Neuroendocrine neoplasm (HP:0100634)2.68720307
41Abnormal pancreas size (HP:0012094)2.68294814
42Hypomagnesemia (HP:0002917)2.64924303
43Ketosis (HP:0001946)2.62598563
44Hyperparathyroidism (HP:0000843)2.60977918
45Menstrual irregularities (HP:0000858)2.57088388
46Enlarged penis (HP:0000040)2.57001434
47Congenital sensorineural hearing impairment (HP:0008527)2.56601676
48Dysautonomia (HP:0002459)2.53969055
49Acute necrotizing encephalopathy (HP:0006965)2.51300095
50Nephronophthisis (HP:0000090)2.49043428
51Hypsarrhythmia (HP:0002521)2.45029414
52Severe muscular hypotonia (HP:0006829)2.43599407
53Bony spicule pigmentary retinopathy (HP:0007737)2.41516988
54Abnormal drinking behavior (HP:0030082)2.39438557
55Polydipsia (HP:0001959)2.39438557
56Orthostatic hypotension (HP:0001278)2.34491135
57Methylmalonic acidemia (HP:0002912)2.33867595
58Hypokalemia (HP:0002900)2.33352939
59Abnormality of urine glucose concentration (HP:0011016)2.32475857
60Glycosuria (HP:0003076)2.32475857
61Abnormality of the renal cortex (HP:0011035)2.28064942
62Renal cortical cysts (HP:0000803)2.26925182
63Absent rod-and cone-mediated responses on ERG (HP:0007688)2.25708481
64Gaze-evoked nystagmus (HP:0000640)2.25411578
65Scotoma (HP:0000575)2.25394111
66Sex reversal (HP:0012245)2.25167436
67Abnormal sex determination (HP:0012244)2.25167436
68Genital tract atresia (HP:0001827)2.24556336
69Polyphagia (HP:0002591)2.22072512
70Septo-optic dysplasia (HP:0100842)2.21919329
71Aqueductal stenosis (HP:0002410)2.21718280
72Bifid tongue (HP:0010297)2.20228985
73Neoplasm of the heart (HP:0100544)2.20039359
74Hypokinesia (HP:0002375)2.18627966
75Hyperventilation (HP:0002883)2.14961949
76Mitochondrial inheritance (HP:0001427)2.14950874
77Abnormality of vitamin metabolism (HP:0100508)2.14836193
78Muscular hypotonia of the trunk (HP:0008936)2.14329930
79Hyperkalemia (HP:0002153)2.12931959
80Abnormality of potassium homeostasis (HP:0011042)2.11070614
81Hamartoma of the eye (HP:0010568)2.10915111
82Type II diabetes mellitus (HP:0005978)2.10576283
83Prominent metopic ridge (HP:0005487)2.09854263
84Aplasia/hypoplasia of the uterus (HP:0008684)2.09755612
85Optic nerve hypoplasia (HP:0000609)2.08318137
86Vaginal atresia (HP:0000148)2.08307633
87Abnormal mitochondria in muscle tissue (HP:0008316)2.07509027
88Abnormal autonomic nervous system physiology (HP:0012332)2.06777687
89Intention tremor (HP:0002080)2.05805773
90Hypercortisolism (HP:0001578)2.04468724
91Medial flaring of the eyebrow (HP:0010747)2.03613581
92Abnormality of the renal medulla (HP:0100957)2.02593527
93Testicular neoplasm (HP:0010788)2.02464321
94Methylmalonic aciduria (HP:0012120)2.02291546
95Gait imbalance (HP:0002141)2.01727819
96Abnormality of magnesium homeostasis (HP:0004921)2.00359386
97Hemiparesis (HP:0001269)1.98675684
98Increased CSF lactate (HP:0002490)1.98640768
99Hyperphosphatemia (HP:0002905)1.98353391
100Prolonged QT interval (HP:0001657)1.98307648
101Acute encephalopathy (HP:0006846)1.97986867
102Increased corneal curvature (HP:0100692)1.97626164
103Keratoconus (HP:0000563)1.97626164
104Long toe (HP:0010511)1.97325994
105Dysostosis multiplex (HP:0000943)1.97079297
106Retinal dysplasia (HP:0007973)1.95750482
107Progressive neurologic deterioration (HP:0002344)1.94990731
108Congenital primary aphakia (HP:0007707)1.94930049
109Mask-like facies (HP:0000298)1.94648157
110Aplasia/Hypoplasia of the lens (HP:0008063)1.93845424
111Furrowed tongue (HP:0000221)1.92511534
112Depression (HP:0000716)1.92361216
113Abnormality of midbrain morphology (HP:0002418)1.91551362
114Molar tooth sign on MRI (HP:0002419)1.91551362
115Anxiety (HP:0000739)1.91269924
116Postural tremor (HP:0002174)1.90406820
117Poor coordination (HP:0002370)1.89370396
118Restlessness (HP:0000711)1.88346874
119Visual hallucinations (HP:0002367)1.88297996
120Atelectasis (HP:0100750)1.87983326
121Intestinal atresia (HP:0011100)1.87470884
122Abnormality of aromatic amino acid family metabolism (HP:0004338)1.87432515
123Unilateral renal agenesis (HP:0000122)1.86464406
124Progressive cerebellar ataxia (HP:0002073)1.86414834
125Poor suck (HP:0002033)1.86390912
126Congenital glaucoma (HP:0001087)1.86281134
127Abnormality of the metopic suture (HP:0005556)1.86137284
128Hypotension (HP:0002615)1.83551277
129Hypoplastic labia majora (HP:0000059)1.83136212
130Labial hypoplasia (HP:0000066)1.83107752
131Diminished movement (HP:0002374)1.82436142
132Hepatic necrosis (HP:0002605)1.81558746
133Attenuation of retinal blood vessels (HP:0007843)1.80854005
134Abnormality of renal resorption (HP:0011038)1.80781901
135Dialeptic seizures (HP:0011146)1.80759609
136Hypoalbuminemia (HP:0003073)1.80630446
137Abnormal albumin level (HP:0012116)1.80630446
138Increased hepatocellular lipid droplets (HP:0006565)1.79839401
139Nephrogenic diabetes insipidus (HP:0009806)1.79613991
140Papillary thyroid carcinoma (HP:0002895)1.79325056
141Cerebellar dysplasia (HP:0007033)1.78182443
142Occipital encephalocele (HP:0002085)1.77863425
143Amblyopia (HP:0000646)1.77478933
144Abnormality of renin-angiotensin system (HP:0000847)1.77342218
145Febrile seizures (HP:0002373)1.76056729
146True hermaphroditism (HP:0010459)1.75728158
147Type II lissencephaly (HP:0007260)1.75407286
148Anteriorly placed anus (HP:0001545)1.74002054
149Epileptic encephalopathy (HP:0200134)1.73752582
150Urinary glycosaminoglycan excretion (HP:0003541)1.73365214
151Mucopolysacchariduria (HP:0008155)1.73365214
152Absence seizures (HP:0002121)1.73167749
153Pancreatic fibrosis (HP:0100732)1.73141263
154Pancreatic cysts (HP:0001737)1.72642369

Predicted kinase interactions (KEA)

RankGene SetZ-score
1WNK36.29211149
2MAPK155.61881351
3INSRR4.40790497
4PIK3CG3.03267696
5FGFR22.81129555
6MAP3K22.59804910
7MAP4K22.51121638
8WNK42.46519669
9HIPK22.42321141
10MST42.40989221
11PRKD32.37985429
12ADRBK22.31026984
13PASK2.26430800
14NTRK32.22881888
15DAPK22.15791652
16UHMK12.09479827
17AKT31.99764946
18GRK11.92817240
19MAP2K61.92609460
20NTRK11.86515945
21EPHA31.81272157
22OXSR11.81025048
23PAK31.69853471
24NLK1.67217803
25FRK1.58993859
26MAP3K41.57221401
27TRIM281.51328157
28FER1.47303479
29MINK11.46170954
30FGFR31.44135649
31SIK31.41533796
32CSNK1G11.37446291
33PAK61.36051404
34TNIK1.34143528
35MARK11.33385398
36TAOK31.32080631
37NME11.28664649
38SGK2231.24680375
39SGK4941.24680375
40BRAF1.22825067
41CAMKK21.22476287
42ERBB31.22426801
43RIPK11.22238954
44STK391.22043327
45CDC42BPA1.20786135
46IRAK11.19668734
47TRPM71.18816334
48DYRK1B1.16187814
49IRAK21.13245975
50MAP3K91.03223739
51SCYL21.00929370
52DYRK1A0.99520278
53SGK20.99271485
54KSR20.96606626
55BCR0.95432562
56CSNK1G30.94329003
57MAP3K10.93841338
58WNK10.92950623
59CSNK1G20.89982280
60BRD40.89895689
61BMPR1B0.89277157
62GRK50.88615594
63PTK20.85945341
64STK30.85737532
65MAP2K20.85222637
66ACVR1B0.85099140
67PTK2B0.84972779
68PRKAA20.84361225
69PHKG10.83297898
70PHKG20.83297898
71ZAK0.83230797
72CAMK2D0.81883229
73RPS6KA20.81002995
74EIF2AK30.80259986
75PLK20.76708414
76PNCK0.72972458
77DYRK20.72182256
78STK110.71677340
79TLK10.71604035
80MAP2K10.68370619
81PRKCE0.67638989
82RET0.59797154
83MAPK130.58803777
84CSNK1A1L0.58197174
85ARAF0.57611859
86EPHB10.57419377
87PRKAA10.56790142
88NUAK10.55398332
89GRK70.55181191
90TESK10.55159578
91LIMK10.54971188
92MAP2K70.54788231
93CDK80.54725552
94KSR10.54335867
95MARK20.54110369
96CDK50.53399820
97FLT30.52739789
98ERN10.51796242
99CAMK2A0.51744126
100BRSK20.48660545
101CDK30.48633600
102PRKCG0.45732868
103VRK10.43991560
104MKNK20.43966800
105RAF10.43082474
106PRKCH0.43000168
107NEK10.42190896
108PRKACB0.41836509
109PLK30.41035745
110TNK20.40848114
111PRPF4B0.40527399
112PRKG10.38566521
113STK240.37866189
114ADRBK10.37743924
115AKT20.37715275
116BMPR20.37403923
117TAOK10.36427690
118CASK0.36042856
119PRKACA0.35609830
120BRSK10.35580442
121SGK30.34721854
122CDK190.34543250
123CSNK1D0.34278057
124RPS6KA50.33275029
125STK160.33273761
126PTK60.33181460
127PRKG20.33075161
128MAPK100.32718217
129PRKD20.31824961
130YES10.31304454
131CAMK10.30337148
132RPS6KA30.30060889
133RPS6KB10.29684295
134CAMKK10.28941883
135PRKCB0.28657837
136MAP2K40.28380096
137ATM0.28013443
138PRKCZ0.27595975
139STK38L0.27538009
140PRKCI0.26929801
141OBSCN0.26471844
142CDK140.25828811
143PRKCA0.25739010
144CSNK1E0.25418564
145EPHA20.24853634
146GSK3B0.24836799
147CSNK1A10.23961664
148PINK10.23769786

Predicted pathways (KEGG)

RankGene SetZ-score
1Maturity onset diabetes of the young_Homo sapiens_hsa049507.10840728
2Protein export_Homo sapiens_hsa030603.67983019
3Insulin secretion_Homo sapiens_hsa049113.55953684
4Butanoate metabolism_Homo sapiens_hsa006503.28314531
5Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.83191228
6Synaptic vesicle cycle_Homo sapiens_hsa047212.76147172
7Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.49387339
8Circadian rhythm_Homo sapiens_hsa047102.34982095
9GABAergic synapse_Homo sapiens_hsa047272.34343769
10Protein processing in endoplasmic reticulum_Homo sapiens_hsa041412.04273360
11Vibrio cholerae infection_Homo sapiens_hsa051101.99717906
12Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.99075926
13Type II diabetes mellitus_Homo sapiens_hsa049301.94671021
14Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.84076464
15Morphine addiction_Homo sapiens_hsa050321.78950093
16Selenocompound metabolism_Homo sapiens_hsa004501.78622907
17Circadian entrainment_Homo sapiens_hsa047131.70234164
18Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.66284123
19Cocaine addiction_Homo sapiens_hsa050301.65033216
20Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.62459195
21Dopaminergic synapse_Homo sapiens_hsa047281.57898060
22Type I diabetes mellitus_Homo sapiens_hsa049401.55350704
23Cholinergic synapse_Homo sapiens_hsa047251.52538640
24Serotonergic synapse_Homo sapiens_hsa047261.52376807
25Sulfur metabolism_Homo sapiens_hsa009201.50593710
26Taste transduction_Homo sapiens_hsa047421.49945549
27Nicotine addiction_Homo sapiens_hsa050331.49563480
28Ether lipid metabolism_Homo sapiens_hsa005651.48275833
29Collecting duct acid secretion_Homo sapiens_hsa049661.44955843
30Carbohydrate digestion and absorption_Homo sapiens_hsa049731.44836239
31N-Glycan biosynthesis_Homo sapiens_hsa005101.41030602
32Amphetamine addiction_Homo sapiens_hsa050311.38683176
33Regulation of autophagy_Homo sapiens_hsa041401.34259089
34Phototransduction_Homo sapiens_hsa047441.32678434
35SNARE interactions in vesicular transport_Homo sapiens_hsa041301.30048901
36Tryptophan metabolism_Homo sapiens_hsa003801.29128857
37Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.28398621
38Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.23271267
39Vitamin B6 metabolism_Homo sapiens_hsa007501.20940905
40Renin secretion_Homo sapiens_hsa049241.18663387
41Propanoate metabolism_Homo sapiens_hsa006401.17477241
42beta-Alanine metabolism_Homo sapiens_hsa004101.16811322
43Fatty acid elongation_Homo sapiens_hsa000621.15055420
44Aldosterone synthesis and secretion_Homo sapiens_hsa049251.14720838
45Peroxisome_Homo sapiens_hsa041461.13410068
46Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.08027067
47Glucagon signaling pathway_Homo sapiens_hsa049221.07689455
48Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.01197214
49Pancreatic secretion_Homo sapiens_hsa049721.00892216
50Glycosaminoglycan degradation_Homo sapiens_hsa005310.99607248
51Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.98458722
52Olfactory transduction_Homo sapiens_hsa047400.97207088
53Lysosome_Homo sapiens_hsa041420.94517463
54Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.88566993
55Vascular smooth muscle contraction_Homo sapiens_hsa042700.88007683
56Alcoholism_Homo sapiens_hsa050340.87467272
57Glutamatergic synapse_Homo sapiens_hsa047240.86229555
58Primary bile acid biosynthesis_Homo sapiens_hsa001200.85848785
59Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.84788529
60Thyroid hormone synthesis_Homo sapiens_hsa049180.82454062
61Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.81656682
62Fructose and mannose metabolism_Homo sapiens_hsa000510.80735709
63Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.80706759
64Galactose metabolism_Homo sapiens_hsa000520.80333952
65cGMP-PKG signaling pathway_Homo sapiens_hsa040220.79593553
66Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.78809658
67Pentose and glucuronate interconversions_Homo sapiens_hsa000400.77449958
68Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.75581808
69Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.74591687
70Non-homologous end-joining_Homo sapiens_hsa034500.74041570
71Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.73763146
72Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.72915417
73Inositol phosphate metabolism_Homo sapiens_hsa005620.71993230
74Oxytocin signaling pathway_Homo sapiens_hsa049210.71134131
75Linoleic acid metabolism_Homo sapiens_hsa005910.70738071
76Prolactin signaling pathway_Homo sapiens_hsa049170.70276899
77Cardiac muscle contraction_Homo sapiens_hsa042600.69960869
78cAMP signaling pathway_Homo sapiens_hsa040240.69938579
79GnRH signaling pathway_Homo sapiens_hsa049120.69220620
80Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.68932969
81Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.68588364
82Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.64889912
83Insulin signaling pathway_Homo sapiens_hsa049100.64731494
84Huntingtons disease_Homo sapiens_hsa050160.64301625
85Phosphatidylinositol signaling system_Homo sapiens_hsa040700.62806711
86Gap junction_Homo sapiens_hsa045400.62469210
87Metabolic pathways_Homo sapiens_hsa011000.61826947
88Retinol metabolism_Homo sapiens_hsa008300.60070702
89Nitrogen metabolism_Homo sapiens_hsa009100.59142956
90Prion diseases_Homo sapiens_hsa050200.58899744
91Long-term potentiation_Homo sapiens_hsa047200.58536776
92Glutathione metabolism_Homo sapiens_hsa004800.58356157
93Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.58013255
94alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.57654837
95Estrogen signaling pathway_Homo sapiens_hsa049150.57526061
96Salivary secretion_Homo sapiens_hsa049700.56814006
97Long-term depression_Homo sapiens_hsa047300.55590320
98ABC transporters_Homo sapiens_hsa020100.55543895
99mTOR signaling pathway_Homo sapiens_hsa041500.54780724
100Fatty acid metabolism_Homo sapiens_hsa012120.54395306
101Basal transcription factors_Homo sapiens_hsa030220.53967347
102Oxidative phosphorylation_Homo sapiens_hsa001900.53275467
103Fatty acid degradation_Homo sapiens_hsa000710.53046012
104RNA degradation_Homo sapiens_hsa030180.52213145
105Arginine biosynthesis_Homo sapiens_hsa002200.50062244
106Chemical carcinogenesis_Homo sapiens_hsa052040.48550397
107Glycerophospholipid metabolism_Homo sapiens_hsa005640.48380201
108Dorso-ventral axis formation_Homo sapiens_hsa043200.47954696
109Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.47493864
110Central carbon metabolism in cancer_Homo sapiens_hsa052300.45693286
111Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.45550241
112Sphingolipid metabolism_Homo sapiens_hsa006000.44848338
113Folate biosynthesis_Homo sapiens_hsa007900.43963455
114Other glycan degradation_Homo sapiens_hsa005110.43375102
115Alzheimers disease_Homo sapiens_hsa050100.43252463
116Parkinsons disease_Homo sapiens_hsa050120.42629232
117Gastric acid secretion_Homo sapiens_hsa049710.41707117
118Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.40925306
119Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.40788627
120Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.39831766
121Mineral absorption_Homo sapiens_hsa049780.39796505
122Dilated cardiomyopathy_Homo sapiens_hsa054140.39653130
123Thyroid hormone signaling pathway_Homo sapiens_hsa049190.39612070
124Wnt signaling pathway_Homo sapiens_hsa043100.38334707
125Steroid hormone biosynthesis_Homo sapiens_hsa001400.37377829
126Renal cell carcinoma_Homo sapiens_hsa052110.37025312
127Tyrosine metabolism_Homo sapiens_hsa003500.36727798
128Melanogenesis_Homo sapiens_hsa049160.36229059
129Endometrial cancer_Homo sapiens_hsa052130.36134874
130Ovarian steroidogenesis_Homo sapiens_hsa049130.35258045
131Caffeine metabolism_Homo sapiens_hsa002320.34982550
132Calcium signaling pathway_Homo sapiens_hsa040200.34632694
133AMPK signaling pathway_Homo sapiens_hsa041520.34370363
134Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.33658636
135Thyroid cancer_Homo sapiens_hsa052160.33227027
136One carbon pool by folate_Homo sapiens_hsa006700.32645165
137Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.32366755
138Arachidonic acid metabolism_Homo sapiens_hsa005900.31313507
139Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.30886775
140ErbB signaling pathway_Homo sapiens_hsa040120.30477174
141Protein digestion and absorption_Homo sapiens_hsa049740.30347775
142Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.29811601
143Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.29759877
144Longevity regulating pathway - mammal_Homo sapiens_hsa042110.29636948
145Insulin resistance_Homo sapiens_hsa049310.29173983

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