ISOC1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1L-phenylalanine catabolic process (GO:0006559)5.96169249
2erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)5.96169249
3L-phenylalanine metabolic process (GO:0006558)5.82806256
4erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)5.82806256
5alpha-linolenic acid metabolic process (GO:0036109)5.48470667
6triglyceride-rich lipoprotein particle remodeling (GO:0034370)5.45647073
7aromatic amino acid family catabolic process (GO:0009074)5.36368161
8cysteine metabolic process (GO:0006534)4.89769141
9glyoxylate metabolic process (GO:0046487)4.89394166
10complement activation, alternative pathway (GO:0006957)4.87509389
11kynurenine metabolic process (GO:0070189)4.85703447
12indolalkylamine catabolic process (GO:0046218)4.82160694
13tryptophan catabolic process (GO:0006569)4.82160694
14indole-containing compound catabolic process (GO:0042436)4.82160694
15sulfur amino acid catabolic process (GO:0000098)4.79825577
16bile acid biosynthetic process (GO:0006699)4.77241158
17urea cycle (GO:0000050)4.76363313
18urea metabolic process (GO:0019627)4.76363313
19regulation of triglyceride catabolic process (GO:0010896)4.72803824
20fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.71312374
21valine metabolic process (GO:0006573)4.69587977
22lysine catabolic process (GO:0006554)4.65501612
23lysine metabolic process (GO:0006553)4.65501612
24tryptophan metabolic process (GO:0006568)4.62307597
25protein carboxylation (GO:0018214)4.59655410
26peptidyl-glutamic acid carboxylation (GO:0017187)4.59655410
27regulation of protein activation cascade (GO:2000257)4.54583065
28homocysteine metabolic process (GO:0050667)4.46960778
29amino-acid betaine metabolic process (GO:0006577)4.35294970
30nitrogen cycle metabolic process (GO:0071941)4.33849177
31regulation of complement activation (GO:0030449)4.31859102
32high-density lipoprotein particle remodeling (GO:0034375)4.31815713
33proteasome assembly (GO:0043248)4.29816236
34CENP-A containing nucleosome assembly (GO:0034080)4.29454869
35serine family amino acid catabolic process (GO:0009071)4.27547928
36ribosome assembly (GO:0042255)4.27378959
37negative regulation of fibrinolysis (GO:0051918)4.24049531
38positive regulation of fatty acid beta-oxidation (GO:0032000)4.22488076
39chromatin remodeling at centromere (GO:0031055)4.16470019
40bile acid metabolic process (GO:0008206)4.15703584
41acylglycerol homeostasis (GO:0055090)4.08994406
42triglyceride homeostasis (GO:0070328)4.08994406
43negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)4.04308238
44regulation of fibrinolysis (GO:0051917)4.02254375
45DNA strand elongation involved in DNA replication (GO:0006271)4.01917017
46plasma lipoprotein particle clearance (GO:0034381)3.98831218
47ethanol oxidation (GO:0006069)3.96316913
48fatty acid beta-oxidation (GO:0006635)3.93141196
49glycine metabolic process (GO:0006544)3.91703283
50tyrosine metabolic process (GO:0006570)3.88475782
51regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.88265122
52establishment of integrated proviral latency (GO:0075713)3.87665976
53aromatic amino acid family metabolic process (GO:0009072)3.87170577
54DNA strand elongation (GO:0022616)3.86786840
55positive regulation of lipid catabolic process (GO:0050996)3.85867439
56reverse cholesterol transport (GO:0043691)3.85691147
572-oxoglutarate metabolic process (GO:0006103)3.85204841
58protein-lipid complex remodeling (GO:0034368)3.85119753
59macromolecular complex remodeling (GO:0034367)3.85119753
60plasma lipoprotein particle remodeling (GO:0034369)3.85119753
61phospholipid efflux (GO:0033700)3.84251922
62alpha-amino acid catabolic process (GO:1901606)3.82337953
63anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.80551217
64fatty acid oxidation (GO:0019395)3.79114254
65positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.75631238
66bile acid and bile salt transport (GO:0015721)3.74380297
67tricarboxylic acid cycle (GO:0006099)3.73845144
68cellular ketone body metabolic process (GO:0046950)3.72752732
69negative regulation of cholesterol transport (GO:0032375)3.70990900
70negative regulation of sterol transport (GO:0032372)3.70990900
71lipid oxidation (GO:0034440)3.70116324
72negative regulation of ligase activity (GO:0051352)3.65141530
73negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.65141530
74regulation of fatty acid beta-oxidation (GO:0031998)3.65036583
75purine nucleobase biosynthetic process (GO:0009113)3.63380261
76fatty acid catabolic process (GO:0009062)3.62632310
77serine family amino acid metabolic process (GO:0009069)3.58459516
78regulation of cholesterol esterification (GO:0010872)3.58170193
79regulation of cellular amino acid metabolic process (GO:0006521)3.58154200
80cellular amino acid catabolic process (GO:0009063)3.57827642
81telomere maintenance via semi-conservative replication (GO:0032201)3.55745497
82carnitine metabolic process (GO:0009437)3.55554741
83short-chain fatty acid metabolic process (GO:0046459)3.54024233
84positive regulation of fatty acid oxidation (GO:0046321)3.51907447
85monocarboxylic acid catabolic process (GO:0072329)3.51217501
86DNA replication checkpoint (GO:0000076)3.50785427
87triglyceride catabolic process (GO:0019433)3.49577988
88acetyl-CoA metabolic process (GO:0006084)3.49317589
89cellular modified amino acid catabolic process (GO:0042219)3.45577059
90phospholipid homeostasis (GO:0055091)3.43512825
91imidazole-containing compound metabolic process (GO:0052803)3.42777947
92DNA ligation (GO:0006266)3.42542841
93indolalkylamine metabolic process (GO:0006586)3.41969920
94cellular glucuronidation (GO:0052695)3.41301711
95mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.40736273
96histone exchange (GO:0043486)3.40168629
97acylglycerol catabolic process (GO:0046464)3.39745877
98neutral lipid catabolic process (GO:0046461)3.39745877
99tricarboxylic acid metabolic process (GO:0072350)3.39492744
100cullin deneddylation (GO:0010388)3.39105386
101benzene-containing compound metabolic process (GO:0042537)3.37765846
102plasma lipoprotein particle assembly (GO:0034377)3.36945720
103organic acid catabolic process (GO:0016054)3.36649747
104carboxylic acid catabolic process (GO:0046395)3.36649747
105oxaloacetate metabolic process (GO:0006107)3.35277638
106low-density lipoprotein particle clearance (GO:0034383)3.34908072
107branched-chain amino acid metabolic process (GO:0009081)3.30367437
108fatty acid transmembrane transport (GO:1902001)3.28685896
109serine family amino acid biosynthetic process (GO:0009070)3.27343782
110negative regulation of lipase activity (GO:0060192)3.27112951
111regulation of cholesterol homeostasis (GO:2000188)3.26748028
112IMP biosynthetic process (GO:0006188)3.26456333
113coenzyme catabolic process (GO:0009109)3.26040462
114lipoprotein metabolic process (GO:0042157)3.25986190
115positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.25064245
116protein deneddylation (GO:0000338)3.22685377
117cholesterol homeostasis (GO:0042632)3.22523255
118positive regulation of triglyceride metabolic process (GO:0090208)3.22256218
119regulation of sequestering of triglyceride (GO:0010889)3.22029674
120cholesterol efflux (GO:0033344)3.21984358
121glutamate metabolic process (GO:0006536)3.21805308
122DNA replication-independent nucleosome organization (GO:0034724)3.20940114
123DNA replication-independent nucleosome assembly (GO:0006336)3.20940114
124nucleobase biosynthetic process (GO:0046112)3.20892071
125biotin metabolic process (GO:0006768)3.19825585
126sterol homeostasis (GO:0055092)3.19404549
127branched-chain amino acid catabolic process (GO:0009083)3.18514855
128regulation of mitochondrial translation (GO:0070129)3.17393334
129complement activation (GO:0006956)3.16819955
130establishment of protein localization to mitochondrial membrane (GO:0090151)3.16801450
131DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.15074254
132oxidative phosphorylation (GO:0006119)3.13863676
133signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.13268494
134signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.13268494
135signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.13268494
136intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.12623413
137signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.12623413
138NADH metabolic process (GO:0006734)3.12320397
139positive regulation of ligase activity (GO:0051351)3.11738960
140telomere maintenance via recombination (GO:0000722)3.07353969
141signal transduction involved in DNA integrity checkpoint (GO:0072401)3.06756514
142signal transduction involved in DNA damage checkpoint (GO:0072422)3.06756514
143L-methionine salvage (GO:0071267)3.05576885
144L-methionine biosynthetic process (GO:0071265)3.05576885
145amino acid salvage (GO:0043102)3.05576885
146L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.04395638
147rRNA modification (GO:0000154)3.02654872
148regulation of ubiquitin-protein transferase activity (GO:0051438)3.01350087
149L-serine metabolic process (GO:0006563)3.01046783
150signal transduction involved in cell cycle checkpoint (GO:0072395)2.99568324
151tetrahydrofolate metabolic process (GO:0046653)2.97118458
152folic acid-containing compound biosynthetic process (GO:0009396)2.96787562
153DNA double-strand break processing (GO:0000729)2.93074683
154mitotic metaphase plate congression (GO:0007080)2.92600333
155mitotic recombination (GO:0006312)2.92311014
156regulation of ligase activity (GO:0051340)2.91125506
157pseudouridine synthesis (GO:0001522)2.91086500
158DNA replication-dependent nucleosome assembly (GO:0006335)2.88938634
159DNA replication-dependent nucleosome organization (GO:0034723)2.88938634
160pteridine-containing compound biosynthetic process (GO:0042559)2.84121817
161establishment of viral latency (GO:0019043)2.82821718
162regulation of cellular amine metabolic process (GO:0033238)2.81870293
163DNA catabolic process, exonucleolytic (GO:0000738)2.81631797
164G1/S transition of mitotic cell cycle (GO:0000082)2.81485460
165cell cycle G1/S phase transition (GO:0044843)2.81485460
166IMP metabolic process (GO:0046040)2.80474001
167regulation of centriole replication (GO:0046599)2.79382521
168mitotic sister chromatid segregation (GO:0000070)2.77864293
169protein localization to kinetochore (GO:0034501)2.77342190
170deoxyribonucleotide biosynthetic process (GO:0009263)2.75968703
171RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.75962320
172tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.75962320
173formation of translation preinitiation complex (GO:0001731)2.75873873
174histone mRNA metabolic process (GO:0008334)2.75180696
175somatic hypermutation of immunoglobulin genes (GO:0016446)2.73379197
176somatic diversification of immune receptors via somatic mutation (GO:0002566)2.73379197
177nucleotide-excision repair, DNA gap filling (GO:0006297)2.73179813
178viral mRNA export from host cell nucleus (GO:0046784)2.72261318
179regulation of double-strand break repair via homologous recombination (GO:0010569)2.71617175
180somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.71261587
181somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.71261587
182isotype switching (GO:0045190)2.71261587
183regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)2.68291435
184double-strand break repair via nonhomologous end joining (GO:0006303)2.66668042
185non-recombinational repair (GO:0000726)2.66668042
186DNA unwinding involved in DNA replication (GO:0006268)2.65775852
187protein targeting to mitochondrion (GO:0006626)2.65497927
188DNA damage response, detection of DNA damage (GO:0042769)2.65367580
189spliceosomal snRNP assembly (GO:0000387)2.64465585
190telomere maintenance via telomere lengthening (GO:0010833)2.62996422
191pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.62264413
192DNA replication initiation (GO:0006270)2.59929279

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse9.35810839
2PPARG_19300518_ChIP-PET_3T3-L1_Mouse6.62216971
3RXR_22158963_ChIP-Seq_LIVER_Mouse6.55328343
4PPARA_22158963_ChIP-Seq_LIVER_Mouse5.82492525
5EGR1_23403033_ChIP-Seq_LIVER_Mouse5.05663538
6LXR_22158963_ChIP-Seq_LIVER_Mouse5.04131241
7KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human5.01573219
8CEBPA_23403033_ChIP-Seq_LIVER_Mouse4.12455957
9FOXO1_23066095_ChIP-Seq_LIVER_Mouse3.60968739
10E2F4_17652178_ChIP-ChIP_JURKAT_Human3.58496276
11GABP_17652178_ChIP-ChIP_JURKAT_Human3.41457080
12CREB1_15753290_ChIP-ChIP_HEK293T_Human3.39993084
13NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.22161162
14E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.16465709
15EST1_17652178_ChIP-ChIP_JURKAT_Human3.10601513
16CEBPB_23403033_ChIP-Seq_LIVER_Mouse3.09726211
17JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.08509481
18TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse3.08443603
19NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.94912448
20E2F7_22180533_ChIP-Seq_HELA_Human2.93925510
21GATA1_22025678_ChIP-Seq_K562_Human2.84362987
22CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.71405077
23HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.68163390
24MYC_18358816_ChIP-ChIP_MESCs_Mouse2.64890180
25MYC_19030024_ChIP-ChIP_MESCs_Mouse2.63407502
26FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.62423618
27ETS1_20019798_ChIP-Seq_JURKAT_Human2.59856450
28CLOCK_20551151_ChIP-Seq_293T_Human2.57360635
29NELFA_20434984_ChIP-Seq_ESCs_Mouse2.53015489
30DCP1A_22483619_ChIP-Seq_HELA_Human2.46530257
31IRF8_22096565_ChIP-ChIP_GC-B_Human2.41522492
32FOXM1_23109430_ChIP-Seq_U2OS_Human2.35391451
33STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.34586397
34MYC_19079543_ChIP-ChIP_MESCs_Mouse2.31801002
35HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.21578584
36THAP11_20581084_ChIP-Seq_MESCs_Mouse2.19219738
37ELK1_19687146_ChIP-ChIP_HELA_Human2.16743520
38HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.13988814
39FOXP3_21729870_ChIP-Seq_TREG_Human2.12716024
40VDR_23849224_ChIP-Seq_CD4+_Human2.12437121
41PADI4_21655091_ChIP-ChIP_MCF-7_Human2.09750082
42SRF_21415370_ChIP-Seq_HL-1_Mouse2.04199476
43MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.98248186
44MYCN_18555785_ChIP-Seq_MESCs_Mouse1.97785739
45PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.97592977
46FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.96887479
47MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.93644075
48GABP_19822575_ChIP-Seq_HepG2_Human1.87997933
49IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.80731840
50HOXB4_20404135_ChIP-ChIP_EML_Mouse1.80685561
51XRN2_22483619_ChIP-Seq_HELA_Human1.74844390
52TTF2_22483619_ChIP-Seq_HELA_Human1.74797412
53ZNF263_19887448_ChIP-Seq_K562_Human1.74158123
54KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.73503755
55TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.71587304
56EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.69800789
57STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.69255929
58ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.68053558
59YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.61919198
60NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.59084174
61POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.57485098
62TP63_17297297_ChIP-ChIP_HaCaT_Human1.47714157
63POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.40851445
64EGR1_19374776_ChIP-ChIP_THP-1_Human1.36897840
65MYC_18940864_ChIP-ChIP_HL60_Human1.36080439
66NANOG_18555785_ChIP-Seq_MESCs_Mouse1.35620191
67MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.32664329
68TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.31134463
69AR_21909140_ChIP-Seq_LNCAP_Human1.30911159
70SALL1_21062744_ChIP-ChIP_HESCs_Human1.22249679
71ESR1_15608294_ChIP-ChIP_MCF-7_Human1.21688334
72NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.20064745
73E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.18738085
74SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.17190457
75SOX2_27498859_Chip-Seq_STOMACH_Mouse1.16062651
76KDM5A_27292631_Chip-Seq_BREAST_Human1.15099301
77CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.14794628
78FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.14498770
79BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.12293233
80FOXA2_19822575_ChIP-Seq_HepG2_Human1.11639237
81NANOG_16153702_ChIP-ChIP_HESCs_Human1.11105158
82* HNF4A_19822575_ChIP-Seq_HepG2_Human1.09954019
83ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.07148295
84ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.07035464
85NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.06575426
86CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.06347529
87CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.05992438
88GATA4_25053715_ChIP-Seq_YYC3_Human1.05759984
89YY1_21170310_ChIP-Seq_MESCs_Mouse1.04871788
90ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.02661108
91SOX17_20123909_ChIP-Seq_XEN_Mouse1.01957885
92MYB_21317192_ChIP-Seq_ERMYB_Mouse1.01876581
93MYC_22102868_ChIP-Seq_BL_Human1.00811975
94VDR_22108803_ChIP-Seq_LS180_Human1.00364429
95FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.99749750
96IRF1_19129219_ChIP-ChIP_H3396_Human0.99021778
97STAT3_1855785_ChIP-Seq_MESCs_Mouse0.98342054
98CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.97754577
99BRD4_27068464_Chip-Seq_AML-cells_Mouse0.96579890
100TFEB_21752829_ChIP-Seq_HELA_Human0.94790194
101RARG_19884340_ChIP-ChIP_MEFs_Mouse0.93139650
102RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.92647819
103HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.91559081
104EWS_26573619_Chip-Seq_HEK293_Human0.91520724
105KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.91134324
106SCL_19346495_ChIP-Seq_HPC-7_Human0.90512790
107ZFX_18555785_ChIP-Seq_MESCs_Mouse0.88772517
108NOTCH1_21737748_ChIP-Seq_TLL_Human0.88256948
109MYC_18555785_ChIP-Seq_MESCs_Mouse0.87469847
110GATA6_25053715_ChIP-Seq_YYC3_Human0.87232545
111TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.83823920
112SALL4_18804426_ChIP-ChIP_XEN_Mouse0.83629150
113ELF1_17652178_ChIP-ChIP_JURKAT_Human0.82907595
114RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.80620006
115IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.78517765
116* KLF4_18555785_ChIP-Seq_MESCs_Mouse0.76503544
117HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.76435426
118CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.75686449
119POU5F1_16153702_ChIP-ChIP_HESCs_Human0.75670717
120CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.75299440
121TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.75129305
122POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.75103081
123SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.74170085
124* ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.74146314
125SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse0.73828202
126* GATA2_22383799_ChIP-Seq_G1ME_Mouse0.73815243
127* GATA1_22383799_ChIP-Seq_G1ME_Mouse0.73667212
128ELF5_23300383_ChIP-Seq_T47D_Human0.73262284
129SOX2_18555785_ChIP-Seq_MESCs_Mouse0.72529096
130CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.72520292
131TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.72207928
132SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.72152184
133AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.71930901
134FLI1_27457419_Chip-Seq_LIVER_Mouse0.71543971
135RXRA_24833708_ChIP-Seq_LIVER_Mouse0.71167083
136* FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.70430386
137PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.70011818
138BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.69809577
139ERG_20887958_ChIP-Seq_HPC-7_Mouse0.69631290
140FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.69005615
141PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.68905048
142SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.68699531
143Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.68409967
144PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.68041040
145HTT_18923047_ChIP-ChIP_STHdh_Human0.67747501
146RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.67544085
147E2F1_21310950_ChIP-Seq_MCF-7_Human0.67357464
148ATF3_27146783_Chip-Seq_COLON_Human0.66907178
149FOXO3_23340844_ChIP-Seq_DLD1_Human0.66644223
150CHD1_26751641_Chip-Seq_LNCaP_Human0.65999425
151TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.65940888
152* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.65825999
153NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.64528450
154ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.64326274
155GATA1_19941826_ChIP-Seq_K562_Human0.63979449
156ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.63730150
157MAF_26560356_Chip-Seq_TH1_Human0.63245850
158MECOM_23826213_ChIP-Seq_KASUMI_Mouse0.63005230
159SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.62545808
160SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.59276918
161CEBPB_22108803_ChIP-Seq_LS180_Human0.58686263
162TCF7_22412390_ChIP-Seq_EML_Mouse0.57904443
163TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.57726454
164VDR_21846776_ChIP-Seq_THP-1_Human0.57493886
165HIF1A_21447827_ChIP-Seq_MCF-7_Human0.57385285
166PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.56885546
167PPAR_26484153_Chip-Seq_NCI-H1993_Human0.56646913
168PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.56478365
169IRF8_27001747_Chip-Seq_BMDM_Mouse0.56452111
170ESR1_21235772_ChIP-Seq_MCF-7_Human0.55453461
171KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.54422472
172GATA3_24758297_ChIP-Seq_MCF-7_Human0.54232295
173* E2F1_18555785_ChIP-Seq_MESCs_Mouse0.54081815
174ELK3_25401928_ChIP-Seq_HUVEC_Human0.54072554

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system6.79085088
2MP0005360_urolithiasis6.10659777
3MP0005365_abnormal_bile_salt5.06740716
4MP0005085_abnormal_gallbladder_physiolo5.05120146
5MP0010094_abnormal_chromosome_stability3.97540312
6MP0003693_abnormal_embryo_hatching3.79871150
7MP0008875_abnormal_xenobiotic_pharmacok3.68023890
8MP0004957_abnormal_blastocyst_morpholog3.63009005
9MP0010329_abnormal_lipoprotein_level3.28022271
10MP0003252_abnormal_bile_duct3.27806678
11MP0008058_abnormal_DNA_repair3.20526095
12MP0003806_abnormal_nucleotide_metabolis3.20101314
13MP0003111_abnormal_nucleus_morphology3.12571583
14MP0003077_abnormal_cell_cycle2.76268220
15MP0008057_abnormal_DNA_replication2.64384619
16MP0008932_abnormal_embryonic_tissue2.54539580
17MP0001666_abnormal_nutrient_absorption2.48442770
18MP0003941_abnormal_skin_development2.47983123
19MP0009840_abnormal_foam_cell2.46657172
20MP0005083_abnormal_biliary_tract2.37379452
21MP0003191_abnormal_cellular_cholesterol2.30992293
22MP0008007_abnormal_cellular_replicative2.23055138
23MP0003718_maternal_effect2.16862728
24MP0005332_abnormal_amino_acid2.10444707
25MP0000609_abnormal_liver_physiology2.10436158
26MP0005670_abnormal_white_adipose2.09571580
27MP0003195_calcinosis2.05082433
28MP0003705_abnormal_hypodermis_morpholog2.05032707
29MP0003786_premature_aging2.04689402
30MP0004215_abnormal_myocardial_fiber1.93522847
31MP0002118_abnormal_lipid_homeostasis1.90876815
32MP0006035_abnormal_mitochondrial_morpho1.81303708
33MP0001727_abnormal_embryo_implantation1.80815382
34MP0001730_embryonic_growth_arrest1.76024641
35MP0005319_abnormal_enzyme/_coenzyme1.68783273
36MP0004019_abnormal_vitamin_homeostasis1.67762854
37MP0004130_abnormal_muscle_cell1.65650540
38MP0002138_abnormal_hepatobiliary_system1.60855042
39MP0003868_abnormal_feces_composition1.55262088
40MP0005666_abnormal_adipose_tissue1.52669610
41MP0003890_abnormal_embryonic-extraembry1.49081649
42MP0005330_cardiomyopathy1.46127942
43MP0003186_abnormal_redox_activity1.44792149
44MP0002254_reproductive_system_inflammat1.42175870
45MP0003221_abnormal_cardiomyocyte_apopto1.41992892
46MP0009643_abnormal_urine_homeostasis1.38972935
47MP0000350_abnormal_cell_proliferation1.37823191
48MP0005584_abnormal_enzyme/coenzyme_acti1.37708164
49MP0010307_abnormal_tumor_latency1.37182201
50MP0001697_abnormal_embryo_size1.36648298
51MP0010234_abnormal_vibrissa_follicle1.33847394
52MP0002102_abnormal_ear_morphology1.33064977
53MP0009697_abnormal_copulation1.31412735
54MP0001672_abnormal_embryogenesis/_devel1.31192999
55MP0005380_embryogenesis_phenotype1.31192999
56MP0001764_abnormal_homeostasis1.29397693
57MP0000598_abnormal_liver_morphology1.29144475
58MP0008995_early_reproductive_senescence1.27747909
59MP0002160_abnormal_reproductive_system1.26518427
60MP0001529_abnormal_vocalization1.22551458
61MP0004185_abnormal_adipocyte_glucose1.21850733
62MP0003984_embryonic_growth_retardation1.15605945
63MP0002088_abnormal_embryonic_growth/wei1.15435914
64MP0002971_abnormal_brown_adipose1.13441927
65MP0002080_prenatal_lethality1.10520103
66MP0002822_catalepsy1.09221708
67MP0005220_abnormal_exocrine_pancreas1.08101776
68MP0000358_abnormal_cell_content/1.07940557
69MP0003123_paternal_imprinting1.06458835
70MP0005501_abnormal_skin_physiology1.05454767
71MP0009763_increased_sensitivity_to1.05149393
72MP0005334_abnormal_fat_pad1.04679230
73MP0006036_abnormal_mitochondrial_physio1.03124537
74MP0004084_abnormal_cardiac_muscle1.03040478
75MP0002876_abnormal_thyroid_physiology1.02181963
76MP0006054_spinal_hemorrhage1.01755246
77MP0003656_abnormal_erythrocyte_physiolo1.00236960
78MP0008877_abnormal_DNA_methylation0.99559853
79MP0003119_abnormal_digestive_system0.98215770
80MP0000313_abnormal_cell_death0.97269569
81MP0002078_abnormal_glucose_homeostasis0.95173671
82MP0008469_abnormal_protein_level0.95009190
83MP0010368_abnormal_lymphatic_system0.94946087
84MP0006138_congestive_heart_failure0.94934630
85MP0002090_abnormal_vision0.93915751
86MP0006072_abnormal_retinal_apoptosis0.92610298
87MP0005375_adipose_tissue_phenotype0.92446341
88MP0002166_altered_tumor_susceptibility0.92247608
89MP0009764_decreased_sensitivity_to0.90337087
90MP0001293_anophthalmia0.89982748
91MP0003137_abnormal_impulse_conducting0.89471221
92MP0003300_gastrointestinal_ulcer0.89120417
93MP0005385_cardiovascular_system_phenoty0.87879951
94MP0001544_abnormal_cardiovascular_syste0.87879951
95MP0005367_renal/urinary_system_phenotyp0.87229914
96MP0000516_abnormal_urinary_system0.87229914
97MP0001929_abnormal_gametogenesis0.86950526
98MP0005636_abnormal_mineral_homeostasis0.85789337
99MP0009053_abnormal_anal_canal0.85271930
100MP0002009_preneoplasia0.84956919
101MP0008438_abnormal_cutaneous_collagen0.84543653
102MP0002084_abnormal_developmental_patter0.84174143
103MP0009642_abnormal_blood_homeostasis0.83585035
104MP0003724_increased_susceptibility_to0.83213047
105MP0002210_abnormal_sex_determination0.82541689
106MP0002085_abnormal_embryonic_tissue0.82452660
107MP0000653_abnormal_sex_gland0.82235798
108MP0004147_increased_porphyrin_level0.82114530
109MP0002970_abnormal_white_adipose0.81950717
110MP0001145_abnormal_male_reproductive0.81742091
111MP0009115_abnormal_fat_cell0.81470758
112MP0002060_abnormal_skin_morphology0.80392917
113MP0002972_abnormal_cardiac_muscle0.79151649
114MP0003011_delayed_dark_adaptation0.76834686
115MP0005647_abnormal_sex_gland0.76639494
116MP0002019_abnormal_tumor_incidence0.74905305
117MP0000372_irregular_coat_pigmentation0.74519379
118MP0002796_impaired_skin_barrier0.74479248
119MP0004264_abnormal_extraembryonic_tissu0.74105363
120MP0008789_abnormal_olfactory_epithelium0.73796841
121MP0002127_abnormal_cardiovascular_syste0.73265420
122MP0001756_abnormal_urination0.73250609
123MP0001881_abnormal_mammary_gland0.73061055
124MP0001188_hyperpigmentation0.71826831
125MP0008872_abnormal_physiological_respon0.71492831
126MP0002086_abnormal_extraembryonic_tissu0.71451627
127MP0005464_abnormal_platelet_physiology0.71220006
128MP0009672_abnormal_birth_weight0.70877411
129MP0005275_abnormal_skin_tensile0.70735062
130MP0003315_abnormal_perineum_morphology0.69888605
131MP0005408_hypopigmentation0.69794067
132MP0001661_extended_life_span0.69275422
133MP0001853_heart_inflammation0.69112961
134MP0010352_gastrointestinal_tract_polyps0.68161545
135MP0010630_abnormal_cardiac_muscle0.67469846
136MP0005451_abnormal_body_composition0.66374248
137MP0003436_decreased_susceptibility_to0.66258217
138MP0009765_abnormal_xenobiotic_induced0.65992268
139MP0002837_dystrophic_cardiac_calcinosis0.65967567
140MP0005448_abnormal_energy_balance0.65194616
141MP0005535_abnormal_body_temperature0.64112495
142MP0004782_abnormal_surfactant_physiolog0.62977584
143MP0005376_homeostasis/metabolism_phenot0.58150073
144MP0005248_abnormal_Harderian_gland0.57938274
145MP0002136_abnormal_kidney_physiology0.57150887
146MP0003567_abnormal_fetal_cardiomyocyte0.55650057
147MP0000685_abnormal_immune_system0.54411512
148MP0004947_skin_inflammation0.54041136
149MP0003566_abnormal_cell_adhesion0.53208349
150MP0001835_abnormal_antigen_presentation0.53000646
151MP0001944_abnormal_pancreas_morphology0.52953732
152MP0005266_abnormal_metabolism0.52922025
153MP0001845_abnormal_inflammatory_respons0.51004172
154MP0009785_altered_susceptibility_to0.50579276
155MP0005058_abnormal_lysosome_morphology0.50258941
156MP0002396_abnormal_hematopoietic_system0.50245991
157MP0003959_abnormal_lean_body0.49520351
158MP0009379_abnormal_foot_pigmentation0.49308592
159MP0000427_abnormal_hair_cycle0.49192332
160MP0005187_abnormal_penis_morphology0.47726365
161MP0002006_tumorigenesis0.47272339
162MP0001243_abnormal_dermal_layer0.46860381
163MP0001216_abnormal_epidermal_layer0.45447789
164MP0001545_abnormal_hematopoietic_system0.45357571
165MP0005397_hematopoietic_system_phenotyp0.45357571
166MP0003953_abnormal_hormone_level0.44361619

Predicted human phenotypes

RankGene SetZ-score
1Intrahepatic cholestasis (HP:0001406)5.87605947
2Abnormality of aromatic amino acid family metabolism (HP:0004338)5.79477955
3Deep venous thrombosis (HP:0002625)5.70930574
4Abnormality of monocarboxylic acid metabolism (HP:0010996)5.35245791
5Xanthomatosis (HP:0000991)5.26752260
6Hypobetalipoproteinemia (HP:0003563)5.01120982
7Hypoglycemic coma (HP:0001325)4.89201559
8Prolonged partial thromboplastin time (HP:0003645)4.77212007
9Complement deficiency (HP:0004431)4.66257328
10Hyperlipoproteinemia (HP:0010980)4.66138334
11Hyperammonemia (HP:0001987)4.39625229
12Ketosis (HP:0001946)4.22851571
13Increased serum pyruvate (HP:0003542)4.16803524
14Abnormality of glycolysis (HP:0004366)4.04731449
15Hyperglycinuria (HP:0003108)4.04289312
16Epidermoid cyst (HP:0200040)4.00858134
17Hypolipoproteinemia (HP:0010981)3.98031908
18Hyperglycinemia (HP:0002154)3.93514088
19Abnormality of the common coagulation pathway (HP:0010990)3.91271322
20Abnormality of glycine metabolism (HP:0010895)3.85491628
21Abnormality of serine family amino acid metabolism (HP:0010894)3.85491628
22Abnormality of the level of lipoprotein cholesterol (HP:0010979)3.84238175
23Ketoacidosis (HP:0001993)3.68795792
24Abnormality of glutamine family amino acid metabolism (HP:0010902)3.67102361
25Hypoalphalipoproteinemia (HP:0003233)3.61864173
26Abnormality of fatty-acid metabolism (HP:0004359)3.58899780
27Joint hemorrhage (HP:0005261)3.54761884
28Abnormality of the intrinsic pathway (HP:0010989)3.51433708
29Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.47121324
30Abnormality of complement system (HP:0005339)3.41780220
31Hypercholesterolemia (HP:0003124)3.40013871
32Fat malabsorption (HP:0002630)3.37683967
33Acute encephalopathy (HP:0006846)3.34698493
34Abnormality of sulfur amino acid metabolism (HP:0004339)3.31722327
35Increased hepatocellular lipid droplets (HP:0006565)3.15736917
36Abnormality of aspartate family amino acid metabolism (HP:0010899)3.12062238
37Abnormality of pyrimidine metabolism (HP:0004353)3.05930229
38Type I transferrin isoform profile (HP:0003642)3.02543432
39Lipid accumulation in hepatocytes (HP:0006561)3.02316026
40Hyperalaninemia (HP:0003348)3.02312800
41Abnormality of pyruvate family amino acid metabolism (HP:0010915)3.02312800
42Abnormality of alanine metabolism (HP:0010916)3.02312800
43Acute necrotizing encephalopathy (HP:0006965)3.01840891
44Conjugated hyperbilirubinemia (HP:0002908)3.00456980
45Hypoglycemic seizures (HP:0002173)2.92588144
46Abnormal mitochondria in muscle tissue (HP:0008316)2.92224554
47Abnormality of methionine metabolism (HP:0010901)2.91888201
48Reduced antithrombin III activity (HP:0001976)2.90787326
49Hyperbilirubinemia (HP:0002904)2.89538864
50Abnormality of nucleobase metabolism (HP:0010932)2.85842807
51Dicarboxylic aciduria (HP:0003215)2.85315682
52Abnormality of dicarboxylic acid metabolism (HP:0010995)2.85315682
53Generalized aminoaciduria (HP:0002909)2.84115571
54Increased CSF lactate (HP:0002490)2.83967245
55Skin nodule (HP:0200036)2.82401942
56Megaloblastic anemia (HP:0001889)2.81530033
57Increased intramyocellular lipid droplets (HP:0012240)2.77322240
58Chromosomal breakage induced by crosslinking agents (HP:0003221)2.77015547
59Hepatic necrosis (HP:0002605)2.76854315
60Myocardial infarction (HP:0001658)2.76091488
61Hepatocellular carcinoma (HP:0001402)2.75891207
62Abnormality of purine metabolism (HP:0004352)2.75799096
63Mitochondrial inheritance (HP:0001427)2.70053221
64Abnormality of serum amino acid levels (HP:0003112)2.68637855
65Increased serum lactate (HP:0002151)2.63923060
66Lactic acidosis (HP:0003128)2.63845482
67Multiple enchondromatosis (HP:0005701)2.61554772
68Chromsome breakage (HP:0040012)2.61081691
69Metabolic acidosis (HP:0001942)2.60567294
70Systemic lupus erythematosus (HP:0002725)2.60334678
71Spastic diplegia (HP:0001264)2.60100402
72Microvesicular hepatic steatosis (HP:0001414)2.58988486
73Renal Fanconi syndrome (HP:0001994)2.57532483
74Delayed CNS myelination (HP:0002188)2.56775481
75Abnormal protein glycosylation (HP:0012346)2.55276298
76Abnormal glycosylation (HP:0012345)2.55276298
77Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.55276298
78Abnormal protein N-linked glycosylation (HP:0012347)2.55276298
79Late onset (HP:0003584)2.52319476
80Increased muscle lipid content (HP:0009058)2.52247244
81Palpitations (HP:0001962)2.50993373
82Abnormality of the anterior horn cell (HP:0006802)2.49920072
83Degeneration of anterior horn cells (HP:0002398)2.49920072
84Nausea (HP:0002018)2.49505816
85Neoplasm of the adrenal gland (HP:0100631)2.44281866
86Progressive macrocephaly (HP:0004481)2.39255645
87Decreased activity of mitochondrial respiratory chain (HP:0008972)2.38442364
88Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.38442364
89Hyperinsulinemic hypoglycemia (HP:0000825)2.37849425
90Birth length less than 3rd percentile (HP:0003561)2.37452357
91Steatorrhea (HP:0002570)2.35751912
92Abnormality of the preputium (HP:0100587)2.35108127
93Hyperglycemia (HP:0003074)2.34431876
94Hepatocellular necrosis (HP:0001404)2.33279975
95Abnormality of the labia minora (HP:0012880)2.33183011
96Meckel diverticulum (HP:0002245)2.31268439
97Methylmalonic acidemia (HP:0002912)2.29978906
98Abnormality of chromosome stability (HP:0003220)2.29603556
99Abnormal gallbladder physiology (HP:0012438)2.27816760
100Cholecystitis (HP:0001082)2.27816760
101Pancreatitis (HP:0001733)2.27365826
102Esophageal varix (HP:0002040)2.26590455
103Abnormal cartilage morphology (HP:0002763)2.26385090
104Hypertriglyceridemia (HP:0002155)2.21532628
105Breast carcinoma (HP:0003002)2.19529219
106Hypochromic microcytic anemia (HP:0004840)2.17383993
107Lethargy (HP:0001254)2.17119823
108Proximal tubulopathy (HP:0000114)2.15319940
109Hydroxyprolinuria (HP:0003080)2.14526393
110Abnormality of proline metabolism (HP:0010907)2.14526393
111Abnormality of the fetal cardiovascular system (HP:0010948)2.08942936
112Abnormal umbilical cord blood vessels (HP:0011403)2.08942936
113Single umbilical artery (HP:0001195)2.08942936
114Abnormality of the ileum (HP:0001549)2.08715887
115Acanthocytosis (HP:0001927)2.08019512
116Gingival bleeding (HP:0000225)2.05061745
117Neonatal onset (HP:0003623)2.04479057
118Myoglobinuria (HP:0002913)2.03375741
119Exercise intolerance (HP:0003546)2.03253339
120Aplasia/Hypoplasia of the uvula (HP:0010293)2.02122817
121Symptomatic seizures (HP:0011145)2.01751413
122Posterior subcapsular cataract (HP:0007787)2.00875083
123Thrombophlebitis (HP:0004418)2.00363607
124Glomerulonephritis (HP:0000099)1.99683795
125Ovarian neoplasm (HP:0100615)1.99080052
126Spontaneous abortion (HP:0005268)1.97941503
127Insulin resistance (HP:0000855)1.97054194
128Cerebral edema (HP:0002181)1.95772902
129Methylmalonic aciduria (HP:0012120)1.93847700
130Recurrent gram-negative bacterial infections (HP:0005420)1.93600202
131Hyperphosphaturia (HP:0003109)1.92277387
132Malnutrition (HP:0004395)1.92203502
133Hemorrhage of the eye (HP:0011885)1.90986700
134Respiratory failure (HP:0002878)1.90747824
135Gout (HP:0001997)1.89819987
136Vomiting (HP:0002013)1.89262306
137Abnormal lung lobation (HP:0002101)1.89193513
138Pancytopenia (HP:0001876)1.88137570
139Menorrhagia (HP:0000132)1.87986009
140Abnormality of the umbilical cord (HP:0010881)1.86803897
141Limb hypertonia (HP:0002509)1.85650118
142Irritability (HP:0000737)1.84770997
143Ragged-red muscle fibers (HP:0003200)1.84177254
144Thyroid carcinoma (HP:0002890)1.83983590
145Testicular atrophy (HP:0000029)1.83400484
146Elevated hepatic transaminases (HP:0002910)1.81909118
147Oligomenorrhea (HP:0000876)1.81474697
148Mitral stenosis (HP:0001718)1.80667126
149Abnormality of urine glucose concentration (HP:0011016)1.79923090
150Glycosuria (HP:0003076)1.79923090
151Abnormality of the pancreatic islet cells (HP:0006476)1.79438356
152Abnormality of endocrine pancreas physiology (HP:0012093)1.79438356
153Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.78635351
154Sensorimotor neuropathy (HP:0007141)1.78502428
155Brushfield spots (HP:0001088)1.78168073
156Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.77817354
157Abnormality of iron homeostasis (HP:0011031)1.77748398
158Hypoplastic left heart (HP:0004383)1.77511046
159Duodenal stenosis (HP:0100867)1.77324427
160Small intestinal stenosis (HP:0012848)1.77324427
161Abnormality of transition element cation homeostasis (HP:0011030)1.76115850
162Renal cortical cysts (HP:0000803)1.73455860
163Enlarged kidneys (HP:0000105)1.73304137
164Increased mean platelet volume (HP:0011877)1.72552528
165Rhabdomyolysis (HP:0003201)1.72405373
166Pancreatic islet-cell hyperplasia (HP:0004510)1.69915450
167Neonatal hypoglycemia (HP:0001998)1.69855073

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK4.55119808
2BUB14.16515730
3TRIB33.73279720
4SIK13.63184701
5EIF2AK13.62335726
6PKN23.38243868
7ERN13.30302794
8SRPK13.21135726
9FLT33.02691181
10FGFR42.92314117
11TTK2.81291152
12MST42.78078093
13VRK22.69360312
14TRIM282.66079694
15PBK2.65655911
16TSSK62.57175111
17PLK42.38936004
18INSRR2.30054112
19PDK22.18412538
20MAP3K122.02251887
21MAP3K102.01683959
22WEE11.96225362
23TYK21.95872678
24TAOK31.90178418
25PTK61.87372186
26LATS11.81567062
27STK161.78994648
28MST1R1.76419628
29PLK31.75813266
30CAMK1D1.73818611
31EEF2K1.72234382
32NEK91.71646043
33PIK3CG1.70755173
34SCYL21.65465293
35TGFBR21.56341309
36NUAK11.54304858
37ZAK1.53761999
38NME11.52784929
39IRAK31.49488080
40TGFBR11.48344598
41VRK11.46178841
42MAP2K31.44213691
43CDK61.43329839
44JAK31.42549439
45MAP3K31.41211829
46RIPK11.39432487
47FGFR31.38941537
48PLK11.38889947
49FRK1.35312662
50ERBB31.27171971
51BCR1.24584452
52MKNK11.23287659
53MAPK111.22850501
54PASK1.21994495
55EIF2AK21.21365956
56BRSK11.15368364
57JAK21.14923085
58TBK11.09982795
59CDK41.09895646
60CSNK1G31.07167427
61LRRK21.06183214
62PDGFRA1.06103406
63WNK31.04809393
64JAK11.03847617
65MKNK20.99812617
66TESK20.99105929
67ACVR1B0.97877227
68TAF10.97590397
69STK30.96843024
70MAP2K70.96646390
71ATR0.95136957
72NME20.93639787
73CSNK1G10.93247360
74KDR0.93022317
75CDK70.92764737
76BRSK20.92563155
77TESK10.91536411
78RPS6KA40.89221678
79MAP3K140.89107680
80CSNK1G20.88154925
81AURKB0.85840878
82CHEK20.85008215
83RPS6KB20.83942217
84EPHA30.83095769
85TIE10.81819959
86PRKAA20.81379161
87STK240.77879402
88PIM20.77873966
89MAPKAPK30.74529953
90KIT0.74284323
91BMPR1B0.73029729
92NEK10.72654886
93PIK3CA0.72435894
94STK390.69709960
95ERBB40.68492031
96MAP3K20.67919331
97ABL20.67803309
98CAMK1G0.67240433
99CDC70.66989252
100CSNK1A1L0.66856282
101MAP4K10.66609302
102MYLK0.65998844
103CSF1R0.65651120
104FGFR20.63522628
105DYRK1B0.63354376
106AURKA0.61871806
107TTN0.61260273
108DAPK10.61004188
109LMTK20.60499848
110CSNK2A10.60467220
111OBSCN0.60183475
112MAPKAPK50.59996645
113MAPK40.59906642
114MAP3K40.58571772
115BTK0.58360657
116ZAP700.57856188
117ATM0.56874484
118CHEK10.55420983
119RET0.55336873
120EIF2AK30.52977485
121TEC0.52931996
122MTOR0.52374963
123TNIK0.51981653
124DYRK30.51688985
125CSNK2A20.51268928
126IRAK10.51101031
127MAP3K70.50003992
128FGFR10.49273039
129TLK10.48794345
130CHUK0.48781809
131MET0.48762244
132STK38L0.48710193
133IGF1R0.48310791
134NEK60.48037998
135RPS6KA50.47631134
136MAP2K40.47593217
137PRKAA10.47150076
138PDK30.46388474
139PDK40.46388474
140ERBB20.46226470
141MAP3K110.46057598
142BRD40.45802158
143ALK0.45791153
144PTK20.45656440
145IKBKE0.45515180
146GSK3A0.45169432
147OXSR10.44175008
148MAP3K80.43816946
149STK40.43171017
150MAP3K50.41767184
151DMPK0.41429312
152CSK0.40226743
153ILK0.39405532
154CCNB10.39007336
155PRKACG0.38515792
156MUSK0.38231479
157GRK70.37606992
158PAK40.37307028
159BRAF0.36977373
160CSNK1E0.36156875
161GRK60.34114620
162CDK90.33639925
163IRAK40.33238646
164STK100.33163394
165PRKG20.32292523
166MAPK150.32060483
167AKT20.30808542
168PLK20.30143996
169CAMK2D0.30092805
170BMPR20.27597273
171SIK30.27232815
172PRKCI0.26548187
173CDK10.26033490
174CDK20.25993592

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001203.89916598
2Proteasome_Homo sapiens_hsa030503.74959127
3Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.17212289
4Nitrogen metabolism_Homo sapiens_hsa009103.10783056
5Fatty acid degradation_Homo sapiens_hsa000712.94546386
6Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.77177675
7Tryptophan metabolism_Homo sapiens_hsa003802.70928071
8Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.66549279
9Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.66500618
10Mismatch repair_Homo sapiens_hsa034302.55881278
11Propanoate metabolism_Homo sapiens_hsa006402.52183529
12Arginine biosynthesis_Homo sapiens_hsa002202.51537799
13Complement and coagulation cascades_Homo sapiens_hsa046102.35785967
14Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.32129169
15PPAR signaling pathway_Homo sapiens_hsa033202.24341056
16Pentose and glucuronate interconversions_Homo sapiens_hsa000402.16384416
17Fatty acid metabolism_Homo sapiens_hsa012122.12683497
18Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.08927294
19Peroxisome_Homo sapiens_hsa041462.04190654
20Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.01441147
21Base excision repair_Homo sapiens_hsa034101.97508930
22Caffeine metabolism_Homo sapiens_hsa002321.95679426
23Butanoate metabolism_Homo sapiens_hsa006501.95487928
24beta-Alanine metabolism_Homo sapiens_hsa004101.87858829
25Drug metabolism - other enzymes_Homo sapiens_hsa009831.86042659
26Non-homologous end-joining_Homo sapiens_hsa034501.83922540
272-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.83153612
28Selenocompound metabolism_Homo sapiens_hsa004501.78836589
29Protein export_Homo sapiens_hsa030601.78162904
30Homologous recombination_Homo sapiens_hsa034401.75873016
31Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.73714892
32Staphylococcus aureus infection_Homo sapiens_hsa051501.72048575
33Parkinsons disease_Homo sapiens_hsa050121.71991196
34Oxidative phosphorylation_Homo sapiens_hsa001901.69996281
35Histidine metabolism_Homo sapiens_hsa003401.66812794
36Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.65025480
37Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.63503086
38RNA polymerase_Homo sapiens_hsa030201.57816557
39Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.55952180
40Spliceosome_Homo sapiens_hsa030401.55776462
41Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.55587060
42Maturity onset diabetes of the young_Homo sapiens_hsa049501.54252977
43Phenylalanine metabolism_Homo sapiens_hsa003601.54139554
44Chemical carcinogenesis_Homo sapiens_hsa052041.53158257
45Pyruvate metabolism_Homo sapiens_hsa006201.50948068
46RNA transport_Homo sapiens_hsa030131.50655685
47Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.50537864
48Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.49766310
49Steroid hormone biosynthesis_Homo sapiens_hsa001401.48319635
50Fat digestion and absorption_Homo sapiens_hsa049751.45046664
51Retinol metabolism_Homo sapiens_hsa008301.44275338
52Folate biosynthesis_Homo sapiens_hsa007901.42466060
53Nucleotide excision repair_Homo sapiens_hsa034201.41756691
54Carbon metabolism_Homo sapiens_hsa012001.41636910
55Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.37106055
56Fanconi anemia pathway_Homo sapiens_hsa034601.34441688
57Tyrosine metabolism_Homo sapiens_hsa003501.31128173
58Starch and sucrose metabolism_Homo sapiens_hsa005001.30484616
59Sulfur metabolism_Homo sapiens_hsa009201.25187849
60Cell cycle_Homo sapiens_hsa041101.21763468
61ABC transporters_Homo sapiens_hsa020101.18653315
62Bile secretion_Homo sapiens_hsa049761.18229790
63Cysteine and methionine metabolism_Homo sapiens_hsa002701.15862435
64Biosynthesis of amino acids_Homo sapiens_hsa012301.14006582
65Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.13581705
66RNA degradation_Homo sapiens_hsa030181.11097905
67One carbon pool by folate_Homo sapiens_hsa006701.10070973
68Lysine degradation_Homo sapiens_hsa003101.08962847
69Fatty acid elongation_Homo sapiens_hsa000621.08060787
70Huntingtons disease_Homo sapiens_hsa050161.01008531
71Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.98657791
72Basal transcription factors_Homo sapiens_hsa030220.97088381
73Cyanoamino acid metabolism_Homo sapiens_hsa004600.92068345
74Sulfur relay system_Homo sapiens_hsa041220.89822202
75Ribosome_Homo sapiens_hsa030100.89411837
76Glycerolipid metabolism_Homo sapiens_hsa005610.88501792
77Purine metabolism_Homo sapiens_hsa002300.85208902
78Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.83184173
79Alzheimers disease_Homo sapiens_hsa050100.76793836
80Fatty acid biosynthesis_Homo sapiens_hsa000610.75486675
81Pentose phosphate pathway_Homo sapiens_hsa000300.74979885
82Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.73390924
83Vitamin digestion and absorption_Homo sapiens_hsa049770.72843838
84Arginine and proline metabolism_Homo sapiens_hsa003300.72597013
85Insulin resistance_Homo sapiens_hsa049310.68105698
86Glutathione metabolism_Homo sapiens_hsa004800.68037726
87Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.67658657
88mRNA surveillance pathway_Homo sapiens_hsa030150.65810030
89Oocyte meiosis_Homo sapiens_hsa041140.58457089
90Adipocytokine signaling pathway_Homo sapiens_hsa049200.55781196
91p53 signaling pathway_Homo sapiens_hsa041150.47759069
92Cardiac muscle contraction_Homo sapiens_hsa042600.46128471
93Galactose metabolism_Homo sapiens_hsa000520.43318888
94Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.41677797
95AMPK signaling pathway_Homo sapiens_hsa041520.39976196
96Metabolic pathways_Homo sapiens_hsa011000.39014817
97Steroid biosynthesis_Homo sapiens_hsa001000.37936151
98Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.37876320
99Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.36241833
100Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.28898124
101Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.28632089
102Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.27312404
103Vitamin B6 metabolism_Homo sapiens_hsa007500.24346557
104Glucagon signaling pathway_Homo sapiens_hsa049220.23863517
105Prion diseases_Homo sapiens_hsa050200.21749463
106Fructose and mannose metabolism_Homo sapiens_hsa000510.21400334
107Legionellosis_Homo sapiens_hsa051340.20992525
108TGF-beta signaling pathway_Homo sapiens_hsa043500.20347588
109Thyroid cancer_Homo sapiens_hsa052160.19456972
110Insulin signaling pathway_Homo sapiens_hsa049100.16810693
111Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.14737504
112DNA replication_Homo sapiens_hsa030300.12144005
113alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.11436469
114Central carbon metabolism in cancer_Homo sapiens_hsa052300.10615134
115N-Glycan biosynthesis_Homo sapiens_hsa005100.08299699
116Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.07344401
117Pyrimidine metabolism_Homo sapiens_hsa002400.06716110
118Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.06499047
119RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.05603324
120Linoleic acid metabolism_Homo sapiens_hsa005910.01955578
121Renin-angiotensin system_Homo sapiens_hsa046140.01786938
122Hepatitis C_Homo sapiens_hsa051600.00650113
123Amoebiasis_Homo sapiens_hsa05146-0.0467115
124Pertussis_Homo sapiens_hsa05133-0.0397433
125Acute myeloid leukemia_Homo sapiens_hsa05221-0.0279752
126Antigen processing and presentation_Homo sapiens_hsa04612-0.0254582
127Longevity regulating pathway - mammal_Homo sapiens_hsa04211-0.0203347
128Toll-like receptor signaling pathway_Homo sapiens_hsa04620-0.0136050
129Glycosaminoglycan degradation_Homo sapiens_hsa00531-0.0106921
130Protein digestion and absorption_Homo sapiens_hsa04974-0.0073026
131Herpes simplex infection_Homo sapiens_hsa05168-0.0054996

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »