ISOC2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1proline biosynthetic process (GO:0006561)5.33798584
2negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)4.98935735
3NADH metabolic process (GO:0006734)4.75028380
4Golgi transport vesicle coating (GO:0048200)4.66862098
5COPI coating of Golgi vesicle (GO:0048205)4.66862098
6proline metabolic process (GO:0006560)4.56710134
7urea cycle (GO:0000050)4.26818817
8ribosomal small subunit biogenesis (GO:0042274)4.23919093
9protein maturation by protein folding (GO:0022417)4.18308306
10protein retention in ER lumen (GO:0006621)4.17936552
11urea metabolic process (GO:0019627)4.17178050
12GDP-mannose metabolic process (GO:0019673)3.96546407
13maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.91521151
14erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.86544476
15L-phenylalanine metabolic process (GO:0006558)3.86544476
16nitrogen cycle metabolic process (GO:0071941)3.81820997
17pentose-phosphate shunt (GO:0006098)3.67705087
18L-serine metabolic process (GO:0006563)3.51660164
19peptidyl-arginine omega-N-methylation (GO:0035247)3.48593933
20oxaloacetate metabolic process (GO:0006107)3.46870804
21monosaccharide biosynthetic process (GO:0046364)3.46672204
22retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.46580647
23peptidyl-glutamic acid carboxylation (GO:0017187)3.45852085
24protein carboxylation (GO:0018214)3.45852085
25negative regulation of cell size (GO:0045792)3.45517460
26regulation of mammary gland epithelial cell proliferation (GO:0033599)3.43738243
27gluconeogenesis (GO:0006094)3.38958265
28glucose catabolic process (GO:0006007)3.35346996
29regulation of translational fidelity (GO:0006450)3.28265597
30glutamine family amino acid biosynthetic process (GO:0009084)3.27282006
31hexose biosynthetic process (GO:0019319)3.25300957
32NADPH regeneration (GO:0006740)3.24665363
33nucleobase-containing small molecule interconversion (GO:0015949)3.11308517
34pentose metabolic process (GO:0019321)3.11141044
35glucose 6-phosphate metabolic process (GO:0051156)3.08081359
36histone arginine methylation (GO:0034969)3.04292475
37mitotic chromosome condensation (GO:0007076)3.04260354
38mitochondrial fusion (GO:0008053)3.03538911
39DNA unwinding involved in DNA replication (GO:0006268)3.01964924
404-hydroxyproline metabolic process (GO:0019471)3.01880755
41positive regulation of lipoprotein lipase activity (GO:0051006)2.99379803
42positive regulation of triglyceride lipase activity (GO:0061365)2.99379803
43formation of translation preinitiation complex (GO:0001731)2.97545930
44erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)2.96048783
45L-phenylalanine catabolic process (GO:0006559)2.96048783
46viral transcription (GO:0019083)2.95391432
47regulation of cholesterol biosynthetic process (GO:0045540)2.92839335
48serine family amino acid biosynthetic process (GO:0009070)2.92274778
49apoptotic process involved in morphogenesis (GO:0060561)2.92176071
50tricarboxylic acid metabolic process (GO:0072350)2.89696966
51UV protection (GO:0009650)2.87329952
52regulation of cholesterol homeostasis (GO:2000188)2.83622854
53regulation of early endosome to late endosome transport (GO:2000641)2.80867756
54nuclear envelope reassembly (GO:0031468)2.79737773
55mitotic nuclear envelope reassembly (GO:0007084)2.79737773
56negative regulation of release of cytochrome c from mitochondria (GO:0090201)2.76946139
57maturation of SSU-rRNA (GO:0030490)2.76299732
58sulfur amino acid catabolic process (GO:0000098)2.74585994
59glyoxylate metabolic process (GO:0046487)2.70052987
60tricarboxylic acid cycle (GO:0006099)2.67581662
61positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling2.66430875
62fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.64733392
63translational termination (GO:0006415)2.64580810
64endoplasmic reticulum calcium ion homeostasis (GO:0032469)2.63985019
65fructose metabolic process (GO:0006000)2.62352232
66cellular modified amino acid catabolic process (GO:0042219)2.62091043
67pinocytosis (GO:0006907)2.61474387
68peptidyl-arginine N-methylation (GO:0035246)2.61255583
69peptidyl-arginine methylation (GO:0018216)2.61255583
70folic acid metabolic process (GO:0046655)2.61057916
71maternal placenta development (GO:0001893)2.58850624
72translational elongation (GO:0006414)2.56925119
73alpha-linolenic acid metabolic process (GO:0036109)2.55314279
74deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.55096849
75regulation of glucose import in response to insulin stimulus (GO:2001273)2.52979252
76regulation of cholesterol esterification (GO:0010872)2.51380800
77focal adhesion assembly (GO:0048041)2.50835701
78cell-substrate adherens junction assembly (GO:0007045)2.50835701
79negative regulation of fibrinolysis (GO:0051918)2.49432494
80ribonucleoprotein complex biogenesis (GO:0022613)2.47627615
81barbed-end actin filament capping (GO:0051016)2.46974462
82adherens junction assembly (GO:0034333)2.46251376
83positive regulation of fatty acid biosynthetic process (GO:0045723)2.45482595
84ribosomal small subunit assembly (GO:0000028)2.45043062
85protein insertion into membrane (GO:0051205)2.44960024
86regulation of fibrinolysis (GO:0051917)2.43600853
87NADP metabolic process (GO:0006739)2.42450953
88glycolytic process (GO:0006096)2.41588035
89regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway 2.41133216
90nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.40255949
91regulation of cholesterol metabolic process (GO:0090181)2.39277228
92rRNA transcription (GO:0009303)2.38845666
93viral life cycle (GO:0019058)2.38184305
94regulation of plasminogen activation (GO:0010755)2.37132731
95basement membrane organization (GO:0071711)2.36982249
96protein localization to endosome (GO:0036010)2.36335351
97low-density lipoprotein particle clearance (GO:0034383)2.32919901
98purine ribonucleotide transport (GO:0015868)2.32241040
99spliceosomal tri-snRNP complex assembly (GO:0000244)2.30397297
100heterochromatin organization (GO:0070828)2.30133151

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.23799697
2EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.10311903
3PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.08354963
4ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.55830077
5HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.52877109
6* LXR_22292898_ChIP-Seq_THP-1_Human2.43417879
7MYC_18555785_ChIP-Seq_MESCs_Mouse2.34420318
8TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse2.33909394
9VDR_21846776_ChIP-Seq_THP-1_Human2.33168374
10RARG_19884340_ChIP-ChIP_MEFs_Mouse2.26513318
11ZNF263_19887448_ChIP-Seq_K562_Human2.25672804
12TP63_17297297_ChIP-ChIP_HaCaT_Human2.20575079
13E2F7_22180533_ChIP-Seq_HELA_Human2.19447379
14MYC_18358816_ChIP-ChIP_MESCs_Mouse2.03484035
15MYC_22102868_ChIP-Seq_BL_Human2.02259679
16ELK3_25401928_ChIP-Seq_HUVEC_Human2.01042669
17RACK7_27058665_Chip-Seq_MCF-7_Human1.95966383
18DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.88576948
19NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.88280541
20THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.86195985
21CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.81523050
22MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.75527398
23TET1_21451524_ChIP-Seq_MESCs_Mouse1.72067485
24XRN2_22483619_ChIP-Seq_HELA_Human1.71156383
25JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.68660493
26SRY_22984422_ChIP-ChIP_TESTIS_Rat1.65517887
27MYC_19079543_ChIP-ChIP_MESCs_Mouse1.63751450
28ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.61366312
29THAP11_20581084_ChIP-Seq_MESCs_Mouse1.58090286
30MYC_19030024_ChIP-ChIP_MESCs_Mouse1.54665762
31ZFX_18555785_ChIP-Seq_MESCs_Mouse1.54152855
32TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.54145457
33KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.53778918
34P68_20966046_ChIP-Seq_HELA_Human1.53600187
35KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.50016926
36RXR_22158963_ChIP-Seq_LIVER_Mouse1.46656060
37PPARA_22158963_ChIP-Seq_LIVER_Mouse1.43930006
38KLF4_18555785_ChIP-Seq_MESCs_Mouse1.41516443
39CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.38985037
40NELFA_20434984_ChIP-Seq_ESCs_Mouse1.37658060
41ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.34988174
42SA1_27219007_Chip-Seq_ERYTHROID_Human1.33015994
43SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.32482768
44UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.32451510
45E2F1_18555785_ChIP-Seq_MESCs_Mouse1.30602692
46NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.30452915
47KDM2B_26808549_Chip-Seq_SUP-B15_Human1.30326427
48CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.29432649
49STAT3_1855785_ChIP-Seq_MESCs_Mouse1.29227555
50CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.28791392
51ELF1_20517297_ChIP-Seq_JURKAT_Human1.28719002
52CTCF_27219007_Chip-Seq_ERYTHROID_Human1.27910226
53ERG_21242973_ChIP-ChIP_JURKAT_Human1.27588601
54ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.26635830
55SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.25746411
56FOXM1_23109430_ChIP-Seq_U2OS_Human1.25736332
57CLOCK_20551151_ChIP-Seq_293T_Human1.22451013
58NANOG_18555785_ChIP-Seq_MESCs_Mouse1.22338857
59ESR1_15608294_ChIP-ChIP_MCF-7_Human1.21590936
60HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.21393764
61KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.20908140
62NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.19131145
63SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.18791400
64ATF3_27146783_Chip-Seq_COLON_Human1.18565084
65DCP1A_22483619_ChIP-Seq_HELA_Human1.17915309
66GABP_19822575_ChIP-Seq_HepG2_Human1.17387751
67* KDM2B_26808549_Chip-Seq_DND41_Human1.17234117
68NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.17228123
69ETS1_20019798_ChIP-Seq_JURKAT_Human1.17034442
70CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.16986873
71ZFP281_18757296_ChIP-ChIP_E14_Mouse1.16688592
72SMC4_20622854_ChIP-Seq_HELA_Human1.16503291
73TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.16181422
74SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.14925280
75POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.14291783
76* FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.13969318
77TCF7_22412390_ChIP-Seq_EML_Mouse1.13099690
78CTCF_18555785_ChIP-Seq_MESCs_Mouse1.12305715
79CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.11257312
80TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.10010480
81ESR2_21235772_ChIP-Seq_MCF-7_Human1.09968111
82* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.09351556
83BCOR_27268052_Chip-Seq_Bcells_Human1.08650825
84POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.08633431
85ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.08500948
86CREB1_26743006_Chip-Seq_LNCaP_Human1.07950654
87KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.07829891
88PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.07337203
89SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.07182734
90OCT4_18692474_ChIP-Seq_MEFs_Mouse1.06810970
91* NCOR1_26117541_ChIP-Seq_K562_Human1.06382175
92RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.06371806
93CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.05421267
94YY1_21170310_ChIP-Seq_MESCs_Mouse1.05045003
95FOXP1_21924763_ChIP-Seq_HESCs_Human1.04357543
96BCL6_27268052_Chip-Seq_Bcells_Human1.04179483
97RARA_24833708_ChIP-Seq_LIVER_Mouse1.03900099
98CTCF_26484167_Chip-Seq_Bcells_Mouse1.03200718
99EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.02546117
100SETDB1_19884255_ChIP-Seq_MESCs_Mouse1.02075255

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005451_abnormal_body_composition4.24278443
2MP0003705_abnormal_hypodermis_morpholog3.92265060
3MP0009840_abnormal_foam_cell3.51093828
4MP0002139_abnormal_hepatobiliary_system3.31594740
5MP0005058_abnormal_lysosome_morphology3.10191573
6MP0005360_urolithiasis3.01594978
7MP0004233_abnormal_muscle_weight2.52796681
8MP0000751_myopathy2.43143389
9MP0003191_abnormal_cellular_cholesterol2.39599976
10MP0004185_abnormal_adipocyte_glucose2.33002260
11MP0010030_abnormal_orbit_morphology2.31023296
12MP0005365_abnormal_bile_salt2.11762166
13MP0004858_abnormal_nervous_system2.11033535
14MP0008438_abnormal_cutaneous_collagen2.05842041
15MP0003806_abnormal_nucleotide_metabolis2.00495471
16MP0003693_abnormal_embryo_hatching1.98646922
17MP0005670_abnormal_white_adipose1.96212971
18MP0008260_abnormal_autophagy1.88542754
19MP0002877_abnormal_melanocyte_morpholog1.83281445
20MP0000678_abnormal_parathyroid_gland1.81873693
21MP0001661_extended_life_span1.80739476
22MP0000747_muscle_weakness1.73600891
23MP0005666_abnormal_adipose_tissue1.69398254
24MP0002796_impaired_skin_barrier1.68796066
25MP0000750_abnormal_muscle_regeneration1.68571885
26MP0005501_abnormal_skin_physiology1.66908962
27MP0005257_abnormal_intraocular_pressure1.57977917
28MP0001849_ear_inflammation1.57871749
29MP0003111_abnormal_nucleus_morphology1.55192325
30MP0010234_abnormal_vibrissa_follicle1.51601546
31MP0005076_abnormal_cell_differentiation1.49187377
32MP0000003_abnormal_adipose_tissue1.48401296
33MP0002249_abnormal_larynx_morphology1.48222241
34MP0003566_abnormal_cell_adhesion1.48177667
35MP0005330_cardiomyopathy1.46938809
36MP0000749_muscle_degeneration1.44392311
37MP0005375_adipose_tissue_phenotype1.43732496
38MP0004957_abnormal_blastocyst_morpholog1.41687893
39MP0000759_abnormal_skeletal_muscle1.41098068
40MP0002089_abnormal_postnatal_growth/wei1.36255687
41MP0001730_embryonic_growth_arrest1.34451473
42MP0009379_abnormal_foot_pigmentation1.33940876
43MP0005083_abnormal_biliary_tract1.33143765
44MP0003186_abnormal_redox_activity1.31205621
45MP0005085_abnormal_gallbladder_physiolo1.27634772
46MP0006036_abnormal_mitochondrial_physio1.27286770
47MP0003329_amyloid_beta_deposits1.26902628
48MP0003453_abnormal_keratinocyte_physiol1.26480490
49MP0000537_abnormal_urethra_morphology1.23387113
50MP0004087_abnormal_muscle_fiber1.23317196
51MP0000609_abnormal_liver_physiology1.17264658
52MP0009672_abnormal_birth_weight1.16042538
53MP0009278_abnormal_bone_marrow1.15114924
54MP0000733_abnormal_muscle_development1.15040088
55MP0000858_altered_metastatic_potential1.13780909
56MP0008875_abnormal_xenobiotic_pharmacok1.12244134
57MP0005332_abnormal_amino_acid1.10891492
58MP0008932_abnormal_embryonic_tissue1.08807262
59MP0003123_paternal_imprinting1.08326079
60MP0005623_abnormal_meninges_morphology1.06689206
61MP0004272_abnormal_basement_membrane1.05716907
62MP0009333_abnormal_splenocyte_physiolog1.05466379
63MP0003077_abnormal_cell_cycle1.02760996
64MP0009053_abnormal_anal_canal0.96915488
65MP0002269_muscular_atrophy0.96885284
66MP0001666_abnormal_nutrient_absorption0.93799766
67MP0002060_abnormal_skin_morphology0.93515995
68MP0002080_prenatal_lethality0.93431739
69MP0000604_amyloidosis0.91080856
70MP0005319_abnormal_enzyme/_coenzyme0.88695859
71MP0000490_abnormal_crypts_of0.88339819
72MP0000350_abnormal_cell_proliferation0.86122562
73MP0005584_abnormal_enzyme/coenzyme_acti0.85960647
74MP0010630_abnormal_cardiac_muscle0.85399767
75MP0000343_altered_response_to0.85287135
76MP0000467_abnormal_esophagus_morphology0.82255277
77MP0002971_abnormal_brown_adipose0.81338733
78MP0009931_abnormal_skin_appearance0.77830336
79MP0001727_abnormal_embryo_implantation0.77414812
80MP0002118_abnormal_lipid_homeostasis0.76432666
81MP0002970_abnormal_white_adipose0.75900750
82MP0000598_abnormal_liver_morphology0.75764308
83MP0003959_abnormal_lean_body0.74948729
84MP0000313_abnormal_cell_death0.74516701
85MP0003315_abnormal_perineum_morphology0.73362560
86MP0006035_abnormal_mitochondrial_morpho0.71785552
87MP0009643_abnormal_urine_homeostasis0.71214696
88MP0003075_altered_response_to0.70517260
89MP0003868_abnormal_feces_composition0.70356065
90MP0010329_abnormal_lipoprotein_level0.68187771
91MP0001346_abnormal_lacrimal_gland0.67398938
92MP0001348_abnormal_lacrimal_gland0.67105001
93MP0000358_abnormal_cell_content/0.66649636
94MP0003942_abnormal_urinary_system0.64965801
95MP0001216_abnormal_epidermal_layer0.64806130
96MP0002106_abnormal_muscle_physiology0.64720617
97MP0005023_abnormal_wound_healing0.64586328
98MP0001915_intracranial_hemorrhage0.64467174
99MP0005165_increased_susceptibility_to0.63939763
100MP0004782_abnormal_surfactant_physiolog0.63671120

Predicted human phenotypes

RankGene SetZ-score
1Deep venous thrombosis (HP:0002625)3.81609731
2Achilles tendon contracture (HP:0001771)3.60485997
3Abnormality of the Achilles tendon (HP:0005109)3.48393913
4Abnormal gallbladder physiology (HP:0012438)3.46572496
5Cholecystitis (HP:0001082)3.46572496
6Abnormality of monocarboxylic acid metabolism (HP:0010996)3.35007019
7Distal lower limb muscle weakness (HP:0009053)3.29316685
8Vertebral compression fractures (HP:0002953)3.27253869
9Ragged-red muscle fibers (HP:0003200)3.06642759
10Myopathic facies (HP:0002058)3.06596971
11Premature rupture of membranes (HP:0001788)2.99461087
12Hyperacusis (HP:0010780)2.97160237
13Progressive muscle weakness (HP:0003323)2.87454310
14Centrally nucleated skeletal muscle fibers (HP:0003687)2.86398714
15Increased connective tissue (HP:0009025)2.80647452
16Abnormality of aromatic amino acid family metabolism (HP:0004338)2.80358485
17Abnormality of glycolysis (HP:0004366)2.73388911
18Protrusio acetabuli (HP:0003179)2.72018729
19Distal lower limb amyotrophy (HP:0008944)2.67801022
20Exercise-induced myalgia (HP:0003738)2.58524843
21Abnormality of complement system (HP:0005339)2.53740028
22Rhabdomyolysis (HP:0003201)2.51818153
23Reticulocytosis (HP:0001923)2.50879051
24Hemorrhage of the eye (HP:0011885)2.46780361
25Increased serum pyruvate (HP:0003542)2.46635421
26Systemic lupus erythematosus (HP:0002725)2.44738333
27Cholelithiasis (HP:0001081)2.38830537
28Distal upper limb amyotrophy (HP:0007149)2.36427134
29Upper limb amyotrophy (HP:0009129)2.36427134
30Back pain (HP:0003418)2.34863652
31Insomnia (HP:0100785)2.33440465
32Aplasia/Hypoplasia of the sacrum (HP:0008517)2.28748128
33Ulnar bowing (HP:0003031)2.28137062
34Generalized amyotrophy (HP:0003700)2.26365556
35Xanthomatosis (HP:0000991)2.24846542
36Trismus (HP:0000211)2.24655318
37Complement deficiency (HP:0004431)2.23396374
38Bulbar palsy (HP:0001283)2.21467949
39Type 1 muscle fiber predominance (HP:0003803)2.18962620
40Abnormality of reticulocytes (HP:0004312)2.14234160
41Mildly elevated creatine phosphokinase (HP:0008180)2.14168462
42Stridor (HP:0010307)2.08911500
43Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.07923765
44Biconcave vertebral bodies (HP:0004586)2.05796750
45Hyperammonemia (HP:0001987)2.05432637
46Muscle fiber inclusion bodies (HP:0100299)2.04036022
47Abnormality of skeletal muscle fiber size (HP:0012084)2.04029138
48Testicular atrophy (HP:0000029)2.02387600
49Nemaline bodies (HP:0003798)2.01288329
50Short nail (HP:0001799)2.00864569
51Broad distal phalanx of finger (HP:0009836)1.99642424
52Increased variability in muscle fiber diameter (HP:0003557)1.98725740
53Abnormal gallbladder morphology (HP:0012437)1.96300607
54Prolonged partial thromboplastin time (HP:0003645)1.94161845
55Abnormality of long-chain fatty-acid metabolism (HP:0010964)1.94138150
56Abnormality of the distal phalanges of the toes (HP:0010182)1.93908086
57Abnormality of the thoracic spine (HP:0100711)1.93838408
58Round ear (HP:0100830)1.92183744
59Spinal rigidity (HP:0003306)1.90181780
60Muscle stiffness (HP:0003552)1.89612934
61Elbow flexion contracture (HP:0002987)1.88103590
62Abnormality of the gallbladder (HP:0005264)1.87716881
63Abnormality of the umbilical cord (HP:0010881)1.81991966
64Increased muscle lipid content (HP:0009058)1.81939706
65Myoglobinuria (HP:0002913)1.81504807
66Multiple enchondromatosis (HP:0005701)1.78829070
67Abnormality of cells of the erythroid lineage (HP:0012130)1.78619100
68Axonal loss (HP:0003447)1.76908696
69Abnormality of pyrimidine metabolism (HP:0004353)1.76805820
70Nonimmune hydrops fetalis (HP:0001790)1.75723992
71Thoracic kyphosis (HP:0002942)1.75471890
72Thin bony cortex (HP:0002753)1.75267324
73Hand muscle atrophy (HP:0009130)1.74579103
74Microvesicular hepatic steatosis (HP:0001414)1.73644077
75Rough bone trabeculation (HP:0100670)1.72731330
76Diaphragmatic weakness (HP:0009113)1.72584791
77Overriding aorta (HP:0002623)1.72016066
78Increased serum ferritin (HP:0003281)1.71676098
79Abnormality of the tricuspid valve (HP:0001702)1.70947762
80Prolonged neonatal jaundice (HP:0006579)1.70901490
81J-shaped sella turcica (HP:0002680)1.70836245
82Ulnar deviation of the wrist (HP:0003049)1.70408482
83Polygenic inheritance (HP:0010982)1.68756290
84Hyperparathyroidism (HP:0000843)1.68633723
85Reduced antithrombin III activity (HP:0001976)1.68372639
86Acanthosis nigricans (HP:0000956)1.68221684
87Long palpebral fissure (HP:0000637)1.67238794
88Gout (HP:0001997)1.67189947
89Multiple lipomas (HP:0001012)1.64176311
90Hypokinesia (HP:0002375)1.64022176
91Flat acetabular roof (HP:0003180)1.63379460
92Disproportionate tall stature (HP:0001519)1.63332229
93Asymmetric septal hypertrophy (HP:0001670)1.62312432
94Abnormality of glutamine family amino acid metabolism (HP:0010902)1.61603238
95Premature skin wrinkling (HP:0100678)1.61600447
96Hypertensive crisis (HP:0100735)1.61291197
97Hypercholesterolemia (HP:0003124)1.60812422
98Blue sclerae (HP:0000592)1.60675635
99Athetosis (HP:0002305)1.60465226
100Hypertriglyceridemia (HP:0002155)1.60421685

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIB34.73507160
2NME24.21747910
3SMG13.78301781
4IRAK32.99491930
5ERN12.92113274
6EEF2K2.67414514
7SIK12.54879401
8ICK2.53198467
9PRPF4B2.38050290
10TESK12.33937817
11TESK22.06886382
12VRK22.03677703
13EPHA22.02617571
14ARAF1.90472868
15TTN1.90066628
16MAP3K111.80222262
17TAOK21.66335093
18PIM21.63059336
19PKN21.51021334
20SCYL21.48208949
21PAK41.39590828
22RPS6KB21.38394348
23BCKDK1.34894830
24BRAF1.34443133
25RIPK11.26357162
26BUB11.20947568
27LMTK21.20550643
28LIMK11.18906592
29STK161.10500819
30FGFR41.09108997
31AURKA1.07701190
32MAP3K101.07657613
33MST1R1.05586972
34NEK11.04799075
35MAPKAPK31.01089854
36ILK1.01014783
37MAP2K30.99762729
38DAPK30.98103426
39MAP3K80.97414502
40ABL20.95558763
41LRRK20.93472443
42PRKD30.91361354
43CDK70.89033048
44MAPK110.83804328
45MTOR0.82829348
46CDK120.82271614
47AKT20.81245031
48MUSK0.80078397
49LATS20.78442634
50MAP2K20.78407076
51PTK20.76979074
52PDPK10.76327028
53BMX0.72703997
54PRKG20.72665479
55PTK60.72514483
56MAP3K10.71196315
57KSR20.70846624
58PBK0.67358553
59KDR0.66338049
60CDK80.65046511
61PDGFRA0.63644345
62CDK40.63020532
63EPHB20.62354379
64TBK10.61430546
65RPS6KA20.60684531
66MAP3K30.59674768
67CDC70.59370474
68PRKCI0.58455766
69TTK0.56882691
70PRKD20.56722726
71PAK10.53188318
72CHEK20.52499075
73AURKB0.52015452
74DAPK10.51505476
75RPS6KC10.51249982
76RPS6KL10.51249982
77TAOK10.49108546
78BRSK10.47867768
79MARK20.47773400
80CDK11A0.47466113
81IRAK20.46960428
82NME10.46801311
83CAMK2G0.46489457
84PHKG20.44126795
85PHKG10.44126795
86NEK20.43718680
87CAMK1D0.43450012
88CDK150.42480939
89PAK20.38981031
90CDC42BPA0.37707102
91DDR20.37528530
92PDK20.36876943
93CCNB10.35709484
94CDK180.35431604
95CDK90.35170084
96CDK140.34852098
97MOS0.34565610
98STK40.34155369
99EIF2AK10.30694082
100CHEK10.30596409

Predicted pathways (KEGG)

RankGene SetZ-score
1Sulfur relay system_Homo sapiens_hsa041223.47953872
22-Oxocarboxylic acid metabolism_Homo sapiens_hsa012103.31887146
3Citrate cycle (TCA cycle)_Homo sapiens_hsa000203.25453887
4Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.14718761
5Biosynthesis of amino acids_Homo sapiens_hsa012303.00693965
6Cyanoamino acid metabolism_Homo sapiens_hsa004602.66624456
7Pentose phosphate pathway_Homo sapiens_hsa000302.58862259
8Fructose and mannose metabolism_Homo sapiens_hsa000512.45142943
9Carbon metabolism_Homo sapiens_hsa012002.44789197
10Arginine biosynthesis_Homo sapiens_hsa002202.25801708
11Phenylalanine metabolism_Homo sapiens_hsa003602.25233332
12Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.14518137
13DNA replication_Homo sapiens_hsa030302.06074837
14Ribosome_Homo sapiens_hsa030102.03313936
15Pyruvate metabolism_Homo sapiens_hsa006201.93682784
16Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.92847516
17Galactose metabolism_Homo sapiens_hsa000521.87648055
18Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.73660612
19Other glycan degradation_Homo sapiens_hsa005111.64932661
20Base excision repair_Homo sapiens_hsa034101.63293665
21Arginine and proline metabolism_Homo sapiens_hsa003301.59331641
22Vitamin B6 metabolism_Homo sapiens_hsa007501.51258581
23Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.49758246
24Prion diseases_Homo sapiens_hsa050201.48388362
25Tyrosine metabolism_Homo sapiens_hsa003501.44528741
26Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.35643794
27Central carbon metabolism in cancer_Homo sapiens_hsa052301.33261705
28Cysteine and methionine metabolism_Homo sapiens_hsa002701.31635856
29Fatty acid elongation_Homo sapiens_hsa000621.30294987
30Fatty acid degradation_Homo sapiens_hsa000711.23714330
31Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.19568891
32Drug metabolism - other enzymes_Homo sapiens_hsa009831.17918395
33Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.17385511
34Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.16560011
35Primary bile acid biosynthesis_Homo sapiens_hsa001201.16026731
36Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.15267953
37Complement and coagulation cascades_Homo sapiens_hsa046101.13660938
38Bladder cancer_Homo sapiens_hsa052191.13476705
39Sulfur metabolism_Homo sapiens_hsa009201.11745419
40Folate biosynthesis_Homo sapiens_hsa007901.09570248
41Glycosaminoglycan degradation_Homo sapiens_hsa005311.09438896
42Glutathione metabolism_Homo sapiens_hsa004801.04934407
43Pyrimidine metabolism_Homo sapiens_hsa002401.03717677
44Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.00767726
45Pentose and glucuronate interconversions_Homo sapiens_hsa000400.96530710
46PPAR signaling pathway_Homo sapiens_hsa033200.94381683
47Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.93670132
48Fatty acid metabolism_Homo sapiens_hsa012120.93460944
49One carbon pool by folate_Homo sapiens_hsa006700.88656342
50N-Glycan biosynthesis_Homo sapiens_hsa005100.83583746
51Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.78942735
52Systemic lupus erythematosus_Homo sapiens_hsa053220.75714403
53Insulin signaling pathway_Homo sapiens_hsa049100.72590321
54Mismatch repair_Homo sapiens_hsa034300.72530077
55AMPK signaling pathway_Homo sapiens_hsa041520.72327854
56Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.72214696
57Chronic myeloid leukemia_Homo sapiens_hsa052200.69047249
58Starch and sucrose metabolism_Homo sapiens_hsa005000.67536741
59Vibrio cholerae infection_Homo sapiens_hsa051100.67519531
60Acute myeloid leukemia_Homo sapiens_hsa052210.65650488
61Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.64505639
62Thyroid cancer_Homo sapiens_hsa052160.63765345
63Fat digestion and absorption_Homo sapiens_hsa049750.59075258
64Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.57814136
65Bile secretion_Homo sapiens_hsa049760.57662326
66Metabolic pathways_Homo sapiens_hsa011000.54713052
67Histidine metabolism_Homo sapiens_hsa003400.54018727
68Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.53031853
69Nucleotide excision repair_Homo sapiens_hsa034200.50577458
70Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.50176383
71Lysine degradation_Homo sapiens_hsa003100.50022717
72Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.49374051
73Spliceosome_Homo sapiens_hsa030400.49009293
74Retinol metabolism_Homo sapiens_hsa008300.48935585
75Lysosome_Homo sapiens_hsa041420.48254186
76Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.47158946
77beta-Alanine metabolism_Homo sapiens_hsa004100.46416971
78Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.43739564
79Non-small cell lung cancer_Homo sapiens_hsa052230.43514816
80Adipocytokine signaling pathway_Homo sapiens_hsa049200.43074615
81Peroxisome_Homo sapiens_hsa041460.42835900
82Insulin resistance_Homo sapiens_hsa049310.41372844
83Chemical carcinogenesis_Homo sapiens_hsa052040.41142479
84Glucagon signaling pathway_Homo sapiens_hsa049220.40470238
85VEGF signaling pathway_Homo sapiens_hsa043700.40045438
86Notch signaling pathway_Homo sapiens_hsa043300.38927350
87Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.38733902
88Steroid hormone biosynthesis_Homo sapiens_hsa001400.38574773
89Pancreatic cancer_Homo sapiens_hsa052120.35773809
90Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.33720753
91Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.33341035
92Viral carcinogenesis_Homo sapiens_hsa052030.32984931
93Renin-angiotensin system_Homo sapiens_hsa046140.32897473
94Alcoholism_Homo sapiens_hsa050340.30776490
95Huntingtons disease_Homo sapiens_hsa050160.30700368
96Proteasome_Homo sapiens_hsa030500.30452104
97Steroid biosynthesis_Homo sapiens_hsa001000.30232553
98Cell cycle_Homo sapiens_hsa041100.28467745
99Fatty acid biosynthesis_Homo sapiens_hsa000610.26846747
100Apoptosis_Homo sapiens_hsa042100.26425486

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