IST1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein with MIT-interacting motifs that interacts with components of endosomal sorting complexes required for transport (ESCRT). ESCRT functions in vesicle budding, such as that which occurs during membrane abscission in cytokinesis. There is a pseudogene for this gene on chromosome 19. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1limb bud formation (GO:0060174)4.99347713
2lens morphogenesis in camera-type eye (GO:0002089)4.00899143
3positive regulation of gamma-delta T cell activation (GO:0046645)4.00613241
4poly(A)+ mRNA export from nucleus (GO:0016973)3.83521385
5COPI coating of Golgi vesicle (GO:0048205)3.83121170
6Golgi transport vesicle coating (GO:0048200)3.83121170
7pyrimidine nucleobase catabolic process (GO:0006208)3.68301863
8histone H3-K36 demethylation (GO:0070544)3.67510523
9activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c (GO3.62036267
10central nervous system myelination (GO:0022010)3.59502331
11axon ensheathment in central nervous system (GO:0032291)3.59502331
12positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)3.51257862
13detection of other organism (GO:0098543)3.47464094
14cellular hyperosmotic response (GO:0071474)3.36660926
15histone lysine demethylation (GO:0070076)3.30515902
16positive regulation of pseudopodium assembly (GO:0031274)3.29103033
17histone demethylation (GO:0016577)3.26996108
18amyloid precursor protein catabolic process (GO:0042987)3.26931621
19regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)3.23778911
20detection of bacterium (GO:0016045)3.22703017
21negative regulation of axon guidance (GO:1902668)3.21267994
22viral protein processing (GO:0019082)3.21204725
23positive regulation of receptor biosynthetic process (GO:0010870)3.19804887
24histone H3-K9 demethylation (GO:0033169)3.18534929
25cullin deneddylation (GO:0010388)3.18120111
26chaperone mediated protein folding requiring cofactor (GO:0051085)3.17740135
27positive regulation of B cell differentiation (GO:0045579)3.17288091
28negative regulation of mast cell activation (GO:0033004)3.14635067
29negative regulation of epidermal growth factor-activated receptor activity (GO:0007175)3.11693088
30metallo-sulfur cluster assembly (GO:0031163)3.11116673
31iron-sulfur cluster assembly (GO:0016226)3.11116673
32respiratory burst (GO:0045730)3.03652463
33regulation of T-helper 1 cell differentiation (GO:0045625)3.03640502
34histamine secretion (GO:0001821)3.03618829
35protein deneddylation (GO:0000338)3.02713532
36negative regulation of axon extension involved in axon guidance (GO:0048843)3.01921132
37negative thymic T cell selection (GO:0045060)3.01832279
38response to interleukin-15 (GO:0070672)3.01813105
39oligodendrocyte development (GO:0014003)3.01366610
40protein dealkylation (GO:0008214)3.01332603
41protein demethylation (GO:0006482)3.01332603
42keratinocyte development (GO:0003334)3.00047820
43somite development (GO:0061053)2.97080293
44Arp2/3 complex-mediated actin nucleation (GO:0034314)2.93767317
45negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.93660972
46negative regulation of cell killing (GO:0031342)2.93660972
47regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.92916433
48germinal center formation (GO:0002467)2.92552160
49immunoglobulin mediated immune response (GO:0016064)2.92165638
50positive regulation of oligodendrocyte differentiation (GO:0048714)2.90675839
51plasma lipoprotein particle assembly (GO:0034377)2.90047239
52regulation of pseudopodium assembly (GO:0031272)2.87511167
53regulation of dendritic cell antigen processing and presentation (GO:0002604)2.84749366
54antigen processing and presentation of endogenous antigen (GO:0019883)2.84007847
553-UTR-mediated mRNA stabilization (GO:0070935)2.83185816
56response to muramyl dipeptide (GO:0032495)2.82629805
57cerebral cortex radially oriented cell migration (GO:0021799)2.81293455
58embryonic digestive tract morphogenesis (GO:0048557)2.80073505
59regulation of B cell receptor signaling pathway (GO:0050855)2.79166793
60hyperosmotic salinity response (GO:0042538)2.76417203
61endosome to melanosome transport (GO:0035646)2.76222970
62endosome to pigment granule transport (GO:0043485)2.76222970
63alpha-linolenic acid metabolic process (GO:0036109)2.75556623
64negative T cell selection (GO:0043383)2.75045029
65regulation of somitogenesis (GO:0014807)2.74586673
66piRNA metabolic process (GO:0034587)2.73167530
67synapsis (GO:0007129)2.72735889
68negative regulation of mesenchymal cell apoptotic process (GO:2001054)2.71385918
69energy homeostasis (GO:0097009)2.70102448
70B cell mediated immunity (GO:0019724)2.67997467
71histone H3-K9 methylation (GO:0051567)2.66981277
72fucosylation (GO:0036065)2.66687542
73tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.66641713
74RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.66641713
75amino sugar catabolic process (GO:0046348)2.66369100
76leukocyte aggregation (GO:0070486)2.65980017
77dosage compensation (GO:0007549)2.64590266
78positive regulation by symbiont of host defense response (GO:0052509)2.63938866
79modulation by symbiont of host defense response (GO:0052031)2.63938866
80modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.63938866
81modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.63938866
82positive regulation by organism of defense response of other organism involved in symbiotic interact2.63938866
83modulation by symbiont of host immune response (GO:0052553)2.63938866
84histone H4-K5 acetylation (GO:0043981)2.62885198
85histone H4-K8 acetylation (GO:0043982)2.62885198
86protein neddylation (GO:0045116)2.59951133
87histamine transport (GO:0051608)2.59458703
88negative regulation of T cell differentiation in thymus (GO:0033085)2.58612779
89establishment of viral latency (GO:0019043)2.58290539
90negative regulation of protein tyrosine kinase activity (GO:0061099)2.58263738
91dopaminergic neuron differentiation (GO:0071542)2.57629907
92negative regulation of glycoprotein biosynthetic process (GO:0010561)2.56851265
93nucleotide-binding oligomerization domain containing signaling pathway (GO:0070423)2.56421074
94eyelid development in camera-type eye (GO:0061029)2.55139922
95positive regulation of actin filament depolymerization (GO:0030836)2.54322273
96tricarboxylic acid metabolic process (GO:0072350)2.52669660
97positive regulation of T-helper 1 type immune response (GO:0002827)2.52600089
98fibroblast migration (GO:0010761)2.52120014
99positive regulation of interleukin-12 production (GO:0032735)2.50918824
100neural tube formation (GO:0001841)2.50129308
101positive regulation of alpha-beta T cell proliferation (GO:0046641)2.49218254
102viral mRNA export from host cell nucleus (GO:0046784)2.48961059
103neuron fate determination (GO:0048664)2.48757004
104Notch receptor processing (GO:0007220)2.48171960
105regulation of T-helper 1 type immune response (GO:0002825)2.47785213
106pancreas development (GO:0031016)2.47202921
107mesenchymal cell differentiation involved in kidney development (GO:0072161)2.47006568
108mesenchymal cell differentiation involved in renal system development (GO:2001012)2.47006568
109regulation of B cell differentiation (GO:0045577)2.46556213
110positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:19021102.46518497
111mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)2.46518497
112antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.45879795
113histone H4 deacetylation (GO:0070933)2.45100730
114antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.44761131
115nucleobase catabolic process (GO:0046113)2.43421620
116NIK/NF-kappaB signaling (GO:0038061)2.42928301
117histone H2A acetylation (GO:0043968)2.42923386
118facial nerve structural organization (GO:0021612)2.42107414
119spliceosomal tri-snRNP complex assembly (GO:0000244)2.41904600
120regulation of superoxide anion generation (GO:0032928)2.41824881
121protein-lipid complex assembly (GO:0065005)2.41448611
122GMP metabolic process (GO:0046037)2.41280044
123establishment of integrated proviral latency (GO:0075713)2.41202590
124spinal cord association neuron differentiation (GO:0021527)2.41187396
125positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.40844474
126histone H3-K9 modification (GO:0061647)2.40619694
127fatty acid elongation (GO:0030497)2.40496234
128regulation of gamma-delta T cell activation (GO:0046643)2.40213388
129establishment of mitochondrion localization (GO:0051654)2.40149540
130regulation of alpha-beta T cell proliferation (GO:0046640)2.39808500
131negative chemotaxis (GO:0050919)2.38798188
132male meiosis (GO:0007140)2.37723601
133positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.37638129
134cell differentiation involved in metanephros development (GO:0072202)2.37360979
135regulation of Arp2/3 complex-mediated actin nucleation (GO:0034315)2.37174905
136purine deoxyribonucleoside triphosphate metabolic process (GO:0009215)2.36210763
137regulation of vitamin metabolic process (GO:0030656)2.35094104
138histone H4-K16 acetylation (GO:0043984)2.34529777
139glucosamine-containing compound catabolic process (GO:1901072)2.34249410
140neutrophil activation (GO:0042119)2.34002165
141positive regulation of granulocyte differentiation (GO:0030854)2.33985014
142regulation of interleukin-12 biosynthetic process (GO:0045075)2.33693809
143B cell receptor signaling pathway (GO:0050853)2.30314546
144DNA integration (GO:0015074)2.29601078
145positive regulation of erythrocyte differentiation (GO:0045648)2.29275075
146regulation of oxidative stress-induced neuron death (GO:1903203)2.29027262
147B cell homeostasis (GO:0001782)2.28736530
148cranial nerve morphogenesis (GO:0021602)2.27750555
149cytoplasmic pattern recognition receptor signaling pathway (GO:0002753)2.27271183
150signal peptide processing (GO:0006465)2.26603590
151granulocyte activation (GO:0036230)2.25065354
152T cell migration (GO:0072678)2.24872786
153nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway (GO:0035872)2.24598629
154histone H4-K12 acetylation (GO:0043983)2.23617856
155cellular response to interleukin-15 (GO:0071350)2.23507495
156negative regulation of inflammatory response to antigenic stimulus (GO:0002862)2.23167509
157regulation of chromatin silencing (GO:0031935)2.23134015
158chondrocyte proliferation (GO:0035988)2.22958665
159cornea development in camera-type eye (GO:0061303)2.22574001
160regulation of oligodendrocyte differentiation (GO:0048713)2.22423823
161regulation of mesenchymal cell apoptotic process (GO:2001053)2.22303915
162DNA ligation (GO:0006266)2.22268861
163epithelial cell differentiation involved in prostate gland development (GO:0060742)2.19620614
164negative regulation by host of viral transcription (GO:0043922)2.19564827
165positive regulation of mitochondrial fission (GO:0090141)2.19039430
166positive regulation of toll-like receptor signaling pathway (GO:0034123)2.18510158
167regulation of translation in response to stress (GO:0043555)2.16432797
168negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.15328426
169glial cell development (GO:0021782)2.15128428
170positive regulation of antigen processing and presentation (GO:0002579)2.14642106
171transcription elongation from RNA polymerase III promoter (GO:0006385)2.14241935
172termination of RNA polymerase III transcription (GO:0006386)2.14241935
173positive regulation of intracellular steroid hormone receptor signaling pathway (GO:0033145)2.14051868
174neutrophil activation involved in immune response (GO:0002283)2.13803544
175negative regulation of interleukin-17 production (GO:0032700)2.13685514
176cellular response to exogenous dsRNA (GO:0071360)2.13132570
177positive regulation of interleukin-2 production (GO:0032743)2.12960549
178amyloid precursor protein metabolic process (GO:0042982)2.12718539
179regulation of autophagic vacuole assembly (GO:2000785)2.12579276
180response to peptidoglycan (GO:0032494)2.12265295
181regulation of mast cell activation (GO:0033003)2.11199360
182regulation of alternative mRNA splicing, via spliceosome (GO:0000381)2.10855370
183skin morphogenesis (GO:0043589)2.08475408
184photoreceptor cell differentiation (GO:0046530)2.07796693

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_21731497_ChIP-ChIP_J774_Mouse4.21598699
2ELF1_17652178_ChIP-ChIP_JURKAT_Human4.06507576
3E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.59055199
4IRF8_22096565_ChIP-ChIP_GC-B_Human3.49056177
5CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human3.29979126
6NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.19597375
7HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.96237003
8TP63_17297297_ChIP-ChIP_HaCaT_Human2.95295542
9GABP_17652178_ChIP-ChIP_JURKAT_Human2.95024548
10SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.90115253
11FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.88877895
12IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.88380301
13TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.77449988
14CBX2_27304074_Chip-Seq_ESCs_Mouse2.76241925
15KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.66711729
16TP63_19390658_ChIP-ChIP_HaCaT_Human2.56975992
17SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.52932930
18CREB1_15753290_ChIP-ChIP_HEK293T_Human2.35291609
19POU5F1_16153702_ChIP-ChIP_HESCs_Human2.28547867
20CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.13275286
21JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.11457404
22TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.10350203
23ZFP57_27257070_Chip-Seq_ESCs_Mouse2.03405723
24SCL_19346495_ChIP-Seq_HPC-7_Human2.01063183
25HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.00697132
26FOXP3_21729870_ChIP-Seq_TREG_Human1.93769238
27SRF_21415370_ChIP-Seq_HL-1_Mouse1.85148886
28KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.84528141
29KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.84528141
30KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.84528141
31STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.83326262
32HOXB4_20404135_ChIP-ChIP_EML_Mouse1.79391565
33* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.74834121
34BMI1_23680149_ChIP-Seq_NPCS_Mouse1.74464970
35PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.74460829
36TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.74321688
37EST1_17652178_ChIP-ChIP_JURKAT_Human1.73839181
38DCP1A_22483619_ChIP-Seq_HELA_Human1.72290458
39MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.72010582
40YY1_21170310_ChIP-Seq_MESCs_Mouse1.71900346
41SPI1_23547873_ChIP-Seq_NB4_Human1.69725296
42VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.67801433
43MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.67410880
44PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.59154990
45GABP_19822575_ChIP-Seq_HepG2_Human1.58656810
46HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.57203917
47STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.56023687
48CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.55370245
49ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.54482494
50MYB_26560356_Chip-Seq_TH2_Human1.54306134
51CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.53147565
52VDR_23849224_ChIP-Seq_CD4+_Human1.46757059
53GATA1_26923725_Chip-Seq_HPCs_Mouse1.44304779
54FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.43686923
55SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.42588352
56CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.42457767
57MYCN_18555785_ChIP-Seq_MESCs_Mouse1.41212810
58IRF1_19129219_ChIP-ChIP_H3396_Human1.40956138
59NANOG_21062744_ChIP-ChIP_HESCs_Human1.38920793
60RBPJ_22232070_ChIP-Seq_NCS_Mouse1.38322688
61FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.37796189
62TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.37148432
63THAP11_20581084_ChIP-Seq_MESCs_Mouse1.34993172
64SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.34490267
65RNF2_27304074_Chip-Seq_NSC_Mouse1.34239705
66NOTCH1_21737748_ChIP-Seq_TLL_Human1.34170129
67TFEB_21752829_ChIP-Seq_HELA_Human1.34150350
68CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.33979605
69ELK1_19687146_ChIP-ChIP_HELA_Human1.33190389
70PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.33156319
71TTF2_22483619_ChIP-Seq_HELA_Human1.30589526
72BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.30268239
73NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.28812839
74UTX_26944678_Chip-Seq_JUKART_Human1.28672251
75CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.28200732
76EWS_26573619_Chip-Seq_HEK293_Human1.26913104
77RUNX_20019798_ChIP-Seq_JUKART_Human1.25468991
78E2F1_18555785_ChIP-Seq_MESCs_Mouse1.23733804
79CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.22322779
80SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.20702375
81KDM5A_27292631_Chip-Seq_BREAST_Human1.19480075
82EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.19343027
83POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.19167557
84MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.18399672
85ELK1_22589737_ChIP-Seq_MCF10A_Human1.18233386
86ZFX_18555785_ChIP-Seq_MESCs_Mouse1.17020625
87IRF8_27001747_Chip-Seq_BMDM_Mouse1.16320353
88RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.15579424
89DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.14335301
90VDR_22108803_ChIP-Seq_LS180_Human1.13833073
91MYB_26560356_Chip-Seq_TH1_Human1.13831344
92GATA3_27048872_Chip-Seq_THYMUS_Human1.13069973
93MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.12825604
94CIITA_25753668_ChIP-Seq_RAJI_Human1.11705009
95CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.11381682
96ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.10720899
97XRN2_22483619_ChIP-Seq_HELA_Human1.10675284
98YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.10064900
99KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.09813619
100NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.09238368
101FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.08755160
102SOX2_16153702_ChIP-ChIP_HESCs_Human1.08302669
103MYC_18358816_ChIP-ChIP_MESCs_Mouse1.07593699
104CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.07011731
105STAT4_19710469_ChIP-ChIP_TH1__Mouse1.06287389
106HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.01215458
107MYC_18555785_ChIP-Seq_MESCs_Mouse1.00150037
108ETS1_20019798_ChIP-Seq_JURKAT_Human1.00116855
109TAL1_26923725_Chip-Seq_HPCs_Mouse0.98709141
110CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.98409679
111EGR1_19374776_ChIP-ChIP_THP-1_Human0.98236525
112STAT6_20620947_ChIP-Seq_CD4_POS_T_Human0.97470098
113BP1_19119308_ChIP-ChIP_Hs578T_Human0.96251902
114SOX2_20726797_ChIP-Seq_SW620_Human0.96212007
115MYC_19030024_ChIP-ChIP_MESCs_Mouse0.96110865
116NANOG_16153702_ChIP-ChIP_HESCs_Human0.94990599
117RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.93731225
118PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.93697787
119SALL1_21062744_ChIP-ChIP_HESCs_Human0.91398896
120EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.89070824
121GBX2_23144817_ChIP-Seq_PC3_Human0.89041779
122KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.88987235
123ERG_20887958_ChIP-Seq_HPC-7_Mouse0.88614418
124NELFA_20434984_ChIP-Seq_ESCs_Mouse0.87560611
125OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.86758479
126POU3F2_20337985_ChIP-ChIP_501MEL_Human0.86239607
127IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.86224548
128PADI4_21655091_ChIP-ChIP_MCF-7_Human0.85536220
129SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.85349545
130IGF1R_20145208_ChIP-Seq_DFB_Human0.83628572
131CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.83446158
132CLOCK_20551151_ChIP-Seq_293T_Human0.82605573
133EZH2_27304074_Chip-Seq_ESCs_Mouse0.80194730
134GATA1_22025678_ChIP-Seq_K562_Human0.79820010
135TAF15_26573619_Chip-Seq_HEK293_Human0.79562347
136ER_23166858_ChIP-Seq_MCF-7_Human0.79398166
137STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.78893676
138GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.77599681
139PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.77108712
140ZNF274_21170338_ChIP-Seq_K562_Hela0.76790010
141SOX17_20123909_ChIP-Seq_XEN_Mouse0.76473146
142SALL4_22934838_ChIP-ChIP_CD34+_Human0.76324808
143CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.76079876
144PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.74178415

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000566_synostosis5.14618606
2MP0000569_abnormal_digit_pigmentation4.22648223
3MP0006054_spinal_hemorrhage3.56192452
4MP0008260_abnormal_autophagy3.28547137
5MP0008877_abnormal_DNA_methylation3.04990636
6MP0005394_taste/olfaction_phenotype2.72760287
7MP0005499_abnormal_olfactory_system2.72760287
8MP0008789_abnormal_olfactory_epithelium2.54414969
9MP0003303_peritoneal_inflammation2.51480099
10MP0004147_increased_porphyrin_level2.47491224
11MP0003183_abnormal_peptide_metabolism2.41212485
12MP0004264_abnormal_extraembryonic_tissu2.33648104
13MP0003221_abnormal_cardiomyocyte_apopto2.20307921
14MP0005671_abnormal_response_to2.13699698
15MP0005058_abnormal_lysosome_morphology2.12437930
16MP0009785_altered_susceptibility_to2.10244336
17MP0001346_abnormal_lacrimal_gland2.07013190
18MP0000778_abnormal_nervous_system2.05476763
19MP0001188_hyperpigmentation2.03953921
20MP0005075_abnormal_melanosome_morpholog1.93919720
21MP0000647_abnormal_sebaceous_gland1.90585005
22MP0010030_abnormal_orbit_morphology1.85565853
23MP0001835_abnormal_antigen_presentation1.83746864
24MP0002148_abnormal_hypersensitivity_rea1.77575987
25MP0003172_abnormal_lysosome_physiology1.76224538
26MP0006292_abnormal_olfactory_placode1.75471670
27MP0001984_abnormal_olfaction1.74406240
28MP0002254_reproductive_system_inflammat1.73082148
29MP0005248_abnormal_Harderian_gland1.72275492
30MP0000383_abnormal_hair_follicle1.65478422
31MP0002938_white_spotting1.63901000
32MP0003567_abnormal_fetal_cardiomyocyte1.61704039
33MP0002653_abnormal_ependyma_morphology1.57781500
34MP0003121_genomic_imprinting1.57236363
35MP0000681_abnormal_thyroid_gland1.56486973
36MP0000467_abnormal_esophagus_morphology1.56405776
37MP0002751_abnormal_autonomic_nervous1.51463873
38MP0001529_abnormal_vocalization1.50475825
39MP0003943_abnormal_hepatobiliary_system1.49754104
40MP0004782_abnormal_surfactant_physiolog1.48103509
41MP0008007_abnormal_cellular_replicative1.42176965
42MP0005025_abnormal_response_to1.38504878
43MP0008058_abnormal_DNA_repair1.37744362
44MP0002234_abnormal_pharynx_morphology1.36689345
45MP0000689_abnormal_spleen_morphology1.36214537
46MP0002722_abnormal_immune_system1.34431633
47MP0003938_abnormal_ear_development1.32284562
48MP0000537_abnormal_urethra_morphology1.31470366
49MP0003787_abnormal_imprinting1.30533941
50MP0002452_abnormal_antigen_presenting1.29174581
51MP0000049_abnormal_middle_ear1.28833497
52MP0003724_increased_susceptibility_to1.27831541
53MP0006082_CNS_inflammation1.27682376
54MP0003122_maternal_imprinting1.26835682
55MP0003436_decreased_susceptibility_to1.26016720
56MP0002405_respiratory_system_inflammati1.24690219
57MP0002098_abnormal_vibrissa_morphology1.24341484
58MP0008057_abnormal_DNA_replication1.23882528
59MP0005000_abnormal_immune_tolerance1.22355403
60MP0010678_abnormal_skin_adnexa1.22353263
61MP0000465_gastrointestinal_hemorrhage1.19274204
62MP0002419_abnormal_innate_immunity1.16898984
63MP0001293_anophthalmia1.15729448
64MP0002420_abnormal_adaptive_immunity1.15599623
65MP0008995_early_reproductive_senescence1.15116251
66MP0001819_abnormal_immune_cell1.14285821
67MP0001533_abnormal_skeleton_physiology1.09958446
68MP0001800_abnormal_humoral_immune1.08361256
69MP0008004_abnormal_stomach_pH1.07241939
70MP0001915_intracranial_hemorrhage1.07005466
71MP0002723_abnormal_immune_serum1.06962894
72MP0000703_abnormal_thymus_morphology1.06897937
73MP0002249_abnormal_larynx_morphology1.06311887
74MP0003656_abnormal_erythrocyte_physiolo1.06168812
75MP0004947_skin_inflammation1.05979478
76MP0006035_abnormal_mitochondrial_morpho1.05446040
77MP0002277_abnormal_respiratory_mucosa1.03565541
78MP0003786_premature_aging1.03559924
79MP0005397_hematopoietic_system_phenotyp1.03074238
80MP0001545_abnormal_hematopoietic_system1.03074238
81MP0009765_abnormal_xenobiotic_induced1.02744209
82MP0002177_abnormal_outer_ear1.02511596
83MP0001851_eye_inflammation1.02477801
84MP0002139_abnormal_hepatobiliary_system1.02244947
85MP0003763_abnormal_thymus_physiology1.02113490
86MP0000685_abnormal_immune_system1.01575045
87MP0003866_abnormal_defecation1.00979036
88MP0003011_delayed_dark_adaptation1.00546559
89MP0005464_abnormal_platelet_physiology1.00405587
90MP0003077_abnormal_cell_cycle0.99784151
91MP0003755_abnormal_palate_morphology0.98796625
92MP0001790_abnormal_immune_system0.97336000
93MP0005387_immune_system_phenotype0.97336000
94MP0001853_heart_inflammation0.97146719
95MP0000015_abnormal_ear_pigmentation0.96167261
96MP0000516_abnormal_urinary_system0.95520236
97MP0005367_renal/urinary_system_phenotyp0.95520236
98MP0003890_abnormal_embryonic-extraembry0.95404738
99MP0005390_skeleton_phenotype0.94395603
100MP0002282_abnormal_trachea_morphology0.94132368
101MP0010386_abnormal_urinary_bladder0.92059097
102MP0002398_abnormal_bone_marrow0.91139904
103MP0001873_stomach_inflammation0.91103685
104MP0001216_abnormal_epidermal_layer0.91099268
105MP0000313_abnormal_cell_death0.90681596
106MP0010155_abnormal_intestine_physiology0.87839701
107MP0003300_gastrointestinal_ulcer0.87715871
108MP0000538_abnormal_urinary_bladder0.87476685
109MP0000490_abnormal_crypts_of0.86776710
110MP0001340_abnormal_eyelid_morphology0.86031385
111MP0001663_abnormal_digestive_system0.85717985
112MP0001764_abnormal_homeostasis0.85232999
113MP0005381_digestive/alimentary_phenotyp0.84797889
114MP0009764_decreased_sensitivity_to0.84441841
115MP0003937_abnormal_limbs/digits/tail_de0.83538711
116MP0005084_abnormal_gallbladder_morpholo0.83530084
117MP0000716_abnormal_immune_system0.82820646
118MP0001666_abnormal_nutrient_absorption0.82724194
119MP0003315_abnormal_perineum_morphology0.82454575
120MP0005253_abnormal_eye_physiology0.82208149
121MP0002116_abnormal_craniofacial_bone0.81925485
122MP0002092_abnormal_eye_morphology0.80558427
123MP0001727_abnormal_embryo_implantation0.79786915
124MP0003693_abnormal_embryo_hatching0.79164905
125MP0001145_abnormal_male_reproductive0.78930052
126MP0005167_abnormal_blood-brain_barrier0.78545936
127MP0001929_abnormal_gametogenesis0.77790424
128MP0000372_irregular_coat_pigmentation0.77435719
129MP0009333_abnormal_splenocyte_physiolog0.77414496
130MP0002089_abnormal_postnatal_growth/wei0.77277293
131MP0004883_abnormal_blood_vessel0.76959961
132MP0008469_abnormal_protein_level0.76906262
133MP0006072_abnormal_retinal_apoptosis0.76694265
134MP0009703_decreased_birth_body0.76682604
135MP0002132_abnormal_respiratory_system0.75800250
136MP0004134_abnormal_chest_morphology0.75533163
137MP0002163_abnormal_gland_morphology0.75253660
138MP0002933_joint_inflammation0.73867579
139MP0008961_abnormal_basal_metabolism0.73586952
140MP0001270_distended_abdomen0.73082306
141MP0002429_abnormal_blood_cell0.72422431
142MP0009840_abnormal_foam_cell0.72229845
143MP0009278_abnormal_bone_marrow0.72189183
144MP0005220_abnormal_exocrine_pancreas0.72135475
145MP0010234_abnormal_vibrissa_follicle0.71083241
146MP0002210_abnormal_sex_determination0.69863046
147MP0009763_increased_sensitivity_to0.69394905
148MP0003942_abnormal_urinary_system0.68873717
149MP0005310_abnormal_salivary_gland0.68757389
150MP0001730_embryonic_growth_arrest0.68166754
151MP0002111_abnormal_tail_morphology0.66546491
152MP0003950_abnormal_plasma_membrane0.65750994
153MP0005451_abnormal_body_composition0.65310441
154MP0000462_abnormal_digestive_system0.63492951
155MP0000762_abnormal_tongue_morphology0.63418726
156MP0001845_abnormal_inflammatory_respons0.62869549

Predicted human phenotypes

RankGene SetZ-score
1Metaphyseal dysplasia (HP:0100255)5.42915141
2Agnosia (HP:0010524)4.07254915
3Hepatoblastoma (HP:0002884)3.68544312
4Microvesicular hepatic steatosis (HP:0001414)3.67030767
5Amyotrophic lateral sclerosis (HP:0007354)3.53428860
6Increased IgM level (HP:0003496)3.49794935
7Broad alveolar ridges (HP:0000187)3.44452025
8Prostate neoplasm (HP:0100787)3.41584884
9Recurrent bacterial skin infections (HP:0005406)3.39795039
10Recurrent abscess formation (HP:0002722)3.21055915
11Short tibia (HP:0005736)3.01117899
12Stomatitis (HP:0010280)2.99789966
13Split foot (HP:0001839)2.86458077
14Stenosis of the external auditory canal (HP:0000402)2.81394247
15Aplasia/Hypoplasia of the tibia (HP:0005772)2.78704051
16Septo-optic dysplasia (HP:0100842)2.70125418
17Abnormality of the intervertebral disk (HP:0005108)2.64664004
18Tubulointerstitial nephritis (HP:0001970)2.63869094
19Alacrima (HP:0000522)2.60688157
20Peripheral hypomyelination (HP:0007182)2.58623327
21Abnormal hair whorl (HP:0010721)2.58047350
22Thickened helices (HP:0000391)2.55838019
23Short middle phalanx of the 5th finger (HP:0004220)2.49691058
24Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.49341890
25Abnormal delayed hypersensitivity skin test (HP:0002963)2.47217780
26Conical tooth (HP:0000698)2.47017782
27Nephrogenic diabetes insipidus (HP:0009806)2.45479333
28Abnormality of the phalanges of the 2nd finger (HP:0009541)2.39790872
29Cholecystitis (HP:0001082)2.37014359
30Abnormal gallbladder physiology (HP:0012438)2.37014359
31Aplasia/Hypoplasia of the clavicles (HP:0006710)2.35152397
32Optic nerve coloboma (HP:0000588)2.33114280
33Abnormality of the labia minora (HP:0012880)2.31765195
34Basal cell carcinoma (HP:0002671)2.31219866
35Aplasia/Hypoplasia of the sternum (HP:0006714)2.29967746
36Cupped ear (HP:0000378)2.29212484
37Cerebral hypomyelination (HP:0006808)2.27810797
38Pancreatic fibrosis (HP:0100732)2.26853990
39Disinhibition (HP:0000734)2.25835683
40Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.23436904
41Congenital primary aphakia (HP:0007707)2.22838832
42Medulloblastoma (HP:0002885)2.21739479
43Stomach cancer (HP:0012126)2.21120756
44Recurrent corneal erosions (HP:0000495)2.20762203
453-Methylglutaconic aciduria (HP:0003535)2.20622300
46Nasolacrimal duct obstruction (HP:0000579)2.20551599
47Mixed hearing impairment (HP:0000410)2.20464953
48Agammaglobulinemia (HP:0004432)2.18760575
49Gonadotropin excess (HP:0000837)2.18374567
50Abnormality of the renal collecting system (HP:0004742)2.17189061
51Xerostomia (HP:0000217)2.15624254
52Shoulder girdle muscle weakness (HP:0003547)2.14142623
53Volvulus (HP:0002580)2.13320467
54True hermaphroditism (HP:0010459)2.13274504
55Eczematoid dermatitis (HP:0000976)2.13115967
56Decreased lacrimation (HP:0000633)2.11622391
57Vacuolated lymphocytes (HP:0001922)2.10975323
58Widely patent fontanelles and sutures (HP:0004492)2.10586811
59Spinal cord lesions (HP:0100561)2.09531158
60Syringomyelia (HP:0003396)2.09531158
61IgM deficiency (HP:0002850)2.09195214
62Autoimmune thrombocytopenia (HP:0001973)2.08739485
63Neurofibrillary tangles (HP:0002185)2.08414071
64Short clavicles (HP:0000894)2.07206846
65Myositis (HP:0100614)2.06618932
66Carpal bone hypoplasia (HP:0001498)2.06479013
67Congenital ichthyosiform erythroderma (HP:0007431)2.06121575
68Neonatal respiratory distress (HP:0002643)2.05223494
69Abnormality of the motor neurons (HP:0002450)2.04621516
70Abnormal neuron morphology (HP:0012757)2.04621516
71Recurrent sinusitis (HP:0011108)2.03536531
72Broad palm (HP:0001169)2.03035195
73Abnormality of the 2nd finger (HP:0004100)2.02188160
74Renal cortical cysts (HP:0000803)2.01808526
75Gait imbalance (HP:0002141)2.01752738
76Vaginal atresia (HP:0000148)2.01691367
77Retrobulbar optic neuritis (HP:0100654)2.01600504
78Optic neuritis (HP:0100653)2.01600504
79Abnormality of macrophages (HP:0004311)2.00627694
80Abnormality of hair growth rate (HP:0011363)1.99937477
81Slow-growing hair (HP:0002217)1.99937477
82Meningitis (HP:0001287)1.97691091
83Medial flaring of the eyebrow (HP:0010747)1.96433997
84Broad foot (HP:0001769)1.96210229
85Nausea (HP:0002018)1.96062415
86Absent septum pellucidum (HP:0001331)1.96010639
87Granulocytopenia (HP:0001913)1.95839180
88Stridor (HP:0010307)1.95751639
89Progressive external ophthalmoplegia (HP:0000590)1.94448551
90Hypoproteinemia (HP:0003075)1.94343537
91Aplasia/Hypoplasia involving the sinuses (HP:0009120)1.93512641
92Weak cry (HP:0001612)1.93455303
93Combined immunodeficiency (HP:0005387)1.92905332
94Abnormality of incisor morphology (HP:0011063)1.92257909
95Loss of speech (HP:0002371)1.92012157
96Elevated erythrocyte sedimentation rate (HP:0003565)1.91604126
97Obstructive lung disease (HP:0006536)1.91159591
98Chronic obstructive pulmonary disease (HP:0006510)1.91159591
99Decreased testicular size (HP:0008734)1.90966797
100Cortical dysplasia (HP:0002539)1.89610871
101Severe combined immunodeficiency (HP:0004430)1.89421840
102Abnormality of the metopic suture (HP:0005556)1.89345335
103Hepatosplenomegaly (HP:0001433)1.88852330
104Type I transferrin isoform profile (HP:0003642)1.87650655
105Partial duplication of thumb phalanx (HP:0009944)1.87642595
106Heterochromia iridis (HP:0001100)1.87621602
107Preaxial hand polydactyly (HP:0001177)1.87121816
108Absent frontal sinuses (HP:0002688)1.86950391
109Panhypogammaglobulinemia (HP:0003139)1.86028283
110Urticaria (HP:0001025)1.86012914
111Petechiae (HP:0000967)1.84995654
112Delayed closure of the anterior fontanelle (HP:0001476)1.83141640
113Orchitis (HP:0100796)1.82310197
114Aplasia/Hypoplasia involving the femoral head and neck (HP:0009108)1.82016715
115Abnormality of the parietal bone (HP:0002696)1.81432458
116Atrophy/Degeneration involving motor neurons (HP:0007373)1.80458814
117Encephalitis (HP:0002383)1.80330047
118Bifid uvula (HP:0000193)1.79559455
119Anteriorly placed anus (HP:0001545)1.79142876
120Degeneration of anterior horn cells (HP:0002398)1.78726332
121Abnormality of the anterior horn cell (HP:0006802)1.78726332
122Short middle phalanx of finger (HP:0005819)1.77708118
123Papillary thyroid carcinoma (HP:0002895)1.75543312
124Anomalous pulmonary venous return (HP:0010772)1.73697283
125Irregular epiphyses (HP:0010582)1.72730632
126Polyphagia (HP:0002591)1.72606766
127Optic nerve hypoplasia (HP:0000609)1.72269711
128Abnormality of the alveolar ridges (HP:0006477)1.71985635
129Abnormality of the lumbar spine (HP:0100712)1.70989041
130Colon cancer (HP:0003003)1.70857885
131Abnormality of the septum pellucidum (HP:0007375)1.70695736
132Pancreatic islet-cell hyperplasia (HP:0004510)1.70623312
133Proximal placement of thumb (HP:0009623)1.69275188
134Abnormal biliary tract physiology (HP:0012439)1.68262918
135Bile duct proliferation (HP:0001408)1.68262918
136Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.67961650
137Neonatal hypoglycemia (HP:0001998)1.66988197
138Recurrent gram-negative bacterial infections (HP:0005420)1.66936855
139Overfolded helix (HP:0000396)1.66853820
140Abnormality of T cell number (HP:0011839)1.66558225
141Recurrent fungal infections (HP:0002841)1.66374032
142Reduced antithrombin III activity (HP:0001976)1.65456184
143Mediastinal lymphadenopathy (HP:0100721)1.65149879
144Acute hepatic failure (HP:0006554)1.65081556
145Lissencephaly (HP:0001339)1.64774052
146Dicarboxylic aciduria (HP:0003215)1.63984005
147Abnormality of dicarboxylic acid metabolism (HP:0010995)1.63984005
148Increased serum pyruvate (HP:0003542)1.63487384
149Clitoromegaly (HP:0000057)1.63431546
150Short femoral neck (HP:0100864)1.63321490
151Abnormality of the pulmonary veins (HP:0011718)1.63194649
152Abnormality of the aortic arch (HP:0012303)1.63085706
153Chronic diarrhea (HP:0002028)1.62383088
154Cutis marmorata (HP:0000965)1.62273041
155Recurrent cutaneous fungal infections (HP:0011370)1.61991724
156Chronic mucocutaneous candidiasis (HP:0002728)1.61991724
157Recurrent skin infections (HP:0001581)1.61276247
158Hyperglycinemia (HP:0002154)1.61028850
159Supernumerary ribs (HP:0005815)1.60970168
160Brushfield spots (HP:0001088)1.60744012
161Patellar aplasia (HP:0006443)1.60546123
162Gastrointestinal atresia (HP:0002589)1.59938192
163Type 2 muscle fiber atrophy (HP:0003554)1.59663658
164Germ cell neoplasia (HP:0100728)1.59378376
165Autoimmune hemolytic anemia (HP:0001890)1.59323370
166Emotional lability (HP:0000712)1.58954395
167Abnormality of the frontal sinuses (HP:0002687)1.58931191
168Exercise-induced muscle cramps (HP:0003710)1.58623067
169Abnormality of eosinophils (HP:0001879)1.58589465
170Rimmed vacuoles (HP:0003805)1.57105785
171Leukocytosis (HP:0001974)1.57046412
172Esotropia (HP:0000565)1.54718814
173IgG deficiency (HP:0004315)1.54305958
174Abnormal pancreas size (HP:0012094)1.53207069
175Megalencephaly (HP:0001355)1.52924795
176Genital tract atresia (HP:0001827)1.52788397
177Limited elbow extension (HP:0001377)1.52063958
178Absent hand (HP:0004050)1.51846629
179Progressive sensorineural hearing impairment (HP:0000408)1.51197323
180Exotropia (HP:0000577)1.50290034
181Corneal erosion (HP:0200020)1.48957220
182Aplasia/Hypoplasia of the 5th finger (HP:0006262)1.48880335
183Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.48645624

Predicted kinase interactions (KEA)

RankGene SetZ-score
1SIK35.18690366
2MAP4K24.69764971
3BCR3.54887372
4BUB13.09139235
5ACVR1B2.99129988
6CDK192.94307429
7SRPK12.63377496
8BMPR1B2.54162028
9MAP3K122.39304579
10MAP3K42.19440710
11BCKDK2.15774010
12ERBB32.15554878
13EPHB22.14524753
14STK162.12087860
15FGFR22.06465848
16FGR1.99069286
17MST41.93349922
18DYRK21.91224269
19LIMK11.76369406
20MAP2K71.72853750
21YES11.72445570
22TYK21.69190750
23RIPK41.63152228
24IRAK41.60635538
25PRPF4B1.59029115
26TBK11.53547672
27KSR11.53205565
28MARK11.52563448
29PBK1.50710584
30PIK3CA1.49892186
31MAP3K141.48061553
32TNIK1.43040147
33MAP2K41.41454423
34BRD41.41362952
35MAP3K51.39711281
36TGFBR11.34514490
37CLK11.33748647
38TESK21.33212654
39TXK1.29861305
40KIT1.28832888
41CDK61.27979672
42CASK1.26653389
43VRK11.25573917
44TAOK31.24814054
45CHUK1.23463660
46MAP3K61.22572528
47DYRK31.21996397
48PASK1.11251556
49MYLK1.10516636
50PIM21.08241371
51FES1.08121222
52MAP3K111.07525248
53BLK1.05271570
54TRIM281.04862285
55MAP3K101.04527432
56IKBKB1.04425117
57UHMK11.04244460
58WNK31.03723591
59DYRK1A1.02619545
60JAK31.02584430
61CSNK1G21.02509697
62EPHA31.01446686
63CSK1.00952636
64SIK21.00883536
65TYRO31.00357861
66LCK1.00143077
67CCNB10.97766528
68RPS6KA40.95966633
69CSF1R0.95632438
70NUAK10.95590095
71FGFR30.93392596
72IRAK30.92425567
73MARK30.91820704
74MAPK130.91651000
75PDK20.91223274
76PINK10.89241281
77HCK0.87638676
78CSNK1G30.86935939
79EIF2AK30.82006905
80MELK0.80618486
81RET0.80202602
82JAK20.79510159
83MAP4K10.78374983
84BMX0.77257977
85BTK0.76332592
86OXSR10.75340249
87ADRBK20.74221408
88MKNK10.71981333
89IKBKE0.71346768
90EIF2AK20.70436295
91SCYL20.69993122
92CSNK1A1L0.68736384
93PTK60.68350423
94MATK0.67378876
95MAPK40.67294688
96NTRK20.66453531
97ERBB20.65134010
98ZAK0.65104642
99MET0.63688872
100TNK20.63120895
101CDK180.62790109
102PIM10.62162011
103FGFR40.61528717
104KSR20.61017037
105MAP2K30.58032316
106RPS6KA60.57957892
107TRPM70.57473076
108PAK30.55115283
109IRAK10.54846922
110CSNK1G10.53948758
111AKT30.52850248
112PLK30.50719278
113TAOK10.50534486
114ATR0.49853258
115ITK0.49651227
116LYN0.49356240
117FYN0.48961545
118RPS6KA20.48195721
119ZAP700.47991051
120SYK0.47823363
121MAPK150.47227570
122ROCK20.46880066
123PKN10.45577531
124RPS6KL10.44655476
125RPS6KC10.44655476
126SGK4940.43319282
127SGK2230.43319282
128ILK0.43153243
129PAK40.43072071
130GRK10.41655938
131STK38L0.41200145
132ERBB40.41001186
133MAPKAPK50.40847157
134EGFR0.39725599
135EPHB10.39675030
136FGFR10.39470805
137TTK0.39424292
138CDK150.39204200
139GRK60.39201869
140CDK140.37563715
141DYRK1B0.36927939
142CDK11A0.36774771
143TESK10.35851755
144RPS6KA50.35507110
145STK390.34833958
146EPHA40.34809391
147TIE10.33918953
148PLK40.32634401
149NEK60.29884612
150MAP3K10.29361386
151PRKCZ0.29261298

Predicted pathways (KEGG)

RankGene SetZ-score
1Pathogenic Escherichia coli infection_Homo sapiens_hsa051302.86159718
2Graft-versus-host disease_Homo sapiens_hsa053322.27371049
3Other glycan degradation_Homo sapiens_hsa005112.25269789
4Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.19758852
5Proteasome_Homo sapiens_hsa030502.17662402
6Leishmaniasis_Homo sapiens_hsa051402.03509238
7Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.00981987
8Shigellosis_Homo sapiens_hsa051311.93327115
9RNA polymerase_Homo sapiens_hsa030201.88607017
10Staphylococcus aureus infection_Homo sapiens_hsa051501.86952799
11Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.85447000
12Notch signaling pathway_Homo sapiens_hsa043301.76684742
13Legionellosis_Homo sapiens_hsa051341.76235668
14Protein export_Homo sapiens_hsa030601.76070455
15Base excision repair_Homo sapiens_hsa034101.75428275
16Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.72590102
17Spliceosome_Homo sapiens_hsa030401.68791514
18Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.64999034
19Rheumatoid arthritis_Homo sapiens_hsa053231.63425076
20Salmonella infection_Homo sapiens_hsa051321.57002068
21Propanoate metabolism_Homo sapiens_hsa006401.56814826
22Allograft rejection_Homo sapiens_hsa053301.54440338
23NF-kappa B signaling pathway_Homo sapiens_hsa040641.53948551
24Glycosaminoglycan degradation_Homo sapiens_hsa005311.44721501
25Sphingolipid metabolism_Homo sapiens_hsa006001.38658893
26Intestinal immune network for IgA production_Homo sapiens_hsa046721.37021667
27Herpes simplex infection_Homo sapiens_hsa051681.36108516
28Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.35650132
29Mismatch repair_Homo sapiens_hsa034301.34924794
30Phagosome_Homo sapiens_hsa041451.34703239
31Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.33775616
32Epstein-Barr virus infection_Homo sapiens_hsa051691.32880899
33Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.30604230
34Pertussis_Homo sapiens_hsa051331.29983417
35NOD-like receptor signaling pathway_Homo sapiens_hsa046211.29169375
36Toll-like receptor signaling pathway_Homo sapiens_hsa046201.28964506
37Selenocompound metabolism_Homo sapiens_hsa004501.28390484
38Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.27742677
39Measles_Homo sapiens_hsa051621.27219587
40Axon guidance_Homo sapiens_hsa043601.26853749
41RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.25996383
42Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.23415584
43Fatty acid metabolism_Homo sapiens_hsa012121.20507322
44Regulation of autophagy_Homo sapiens_hsa041401.18000001
45Basal transcription factors_Homo sapiens_hsa030221.17220826
46Cell cycle_Homo sapiens_hsa041101.13518486
47Collecting duct acid secretion_Homo sapiens_hsa049661.11678344
48Fanconi anemia pathway_Homo sapiens_hsa034601.10031434
49Influenza A_Homo sapiens_hsa051641.06895224
50SNARE interactions in vesicular transport_Homo sapiens_hsa041301.02292434
51Vibrio cholerae infection_Homo sapiens_hsa051101.02207536
52B cell receptor signaling pathway_Homo sapiens_hsa046620.98119812
53mRNA surveillance pathway_Homo sapiens_hsa030150.96865122
54Transcriptional misregulation in cancer_Homo sapiens_hsa052020.96684540
55Hepatitis C_Homo sapiens_hsa051600.96168981
56T cell receptor signaling pathway_Homo sapiens_hsa046600.95499077
57Primary immunodeficiency_Homo sapiens_hsa053400.95433651
58Leukocyte transendothelial migration_Homo sapiens_hsa046700.94975137
59Fructose and mannose metabolism_Homo sapiens_hsa000510.89641916
60Hippo signaling pathway_Homo sapiens_hsa043900.89467714
61Viral myocarditis_Homo sapiens_hsa054160.88806800
62Basal cell carcinoma_Homo sapiens_hsa052170.88768758
63Mineral absorption_Homo sapiens_hsa049780.88455088
64Type I diabetes mellitus_Homo sapiens_hsa049400.88042336
65Steroid biosynthesis_Homo sapiens_hsa001000.88031119
66Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.88021631
67Hedgehog signaling pathway_Homo sapiens_hsa043400.87771744
68Peroxisome_Homo sapiens_hsa041460.86270067
69Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.85107214
70Fatty acid elongation_Homo sapiens_hsa000620.84393954
71Pyrimidine metabolism_Homo sapiens_hsa002400.84318413
72Tuberculosis_Homo sapiens_hsa051520.83963106
73Homologous recombination_Homo sapiens_hsa034400.82380138
74Chemokine signaling pathway_Homo sapiens_hsa040620.82029981
75Arachidonic acid metabolism_Homo sapiens_hsa005900.81895728
76TNF signaling pathway_Homo sapiens_hsa046680.81418466
77Autoimmune thyroid disease_Homo sapiens_hsa053200.80021242
78Hematopoietic cell lineage_Homo sapiens_hsa046400.79432513
79Vitamin digestion and absorption_Homo sapiens_hsa049770.78815012
80Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.78618040
81Lysosome_Homo sapiens_hsa041420.78207058
82Malaria_Homo sapiens_hsa051440.75696458
83Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.75348526
842-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.75343662
85Fat digestion and absorption_Homo sapiens_hsa049750.74870729
86Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.74757942
87Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.74725351
88Colorectal cancer_Homo sapiens_hsa052100.73939367
89Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.73842902
90Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.72452208
91Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.71664243
92Asthma_Homo sapiens_hsa053100.69507604
93Ether lipid metabolism_Homo sapiens_hsa005650.68309432
94African trypanosomiasis_Homo sapiens_hsa051430.68082490
95DNA replication_Homo sapiens_hsa030300.67376769
96RNA degradation_Homo sapiens_hsa030180.67352399
97Osteoclast differentiation_Homo sapiens_hsa043800.67215812
98HTLV-I infection_Homo sapiens_hsa051660.66948278
99Acute myeloid leukemia_Homo sapiens_hsa052210.66455373
100N-Glycan biosynthesis_Homo sapiens_hsa005100.65860500
101Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.65516663
102Carbon metabolism_Homo sapiens_hsa012000.65427721
103Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.64594753
104Purine metabolism_Homo sapiens_hsa002300.62773708
105Adherens junction_Homo sapiens_hsa045200.62631493
106Viral carcinogenesis_Homo sapiens_hsa052030.62629538
107Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.59728172
108Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.59540173
109Renin-angiotensin system_Homo sapiens_hsa046140.59162376
110Jak-STAT signaling pathway_Homo sapiens_hsa046300.58888594
111Hepatitis B_Homo sapiens_hsa051610.57489573
112Nucleotide excision repair_Homo sapiens_hsa034200.56914393
113Non-homologous end-joining_Homo sapiens_hsa034500.56690932
114p53 signaling pathway_Homo sapiens_hsa041150.54995703
115Toxoplasmosis_Homo sapiens_hsa051450.53304746
116Apoptosis_Homo sapiens_hsa042100.52856965
117RNA transport_Homo sapiens_hsa030130.51932778
118Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.51559977
119Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.51424520
120Biosynthesis of amino acids_Homo sapiens_hsa012300.51034590
121Pancreatic cancer_Homo sapiens_hsa052120.50744680
122MicroRNAs in cancer_Homo sapiens_hsa052060.50309529
123Inositol phosphate metabolism_Homo sapiens_hsa005620.49535469
124Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.49493260
125Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.48745439
126Antigen processing and presentation_Homo sapiens_hsa046120.46664941
127Sphingolipid signaling pathway_Homo sapiens_hsa040710.46312007
128Pathways in cancer_Homo sapiens_hsa052000.45626738
129Pentose phosphate pathway_Homo sapiens_hsa000300.44251104
130Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.44126599
131AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.40993925
132Choline metabolism in cancer_Homo sapiens_hsa052310.40423134
133Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.40216372
134Prolactin signaling pathway_Homo sapiens_hsa049170.38573479
135Phosphatidylinositol signaling system_Homo sapiens_hsa040700.37117285

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