

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | synaptic vesicle maturation (GO:0016188) | 4.90546411 |
| 2 | regulation of short-term neuronal synaptic plasticity (GO:0048172) | 4.84513711 |
| 3 | positive regulation of calcium ion-dependent exocytosis (GO:0045956) | 4.74784579 |
| 4 | positive regulation of mitochondrial fission (GO:0090141) | 4.69519097 |
| 5 | synaptic vesicle exocytosis (GO:0016079) | 4.58353448 |
| 6 | locomotory exploration behavior (GO:0035641) | 4.43620288 |
| 7 | glutamate secretion (GO:0014047) | 4.39239335 |
| 8 | regulation of synaptic vesicle exocytosis (GO:2000300) | 4.31234312 |
| 9 | vocalization behavior (GO:0071625) | 4.09555470 |
| 10 | positive regulation of excitatory postsynaptic membrane potential (GO:2000463) | 4.08547155 |
| 11 | pyrimidine nucleobase catabolic process (GO:0006208) | 3.95801127 |
| 12 | regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act | 3.83291191 |
| 13 | neuron cell-cell adhesion (GO:0007158) | 3.78755560 |
| 14 | regulation of synaptic vesicle transport (GO:1902803) | 3.78084361 |
| 15 | layer formation in cerebral cortex (GO:0021819) | 3.76457892 |
| 16 | neuronal action potential propagation (GO:0019227) | 3.73847861 |
| 17 | protein localization to synapse (GO:0035418) | 3.71040855 |
| 18 | exploration behavior (GO:0035640) | 3.69332869 |
| 19 | neurotransmitter secretion (GO:0007269) | 3.68052582 |
| 20 | regulation of glutamate receptor signaling pathway (GO:1900449) | 3.66720383 |
| 21 | cellular potassium ion homeostasis (GO:0030007) | 3.65970928 |
| 22 | regulation of neuronal synaptic plasticity (GO:0048168) | 3.52960322 |
| 23 | ionotropic glutamate receptor signaling pathway (GO:0035235) | 3.52937081 |
| 24 | regulation of long-term neuronal synaptic plasticity (GO:0048169) | 3.46470123 |
| 25 | nucleobase catabolic process (GO:0046113) | 3.45239477 |
| 26 | proline transport (GO:0015824) | 3.44983559 |
| 27 | synaptic vesicle docking involved in exocytosis (GO:0016081) | 3.43986851 |
| 28 | regulation of synapse structural plasticity (GO:0051823) | 3.41054800 |
| 29 | gamma-aminobutyric acid transport (GO:0015812) | 3.37535160 |
| 30 | sodium ion export (GO:0071436) | 3.27675393 |
| 31 | glutamate receptor signaling pathway (GO:0007215) | 3.26356117 |
| 32 | neuron recognition (GO:0008038) | 3.25135876 |
| 33 | regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310) | 3.23785787 |
| 34 | activation of protein kinase A activity (GO:0034199) | 3.22858341 |
| 35 | dendritic spine morphogenesis (GO:0060997) | 3.21992050 |
| 36 | protein localization to cilium (GO:0061512) | 3.21940959 |
| 37 | synaptic transmission, glutamatergic (GO:0035249) | 3.18009146 |
| 38 | C4-dicarboxylate transport (GO:0015740) | 3.16445393 |
| 39 | neuron-neuron synaptic transmission (GO:0007270) | 3.15311748 |
| 40 | neurotransmitter transport (GO:0006836) | 3.11490959 |
| 41 | L-serine transport (GO:0015825) | 3.11345993 |
| 42 | glycosphingolipid biosynthetic process (GO:0006688) | 3.10569000 |
| 43 | neurotransmitter-gated ion channel clustering (GO:0072578) | 3.09857389 |
| 44 | innervation (GO:0060384) | 3.08993789 |
| 45 | regulation of mitochondrial fission (GO:0090140) | 3.05695068 |
| 46 | membrane depolarization during cardiac muscle cell action potential (GO:0086012) | 3.04339637 |
| 47 | dendrite morphogenesis (GO:0048813) | 3.03284776 |
| 48 | axonal fasciculation (GO:0007413) | 3.02540915 |
| 49 | positive regulation of potassium ion transmembrane transporter activity (GO:1901018) | 3.02224561 |
| 50 | gamma-aminobutyric acid signaling pathway (GO:0007214) | 3.00377104 |
| 51 | long-term memory (GO:0007616) | 2.99610862 |
| 52 | long-term synaptic potentiation (GO:0060291) | 2.97426777 |
| 53 | transmission of nerve impulse (GO:0019226) | 2.96237832 |
| 54 | vesicle transport along microtubule (GO:0047496) | 2.96185282 |
| 55 | cell communication by electrical coupling involved in cardiac conduction (GO:0086064) | 2.94974472 |
| 56 | regulation of vesicle fusion (GO:0031338) | 2.91646599 |
| 57 | mating behavior (GO:0007617) | 2.89974652 |
| 58 | regulation of excitatory postsynaptic membrane potential (GO:0060079) | 2.89543924 |
| 59 | regulation of synaptic plasticity (GO:0048167) | 2.87096030 |
| 60 | cell communication by electrical coupling (GO:0010644) | 2.86935544 |
| 61 | positive regulation of synaptic transmission, glutamatergic (GO:0051968) | 2.86245266 |
| 62 | glycine transport (GO:0015816) | 2.85998167 |
| 63 | regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:1902235 | 2.85172476 |
| 64 | regulation of synaptic transmission, glutamatergic (GO:0051966) | 2.84256977 |
| 65 | regulation of neurotransmitter levels (GO:0001505) | 2.83804253 |
| 66 | negative regulation of amyloid precursor protein catabolic process (GO:1902992) | 2.82797859 |
| 67 | positive regulation of membrane potential (GO:0045838) | 2.82511816 |
| 68 | positive regulation of synaptic transmission, GABAergic (GO:0032230) | 2.81026062 |
| 69 | regulation of inhibitory postsynaptic membrane potential (GO:0060080) | 2.80440065 |
| 70 | organelle transport along microtubule (GO:0072384) | 2.79612298 |
| 71 | regulation of dendritic spine morphogenesis (GO:0061001) | 2.79427530 |
| 72 | regulation of postsynaptic membrane potential (GO:0060078) | 2.78350373 |
| 73 | regulation of neurotransmitter secretion (GO:0046928) | 2.77591666 |
| 74 | response to auditory stimulus (GO:0010996) | 2.75670352 |
| 75 | neuromuscular process controlling balance (GO:0050885) | 2.73720431 |
| 76 | presynaptic membrane assembly (GO:0097105) | 2.72983199 |
| 77 | negative regulation of synaptic transmission, GABAergic (GO:0032229) | 2.72553936 |
| 78 | synaptic vesicle endocytosis (GO:0048488) | 2.70629629 |
| 79 | establishment of mitochondrion localization (GO:0051654) | 2.70402386 |
| 80 | short-term memory (GO:0007614) | 2.69542167 |
| 81 | negative regulation of synaptic transmission, glutamatergic (GO:0051967) | 2.69471701 |
| 82 | neuronal ion channel clustering (GO:0045161) | 2.67554350 |
| 83 | neuromuscular process controlling posture (GO:0050884) | 2.65737508 |
| 84 | calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339) | 2.65410769 |
| 85 | startle response (GO:0001964) | 2.65165158 |
| 86 | presynaptic membrane organization (GO:0097090) | 2.64031052 |
| 87 | detection of calcium ion (GO:0005513) | 2.62501711 |
| 88 | potassium ion import (GO:0010107) | 2.62260580 |
| 89 | positive regulation of synapse maturation (GO:0090129) | 2.62223133 |
| 90 | synapse assembly (GO:0007416) | 2.60954956 |
| 91 | membrane depolarization during action potential (GO:0086010) | 2.60656518 |
| 92 | potassium ion homeostasis (GO:0055075) | 2.60020877 |
| 93 | establishment of melanosome localization (GO:0032401) | 2.59916307 |
| 94 | cerebellar Purkinje cell layer development (GO:0021680) | 2.59398889 |
| 95 | melanosome transport (GO:0032402) | 2.59340356 |
| 96 | cellular sodium ion homeostasis (GO:0006883) | 2.57810154 |
| 97 | postsynaptic membrane organization (GO:0001941) | 2.57087052 |
| 98 | regulation of neurotransmitter transport (GO:0051588) | 2.56820279 |
| 99 | positive regulation of potassium ion transmembrane transport (GO:1901381) | 2.56804653 |
| 100 | cerebellar granule cell differentiation (GO:0021707) | 2.56145534 |
| 101 | auditory behavior (GO:0031223) | 2.56112036 |
| 102 | regulation of amyloid precursor protein catabolic process (GO:1902991) | 2.54190057 |
| 103 | prepulse inhibition (GO:0060134) | 2.54129146 |
| 104 | synapse organization (GO:0050808) | 2.52128171 |
| 105 | dendritic spine organization (GO:0097061) | 2.52039959 |
| 106 | cerebellar Purkinje cell differentiation (GO:0021702) | 2.51996163 |
| 107 | positive regulation of potassium ion transport (GO:0043268) | 2.51959544 |
| 108 | membrane hyperpolarization (GO:0060081) | 2.51202951 |
| 109 | positive regulation of synaptic transmission (GO:0050806) | 2.50113886 |
| 110 | suckling behavior (GO:0001967) | 2.49707903 |
| 111 | dicarboxylic acid catabolic process (GO:0043649) | 2.49277679 |
| 112 | membrane depolarization (GO:0051899) | 2.49036573 |
| 113 | regulation of calcium ion-dependent exocytosis (GO:0017158) | 2.48953779 |
| 114 | establishment of pigment granule localization (GO:0051905) | 2.47401401 |
| 115 | acidic amino acid transport (GO:0015800) | 2.47313685 |
| 116 | learning (GO:0007612) | 2.46863786 |
| 117 | synaptic transmission (GO:0007268) | 2.46496658 |
| 118 | regulation of respiratory gaseous exchange by neurological system process (GO:0002087) | 2.46469450 |
| 119 | pigment granule transport (GO:0051904) | 2.46282771 |
| 120 | neurotransmitter uptake (GO:0001504) | 2.43139808 |
| 121 | establishment of vesicle localization (GO:0051650) | 2.41281431 |
| 122 | positive regulation of dendritic spine morphogenesis (GO:0061003) | 2.38753185 |
| 123 | glycerophospholipid catabolic process (GO:0046475) | 2.37928244 |
| 124 | serine transport (GO:0032329) | 2.37532011 |
| 125 | endoplasmic reticulum organization (GO:0007029) | 2.37182890 |
| 126 | positive regulation of vesicle fusion (GO:0031340) | 2.32054957 |
| 127 | regulation of Arp2/3 complex-mediated actin nucleation (GO:0034315) | 2.31712096 |
| 128 | regulation of cell communication by electrical coupling (GO:0010649) | 2.30525771 |
| 129 | regulation of glucokinase activity (GO:0033131) | 2.28329128 |
| 130 | regulation of hexokinase activity (GO:1903299) | 2.28329128 |
| 131 | vesicle localization (GO:0051648) | 2.27364934 |
| 132 | dopamine transport (GO:0015872) | 2.26347451 |
| 133 | peroxisome fission (GO:0016559) | 2.26149571 |
| 134 | regulation of dendritic spine development (GO:0060998) | 2.24065609 |
| 135 | negative regulation of cation channel activity (GO:2001258) | 2.21754965 |
| 136 | melanosome localization (GO:0032400) | 2.21496388 |
| 137 | positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316) | 2.21310728 |
| 138 | establishment of synaptic vesicle localization (GO:0097480) | 2.20238010 |
| 139 | synaptic vesicle transport (GO:0048489) | 2.20238010 |
| 140 | positive regulation of synapse assembly (GO:0051965) | 2.19476133 |
| 141 | positive regulation of phosphoprotein phosphatase activity (GO:0032516) | 2.19309189 |
| 142 | L-glutamate transport (GO:0015813) | 2.18203471 |
| 143 | cell communication involved in cardiac conduction (GO:0086065) | 2.17911062 |
| 144 | regulation of cAMP-dependent protein kinase activity (GO:2000479) | 2.16110444 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | EZH2_22144423_ChIP-Seq_EOC_Human | 4.75580910 |
| 2 | GBX2_23144817_ChIP-Seq_PC3_Human | 3.35135631 |
| 3 | SUZ12_18692474_ChIP-Seq_MESCs_Mouse | 2.92249725 |
| 4 | SUZ12_18555785_ChIP-Seq_MESCs_Mouse | 2.90840784 |
| 5 | JARID2_20064375_ChIP-Seq_MESCs_Mouse | 2.68271006 |
| 6 | RNF2_18974828_ChIP-Seq_MESCs_Mouse | 2.46863381 |
| 7 | EZH2_18974828_ChIP-Seq_MESCs_Mouse | 2.46863381 |
| 8 | SUZ12_18974828_ChIP-Seq_MESCs_Mouse | 2.45353550 |
| 9 | MTF2_20144788_ChIP-Seq_MESCs_Mouse | 2.43921916 |
| 10 | SUZ12_20075857_ChIP-Seq_MESCs_Mouse | 2.43004895 |
| 11 | SUZ12_18692474_ChIP-Seq_MEFs_Mouse | 2.40858776 |
| 12 | JARID2_20075857_ChIP-Seq_MESCs_Mouse | 2.39783682 |
| 13 | SUZ12_16625203_ChIP-ChIP_MESCs_Mouse | 2.36861583 |
| 14 | REST_21632747_ChIP-Seq_MESCs_Mouse | 2.29795316 |
| 15 | EZH2_27304074_Chip-Seq_ESCs_Mouse | 2.20976069 |
| 16 | EED_16625203_ChIP-ChIP_MESCs_Mouse | 2.13902860 |
| 17 | DROSHA_22980978_ChIP-Seq_HELA_Human | 2.10413697 |
| 18 | EZH2_27294783_Chip-Seq_ESCs_Mouse | 2.06924571 |
| 19 | SUZ12_27294783_Chip-Seq_ESCs_Mouse | 2.06353789 |
| 20 | RARB_27405468_Chip-Seq_BRAIN_Mouse | 2.05770994 |
| 21 | RNF2_27304074_Chip-Seq_ESCs_Mouse | 1.93947148 |
| 22 | REST_18959480_ChIP-ChIP_MESCs_Mouse | 1.87291969 |
| 23 | FUS_26573619_Chip-Seq_HEK293_Human | 1.85969915 |
| 24 | ZFP322A_24550733_ChIP-Seq_MESCs_Mouse | 1.81434817 |
| 25 | AR_21572438_ChIP-Seq_LNCaP_Human | 1.81427232 |
| 26 | GLI1_17442700_ChIP-ChIP_MESCs_Mouse | 1.78970687 |
| 27 | CTBP2_25329375_ChIP-Seq_LNCAP_Human | 1.75385624 |
| 28 | TAF15_26573619_Chip-Seq_HEK293_Human | 1.71138409 |
| 29 | * MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse | 1.63634107 |
| 30 | CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons | 1.61452960 |
| 31 | SMAD4_21799915_ChIP-Seq_A2780_Human | 1.61435142 |
| 32 | NR4A2_19515692_ChIP-ChIP_MN9D_Mouse | 1.57845565 |
| 33 | * CTBP1_25329375_ChIP-Seq_LNCAP_Human | 1.54233172 |
| 34 | IKZF1_21737484_ChIP-ChIP_HCT116_Human | 1.53337673 |
| 35 | CDX2_19796622_ChIP-Seq_MESCs_Mouse | 1.52218217 |
| 36 | FLI1_27457419_Chip-Seq_LIVER_Mouse | 1.51810419 |
| 37 | NR3C1_23031785_ChIP-Seq_PC12_Mouse | 1.51650069 |
| 38 | ZFP57_27257070_Chip-Seq_ESCs_Mouse | 1.47850012 |
| 39 | PIAS1_25552417_ChIP-Seq_VCAP_Human | 1.46964552 |
| 40 | PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human | 1.46609776 |
| 41 | SMARCD1_25818293_ChIP-Seq_ESCs_Mouse | 1.46153339 |
| 42 | ZNF274_21170338_ChIP-Seq_K562_Hela | 1.45713410 |
| 43 | RNF2_27304074_Chip-Seq_NSC_Mouse | 1.44953713 |
| 44 | NANOG_18555785_Chip-Seq_ESCs_Mouse | 1.44518560 |
| 45 | MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human | 1.44430542 |
| 46 | * SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse | 1.44117661 |
| 47 | OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse | 1.41325083 |
| 48 | P300_19829295_ChIP-Seq_ESCs_Human | 1.40489427 |
| 49 | HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse | 1.39921170 |
| 50 | SMAD2/3_21741376_ChIP-Seq_EPCs_Human | 1.36154973 |
| 51 | CBP_20019798_ChIP-Seq_JUKART_Human | 1.35134294 |
| 52 | IRF4_20064451_ChIP-Seq_CD4+T_Mouse | 1.35134294 |
| 53 | EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse | 1.34963579 |
| 54 | PCGF2_27294783_Chip-Seq_ESCs_Mouse | 1.33885563 |
| 55 | IGF1R_20145208_ChIP-Seq_DFB_Human | 1.33025866 |
| 56 | ERG_21242973_ChIP-ChIP_JURKAT_Human | 1.32880345 |
| 57 | EWS_26573619_Chip-Seq_HEK293_Human | 1.31842558 |
| 58 | SOX2_21211035_ChIP-Seq_LN229_Gbm | 1.31698993 |
| 59 | AR_25329375_ChIP-Seq_VCAP_Human | 1.27641034 |
| 60 | ZNF217_24962896_ChIP-Seq_MCF-7_Human | 1.26726191 |
| 61 | SMAD3_21741376_ChIP-Seq_EPCs_Human | 1.26080514 |
| 62 | TOP2B_26459242_ChIP-Seq_MCF-7_Human | 1.25987030 |
| 63 | P53_22387025_ChIP-Seq_ESCs_Mouse | 1.25574135 |
| 64 | PHC1_16625203_ChIP-ChIP_MESCs_Mouse | 1.24859414 |
| 65 | RNF2_16625203_ChIP-ChIP_MESCs_Mouse | 1.24695287 |
| 66 | * AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human | 1.24235961 |
| 67 | RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse | 1.24222458 |
| 68 | * STAT3_23295773_ChIP-Seq_U87_Human | 1.24150872 |
| 69 | EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse | 1.23272506 |
| 70 | TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse | 1.22399797 |
| 71 | TAL1_26923725_Chip-Seq_HPCs_Mouse | 1.21290546 |
| 72 | FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse | 1.20632802 |
| 73 | POU3F2_20337985_ChIP-ChIP_501MEL_Human | 1.19349722 |
| 74 | FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse | 1.18868355 |
| 75 | SUZ12_27294783_Chip-Seq_NPCs_Mouse | 1.18349647 |
| 76 | KLF5_20875108_ChIP-Seq_MESCs_Mouse | 1.17173099 |
| 77 | WT1_25993318_ChIP-Seq_PODOCYTE_Human | 1.15955381 |
| 78 | CMYC_18555785_Chip-Seq_ESCs_Mouse | 1.15596696 |
| 79 | RING1B_27294783_Chip-Seq_ESCs_Mouse | 1.15499618 |
| 80 | * TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse | 1.14723722 |
| 81 | GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 1.13409100 |
| 82 | ARNT_22903824_ChIP-Seq_MCF-7_Human | 1.12769393 |
| 83 | AR_19668381_ChIP-Seq_PC3_Human | 1.12243819 |
| 84 | WT1_19549856_ChIP-ChIP_CCG9911_Human | 1.11457894 |
| 85 | CBX2_27304074_Chip-Seq_ESCs_Mouse | 1.09157359 |
| 86 | E2F1_18555785_Chip-Seq_ESCs_Mouse | 1.09035218 |
| 87 | ESR1_22446102_ChIP-Seq_UTERUS_Mouse | 1.08714895 |
| 88 | AHR_22903824_ChIP-Seq_MCF-7_Human | 1.08181516 |
| 89 | JUN_21703547_ChIP-Seq_K562_Human | 1.08179907 |
| 90 | KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse | 1.08159355 |
| 91 | PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse | 1.07916269 |
| 92 | BMI1_23680149_ChIP-Seq_NPCS_Mouse | 1.07833625 |
| 93 | EZH2_27294783_Chip-Seq_NPCs_Mouse | 1.07073781 |
| 94 | MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human | 1.06875477 |
| 95 | CEBPD_23245923_ChIP-Seq_MEFs_Mouse | 1.06485945 |
| 96 | TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human | 1.06120579 |
| 97 | NR3C1_21868756_ChIP-Seq_MCF10A_Human | 1.04727045 |
| 98 | SUZ12_18555785_Chip-Seq_ESCs_Mouse | 1.04154661 |
| 99 | TCF4_23295773_ChIP-Seq_U87_Human | 1.03513192 |
| 100 | DNAJC2_21179169_ChIP-ChIP_NT2_Human | 1.03047947 |
| 101 | CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 1.03007445 |
| 102 | TFAP2C_20629094_ChIP-Seq_MCF-7_Human | 1.02841936 |
| 103 | EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse | 1.00663188 |
| 104 | * YAP1_20516196_ChIP-Seq_MESCs_Mouse | 1.00098361 |
| 105 | P53_22127205_ChIP-Seq_FIBROBLAST_Human | 0.99074673 |
| 106 | FLI1_21867929_ChIP-Seq_TH2_Mouse | 0.98514425 |
| 107 | SOX2_18555785_Chip-Seq_ESCs_Mouse | 0.98507399 |
| 108 | NRF2_20460467_ChIP-Seq_MEFs_Mouse | 0.98330519 |
| 109 | NFE2L2_20460467_ChIP-Seq_MEFs_Mouse | 0.98330519 |
| 110 | STAT3_18555785_Chip-Seq_ESCs_Mouse | 0.98043248 |
| 111 | BCAT_22108803_ChIP-Seq_LS180_Human | 0.97789990 |
| 112 | RUNX2_22187159_ChIP-Seq_PCA_Human | 0.97600161 |
| 113 | WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse | 0.97412505 |
| 114 | TP53_16413492_ChIP-PET_HCT116_Human | 0.96953351 |
| 115 | SMAD_19615063_ChIP-ChIP_OVARY_Human | 0.95365248 |
| 116 | * TP53_18474530_ChIP-ChIP_U2OS_Human | 0.95192628 |
| 117 | SMAD4_21741376_ChIP-Seq_HESCs_Human | 0.95140776 |
| 118 | TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 0.94695175 |
| 119 | EP300_21415370_ChIP-Seq_HL-1_Mouse | 0.94169219 |
| 120 | VDR_22108803_ChIP-Seq_LS180_Human | 0.93834893 |
| 121 | RCOR3_21632747_ChIP-Seq_MESCs_Mouse | 0.93694504 |
| 122 | RING1B_27294783_Chip-Seq_NPCs_Mouse | 0.93668852 |
| 123 | UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human | 0.92933038 |
| 124 | BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human | 0.92216177 |
| 125 | PRDM14_20953172_ChIP-Seq_ESCs_Human | 0.91819043 |
| 126 | ESRRB_18555785_ChIP-Seq_MESCs_Mouse | 0.91436392 |
| 127 | SMAD3_21741376_ChIP-Seq_ESCs_Human | 0.89743759 |
| 128 | MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse | 0.89658729 |
| 129 | TCF3_18467660_ChIP-ChIP_MESCs_Mouse | 0.89627908 |
| 130 | ER_23166858_ChIP-Seq_MCF-7_Human | 0.88840000 |
| 131 | RXR_22108803_ChIP-Seq_LS180_Human | 0.87260980 |
| 132 | TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse | 0.85071863 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MP0004859_abnormal_synaptic_plasticity | 5.42718985 |
| 2 | MP0003880_abnormal_central_pattern | 4.04644439 |
| 3 | MP0004270_analgesia | 3.79965597 |
| 4 | MP0003635_abnormal_synaptic_transmissio | 3.64579692 |
| 5 | MP0009745_abnormal_behavioral_response | 2.96193536 |
| 6 | MP0002063_abnormal_learning/memory/cond | 2.92607895 |
| 7 | MP0002064_seizures | 2.80038085 |
| 8 | MP0001968_abnormal_touch/_nociception | 2.79903353 |
| 9 | MP0009046_muscle_twitch | 2.63481991 |
| 10 | MP0002734_abnormal_mechanical_nocicepti | 2.61024964 |
| 11 | MP0003329_amyloid_beta_deposits | 2.46174451 |
| 12 | MP0002572_abnormal_emotion/affect_behav | 2.46020639 |
| 13 | MP0002272_abnormal_nervous_system | 2.40363076 |
| 14 | MP0009780_abnormal_chondrocyte_physiolo | 2.37489327 |
| 15 | MP0002735_abnormal_chemical_nociception | 2.32821168 |
| 16 | MP0002102_abnormal_ear_morphology | 2.29624634 |
| 17 | MP0005423_abnormal_somatic_nervous | 2.29415091 |
| 18 | MP0001486_abnormal_startle_reflex | 2.28472356 |
| 19 | MP0002736_abnormal_nociception_after | 2.22071497 |
| 20 | MP0002909_abnormal_adrenal_gland | 2.18997241 |
| 21 | MP0002733_abnormal_thermal_nociception | 2.10645443 |
| 22 | MP0002822_catalepsy | 2.05288122 |
| 23 | MP0004858_abnormal_nervous_system | 1.98992565 |
| 24 | MP0001501_abnormal_sleep_pattern | 1.97535614 |
| 25 | MP0001440_abnormal_grooming_behavior | 1.95643589 |
| 26 | MP0001970_abnormal_pain_threshold | 1.92028913 |
| 27 | MP0002067_abnormal_sensory_capabilities | 1.88145083 |
| 28 | MP0000013_abnormal_adipose_tissue | 1.80889954 |
| 29 | MP0000778_abnormal_nervous_system | 1.76448745 |
| 30 | MP0004885_abnormal_endolymph | 1.74770015 |
| 31 | MP0006276_abnormal_autonomic_nervous | 1.74757463 |
| 32 | MP0002184_abnormal_innervation | 1.67205547 |
| 33 | MP0008569_lethality_at_weaning | 1.64695135 |
| 34 | MP0002557_abnormal_social/conspecific_i | 1.63233699 |
| 35 | MP0004924_abnormal_behavior | 1.62218203 |
| 36 | MP0005386_behavior/neurological_phenoty | 1.62218203 |
| 37 | MP0005646_abnormal_pituitary_gland | 1.57839628 |
| 38 | MP0000955_abnormal_spinal_cord | 1.57245432 |
| 39 | MP0004811_abnormal_neuron_physiology | 1.54510020 |
| 40 | MP0003121_genomic_imprinting | 1.49359339 |
| 41 | MP0001984_abnormal_olfaction | 1.47892694 |
| 42 | MP0003633_abnormal_nervous_system | 1.47115107 |
| 43 | MP0004043_abnormal_pH_regulation | 1.44911845 |
| 44 | MP0005645_abnormal_hypothalamus_physiol | 1.44518621 |
| 45 | MP0001529_abnormal_vocalization | 1.39949339 |
| 46 | MP0000920_abnormal_myelination | 1.36626991 |
| 47 | MP0001502_abnormal_circadian_rhythm | 1.35702552 |
| 48 | MP0002066_abnormal_motor_capabilities/c | 1.34351460 |
| 49 | MP0002882_abnormal_neuron_morphology | 1.32998109 |
| 50 | MP0000604_amyloidosis | 1.30734851 |
| 51 | MP0003879_abnormal_hair_cell | 1.27635254 |
| 52 | MP0010386_abnormal_urinary_bladder | 1.25430577 |
| 53 | MP0003690_abnormal_glial_cell | 1.25019033 |
| 54 | MP0002837_dystrophic_cardiac_calcinosis | 1.23149573 |
| 55 | MP0003631_nervous_system_phenotype | 1.22347930 |
| 56 | MP0003634_abnormal_glial_cell | 1.18308481 |
| 57 | MP0005394_taste/olfaction_phenotype | 1.15141395 |
| 58 | MP0005499_abnormal_olfactory_system | 1.15141395 |
| 59 | MP0001905_abnormal_dopamine_level | 1.13043875 |
| 60 | MP0002229_neurodegeneration | 1.10562077 |
| 61 | MP0003183_abnormal_peptide_metabolism | 1.10431644 |
| 62 | MP0004142_abnormal_muscle_tone | 1.10349628 |
| 63 | MP0003283_abnormal_digestive_organ | 1.07422895 |
| 64 | MP0003122_maternal_imprinting | 1.04272221 |
| 65 | MP0001299_abnormal_eye_distance/ | 1.03505324 |
| 66 | MP0002139_abnormal_hepatobiliary_system | 1.02019310 |
| 67 | MP0005535_abnormal_body_temperature | 1.01138187 |
| 68 | MP0002090_abnormal_vision | 0.97448327 |
| 69 | MP0003632_abnormal_nervous_system | 0.96324071 |
| 70 | MP0002152_abnormal_brain_morphology | 0.95292593 |
| 71 | MP0002069_abnormal_eating/drinking_beha | 0.94847084 |
| 72 | MP0004145_abnormal_muscle_electrophysio | 0.93636193 |
| 73 | MP0005551_abnormal_eye_electrophysiolog | 0.91732192 |
| 74 | MP0010329_abnormal_lipoprotein_level | 0.91630531 |
| 75 | MP0004742_abnormal_vestibular_system | 0.91619857 |
| 76 | MP0002234_abnormal_pharynx_morphology | 0.89839652 |
| 77 | MP0005365_abnormal_bile_salt | 0.89784772 |
| 78 | MP0003172_abnormal_lysosome_physiology | 0.86599356 |
| 79 | MP0002295_abnormal_pulmonary_circulatio | 0.85111641 |
| 80 | MP0000639_abnormal_adrenal_gland | 0.84812954 |
| 81 | MP0008789_abnormal_olfactory_epithelium | 0.84329375 |
| 82 | MP0001177_atelectasis | 0.84234179 |
| 83 | MP0000751_myopathy | 0.84145423 |
| 84 | MP0003221_abnormal_cardiomyocyte_apopto | 0.81851507 |
| 85 | MP0003075_altered_response_to | 0.81815203 |
| 86 | MP0001765_abnormal_ion_homeostasis | 0.81337026 |
| 87 | MP0008877_abnormal_DNA_methylation | 0.79818975 |
| 88 | MP0001664_abnormal_digestion | 0.79621182 |
| 89 | MP0004084_abnormal_cardiac_muscle | 0.78518131 |
| 90 | MP0003195_calcinosis | 0.78276094 |
| 91 | MP0008875_abnormal_xenobiotic_pharmacok | 0.78249413 |
| 92 | MP0010368_abnormal_lymphatic_system | 0.78233111 |
| 93 | MP0005253_abnormal_eye_physiology | 0.78162844 |
| 94 | MP0008961_abnormal_basal_metabolism | 0.77914645 |
| 95 | MP0002876_abnormal_thyroid_physiology | 0.77873178 |
| 96 | MP0001963_abnormal_hearing_physiology | 0.76895439 |
| 97 | MP0004085_abnormal_heartbeat | 0.76746395 |
| 98 | MP0004147_increased_porphyrin_level | 0.76015836 |
| 99 | MP0008775_abnormal_heart_ventricle | 0.75279539 |
| 100 | MP0002751_abnormal_autonomic_nervous | 0.74956289 |
| 101 | MP0005623_abnormal_meninges_morphology | 0.74608438 |
| 102 | MP0008874_decreased_physiological_sensi | 0.73835450 |
| 103 | MP0001986_abnormal_taste_sensitivity | 0.73550234 |
| 104 | MP0000631_abnormal_neuroendocrine_gland | 0.71596922 |
| 105 | MP0005332_abnormal_amino_acid | 0.70678374 |
| 106 | MP0002332_abnormal_exercise_endurance | 0.70328554 |
| 107 | MP0001485_abnormal_pinna_reflex | 0.69901039 |
| 108 | MP0003011_delayed_dark_adaptation | 0.68549317 |
| 109 | MP0001756_abnormal_urination | 0.68002373 |
| 110 | MP0002752_abnormal_somatic_nervous | 0.67945933 |
| 111 | MP0010234_abnormal_vibrissa_follicle | 0.66948267 |
| 112 | MP0000003_abnormal_adipose_tissue | 0.66830636 |
| 113 | MP0004233_abnormal_muscle_weight | 0.64962624 |
| 114 | MP0005187_abnormal_penis_morphology | 0.64720579 |
| 115 | MP0002638_abnormal_pupillary_reflex | 0.64114212 |
| 116 | MP0008872_abnormal_physiological_respon | 0.63336802 |
| 117 | MP0005379_endocrine/exocrine_gland_phen | 0.63033443 |
| 118 | MP0004130_abnormal_muscle_cell | 0.62644163 |
| 119 | MP0006072_abnormal_retinal_apoptosis | 0.62269597 |
| 120 | MP0001188_hyperpigmentation | 0.61633386 |
| 121 | MP0003787_abnormal_imprinting | 0.61167006 |
| 122 | MP0000747_muscle_weakness | 0.60994596 |
| 123 | MP0004215_abnormal_myocardial_fiber | 0.60309743 |
| 124 | MP0002078_abnormal_glucose_homeostasis | 0.57032407 |
| 125 | MP0003137_abnormal_impulse_conducting | 0.56499212 |
| 126 | MP0000230_abnormal_systemic_arterial | 0.56208022 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Focal motor seizures (HP:0011153) | 5.70613560 |
| 2 | Myokymia (HP:0002411) | 5.35053066 |
| 3 | Visual hallucinations (HP:0002367) | 4.52521823 |
| 4 | Focal seizures (HP:0007359) | 4.45201999 |
| 5 | Neurofibrillary tangles (HP:0002185) | 4.01688183 |
| 6 | Supranuclear gaze palsy (HP:0000605) | 3.98651599 |
| 7 | Epileptic encephalopathy (HP:0200134) | 3.89067140 |
| 8 | Action tremor (HP:0002345) | 3.82687732 |
| 9 | Cerebral inclusion bodies (HP:0100314) | 3.71156169 |
| 10 | Atonic seizures (HP:0010819) | 3.60857506 |
| 11 | Absence seizures (HP:0002121) | 3.45896065 |
| 12 | Generalized tonic-clonic seizures (HP:0002069) | 3.33402429 |
| 13 | Gait imbalance (HP:0002141) | 3.32601731 |
| 14 | Ankle clonus (HP:0011448) | 3.27814743 |
| 15 | Progressive cerebellar ataxia (HP:0002073) | 3.23520920 |
| 16 | Pheochromocytoma (HP:0002666) | 3.17425609 |
| 17 | Dialeptic seizures (HP:0011146) | 3.08865137 |
| 18 | Febrile seizures (HP:0002373) | 3.06747410 |
| 19 | Medial flaring of the eyebrow (HP:0010747) | 3.02291780 |
| 20 | Depression (HP:0000716) | 3.01210624 |
| 21 | Anxiety (HP:0000739) | 2.98377652 |
| 22 | Termporal pattern (HP:0011008) | 2.97543116 |
| 23 | Insidious onset (HP:0003587) | 2.97543116 |
| 24 | Congenital primary aphakia (HP:0007707) | 2.93284638 |
| 25 | Papilledema (HP:0001085) | 2.90890017 |
| 26 | Hyperventilation (HP:0002883) | 2.89885663 |
| 27 | Truncal ataxia (HP:0002078) | 2.83890776 |
| 28 | Abnormal eating behavior (HP:0100738) | 2.81297001 |
| 29 | Megalencephaly (HP:0001355) | 2.81085808 |
| 30 | Nephrogenic diabetes insipidus (HP:0009806) | 2.80814988 |
| 31 | Abnormality of the corticospinal tract (HP:0002492) | 2.78886240 |
| 32 | Dysmetria (HP:0001310) | 2.74304943 |
| 33 | Neuroendocrine neoplasm (HP:0100634) | 2.71029658 |
| 34 | Intention tremor (HP:0002080) | 2.69878187 |
| 35 | Spastic gait (HP:0002064) | 2.67342944 |
| 36 | Scanning speech (HP:0002168) | 2.66809351 |
| 37 | Poor eye contact (HP:0000817) | 2.66553073 |
| 38 | Elevated circulating parathyroid hormone (PTH) level (HP:0003165) | 2.65558652 |
| 39 | Mutism (HP:0002300) | 2.65463958 |
| 40 | Dysdiadochokinesis (HP:0002075) | 2.64823338 |
| 41 | Epileptiform EEG discharges (HP:0011182) | 2.63956242 |
| 42 | Impaired vibration sensation in the lower limbs (HP:0002166) | 2.63072579 |
| 43 | EEG with generalized epileptiform discharges (HP:0011198) | 2.62103854 |
| 44 | Torticollis (HP:0000473) | 2.60380168 |
| 45 | Broad-based gait (HP:0002136) | 2.58822402 |
| 46 | Postural instability (HP:0002172) | 2.56955125 |
| 47 | Spastic tetraplegia (HP:0002510) | 2.55963635 |
| 48 | Urinary urgency (HP:0000012) | 2.55377914 |
| 49 | Hypothermia (HP:0002045) | 2.54467602 |
| 50 | Hypsarrhythmia (HP:0002521) | 2.52207115 |
| 51 | Methylmalonic acidemia (HP:0002912) | 2.51137238 |
| 52 | Agitation (HP:0000713) | 2.50986492 |
| 53 | Impaired social interactions (HP:0000735) | 2.49508940 |
| 54 | Abnormal social behavior (HP:0012433) | 2.49508940 |
| 55 | Drooling (HP:0002307) | 2.46471696 |
| 56 | Excessive salivation (HP:0003781) | 2.46471696 |
| 57 | Poor suck (HP:0002033) | 2.45142637 |
| 58 | Limb dystonia (HP:0002451) | 2.42331892 |
| 59 | Hemiparesis (HP:0001269) | 2.41701774 |
| 60 | Urinary bladder sphincter dysfunction (HP:0002839) | 2.40528586 |
| 61 | Epidermoid cyst (HP:0200040) | 2.38582137 |
| 62 | Increased circulating renin level (HP:0000848) | 2.38485757 |
| 63 | Focal dystonia (HP:0004373) | 2.35649539 |
| 64 | Renal cortical cysts (HP:0000803) | 2.35523335 |
| 65 | Progressive inability to walk (HP:0002505) | 2.32772026 |
| 66 | Genital tract atresia (HP:0001827) | 2.28186875 |
| 67 | Degeneration of the lateral corticospinal tracts (HP:0002314) | 2.27074241 |
| 68 | Atrophy/Degeneration involving the corticospinal tracts (HP:0007372) | 2.27074241 |
| 69 | Craniofacial dystonia (HP:0012179) | 2.23349755 |
| 70 | Lower limb muscle weakness (HP:0007340) | 2.23200923 |
| 71 | Vaginal atresia (HP:0000148) | 2.22801880 |
| 72 | Gaze-evoked nystagmus (HP:0000640) | 2.22611409 |
| 73 | Amblyopia (HP:0000646) | 2.22596674 |
| 74 | Abnormality of the hip-girdle musculature (HP:0001445) | 2.22244654 |
| 75 | Abnormality of the musculature of the pelvis (HP:0001469) | 2.22244654 |
| 76 | Delayed gross motor development (HP:0002194) | 2.22041831 |
| 77 | Polyphagia (HP:0002591) | 2.17044859 |
| 78 | Blue irides (HP:0000635) | 2.17018945 |
| 79 | Diplopia (HP:0000651) | 2.15644307 |
| 80 | Abnormality of binocular vision (HP:0011514) | 2.15644307 |
| 81 | Bradykinesia (HP:0002067) | 2.14217060 |
| 82 | Specific learning disability (HP:0001328) | 2.07781114 |
| 83 | Akinesia (HP:0002304) | 2.07643207 |
| 84 | Neuronal loss in central nervous system (HP:0002529) | 2.06372347 |
| 85 | Status epilepticus (HP:0002133) | 2.05372392 |
| 86 | Retinal dysplasia (HP:0007973) | 2.03217283 |
| 87 | Generalized myoclonic seizures (HP:0002123) | 2.02021651 |
| 88 | Hypoglycemic coma (HP:0001325) | 1.99290449 |
| 89 | Abnormality of aromatic amino acid family metabolism (HP:0004338) | 1.99214782 |
| 90 | Type II lissencephaly (HP:0007260) | 1.96394101 |
| 91 | Psychosis (HP:0000709) | 1.95416867 |
| 92 | Clonus (HP:0002169) | 1.93711207 |
| 93 | Split foot (HP:0001839) | 1.92414252 |
| 94 | Retinal atrophy (HP:0001105) | 1.91665172 |
| 95 | Ketoacidosis (HP:0001993) | 1.90687924 |
| 96 | Postural tremor (HP:0002174) | 1.90268280 |
| 97 | Proximal tubulopathy (HP:0000114) | 1.90208896 |
| 98 | Rigidity (HP:0002063) | 1.89966197 |
| 99 | Paraplegia (HP:0010550) | 1.89476083 |
| 100 | Muscular hypotonia of the trunk (HP:0008936) | 1.89141418 |
| 101 | Hyperglycinemia (HP:0002154) | 1.88775550 |
| 102 | Lissencephaly (HP:0001339) | 1.88655973 |
| 103 | Shoulder girdle muscle weakness (HP:0003547) | 1.87825671 |
| 104 | Esotropia (HP:0000565) | 1.87538092 |
| 105 | Absent speech (HP:0001344) | 1.86735527 |
| 106 | Hemiplegia (HP:0002301) | 1.85847173 |
| 107 | Stereotypic behavior (HP:0000733) | 1.85265974 |
| 108 | Poor coordination (HP:0002370) | 1.84143825 |
| 109 | Gait ataxia (HP:0002066) | 1.83905065 |
| 110 | Abnormality of calcium-phosphate metabolism (HP:0100530) | 1.83022118 |
| 111 | Papillary thyroid carcinoma (HP:0002895) | 1.82703195 |
| 112 | Decreased number of large peripheral myelinated nerve fibers (HP:0003387) | 1.81313772 |
| 113 | Rapidly progressive (HP:0003678) | 1.81254855 |
| 114 | Abnormality of the lower motor neuron (HP:0002366) | 1.78868344 |
| 115 | Hepatoblastoma (HP:0002884) | 1.78523229 |
| 116 | Decreased testicular size (HP:0008734) | 1.78382498 |
| 117 | Pachygyria (HP:0001302) | 1.76605077 |
| 118 | Impaired smooth pursuit (HP:0007772) | 1.76514808 |
| 119 | Fetal akinesia sequence (HP:0001989) | 1.76085571 |
| 120 | Neoplasm of the peripheral nervous system (HP:0100007) | 1.76013353 |
| 121 | Ventricular fibrillation (HP:0001663) | 1.74698334 |
| 122 | Amyotrophic lateral sclerosis (HP:0007354) | 1.74119682 |
| 123 | Thyroid-stimulating hormone excess (HP:0002925) | 1.74113602 |
| 124 | Upper limb muscle weakness (HP:0003484) | 1.73887588 |
| 125 | Morphological abnormality of the pyramidal tract (HP:0002062) | 1.73686453 |
| 126 | Aplasia involving bones of the extremities (HP:0009825) | 1.73087217 |
| 127 | Aplasia involving bones of the upper limbs (HP:0009823) | 1.73087217 |
| 128 | Aplasia of the phalanges of the hand (HP:0009802) | 1.73087217 |
| 129 | Sensorimotor neuropathy (HP:0007141) | 1.72520237 |
| 130 | Genetic anticipation (HP:0003743) | 1.72346395 |
| 131 | Metabolic alkalosis (HP:0200114) | 1.72006823 |
| 132 | Peripheral hypomyelination (HP:0007182) | 1.71577977 |
| 133 | Aplasia/Hypoplasia of the lens (HP:0008063) | 1.70658452 |
| 134 | Hammertoe (HP:0001765) | 1.70550215 |
| 135 | Decreased muscle mass (HP:0003199) | 1.70122423 |
| 136 | Resting tremor (HP:0002322) | 1.69930911 |
| 137 | Ketosis (HP:0001946) | 1.69167126 |
| 138 | Inability to walk (HP:0002540) | 1.69161349 |
| 139 | Impaired vibratory sensation (HP:0002495) | 1.69020529 |
| 140 | Abnormality of vitamin metabolism (HP:0100508) | 1.67631608 |
| 141 | Abnormality of vitamin B metabolism (HP:0004340) | 1.67515577 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | NTRK3 | 3.95885342 |
| 2 | EPHA4 | 3.61587586 |
| 3 | MAP3K9 | 3.39194671 |
| 4 | MARK1 | 3.20708918 |
| 5 | MAP3K4 | 2.56612957 |
| 6 | MINK1 | 2.54421241 |
| 7 | NTRK1 | 2.39754477 |
| 8 | TRIM28 | 2.36797919 |
| 9 | MAP4K2 | 2.28622416 |
| 10 | KSR2 | 2.25252163 |
| 11 | MAP2K7 | 2.01529098 |
| 12 | MAP3K12 | 2.01145653 |
| 13 | DAPK2 | 1.95816335 |
| 14 | PAK6 | 1.92002401 |
| 15 | PRKD3 | 1.88749996 |
| 16 | MAP2K4 | 1.86740172 |
| 17 | NTRK2 | 1.83677293 |
| 18 | EPHA3 | 1.73695354 |
| 19 | MAP3K2 | 1.66923585 |
| 20 | OXSR1 | 1.59797723 |
| 21 | WNK4 | 1.58499585 |
| 22 | CAMKK1 | 1.56007330 |
| 23 | CASK | 1.54353562 |
| 24 | KSR1 | 1.53492412 |
| 25 | CDK5 | 1.50573350 |
| 26 | CSNK1G1 | 1.44198202 |
| 27 | STK39 | 1.43395790 |
| 28 | RIPK4 | 1.42159965 |
| 29 | CAMKK2 | 1.40072244 |
| 30 | WNK3 | 1.39628248 |
| 31 | UHMK1 | 1.35669913 |
| 32 | ARAF | 1.33354690 |
| 33 | PHKG2 | 1.31720612 |
| 34 | PHKG1 | 1.31720612 |
| 35 | PLK2 | 1.22847569 |
| 36 | GRK5 | 1.21751999 |
| 37 | TNIK | 1.16532584 |
| 38 | TESK1 | 1.15587008 |
| 39 | PAK3 | 1.13996289 |
| 40 | CDK19 | 1.12363630 |
| 41 | SGK494 | 1.12356952 |
| 42 | SGK223 | 1.12356952 |
| 43 | RET | 1.09855751 |
| 44 | MAPK13 | 1.09559278 |
| 45 | PRKCG | 1.05760968 |
| 46 | FRK | 1.04223554 |
| 47 | WNK1 | 1.03479298 |
| 48 | MYLK | 1.02760983 |
| 49 | MAP3K13 | 0.99903179 |
| 50 | LMTK2 | 0.99428437 |
| 51 | CAMK2A | 0.98157874 |
| 52 | DYRK2 | 0.98029778 |
| 53 | STK38L | 0.92877674 |
| 54 | CAMK2B | 0.92575770 |
| 55 | CSNK1G2 | 0.91713502 |
| 56 | DAPK1 | 0.91370797 |
| 57 | FGFR2 | 0.90913275 |
| 58 | BCKDK | 0.90695040 |
| 59 | GRK1 | 0.90557486 |
| 60 | PNCK | 0.90247729 |
| 61 | RPS6KA4 | 0.88307380 |
| 62 | TYRO3 | 0.87690022 |
| 63 | CDK14 | 0.87425999 |
| 64 | BCR | 0.87074267 |
| 65 | SCYL2 | 0.86125998 |
| 66 | INSRR | 0.85795127 |
| 67 | STK38 | 0.84564314 |
| 68 | PRKCH | 0.82964407 |
| 69 | FER | 0.82459517 |
| 70 | MAP3K1 | 0.82077341 |
| 71 | CDK18 | 0.80629854 |
| 72 | DYRK3 | 0.80322367 |
| 73 | CDK15 | 0.78223428 |
| 74 | PRPF4B | 0.76619318 |
| 75 | PTK2B | 0.75368471 |
| 76 | PINK1 | 0.75235607 |
| 77 | SIK2 | 0.73683825 |
| 78 | PIK3CA | 0.72805933 |
| 79 | PRKCE | 0.72410668 |
| 80 | MAP3K5 | 0.70469972 |
| 81 | CAMK2D | 0.67749308 |
| 82 | LATS2 | 0.67132064 |
| 83 | CCNB1 | 0.65850453 |
| 84 | SIK3 | 0.64944805 |
| 85 | CDK11A | 0.64904376 |
| 86 | FES | 0.64641210 |
| 87 | SGK1 | 0.63903540 |
| 88 | PDPK1 | 0.63623885 |
| 89 | STK11 | 0.63087910 |
| 90 | CAMK1G | 0.63008323 |
| 91 | OBSCN | 0.62988952 |
| 92 | DYRK1A | 0.61816437 |
| 93 | FLT3 | 0.61346512 |
| 94 | ADRBK2 | 0.59697087 |
| 95 | PDK1 | 0.59313733 |
| 96 | LIMK1 | 0.58919392 |
| 97 | CAMK2G | 0.58296001 |
| 98 | MAP2K1 | 0.57679954 |
| 99 | RIPK1 | 0.57386478 |
| 100 | RAF1 | 0.56773305 |
| 101 | DYRK1B | 0.56225504 |
| 102 | PRKCZ | 0.56045489 |
| 103 | SGK2 | 0.54940651 |
| 104 | CAMK1 | 0.52221247 |
| 105 | MARK2 | 0.52219587 |
| 106 | MAP3K6 | 0.51247235 |
| 107 | SGK3 | 0.51004955 |
| 108 | TIE1 | 0.49748487 |
| 109 | MAPKAPK5 | 0.48530518 |
| 110 | FYN | 0.47856509 |
| 111 | PRKAA1 | 0.47233157 |
| 112 | BMPR2 | 0.47143859 |
| 113 | CAMK4 | 0.46979173 |
| 114 | CSNK1A1L | 0.46509492 |
| 115 | PRKACA | 0.45733645 |
| 116 | ROCK2 | 0.44765305 |
| 117 | CSNK1G3 | 0.44051334 |
| 118 | CSNK1A1 | 0.43505583 |
| 119 | PDK3 | 0.43408958 |
| 120 | PDK4 | 0.43408958 |
| 121 | PKN1 | 0.43143218 |
| 122 | CDC42BPA | 0.42254234 |
| 123 | ERBB3 | 0.42142770 |
| 124 | FGR | 0.41720544 |
| 125 | MAPKAPK3 | 0.41660493 |
| 126 | RPS6KA3 | 0.41238831 |
| 127 | NEK6 | 0.40376246 |
| 128 | PRKG1 | 0.40360767 |
| 129 | EPHB2 | 0.38240805 |
| 130 | CSNK1D | 0.38190708 |
| 131 | PRKACG | 0.37876895 |
| 132 | BMPR1B | 0.36816378 |
| 133 | PRKACB | 0.34999299 |
| 134 | LATS1 | 0.34496667 |
| 135 | AKT3 | 0.34368771 |
| 136 | PKN2 | 0.33935895 |
| 137 | DDR2 | 0.33556299 |
| 138 | ROCK1 | 0.32095887 |
| 139 | EGFR | 0.30073451 |
| 140 | PRKCA | 0.28762490 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Nicotine addiction_Homo sapiens_hsa05033 | 2.98673637 |
| 2 | Synaptic vesicle cycle_Homo sapiens_hsa04721 | 2.83519445 |
| 3 | GABAergic synapse_Homo sapiens_hsa04727 | 2.44987633 |
| 4 | Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 | 2.28963714 |
| 5 | Circadian entrainment_Homo sapiens_hsa04713 | 2.26847168 |
| 6 | Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 | 2.25994685 |
| 7 | Long-term potentiation_Homo sapiens_hsa04720 | 2.19383917 |
| 8 | Morphine addiction_Homo sapiens_hsa05032 | 2.12684374 |
| 9 | Glutamatergic synapse_Homo sapiens_hsa04724 | 2.12482412 |
| 10 | Amphetamine addiction_Homo sapiens_hsa05031 | 2.09321032 |
| 11 | Insulin secretion_Homo sapiens_hsa04911 | 2.08002306 |
| 12 | Olfactory transduction_Homo sapiens_hsa04740 | 2.07453955 |
| 13 | Dopaminergic synapse_Homo sapiens_hsa04728 | 1.93348100 |
| 14 | Salivary secretion_Homo sapiens_hsa04970 | 1.86309826 |
| 15 | Protein export_Homo sapiens_hsa03060 | 1.73402786 |
| 16 | Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962 | 1.69658704 |
| 17 | Gastric acid secretion_Homo sapiens_hsa04971 | 1.69073372 |
| 18 | Nitrogen metabolism_Homo sapiens_hsa00910 | 1.68613730 |
| 19 | Cholinergic synapse_Homo sapiens_hsa04725 | 1.61736927 |
| 20 | Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 | 1.61607491 |
| 21 | Cocaine addiction_Homo sapiens_hsa05030 | 1.61550772 |
| 22 | Renin secretion_Homo sapiens_hsa04924 | 1.60220473 |
| 23 | Taste transduction_Homo sapiens_hsa04742 | 1.53468054 |
| 24 | Aldosterone synthesis and secretion_Homo sapiens_hsa04925 | 1.52720079 |
| 25 | Collecting duct acid secretion_Homo sapiens_hsa04966 | 1.50679144 |
| 26 | Serotonergic synapse_Homo sapiens_hsa04726 | 1.48213106 |
| 27 | Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563 | 1.47522957 |
| 28 | Long-term depression_Homo sapiens_hsa04730 | 1.45209349 |
| 29 | Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 | 1.42507268 |
| 30 | Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 | 1.34010563 |
| 31 | Oxytocin signaling pathway_Homo sapiens_hsa04921 | 1.28301180 |
| 32 | Vibrio cholerae infection_Homo sapiens_hsa05110 | 1.27051704 |
| 33 | Steroid biosynthesis_Homo sapiens_hsa00100 | 1.24415775 |
| 34 | Propanoate metabolism_Homo sapiens_hsa00640 | 1.20816387 |
| 35 | Gap junction_Homo sapiens_hsa04540 | 1.20294630 |
| 36 | Calcium signaling pathway_Homo sapiens_hsa04020 | 1.19438803 |
| 37 | beta-Alanine metabolism_Homo sapiens_hsa00410 | 1.14331354 |
| 38 | GnRH signaling pathway_Homo sapiens_hsa04912 | 1.13718769 |
| 39 | Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 | 1.13148023 |
| 40 | Type II diabetes mellitus_Homo sapiens_hsa04930 | 1.13124572 |
| 41 | Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534 | 1.12608457 |
| 42 | Regulation of autophagy_Homo sapiens_hsa04140 | 1.12169992 |
| 43 | Ascorbate and aldarate metabolism_Homo sapiens_hsa00053 | 1.10793619 |
| 44 | cAMP signaling pathway_Homo sapiens_hsa04024 | 1.06903808 |
| 45 | Axon guidance_Homo sapiens_hsa04360 | 1.05228247 |
| 46 | Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 | 1.03816653 |
| 47 | Pathogenic Escherichia coli infection_Homo sapiens_hsa05130 | 1.03485421 |
| 48 | Estrogen signaling pathway_Homo sapiens_hsa04915 | 1.02998844 |
| 49 | Fatty acid elongation_Homo sapiens_hsa00062 | 1.01171679 |
| 50 | Primary bile acid biosynthesis_Homo sapiens_hsa00120 | 0.99695603 |
| 51 | Pancreatic secretion_Homo sapiens_hsa04972 | 0.98140798 |
| 52 | Butanoate metabolism_Homo sapiens_hsa00650 | 0.95843832 |
| 53 | Peroxisome_Homo sapiens_hsa04146 | 0.94523855 |
| 54 | Thyroid hormone synthesis_Homo sapiens_hsa04918 | 0.94150446 |
| 55 | Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072 | 0.94106439 |
| 56 | Phosphatidylinositol signaling system_Homo sapiens_hsa04070 | 0.89891854 |
| 57 | Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604 | 0.88931509 |
| 58 | Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130 | 0.88726061 |
| 59 | cGMP-PKG signaling pathway_Homo sapiens_hsa04022 | 0.87665975 |
| 60 | Carbohydrate digestion and absorption_Homo sapiens_hsa04973 | 0.87427805 |
| 61 | Bile secretion_Homo sapiens_hsa04976 | 0.85934187 |
| 62 | Glioma_Homo sapiens_hsa05214 | 0.85402972 |
| 63 | Melanogenesis_Homo sapiens_hsa04916 | 0.85396144 |
| 64 | Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 | 0.85189681 |
| 65 | Steroid hormone biosynthesis_Homo sapiens_hsa00140 | 0.84077641 |
| 66 | Dorso-ventral axis formation_Homo sapiens_hsa04320 | 0.82329854 |
| 67 | Vascular smooth muscle contraction_Homo sapiens_hsa04270 | 0.81959010 |
| 68 | Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 | 0.81481513 |
| 69 | Taurine and hypotaurine metabolism_Homo sapiens_hsa00430 | 0.81168484 |
| 70 | Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 | 0.80528866 |
| 71 | Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410 | 0.79564393 |
| 72 | Sulfur metabolism_Homo sapiens_hsa00920 | 0.78714215 |
| 73 | ErbB signaling pathway_Homo sapiens_hsa04012 | 0.76735000 |
| 74 | Vitamin B6 metabolism_Homo sapiens_hsa00750 | 0.76402364 |
| 75 | Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 | 0.73117722 |
| 76 | Fatty acid degradation_Homo sapiens_hsa00071 | 0.72441709 |
| 77 | Glycosaminoglycan degradation_Homo sapiens_hsa00531 | 0.72187020 |
| 78 | Starch and sucrose metabolism_Homo sapiens_hsa00500 | 0.72104166 |
| 79 | Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 | 0.71009390 |
| 80 | Cardiac muscle contraction_Homo sapiens_hsa04260 | 0.70129037 |
| 81 | Pentose and glucuronate interconversions_Homo sapiens_hsa00040 | 0.68438308 |
| 82 | Phospholipase D signaling pathway_Homo sapiens_hsa04072 | 0.65597080 |
| 83 | Arginine and proline metabolism_Homo sapiens_hsa00330 | 0.63941554 |
| 84 | Maturity onset diabetes of the young_Homo sapiens_hsa04950 | 0.63669712 |
| 85 | Glucagon signaling pathway_Homo sapiens_hsa04922 | 0.63492520 |
| 86 | Oxidative phosphorylation_Homo sapiens_hsa00190 | 0.63082818 |
| 87 | Complement and coagulation cascades_Homo sapiens_hsa04610 | 0.62784767 |
| 88 | Prion diseases_Homo sapiens_hsa05020 | 0.61836592 |
| 89 | Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250 | 0.61559836 |
| 90 | Chemical carcinogenesis_Homo sapiens_hsa05204 | 0.60126885 |
| 91 | Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040 | 0.59442396 |
| 92 | PPAR signaling pathway_Homo sapiens_hsa03320 | 0.58031755 |
| 93 | Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 | 0.56905495 |
| 94 | Choline metabolism in cancer_Homo sapiens_hsa05231 | 0.55911735 |
| 95 | Tryptophan metabolism_Homo sapiens_hsa00380 | 0.53804725 |
| 96 | Dilated cardiomyopathy_Homo sapiens_hsa05414 | 0.53682837 |
| 97 | Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630 | 0.52431837 |
| 98 | Retinol metabolism_Homo sapiens_hsa00830 | 0.51789987 |
| 99 | Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603 | 0.49949475 |
| 100 | Sphingolipid signaling pathway_Homo sapiens_hsa04071 | 0.48665556 |
| 101 | Ether lipid metabolism_Homo sapiens_hsa00565 | 0.48425316 |
| 102 | Renin-angiotensin system_Homo sapiens_hsa04614 | 0.48163799 |
| 103 | Pyruvate metabolism_Homo sapiens_hsa00620 | 0.47851082 |
| 104 | Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 | 0.47485832 |
| 105 | Histidine metabolism_Homo sapiens_hsa00340 | 0.46527493 |
| 106 | Oocyte meiosis_Homo sapiens_hsa04114 | 0.46415664 |
| 107 | Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512 | 0.45976820 |
| 108 | Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 | 0.45519911 |
| 109 | 2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210 | 0.45316294 |
| 110 | Fatty acid biosynthesis_Homo sapiens_hsa00061 | 0.44729664 |
| 111 | Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514 | 0.44301502 |
| 112 | Circadian rhythm_Homo sapiens_hsa04710 | 0.43781149 |
| 113 | SNARE interactions in vesicular transport_Homo sapiens_hsa04130 | 0.43360400 |
| 114 | Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 | 0.43325127 |
| 115 | Phagosome_Homo sapiens_hsa04145 | 0.43252258 |
| 116 | Ras signaling pathway_Homo sapiens_hsa04014 | 0.43160565 |
| 117 | Neurotrophin signaling pathway_Homo sapiens_hsa04722 | 0.42957541 |
| 118 | Renal cell carcinoma_Homo sapiens_hsa05211 | 0.42939261 |
| 119 | Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524 | 0.42931268 |
| 120 | Folate biosynthesis_Homo sapiens_hsa00790 | 0.42900092 |
| 121 | MAPK signaling pathway_Homo sapiens_hsa04010 | 0.42791651 |
| 122 | Endocytosis_Homo sapiens_hsa04144 | 0.42718847 |
| 123 | VEGF signaling pathway_Homo sapiens_hsa04370 | 0.42123664 |
| 124 | Phototransduction_Homo sapiens_hsa04744 | 0.41697161 |
| 125 | Alzheimers disease_Homo sapiens_hsa05010 | 0.40775437 |
| 126 | Inositol phosphate metabolism_Homo sapiens_hsa00562 | 0.39958142 |
| 127 | Ovarian steroidogenesis_Homo sapiens_hsa04913 | 0.39780269 |
| 128 | Citrate cycle (TCA cycle)_Homo sapiens_hsa00020 | 0.38473558 |
| 129 | Lysosome_Homo sapiens_hsa04142 | 0.37730103 |
| 130 | Rap1 signaling pathway_Homo sapiens_hsa04015 | 0.37360339 |
| 131 | Insulin signaling pathway_Homo sapiens_hsa04910 | 0.37223407 |
| 132 | Type I diabetes mellitus_Homo sapiens_hsa04940 | 0.37060513 |
| 133 | Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 | 0.36743211 |
| 134 | Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400 | 0.34885464 |
| 135 | Arginine biosynthesis_Homo sapiens_hsa00220 | 0.34194781 |
| 136 | Alcoholism_Homo sapiens_hsa05034 | 0.33549592 |
| 137 | Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412 | 0.32788046 |
| 138 | Mineral absorption_Homo sapiens_hsa04978 | 0.32391813 |
| 139 | Fatty acid metabolism_Homo sapiens_hsa01212 | 0.31141447 |
| 140 | Thyroid hormone signaling pathway_Homo sapiens_hsa04919 | 0.28125774 |

