ITFG2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1maturation of SSU-rRNA (GO:0030490)4.00402194
2ribosomal small subunit assembly (GO:0000028)3.92922832
3chromatin remodeling at centromere (GO:0031055)3.90597869
4mitochondrial respiratory chain complex assembly (GO:0033108)3.90162607
5CENP-A containing nucleosome assembly (GO:0034080)3.77156279
6response to pheromone (GO:0019236)3.71028207
7viral transcription (GO:0019083)3.65362987
8nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.54820118
9exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.53098480
10translational termination (GO:0006415)3.52975524
11GPI anchor biosynthetic process (GO:0006506)3.52410897
12histone exchange (GO:0043486)3.51762986
13establishment of protein localization to mitochondrial membrane (GO:0090151)3.51578118
14meiotic chromosome segregation (GO:0045132)3.51347206
15centriole assembly (GO:0098534)3.50086707
16axon ensheathment in central nervous system (GO:0032291)3.46210269
17central nervous system myelination (GO:0022010)3.46210269
18pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.45166781
19respiratory chain complex IV assembly (GO:0008535)3.42664502
20preassembly of GPI anchor in ER membrane (GO:0016254)3.35692343
21regulation of mitochondrial translation (GO:0070129)3.33748227
22pseudouridine synthesis (GO:0001522)3.19489935
23presynaptic membrane assembly (GO:0097105)3.18942701
24protein K6-linked ubiquitination (GO:0085020)3.17969024
25chaperone-mediated protein transport (GO:0072321)3.16897898
26mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.16654972
27developmental pigmentation (GO:0048066)3.15685252
28GPI anchor metabolic process (GO:0006505)3.13920812
29histone H2B ubiquitination (GO:0033523)3.11217112
30DNA strand elongation involved in DNA replication (GO:0006271)3.11036868
31mesenchymal cell differentiation involved in renal system development (GO:2001012)3.09973799
32mesenchymal cell differentiation involved in kidney development (GO:0072161)3.09973799
33amino sugar catabolic process (GO:0046348)3.08715938
34peptidyl-histidine modification (GO:0018202)3.06159850
35mannosylation (GO:0097502)3.05923977
36translational elongation (GO:0006414)3.05616173
37SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.04976039
38DNA replication checkpoint (GO:0000076)3.02374651
39telomere maintenance via semi-conservative replication (GO:0032201)3.02249288
40cotranslational protein targeting to membrane (GO:0006613)3.00178604
41pyrimidine nucleotide catabolic process (GO:0006244)2.99904220
42limb bud formation (GO:0060174)2.99864564
43presynaptic membrane organization (GO:0097090)2.99106196
44cytochrome complex assembly (GO:0017004)2.97746903
45tRNA methylation (GO:0030488)2.97536778
46superoxide anion generation (GO:0042554)2.97487350
47recombinational repair (GO:0000725)2.97399836
48centriole replication (GO:0007099)2.96800815
49glucosamine-containing compound catabolic process (GO:1901072)2.96629341
50DNA integration (GO:0015074)2.96081905
51protein targeting to ER (GO:0045047)2.95821633
52energy coupled proton transport, down electrochemical gradient (GO:0015985)2.95696765
53ATP synthesis coupled proton transport (GO:0015986)2.95696765
54DNA replication-independent nucleosome organization (GO:0034724)2.95475776
55DNA replication-independent nucleosome assembly (GO:0006336)2.95475776
56double-strand break repair via homologous recombination (GO:0000724)2.95325416
57regulation of timing of cell differentiation (GO:0048505)2.94340780
58postsynaptic membrane organization (GO:0001941)2.94294828
59DNA strand elongation (GO:0022616)2.93119960
60deoxyribonucleotide catabolic process (GO:0009264)2.92732659
61regulation of rhodopsin mediated signaling pathway (GO:0022400)2.91006275
62rRNA processing (GO:0006364)2.90009218
63DNA strand renaturation (GO:0000733)2.87822892
64rRNA metabolic process (GO:0016072)2.86158171
65DNA ligation (GO:0006266)2.84945872
66spliceosomal complex assembly (GO:0000245)2.84921851
67rhodopsin mediated signaling pathway (GO:0016056)2.84473120
68long-chain fatty acid biosynthetic process (GO:0042759)2.82953824
69ubiquinone biosynthetic process (GO:0006744)2.82704356
70lymphoid progenitor cell differentiation (GO:0002320)2.82591981
71C-terminal protein lipidation (GO:0006501)2.80390740
72protein heterotetramerization (GO:0051290)2.80238469
73facial nerve structural organization (GO:0021612)2.78956385
74proteasome assembly (GO:0043248)2.78746995
75DNA deamination (GO:0045006)2.78106444
76protein localization to endoplasmic reticulum (GO:0070972)2.77265754
77sperm motility (GO:0030317)2.77150363
78cellular component biogenesis (GO:0044085)2.75885927
79establishment of protein localization to endoplasmic reticulum (GO:0072599)2.75876136
80cranial nerve morphogenesis (GO:0021602)2.75077630
81negative regulation of myoblast differentiation (GO:0045662)2.74752752
82base-excision repair, AP site formation (GO:0006285)2.73980958
83replication fork processing (GO:0031297)2.73919916
84cellular protein complex disassembly (GO:0043624)2.73686541
85negative regulation of execution phase of apoptosis (GO:1900118)2.72955618
86translational initiation (GO:0006413)2.71905458
87DNA damage response, detection of DNA damage (GO:0042769)2.71819988
88photoreceptor cell maintenance (GO:0045494)2.70297887
89regulation of development, heterochronic (GO:0040034)2.69326545
90deoxyribose phosphate catabolic process (GO:0046386)2.68896754
91positive regulation of transcription elongation from RNA polymerase II promoter (GO:0032968)2.68164484
92energy homeostasis (GO:0097009)2.68138201
93kinetochore assembly (GO:0051382)2.67638800
94regulation of pigment cell differentiation (GO:0050932)2.67521138
95nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.66968241
96deoxyribonucleoside triphosphate metabolic process (GO:0009200)2.65938992
97water-soluble vitamin biosynthetic process (GO:0042364)2.65004018
98viral life cycle (GO:0019058)2.64965103
99ribonucleoprotein complex biogenesis (GO:0022613)2.64437211
100telomere maintenance via recombination (GO:0000722)2.63831269
101DNA recombination (GO:0006310)2.63455269
102chromosome condensation (GO:0030261)2.63132301
103keratinocyte development (GO:0003334)2.62899709
104sympathetic nervous system development (GO:0048485)2.61497311
105mismatch repair (GO:0006298)2.60169095
106microtubule depolymerization (GO:0007019)2.60115803
107mitochondrial calcium ion transport (GO:0006851)2.59276930
108righting reflex (GO:0060013)2.58025259
109translation (GO:0006412)2.57602235
110cranial nerve structural organization (GO:0021604)2.56372112
111androgen biosynthetic process (GO:0006702)2.56268685
112purine deoxyribonucleotide catabolic process (GO:0009155)2.56199157
113regulation of nuclear cell cycle DNA replication (GO:0033262)2.55599499
114nuclear-transcribed mRNA catabolic process (GO:0000956)2.55243376
115negative regulation of transcription by competitive promoter binding (GO:0010944)2.54381156
116mitotic sister chromatid segregation (GO:0000070)2.54296622
117C-terminal protein amino acid modification (GO:0018410)2.54142021
118nucleotide transmembrane transport (GO:1901679)2.54118044
119DNA double-strand break processing (GO:0000729)2.53648529
120DNA packaging (GO:0006323)2.52948167
121reciprocal meiotic recombination (GO:0007131)2.52663783
122reciprocal DNA recombination (GO:0035825)2.52663783
123female gonad development (GO:0008585)2.51437120
124ubiquinone metabolic process (GO:0006743)2.50908739
125negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.50266268
126negative regulation of DNA-dependent DNA replication (GO:2000104)2.49531670
127protein complex disassembly (GO:0043241)2.49359043
128termination of RNA polymerase II transcription (GO:0006369)2.48881485
129ncRNA processing (GO:0034470)2.48679752
130cell proliferation in forebrain (GO:0021846)2.48060291
131termination of RNA polymerase III transcription (GO:0006386)2.47423552
132transcription elongation from RNA polymerase III promoter (GO:0006385)2.47423552
133rRNA methylation (GO:0031167)2.47375680
134chromosome segregation (GO:0007059)2.46791399
135spliceosomal snRNP assembly (GO:0000387)2.46714030
136rRNA modification (GO:0000154)2.44796263
137oligosaccharide catabolic process (GO:0009313)2.43230029
138spinal cord motor neuron differentiation (GO:0021522)2.40564518
139axoneme assembly (GO:0035082)2.39343318
140nonmotile primary cilium assembly (GO:0035058)2.39276460
141transcription elongation from RNA polymerase I promoter (GO:0006362)2.36767144
142mesonephros development (GO:0001823)2.36469619
143tRNA modification (GO:0006400)2.36307208
144eye photoreceptor cell development (GO:0042462)2.36208715
145photoreceptor cell differentiation (GO:0046530)2.36169090
146eye photoreceptor cell differentiation (GO:0001754)2.36169090
147retina layer formation (GO:0010842)2.34541721
148protein complex biogenesis (GO:0070271)2.33998758
149ribosomal small subunit biogenesis (GO:0042274)2.33979925
150RNA methylation (GO:0001510)2.33953874
151termination of RNA polymerase I transcription (GO:0006363)2.32471440
152startle response (GO:0001964)2.32053791
153tRNA processing (GO:0008033)2.31555797
154positive regulation of protein homodimerization activity (GO:0090073)2.30757795
155cell differentiation in spinal cord (GO:0021515)2.28131201
156histone H3-K4 trimethylation (GO:0080182)2.25466412
157otic vesicle formation (GO:0030916)2.25157841
158GTP biosynthetic process (GO:0006183)2.24885033
159photoreceptor cell development (GO:0042461)2.23868802
160positive regulation of uterine smooth muscle contraction (GO:0070474)2.22542509
161cerebral cortex radially oriented cell migration (GO:0021799)2.22026222
162mitochondrial respiratory chain complex I assembly (GO:0032981)2.21148536
163NADH dehydrogenase complex assembly (GO:0010257)2.21148536
164mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.21148536
165DNA methylation involved in gamete generation (GO:0043046)2.20814966
166detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.20437790
167sphingoid metabolic process (GO:0046519)2.20263732
168kinetochore organization (GO:0051383)2.19244278
169glycolipid biosynthetic process (GO:0009247)2.16771563
170regulation of feeding behavior (GO:0060259)2.16530896
171detection of light stimulus involved in visual perception (GO:0050908)2.13834026
172detection of light stimulus involved in sensory perception (GO:0050962)2.13834026
173mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.11191488
174pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.10283193
175deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.10176483

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human3.82966474
2GABP_17652178_ChIP-ChIP_JURKAT_Human3.42399240
3GBX2_23144817_ChIP-Seq_PC3_Human3.41847212
4E2F7_22180533_ChIP-Seq_HELA_Human3.34667363
5FOXM1_23109430_ChIP-Seq_U2OS_Human2.99155204
6ETS1_20019798_ChIP-Seq_JURKAT_Human2.97872332
7E2F4_17652178_ChIP-ChIP_JURKAT_Human2.86630709
8EZH2_22144423_ChIP-Seq_EOC_Human2.83522534
9FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.83221731
10SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.78576004
11PCGF2_27294783_Chip-Seq_ESCs_Mouse2.76301410
12BMI1_23680149_ChIP-Seq_NPCS_Mouse2.69360780
13VDR_23849224_ChIP-Seq_CD4+_Human2.67933986
14FOXP3_21729870_ChIP-Seq_TREG_Human2.63948123
15ZFP57_27257070_Chip-Seq_ESCs_Mouse2.61337897
16* MYC_18555785_ChIP-Seq_MESCs_Mouse2.52120706
17E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.47959186
18FLI1_27457419_Chip-Seq_LIVER_Mouse2.47692360
19GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.35823621
20CREB1_15753290_ChIP-ChIP_HEK293T_Human2.33774382
21MYC_18358816_ChIP-ChIP_MESCs_Mouse2.25417780
22HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.24156519
23CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.23792382
24IRF1_19129219_ChIP-ChIP_H3396_Human2.22176509
25CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.21394030
26CIITA_25753668_ChIP-Seq_RAJI_Human2.19698946
27SUZ12_27294783_Chip-Seq_NPCs_Mouse2.16407544
28CBX2_27304074_Chip-Seq_ESCs_Mouse2.15916265
29PCGF2_27294783_Chip-Seq_NPCs_Mouse2.11837708
30NFE2_27457419_Chip-Seq_LIVER_Mouse2.11314046
31* XRN2_22483619_ChIP-Seq_HELA_Human2.07402607
32POU5F1_16153702_ChIP-ChIP_HESCs_Human2.06919190
33* SRF_21415370_ChIP-Seq_HL-1_Mouse2.06245868
34* GABP_19822575_ChIP-Seq_HepG2_Human2.00819351
35TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.90692759
36KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.90555079
37THAP11_20581084_ChIP-Seq_MESCs_Mouse1.86609539
38IGF1R_20145208_ChIP-Seq_DFB_Human1.85736095
39SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.85037513
40PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.84429122
41JARID2_20064375_ChIP-Seq_MESCs_Mouse1.84205874
42* MYC_19030024_ChIP-ChIP_MESCs_Mouse1.82763497
43TP63_19390658_ChIP-ChIP_HaCaT_Human1.82730766
44EZH2_27304074_Chip-Seq_ESCs_Mouse1.82436627
45DCP1A_22483619_ChIP-Seq_HELA_Human1.79604290
46KDM5A_27292631_Chip-Seq_BREAST_Human1.79335102
47EZH2_27294783_Chip-Seq_NPCs_Mouse1.79103105
48POU3F2_20337985_ChIP-ChIP_501MEL_Human1.78486520
49EED_16625203_ChIP-ChIP_MESCs_Mouse1.78041981
50VDR_21846776_ChIP-Seq_THP-1_Human1.76645520
51TTF2_22483619_ChIP-Seq_HELA_Human1.75265145
52ELF1_17652178_ChIP-ChIP_JURKAT_Human1.75150513
53RNF2_27304074_Chip-Seq_NSC_Mouse1.73267149
54EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.72850081
55STAT3_18555785_Chip-Seq_ESCs_Mouse1.71122981
56HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.70369140
57SUZ12_18555785_Chip-Seq_ESCs_Mouse1.69714300
58EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.67484849
59BP1_19119308_ChIP-ChIP_Hs578T_Human1.66987622
60* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.66103292
61NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.65293446
62EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.65143814
63NANOG_18555785_Chip-Seq_ESCs_Mouse1.64841687
64P53_22387025_ChIP-Seq_ESCs_Mouse1.64759099
65NOTCH1_21737748_ChIP-Seq_TLL_Human1.62972639
66SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.62756142
67MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.62273051
68NMYC_18555785_Chip-Seq_ESCs_Mouse1.61263617
69TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.60268990
70E2F1_18555785_Chip-Seq_ESCs_Mouse1.59855936
71TAF15_26573619_Chip-Seq_HEK293_Human1.58796497
72FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.57795323
73P300_18555785_Chip-Seq_ESCs_Mouse1.57136583
74RUNX1_27457419_Chip-Seq_LIVER_Mouse1.55772198
75CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.53911219
76MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.53637708
77* ELK1_19687146_ChIP-ChIP_HELA_Human1.50519577
78E2F1_21310950_ChIP-Seq_MCF-7_Human1.50258594
79* MYC_19079543_ChIP-ChIP_MESCs_Mouse1.50168953
80PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.48641312
81FUS_26573619_Chip-Seq_HEK293_Human1.48640983
82HOXB4_20404135_ChIP-ChIP_EML_Mouse1.46858643
83ZFX_18555785_Chip-Seq_ESCs_Mouse1.46750376
84* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.45720834
85YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.44265203
86OCT4_18555785_Chip-Seq_ESCs_Mouse1.44177606
87CMYC_18555785_Chip-Seq_ESCs_Mouse1.43763649
88SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.43463055
89SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.42625333
90KLF4_18555785_Chip-Seq_ESCs_Mouse1.42017341
91EWS_26573619_Chip-Seq_HEK293_Human1.41353012
92* BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.41321746
93MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.40717324
94CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.40656935
95SOX2_18555785_Chip-Seq_ESCs_Mouse1.39901926
96MAF_26560356_Chip-Seq_TH2_Human1.39579181
97P300_19829295_ChIP-Seq_ESCs_Human1.39287425
98CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.38726311
99POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.38203480
100TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.37610903
101ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.35811556
102PU1_27457419_Chip-Seq_LIVER_Mouse1.34699938
103ESRRB_18555785_Chip-Seq_ESCs_Mouse1.33947926
104MYC_18940864_ChIP-ChIP_HL60_Human1.32677578
105SMAD1_18555785_Chip-Seq_ESCs_Mouse1.31943031
106CTCF_18555785_Chip-Seq_ESCs_Mouse1.31917149
107TAL1_26923725_Chip-Seq_HPCs_Mouse1.31853709
108RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.31480874
109JARID2_20075857_ChIP-Seq_MESCs_Mouse1.31092358
110* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.29494582
111ER_23166858_ChIP-Seq_MCF-7_Human1.28682702
112CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.28596639
113IRF8_22096565_ChIP-ChIP_GC-B_Human1.27774932
114* BCL6_27268052_Chip-Seq_Bcells_Human1.26455203
115VDR_22108803_ChIP-Seq_LS180_Human1.26185701
116CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.24572633
117EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.24261685
118ZNF274_21170338_ChIP-Seq_K562_Hela1.23774924
119PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.23424880
120CRX_20693478_ChIP-Seq_RETINA_Mouse1.22494175
121PADI4_21655091_ChIP-ChIP_MCF-7_Human1.22420826
122SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.20948695
123PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.20889168
124EZH2_27294783_Chip-Seq_ESCs_Mouse1.20692014
125SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.20366122
126* SPI1_23547873_ChIP-Seq_NB4_Human1.16959683
127* FOXP1_21924763_ChIP-Seq_HESCs_Human1.16740733
128SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.16040106
129RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.15612285
130ERG_20887958_ChIP-Seq_HPC-7_Mouse1.15477407
131* JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.15157605
132SALL1_21062744_ChIP-ChIP_HESCs_Human1.14115459
133SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.12677304
134OCT4_21477851_ChIP-Seq_ESCs_Mouse1.11294872
135* FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.11162480
136MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.11029234
137NELFA_20434984_ChIP-Seq_ESCs_Mouse1.10861046
138CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.10691099
139CTBP1_25329375_ChIP-Seq_LNCAP_Human1.09054236
140SMAD_19615063_ChIP-ChIP_OVARY_Human1.07936529
141MYCN_18555785_ChIP-Seq_MESCs_Mouse1.07806867
142MYB_26560356_Chip-Seq_TH2_Human1.07069462
143MYC_22102868_ChIP-Seq_BL_Human1.06536709
144LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.06528994
145YY1_21170310_ChIP-Seq_MESCs_Mouse1.05762190
146SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.05349174
147ELF1_20517297_ChIP-Seq_JURKAT_Human1.05204858
148CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.05176713
149HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.04783576
150GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.04450857
151GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.04192394
152RNF2_18974828_ChIP-Seq_MESCs_Mouse1.03991247
153EZH2_18974828_ChIP-Seq_MESCs_Mouse1.03991247
154RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.03720427
155ERA_21632823_ChIP-Seq_H3396_Human1.03371528
156LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.02619733
157POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.02464356
158RNF2_27304074_Chip-Seq_ESCs_Mouse1.02054718
159IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.01839454
160SMAD3_21741376_ChIP-Seq_EPCs_Human1.01262171
161E2F1_20622854_ChIP-Seq_HELA_Human0.99486965
162P68_20966046_ChIP-Seq_HELA_Human0.99398575
163TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.97734754
164DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.97682082
165SUZ12_27294783_Chip-Seq_ESCs_Mouse0.97193801
166BCOR_27268052_Chip-Seq_Bcells_Human0.96878625
167SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.96845304
168PIAS1_25552417_ChIP-Seq_VCAP_Human0.96684585
169CTBP2_25329375_ChIP-Seq_LNCAP_Human0.95385557
170EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.94739469
171* MYB_26560356_Chip-Seq_TH1_Human0.94612204
172* NANOG_20526341_ChIP-Seq_ESCs_Human0.94544663
173SCL_19346495_ChIP-Seq_HPC-7_Human0.94362990
174PHF8_20622854_ChIP-Seq_HELA_Human0.94327253
175CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.93402870
176* UTX_26944678_Chip-Seq_JUKART_Human0.93084486
177KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.93074550
178KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.93074550
179KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.93074550
180CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.92879240
181EST1_17652178_ChIP-ChIP_JURKAT_Human0.92756437
182VDR_24763502_ChIP-Seq_THP-1_Human0.91728954
183SMAD4_21799915_ChIP-Seq_A2780_Human0.90659817
184YY1_22570637_ChIP-Seq_MALME-3M_Human0.89586610
185SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.88977284
186ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.87560384

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0006292_abnormal_olfactory_placode4.34733791
2MP0003136_yellow_coat_color4.01618585
3MP0001188_hyperpigmentation3.92379832
4MP0005409_darkened_coat_color3.26962227
5MP0000566_synostosis3.04163896
6MP0004381_abnormal_hair_follicle2.81084289
7MP0009379_abnormal_foot_pigmentation2.70226370
8MP0001986_abnormal_taste_sensitivity2.47076400
9MP0003077_abnormal_cell_cycle2.40481607
10MP0000015_abnormal_ear_pigmentation2.28664817
11MP0003806_abnormal_nucleotide_metabolis2.21837993
12MP0002102_abnormal_ear_morphology2.17946793
13MP0005410_abnormal_fertilization2.14866604
14MP0002638_abnormal_pupillary_reflex2.09722727
15MP0002653_abnormal_ependyma_morphology2.02307498
16MP0003880_abnormal_central_pattern1.99960915
17MP0005174_abnormal_tail_pigmentation1.97267404
18MP0006036_abnormal_mitochondrial_physio1.96549786
19MP0002277_abnormal_respiratory_mucosa1.94656508
20MP0002396_abnormal_hematopoietic_system1.89861887
21MP0008007_abnormal_cellular_replicative1.89825521
22MP0008058_abnormal_DNA_repair1.85046478
23MP0004742_abnormal_vestibular_system1.79950758
24MP0005423_abnormal_somatic_nervous1.79523444
25MP0005551_abnormal_eye_electrophysiolog1.77310936
26MP0005171_absent_coat_pigmentation1.73442782
27MP0004957_abnormal_blastocyst_morpholog1.72532620
28MP0008260_abnormal_autophagy1.65346491
29MP0003787_abnormal_imprinting1.65013820
30MP0005645_abnormal_hypothalamus_physiol1.64113148
31MP0000372_irregular_coat_pigmentation1.61363853
32MP0002938_white_spotting1.61241423
33MP0001929_abnormal_gametogenesis1.59084147
34MP0006072_abnormal_retinal_apoptosis1.59028693
35MP0005379_endocrine/exocrine_gland_phen1.58816983
36MP0005075_abnormal_melanosome_morpholog1.57233916
37MP0005253_abnormal_eye_physiology1.50198822
38MP0004142_abnormal_muscle_tone1.48830125
39MP0000026_abnormal_inner_ear1.47223923
40MP0008057_abnormal_DNA_replication1.45565046
41MP0000703_abnormal_thymus_morphology1.43656273
42MP0005646_abnormal_pituitary_gland1.43628569
43MP0003938_abnormal_ear_development1.43573966
44MP0000049_abnormal_middle_ear1.43121927
45MP0003698_abnormal_male_reproductive1.39384090
46MP0002876_abnormal_thyroid_physiology1.36096725
47MP0002751_abnormal_autonomic_nervous1.34449926
48MP0001486_abnormal_startle_reflex1.32712041
49MP0002095_abnormal_skin_pigmentation1.31375735
50MP0002249_abnormal_larynx_morphology1.31290014
51MP0002398_abnormal_bone_marrow1.30987822
52MP0008995_early_reproductive_senescence1.30766863
53MP0006035_abnormal_mitochondrial_morpho1.30174712
54MP0001800_abnormal_humoral_immune1.29194749
55MP0006276_abnormal_autonomic_nervous1.27192032
56MP0003941_abnormal_skin_development1.26864587
57MP0002163_abnormal_gland_morphology1.24430512
58MP0000631_abnormal_neuroendocrine_gland1.23995974
59MP0001764_abnormal_homeostasis1.23227147
60MP0001529_abnormal_vocalization1.22226279
61MP0001905_abnormal_dopamine_level1.21581286
62MP0008789_abnormal_olfactory_epithelium1.20251571
63MP0001963_abnormal_hearing_physiology1.19993487
64MP0003786_premature_aging1.19273154
65MP0005397_hematopoietic_system_phenotyp1.18669241
66MP0001545_abnormal_hematopoietic_system1.18669241
67MP0003646_muscle_fatigue1.18560354
68MP0002019_abnormal_tumor_incidence1.18486596
69MP0000689_abnormal_spleen_morphology1.18124038
70MP0001145_abnormal_male_reproductive1.16323892
71MP0009278_abnormal_bone_marrow1.15357491
72MP0003724_increased_susceptibility_to1.14765470
73MP0004133_heterotaxia1.12004204
74MP0002132_abnormal_respiratory_system1.10573654
75MP0005084_abnormal_gallbladder_morpholo1.10418475
76MP0000681_abnormal_thyroid_gland1.10417326
77MP0000678_abnormal_parathyroid_gland1.09236909
78MP0002722_abnormal_immune_system1.08570079
79MP0003172_abnormal_lysosome_physiology1.08458721
80MP0003186_abnormal_redox_activity1.08452542
81MP0003718_maternal_effect1.06331562
82MP0002177_abnormal_outer_ear1.06093658
83MP0000653_abnormal_sex_gland1.05857938
84MP0000716_abnormal_immune_system1.03856313
85MP0002752_abnormal_somatic_nervous1.03322823
86MP0002420_abnormal_adaptive_immunity1.03288827
87MP0000313_abnormal_cell_death1.01663609
88MP0001819_abnormal_immune_cell1.01380602
89MP0008872_abnormal_physiological_respon1.00605284
90MP0001485_abnormal_pinna_reflex0.98069474
91MP0005499_abnormal_olfactory_system0.97568480
92MP0005394_taste/olfaction_phenotype0.97568480
93MP0002160_abnormal_reproductive_system0.97552133
94MP0003315_abnormal_perineum_morphology0.97312428
95MP0002723_abnormal_immune_serum0.96927708
96MP0002429_abnormal_blood_cell0.96425349
97MP0008877_abnormal_DNA_methylation0.95421679
98MP0002272_abnormal_nervous_system0.95047254
99MP0003763_abnormal_thymus_physiology0.94164949
100MP0003693_abnormal_embryo_hatching0.92477853
101MP0005451_abnormal_body_composition0.91859188
102MP0009046_muscle_twitch0.91543632
103MP0001346_abnormal_lacrimal_gland0.90264125
104MP0000762_abnormal_tongue_morphology0.89850667
105MP0005377_hearing/vestibular/ear_phenot0.89615213
106MP0003878_abnormal_ear_physiology0.89615213
107MP0010094_abnormal_chromosome_stability0.88515189
108MP0001502_abnormal_circadian_rhythm0.87427469
109MP0002557_abnormal_social/conspecific_i0.86370417
110MP0001968_abnormal_touch/_nociception0.86195605
111MP0009333_abnormal_splenocyte_physiolog0.85198625
112MP0001293_anophthalmia0.85089805
113MP0002067_abnormal_sensory_capabilities0.85009820
114MP0002452_abnormal_antigen_presenting0.84887215
115MP0001835_abnormal_antigen_presentation0.84833492
116MP0002735_abnormal_chemical_nociception0.84428412
117MP0000613_abnormal_salivary_gland0.84205965
118MP0002928_abnormal_bile_duct0.83471952
119MP0009250_abnormal_appendicular_skeleto0.83037171
120MP0001919_abnormal_reproductive_system0.82451278
121MP0003943_abnormal_hepatobiliary_system0.80202991
122MP0003950_abnormal_plasma_membrane0.79497636
123MP0000383_abnormal_hair_follicle0.79291955
124MP0003937_abnormal_limbs/digits/tail_de0.79132973
125MP0000778_abnormal_nervous_system0.78957350
126MP0001119_abnormal_female_reproductive0.78725618
127MP0005389_reproductive_system_phenotype0.78088663
128MP0000371_diluted_coat_color0.77853902
129MP0003011_delayed_dark_adaptation0.77374687
130MP0001984_abnormal_olfaction0.77308608
131MP0002405_respiratory_system_inflammati0.76973820
132MP0005025_abnormal_response_to0.76939857
133MP0001324_abnormal_eye_pigmentation0.75552293
134MP0003111_abnormal_nucleus_morphology0.75251122
135MP0005391_vision/eye_phenotype0.75080060
136MP0009745_abnormal_behavioral_response0.74273410
137MP0005195_abnormal_posterior_eye0.73614117
138MP0005671_abnormal_response_to0.73270409
139MP0002184_abnormal_innervation0.71865513
140MP0002736_abnormal_nociception_after0.71751275
141MP0000490_abnormal_crypts_of0.71615812
142MP0002148_abnormal_hypersensitivity_rea0.70828038
143MP0005266_abnormal_metabolism0.70794599
144MP0000470_abnormal_stomach_morphology0.69849450
145MP0010386_abnormal_urinary_bladder0.69462186
146MP0008932_abnormal_embryonic_tissue0.69398960
147MP0002210_abnormal_sex_determination0.68475781
148MP0005395_other_phenotype0.66767078
149MP0000685_abnormal_immune_system0.65696751
150MP0009765_abnormal_xenobiotic_induced0.64706669
151MP0003195_calcinosis0.64381382
152MP0002161_abnormal_fertility/fecundity0.64341122
153MP0005000_abnormal_immune_tolerance0.63833594
154MP0008873_increased_physiological_sensi0.63344501

Predicted human phenotypes

RankGene SetZ-score
1Chromosomal breakage induced by crosslinking agents (HP:0003221)5.05248729
2Chromsome breakage (HP:0040012)4.53106089
3Abnormality of the renal collecting system (HP:0004742)3.48576798
4Duplicated collecting system (HP:0000081)3.46411670
5Acute necrotizing encephalopathy (HP:0006965)3.44493312
6Mitochondrial inheritance (HP:0001427)3.37943239
7Abnormal number of erythroid precursors (HP:0012131)3.37781389
8Abnormal mitochondria in muscle tissue (HP:0008316)3.26589612
9Hepatocellular necrosis (HP:0001404)3.23825870
10Septo-optic dysplasia (HP:0100842)3.22176609
11Absent rod-and cone-mediated responses on ERG (HP:0007688)3.20858181
12Abnormality of cells of the erythroid lineage (HP:0012130)3.10941302
13Type I transferrin isoform profile (HP:0003642)3.09916947
14Congenital stationary night blindness (HP:0007642)3.08196741
15Increased CSF lactate (HP:0002490)3.05388903
16Acute encephalopathy (HP:0006846)3.02706426
17Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)3.00465556
18Increased hepatocellular lipid droplets (HP:0006565)2.97203069
19Decreased central vision (HP:0007663)2.96823013
20Methylmalonic aciduria (HP:0012120)2.95769049
21Absent thumb (HP:0009777)2.92026267
22Abnormality of the preputium (HP:0100587)2.89294270
23True hermaphroditism (HP:0010459)2.88076628
24Lipid accumulation in hepatocytes (HP:0006561)2.86568261
25Panhypogammaglobulinemia (HP:0003139)2.85127496
26Aplasia/Hypoplasia of the uvula (HP:0010293)2.76678188
27Meckel diverticulum (HP:0002245)2.76645431
28Rectovaginal fistula (HP:0000143)2.75017405
29Rectal fistula (HP:0100590)2.75017405
30Hepatic necrosis (HP:0002605)2.74324418
31Attenuation of retinal blood vessels (HP:0007843)2.67459853
32Abnormality of the ileum (HP:0001549)2.67349736
33Abnormality of the labia minora (HP:0012880)2.64766171
34Abnormal rod and cone electroretinograms (HP:0008323)2.63512790
35Increased intramyocellular lipid droplets (HP:0012240)2.62279800
36Progressive macrocephaly (HP:0004481)2.59653754
37Decreased activity of mitochondrial respiratory chain (HP:0008972)2.59319182
38Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.59319182
39Pendular nystagmus (HP:0012043)2.56799909
40Progressive microcephaly (HP:0000253)2.56787575
41Reticulocytopenia (HP:0001896)2.53080978
42Intestinal fistula (HP:0100819)2.51802114
43Absent septum pellucidum (HP:0001331)2.51605401
44Increased muscle lipid content (HP:0009058)2.46149210
45Abnormality of DNA repair (HP:0003254)2.44738849
46Methylmalonic acidemia (HP:0002912)2.39710298
47Birth length less than 3rd percentile (HP:0003561)2.38963544
48Abnormality of the septum pellucidum (HP:0007375)2.37363535
49Pancytopenia (HP:0001876)2.36528304
50Increased serum lactate (HP:0002151)2.35764737
51Clubbing of toes (HP:0100760)2.35553566
52Optic nerve hypoplasia (HP:0000609)2.35291249
53Pallor (HP:0000980)2.34695598
54Dynein arm defect of respiratory motile cilia (HP:0012255)2.34530220
55Absent/shortened dynein arms (HP:0200106)2.34530220
56Parakeratosis (HP:0001036)2.34399975
57Sloping forehead (HP:0000340)2.33539512
58Abnormal ciliary motility (HP:0012262)2.32130822
59Congenital sensorineural hearing impairment (HP:0008527)2.31917234
60Duplication of thumb phalanx (HP:0009942)2.30829411
61Pancreatic fibrosis (HP:0100732)2.29862600
62Reduced antithrombin III activity (HP:0001976)2.29387433
633-Methylglutaconic aciduria (HP:0003535)2.28698142
64Abnormality of chromosome stability (HP:0003220)2.27343776
65Chronic hepatic failure (HP:0100626)2.24515121
66Patellar aplasia (HP:0006443)2.23937188
67Rib fusion (HP:0000902)2.23921709
68Respiratory difficulties (HP:0002880)2.23867809
69Macrocytic anemia (HP:0001972)2.23291298
70Severe visual impairment (HP:0001141)2.22362944
71Myelodysplasia (HP:0002863)2.22247516
72Febrile seizures (HP:0002373)2.20565124
73Tubulointerstitial nephritis (HP:0001970)2.20529567
74Hypoplasia of the pons (HP:0012110)2.20290747
75Aplasia/Hypoplasia of the fovea (HP:0008060)2.19441429
76Hypoplasia of the fovea (HP:0007750)2.19441429
77Pancreatic cysts (HP:0001737)2.19275917
78Severe combined immunodeficiency (HP:0004430)2.17906558
79Exertional dyspnea (HP:0002875)2.15694190
80Dicarboxylic aciduria (HP:0003215)2.14911541
81Abnormality of dicarboxylic acid metabolism (HP:0010995)2.14911541
82Abnormal respiratory motile cilium morphology (HP:0005938)2.14249353
83Abnormal respiratory epithelium morphology (HP:0012253)2.14249353
84Upper limb muscle weakness (HP:0003484)2.13346403
85Aplasia cutis congenita (HP:0001057)2.13326504
86Vaginal fistula (HP:0004320)2.12354172
87Cerebral edema (HP:0002181)2.11718449
88Triphalangeal thumb (HP:0001199)2.11658101
89IgM deficiency (HP:0002850)2.09165265
90Lactic acidosis (HP:0003128)2.08442402
91Colon cancer (HP:0003003)2.08424426
92Decreased electroretinogram (ERG) amplitude (HP:0000654)2.07871609
93Microvesicular hepatic steatosis (HP:0001414)2.07866053
94Squamous cell carcinoma (HP:0002860)2.07294989
95White forelock (HP:0002211)2.06997089
96Increased corneal curvature (HP:0100692)2.06818796
97Keratoconus (HP:0000563)2.06818796
98Patchy hypopigmentation of hair (HP:0011365)2.06387902
99Dyschromatopsia (HP:0007641)2.06384015
100Aplastic anemia (HP:0001915)2.06189673
101Hypothermia (HP:0002045)2.05376757
102Aplasia/Hypoplasia of the patella (HP:0006498)2.05205341
103Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.04333002
104Abnormality of the pons (HP:0007361)2.02222450
105Facial hemangioma (HP:0000329)2.01746152
106Prostate neoplasm (HP:0100787)2.01076950
107Abnormality of secondary sexual hair (HP:0009888)2.00339337
108Abnormality of the axillary hair (HP:0100134)2.00339337
109Nephroblastoma (Wilms tumor) (HP:0002667)2.00204229
110Aplasia/Hypoplasia of the sacrum (HP:0008517)2.00186356
111Abnormality of renal resorption (HP:0011038)1.99725102
112Nasolacrimal duct obstruction (HP:0000579)1.97681549
113Abnormality of homocysteine metabolism (HP:0010919)1.94858113
114Homocystinuria (HP:0002156)1.94858113
115Hyperglycinemia (HP:0002154)1.94653019
116Male pseudohermaphroditism (HP:0000037)1.94139486
117Thyroid-stimulating hormone excess (HP:0002925)1.93778949
118Cerebral hypomyelination (HP:0006808)1.93226220
119Stomach cancer (HP:0012126)1.91768953
120Median cleft lip (HP:0000161)1.91572054
121Ectopic kidney (HP:0000086)1.91511253
122Medial flaring of the eyebrow (HP:0010747)1.90500530
123Aplasia/Hypoplasia of the tibia (HP:0005772)1.90136360
124Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.89669272
125Submucous cleft hard palate (HP:0000176)1.89516480
126Conical tooth (HP:0000698)1.89363311
127Anomalous pulmonary venous return (HP:0010772)1.88138868
128Abnormality of incisor morphology (HP:0011063)1.87101579
129Bone marrow hypocellularity (HP:0005528)1.87049147
130Testicular atrophy (HP:0000029)1.87021860
131Preaxial hand polydactyly (HP:0001177)1.86939856
132Congenital nonbullous ichthyosiform erythroderma (HP:0007479)1.86805899
133Embryonal renal neoplasm (HP:0011794)1.85438608
134Dry hair (HP:0011359)1.84887764
135Cleft eyelid (HP:0000625)1.84664909
136Cystic liver disease (HP:0006706)1.84645410
137Abnormal protein glycosylation (HP:0012346)1.84461638
138Abnormal glycosylation (HP:0012345)1.84461638
139Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.84461638
140Abnormal protein N-linked glycosylation (HP:0012347)1.84461638
141Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.84409630
142Premature graying of hair (HP:0002216)1.83422692
143Combined immunodeficiency (HP:0005387)1.83133186
144Sex reversal (HP:0012245)1.82733920
145Abnormal sex determination (HP:0012244)1.82733920
146Type 2 muscle fiber atrophy (HP:0003554)1.82172363
147Lethargy (HP:0001254)1.81815073
148Recurrent fungal infections (HP:0002841)1.81635737
149Abnormal respiratory motile cilium physiology (HP:0012261)1.81018957
150Bony spicule pigmentary retinopathy (HP:0007737)1.79269507
151Osteomalacia (HP:0002749)1.77806999
152Nephrogenic diabetes insipidus (HP:0009806)1.77740782
153Supernumerary spleens (HP:0009799)1.77613336
154Aganglionic megacolon (HP:0002251)1.77316586
155Optic disc pallor (HP:0000543)1.75853558
156Renal agenesis (HP:0000104)1.75130699
157Short tibia (HP:0005736)1.74894942
158Small intestinal stenosis (HP:0012848)1.74598363
159Duodenal stenosis (HP:0100867)1.74598363
160Oligohydramnios (HP:0001562)1.73397711
161Aplasia/hypoplasia of the uterus (HP:0008684)1.72290665
162Renal Fanconi syndrome (HP:0001994)1.71849090
163Molar tooth sign on MRI (HP:0002419)1.70022630
164Abnormality of midbrain morphology (HP:0002418)1.70022630
165Congenital primary aphakia (HP:0007707)1.69432254

Predicted kinase interactions (KEA)

RankGene SetZ-score
1VRK24.60703321
2TNIK4.51870901
3CASK4.04889650
4STK163.60623064
5MKNK23.33745953
6ZAK2.71518200
7MAP4K12.55354536
8BCKDK2.38240168
9CDC72.36842870
10IRAK32.34684402
11INSRR2.30424418
12MKNK12.22673256
13SRPK12.21004798
14TAOK32.17877757
15IRAK42.14457754
16NLK2.07349502
17GRK61.86722338
18MUSK1.86446735
19MAP4K21.86069620
20MARK31.83593066
21MAP2K71.78706897
22ADRBK21.78502492
23TXK1.78155141
24PASK1.74155647
25EIF2AK21.66018466
26BRSK21.65532224
27NEK61.64721103
28BMPR1B1.60788990
29CLK11.57848614
30IRAK21.55737637
31VRK11.54899200
32PBK1.54615745
33CCNB11.52581376
34GRK11.51245068
35NUAK11.43257990
36NEK21.42617725
37TLK11.41105006
38YES11.36217032
39IRAK11.35167618
40PLK41.34226433
41WEE11.33166180
42NME21.29799075
43BLK1.25052976
44CDK31.21726182
45TESK21.19765761
46TEC1.19438863
47PKN11.17021908
48EIF2AK31.16528931
49MAP3K141.14910885
50MAPK131.11818642
51GRK71.10856027
52TNK21.08536820
53MAPK151.06982625
54AURKB1.05734705
55BRD41.04727815
56ACVR1B1.01298733
57TYK20.98256446
58BUB10.95406815
59PDK20.90867158
60PRPF4B0.90834543
61BMPR20.89869895
62SYK0.86853683
63MAPKAPK50.86572385
64MAP2K30.85251577
65EIF2AK10.84039700
66AKT30.83304607
67STK390.82866062
68BRSK10.80575042
69WNK30.80080304
70OXSR10.79841696
71TAF10.79119240
72FRK0.79057610
73DYRK20.78320245
74IKBKB0.73664051
75CDK40.72734157
76KIT0.71707436
77FES0.71248188
78KDR0.70979635
79CHEK10.70975873
80CDK190.69893761
81SIK30.69066731
82DYRK30.68947754
83ATM0.68700631
84MAP3K100.65327453
85MST40.65191972
86RPS6KA50.59955124
87TRIM280.59897338
88CDK20.58306730
89CAMK10.57808680
90PINK10.57140215
91TTK0.56976328
92PRKD20.54981628
93PIM10.54968936
94PIM20.54298216
95UHMK10.54086982
96PRKCQ0.53953521
97BCR0.53287030
98CAMK2B0.52740362
99BTK0.52714794
100ATR0.52664282
101STK38L0.52391054
102CDK80.52008730
103CHEK20.51435847
104DYRK1B0.51305728
105MAP3K110.50381458
106MAP2K60.48821304
107LYN0.47955985
108ITK0.47260056
109PIK3CA0.47088298
110CAMK2D0.46880394
111DYRK1A0.46370193
112CDK10.46159250
113NME10.45446372
114STK40.44797707
115SIK20.42832576
116MARK10.42149752
117PRKCE0.41890895
118CDK70.41711044
119PLK10.41064223
120NTRK30.40211581
121AURKA0.40187822
122DMPK0.40133874
123TBK10.39147211
124MAP3K130.38643606
125CSNK1G30.38427063
126WNK40.37999565
127EPHA20.37282540
128OBSCN0.36955346
129HCK0.36891470
130LCK0.35621387
131PLK30.35605940
132STK100.35472428
133CSNK2A10.35269481
134IKBKE0.35200673
135PRKG10.33609447
136CSNK1G10.33512920
137BRAF0.33326950
138SGK4940.33184669
139SGK2230.33184669
140CAMK2A0.31408665
141PNCK0.30588688
142MARK20.29424343
143HIPK20.28501300
144PIK3CG0.27904873
145SGK20.26907409
146CSNK1A1L0.26582593
147CSNK2A20.26567565
148PRKACA0.25720820

Predicted pathways (KEGG)

RankGene SetZ-score
1Phototransduction_Homo sapiens_hsa047443.08166248
2Fanconi anemia pathway_Homo sapiens_hsa034602.86835486
3Homologous recombination_Homo sapiens_hsa034402.67141643
4Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.58057364
5Ribosome_Homo sapiens_hsa030102.50646550
6RNA polymerase_Homo sapiens_hsa030202.17820553
7Basal transcription factors_Homo sapiens_hsa030222.00036318
8Sulfur relay system_Homo sapiens_hsa041221.91656727
9Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.89844794
10Protein export_Homo sapiens_hsa030601.87972233
11Sphingolipid metabolism_Homo sapiens_hsa006001.82310987
12Nicotine addiction_Homo sapiens_hsa050331.80985701
13DNA replication_Homo sapiens_hsa030301.77472051
14Non-homologous end-joining_Homo sapiens_hsa034501.76647135
15Oxidative phosphorylation_Homo sapiens_hsa001901.71343276
16Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.67823872
17Mismatch repair_Homo sapiens_hsa034301.65870253
18Arachidonic acid metabolism_Homo sapiens_hsa005901.59745755
19Pyrimidine metabolism_Homo sapiens_hsa002401.54183908
20Graft-versus-host disease_Homo sapiens_hsa053321.50336352
21Ether lipid metabolism_Homo sapiens_hsa005651.50175735
22One carbon pool by folate_Homo sapiens_hsa006701.45916369
23Nucleotide excision repair_Homo sapiens_hsa034201.44861297
24Autoimmune thyroid disease_Homo sapiens_hsa053201.44494334
25Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.42193855
26Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.38162117
27Spliceosome_Homo sapiens_hsa030401.38150165
28Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.35348129
29Base excision repair_Homo sapiens_hsa034101.32672807
30Purine metabolism_Homo sapiens_hsa002301.26549198
31Linoleic acid metabolism_Homo sapiens_hsa005911.25575377
32Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.25060155
33Primary immunodeficiency_Homo sapiens_hsa053401.22942740
34Allograft rejection_Homo sapiens_hsa053301.21609319
35Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.19728078
36Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.16014342
37Proteasome_Homo sapiens_hsa030501.15730343
38Other glycan degradation_Homo sapiens_hsa005111.11873679
39SNARE interactions in vesicular transport_Homo sapiens_hsa041301.10218575
40Parkinsons disease_Homo sapiens_hsa050121.09501670
41Hematopoietic cell lineage_Homo sapiens_hsa046401.09057090
42NF-kappa B signaling pathway_Homo sapiens_hsa040641.07356327
43RNA degradation_Homo sapiens_hsa030181.07300588
44Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.05734795
45Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.05647668
46Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.04437375
47Intestinal immune network for IgA production_Homo sapiens_hsa046721.04193517
48Huntingtons disease_Homo sapiens_hsa050161.03998884
49Asthma_Homo sapiens_hsa053101.03520044
50alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.02600808
51Taste transduction_Homo sapiens_hsa047421.00302495
52Serotonergic synapse_Homo sapiens_hsa047260.98878721
53Selenocompound metabolism_Homo sapiens_hsa004500.98263132
54Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.94228155
55Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.93858157
56Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.93373451
57Alzheimers disease_Homo sapiens_hsa050100.88868469
58Rheumatoid arthritis_Homo sapiens_hsa053230.83888315
59Butanoate metabolism_Homo sapiens_hsa006500.83491476
60Propanoate metabolism_Homo sapiens_hsa006400.83084110
61Fatty acid elongation_Homo sapiens_hsa000620.82893696
62RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.82247573
63Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.81629078
64Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.80770148
65Morphine addiction_Homo sapiens_hsa050320.80232595
66Vitamin digestion and absorption_Homo sapiens_hsa049770.74262244
67p53 signaling pathway_Homo sapiens_hsa041150.70194603
68Glutathione metabolism_Homo sapiens_hsa004800.70103770
69Basal cell carcinoma_Homo sapiens_hsa052170.69698236
70Fatty acid degradation_Homo sapiens_hsa000710.68445867
71Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.67486436
72Steroid biosynthesis_Homo sapiens_hsa001000.67232972
73Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.66118765
74Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.65382275
75Transcriptional misregulation in cancer_Homo sapiens_hsa052020.65177656
76Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.64667574
77Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.64656116
78Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.64540267
79Measles_Homo sapiens_hsa051620.63891937
80Herpes simplex infection_Homo sapiens_hsa051680.63737727
81Peroxisome_Homo sapiens_hsa041460.63122730
82Cell cycle_Homo sapiens_hsa041100.62160536
83Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.61530081
84Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.61341390
85Lysine degradation_Homo sapiens_hsa003100.57738560
86Steroid hormone biosynthesis_Homo sapiens_hsa001400.56675063
87Regulation of autophagy_Homo sapiens_hsa041400.55966261
88Vitamin B6 metabolism_Homo sapiens_hsa007500.55700817
89NOD-like receptor signaling pathway_Homo sapiens_hsa046210.55547076
90Antigen processing and presentation_Homo sapiens_hsa046120.55351488
91Cysteine and methionine metabolism_Homo sapiens_hsa002700.55279690
92Maturity onset diabetes of the young_Homo sapiens_hsa049500.54910757
93Wnt signaling pathway_Homo sapiens_hsa043100.54617281
94Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.51495394
95Glutamatergic synapse_Homo sapiens_hsa047240.51157909
96mRNA surveillance pathway_Homo sapiens_hsa030150.50058859
97Malaria_Homo sapiens_hsa051440.49774197
98Olfactory transduction_Homo sapiens_hsa047400.48663846
99Jak-STAT signaling pathway_Homo sapiens_hsa046300.47897868
100Drug metabolism - other enzymes_Homo sapiens_hsa009830.46012396
101Tryptophan metabolism_Homo sapiens_hsa003800.45896247
102RNA transport_Homo sapiens_hsa030130.45009474
103Axon guidance_Homo sapiens_hsa043600.43074237
104Type I diabetes mellitus_Homo sapiens_hsa049400.40722272
105Metabolic pathways_Homo sapiens_hsa011000.39552967
106Pyruvate metabolism_Homo sapiens_hsa006200.39315805
107Retinol metabolism_Homo sapiens_hsa008300.38896097
108Calcium signaling pathway_Homo sapiens_hsa040200.38521918
109African trypanosomiasis_Homo sapiens_hsa051430.37857270
110Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.37266467
111Collecting duct acid secretion_Homo sapiens_hsa049660.37141797
112Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.36973396
113Circadian rhythm_Homo sapiens_hsa047100.36874570
114Hedgehog signaling pathway_Homo sapiens_hsa043400.36384183
115Folate biosynthesis_Homo sapiens_hsa007900.36263123
116Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.35938439
117Glycerophospholipid metabolism_Homo sapiens_hsa005640.35823384
118Chemical carcinogenesis_Homo sapiens_hsa052040.34668096
119Alcoholism_Homo sapiens_hsa050340.34649938
120Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.34245753
121Systemic lupus erythematosus_Homo sapiens_hsa053220.33706165
122Cardiac muscle contraction_Homo sapiens_hsa042600.33344493
123GABAergic synapse_Homo sapiens_hsa047270.30928025
124Epstein-Barr virus infection_Homo sapiens_hsa051690.30753125
125Ovarian steroidogenesis_Homo sapiens_hsa049130.30640747
126Cocaine addiction_Homo sapiens_hsa050300.30296446
127Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.29142028
128Primary bile acid biosynthesis_Homo sapiens_hsa001200.27890354
1292-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.27819155
130Nitrogen metabolism_Homo sapiens_hsa009100.27469170
131Oocyte meiosis_Homo sapiens_hsa041140.27256825
132Glycerolipid metabolism_Homo sapiens_hsa005610.26427587
133N-Glycan biosynthesis_Homo sapiens_hsa005100.25860247
134Fatty acid metabolism_Homo sapiens_hsa012120.23695217

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