ISX

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Homeobox genes encode DNA-binding proteins, many of which are thought to be involved in early embryonic development. Homeobox genes encode a DNA-binding domain of 60 to 63 amino acids referred to as the homeodomain. This gene is a member of the RAXLX homeobox gene family. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cytidine metabolic process (GO:0046087)9.25392178
2cytidine catabolic process (GO:0006216)9.25392178
3cytidine deamination (GO:0009972)9.25392178
4intestinal absorption (GO:0050892)7.71711782
5pyrimidine ribonucleoside catabolic process (GO:0046133)6.71649760
63-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)6.64646103
7purine ribonucleoside bisphosphate metabolic process (GO:0034035)6.64646103
8intestinal cholesterol absorption (GO:0030299)6.39011270
9sulfate transmembrane transport (GO:1902358)6.36758012
10NADH metabolic process (GO:0006734)6.30655682
11regulation of autophagic vacuole assembly (GO:2000785)6.08183353
12epoxygenase P450 pathway (GO:0019373)6.04579904
13negative regulation of macroautophagy (GO:0016242)5.86462620
14lipoprotein transport (GO:0042953)5.76354946
15negative regulation of keratinocyte proliferation (GO:0010839)5.74232405
16bile acid and bile salt transport (GO:0015721)5.73514605
17fat-soluble vitamin biosynthetic process (GO:0042362)5.69580714
18regulation of systemic arterial blood pressure by hormone (GO:0001990)5.44371991
19regulation of systemic arterial blood pressure mediated by a chemical signal (GO:0003044)5.44371991
20endocrine process (GO:0050886)5.44371991
21angiotensin maturation (GO:0002003)5.43962294
22mitochondrial ATP synthesis coupled proton transport (GO:0042776)5.36878950
23sulfate transport (GO:0008272)5.32248441
24intestinal epithelial cell development (GO:0060576)5.05946858
25cellular glucuronidation (GO:0052695)4.91729228
26bundle of His cell to Purkinje myocyte communication (GO:0086069)4.86575686
27regulation of vacuole organization (GO:0044088)4.85027715
28cellular ketone body metabolic process (GO:0046950)4.84681577
29regulation of systemic arterial blood pressure (GO:0003073)4.83570498
30UDP-N-acetylglucosamine metabolic process (GO:0006047)4.81373085
31glucuronate metabolic process (GO:0019585)4.81087378
32uronic acid metabolic process (GO:0006063)4.81087378
33flavonoid metabolic process (GO:0009812)4.80922134
34alkaloid metabolic process (GO:0009820)4.74115547
35hormone catabolic process (GO:0042447)4.73500935
36calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)4.73347357
37fructose metabolic process (GO:0006000)4.71995038
38very-low-density lipoprotein particle assembly (GO:0034379)4.71375701
39sulfur compound transport (GO:0072348)4.70708302
40renal system process involved in regulation of blood volume (GO:0001977)4.69086901
41diacylglycerol metabolic process (GO:0046339)4.67509158
42keratinocyte development (GO:0003334)4.66119367
43ATP synthesis coupled proton transport (GO:0015986)4.65241699
44energy coupled proton transport, down electrochemical gradient (GO:0015985)4.65241699
45negative regulation of epidermal growth factor-activated receptor activity (GO:0007175)4.61234150
46regulation of cellular extravasation (GO:0002691)4.49502314
47protein neddylation (GO:0045116)4.49190637
48regulation of cGMP biosynthetic process (GO:0030826)4.47164091
49regulation of bile acid biosynthetic process (GO:0070857)4.43732455
50plasma lipoprotein particle assembly (GO:0034377)4.42145597
51negative regulation of protein tyrosine kinase activity (GO:0061099)4.40529979
52regulation of guanylate cyclase activity (GO:0031282)4.38891102
53positive regulation of epidermal cell differentiation (GO:0045606)4.37976159
54regulation of respiratory burst (GO:0060263)4.37169876
55drug metabolic process (GO:0017144)4.32969307
56negative regulation of T cell differentiation in thymus (GO:0033085)4.32873168
57positive regulation of T cell differentiation in thymus (GO:0033089)4.31333444
58urea cycle (GO:0000050)4.30190023
59negative regulation of organelle assembly (GO:1902116)4.28468516
60negative regulation of epidermal cell differentiation (GO:0045605)4.26180031
61vitamin A metabolic process (GO:0006776)4.25994503
62positive regulation of respiratory burst (GO:0060267)4.24077103
63actin filament depolymerization (GO:0030042)4.18562405
64ketone body metabolic process (GO:1902224)4.17161786
65urea metabolic process (GO:0019627)4.09634747
66regulation of viral release from host cell (GO:1902186)4.09483610
67protein-lipid complex assembly (GO:0065005)4.03960907
68peptide hormone processing (GO:0016486)4.03771312
69drug catabolic process (GO:0042737)4.00008673
70regulation of keratinocyte proliferation (GO:0010837)3.97007378
71vitamin transmembrane transport (GO:0035461)3.89079123
72pyrimidine-containing compound transmembrane transport (GO:0072531)3.89052228
73chondrocyte proliferation (GO:0035988)3.86126439
74digestive system process (GO:0022600)3.85982174
75fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.85954607
76maintenance of gastrointestinal epithelium (GO:0030277)3.82153987
77glycosphingolipid catabolic process (GO:0046479)3.80981771
78sulfur amino acid catabolic process (GO:0000098)3.80957801
79positive regulation of pseudopodium assembly (GO:0031274)3.80957217
80mitotic G2 DNA damage checkpoint (GO:0007095)3.79634654
81antibacterial humoral response (GO:0019731)3.79111001
82glycolipid catabolic process (GO:0019377)3.77206936
83peptide catabolic process (GO:0043171)3.76565148
84nitrogen cycle metabolic process (GO:0071941)3.75067353
85cGMP-mediated signaling (GO:0019934)3.66975876
86regulation of cGMP metabolic process (GO:0030823)3.64173650
87membrane repolarization during cardiac muscle cell action potential (GO:0086013)3.64167600
88antimicrobial humoral response (GO:0019730)3.62699463
89cellular response to hepatocyte growth factor stimulus (GO:0035729)3.61949372
90response to hepatocyte growth factor (GO:0035728)3.61949372
91renal system process involved in regulation of systemic arterial blood pressure (GO:0003071)3.58111475
92regulation of cholesterol esterification (GO:0010872)3.58000227
93regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)3.56241475
94ribonucleoside bisphosphate biosynthetic process (GO:0034030)3.55665626
95nucleoside bisphosphate biosynthetic process (GO:0033866)3.55665626
96purine nucleoside bisphosphate biosynthetic process (GO:0034033)3.55665626
97homocysteine metabolic process (GO:0050667)3.53036502
98regulation of triglyceride catabolic process (GO:0010896)3.52872550
99pyrimidine nucleoside salvage (GO:0043097)3.52721940
100pyrimidine-containing compound salvage (GO:0008655)3.52721940
101respiratory electron transport chain (GO:0022904)3.52297110
102desmosome organization (GO:0002934)3.51603153
103ethanol oxidation (GO:0006069)3.51188705
104sulfation (GO:0051923)3.48024590
105bicarbonate transport (GO:0015701)3.47379151
106adhesion of symbiont to host (GO:0044406)3.46457311
107positive regulation of glycoprotein biosynthetic process (GO:0010560)3.43725864
108electron transport chain (GO:0022900)3.41618315
109positive regulation of epidermis development (GO:0045684)3.41334954
110positive regulation of guanylate cyclase activity (GO:0031284)3.40688968
111oxidative phosphorylation (GO:0006119)3.39267200
112regulation of pseudopodium assembly (GO:0031272)3.39148267
113nucleoside diphosphate biosynthetic process (GO:0009133)3.38285092
114phospholipid efflux (GO:0033700)3.37479537
115glomerular filtration (GO:0003094)3.34731526
116regulation of hydrogen peroxide metabolic process (GO:0010310)3.33736497
117O-glycan processing (GO:0016266)3.33158474
118glucose 6-phosphate metabolic process (GO:0051156)3.33149310
119nucleoside salvage (GO:0043174)3.32770027
120glutamine family amino acid biosynthetic process (GO:0009084)3.31559071
121positive regulation of lipid catabolic process (GO:0050996)3.28646984
122drug transport (GO:0015893)3.26514790
123bile acid metabolic process (GO:0008206)3.24756239
124positive regulation of glycoprotein metabolic process (GO:1903020)3.22411883
125auditory receptor cell differentiation (GO:0042491)3.22174167
126oligosaccharide biosynthetic process (GO:0009312)3.21492087
127membrane repolarization during action potential (GO:0086011)3.21216799
128receptor guanylyl cyclase signaling pathway (GO:0007168)3.19860449
129regulation of cholesterol homeostasis (GO:2000188)3.15829723
130sodium ion homeostasis (GO:0055078)3.13784313
131keratinocyte proliferation (GO:0043616)3.13272022
132lipoprotein metabolic process (GO:0042157)3.13000531
133drinking behavior (GO:0042756)3.12749173
134negative regulation of epidermis development (GO:0045683)3.12657272
135glycosylceramide metabolic process (GO:0006677)3.12606469
136vitamin transport (GO:0051180)3.12015959
137cGMP biosynthetic process (GO:0006182)3.11743853
138positive regulation of cGMP biosynthetic process (GO:0030828)3.11315521
139ventricular cardiac muscle cell action potential (GO:0086005)3.10337735
140nucleotide-sugar biosynthetic process (GO:0009226)3.08975068
141sperm capacitation (GO:0048240)3.08676698
142ribonucleoside bisphosphate metabolic process (GO:0033875)3.06973532
143nucleoside bisphosphate metabolic process (GO:0033865)3.06973532
144purine nucleoside bisphosphate metabolic process (GO:0034032)3.06973532
145glycerol metabolic process (GO:0006071)3.05591777
146arginine metabolic process (GO:0006525)3.05297033
147sphingomyelin metabolic process (GO:0006684)3.05152043
148epithelial cell-cell adhesion (GO:0090136)3.05148643
149ceramide catabolic process (GO:0046514)3.05042317
150plasma lipoprotein particle organization (GO:0071827)3.02073244
151exogenous drug catabolic process (GO:0042738)3.01340465
152renal filtration (GO:0097205)3.01168707
153sphingolipid catabolic process (GO:0030149)2.99944371
154ATP biosynthetic process (GO:0006754)2.98080259
155positive regulation of fatty acid beta-oxidation (GO:0032000)2.96823213
156regulation of cell-cell adhesion mediated by cadherin (GO:2000047)2.95832509
157activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c (GO2.92151747
158mitotic G2/M transition checkpoint (GO:0044818)2.91866278
159drug transmembrane transport (GO:0006855)2.90146142
160transcytosis (GO:0045056)2.89549216
161phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)2.88758890
162digestion (GO:0007586)2.88635380
163virion attachment to host cell (GO:0019062)2.88139250
164adhesion of symbiont to host cell (GO:0044650)2.88139250
165somite development (GO:0061053)2.87347897

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1CDX2_20551321_ChIP-Seq_CACO-2_Human5.68323103
2TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse4.38723866
3SOX2_27498859_Chip-Seq_STOMACH_Mouse4.08584109
4HNF4A_19761587_ChIP-ChIP_CACO-2_Human3.99072446
5GATA4_25053715_ChIP-Seq_YYC3_Human3.21832723
6SOX2_20726797_ChIP-Seq_SW620_Human3.18505372
7CDX2_19796622_ChIP-Seq_MESCs_Mouse3.04308793
8GATA6_25053715_ChIP-Seq_YYC3_Human3.00185454
9AR_21909140_ChIP-Seq_LNCAP_Human2.79116966
10PPARA_22158963_ChIP-Seq_LIVER_Mouse2.69440046
11ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.57133797
12STAT6_21828071_ChIP-Seq_BEAS2B_Human2.53530287
13SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.36784289
14IRF8_22096565_ChIP-ChIP_GC-B_Human2.26343351
15VDR_22108803_ChIP-Seq_LS180_Human2.25740757
16STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse2.15380615
17SRY_22984422_ChIP-ChIP_TESTIS_Rat2.05857902
18BP1_19119308_ChIP-ChIP_Hs578T_Human2.01927614
19TP63_17297297_ChIP-ChIP_HaCaT_Human10.8357761
20NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.99756949
21TCF4_18268006_ChIP-ChIP_LS174T_Human1.94276800
22FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.94051403
23PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.92624868
24LXR_22158963_ChIP-Seq_LIVER_Mouse1.92490752
25KLF5_25053715_ChIP-Seq_YYC3_Human1.92250538
26RXR_22158963_ChIP-Seq_LIVER_Mouse1.91442155
27SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.90798034
28GATA1_22025678_ChIP-Seq_K562_Human1.88841170
29BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.87067342
30CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.84844061
31PPAR_26484153_Chip-Seq_NCI-H1993_Human1.83290160
32CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.77694666
33THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.74004904
34LXR_22292898_ChIP-Seq_THP-1_Human1.69309503
35TRIM28_21343339_ChIP-Seq_HEK293_Human1.68282215
36EGR1_23403033_ChIP-Seq_LIVER_Mouse1.68098930
37MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.65868868
38ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.55678056
39CLOCK_20551151_ChIP-Seq_293T_Human1.55094882
40IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.52694359
41RUNX1_27514584_Chip-Seq_MCF-7_Human1.52447423
42ZNF263_19887448_ChIP-Seq_K562_Human1.52382448
43GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.49414750
44PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.43867841
45RACK7_27058665_Chip-Seq_MCF-7_Human1.43438348
46NANOG_20526341_ChIP-Seq_ESCs_Human1.40030045
47FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.39173584
48KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.38102621
49NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.37285028
50KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.33541932
51RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.31630742
52HNF4A_19822575_ChIP-Seq_HepG2_Human1.31558576
53ATF3_27146783_Chip-Seq_COLON_Human1.31502516
54ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.29479158
55KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.25737040
56NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.24847722
57SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.21464808
58TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.18357761
59GATA1_19941826_ChIP-Seq_K562_Human1.14310869
60SALL4_18804426_ChIP-ChIP_XEN_Mouse1.14258958
61PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.12995421
62PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.11256949
63ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.11128064
64TET1_21451524_ChIP-Seq_MESCs_Mouse1.10631548
65POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.10457749
66EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.09736298
67FOXM1_23109430_ChIP-Seq_U2OS_Human1.08381546
68FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.08329470
69IKZF1_21737484_ChIP-ChIP_HCT116_Human1.07833850
70RARG_19884340_ChIP-ChIP_MEFs_Mouse1.07745458
71EGR1_19032775_ChIP-ChIP_M12_Human1.06416600
72SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.03966272
73BCL6_27268052_Chip-Seq_Bcells_Human1.03039773
74GATA3_24758297_ChIP-Seq_MCF-7_Human1.02638391
75VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.02577680
76* FOXA1_25552417_ChIP-Seq_VCAP_Human1.02400360
77ESR1_21235772_ChIP-Seq_MCF-7_Human1.01613121
78OCT4_18692474_ChIP-Seq_MEFs_Mouse1.01170474
79CEBPB_22108803_ChIP-Seq_LS180_Human1.00965339
80SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.00661340
81SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.00601019
82SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.99548293
83SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.99548293
84SA1_27219007_Chip-Seq_Bcells_Human0.98885764
85DROSHA_22980978_ChIP-Seq_HELA_Human0.97003479
86CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.96869411
87FOXM1_26456572_ChIP-Seq_MCF-7_Human0.94649348
88RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.93714831
89JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.90371260
90* AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.89599568
91ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.87845248
92ESR2_21235772_ChIP-Seq_MCF-7_Human0.87222387
93GATA2_22383799_ChIP-Seq_G1ME_Mouse0.86591307
94TCF7L2_21901280_ChIP-Seq_H4IIE_Rat0.86584352
95CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.86185291
96TP63_22573176_ChIP-Seq_HFKS_Human0.86072325
97GATA1_22383799_ChIP-Seq_G1ME_Mouse0.85777565
98TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.85465022
99* CTCF_27219007_Chip-Seq_Bcells_Human0.84853098
100TAF2_19829295_ChIP-Seq_ESCs_Human0.83419936
101P63_26484246_Chip-Seq_KERATINOCYTES_Human0.83419777
102DNAJC2_21179169_ChIP-ChIP_NT2_Human0.83139508
103UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.83131014
104BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.82426244
105TCF3_18692474_ChIP-Seq_MEFs_Mouse0.82396597
106SMC1_22415368_ChIP-Seq_MEFs_Mouse0.82191110
107STAT3_20064451_ChIP-Seq_CD4+T_Mouse0.82140750
108SOX2_22085726_ChIP-Seq_NPCs_Mouse0.81588385
109ELF5_23300383_ChIP-Seq_T47D_Human0.80871016
110GATA2_19941826_ChIP-Seq_K562_Human0.80283364
111ESR1_20079471_ChIP-ChIP_T-47D_Human0.79834090
112CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.79811060
113NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.79023176
114ETS1_21867929_ChIP-Seq_TH2_Mouse0.78733305
115FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.78293093
116TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.77537360
117SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.76927921
118JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse0.76234773
119* FOXO3_23340844_ChIP-Seq_DLD1_Human0.74724212
120FOXA2_19822575_ChIP-Seq_HepG2_Human0.74682087
121* KAP1_22055183_ChIP-Seq_ESCs_Mouse0.74181417
122CDX2_22108803_ChIP-Seq_LS180_Human0.73853129
123ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.71927655
124BCOR_27268052_Chip-Seq_Bcells_Human0.71340640
125SOX11_23321250_ChIP-ChIP_Z138-A519-JVM2_Human0.71151955
126EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.70709731
127RAD21_21589869_ChIP-Seq_MESCs_Mouse0.70404598
128* NANOG_18692474_ChIP-Seq_MEFs_Mouse0.70027815
129* FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.69905271
130CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.68758122
131EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.67921360
132CREB1_26743006_Chip-Seq_LNCaP_Human0.67901400
133CTCF_18555785_ChIP-Seq_MESCs_Mouse0.67277986

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010234_abnormal_vibrissa_follicle7.28545973
2MP0003283_abnormal_digestive_organ5.71749300
3MP0005360_urolithiasis5.48172946
4MP0000462_abnormal_digestive_system4.65327112
5MP0001666_abnormal_nutrient_absorption4.59479612
6MP0005085_abnormal_gallbladder_physiolo3.20585965
7MP0003866_abnormal_defecation2.97564279
8MP0004264_abnormal_extraembryonic_tissu2.83936741
9MP0009379_abnormal_foot_pigmentation2.71853457
10MP0008004_abnormal_stomach_pH2.68057186
11MP0002822_catalepsy2.65138375
12MP0005381_digestive/alimentary_phenotyp2.59030550
13MP0002139_abnormal_hepatobiliary_system2.55791572
14MP0000490_abnormal_crypts_of2.54541792
15MP0001873_stomach_inflammation2.52876340
16MP0010155_abnormal_intestine_physiology2.49115346
17MP0001663_abnormal_digestive_system2.42082537
18MP0008875_abnormal_xenobiotic_pharmacok2.40839928
19MP0003315_abnormal_perineum_morphology2.39781221
20MP0009053_abnormal_anal_canal2.34632679
21MP0005409_darkened_coat_color2.23795114
22MP0003252_abnormal_bile_duct2.19454260
23MP0000477_abnormal_intestine_morphology2.18592082
24MP0002234_abnormal_pharynx_morphology2.16751094
25MP0005377_hearing/vestibular/ear_phenot2.15760235
26MP0003878_abnormal_ear_physiology2.15760235
27MP0004019_abnormal_vitamin_homeostasis2.03138894
28MP0005084_abnormal_gallbladder_morpholo1.98445634
29MP0005365_abnormal_bile_salt1.97378927
30MP0000537_abnormal_urethra_morphology1.95552228
31MP0001664_abnormal_digestion1.90174181
32MP0003300_gastrointestinal_ulcer1.72886151
33MP0000613_abnormal_salivary_gland1.58384820
34MP0005670_abnormal_white_adipose1.52320174
35MP0010329_abnormal_lipoprotein_level1.45401877
36MP0009840_abnormal_foam_cell1.45069859
37MP0002132_abnormal_respiratory_system1.39259548
38MP0002796_impaired_skin_barrier1.37965088
39MP0001764_abnormal_homeostasis1.32500007
40MP0002876_abnormal_thyroid_physiology1.31040352
41MP0010678_abnormal_skin_adnexa1.26691422
42MP0001765_abnormal_ion_homeostasis1.24516389
43MP0004782_abnormal_surfactant_physiolog1.23264442
44MP0002098_abnormal_vibrissa_morphology1.22541639
45MP0003123_paternal_imprinting1.22306006
46MP0001188_hyperpigmentation1.21427673
47MP0004043_abnormal_pH_regulation1.20883738
48MP0004858_abnormal_nervous_system1.18658367
49MP0010352_gastrointestinal_tract_polyps1.15067691
50MP0000538_abnormal_urinary_bladder1.14469269
51MP0000470_abnormal_stomach_morphology1.12808863
52MP0009643_abnormal_urine_homeostasis1.12511525
53MP0003806_abnormal_nucleotide_metabolis1.11681860
54MP0003705_abnormal_hypodermis_morpholog1.09528595
55MP0008872_abnormal_physiological_respon1.09098311
56MP0002277_abnormal_respiratory_mucosa1.04648058
57MP0002166_altered_tumor_susceptibility1.03236134
58MP0005636_abnormal_mineral_homeostasis1.00068284
59MP0000230_abnormal_systemic_arterial0.98712571
60MP0006054_spinal_hemorrhage0.96297955
61MP0000762_abnormal_tongue_morphology0.94318452
62MP0001485_abnormal_pinna_reflex0.92985818
63MP0004947_skin_inflammation0.90697043
64MP0004270_analgesia0.90488934
65MP0003453_abnormal_keratinocyte_physiol0.90011535
66MP0003941_abnormal_skin_development0.89688492
67MP0003868_abnormal_feces_composition0.89634566
68MP0001756_abnormal_urination0.87674489
69MP0005319_abnormal_enzyme/_coenzyme0.87083720
70MP0002971_abnormal_brown_adipose0.85089093
71MP0005166_decreased_susceptibility_to0.84709447
72MP0000566_synostosis0.83104845
73MP0005451_abnormal_body_composition0.82659207
74MP0005584_abnormal_enzyme/coenzyme_acti0.81548835
75MP0003693_abnormal_embryo_hatching0.81319306
76MP0003045_fibrosis0.81069604
77MP0005448_abnormal_energy_balance0.80555582
78MP0000678_abnormal_parathyroid_gland0.79911212
79MP0002009_preneoplasia0.79211732
80MP0004484_altered_response_of0.77555745
81MP0001845_abnormal_inflammatory_respons0.77072375
82MP0009115_abnormal_fat_cell0.73428985
83MP0003566_abnormal_cell_adhesion0.72141990
84MP0009642_abnormal_blood_homeostasis0.72008636
85MP0002006_tumorigenesis0.71631862
86MP0003718_maternal_effect0.71532795
87MP0000465_gastrointestinal_hemorrhage0.69568488
88MP0005666_abnormal_adipose_tissue0.68291380
89MP0000467_abnormal_esophagus_morphology0.67660827
90MP0005058_abnormal_lysosome_morphology0.67471111
91MP0005310_abnormal_salivary_gland0.67258587
92MP0005501_abnormal_skin_physiology0.66725215
93MP0003183_abnormal_peptide_metabolism0.66192303
94MP0002896_abnormal_bone_mineralization0.65013305
95MP0005535_abnormal_body_temperature0.64330501
96MP0004147_increased_porphyrin_level0.63938981
97MP0005167_abnormal_blood-brain_barrier0.63487335
98MP0009785_altered_susceptibility_to0.62402343
99MP0008469_abnormal_protein_level0.61426179
100MP0003787_abnormal_imprinting0.61196781
101MP0003953_abnormal_hormone_level0.61189568
102MP0003303_peritoneal_inflammation0.60619831
103MP0005332_abnormal_amino_acid0.60437338
104MP0002909_abnormal_adrenal_gland0.59240138
105MP0001216_abnormal_epidermal_layer0.58391574
106MP0009384_cardiac_valve_regurgitation0.56437935
107MP0000604_amyloidosis0.56393402
108MP0002118_abnormal_lipid_homeostasis0.56136941
109MP0002136_abnormal_kidney_physiology0.55751056
110MP0002078_abnormal_glucose_homeostasis0.54642196
111MP0002396_abnormal_hematopoietic_system0.53900654
112MP0002138_abnormal_hepatobiliary_system0.53492969
113MP0009333_abnormal_splenocyte_physiolog0.52319014
114MP0003329_amyloid_beta_deposits0.51775486
115MP0003879_abnormal_hair_cell0.51038855
116MP0005025_abnormal_response_to0.49917290
117MP0003724_increased_susceptibility_to0.49828687
118MP0000249_abnormal_blood_vessel0.48641174
119MP0003119_abnormal_digestive_system0.46341866
120MP0002254_reproductive_system_inflammat0.45671235
121MP0000609_abnormal_liver_physiology0.44571911
122MP0002089_abnormal_postnatal_growth/wei0.44189972
123MP0010386_abnormal_urinary_bladder0.43826373
124MP0005334_abnormal_fat_pad0.43120048
125MP0001881_abnormal_mammary_gland0.42894246
126MP0002282_abnormal_trachea_morphology0.42770393
127MP0002928_abnormal_bile_duct0.42601059
128MP0000049_abnormal_middle_ear0.42506744
129MP0004215_abnormal_myocardial_fiber0.41831818
130MP0004957_abnormal_blastocyst_morpholog0.41511776
131MP0001501_abnormal_sleep_pattern0.41198410
132MP0002060_abnormal_skin_morphology0.40536576
133MP0000377_abnormal_hair_follicle0.40304430
134MP0002932_abnormal_joint_morphology0.40165031
135MP0000163_abnormal_cartilage_morphology0.39501705
136MP0003191_abnormal_cellular_cholesterol0.35890237
137MP0004272_abnormal_basement_membrane0.35256037
138MP0001849_ear_inflammation0.34691928

Predicted human phenotypes

RankGene SetZ-score
1Posterior subcapsular cataract (HP:0007787)6.46871894
2Ileus (HP:0002595)6.17072430
3Abnormality of proline metabolism (HP:0010907)5.98931353
4Hydroxyprolinuria (HP:0003080)5.98931353
5Hyperactive renin-angiotensin system (HP:0000841)5.84220385
6Flat acetabular roof (HP:0003180)5.81270265
7Decreased circulating renin level (HP:0003351)5.04825081
8Abnormality of the distal phalanx of the thumb (HP:0009617)4.87142567
9Neonatal short-limb short stature (HP:0008921)4.65221308
10Symphalangism affecting the phalanges of the hand (HP:0009773)4.47113381
11Pustule (HP:0200039)4.44934454
12Cupped ribs (HP:0000887)4.44074882
13Abnormality of renin-angiotensin system (HP:0000847)4.43355083
14Abnormality of the 1st metacarpal (HP:0010009)4.19670120
15Ventricular fibrillation (HP:0001663)4.02573164
16Alkalosis (HP:0001948)3.98042125
17Flat capital femoral epiphysis (HP:0003370)3.87798232
18Flattened epiphyses (HP:0003071)3.76641658
19Subcapsular cataract (HP:0000523)3.73780010
20Large earlobe (HP:0009748)3.70400102
21Right ventricular cardiomyopathy (HP:0011663)3.66440139
22Biliary tract neoplasm (HP:0100574)3.62463122
23Abnormality of monocarboxylic acid metabolism (HP:0010996)3.61467611
24Systemic lupus erythematosus (HP:0002725)3.61451121
25Confusion (HP:0001289)3.59299737
26Abnormality of vitamin metabolism (HP:0100508)3.56492598
27Abnormality of carpal bone ossification (HP:0006257)3.54478244
28Abdominal distention (HP:0003270)3.42873973
29Aplasia/Hypoplasia involving the femoral head and neck (HP:0009108)3.39800563
30Conjugated hyperbilirubinemia (HP:0002908)3.36297571
31Ridged nail (HP:0001807)3.33120244
32Abnormal biliary tract morphology (HP:0012440)3.29940006
33Congenital sensorineural hearing impairment (HP:0008527)3.29848114
34Spinal cord compression (HP:0002176)3.29689609
35Irregular epiphyses (HP:0010582)3.26595904
36Pigmentary retinal degeneration (HP:0001146)3.23999136
37Breech presentation (HP:0001623)3.21937599
38Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)3.16158363
39Hyperglycinuria (HP:0003108)3.14675104
40Hemorrhage of the eye (HP:0011885)3.13834531
41Proximal tubulopathy (HP:0000114)3.10320596
42Vertebral hypoplasia (HP:0008417)3.06563329
43Aplasia/Hypoplasia of the vertebrae (HP:0008515)3.06563329
44Abnormal cartilage morphology (HP:0002763)2.99988273
45Abnormality of the proximal phalanges of the hand (HP:0009834)2.96878409
46Xanthomatosis (HP:0000991)2.96870896
47Nausea (HP:0002018)2.96836749
48Malnutrition (HP:0004395)2.95847384
49Abnormal tarsal ossification (HP:0008369)2.95729811
50Abnormality of the phalanges of the hallux (HP:0010057)2.93761941
51Short phalanx of the thumb (HP:0009660)2.90588354
52Woolly hair (HP:0002224)2.87934770
53Abnormality of glutamine family amino acid metabolism (HP:0010902)2.87282707
54Hyperparathyroidism (HP:0000843)2.86560772
55Increased hepatocellular lipid droplets (HP:0006565)2.84340452
56Lipid accumulation in hepatocytes (HP:0006561)2.83325557
57Nephrolithiasis (HP:0000787)2.81544579
58Hyperaldosteronism (HP:0000859)2.81201665
59Visceral angiomatosis (HP:0100761)2.78759270
60Fragile nails (HP:0001808)2.76952391
61Abnormality of serine family amino acid metabolism (HP:0010894)2.71859591
62Abnormality of glycine metabolism (HP:0010895)2.71859591
63Neoplasm of the rectum (HP:0100743)2.69243531
64Vertebral clefting (HP:0008428)2.69054038
65Breast hypoplasia (HP:0003187)2.66169453
66Acanthocytosis (HP:0001927)2.64619815
67Abnormal ossification of hand bones (HP:0005921)2.64294806
68Hypolipoproteinemia (HP:0010981)2.63566476
69Hyperammonemia (HP:0001987)2.63023137
70Widely patent fontanelles and sutures (HP:0004492)2.62329374
71Abnormal vertebral ossification (HP:0100569)2.61827402
72Aplasia/hypoplasia of the femur (HP:0005613)2.61281959
73Short middle phalanx of finger (HP:0005819)2.61124338
74Abnormal hand bone ossification (HP:0010660)2.60959555
75Cheilitis (HP:0100825)2.59980703
76Hypophosphatemia (HP:0002148)2.59199331
77Hyperphosphaturia (HP:0003109)2.58819853
78Hypotension (HP:0002615)2.57456457
79Hyperuricemia (HP:0002149)2.54903477
80Increased purine levels (HP:0004368)2.54903477
81Hemangiomatosis (HP:0007461)2.54403854
82Glycosuria (HP:0003076)2.50921976
83Abnormality of urine glucose concentration (HP:0011016)2.50921976
84Hypobetalipoproteinemia (HP:0003563)2.50114574
85Hypokalemia (HP:0002900)2.48823475
86Micronodular cirrhosis (HP:0001413)2.48007136
87Potter facies (HP:0002009)2.47496105
88Facial shape deformation (HP:0011334)2.47496105
89Chronic diarrhea (HP:0002028)2.47371909
90Symptomatic seizures (HP:0011145)2.43608254
91Abnormal hemoglobin (HP:0011902)2.43600414
92Acute encephalopathy (HP:0006846)2.43362189
93Steatorrhea (HP:0002570)2.42841847
94Neoplasm of the small intestine (HP:0100833)2.42271572
95Megaloblastic anemia (HP:0001889)2.41966040
96Increased intramyocellular lipid droplets (HP:0012240)2.41927212
97Abnormality of the 2nd finger (HP:0004100)2.39198833
98Enlarged epiphyses (HP:0010580)2.37943733
99Cone-rod dystrophy (HP:0000548)2.36711216
100Delayed epiphyseal ossification (HP:0002663)2.35910806
101Focal segmental glomerulosclerosis (HP:0000097)2.34807481
102Mitochondrial inheritance (HP:0001427)2.34329019
103Increased muscle lipid content (HP:0009058)2.33473207
104Hypoplastic ilia (HP:0000946)2.32210522
105Alopecia of scalp (HP:0002293)2.31447648
106Fat malabsorption (HP:0002630)2.29770056
107Hyperphosphatemia (HP:0002905)2.29080609
108Abnormality of the vitamin B12 metabolism (HP:0004341)2.28904328
109Thin bony cortex (HP:0002753)2.28885162
110Hip contracture (HP:0003273)2.27334916
111Abnormality of potassium homeostasis (HP:0011042)2.27317619
112Hyponatremia (HP:0002902)2.26133384
113Aplasia/Hypoplasia of the phalanges of the thumb (HP:0009658)2.25956500
114Renal tubular acidosis (HP:0001947)2.25564330
115Abnormality of the middle phalanges of the toes (HP:0010183)2.20073451
116Short tibia (HP:0005736)2.18911061
117Abnormality of dicarboxylic acid metabolism (HP:0010995)2.18323555
118Dicarboxylic aciduria (HP:0003215)2.18323555
119Abnormality of purine metabolism (HP:0004352)2.18221345
120Progressive macrocephaly (HP:0004481)2.17959556
121Abnormal urine phosphate concentration (HP:0012599)2.17622227
122Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.17065700
123Absent phalangeal crease (HP:0006109)2.16636897
124Gout (HP:0001997)2.13256566
125Wide cranial sutures (HP:0010537)2.13099233
126Glomerulonephritis (HP:0000099)2.12827380
127Late onset (HP:0003584)2.12678094
128Gastrointestinal dysmotility (HP:0002579)2.12151337
129Abnormality of vitamin B metabolism (HP:0004340)2.11713689
130Protuberant abdomen (HP:0001538)2.11364937
131Tracheal stenosis (HP:0002777)2.09858226
132Eczematoid dermatitis (HP:0000976)2.09659054
133Fragile skin (HP:0001030)2.07708657
134Pterygium (HP:0001059)2.07167691
135Abnormality of the costochondral junction (HP:0000919)2.07111115
136Abnormality of chloride homeostasis (HP:0011422)2.06852121
137Metabolic alkalosis (HP:0200114)2.06025521
138Acute necrotizing encephalopathy (HP:0006965)2.05664946
139Pili torti (HP:0003777)2.05470290
140Abnormality of small intestinal villus morphology (HP:0011472)2.05094842
141Villous atrophy (HP:0011473)2.05094842
142Abnormality of magnesium homeostasis (HP:0004921)2.04689368
143Metabolic acidosis (HP:0001942)2.04116355
144Complement deficiency (HP:0004431)2.03840396
145Hoarse voice (HP:0001609)2.03057710
146Hypoglycemic coma (HP:0001325)2.02933512
147Abnormality of nucleobase metabolism (HP:0010932)2.02561935
148Exertional dyspnea (HP:0002875)2.02525333
149Abnormal mitochondria in muscle tissue (HP:0008316)2.02049935
150Ankyloglossia (HP:0010296)2.01899451
151Subacute progressive viral hepatitis (HP:0006572)2.01236879
152Abnormality of aspartate family amino acid metabolism (HP:0010899)2.00065169
153Growth hormone excess (HP:0000845)2.00024083
154Rectal prolapse (HP:0002035)1.99376644
155Cerebral palsy (HP:0100021)1.98821779
156Abnormality of the level of lipoprotein cholesterol (HP:0010979)1.98539099
157Intrahepatic cholestasis (HP:0001406)1.98256645
158Abnormality of complement system (HP:0005339)1.97766514
159Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)1.97707952
160Dehydration (HP:0001944)1.95125122
161Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.89394825
162Epidermoid cyst (HP:0200040)1.86987534
163Abnormality of alkaline phosphatase activity (HP:0004379)1.84404810
164Abnormal enzyme/coenzyme activity (HP:0012379)1.82623751
165Nephritis (HP:0000123)1.81632763

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ACVR1B7.29204658
2LMTK24.70668310
3EPHB24.58981354
4ERN13.91037562
5FRK3.84625119
6PRKG22.95713559
7PIK3CA2.48090418
8MST42.46248791
9FGFR42.40566433
10RIPK12.29489378
11MST1R2.03213153
12TAOK311.4014445
13MAP2K21.96052676
14NME11.95407260
15NUAK11.94027618
16TTK1.79197135
17GRK61.77401957
18PBK1.77383365
19PDK21.73355960
20FGFR31.47756526
21TAOK11.47220988
22MYLK1.42964591
23EIF2AK11.30557141
24TYK21.27332882
25STK241.26416514
26PTK61.26251706
27MAP3K21.22448744
28KSR21.21728318
29TESK11.18718485
30PRPF4B1.16958932
31MAP2K61.14420323
32NEK21.10118198
33EPHA31.03991589
34AURKB1.03449687
35MAP3K91.03198685
36MAP4K10.96924763
37EPHA20.94625532
38TRIB30.92224735
39EPHB10.90777524
40SMG10.90687027
41TNIK0.90354386
42ERBB20.86968249
43PDK10.75544892
44PTK20.70846396
45DDR20.68887177
46PDGFRA0.68231478
47DYRK1B0.67517363
48TESK20.67444387
49MATK0.67028456
50EPHA40.64799771
51IRAK30.63331202
52NLK0.62412089
53PRKCI0.60027316
54STK390.58828133
55MAP2K10.58747279
56CASK0.57574543
57RET0.55626732
58RIPK40.55490989
59CAMK2D0.54931090
60MAP3K110.54417023
61PRKAA20.54004503
62MAP3K120.53958905
63MAP3K80.53011334
64MAP3K130.52755541
65MAP3K140.50916105
66PIK3CG0.50910630
67ARAF0.48413933
68CDK190.47154367
69GRK10.46857338
70PAK40.45928268
71ILK0.44084207
72PRKCZ0.43575116
73PAK10.43400259
74ICK0.43137401
75LIMK10.42266723
76MAP3K100.40421593
77CAMK2B0.39820253
78AKT30.39501587
79ABL20.37913486
80PASK0.37795338
81PIM10.36756598
82FYN0.36072292
83PKN20.35607579
84PLK10.33486197
85TBK10.33468247
86CAMK2G0.33423285
87IRAK10.32054381
88BMPR20.32051614
89PRKCA0.32000376
90JAK10.31188546
91OXSR10.30831919
92JAK20.30417339
93STK110.29778445
94MET0.29363135
95MAPK110.29225802
96CSF1R0.27578727
97TLK10.26688735
98MAP3K10.26443982
99EEF2K0.26103689
100SRC0.25704465
101PRKCD0.25182634
102BRAF0.24373467
103MAPKAPK50.22845913
104DAPK20.21253345
105MAPKAPK20.20622584
106STK30.20175245
107YES10.19571699
108CHEK20.19281037
109NEK60.18576159
110LYN0.18033875
111CDK60.17227782
112MELK0.15792588
113RPS6KA20.15278705
114ROCK10.14842033
115IGF1R0.14742079
116IKBKE0.14451337
117PRKAA10.13770517
118MAP3K30.13761464
119KSR10.13630586
120EIF2AK20.13086052
121ALK0.12785341
122CDC42BPA0.12692481
123PRKCQ0.12517402
124PRKACG0.12462849
125FER0.12443936
126WNK40.12398860
127RPS6KB20.12201207
128ITK0.10707222
129CDK150.10022431
130CSK0.09503863
131CDK11A0.09321816
132NEK10.08757684
133LATS10.08172914
134PDPK10.07916682
135CDK180.07706151
136BMX0.07649918
137PRKD20.07241945
138AKT20.06501641
139STK100.06307579
140PRKCB0.06101303
141CSNK1E0.05580927
142CDK70.05405708
143CSNK1A10.05003684

Predicted pathways (KEGG)

RankGene SetZ-score
1Sulfur metabolism_Homo sapiens_hsa009205.09512636
2Fat digestion and absorption_Homo sapiens_hsa049754.09738049
3Butirosin and neomycin biosynthesis_Homo sapiens_hsa005244.03405592
4Mineral absorption_Homo sapiens_hsa049783.60813736
5Maturity onset diabetes of the young_Homo sapiens_hsa049502.91148987
6Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.86811069
7Renin-angiotensin system_Homo sapiens_hsa046142.73889971
8Oxidative phosphorylation_Homo sapiens_hsa001902.38453638
9Bile secretion_Homo sapiens_hsa049762.33939278
10Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.24454221
11Histidine metabolism_Homo sapiens_hsa003402.06511679
12Galactose metabolism_Homo sapiens_hsa000522.03517137
13Parkinsons disease_Homo sapiens_hsa050122.03203238
14Vitamin digestion and absorption_Homo sapiens_hsa049771.99077001
15Folate biosynthesis_Homo sapiens_hsa007901.95968383
16Carbohydrate digestion and absorption_Homo sapiens_hsa049731.93589544
17Fructose and mannose metabolism_Homo sapiens_hsa000511.90248924
18Starch and sucrose metabolism_Homo sapiens_hsa005001.76995757
19Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.76421520
20Alzheimers disease_Homo sapiens_hsa050101.73812929
21Protein digestion and absorption_Homo sapiens_hsa049741.62526978
22Butanoate metabolism_Homo sapiens_hsa006501.59149140
23Pentose and glucuronate interconversions_Homo sapiens_hsa000401.50802355
24Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.48822100
25Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.44175805
26Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.43613689
27Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.43205573
28Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.41263910
29Tryptophan metabolism_Homo sapiens_hsa003801.36894714
30Pentose phosphate pathway_Homo sapiens_hsa000301.33228196
31Huntingtons disease_Homo sapiens_hsa050161.30095244
32Glutathione metabolism_Homo sapiens_hsa004801.29500968
33Caffeine metabolism_Homo sapiens_hsa002321.28902511
342-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.28233916
35Nitrogen metabolism_Homo sapiens_hsa009101.26599074
36Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.25571791
37Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.20113164
38Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.17640550
39Drug metabolism - other enzymes_Homo sapiens_hsa009831.16055869
40Fatty acid degradation_Homo sapiens_hsa000711.14740212
41Tight junction_Homo sapiens_hsa045301.10636835
42Cardiac muscle contraction_Homo sapiens_hsa042601.10434874
43Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.98931198
44PPAR signaling pathway_Homo sapiens_hsa033200.98039475
45Arginine and proline metabolism_Homo sapiens_hsa003300.96832481
46Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.93355090
47Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.91751723
48Leukocyte transendothelial migration_Homo sapiens_hsa046700.90381659
49Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.83183014
50Chemical carcinogenesis_Homo sapiens_hsa052040.82691029
51Sulfur relay system_Homo sapiens_hsa041220.80758832
52Ribosome_Homo sapiens_hsa030100.79591752
53Cyanoamino acid metabolism_Homo sapiens_hsa004600.79559432
54Ether lipid metabolism_Homo sapiens_hsa005650.79546581
55Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.79538453
56Other glycan degradation_Homo sapiens_hsa005110.78924240
57Carbon metabolism_Homo sapiens_hsa012000.77775656
58Asthma_Homo sapiens_hsa053100.77732907
59Steroid biosynthesis_Homo sapiens_hsa001000.76947075
60Pancreatic secretion_Homo sapiens_hsa049720.76227593
61Glycerolipid metabolism_Homo sapiens_hsa005610.75343956
62Steroid hormone biosynthesis_Homo sapiens_hsa001400.71423291
63Hepatitis C_Homo sapiens_hsa051600.70458515
64Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.67095972
65Salivary secretion_Homo sapiens_hsa049700.66921429
66Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.66105566
67Pyruvate metabolism_Homo sapiens_hsa006200.63334280
68Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.60307477
69Thyroid hormone synthesis_Homo sapiens_hsa049180.59893753
70Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.55139970
71Gastric acid secretion_Homo sapiens_hsa049710.55093466
72Allograft rejection_Homo sapiens_hsa053300.53859650
73Propanoate metabolism_Homo sapiens_hsa006400.53095148
74Sphingolipid metabolism_Homo sapiens_hsa006000.52695707
75Staphylococcus aureus infection_Homo sapiens_hsa051500.52268332
76Peroxisome_Homo sapiens_hsa041460.50342962
77Arginine biosynthesis_Homo sapiens_hsa002200.50288328
78Fatty acid biosynthesis_Homo sapiens_hsa000610.49796462
79Autoimmune thyroid disease_Homo sapiens_hsa053200.49068973
80beta-Alanine metabolism_Homo sapiens_hsa004100.47896993
81Intestinal immune network for IgA production_Homo sapiens_hsa046720.47392310
82Metabolic pathways_Homo sapiens_hsa011000.46661168
83Tyrosine metabolism_Homo sapiens_hsa003500.46524027
84Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.46026586
85Type II diabetes mellitus_Homo sapiens_hsa049300.45441480
86Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.45386143
87Primary bile acid biosynthesis_Homo sapiens_hsa001200.45181769
88Renin secretion_Homo sapiens_hsa049240.45047440
89Graft-versus-host disease_Homo sapiens_hsa053320.44808462
90Retinol metabolism_Homo sapiens_hsa008300.44789351
91Type I diabetes mellitus_Homo sapiens_hsa049400.40899507
92Salmonella infection_Homo sapiens_hsa051320.36727462
93Insulin resistance_Homo sapiens_hsa049310.36105623
94alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.35366465
95Glycerophospholipid metabolism_Homo sapiens_hsa005640.33638350
96ABC transporters_Homo sapiens_hsa020100.33222158
97Bladder cancer_Homo sapiens_hsa052190.31303228
98African trypanosomiasis_Homo sapiens_hsa051430.31261697
99Endometrial cancer_Homo sapiens_hsa052130.29657906
100Adipocytokine signaling pathway_Homo sapiens_hsa049200.27838693
101Linoleic acid metabolism_Homo sapiens_hsa005910.24639210
102Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.24606611
103TNF signaling pathway_Homo sapiens_hsa046680.22966765
104Vibrio cholerae infection_Homo sapiens_hsa051100.22934850
105Arachidonic acid metabolism_Homo sapiens_hsa005900.22301546
106Phenylalanine metabolism_Homo sapiens_hsa003600.21178665
107Choline metabolism in cancer_Homo sapiens_hsa052310.18714336
108Glucagon signaling pathway_Homo sapiens_hsa049220.17488147
109Antigen processing and presentation_Homo sapiens_hsa046120.17396483
110Biosynthesis of amino acids_Homo sapiens_hsa012300.17217223
111Thyroid cancer_Homo sapiens_hsa052160.15836368
112Fatty acid elongation_Homo sapiens_hsa000620.15829409
113Cocaine addiction_Homo sapiens_hsa050300.15259196
114Gap junction_Homo sapiens_hsa045400.14923420
115Complement and coagulation cascades_Homo sapiens_hsa046100.14437248
116Fatty acid metabolism_Homo sapiens_hsa012120.12729946
117Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.12141908
118NOD-like receptor signaling pathway_Homo sapiens_hsa046210.12131442
119Central carbon metabolism in cancer_Homo sapiens_hsa052300.11802129
120Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.11754270
121Phosphatidylinositol signaling system_Homo sapiens_hsa040700.11385996
122Apoptosis_Homo sapiens_hsa042100.11097306
123VEGF signaling pathway_Homo sapiens_hsa043700.10917797
124Insulin secretion_Homo sapiens_hsa049110.10405414
125Leishmaniasis_Homo sapiens_hsa051400.09971470
126Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.09720481
127Pertussis_Homo sapiens_hsa051330.09310204
128Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.08685338
129Chronic myeloid leukemia_Homo sapiens_hsa052200.07520617
130Amoebiasis_Homo sapiens_hsa051460.06403870
131GnRH signaling pathway_Homo sapiens_hsa049120.05687953
132AMPK signaling pathway_Homo sapiens_hsa041520.03314906
133Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.01234566

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