ISLR2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1pyrimidine nucleobase catabolic process (GO:0006208)8.07726981
2layer formation in cerebral cortex (GO:0021819)6.90291283
3nucleobase catabolic process (GO:0046113)6.46063255
4behavioral response to nicotine (GO:0035095)6.41908899
5cell migration in hindbrain (GO:0021535)6.18243412
6synaptic vesicle maturation (GO:0016188)5.58656103
7central nervous system projection neuron axonogenesis (GO:0021952)5.37160134
8locomotory exploration behavior (GO:0035641)5.26574722
9axonal fasciculation (GO:0007413)5.01664821
10regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act5.00708471
11neuron cell-cell adhesion (GO:0007158)4.98245372
12positive regulation of synapse maturation (GO:0090129)4.95148100
13dendrite morphogenesis (GO:0048813)4.93204243
14dendritic spine morphogenesis (GO:0060997)4.90780565
15protein localization to synapse (GO:0035418)4.86384166
16positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.78123592
17neuron recognition (GO:0008038)4.76015183
18regulation of short-term neuronal synaptic plasticity (GO:0048172)4.73474071
19retinal ganglion cell axon guidance (GO:0031290)4.63791279
20proline transport (GO:0015824)4.56237820
21vocalization behavior (GO:0071625)4.55956741
22positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.48910962
23exploration behavior (GO:0035640)4.45160996
24regulation of glutamate receptor signaling pathway (GO:1900449)4.42334701
25mitochondrion transport along microtubule (GO:0047497)4.33564780
26establishment of mitochondrion localization, microtubule-mediated (GO:0034643)4.33564780
27protein polyglutamylation (GO:0018095)4.32453201
28axon extension (GO:0048675)4.30083766
29central nervous system neuron axonogenesis (GO:0021955)4.11565429
30axon extension involved in axon guidance (GO:0048846)4.09595390
31neuron projection extension involved in neuron projection guidance (GO:1902284)4.09595390
32regulation of synapse structural plasticity (GO:0051823)4.08685709
33establishment of mitochondrion localization (GO:0051654)4.04171231
34transmission of nerve impulse (GO:0019226)4.04081584
35positive regulation of dendritic spine morphogenesis (GO:0061003)3.93451473
36postsynaptic membrane organization (GO:0001941)3.92258210
37negative regulation of axon guidance (GO:1902668)3.92026310
38response to pheromone (GO:0019236)3.89066202
39clathrin coat assembly (GO:0048268)3.86003689
40neuron projection extension (GO:1990138)3.84468375
41presynaptic membrane assembly (GO:0097105)3.81998713
42synaptic vesicle exocytosis (GO:0016079)3.79709826
43regulation of synaptic vesicle exocytosis (GO:2000300)3.79199096
44glutamate secretion (GO:0014047)3.76856723
45cerebellum development (GO:0021549)3.73888298
46hippocampus development (GO:0021766)3.73640379
47olfactory bulb development (GO:0021772)3.73506457
48cerebellar Purkinje cell layer development (GO:0021680)3.71112170
49cerebral cortex radially oriented cell migration (GO:0021799)3.68999396
50synaptic vesicle docking involved in exocytosis (GO:0016081)3.68164068
51regulation of synapse maturation (GO:0090128)3.65833469
52regulation of dendritic spine morphogenesis (GO:0061001)3.64496060
53cerebral cortex neuron differentiation (GO:0021895)3.64026541
54negative regulation of microtubule polymerization (GO:0031115)3.62655320
55cerebellar Purkinje cell differentiation (GO:0021702)3.61441120
56epithelial cilium movement (GO:0003351)3.57969168
57synaptic transmission, cholinergic (GO:0007271)3.55183128
58presynaptic membrane organization (GO:0097090)3.54792444
59glial cell proliferation (GO:0014009)3.54249323
60cerebellar granule cell differentiation (GO:0021707)3.53415829
61axonemal dynein complex assembly (GO:0070286)3.53072885
62neurotransmitter-gated ion channel clustering (GO:0072578)3.48786564
63ionotropic glutamate receptor signaling pathway (GO:0035235)3.47295601
64regulation of neuronal synaptic plasticity (GO:0048168)3.46454101
65neurofilament cytoskeleton organization (GO:0060052)3.46367196
66establishment of nucleus localization (GO:0040023)3.42360289
67positive regulation of gastrulation (GO:2000543)3.39668761
68cell proliferation in forebrain (GO:0021846)3.39582994
69mechanosensory behavior (GO:0007638)3.39279718
70neuromuscular synaptic transmission (GO:0007274)3.38780484
71nerve growth factor signaling pathway (GO:0038180)3.32911765
72negative regulation of catenin import into nucleus (GO:0035414)3.32774239
73positive regulation of filopodium assembly (GO:0051491)3.32105192
74cilium movement (GO:0003341)3.31597710
75neuron migration (GO:0001764)3.31140147
76adult walking behavior (GO:0007628)3.30076284
77calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)3.28854531
78positive regulation of dendritic spine development (GO:0060999)3.27463500
79regulation of long-term neuronal synaptic plasticity (GO:0048169)3.27420838
80negative regulation of axon extension involved in axon guidance (GO:0048843)3.27090314
81regulation of synaptic vesicle transport (GO:1902803)3.27043019
82membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.26296723
83cranial nerve morphogenesis (GO:0021602)3.25386005
84epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.24223590
85auditory behavior (GO:0031223)3.20169868
86synaptic transmission, glutamatergic (GO:0035249)3.19226843
87ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway (GO:0043163.19109679
88regulation of microtubule-based movement (GO:0060632)3.18743476
89negative regulation of axonogenesis (GO:0050771)3.18268052
90* regulation of axon extension (GO:0030516)3.17901259
91nonmotile primary cilium assembly (GO:0035058)3.15888489
92negative regulation of axon extension (GO:0030517)3.15743039
93dopamine receptor signaling pathway (GO:0007212)3.15223666
94neuromuscular process controlling balance (GO:0050885)3.14816340
95positive regulation of mitochondrial fission (GO:0090141)3.12595706
96neurotransmitter secretion (GO:0007269)3.11428517
97calcium ion-dependent exocytosis (GO:0017156)3.07684782
98dendritic spine organization (GO:0097061)3.05625941
99regulation of axon guidance (GO:1902667)3.04981606
100* positive regulation of axon extension (GO:0045773)3.02760606
101neuron projection morphogenesis (GO:0048812)3.01911429
102acrosome reaction (GO:0007340)3.00937131
103G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.99411540
104organelle transport along microtubule (GO:0072384)2.98697673
105regulation of dendritic spine development (GO:0060998)2.97776357
106sperm motility (GO:0030317)2.97666898
107membrane depolarization during action potential (GO:0086010)2.94646509
108intraciliary transport (GO:0042073)2.93906425
109regulation of neuron migration (GO:2001222)2.91712059
110regulation of collateral sprouting (GO:0048670)2.91504239
111glutamate receptor signaling pathway (GO:0007215)2.90750681
112ganglion development (GO:0061548)2.90319199
113regulation of NFAT protein import into nucleus (GO:0051532)2.88726742
114protein localization to cilium (GO:0061512)2.87698705
115* regulation of extent of cell growth (GO:0061387)2.87051155
116detection of temperature stimulus involved in sensory perception (GO:0050961)2.86105609
117detection of temperature stimulus involved in sensory perception of pain (GO:0050965)2.86105609
118response to auditory stimulus (GO:0010996)2.86038293
119synaptic vesicle endocytosis (GO:0048488)2.85436789
120axonogenesis (GO:0007409)2.84673045
121regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.83432765
122spinal cord development (GO:0021510)2.83103310
123positive regulation of dendrite morphogenesis (GO:0050775)2.83095558
124regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.81900146
125short-term memory (GO:0007614)2.81032015
126developmental cell growth (GO:0048588)2.80988556
127positive regulation of membrane potential (GO:0045838)2.80548507
128innervation (GO:0060384)2.79990148
129negative regulation of amino acid transport (GO:0051956)2.78565948
130synapse assembly (GO:0007416)2.77620093
131neuronal ion channel clustering (GO:0045161)2.77007686
132spinal cord association neuron differentiation (GO:0021527)2.76894372
133regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.76859885
134dendrite development (GO:0016358)2.76612855
135synapse organization (GO:0050808)2.76073935
136head development (GO:0060322)2.75908174
137negative regulation of synaptic transmission, GABAergic (GO:0032229)2.75891953
138semaphorin-plexin signaling pathway (GO:0071526)2.75734725
139adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)2.75303167
140regulation of microtubule polymerization (GO:0031113)2.75295891
141regulation of cilium movement (GO:0003352)2.74768507
142cell communication by electrical coupling (GO:0010644)2.74637399
143positive regulation of synapse assembly (GO:0051965)2.73712813
144* regulation of axonogenesis (GO:0050770)2.73183674
145positive regulation of dendrite development (GO:1900006)2.72997522
146regulation of female receptivity (GO:0045924)2.72587779
147regulation of synapse organization (GO:0050807)2.72492926
148positive regulation of synaptic transmission, GABAergic (GO:0032230)2.72439051
149axoneme assembly (GO:0035082)2.71984596
150microtubule severing (GO:0051013)2.71595908
151regulation of postsynaptic membrane potential (GO:0060078)2.68223495

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.37724843
2EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse3.00937780
3NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.93642158
4JARID2_20064375_ChIP-Seq_MESCs_Mouse2.80595245
5CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.67576644
6* SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.67328822
7REST_21632747_ChIP-Seq_MESCs_Mouse2.66899646
8* EZH2_27304074_Chip-Seq_ESCs_Mouse2.64856293
9* EZH2_18974828_ChIP-Seq_MESCs_Mouse2.56761149
10* RNF2_18974828_ChIP-Seq_MESCs_Mouse2.56761149
11HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.47259420
12ZFP281_18757296_ChIP-ChIP_E14_Mouse2.44026927
13* JARID2_20075857_ChIP-Seq_MESCs_Mouse2.41247245
14* EZH2_27294783_Chip-Seq_ESCs_Mouse2.39028584
15ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.37934219
16RARB_27405468_Chip-Seq_BRAIN_Mouse2.36594187
17SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.33748579
18* RNF2_27304074_Chip-Seq_ESCs_Mouse2.29591237
19REST_18959480_ChIP-ChIP_MESCs_Mouse2.23201818
20* SUZ12_27294783_Chip-Seq_ESCs_Mouse2.21052893
21SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.19801091
22SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.19343876
23* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.16132095
24MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.11777315
25* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.06528531
26GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.06027399
27* SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.05309371
28SMAD3_22036565_ChIP-Seq_ESCs_Mouse2.03633861
29DROSHA_22980978_ChIP-Seq_HELA_Human2.03456686
30KDM2B_26808549_Chip-Seq_K562_Human2.01421845
31WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse2.00787399
32GBX2_23144817_ChIP-Seq_PC3_Human1.92501055
33* RING1B_27294783_Chip-Seq_NPCs_Mouse1.92390152
34ZFP281_27345836_Chip-Seq_ESCs_Mouse1.91440088
35EED_16625203_ChIP-ChIP_MESCs_Mouse1.87073314
36TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.83359153
37ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.77354579
38TAF15_26573619_Chip-Seq_HEK293_Human1.74144598
39* RING1B_27294783_Chip-Seq_ESCs_Mouse1.72605138
40ERG_21242973_ChIP-ChIP_JURKAT_Human1.71398527
41IKZF1_21737484_ChIP-ChIP_HCT116_Human1.70261087
42TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.65516146
43* SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.64707946
44ZFP57_27257070_Chip-Seq_ESCs_Mouse1.59722567
45RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.59555910
46STAT6_21828071_ChIP-Seq_BEAS2B_Human1.57922563
47EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.56004376
48* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.55053495
49IRF1_19129219_ChIP-ChIP_H3396_Human1.52576536
50TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.51253018
51EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.48391468
52PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.42284716
53DNAJC2_21179169_ChIP-ChIP_NT2_Human1.41338028
54* NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.40567316
55RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.38747669
56OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.37696494
57CBX2_27304074_Chip-Seq_ESCs_Mouse1.34724725
58RNF2_27304074_Chip-Seq_NSC_Mouse1.34044438
59* SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.33815324
60FUS_26573619_Chip-Seq_HEK293_Human1.31341591
61ETV2_25802403_ChIP-Seq_MESCs_Mouse1.31049284
62RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.30430161
63AR_21572438_ChIP-Seq_LNCaP_Human1.29362461
64* TP53_20018659_ChIP-ChIP_R1E_Mouse1.26788533
65WT1_25993318_ChIP-Seq_PODOCYTE_Human1.26030851
66DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.23936861
67P300_19829295_ChIP-Seq_ESCs_Human1.23572803
68VDR_22108803_ChIP-Seq_LS180_Human1.22603964
69KDM2B_26808549_Chip-Seq_DND41_Human1.21831071
70* KDM2B_26808549_Chip-Seq_JURKAT_Human1.21251534
71SMAD4_21799915_ChIP-Seq_A2780_Human1.20917363
72AR_25329375_ChIP-Seq_VCAP_Human1.15686295
73TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.15417914
74POU3F2_20337985_ChIP-ChIP_501MEL_Human1.14847462
75* SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.14204146
76KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.12658297
77SMAD3_21741376_ChIP-Seq_EPCs_Human1.12226141
78AR_19668381_ChIP-Seq_PC3_Human1.11990380
79UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.11600589
80IGF1R_20145208_ChIP-Seq_DFB_Human1.10796387
81TOP2B_26459242_ChIP-Seq_MCF-7_Human1.08979664
82ZNF274_21170338_ChIP-Seq_K562_Hela1.08653795
83CTCF_27219007_Chip-Seq_Bcells_Human1.08514870
84CTBP2_25329375_ChIP-Seq_LNCAP_Human1.07968380
85* SOX2_21211035_ChIP-Seq_LN229_Gbm1.07553836
86YAP1_20516196_ChIP-Seq_MESCs_Mouse1.06517859
87TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.06435599
88LXR_22292898_ChIP-Seq_THP-1_Human1.05173454
89P53_22127205_ChIP-Seq_FIBROBLAST_Human1.02770383
90GATA1_26923725_Chip-Seq_HPCs_Mouse1.01085130
91NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.00720770
92GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.00529989
93SMAD4_21741376_ChIP-Seq_HESCs_Human1.00197957
94PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.00192858
95MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.00151304
96STAT3_23295773_ChIP-Seq_U87_Human0.99537235
97TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.99213843
98ELK4_26923725_Chip-Seq_MESODERM_Mouse0.99208342
99CBP_20019798_ChIP-Seq_JUKART_Human0.98295070
100IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.98295070
101RUNX2_22187159_ChIP-Seq_PCA_Human0.97966303
102* TET1_21490601_ChIP-Seq_MESCs_Mouse0.96595589
103POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.95910585
104TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.95910585
105SMAD3_21741376_ChIP-Seq_ESCs_Human0.93781503
106KLF5_20875108_ChIP-Seq_MESCs_Mouse0.93050572
107TFAP2A_17053090_ChIP-ChIP_MCF-7_Human0.92917938
108TCF4_23295773_ChIP-Seq_U87_Human0.92834534
109CTBP1_25329375_ChIP-Seq_LNCAP_Human0.92293819
110ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.91503131
111WDR5_24793694_ChIP-Seq_LNCAP_Human0.91000195
112JUN_21703547_ChIP-Seq_K562_Human0.90911904
113CREB1_26743006_Chip-Seq_LNCaP_Human0.90637572
114SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.90585056
115CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.90327509
116ARNT_22903824_ChIP-Seq_MCF-7_Human0.89363837
117MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.89341124
118AHR_22903824_ChIP-Seq_MCF-7_Human0.89247571
119ISL1_27105846_Chip-Seq_CPCs_Mouse0.89220321
120KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.88832803
121ER_23166858_ChIP-Seq_MCF-7_Human0.88625156
122RBPJ_22232070_ChIP-Seq_NCS_Mouse0.88458914
123* TCF3_18347094_ChIP-ChIP_MESCs_Mouse0.87714147
124GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.87575288
125SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.87005688
126* BMI1_23680149_ChIP-Seq_NPCS_Mouse0.86974375
127HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.86778780
128SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.86345012
129P300_27058665_Chip-Seq_ZR-75-30cells_Human0.85828733
130* SOX3_22085726_ChIP-Seq_NPCs_Mouse0.85526664
131* ERA_21632823_ChIP-Seq_H3396_Human0.84951946
132EWS_26573619_Chip-Seq_HEK293_Human0.84861231
133EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.84859796
134OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.84664355
135MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.84140677
136TP53_22573176_ChIP-Seq_HFKS_Human0.83736013
137POU5F1_18347094_ChIP-ChIP_MESCs_Mouse0.83618279
138FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.82900652
139CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.82563262

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity5.74336673
2MP0004270_analgesia3.89725858
3MP0000778_abnormal_nervous_system3.76814112
4MP0003635_abnormal_synaptic_transmissio3.31896175
5MP0004858_abnormal_nervous_system3.25841188
6MP0005423_abnormal_somatic_nervous3.25486368
7MP0002063_abnormal_learning/memory/cond2.95493455
8MP0003880_abnormal_central_pattern2.73814003
9MP0002822_catalepsy2.63273766
10MP0006292_abnormal_olfactory_placode2.53116084
11MP0009780_abnormal_chondrocyte_physiolo2.50022423
12MP0002638_abnormal_pupillary_reflex2.44509312
13MP0002734_abnormal_mechanical_nocicepti2.36950271
14MP0002184_abnormal_innervation2.32814224
15MP0005394_taste/olfaction_phenotype2.27959263
16MP0005499_abnormal_olfactory_system2.27959263
17MP0002653_abnormal_ependyma_morphology2.21329747
18MP0004811_abnormal_neuron_physiology2.17923274
19MP0009745_abnormal_behavioral_response2.15725445
20MP0004885_abnormal_endolymph2.13881933
21MP0002572_abnormal_emotion/affect_behav2.09876168
22MP0002733_abnormal_thermal_nociception2.06106789
23* MP0000955_abnormal_spinal_cord1.97733395
24MP0001529_abnormal_vocalization1.95539165
25MP0002064_seizures1.94716954
26MP0000537_abnormal_urethra_morphology1.84594266
27MP0001486_abnormal_startle_reflex1.83620523
28MP0008877_abnormal_DNA_methylation1.79837559
29MP0004133_heterotaxia1.78653852
30MP0003787_abnormal_imprinting1.77623888
31MP0001348_abnormal_lacrimal_gland1.77134299
32MP0003122_maternal_imprinting1.76868527
33MP0003123_paternal_imprinting1.76531496
34MP0002557_abnormal_social/conspecific_i1.76274700
35MP0003890_abnormal_embryonic-extraembry1.71068539
36MP0001440_abnormal_grooming_behavior1.70232671
37MP0001968_abnormal_touch/_nociception1.69774357
38MP0008789_abnormal_olfactory_epithelium1.68612731
39MP0009046_muscle_twitch1.68527982
40MP0003861_abnormal_nervous_system1.64495239
41MP0000569_abnormal_digit_pigmentation1.63182870
42MP0003119_abnormal_digestive_system1.62940417
43* MP0002882_abnormal_neuron_morphology1.62017735
44MP0005551_abnormal_eye_electrophysiolog1.59701484
45MP0002909_abnormal_adrenal_gland1.59109297
46MP0002152_abnormal_brain_morphology1.58694471
47MP0003329_amyloid_beta_deposits1.57812618
48MP0002735_abnormal_chemical_nociception1.57101517
49MP0001970_abnormal_pain_threshold1.56588042
50MP0001188_hyperpigmentation1.54874691
51MP0000631_abnormal_neuroendocrine_gland1.50800924
52MP0005187_abnormal_penis_morphology1.44836235
53MP0004142_abnormal_muscle_tone1.41474621
54MP0003011_delayed_dark_adaptation1.40464177
55MP0006276_abnormal_autonomic_nervous1.39189176
56MP0005386_behavior/neurological_phenoty1.37247274
57MP0004924_abnormal_behavior1.37247274
58MP0005253_abnormal_eye_physiology1.33611729
59MP0001485_abnormal_pinna_reflex1.32939292
60MP0003938_abnormal_ear_development1.30689887
61MP0002234_abnormal_pharynx_morphology1.29163454
62MP0003121_genomic_imprinting1.28405791
63MP0008961_abnormal_basal_metabolism1.26093023
64MP0010386_abnormal_urinary_bladder1.23205307
65MP0001984_abnormal_olfaction1.23092759
66MP0002751_abnormal_autonomic_nervous1.21641026
67MP0002066_abnormal_motor_capabilities/c1.21589010
68MP0005248_abnormal_Harderian_gland1.20331695
69MP0004742_abnormal_vestibular_system1.19912189
70* MP0002067_abnormal_sensory_capabilities1.15474742
71MP0002272_abnormal_nervous_system1.13090296
72MP0008569_lethality_at_weaning1.12654755
73MP0002736_abnormal_nociception_after1.11532758
74MP0005410_abnormal_fertilization1.07613473
75MP0004145_abnormal_muscle_electrophysio1.06314111
76MP0003283_abnormal_digestive_organ1.05595050
77MP0005645_abnormal_hypothalamus_physiol1.03851141
78* MP0002752_abnormal_somatic_nervous1.01368030
79MP0000049_abnormal_middle_ear1.01098025
80* MP0002081_perinatal_lethality1.00281959
81MP0002928_abnormal_bile_duct0.99593465
82MP0002229_neurodegeneration0.98831442
83MP0001905_abnormal_dopamine_level0.94570565
84MP0003137_abnormal_impulse_conducting0.94472018
85MP0001849_ear_inflammation0.93886488
86MP0001502_abnormal_circadian_rhythm0.91287542
87MP0005076_abnormal_cell_differentiation0.90677735
88MP0003879_abnormal_hair_cell0.89719605
89MP0002069_abnormal_eating/drinking_beha0.88786084
90MP0001963_abnormal_hearing_physiology0.88593144
91MP0003698_abnormal_male_reproductive0.88061471
92MP0000534_abnormal_ureter_morphology0.88011540
93MP0003634_abnormal_glial_cell0.87663927
94MP0004130_abnormal_muscle_cell0.87468720
95MP0005084_abnormal_gallbladder_morpholo0.86546897
96MP0005377_hearing/vestibular/ear_phenot0.84737366
97MP0003878_abnormal_ear_physiology0.84737366
98MP0001293_anophthalmia0.83758701
99MP0005391_vision/eye_phenotype0.83449858
100MP0002233_abnormal_nose_morphology0.81772077
101MP0002116_abnormal_craniofacial_bone0.80831436
102MP0001986_abnormal_taste_sensitivity0.80737694
103MP0002160_abnormal_reproductive_system0.80106367
104MP0003705_abnormal_hypodermis_morpholog0.79806943
105MP0003755_abnormal_palate_morphology0.79630723
106MP0002102_abnormal_ear_morphology0.79608348
107MP0008995_early_reproductive_senescence0.77774551
108MP0004085_abnormal_heartbeat0.76571726
109MP0008872_abnormal_physiological_respon0.76020701
110MP0000678_abnormal_parathyroid_gland0.75686303
111MP0003315_abnormal_perineum_morphology0.72617601
112MP0002163_abnormal_gland_morphology0.72461977
113MP0003633_abnormal_nervous_system0.72227342
114MP0006072_abnormal_retinal_apoptosis0.72056367
115MP0001501_abnormal_sleep_pattern0.71501608
116MP0000538_abnormal_urinary_bladder0.71498278
117MP0003632_abnormal_nervous_system0.71490490
118MP0008770_decreased_survivor_rate0.71237340
119MP0003942_abnormal_urinary_system0.70490457
120MP0005083_abnormal_biliary_tract0.69190886
121MP0003935_abnormal_craniofacial_develop0.68923895
122MP0010769_abnormal_survival0.68534369
123MP0005623_abnormal_meninges_morphology0.68317781
124MP0005257_abnormal_intraocular_pressure0.67091727
125MP0003631_nervous_system_phenotype0.66748723
126MP0010770_preweaning_lethality0.65313664
127MP0002082_postnatal_lethality0.65313664
128MP0010768_mortality/aging0.64187015
129MP0002092_abnormal_eye_morphology0.62661602
130MP0005195_abnormal_posterior_eye0.60910259
131MP0003303_peritoneal_inflammation0.60444113
132MP0000026_abnormal_inner_ear0.60243661
133MP0001943_abnormal_respiration0.59800862
134MP0000428_abnormal_craniofacial_morphol0.58918305

Predicted human phenotypes

RankGene SetZ-score
1Amyotrophic lateral sclerosis (HP:0007354)4.83072309
2Hepatoblastoma (HP:0002884)4.11069571
3Myokymia (HP:0002411)3.97916909
4Abnormality of the lower motor neuron (HP:0002366)3.96460276
5Cortical dysplasia (HP:0002539)3.80777953
6Abnormality of the corticospinal tract (HP:0002492)3.64104270
7Mutism (HP:0002300)3.61714725
8Excessive salivation (HP:0003781)3.47601799
9Drooling (HP:0002307)3.47601799
10Abnormality of midbrain morphology (HP:0002418)3.46501330
11Molar tooth sign on MRI (HP:0002419)3.46501330
12Supranuclear gaze palsy (HP:0000605)3.44774969
13Gait imbalance (HP:0002141)3.43296609
14Hemiparesis (HP:0001269)3.40026686
15Nephronophthisis (HP:0000090)3.38813737
16Pancreatic fibrosis (HP:0100732)3.37123454
17Retinal dysplasia (HP:0007973)3.21680635
18Pachygyria (HP:0001302)3.13123977
19Focal seizures (HP:0007359)3.11088044
20Apathy (HP:0000741)3.07276722
21Epileptic encephalopathy (HP:0200134)3.05806869
22Limb dystonia (HP:0002451)3.05452592
23True hermaphroditism (HP:0010459)3.03123384
24Insomnia (HP:0100785)2.99843863
25Visual hallucinations (HP:0002367)2.99101008
26Hyperacusis (HP:0010780)2.98136802
27Pancreatic cysts (HP:0001737)2.98009185
28Type II lissencephaly (HP:0007260)2.96285110
29Ankle clonus (HP:0011448)2.96045753
30Inappropriate behavior (HP:0000719)2.94575938
31Amblyopia (HP:0000646)2.93000134
32Medial flaring of the eyebrow (HP:0010747)2.90603094
33Obstructive sleep apnea (HP:0002870)2.88973728
34Abnormality of the astrocytes (HP:0100707)2.87767797
35Astrocytoma (HP:0009592)2.87767797
36Atonic seizures (HP:0010819)2.87458228
37Diminished motivation (HP:0000745)2.79378525
38Chronic hepatic failure (HP:0100626)2.76834407
39Renal duplication (HP:0000075)2.76356971
40Nephrogenic diabetes insipidus (HP:0009806)2.76200208
41Elfin facies (HP:0004428)2.76113660
42Congenital primary aphakia (HP:0007707)2.75002511
43Abnormal ciliary motility (HP:0012262)2.73229051
44Atrophy/Degeneration involving motor neurons (HP:0007373)2.68640177
45Abnormality of the renal medulla (HP:0100957)2.67699410
46Termporal pattern (HP:0011008)2.62773988
47Insidious onset (HP:0003587)2.62773988
48Abnormal respiratory motile cilium physiology (HP:0012261)2.62757063
49Papilledema (HP:0001085)2.61207911
50Polymicrogyria (HP:0002126)2.61027803
51Occipital encephalocele (HP:0002085)2.60622824
52Abnormal respiratory epithelium morphology (HP:0012253)2.58408771
53Abnormal respiratory motile cilium morphology (HP:0005938)2.58408771
54Lissencephaly (HP:0001339)2.58293936
55Cerebral inclusion bodies (HP:0100314)2.57370062
56Megalencephaly (HP:0001355)2.53329342
57Hyperventilation (HP:0002883)2.50288734
58Specific learning disability (HP:0001328)2.49786428
59Overriding aorta (HP:0002623)2.49594084
60Akinesia (HP:0002304)2.49073830
61Focal motor seizures (HP:0011153)2.48203884
62Neurofibrillary tangles (HP:0002185)2.48061242
63Abnormal rod and cone electroretinograms (HP:0008323)2.48040313
64Absent rod-and cone-mediated responses on ERG (HP:0007688)2.44723681
65Polyphagia (HP:0002591)2.43099461
66Poor eye contact (HP:0000817)2.42451472
67Genetic anticipation (HP:0003743)2.40532876
68Abnormality of the aortic arch (HP:0012303)2.36701459
69Morphological abnormality of the pyramidal tract (HP:0002062)2.35435537
70Vaginal atresia (HP:0000148)2.35426651
71Bony spicule pigmentary retinopathy (HP:0007737)2.35301617
72Macroorchidism (HP:0000053)2.34677169
73Fetal akinesia sequence (HP:0001989)2.34670516
74Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.34481592
75Short 4th metacarpal (HP:0010044)2.34481592
76Cerebellar dysplasia (HP:0007033)2.33844045
77Spastic tetraplegia (HP:0002510)2.33812218
78Broad-based gait (HP:0002136)2.33627650
79Disinhibition (HP:0000734)2.33255698
80Renovascular hypertension (HP:0100817)2.31127244
81Genital tract atresia (HP:0001827)2.29649112
82Anencephaly (HP:0002323)2.29406368
83Urinary urgency (HP:0000012)2.27195321
84Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.26617535
85Cystic liver disease (HP:0006706)2.26419880
86Ependymoma (HP:0002888)2.24560564
87Tubular atrophy (HP:0000092)2.24243165
88Hypoplasia of the brainstem (HP:0002365)2.22897661
89Aplasia/Hypoplasia of the brainstem (HP:0007362)2.22897661
90Abnormal social behavior (HP:0012433)2.17793322
91Impaired social interactions (HP:0000735)2.17793322
92Progressive cerebellar ataxia (HP:0002073)2.17480385
93Sacral dimple (HP:0000960)2.17217048
94Agitation (HP:0000713)2.16709948
95Pointed chin (HP:0000307)2.16490305
96Neoplasm of the heart (HP:0100544)2.16343673
97Open mouth (HP:0000194)2.16281422
98Urinary bladder sphincter dysfunction (HP:0002839)2.14631789
99Wrist flexion contracture (HP:0001239)2.14007652
100Heterotopia (HP:0002282)2.10816904
101Absent speech (HP:0001344)2.10383192
102Impaired vibration sensation in the lower limbs (HP:0002166)2.09598997
103Tubulointerstitial abnormality (HP:0001969)2.09261498
104Dialeptic seizures (HP:0011146)2.09242480
105Spastic gait (HP:0002064)2.09123764
106Depression (HP:0000716)2.07639359
107Bilateral microphthalmos (HP:0007633)2.07048282
108Postaxial foot polydactyly (HP:0001830)2.06404533
109Aplasia/Hypoplasia of the spleen (HP:0010451)2.05037312
110Oligodactyly (hands) (HP:0001180)2.04450216
111Aplasia/Hypoplasia of the sternum (HP:0006714)2.04244791
112Congenital stationary night blindness (HP:0007642)2.04142920
113Abnormal pancreas size (HP:0012094)2.03907124
114Abnormal drinking behavior (HP:0030082)2.03904980
115Polydipsia (HP:0001959)2.03904980
116Anterior segment dysgenesis (HP:0007700)2.03234305
117Narrow forehead (HP:0000341)2.02418770
118Abnormality of salivation (HP:0100755)2.01926088
119Lymphangioma (HP:0100764)2.01377761
120Anomalous pulmonary venous return (HP:0010772)2.00708113
121Lower limb muscle weakness (HP:0007340)1.99829503
122Aqueductal stenosis (HP:0002410)1.99684122
123Sclerocornea (HP:0000647)1.99548980
124Absence seizures (HP:0002121)1.99513560
125Poor coordination (HP:0002370)1.99475340
126Sleep apnea (HP:0010535)1.99233961
127Double outlet right ventricle (HP:0001719)1.98994137
128Congenital malformation of the right heart (HP:0011723)1.98994137
129Abnormality of the labia minora (HP:0012880)1.98718809
130Degeneration of the lateral corticospinal tracts (HP:0002314)1.97760745
131Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.97760745
132Hypoplasia of the corpus callosum (HP:0002079)1.97583088
133Action tremor (HP:0002345)1.97234859
134Shallow orbits (HP:0000586)1.95159451
135Glioma (HP:0009733)1.94570179
136Subacute progressive viral hepatitis (HP:0006572)1.94543083
137Postaxial hand polydactyly (HP:0001162)1.94383777
138Tubulointerstitial nephritis (HP:0001970)1.94116490
139Hypsarrhythmia (HP:0002521)1.94079875
140Shoulder girdle muscle weakness (HP:0003547)1.92419250
141Tubulointerstitial fibrosis (HP:0005576)1.91962614
142Stereotypic behavior (HP:0000733)1.91703620
143Abnormality of binocular vision (HP:0011514)1.91694740
144Diplopia (HP:0000651)1.91694740
145Generalized hypotonia (HP:0001290)1.91071954
146EEG with generalized epileptiform discharges (HP:0011198)1.90673195
147Torticollis (HP:0000473)1.90614632
148Failure to thrive in infancy (HP:0001531)1.89439423
149Flat cornea (HP:0007720)1.89106222
150Congenital hepatic fibrosis (HP:0002612)1.88997715
151Supernumerary spleens (HP:0009799)1.88359734
152Optic nerve hypoplasia (HP:0000609)1.87426917
153Abnormality of the motor neurons (HP:0002450)1.87065678
154Abnormal neuron morphology (HP:0012757)1.87065678
155Abnormal eating behavior (HP:0100738)1.87000976
156Generalized tonic-clonic seizures (HP:0002069)1.86555143
157Poor suck (HP:0002033)1.85711898
158Anosmia (HP:0000458)1.85546558
159Exotropia (HP:0000577)1.84890100
160Epileptiform EEG discharges (HP:0011182)1.84543496
161Germ cell neoplasia (HP:0100728)1.84378866
162Intellectual disability, severe (HP:0010864)1.83921573
163Intellectual disability, profound (HP:0002187)1.82807034
164Tented upper lip vermilion (HP:0010804)1.81691540
165Sporadic (HP:0003745)1.78766063
166Inability to walk (HP:0002540)1.76879762
167Febrile seizures (HP:0002373)1.76511123

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MARK18.25196187
2MAP3K93.49519365
3DYRK22.57848480
4SIK22.57236942
5EPHA32.50044566
6MAP4K22.18069173
7TRIM282.13016400
8TYRO32.12643161
9NTRK22.11618966
10MINK12.10094335
11DYRK32.06173365
12PHKG12.06123360
13PHKG22.06123360
14MAP3K42.03644193
15NTRK32.01732836
16EPHB21.96994184
17MAPK131.93813258
18KSR11.93276187
19EPHA41.92543681
20PAK61.91620406
21LATS21.87648852
22DAPK21.80144949
23ERBB31.78225706
24EPHB11.75178515
25SGK4941.61784871
26SGK2231.61784871
27GRK51.59801390
28PINK11.56219414
29WNK41.43360784
30ICK1.41111238
31MAP2K71.38881646
32MARK21.35453046
33CSNK1G21.31032062
34CDK51.29209181
35NTRK11.28814791
36TAOK11.28095309
37CAMKK11.27909481
38MAPK151.25604994
39MAP2K41.22825377
40CDK121.17443310
41PRKD31.17269680
42UHMK11.11462337
43TRIB31.10842060
44SIK31.09755510
45FRK1.08888330
46ALK1.04580279
47KSR21.04146817
48CSNK1G31.00225461
49WNK30.96965599
50LIMK10.95113487
51INSRR0.93476239
52CSNK1A1L0.93207994
53CDK150.92835533
54PKN20.92210047
55CDK180.91958698
56MAP3K100.89785683
57SGK20.89740686
58DYRK1A0.88624929
59CAMKK20.86536111
60CDK140.86422313
61MAP3K110.86304771
62STK110.85526737
63RET0.84280830
64CDK11A0.82214146
65PRKCZ0.81607178
66DAPK10.80013864
67PDGFRA0.79643297
68PRPF4B0.78647759
69TNIK0.78153156
70PKN10.77873343
71RIPK10.76171190
72PRKCG0.75102479
73MAP3K60.73319037
74PAK30.72321156
75ERBB20.71736378
76CAMK10.71057254
77RPS6KA20.70072444
78GRK60.68307218
79BMPR1B0.67664154
80OXSR10.67470774
81MAPK120.67318948
82BCKDK0.66545484
83WNK10.65293627
84GRK10.64056098
85FGFR20.61055839
86CSNK1G10.59059294
87ADRBK10.58844216
88DDR20.58027436
89STK160.57102629
90CAMK40.56474361
91PLK20.55881491
92MAP2K60.54048080
93CASK0.51451127
94PRKACA0.50964899
95CAMK1G0.50851466
96EEF2K0.50426177
97PRKCE0.49977100
98SCYL20.49555280
99MAPK90.49023958
100FYN0.47665567
101PNCK0.47476140
102BCR0.45358311
103ILK0.45124219
104PRKG10.44792510
105NUAK10.44761991
106MATK0.42433970
107MAP3K20.40637365
108CSNK1D0.39302958
109AKT30.38970866
110PRKAA10.38894942
111TESK10.38586707
112SGK30.38155215
113PRKCI0.37586840
114CDC42BPA0.37326411
115MAPK80.36926825
116NEK20.36865643
117STK380.35738223
118RPS6KA30.34866365
119CSNK1A10.34780289
120HIPK20.34236062
121PRKCH0.33651447
122SGK10.33438596
123CDK190.33281696
124MAPK100.32134901
125PLK40.31995618
126RPS6KA50.30589068
127GSK3B0.30522496
128NEK10.30464701
129CAMK2A0.30435094
130LMTK20.30399531
131DYRK1B0.30029717
132MTOR0.29923707
133ADRBK20.29651281
134CSNK1E0.28975742
135FGR0.28806751
136RPS6KA40.28536523
137AURKA0.27267860

Predicted pathways (KEGG)

RankGene SetZ-score
1Axon guidance_Homo sapiens_hsa043602.61822791
2Nicotine addiction_Homo sapiens_hsa050332.35304949
3Phototransduction_Homo sapiens_hsa047442.29987081
4Synaptic vesicle cycle_Homo sapiens_hsa047212.23849942
5Circadian entrainment_Homo sapiens_hsa047132.16320666
6Cardiac muscle contraction_Homo sapiens_hsa042602.15352866
7Glutamatergic synapse_Homo sapiens_hsa047242.13727886
8GABAergic synapse_Homo sapiens_hsa047272.10728473
9Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.06230318
10Dopaminergic synapse_Homo sapiens_hsa047282.00996360
11Long-term potentiation_Homo sapiens_hsa047201.87770250
12Olfactory transduction_Homo sapiens_hsa047401.86284220
13Endometrial cancer_Homo sapiens_hsa052131.83116477
14Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.78755779
15Cholinergic synapse_Homo sapiens_hsa047251.76372433
16Morphine addiction_Homo sapiens_hsa050321.76371635
17Colorectal cancer_Homo sapiens_hsa052101.73739909
18Gap junction_Homo sapiens_hsa045401.70152768
19Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.65716236
20Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.62582836
21Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.59446366
22Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.55649181
23Oxidative phosphorylation_Homo sapiens_hsa001901.54845248
24Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.53424949
25Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.52754409
26Amphetamine addiction_Homo sapiens_hsa050311.52393991
27Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.50095073
28Glioma_Homo sapiens_hsa052141.49187772
29ErbB signaling pathway_Homo sapiens_hsa040121.47658394
30mTOR signaling pathway_Homo sapiens_hsa041501.45619886
31Parkinsons disease_Homo sapiens_hsa050121.43835149
32Oxytocin signaling pathway_Homo sapiens_hsa049211.43397012
33Butanoate metabolism_Homo sapiens_hsa006501.43345245
34Long-term depression_Homo sapiens_hsa047301.40329935
35Cocaine addiction_Homo sapiens_hsa050301.39651386
36Aldosterone synthesis and secretion_Homo sapiens_hsa049251.35623663
37GnRH signaling pathway_Homo sapiens_hsa049121.30479232
38Salivary secretion_Homo sapiens_hsa049701.30268233
39Estrogen signaling pathway_Homo sapiens_hsa049151.29607226
40Renin secretion_Homo sapiens_hsa049241.28215690
41Serotonergic synapse_Homo sapiens_hsa047261.26462425
42Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.26108070
43Type II diabetes mellitus_Homo sapiens_hsa049301.26067640
44Neurotrophin signaling pathway_Homo sapiens_hsa047221.25861499
45Steroid biosynthesis_Homo sapiens_hsa001001.25248803
46Insulin secretion_Homo sapiens_hsa049111.23128261
47Renal cell carcinoma_Homo sapiens_hsa052111.22580687
48Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.18281908
49VEGF signaling pathway_Homo sapiens_hsa043701.17786321
50Gastric acid secretion_Homo sapiens_hsa049711.16396920
51Huntingtons disease_Homo sapiens_hsa050161.13023017
52Basal cell carcinoma_Homo sapiens_hsa052171.10141580
53Melanogenesis_Homo sapiens_hsa049161.10136575
54Phospholipase D signaling pathway_Homo sapiens_hsa040721.10101129
55Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.09509454
56Collecting duct acid secretion_Homo sapiens_hsa049661.08300244
57Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.08289713
58Hippo signaling pathway_Homo sapiens_hsa043901.08115660
59Non-small cell lung cancer_Homo sapiens_hsa052231.07024446
60Choline metabolism in cancer_Homo sapiens_hsa052311.06597915
61Wnt signaling pathway_Homo sapiens_hsa043101.06070685
62Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.05570586
63Taste transduction_Homo sapiens_hsa047421.05403398
64Thyroid hormone signaling pathway_Homo sapiens_hsa049191.03809033
65Alzheimers disease_Homo sapiens_hsa050101.03339986
66alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.03326499
67Linoleic acid metabolism_Homo sapiens_hsa005911.02078508
68Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.00260832
69Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.99624551
70cAMP signaling pathway_Homo sapiens_hsa040240.99397535
71Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.97933003
72Oocyte meiosis_Homo sapiens_hsa041140.97501627
73Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.96956757
74Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.96803076
75Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.94587798
76Hedgehog signaling pathway_Homo sapiens_hsa043400.92319044
77Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.90308011
78Calcium signaling pathway_Homo sapiens_hsa040200.89288005
79Ovarian steroidogenesis_Homo sapiens_hsa049130.89190992
80MAPK signaling pathway_Homo sapiens_hsa040100.87105729
81Tryptophan metabolism_Homo sapiens_hsa003800.86176855
82Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.85561104
83Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.85149460
84Dorso-ventral axis formation_Homo sapiens_hsa043200.84293036
85Viral myocarditis_Homo sapiens_hsa054160.84251544
86Rap1 signaling pathway_Homo sapiens_hsa040150.83892896
87Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.83857726
88Ras signaling pathway_Homo sapiens_hsa040140.83658775
89Longevity regulating pathway - mammal_Homo sapiens_hsa042110.83414925
90cGMP-PKG signaling pathway_Homo sapiens_hsa040220.82860012
91Central carbon metabolism in cancer_Homo sapiens_hsa052300.81829499
92Sphingolipid signaling pathway_Homo sapiens_hsa040710.81540764
93Phosphatidylinositol signaling system_Homo sapiens_hsa040700.79017126
94Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.79013619
95Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.77884074
96Regulation of autophagy_Homo sapiens_hsa041400.77330128
97Ether lipid metabolism_Homo sapiens_hsa005650.76158799
98Insulin signaling pathway_Homo sapiens_hsa049100.74644508
99Alcoholism_Homo sapiens_hsa050340.73530341
100AMPK signaling pathway_Homo sapiens_hsa041520.73317068
101Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.71262076
102Pancreatic cancer_Homo sapiens_hsa052120.69493660
103Chronic myeloid leukemia_Homo sapiens_hsa052200.68834210
104Endocytosis_Homo sapiens_hsa041440.68294844
105Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.66883210
106Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.66276186
107Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.65624123
108Carbohydrate digestion and absorption_Homo sapiens_hsa049730.65354647
109Tight junction_Homo sapiens_hsa045300.65086342
110Maturity onset diabetes of the young_Homo sapiens_hsa049500.64612811
111Regulation of actin cytoskeleton_Homo sapiens_hsa048100.63633338
112Dilated cardiomyopathy_Homo sapiens_hsa054140.62725583
113Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.62028750
114Vascular smooth muscle contraction_Homo sapiens_hsa042700.60962662
115MicroRNAs in cancer_Homo sapiens_hsa052060.60834706
116Prolactin signaling pathway_Homo sapiens_hsa049170.59970596
117Propanoate metabolism_Homo sapiens_hsa006400.58085268
118mRNA surveillance pathway_Homo sapiens_hsa030150.57434565
119Notch signaling pathway_Homo sapiens_hsa043300.55666862
120Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.54173514
121Arginine and proline metabolism_Homo sapiens_hsa003300.53879480
122Fat digestion and absorption_Homo sapiens_hsa049750.53417090
123Peroxisome_Homo sapiens_hsa041460.52857104
124Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.52776556
125Thyroid hormone synthesis_Homo sapiens_hsa049180.49926725
126Sulfur relay system_Homo sapiens_hsa041220.49298467
127Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.48539170
128Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.47990428
129Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.47358629
130Bile secretion_Homo sapiens_hsa049760.47127055
131Prion diseases_Homo sapiens_hsa050200.46457702
132Proteoglycans in cancer_Homo sapiens_hsa052050.45211225
133Caffeine metabolism_Homo sapiens_hsa002320.44969823
134Pathways in cancer_Homo sapiens_hsa052000.44813888
135Fatty acid metabolism_Homo sapiens_hsa012120.44751922
136Glucagon signaling pathway_Homo sapiens_hsa049220.43976189
137Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.41608397
138Fatty acid biosynthesis_Homo sapiens_hsa000610.40585809
139Protein export_Homo sapiens_hsa030600.39989891
140beta-Alanine metabolism_Homo sapiens_hsa004100.39218432
141Pancreatic secretion_Homo sapiens_hsa049720.36257448
142Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.35312421
143Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.29315109

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