ITGA1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes the alpha 1 subunit of integrin receptors. This protein heterodimerizes with the beta 1 subunit to form a cell-surface receptor for collagen and laminin. The heterodimeric receptor is involved in cell-cell adhesion and may play a role in inflammation and fibrosis. The alpha 1 subunit contains an inserted (I) von Willebrand factor type I domain which is thought to be involved in collagen binding. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1lymph vessel development (GO:0001945)4.76537201
2vascular endothelial growth factor signaling pathway (GO:0038084)4.67598072
3retina vasculature morphogenesis in camera-type eye (GO:0061299)4.13225988
4low-density lipoprotein particle clearance (GO:0034383)3.98915622
5negative regulation of protein activation cascade (GO:2000258)3.92474853
6negative regulation of complement activation (GO:0045916)3.75164175
7cellular response to vascular endothelial growth factor stimulus (GO:0035924)3.64474020
8glomerular filtration (GO:0003094)3.63232197
9endothelium development (GO:0003158)3.59097667
10basement membrane organization (GO:0071711)3.56621089
11chondrocyte proliferation (GO:0035988)3.53130686
12fatty acid transmembrane transport (GO:1902001)3.52293866
13endothelial cell morphogenesis (GO:0001886)3.45908176
14transcytosis (GO:0045056)3.45863358
15renal filtration (GO:0097205)3.45702720
16glucocorticoid biosynthetic process (GO:0006704)3.44931938
17glomerular basement membrane development (GO:0032836)3.44213382
18regulation of apoptotic cell clearance (GO:2000425)3.41779702
19peptidyl-glutamic acid carboxylation (GO:0017187)3.32015264
20protein carboxylation (GO:0018214)3.32015264
21regulation of cholesterol storage (GO:0010885)3.30411968
22blood vessel maturation (GO:0001955)3.29392983
23endodermal cell differentiation (GO:0035987)3.28763075
24alpha-linolenic acid metabolic process (GO:0036109)3.28316069
25surfactant homeostasis (GO:0043129)3.27029110
26negative regulation of fibrinolysis (GO:0051918)3.26721961
27regulation of protein activation cascade (GO:2000257)3.26284733
28regulation of endothelial cell differentiation (GO:0045601)3.26224400
29fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.25141522
30lysine metabolic process (GO:0006553)3.25099105
31lysine catabolic process (GO:0006554)3.25099105
32positive regulation of endothelial cell apoptotic process (GO:2000353)3.22321647
33regulation of complement activation (GO:0030449)3.21573828
34collagen fibril organization (GO:0030199)3.21290650
35lymphangiogenesis (GO:0001946)3.20409634
36cell adhesion mediated by integrin (GO:0033627)3.19566894
37negative regulation of fatty acid transport (GO:2000192)3.17257334
38tonic smooth muscle contraction (GO:0014820)3.16992627
39cell migration involved in heart development (GO:0060973)3.14896971
40complement activation, alternative pathway (GO:0006957)3.14073889
41plasma lipoprotein particle clearance (GO:0034381)3.07657097
42positive regulation of vasculogenesis (GO:2001214)3.07309552
43positive regulation of fatty acid beta-oxidation (GO:0032000)3.04691376
44sequestering of extracellular ligand from receptor (GO:0035581)3.04134049
45cell migration involved in sprouting angiogenesis (GO:0002042)2.97399789
46ovulation from ovarian follicle (GO:0001542)2.97329968
47patterning of blood vessels (GO:0001569)2.97245342
48erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)2.97167809
49L-phenylalanine catabolic process (GO:0006559)2.97167809
50blood vessel endothelial cell migration (GO:0043534)2.96547621
51fatty acid beta-oxidation (GO:0006635)2.92891169
52positive regulation of fatty acid oxidation (GO:0046321)2.91780134
53regulation of vasculogenesis (GO:2001212)2.89945316
54carnitine shuttle (GO:0006853)2.88003586
55complement activation, classical pathway (GO:0006958)2.86337938
56endocardial cushion morphogenesis (GO:0003203)2.85911514
57phagocytosis, recognition (GO:0006910)2.85790789
58glyoxylate metabolic process (GO:0046487)2.85657690
59homocysteine metabolic process (GO:0050667)2.85392372
60phospholipid homeostasis (GO:0055091)2.84113370
61regulation of fibrinolysis (GO:0051917)2.83632988
62regulation of sequestering of triglyceride (GO:0010889)2.82750908
63erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)2.82657713
64L-phenylalanine metabolic process (GO:0006558)2.82657713
65regulation of plasminogen activation (GO:0010755)2.82144210
66triglyceride-rich lipoprotein particle remodeling (GO:0034370)2.79507292
67regulation of triglyceride catabolic process (GO:0010896)2.74316315
68protein activation cascade (GO:0072376)2.73737356
69triglyceride homeostasis (GO:0070328)2.72542312
70acylglycerol homeostasis (GO:0055090)2.72542312
71endocardial cushion development (GO:0003197)2.72269544
72aromatic amino acid family catabolic process (GO:0009074)2.72190777
73morphogenesis of an endothelium (GO:0003159)2.71638110
74endothelial tube morphogenesis (GO:0061154)2.71638110
75kidney mesenchyme development (GO:0072074)2.71591687
76fatty acid oxidation (GO:0019395)2.71528179
77keratan sulfate catabolic process (GO:0042340)2.70379662
78smooth muscle tissue development (GO:0048745)2.69806776
79negative regulation of hemostasis (GO:1900047)2.66446174
80negative regulation of blood coagulation (GO:0030195)2.66446174
81lipid oxidation (GO:0034440)2.66258653
82regulation of endothelial cell apoptotic process (GO:2000351)2.66145357
83skin morphogenesis (GO:0043589)2.65559008
84wound healing, spreading of epidermal cells (GO:0035313)2.64262756
85growth hormone receptor signaling pathway (GO:0060396)2.63673826
86protein heterotrimerization (GO:0070208)2.63311148
87sulfur amino acid catabolic process (GO:0000098)2.63223977
88positive regulation of osteoblast proliferation (GO:0033690)2.63109098
89lung vasculature development (GO:0060426)2.62827264
90vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.62827139
91cGMP-mediated signaling (GO:0019934)2.62716951
92amino-acid betaine metabolic process (GO:0006577)2.62564455
93negative regulation of macrophage derived foam cell differentiation (GO:0010745)2.61767659
94positive regulation of smooth muscle cell migration (GO:0014911)2.61508138
95regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.61496324
96glucocorticoid metabolic process (GO:0008211)2.61385429
97negative regulation of humoral immune response (GO:0002921)2.60420689
98positive regulation of blood coagulation (GO:0030194)2.59524632
99positive regulation of hemostasis (GO:1900048)2.59524632
100complement activation (GO:0006956)2.59502859
101substrate adhesion-dependent cell spreading (GO:0034446)2.59087911
102urea cycle (GO:0000050)2.58943397
103urea metabolic process (GO:0019627)2.58943397
104regulation of extracellular matrix disassembly (GO:0010715)2.58940684
105positive regulation of lipid catabolic process (GO:0050996)2.58624180
106cysteine metabolic process (GO:0006534)2.58106536
107apoptotic cell clearance (GO:0043277)2.58006932
108endocrine hormone secretion (GO:0060986)2.57966432
109valine metabolic process (GO:0006573)2.55535152
110heart trabecula formation (GO:0060347)2.54975730
111atrioventricular valve morphogenesis (GO:0003181)2.53803794
112kynurenine metabolic process (GO:0070189)2.53598849
113negative regulation of coagulation (GO:0050819)2.52675323
114coronary vasculature morphogenesis (GO:0060977)2.52279075
115mesodermal cell differentiation (GO:0048333)2.51894210
116drug transmembrane transport (GO:0006855)2.51555845
117fatty acid catabolic process (GO:0009062)2.50722428
118response to follicle-stimulating hormone (GO:0032354)2.49989163
119acetyl-CoA metabolic process (GO:0006084)2.49353502
120urate metabolic process (GO:0046415)2.49168187
121regulation of fatty acid oxidation (GO:0046320)2.48618700
122collagen metabolic process (GO:0032963)2.48615544
123epoxygenase P450 pathway (GO:0019373)2.47990400
124high-density lipoprotein particle remodeling (GO:0034375)2.47889444
125plasma lipoprotein particle remodeling (GO:0034369)2.47790530
126protein-lipid complex remodeling (GO:0034368)2.47790530
127macromolecular complex remodeling (GO:0034367)2.47790530
128pathway-restricted SMAD protein phosphorylation (GO:0060389)2.47649213
129gap junction assembly (GO:0016264)2.47573240
130tryptophan metabolic process (GO:0006568)2.47526737
131cell proliferation involved in metanephros development (GO:0072203)2.47314591
132indole-containing compound catabolic process (GO:0042436)2.47311742
133indolalkylamine catabolic process (GO:0046218)2.47311742
134tryptophan catabolic process (GO:0006569)2.47311742
135chemical homeostasis within a tissue (GO:0048875)2.47309731
136cholesterol efflux (GO:0033344)2.47282611
137metanephric mesenchyme development (GO:0072075)2.47142683
138regulation of fatty acid beta-oxidation (GO:0031998)2.46865367
139cellular response to follicle-stimulating hormone stimulus (GO:0071372)2.46774447
140negative regulation of blood vessel endothelial cell migration (GO:0043537)2.46040737
141sprouting angiogenesis (GO:0002040)2.46011251
1422-oxoglutarate metabolic process (GO:0006103)2.45888710
143bile acid biosynthetic process (GO:0006699)2.44972454
144fibrinolysis (GO:0042730)2.44667357
145reverse cholesterol transport (GO:0043691)2.44564270
146cell proliferation involved in kidney development (GO:0072111)2.43422006
147low-density lipoprotein particle remodeling (GO:0034374)2.43369029
148amino-acid betaine transport (GO:0015838)2.42977715
149blood coagulation, intrinsic pathway (GO:0007597)2.42491027
150Notch signaling involved in heart development (GO:0061314)2.42099520
151dermatan sulfate biosynthetic process (GO:0030208)2.40294095
152regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.38375249
153regulation of steroid hormone biosynthetic process (GO:0090030)2.38148638
154mesenchyme morphogenesis (GO:0072132)2.37871669
155peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)2.37282974
156multicellular organismal macromolecule metabolic process (GO:0044259)2.37085135
157collagen catabolic process (GO:0030574)2.36885709
158negative regulation of endothelial cell apoptotic process (GO:2000352)2.35248397
159lipoprotein metabolic process (GO:0042157)2.32955794
160substrate-dependent cell migration (GO:0006929)2.32004370
161extracellular matrix disassembly (GO:0022617)2.31743605
162cell-substrate junction assembly (GO:0007044)2.31738712
163mesenchymal cell development (GO:0014031)2.31133626
164regulation of humoral immune response (GO:0002920)2.30572195
165multicellular organismal metabolic process (GO:0044236)2.29646300
166artery morphogenesis (GO:0048844)2.28470686
167negative regulation of Rho protein signal transduction (GO:0035024)2.28218032
168androgen biosynthetic process (GO:0006702)2.28183599
169very-low-density lipoprotein particle assembly (GO:0034379)2.27524955
170blood vessel morphogenesis (GO:0048514)2.27104472
171negative regulation of wound healing (GO:0061045)2.26631715
172negative regulation of smooth muscle cell migration (GO:0014912)2.25825249
173negative regulation of cardiac muscle cell apoptotic process (GO:0010667)2.24924859

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse5.34000287
2PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.94752673
3RXR_22158963_ChIP-Seq_LIVER_Mouse3.81041155
4TRIM28_21343339_ChIP-Seq_HEK293_Human3.72806714
5LXR_22158963_ChIP-Seq_LIVER_Mouse3.53604706
6PPARA_22158963_ChIP-Seq_LIVER_Mouse3.35770253
7CLOCK_20551151_ChIP-Seq_293T_Human2.98918064
8TP63_17297297_ChIP-ChIP_HaCaT_Human2.78610691
9NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.48780909
10STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.48682702
11EGR1_23403033_ChIP-Seq_LIVER_Mouse2.47035830
12FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.45517249
13RARG_19884340_ChIP-ChIP_MEFs_Mouse2.45092819
14BP1_19119308_ChIP-ChIP_Hs578T_Human2.40563901
15GATA2_21666600_ChIP-Seq_HMVEC_Human2.36985612
16TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.17407505
17* NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.14089014
18EP300_21415370_ChIP-Seq_HL-1_Mouse2.13171584
19TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.12999168
20ESR1_22446102_ChIP-Seq_UTERUS_Mouse2.12265777
21GATA1_22025678_ChIP-Seq_K562_Human2.06913038
22GBX2_23144817_ChIP-Seq_PC3_Human1.96438761
23PIAS1_25552417_ChIP-Seq_VCAP_Human1.89138034
24CDX2_19796622_ChIP-Seq_MESCs_Mouse1.87318391
25IRF8_22096565_ChIP-ChIP_GC-B_Human1.86241423
26* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.80509743
27PPAR_26484153_Chip-Seq_NCI-H1993_Human1.75875337
28CJUN_26792858_Chip-Seq_BT549_Human1.74131780
29ESR1_21235772_ChIP-Seq_MCF-7_Human1.70780892
30* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.67839018
31RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.67019008
32ESR2_21235772_ChIP-Seq_MCF-7_Human1.66113081
33IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.65500094
34FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.64086137
35AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.64025607
36GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.61067938
37TBX20_22080862_ChIP-Seq_HEART_Mouse1.60625730
38TBX20_22328084_ChIP-Seq_HEART_Mouse1.60625730
39SMAD_19615063_ChIP-ChIP_OVARY_Human1.56291725
40CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.55967997
41SALL4_18804426_ChIP-ChIP_XEN_Mouse1.55353325
42STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.54974098
43NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.54056326
44NRF2_20460467_ChIP-Seq_MEFs_Mouse1.54056326
45Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.53143855
46SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.53039627
47FOXO3_23340844_ChIP-Seq_DLD1_Human1.50658586
48BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.48724935
49PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.47937343
50SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.42177385
51WT1_19549856_ChIP-ChIP_CCG9911_Human1.41702094
52* STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.41639148
53PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.41534723
54FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.41254988
55ZNF217_24962896_ChIP-Seq_MCF-7_Human1.37893932
56SOX2_20726797_ChIP-Seq_SW620_Human1.36234890
57SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.33057322
58ARNT_22903824_ChIP-Seq_MCF-7_Human1.32523542
59ESR1_20079471_ChIP-ChIP_T-47D_Human1.31502608
60HIF1A_21447827_ChIP-Seq_MCF-7_Human1.30695582
61FOXA2_19822575_ChIP-Seq_HepG2_Human1.30131413
62CTNNB1_20460455_ChIP-Seq_HCT116_Human1.27625630
63EZH2_18974828_ChIP-Seq_MESCs_Mouse1.27010909
64RNF2_18974828_ChIP-Seq_MESCs_Mouse1.27010909
65SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.26552182
66* SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.26026376
67* ZFP57_27257070_Chip-Seq_ESCs_Mouse1.23963471
68* CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.22843893
69* NR3C1_23031785_ChIP-Seq_PC12_Mouse1.22030738
70SMAD4_21799915_ChIP-Seq_A2780_Human1.21132026
71EED_16625203_ChIP-ChIP_MESCs_Mouse1.18533343
72POU3F2_20337985_ChIP-ChIP_501MEL_Human1.18066547
73SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.16885398
74SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.16885398
75CDX2_20551321_ChIP-Seq_CACO-2_Human1.15787285
76SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.12198694
77SMAD3_21741376_ChIP-Seq_HESCs_Human1.11972287
78* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.11542576
79ZNF263_19887448_ChIP-Seq_K562_Human1.11528310
80WT1_25993318_ChIP-Seq_PODOCYTE_Human1.11335415
81* SOX9_24532713_ChIP-Seq_HFSC_Mouse1.11320141
82ELK3_25401928_ChIP-Seq_HUVEC_Human1.11100382
83* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.10070367
84VDR_24787735_ChIP-Seq_THP-1_Human1.09150030
85RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.08896606
86TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.07904999
87* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.07167841
88EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.07062721
89PCGF2_27294783_Chip-Seq_NPCs_Mouse1.05622025
90PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.05554996
91THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.04386547
92GATA4_25053715_ChIP-Seq_YYC3_Human1.04024472
93FLI1_27457419_Chip-Seq_LIVER_Mouse1.03245284
94JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.02304672
95NR3C1_21868756_ChIP-Seq_MCF10A_Human1.02298292
96BRD4_25478319_ChIP-Seq_HGPS_Human1.01824170
97PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.01823665
98GATA1_19941826_ChIP-Seq_K562_Human1.01545359
99FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.01137529
100SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.00798172
101PCGF2_27294783_Chip-Seq_ESCs_Mouse1.00702358
102* ISL1_27105846_Chip-Seq_CPCs_Mouse0.99919354
103SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.99875213
104JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.99338663
105SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.98686753
106BCAT_22108803_ChIP-Seq_LS180_Human0.98163959
107EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.97312626
108CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.97181155
109HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.97086990
110SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse0.96655362
111RUNX_20019798_ChIP-Seq_JUKART_Human0.95715821
112EZH2_27294783_Chip-Seq_NPCs_Mouse0.94977153
113* SOX2_27498859_Chip-Seq_STOMACH_Mouse0.94713121
114* TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.94482933
115KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.93835227
116MYB_21317192_ChIP-Seq_ERMYB_Mouse0.93582227
117TCF4_18268006_ChIP-ChIP_LS174T_Human0.93483480
118PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.93234190
119SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.92971063
120STAT3_23295773_ChIP-Seq_U87_Human0.92874308
121SUZ12_27294783_Chip-Seq_NPCs_Mouse0.91795269
122TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.91757256
123SMAD3_21741376_ChIP-Seq_EPCs_Human0.91494773
124IRF8_27001747_Chip-Seq_BMDM_Mouse0.91409131
125GATA2_19941826_ChIP-Seq_K562_Human0.91048604
126NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.90305778
127PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.89606977
128NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.87194900
129TP63_23658742_ChIP-Seq_EP156T_Human0.86896121
130TP53_16413492_ChIP-PET_HCT116_Human0.86779841
131AHR_22903824_ChIP-Seq_MCF-7_Human0.85203010
132KDM2B_26808549_Chip-Seq_SUP-B15_Human0.83662913
133CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.83531581
134TP53_18474530_ChIP-ChIP_U2OS_Human0.82222610
135ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.80815592
136AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.76691914
137NFIB_24661679_ChIP-Seq_LUNG_Mouse0.75215403
138SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.74092157
139FOXM1_26456572_ChIP-Seq_MCF-7_Human0.73677290
140HNF4A_19822575_ChIP-Seq_HepG2_Human0.73669774

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010368_abnormal_lymphatic_system4.03790648
2MP0004272_abnormal_basement_membrane3.63999383
3MP0005360_urolithiasis3.57482503
4MP0001879_abnormal_lymphatic_vessel3.21586026
5MP0008438_abnormal_cutaneous_collagen3.11290000
6MP0002139_abnormal_hepatobiliary_system3.02504328
7MP0003724_increased_susceptibility_to2.80119694
8MP0005085_abnormal_gallbladder_physiolo2.66700662
9MP0005167_abnormal_blood-brain_barrier2.53695056
10MP0003705_abnormal_hypodermis_morpholog2.51485111
11MP0005365_abnormal_bile_salt2.48176518
12MP0003252_abnormal_bile_duct2.24594527
13MP0006054_spinal_hemorrhage2.10102486
14MP0004084_abnormal_cardiac_muscle2.04734799
15MP0002138_abnormal_hepatobiliary_system2.02934847
16MP0003279_aneurysm2.02378832
17MP0003828_pulmonary_edema1.98863626
18MP0009780_abnormal_chondrocyte_physiolo1.91126133
19MP0005670_abnormal_white_adipose1.88960805
20MP0010329_abnormal_lipoprotein_level1.86092941
21MP0001958_emphysema1.83502428
22MP0004130_abnormal_muscle_cell1.83151573
23MP0005275_abnormal_skin_tensile1.77983669
24MP0005257_abnormal_intraocular_pressure1.74075360
25MP0003300_gastrointestinal_ulcer1.72768528
26MP0003566_abnormal_cell_adhesion1.72510666
27MP0002108_abnormal_muscle_morphology1.68984153
28MP0003868_abnormal_feces_composition1.65277122
29MP0003191_abnormal_cellular_cholesterol1.64594118
30MP0003195_calcinosis1.59187372
31MP0008875_abnormal_xenobiotic_pharmacok1.57733318
32MP0000767_abnormal_smooth_muscle1.54060836
33MP0005083_abnormal_biliary_tract1.52956904
34MP0004215_abnormal_myocardial_fiber1.48862345
35MP0006138_congestive_heart_failure1.45353558
36MP0003283_abnormal_digestive_organ1.42968966
37MP0002837_dystrophic_cardiac_calcinosis1.40506570
38MP0008775_abnormal_heart_ventricle1.40438409
39MP0005330_cardiomyopathy1.39862164
40MP0005503_abnormal_tendon_morphology1.38911790
41MP0000343_altered_response_to1.38316209
42MP0009384_cardiac_valve_regurgitation1.37591534
43MP0000013_abnormal_adipose_tissue1.37217775
44MP0002933_joint_inflammation1.35169137
45MP0002295_abnormal_pulmonary_circulatio1.34767763
46MP0005084_abnormal_gallbladder_morpholo1.28612695
47MP0004036_abnormal_muscle_relaxation1.28263419
48MP0005666_abnormal_adipose_tissue1.27992321
49MP0005164_abnormal_response_to1.27772561
50MP0005508_abnormal_skeleton_morphology1.23454783
51MP0002896_abnormal_bone_mineralization1.22474075
52MP0000249_abnormal_blood_vessel1.22364927
53* MP0005332_abnormal_amino_acid1.21960123
54MP0005623_abnormal_meninges_morphology1.20962847
55MP0010630_abnormal_cardiac_muscle1.19904250
56MP0001544_abnormal_cardiovascular_syste1.19561717
57MP0005385_cardiovascular_system_phenoty1.19561717
58MP0005165_increased_susceptibility_to1.18049742
59MP0000534_abnormal_ureter_morphology1.17746904
60MP0002166_altered_tumor_susceptibility1.14923189
61MP0002972_abnormal_cardiac_muscle1.14740384
62MP0000462_abnormal_digestive_system1.14465427
63MP0002254_reproductive_system_inflammat1.13813700
64MP0009764_decreased_sensitivity_to1.12561154
65MP0003045_fibrosis1.12433992
66MP0002128_abnormal_blood_circulation1.10723154
67MP0009643_abnormal_urine_homeostasis1.10457191
68MP0000609_abnormal_liver_physiology1.09755382
69MP0005319_abnormal_enzyme/_coenzyme1.09708846
70MP0002118_abnormal_lipid_homeostasis1.07717228
71MP0004883_abnormal_blood_vessel1.06985312
72MP0005595_abnormal_vascular_smooth1.06647087
73MP0002909_abnormal_adrenal_gland1.06108369
74MP0003091_abnormal_cell_migration1.03653327
75MP0005620_abnormal_muscle_contractility1.03489874
76MP0001756_abnormal_urination1.02567781
77MP0003303_peritoneal_inflammation1.02050239
78MP0004484_altered_response_of1.01447456
79MP0001666_abnormal_nutrient_absorption1.01118844
80MP0005375_adipose_tissue_phenotype0.98431697
81MP0000751_myopathy0.96421898
82MP0001661_extended_life_span0.94702784
83MP0000230_abnormal_systemic_arterial0.94661947
84MP0000639_abnormal_adrenal_gland0.94561671
85MP0002060_abnormal_skin_morphology0.94097244
86MP0001614_abnormal_blood_vessel0.92451776
87MP0009250_abnormal_appendicular_skeleto0.91705485
88MP0004185_abnormal_adipocyte_glucose0.91450824
89MP0004019_abnormal_vitamin_homeostasis0.90965636
90MP0010352_gastrointestinal_tract_polyps0.90618888
91MP0000538_abnormal_urinary_bladder0.90544993
92MP0009278_abnormal_bone_marrow0.90001432
93MP0003950_abnormal_plasma_membrane0.89835225
94MP0003941_abnormal_skin_development0.89362163
95MP0010386_abnormal_urinary_bladder0.89285461
96MP0004087_abnormal_muscle_fiber0.89187938
97MP0000749_muscle_degeneration0.87314261
98MP0003385_abnormal_body_wall0.86065081
99MP0002971_abnormal_brown_adipose0.85393481
100MP0000003_abnormal_adipose_tissue0.85043208
101MP0005023_abnormal_wound_healing0.84659735
102MP0000163_abnormal_cartilage_morphology0.83788819
103MP0001542_abnormal_bone_strength0.83198705
104MP0009697_abnormal_copulation0.82112385
105MP0001533_abnormal_skeleton_physiology0.82036660
106MP0009763_increased_sensitivity_to0.81735203
107MP0002006_tumorigenesis0.81022966
108MP0002876_abnormal_thyroid_physiology0.79836897
109MP0003942_abnormal_urinary_system0.79506333
110MP0003806_abnormal_nucleotide_metabolis0.79457511
111MP0009053_abnormal_anal_canal0.79208060
112MP0004147_increased_porphyrin_level0.79135101
113MP0002127_abnormal_cardiovascular_syste0.78862310
114MP0002925_abnormal_cardiovascular_devel0.78712339
115MP0001299_abnormal_eye_distance/0.78409016
116MP0008004_abnormal_stomach_pH0.78053355
117MP0002332_abnormal_exercise_endurance0.77745045
118MP0002115_abnormal_skeleton_extremities0.77332968
119MP0010234_abnormal_vibrissa_follicle0.76421742
120MP0002136_abnormal_kidney_physiology0.75093426
121MP0002998_abnormal_bone_remodeling0.74966201
122MP0002168_other_aberrant_phenotype0.74418823
123MP0001270_distended_abdomen0.73713461
124MP0009840_abnormal_foam_cell0.73498072
125MP0001915_intracranial_hemorrhage0.72646221
126MP0004134_abnormal_chest_morphology0.72590652
127MP0002269_muscular_atrophy0.72259362
128MP0000598_abnormal_liver_morphology0.71849033
129MP0005187_abnormal_penis_morphology0.70041973
130MP0005369_muscle_phenotype0.69896141
131MP0003448_altered_tumor_morphology0.69374247
132MP0002133_abnormal_respiratory_system0.68254745
133MP0005388_respiratory_system_phenotype0.68254745
134MP0005584_abnormal_enzyme/coenzyme_acti0.67810905
135MP0005197_abnormal_uvea_morphology0.66984976
136MP0005390_skeleton_phenotype0.66001203
137MP0004085_abnormal_heartbeat0.65884972

Predicted human phenotypes

RankGene SetZ-score
1Deep venous thrombosis (HP:0002625)4.48909409
2Soft skin (HP:0000977)4.05740469
3Arterial tortuosity (HP:0005116)3.81929842
4Esophageal varix (HP:0002040)3.78703767
5Aortic aneurysm (HP:0004942)3.77223061
6Aortic dissection (HP:0002647)3.51735319
7Polycythemia (HP:0001901)3.49117076
8Hypoglycemic coma (HP:0001325)3.45973720
9Cerebral aneurysm (HP:0004944)3.39771448
10Xanthomatosis (HP:0000991)3.36842477
11Hematochezia (HP:0002573)3.27226330
12Broad metatarsal (HP:0001783)3.22286881
13Intrahepatic cholestasis (HP:0001406)3.16198041
14Protrusio acetabuli (HP:0003179)3.12440853
15Glomerulonephritis (HP:0000099)3.11730426
16Hypoalphalipoproteinemia (HP:0003233)3.10488736
17Premature rupture of membranes (HP:0001788)3.03963639
18Joint hemorrhage (HP:0005261)2.99627106
19Bladder diverticulum (HP:0000015)2.93394117
20Lymphangioma (HP:0100764)2.89779960
21Myocardial infarction (HP:0001658)2.89587964
22Increased connective tissue (HP:0009025)2.86644837
23Follicular hyperkeratosis (HP:0007502)2.84016421
24Wormian bones (HP:0002645)2.82825627
25Right ventricular cardiomyopathy (HP:0011663)2.82806767
26Fragile skin (HP:0001030)2.81660732
27Complement deficiency (HP:0004431)2.80863324
28Hemorrhage of the eye (HP:0011885)2.79243991
29Abnormality of glutamine family amino acid metabolism (HP:0010902)2.77529122
30Prolonged partial thromboplastin time (HP:0003645)2.76417257
31Spontaneous hematomas (HP:0007420)2.73291314
32Blue sclerae (HP:0000592)2.72953517
33Abnormality of the common coagulation pathway (HP:0010990)2.70227392
34Hyperlipoproteinemia (HP:0010980)2.64941442
35Abnormality of monocarboxylic acid metabolism (HP:0010996)2.64432957
36Muscle fiber splitting (HP:0003555)2.63573504
37Aneurysm (HP:0002617)2.62643673
38Abnormality of the intrinsic pathway (HP:0010989)2.58329305
39Ventricular tachycardia (HP:0004756)2.56681133
40Cardiovascular calcification (HP:0011915)2.55113292
41Nonimmune hydrops fetalis (HP:0001790)2.54797152
42Wide anterior fontanel (HP:0000260)2.53343073
43Hypolipoproteinemia (HP:0010981)2.52632111
44Hyperglycinuria (HP:0003108)2.52501391
45Abnormality of dentin (HP:0010299)2.50624491
46Hyperammonemia (HP:0001987)2.50542185
47Abnormal delivery (HP:0001787)2.50212261
48Peritonitis (HP:0002586)2.49450025
49Sudden death (HP:0001699)2.46357807
50Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.45637864
51Ketosis (HP:0001946)2.42177328
52Striae distensae (HP:0001065)2.40376626
53Facial diplegia (HP:0001349)2.37550417
54Mitral valve prolapse (HP:0001634)2.37290419
55Neonatal short-limb short stature (HP:0008921)2.36539781
56Hyporeflexia of lower limbs (HP:0002600)2.35016358
57Overgrowth (HP:0001548)2.32766807
58Abnormality of fatty-acid metabolism (HP:0004359)2.32511207
59Abnormality of aromatic amino acid family metabolism (HP:0004338)2.30965384
60Vertebral arch anomaly (HP:0008438)2.30852009
61Lipoatrophy (HP:0100578)2.29866727
62Short hallux (HP:0010109)2.28606062
63Abnormality of the ischium (HP:0003174)2.28020475
64Visceral angiomatosis (HP:0100761)2.27035957
65Vascular calcification (HP:0004934)2.26664192
66Hypoplastic ischia (HP:0003175)2.25228073
67Ankle contracture (HP:0006466)2.24013506
68Asymmetry of the thorax (HP:0001555)2.23092155
69Spondylolisthesis (HP:0003302)2.19840063
70Ketoacidosis (HP:0001993)2.18938522
71Hydroxyprolinuria (HP:0003080)2.18384234
72Abnormality of proline metabolism (HP:0010907)2.18384234
73Stroke (HP:0001297)2.18138122
74Epidermoid cyst (HP:0200040)2.18104539
75Increased corneal curvature (HP:0100692)2.14804007
76Keratoconus (HP:0000563)2.14804007
77Hepatocellular carcinoma (HP:0001402)2.14159526
78Cervical subluxation (HP:0003308)2.12603484
79Ovoid vertebral bodies (HP:0003300)2.12481730
80Bone cyst (HP:0012062)2.11928028
81Hemangiomatosis (HP:0007461)2.10482732
82Aplasia/Hypoplasia of the hallux (HP:0008362)2.09858346
83Abnormality of serine family amino acid metabolism (HP:0010894)2.09498995
84Abnormality of glycine metabolism (HP:0010895)2.09498995
85Hypercholesterolemia (HP:0003124)2.08882127
86Osteolytic defects of the hand bones (HP:0009699)2.08410067
87Osteolytic defects of the phalanges of the hand (HP:0009771)2.08410067
88Hyperextensible skin (HP:0000974)2.06820945
89Chondrocalcinosis (HP:0000934)2.06689541
90Nephritis (HP:0000123)2.06640835
91Conjugated hyperbilirubinemia (HP:0002908)2.06551996
92Abnormality of complement system (HP:0005339)2.05319554
93Limited hip movement (HP:0008800)2.04614264
94Abnormality of carpal bone ossification (HP:0006257)2.02666427
95Tetraparesis (HP:0002273)2.02402183
96Skin nodule (HP:0200036)2.02401027
97Ectopia lentis (HP:0001083)2.02354761
98Hypoplasia of the iris (HP:0007676)2.02146124
99Hypobetalipoproteinemia (HP:0003563)2.01714248
100Osteoarthritis (HP:0002758)2.01249262
101Abnormality of the acetabulum (HP:0003170)1.99742464
102Vascular tortuosity (HP:0004948)1.99126228
103Abnormal cartilage morphology (HP:0002763)1.99086813
104Conjunctival telangiectasia (HP:0000524)1.98052783
105Shallow orbits (HP:0000586)1.97506354
106Cerebral hemorrhage (HP:0001342)1.97272784
107Abnormality of the vasculature of the conjunctiva (HP:0008054)1.95191496
108Recurrent gram-negative bacterial infections (HP:0005420)1.94788013
109Cupped ribs (HP:0000887)1.92794340
110Delayed closure of the anterior fontanelle (HP:0001476)1.92641395
111Fat malabsorption (HP:0002630)1.92277457
112Abnormality of purine metabolism (HP:0004352)1.91907158
113Hypertriglyceridemia (HP:0002155)1.91855028
114Dilatation of the ascending aorta (HP:0005111)1.91779735
115Hypoglycemic seizures (HP:0002173)1.91609113
116Joint laxity (HP:0001388)1.91286593
117Spinal rigidity (HP:0003306)1.91217396
118Acanthosis nigricans (HP:0000956)1.91049002
119Flared iliac wings (HP:0002869)1.90695866
120Atrophic scars (HP:0001075)1.90404063
121Mitral stenosis (HP:0001718)1.89428330
122Venous abnormality (HP:0002624)1.89399111
123Increased mean platelet volume (HP:0011877)1.89063259
124Nausea (HP:0002018)1.88549926
125Abnormality of Sharpey fibers (HP:0100685)1.88323889
126Knee flexion contracture (HP:0006380)1.88308010
127Bowel diverticulosis (HP:0005222)1.87522202
128Neoplasm of the heart (HP:0100544)1.87363362
129Aortic regurgitation (HP:0001659)1.87035291
130Facial shape deformation (HP:0011334)1.86936330
131Potter facies (HP:0002009)1.86936330
132Focal segmental glomerulosclerosis (HP:0000097)1.86441288
133Portal hypertension (HP:0001409)1.85764942
134Genu recurvatum (HP:0002816)1.84958605
135Increased variability in muscle fiber diameter (HP:0003557)1.84113824
136Type 1 muscle fiber predominance (HP:0003803)1.83703530
137Thrombophlebitis (HP:0004418)1.81413071
138Systemic lupus erythematosus (HP:0002725)1.80727270
139Pulmonary artery stenosis (HP:0004415)1.80258649
140Slender build (HP:0001533)1.78268307
141Abnormal ossification of hand bones (HP:0005921)1.77230768
142Venous insufficiency (HP:0005293)1.76769937
143Round ear (HP:0100830)1.75731625
144Metaphyseal dysplasia (HP:0100255)1.75580346
145Malnutrition (HP:0004395)1.75207381
146Gingival overgrowth (HP:0000212)1.75116398
147Menorrhagia (HP:0000132)1.72732930
148Vertebral compression fractures (HP:0002953)1.68897974

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TIE16.30870388
2KDR4.90898945
3MYLK2.97769219
4TGFBR22.79623073
5TTN2.67332505
6NTRK12.38498806
7ERN12.18061311
8FRK2.14354724
9RIPK12.12017853
10TRIB32.08705805
11SIK12.06468951
12EPHB21.93087002
13INSRR1.83176005
14PDK21.82122797
15FGFR41.79327318
16PDGFRA1.76765221
17DMPK1.72957834
18BCKDK1.71425663
19NEK91.61476544
20PTK2B1.52049118
21PKN21.51395130
22LATS11.50857897
23NUAK11.43214592
24CDC42BPA1.42608811
25PTK61.41304471
26FGFR31.31887374
27TGFBR11.30554654
28JAK11.29036688
29MAP3K31.26822962
30CAMK1D1.20437914
31FGFR21.20344208
32PDK31.16656553
33PDK41.16656553
34LMTK21.16543275
35EPHB11.13563481
36LATS21.11219845
37MAP3K141.06218190
38MAP2K31.02225514
39PRKG21.01469284
40FER1.00467473
41TAF10.99481916
42EPHA30.99187510
43PRKAA20.98349365
44STK380.93528663
45MST1R0.93105285
46LRRK20.92119782
47MAP3K20.91127574
48PAK20.90869092
49OBSCN0.90411735
50ADRBK10.90211039
51GRK70.89928318
52TBK10.89251528
53MELK0.88652184
54PIK3CA0.88211424
55CAMK1G0.88160208
56DDR20.88111549
57TYK20.85917315
58MET0.85361483
59PTK20.85211550
60MAPKAPK30.84732877
61PDGFRB0.83123062
62CSK0.81910513
63TRPM70.81114046
64STK30.80211206
65ZAP700.79177744
66MAPK120.79138393
67PIK3CG0.75522791
68PRKD10.74802388
69GSK3A0.74242962
70OXSR10.73299726
71WNK40.72663956
72ITK0.72402551
73JAK30.69617116
74ROCK10.66559551
75JAK20.64895094
76PAK40.64653847
77STK100.63463378
78BMPR1B0.61319360
79LIMK10.60778161
80KIT0.60207728
81MARK30.58281392
82PRKCE0.56070829
83AKT30.55558929
84PDPK10.55411067
85IGF1R0.55047592
86GRK10.54007803
87MAP2K10.53798191
88PRKG10.53772058
89FLT30.53751630
90PAK30.53656930
91PRKCH0.53425038
92ACVR1B0.52741326
93WNK10.52340961
94TEC0.52260136
95RET0.52101086
96ABL20.52062166
97MAP3K100.50259919
98CAMKK20.50064022
99ADRBK20.49178481
100NTRK30.48014305
101BMX0.47625558
102MAPK70.46690408
103STK38L0.46425820
104PRKD20.45927469
105INSR0.44752161
106MAP3K70.43746776
107EGFR0.43609087
108STK240.43575974
109CDK60.43045533
110PRKAA10.42959137
111MAPK110.42767249
112MTOR0.42692782
113EEF2K0.42538875
114TAOK30.41279296
115MAP2K20.40916190
116ERBB40.39361488
117STK390.39169824
118ZAK0.38704460
119ICK0.38112911
120ABL10.37842977
121NLK0.36930548
122PHKG10.36264392
123PHKG20.36264392
124ROCK20.35228326
125FGFR10.35056335
126TESK10.34137518
127SGK20.33805579
128PINK10.32907095
129SRC0.32349469
130PRKACG0.31964357
131MAP4K20.30571126

Predicted pathways (KEGG)

RankGene SetZ-score
1Nitrogen metabolism_Homo sapiens_hsa009103.06699639
2Fatty acid degradation_Homo sapiens_hsa000712.83409798
3Primary bile acid biosynthesis_Homo sapiens_hsa001202.73574950
4Complement and coagulation cascades_Homo sapiens_hsa046102.64335178
5Propanoate metabolism_Homo sapiens_hsa006402.53197709
6PPAR signaling pathway_Homo sapiens_hsa033202.47641030
7Arginine biosynthesis_Homo sapiens_hsa002202.44493083
8Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.30627633
9Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.25524849
10Tryptophan metabolism_Homo sapiens_hsa003802.19808367
11Fatty acid metabolism_Homo sapiens_hsa012122.10127505
12Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.00985232
13Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.81876403
14* ECM-receptor interaction_Homo sapiens_hsa045121.76837618
15Staphylococcus aureus infection_Homo sapiens_hsa051501.74062234
16Bile secretion_Homo sapiens_hsa049761.62387682
17Pentose and glucuronate interconversions_Homo sapiens_hsa000401.59883668
18Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.52877130
19Caffeine metabolism_Homo sapiens_hsa002321.52205772
202-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.51846569
21Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.46469365
22* Focal adhesion_Homo sapiens_hsa045101.41304202
23Peroxisome_Homo sapiens_hsa041461.40563278
24beta-Alanine metabolism_Homo sapiens_hsa004101.33203840
25Butanoate metabolism_Homo sapiens_hsa006501.32715492
26Prion diseases_Homo sapiens_hsa050201.31140577
27Glycosaminoglycan degradation_Homo sapiens_hsa005311.30666854
28Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.29733990
29Starch and sucrose metabolism_Homo sapiens_hsa005001.27589332
30Adherens junction_Homo sapiens_hsa045201.22533458
31Fat digestion and absorption_Homo sapiens_hsa049751.21137455
32ABC transporters_Homo sapiens_hsa020101.20611075
33Malaria_Homo sapiens_hsa051441.20518977
34Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.20237799
35Vitamin digestion and absorption_Homo sapiens_hsa049771.18575250
36Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.18526322
37Protein digestion and absorption_Homo sapiens_hsa049741.14886077
38Renin secretion_Homo sapiens_hsa049241.14072156
39Pyruvate metabolism_Homo sapiens_hsa006201.12117318
40Amoebiasis_Homo sapiens_hsa051461.11301940
41Leukocyte transendothelial migration_Homo sapiens_hsa046701.07854192
42Carbon metabolism_Homo sapiens_hsa012001.04302509
43Insulin resistance_Homo sapiens_hsa049311.03519973
44Lysine degradation_Homo sapiens_hsa003101.01475250
45Histidine metabolism_Homo sapiens_hsa003401.00974882
46Adipocytokine signaling pathway_Homo sapiens_hsa049200.99218163
47AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.97100549
48Chemical carcinogenesis_Homo sapiens_hsa052040.95800428
49Fatty acid biosynthesis_Homo sapiens_hsa000610.93243116
50Phenylalanine metabolism_Homo sapiens_hsa003600.91879964
51Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.90700014
52* Dilated cardiomyopathy_Homo sapiens_hsa054140.90484904
53Sulfur metabolism_Homo sapiens_hsa009200.90106759
54Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.90019051
55Steroid hormone biosynthesis_Homo sapiens_hsa001400.88700456
56Small cell lung cancer_Homo sapiens_hsa052220.87664524
57* Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.86574694
58Mineral absorption_Homo sapiens_hsa049780.85520119
59Aldosterone synthesis and secretion_Homo sapiens_hsa049250.84863133
60Glycerolipid metabolism_Homo sapiens_hsa005610.83865317
61Selenocompound metabolism_Homo sapiens_hsa004500.81090584
62Viral myocarditis_Homo sapiens_hsa054160.80828302
63Cyanoamino acid metabolism_Homo sapiens_hsa004600.77257994
64Thyroid hormone synthesis_Homo sapiens_hsa049180.74356430
65Retinol metabolism_Homo sapiens_hsa008300.74260875
66Maturity onset diabetes of the young_Homo sapiens_hsa049500.74187570
67Tyrosine metabolism_Homo sapiens_hsa003500.69257466
68Toxoplasmosis_Homo sapiens_hsa051450.66885523
69Arginine and proline metabolism_Homo sapiens_hsa003300.66740596
70* Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.66603377
71Proteoglycans in cancer_Homo sapiens_hsa052050.66531077
72Linoleic acid metabolism_Homo sapiens_hsa005910.64806747
73Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.63846241
74Fatty acid elongation_Homo sapiens_hsa000620.63720538
75Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.60903931
76Platelet activation_Homo sapiens_hsa046110.59343974
77Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.58722900
78African trypanosomiasis_Homo sapiens_hsa051430.55755574
79Dorso-ventral axis formation_Homo sapiens_hsa043200.54564416
80* PI3K-Akt signaling pathway_Homo sapiens_hsa041510.52687278
81Other glycan degradation_Homo sapiens_hsa005110.52310646
82Renin-angiotensin system_Homo sapiens_hsa046140.51990445
83Circadian rhythm_Homo sapiens_hsa047100.51658918
84Leishmaniasis_Homo sapiens_hsa051400.50334954
85TNF signaling pathway_Homo sapiens_hsa046680.50089240
86AMPK signaling pathway_Homo sapiens_hsa041520.49813358
87Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.49519808
88Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.47633293
89Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.46855337
90Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.46774295
91Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.46299900
92Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.45401879
93Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.45106560
94Rap1 signaling pathway_Homo sapiens_hsa040150.43187180
95Pathways in cancer_Homo sapiens_hsa052000.42760353
96Vascular smooth muscle contraction_Homo sapiens_hsa042700.42694043
97Phospholipase D signaling pathway_Homo sapiens_hsa040720.42461916
98Gap junction_Homo sapiens_hsa045400.41872382
99Sphingolipid metabolism_Homo sapiens_hsa006000.40729385
100Osteoclast differentiation_Homo sapiens_hsa043800.40375187
101Arachidonic acid metabolism_Homo sapiens_hsa005900.39764331
102Drug metabolism - other enzymes_Homo sapiens_hsa009830.39186894
103Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.39104532
104Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.37717113
105Estrogen signaling pathway_Homo sapiens_hsa049150.37534881
106TGF-beta signaling pathway_Homo sapiens_hsa043500.37362852
107MicroRNAs in cancer_Homo sapiens_hsa052060.37008809
108HIF-1 signaling pathway_Homo sapiens_hsa040660.36245443
109Biosynthesis of amino acids_Homo sapiens_hsa012300.34971101
110Salivary secretion_Homo sapiens_hsa049700.34705671
111Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.34658542
112Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.34630452
113Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.34152170
114Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.33895150
115Ovarian steroidogenesis_Homo sapiens_hsa049130.33850174
116Calcium signaling pathway_Homo sapiens_hsa040200.33694705
117alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.33619004
118Legionellosis_Homo sapiens_hsa051340.33105318
119Melanoma_Homo sapiens_hsa052180.32052571
120Pertussis_Homo sapiens_hsa051330.31541495
121Hippo signaling pathway_Homo sapiens_hsa043900.31064831
122Tight junction_Homo sapiens_hsa045300.30708875
123Glucagon signaling pathway_Homo sapiens_hsa049220.30396009
124* Regulation of actin cytoskeleton_Homo sapiens_hsa048100.29242819
125Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.27362870
126Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.26874257
127cGMP-PKG signaling pathway_Homo sapiens_hsa040220.26862950
128Salmonella infection_Homo sapiens_hsa051320.25839139
129Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.24933117
130Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.24911452

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