ITGA10

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Integrins are integral transmembrane glycoproteins composed of noncovalently linked alpha and beta chains. They participate in cell adhesion as well as cell-surface mediated signalling. This gene encodes an integrin alpha chain and is expressed at high levels in chondrocytes, where it is transcriptionally regulated by AP-2epsilon and Ets-1. The protein encoded by this gene binds to collagen. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1keratan sulfate catabolic process (GO:0042340)8.95403451
2cartilage development involved in endochondral bone morphogenesis (GO:0060351)8.12997375
3chondrocyte development (GO:0002063)7.36292623
4collagen fibril organization (GO:0030199)7.28778122
5cell aggregation (GO:0098743)6.67623481
6cartilage condensation (GO:0001502)6.67623481
7collagen catabolic process (GO:0030574)5.45975866
8collagen metabolic process (GO:0032963)5.30485973
9regulation of extracellular matrix disassembly (GO:0010715)5.28064575
10positive regulation of extracellular matrix organization (GO:1903055)5.12467665
11multicellular organismal catabolic process (GO:0044243)5.02999156
12protein heterotrimerization (GO:0070208)5.02367870
13multicellular organismal macromolecule metabolic process (GO:0044259)5.02215027
14mesenchymal-epithelial cell signaling (GO:0060638)4.92093431
15bone trabecula formation (GO:0060346)4.77436424
16multicellular organismal metabolic process (GO:0044236)4.76632924
17endochondral ossification (GO:0001958)4.71136516
18replacement ossification (GO:0036075)4.71136516
19keratan sulfate biosynthetic process (GO:0018146)4.43251522
20notochord development (GO:0030903)4.38881280
21chondrocyte differentiation (GO:0002062)4.21891130
22cartilage development (GO:0051216)4.20812794
23extracellular matrix disassembly (GO:0022617)4.17838944
24peptidyl-proline hydroxylation (GO:0019511)4.11745723
25skin morphogenesis (GO:0043589)3.97629130
26chondroitin sulfate biosynthetic process (GO:0030206)3.95889031
27lymphangiogenesis (GO:0001946)3.94959690
28regulation of cytokine production involved in inflammatory response (GO:1900015)3.93042701
29radial glial cell differentiation (GO:0060019)3.92739029
30positive regulation of chondrocyte differentiation (GO:0032332)3.88999894
31negative regulation of vascular endothelial growth factor receptor signaling pathway (GO:0030948)3.88197486
32endothelial cell morphogenesis (GO:0001886)3.85516937
33endodermal cell differentiation (GO:0035987)3.84858739
34limb bud formation (GO:0060174)3.79136919
35negative regulation of Rho protein signal transduction (GO:0035024)3.78356679
36regulation of extracellular matrix organization (GO:1903053)3.75382432
37glomerular basement membrane development (GO:0032836)3.75238931
38regulation of branching involved in salivary gland morphogenesis (GO:0060693)3.74782177
39regulation of lipoprotein metabolic process (GO:0050746)3.73977865
40chondrocyte proliferation (GO:0035988)3.73792203
41proteoglycan metabolic process (GO:0006029)3.72831666
42positive regulation of astrocyte differentiation (GO:0048711)3.72466384
43keratan sulfate metabolic process (GO:0042339)3.71753210
44skeletal system development (GO:0001501)3.68854772
45response to gravity (GO:0009629)3.68142674
46dermatan sulfate metabolic process (GO:0030205)3.60973508
47embryonic skeletal joint morphogenesis (GO:0060272)3.54565229
48ossification (GO:0001503)3.54172003
49negative regulation of focal adhesion assembly (GO:0051895)3.47732410
50negative regulation of cell junction assembly (GO:1901889)3.47732410
51negative regulation of adherens junction organization (GO:1903392)3.47732410
52positive regulation of cartilage development (GO:0061036)3.45702368
53regulation of secondary heart field cardioblast proliferation (GO:0003266)3.44472173
54regulation of cardioblast proliferation (GO:0003264)3.44472173
55cellular response to cadmium ion (GO:0071276)3.38802252
56retina vasculature morphogenesis in camera-type eye (GO:0061299)3.37788064
57biomineral tissue development (GO:0031214)3.35002777
58regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)3.29127238
59protein hydroxylation (GO:0018126)3.28434929
60* extracellular matrix organization (GO:0030198)3.25294605
61regulation of transcription from RNA polymerase II promoter in response to oxidative stress (GO:00433.25100255
62* extracellular structure organization (GO:0043062)3.23910868
63COPI coating of Golgi vesicle (GO:0048205)3.23830696
64Golgi transport vesicle coating (GO:0048200)3.23830696
65cellular glucuronidation (GO:0052695)3.22018727
66inner ear receptor stereocilium organization (GO:0060122)3.18677172
67sequestering of extracellular ligand from receptor (GO:0035581)3.18245233
68negative regulation of gluconeogenesis (GO:0045721)3.17314309
69regulation of integrin-mediated signaling pathway (GO:2001044)3.16661117
70sulfur compound catabolic process (GO:0044273)3.15912656
71regulation of plasminogen activation (GO:0010755)3.14500302
72vascular endothelial growth factor signaling pathway (GO:0038084)3.13381413
73insulin-like growth factor receptor signaling pathway (GO:0048009)3.08545272
74glycosaminoglycan biosynthetic process (GO:0006024)3.08408678
75aminoglycan biosynthetic process (GO:0006023)3.06647980
76regulation of heart morphogenesis (GO:2000826)3.06470787
77cellular zinc ion homeostasis (GO:0006882)3.05430907
78negative regulation of axon extension involved in axon guidance (GO:0048843)3.04399194
79glycosaminoglycan catabolic process (GO:0006027)3.04004059
80bone mineralization (GO:0030282)3.03078701
81fucose catabolic process (GO:0019317)3.02534878
82L-fucose metabolic process (GO:0042354)3.02534878
83L-fucose catabolic process (GO:0042355)3.02534878
84regulation of cell proliferation involved in heart morphogenesis (GO:2000136)3.01243262
85regulation of chondrocyte differentiation (GO:0032330)2.99457550
86nucleotide-sugar biosynthetic process (GO:0009226)2.96519611
87substrate-dependent cell migration (GO:0006929)2.94674150
88cellular response to vitamin D (GO:0071305)2.92154112
89cellular response to nitric oxide (GO:0071732)2.91916655
90detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.91349854
91regulation of cartilage development (GO:0061035)2.91087675
92positive regulation of hormone biosynthetic process (GO:0046886)2.86693752
93regulation of bone mineralization (GO:0030500)2.86565368
94positive regulation of fatty acid beta-oxidation (GO:0032000)2.86539593
95aminoglycan catabolic process (GO:0006026)2.84829197
96face morphogenesis (GO:0060325)2.83938607
97smooth muscle tissue development (GO:0048745)2.83355031
98multicellular organism reproduction (GO:0032504)2.82457247
99behavioral response to nicotine (GO:0035095)2.82307319
100neuron projection extension involved in neuron projection guidance (GO:1902284)2.80412712
101axon extension involved in axon guidance (GO:0048846)2.80412712
102tooth mineralization (GO:0034505)2.79622159
103embryonic cranial skeleton morphogenesis (GO:0048701)2.76544686
104negative regulation of heart growth (GO:0061117)2.76323422
105negative regulation of cardiac muscle tissue growth (GO:0055022)2.76323422
106positive regulation of mesenchymal cell proliferation (GO:0002053)2.76192404
107muscle cell fate commitment (GO:0042693)2.75135032
108type B pancreatic cell proliferation (GO:0044342)2.72808907
109regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.72752623
110negative regulation of platelet-derived growth factor receptor signaling pathway (GO:0010642)2.72655656
111regulation of biomineral tissue development (GO:0070167)2.72323266
112negative regulation of nitric-oxide synthase activity (GO:0051001)2.71075978
113lung vasculature development (GO:0060426)2.68540909
114embryonic retina morphogenesis in camera-type eye (GO:0060059)2.68378231
115lipopolysaccharide biosynthetic process (GO:0009103)2.66943021
116negative regulation of protein autophosphorylation (GO:0031953)2.66534704
117positive regulation of defense response to virus by host (GO:0002230)2.66486502
118substrate adhesion-dependent cell spreading (GO:0034446)2.65263798
119blood vessel maturation (GO:0001955)2.64830423
120wound healing, spreading of epidermal cells (GO:0035313)2.64591394
121positive regulation of osteoblast proliferation (GO:0033690)2.64247493
122negative regulation of hormone biosynthetic process (GO:0032353)2.64095812
123negative regulation of hormone metabolic process (GO:0032351)2.64095812
124UDP-N-acetylglucosamine metabolic process (GO:0006047)2.62585986
125protein retention in ER lumen (GO:0006621)2.62413960
126response to pheromone (GO:0019236)2.61487342
127bone development (GO:0060348)2.60599407
128dermatan sulfate biosynthetic process (GO:0030208)2.60262089
129zinc ion homeostasis (GO:0055069)2.60237020
130regulation of platelet-derived growth factor receptor signaling pathway (GO:0010640)2.59798912
131branch elongation of an epithelium (GO:0060602)2.59704425
132craniofacial suture morphogenesis (GO:0097094)2.59079662
133osteoblast differentiation (GO:0001649)2.58742314
134organ induction (GO:0001759)2.58624775
135endothelial cell proliferation (GO:0001935)2.58499406
136negative regulation of cartilage development (GO:0061037)2.57724137
137inositol phosphate-mediated signaling (GO:0048016)2.57678524
138glucuronate metabolic process (GO:0019585)2.57090908
139uronic acid metabolic process (GO:0006063)2.57090908
140glomerular visceral epithelial cell development (GO:0072015)2.55987948
141negative regulation of axon guidance (GO:1902668)2.55655744
142negative regulation of chondrocyte differentiation (GO:0032331)2.54338746
143proteoglycan biosynthetic process (GO:0030166)2.53116854
144chondroitin sulfate metabolic process (GO:0030204)2.52645246
145glial cell migration (GO:0008347)2.52293752
146muscle cell migration (GO:0014812)2.51759771
147regulation of endothelial cell differentiation (GO:0045601)2.51504440
148metanephric mesenchyme development (GO:0072075)2.51368322
149phasic smooth muscle contraction (GO:0014821)2.49704373
150positive regulation of glycogen biosynthetic process (GO:0045725)2.48452755
151detection of light stimulus involved in sensory perception (GO:0050962)2.47157445
152detection of light stimulus involved in visual perception (GO:0050908)2.47157445
153endothelium development (GO:0003158)2.47104039
154positive regulation of stem cell differentiation (GO:2000738)2.47080835
155regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:00033392.44585233
156peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)2.44311641
157chondroitin sulfate catabolic process (GO:0030207)2.44207088
158negative regulation of synaptic transmission, GABAergic (GO:0032229)2.43415656
159negative regulation of telomere maintenance (GO:0032205)2.41870761
160cellular response to zinc ion (GO:0071294)2.41423972
161cell migration involved in heart development (GO:0060973)2.41155215
162negative regulation of platelet activation (GO:0010544)2.40740681
163regulation of gonadotropin secretion (GO:0032276)2.38245598
164kidney mesenchyme development (GO:0072074)2.37563604
165regulation of hippo signaling (GO:0035330)2.33015520
166detection of mechanical stimulus involved in sensory perception (GO:0050974)2.32595500
167tonic smooth muscle contraction (GO:0014820)2.30896667
168basement membrane organization (GO:0071711)2.29920851
169positive regulation of phosphoprotein phosphatase activity (GO:0032516)2.29233889
170glycosphingolipid biosynthetic process (GO:0006688)2.29126392
171arginine catabolic process (GO:0006527)2.28945874
172extracellular fibril organization (GO:0043206)2.28301439
173organ formation (GO:0048645)2.28231500
174sprouting angiogenesis (GO:0002040)2.27410541
1753-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)2.27015526
176purine ribonucleoside bisphosphate metabolic process (GO:0034035)2.27015526
177piRNA metabolic process (GO:0034587)2.26226830
178auditory receptor cell stereocilium organization (GO:0060088)2.24382653
179artery smooth muscle contraction (GO:0014824)2.24128568

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TRIM28_21343339_ChIP-Seq_HEK293_Human4.70523781
2TP63_17297297_ChIP-ChIP_HaCaT_Human3.94326936
3ZNF274_21170338_ChIP-Seq_K562_Hela2.75489162
4BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.60163470
5SMAD_19615063_ChIP-ChIP_OVARY_Human2.54685677
6AR_21572438_ChIP-Seq_LNCaP_Human2.44686241
7EZH2_22144423_ChIP-Seq_EOC_Human2.42210458
8PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.32372926
9ESR1_22446102_ChIP-Seq_UTERUS_Mouse2.29656212
10RARG_19884340_ChIP-ChIP_MEFs_Mouse2.25926818
11VDR_22108803_ChIP-Seq_LS180_Human2.22185855
12ZFP57_27257070_Chip-Seq_ESCs_Mouse2.18603619
13GATA2_21666600_ChIP-Seq_HMVEC_Human2.15796797
14EED_16625203_ChIP-ChIP_MESCs_Mouse1.96297300
15PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.94804222
16SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.90741700
17SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.90412416
18SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.89077876
19ESR1_21235772_ChIP-Seq_MCF-7_Human1.87684748
20DROSHA_22980978_ChIP-Seq_HELA_Human1.83437084
21RNF2_18974828_ChIP-Seq_MESCs_Mouse1.83242310
22EZH2_18974828_ChIP-Seq_MESCs_Mouse1.83242310
23SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.79602909
24EZH2_27304074_Chip-Seq_ESCs_Mouse1.79553143
25ESR2_21235772_ChIP-Seq_MCF-7_Human1.76897508
26GBX2_23144817_ChIP-Seq_PC3_Human1.76031385
27SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.71040923
28RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.70241566
29CJUN_26792858_Chip-Seq_BT549_Human1.68851288
30EP300_21415370_ChIP-Seq_HL-1_Mouse1.67617023
31CDX2_19796622_ChIP-Seq_MESCs_Mouse1.66110814
32JARID2_20064375_ChIP-Seq_MESCs_Mouse1.63625285
33JARID2_20075857_ChIP-Seq_MESCs_Mouse1.62417205
34TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.61515004
35P300_19829295_ChIP-Seq_ESCs_Human1.59584491
36CLOCK_20551151_ChIP-Seq_293T_Human1.57797725
37MTF2_20144788_ChIP-Seq_MESCs_Mouse1.56331463
38ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.55607769
39BCAT_22108803_ChIP-Seq_LS180_Human1.54264954
40ZNF217_24962896_ChIP-Seq_MCF-7_Human1.52686377
41STAT3_23295773_ChIP-Seq_U87_Human1.52307183
42TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.47280795
43JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.46780676
44SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.44104705
45POU3F2_20337985_ChIP-ChIP_501MEL_Human1.40804339
46TP53_18474530_ChIP-ChIP_U2OS_Human1.40789724
47GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.40077472
48NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.39312154
49PCGF2_27294783_Chip-Seq_NPCs_Mouse1.38274462
50ER_23166858_ChIP-Seq_MCF-7_Human1.37624448
51PCGF2_27294783_Chip-Seq_ESCs_Mouse1.36391639
52WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.35587231
53RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.34553020
54FLI1_27457419_Chip-Seq_LIVER_Mouse1.34044539
55IKZF1_21737484_ChIP-ChIP_HCT116_Human1.31818190
56CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.31783577
57ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.31306718
58HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.30468988
59CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.27926684
60PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.25903592
61CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.25420683
62FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.24440414
63EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.24237180
64EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.24176766
65NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.24022546
66NRF2_20460467_ChIP-Seq_MEFs_Mouse1.24022546
67AR_25329375_ChIP-Seq_VCAP_Human1.23832402
68TCF4_23295773_ChIP-Seq_U87_Human1.23605751
69PIAS1_25552417_ChIP-Seq_VCAP_Human1.23458556
70TOP2B_26459242_ChIP-Seq_MCF-7_Human1.20662207
71SOX9_26525672_Chip-Seq_Limbbuds_Mouse1.19940061
72RNF2_27304074_Chip-Seq_ESCs_Mouse1.18705870
73EZH2_27294783_Chip-Seq_NPCs_Mouse1.18558653
74SMAD4_21741376_ChIP-Seq_EPCs_Human1.17106311
75EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.16693234
76AHR_22903824_ChIP-Seq_MCF-7_Human1.15592387
77* PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.15359587
78SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.15211955
79HIF1A_21447827_ChIP-Seq_MCF-7_Human1.15111526
80UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.14811970
81RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.13295848
82CDX2_22108803_ChIP-Seq_LS180_Human1.12896426
83EWS_26573619_Chip-Seq_HEK293_Human1.12356132
84KDM2B_26808549_Chip-Seq_K562_Human1.12242630
85CBX2_27304074_Chip-Seq_ESCs_Mouse1.09733323
86FUS_26573619_Chip-Seq_HEK293_Human1.09494570
87RUNX2_22187159_ChIP-Seq_PCA_Human1.09421842
88SMAD3_21741376_ChIP-Seq_EPCs_Human1.09316088
89MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.08162514
90EZH2_27294783_Chip-Seq_ESCs_Mouse1.08046277
91SOX9_24532713_ChIP-Seq_HFSC_Mouse1.07073427
92* BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.06457733
93TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.06033181
94SMC1_22415368_ChIP-Seq_MEFs_Mouse1.05493827
95CTNNB1_20460455_ChIP-Seq_HCT116_Human1.05439772
96CTBP2_25329375_ChIP-Seq_LNCAP_Human1.03733738
97SOX2_21211035_ChIP-Seq_LN229_Gbm1.02593048
98TBX20_22328084_ChIP-Seq_HEART_Mouse1.02170167
99TBX20_22080862_ChIP-Seq_HEART_Mouse1.02170167
100NANOG_18555785_Chip-Seq_ESCs_Mouse1.00996902
101OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.00430563
102NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.00170747
103BRD4_25478319_ChIP-Seq_HGPS_Human0.99961156
104SMAD4_21799915_ChIP-Seq_A2780_Human0.99948263
105NR3C1_21868756_ChIP-Seq_MCF10A_Human0.98826140
106EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.98806372
107IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.98653127
108CBP_20019798_ChIP-Seq_JUKART_Human0.98653127
109SUZ12_27294783_Chip-Seq_ESCs_Mouse0.98541026
110TP53_23651856_ChIP-Seq_MEFs_Mouse0.97967132
111* NANOG_19829295_ChIP-Seq_ESCs_Human0.97946140
112* SOX2_19829295_ChIP-Seq_ESCs_Human0.97946140
113STAT6_20620947_ChIP-Seq_CD4_POS_T_Human0.97927550
114ARNT_22903824_ChIP-Seq_MCF-7_Human0.97786504
115CTBP1_25329375_ChIP-Seq_LNCAP_Human0.97462803
116KDM2B_26808549_Chip-Seq_REH_Human0.97335632
117TP53_20018659_ChIP-ChIP_R1E_Mouse0.97096325
118RXR_22108803_ChIP-Seq_LS180_Human0.96885582
119PRDM14_20953172_ChIP-Seq_ESCs_Human0.96710205
120TCF4_22108803_ChIP-Seq_LS180_Human0.96138297
121TP53_16413492_ChIP-PET_HCT116_Human0.95760258
122FOXH1_21741376_ChIP-Seq_EPCs_Human0.95667504
123ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.95626669
124FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.94769951
125UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.94470018
126ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.94127725
127FLI1_21867929_ChIP-Seq_TH2_Mouse0.94035842
128CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.93897051
129SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.93655503
130GATA1_22025678_ChIP-Seq_K562_Human0.93321484
131CRX_20693478_ChIP-Seq_RETINA_Mouse0.93156100
132AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.92985707
133RING1B_27294783_Chip-Seq_ESCs_Mouse0.92815405
134ISL1_27105846_Chip-Seq_CPCs_Mouse0.92299574
135TCF4_18268006_ChIP-ChIP_LS174T_Human0.91696827
136WT1_25993318_ChIP-Seq_PODOCYTE_Human0.91613272
137FOXO3_23340844_ChIP-Seq_DLD1_Human0.91506284
138ERG_21242973_ChIP-ChIP_JURKAT_Human0.91195287
139PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.91066326
140TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.90812005
141POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.90280464
142TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.90280464
143* P300_27058665_Chip-Seq_ZR-75-30cells_Human0.89466305
144SUZ12_27294783_Chip-Seq_NPCs_Mouse0.88889877
145TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.88652149
146* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.88517564
147GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.88206823
148AR_19668381_ChIP-Seq_PC3_Human0.88184131
149JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.87459222
150YAP1_20516196_ChIP-Seq_MESCs_Mouse0.86080967
151NFIB_24661679_ChIP-Seq_LUNG_Mouse0.86020708

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005503_abnormal_tendon_morphology6.56551225
2MP0008438_abnormal_cutaneous_collagen4.77491644
3MP0005275_abnormal_skin_tensile4.17838546
4MP0010368_abnormal_lymphatic_system3.85328072
5MP0004134_abnormal_chest_morphology3.60696381
6MP0002933_joint_inflammation3.47500805
7MP0002282_abnormal_trachea_morphology3.37669520
8MP0003950_abnormal_plasma_membrane3.19446887
9MP0001542_abnormal_bone_strength3.13726861
10MP0009250_abnormal_appendicular_skeleto3.02203842
11* MP0000163_abnormal_cartilage_morphology2.92718418
12MP0002896_abnormal_bone_mineralization2.81373618
13* MP0002115_abnormal_skeleton_extremities2.74804592
14MP0004185_abnormal_adipocyte_glucose2.68722286
15MP0005257_abnormal_intraocular_pressure2.63934805
16MP0005508_abnormal_skeleton_morphology2.62570393
17MP0003279_aneurysm2.49614795
18MP0001879_abnormal_lymphatic_vessel2.40782505
19MP0000751_myopathy2.39807975
20MP0003705_abnormal_hypodermis_morpholog2.39110315
21MP0002108_abnormal_muscle_morphology2.35739378
22MP0003646_muscle_fatigue2.31415814
23MP0004272_abnormal_basement_membrane2.28473235
24MP0002089_abnormal_postnatal_growth/wei2.25818007
25MP0009780_abnormal_chondrocyte_physiolo2.20733429
26MP0001299_abnormal_eye_distance/2.18434288
27* MP0002113_abnormal_skeleton_development2.12811834
28MP0009384_cardiac_valve_regurgitation2.10232311
29MP0005390_skeleton_phenotype2.05368908
30MP0002998_abnormal_bone_remodeling2.04162651
31* MP0002109_abnormal_limb_morphology1.89232797
32MP0001958_emphysema1.88135945
33MP0002249_abnormal_larynx_morphology1.83622422
34MP0005171_absent_coat_pigmentation1.83236516
35MP0001533_abnormal_skeleton_physiology1.82173345
36MP0003195_calcinosis1.72553125
37MP0000013_abnormal_adipose_tissue1.69377227
38MP0002102_abnormal_ear_morphology1.66992923
39MP0000762_abnormal_tongue_morphology1.62827954
40MP0001270_distended_abdomen1.60745571
41MP0008775_abnormal_heart_ventricle1.57870207
42MP0003566_abnormal_cell_adhesion1.54981919
43MP0003795_abnormal_bone_structure1.53951024
44MP0001661_extended_life_span1.46085074
45MP0005666_abnormal_adipose_tissue1.45981300
46MP0002233_abnormal_nose_morphology1.45537742
47MP0002168_other_aberrant_phenotype1.44734947
48MP0000428_abnormal_craniofacial_morphol1.44646448
49MP0006054_spinal_hemorrhage1.42407726
50MP0002254_reproductive_system_inflammat1.38887728
51MP0006072_abnormal_retinal_apoptosis1.37949542
52MP0003045_fibrosis1.37412668
53MP0002116_abnormal_craniofacial_bone1.36979472
54MP0003011_delayed_dark_adaptation1.31782116
55MP0003283_abnormal_digestive_organ1.31773564
56MP0003755_abnormal_palate_morphology1.31693915
57MP0005360_urolithiasis1.30644887
58MP0005023_abnormal_wound_healing1.28257016
59MP0005623_abnormal_meninges_morphology1.27581679
60MP0002060_abnormal_skin_morphology1.27263884
61MP0005551_abnormal_eye_electrophysiolog1.27067335
62MP0000432_abnormal_head_morphology1.25591334
63MP0002932_abnormal_joint_morphology1.25444385
64MP0010030_abnormal_orbit_morphology1.24257251
65MP0003937_abnormal_limbs/digits/tail_de1.24070110
66MP0005167_abnormal_blood-brain_barrier1.23036208
67MP0003935_abnormal_craniofacial_develop1.18254041
68MP0002837_dystrophic_cardiac_calcinosis1.17482572
69MP0000049_abnormal_middle_ear1.13521749
70MP0002876_abnormal_thyroid_physiology1.12495599
71MP0000566_synostosis1.11475198
72MP0005253_abnormal_eye_physiology1.08973282
73MP0000230_abnormal_systemic_arterial1.06921227
74MP0003385_abnormal_body_wall1.05284799
75MP0010386_abnormal_urinary_bladder1.02281777
76MP0002114_abnormal_axial_skeleton1.01959702
77MP0000569_abnormal_digit_pigmentation1.00795458
78MP0002938_white_spotting1.00465260
79MP0005410_abnormal_fertilization0.99518252
80MP0000427_abnormal_hair_cycle0.98766346
81MP0001501_abnormal_sleep_pattern0.97990057
82MP0003123_paternal_imprinting0.97294133
83MP0004858_abnormal_nervous_system0.96417214
84MP0005620_abnormal_muscle_contractility0.95957754
85MP0004215_abnormal_myocardial_fiber0.95655974
86MP0003942_abnormal_urinary_system0.94741681
87MP0003122_maternal_imprinting0.91824485
88MP0004043_abnormal_pH_regulation0.88943988
89MP0000749_muscle_degeneration0.88444057
90MP0003091_abnormal_cell_migration0.87852644
91MP0002909_abnormal_adrenal_gland0.87798630
92MP0004085_abnormal_heartbeat0.87722845
93MP0001348_abnormal_lacrimal_gland0.87509633
94MP0004084_abnormal_cardiac_muscle0.87249725
95MP0002111_abnormal_tail_morphology0.85822578
96MP0008875_abnormal_xenobiotic_pharmacok0.85305938
97MP0005369_muscle_phenotype0.83487485
98MP0005395_other_phenotype0.83198759
99MP0009046_muscle_twitch0.82431063
100MP0005375_adipose_tissue_phenotype0.81021446
101MP0003115_abnormal_respiratory_system0.80918847
102MP0000750_abnormal_muscle_regeneration0.80900084
103MP0002972_abnormal_cardiac_muscle0.80637774
104MP0001986_abnormal_taste_sensitivity0.80336238
105MP0005076_abnormal_cell_differentiation0.79927602
106MP0005377_hearing/vestibular/ear_phenot0.79877890
107MP0003878_abnormal_ear_physiology0.79877890
108MP0002332_abnormal_exercise_endurance0.77318049
109MP0005165_increased_susceptibility_to0.76216520
110MP0000733_abnormal_muscle_development0.74477021
111MP0002234_abnormal_pharynx_morphology0.73545930
112MP0001614_abnormal_blood_vessel0.71727937
113MP0004484_altered_response_of0.69346264
114MP0005248_abnormal_Harderian_gland0.68848328
115MP0004142_abnormal_muscle_tone0.68293958
116MP0000462_abnormal_digestive_system0.66841902
117MP0000003_abnormal_adipose_tissue0.66532173
118MP0004510_myositis0.65168447
119MP0003787_abnormal_imprinting0.64979786
120MP0009053_abnormal_anal_canal0.64163449
121MP0005084_abnormal_gallbladder_morpholo0.63591625
122MP0008877_abnormal_DNA_methylation0.63260840
123MP0005330_cardiomyopathy0.62903078
124MP0001756_abnormal_urination0.62853616
125MP0004087_abnormal_muscle_fiber0.62773540
126MP0002653_abnormal_ependyma_morphology0.61950692
127MP0005367_renal/urinary_system_phenotyp0.61800889
128MP0000516_abnormal_urinary_system0.61800889
129MP0005451_abnormal_body_composition0.61526254
130MP0002272_abnormal_nervous_system0.60682638
131MP0001243_abnormal_dermal_layer0.60045834
132MP0000613_abnormal_salivary_gland0.59965426
133MP0000534_abnormal_ureter_morphology0.58972534
134MP0006292_abnormal_olfactory_placode0.57567101
135MP0001849_ear_inflammation0.57422918
136MP0003303_peritoneal_inflammation0.57297061
137MP0004885_abnormal_endolymph0.56105666
138MP0004036_abnormal_muscle_relaxation0.55232043
139MP0005670_abnormal_white_adipose0.54583922
140MP0000767_abnormal_smooth_muscle0.53804572
141MP0009703_decreased_birth_body0.53792531
142MP0002295_abnormal_pulmonary_circulatio0.53731992
143MP0005595_abnormal_vascular_smooth0.53687962
144MP0000759_abnormal_skeletal_muscle0.52535643
145MP0005164_abnormal_response_to0.52118288
146MP0002128_abnormal_blood_circulation0.52037822
147MP0004197_abnormal_fetal_growth/weight/0.51625412
148MP0003252_abnormal_bile_duct0.51621621
149MP0001915_intracranial_hemorrhage0.51041971
150MP0005381_digestive/alimentary_phenotyp0.49877771
151MP0000747_muscle_weakness0.49643332
152MP0004145_abnormal_muscle_electrophysio0.48332324
153MP0009672_abnormal_birth_weight0.48316319

Predicted human phenotypes

RankGene SetZ-score
1Epiphyseal dysplasia (HP:0002656)8.19678186
2Irregular epiphyses (HP:0010582)6.72914970
3Small epiphyses (HP:0010585)6.33281409
4Hypoplastic ischia (HP:0003175)6.02512560
5Vitreoretinal degeneration (HP:0000655)5.55550079
6Abnormality of the ischium (HP:0003174)5.34415150
7Cupped ribs (HP:0000887)5.05952183
8Aplasia/Hypoplasia of the pubic bone (HP:0009104)4.96811295
9Neonatal short-limb short stature (HP:0008921)4.65682878
10Abnormal tarsal ossification (HP:0008369)4.52452857
11Flat capital femoral epiphysis (HP:0003370)4.30029693
12Metaphyseal cupping (HP:0003021)4.26588212
13Mild short stature (HP:0003502)4.17494946
14Protrusio acetabuli (HP:0003179)4.08518698
15Delayed epiphyseal ossification (HP:0002663)4.04599909
16Osteoarthritis (HP:0002758)3.97878318
17Genu varum (HP:0002970)3.92941568
18Flattened epiphyses (HP:0003071)3.75078653
19Flat acetabular roof (HP:0003180)3.72401711
20Increased corneal curvature (HP:0100692)3.52493460
21Keratoconus (HP:0000563)3.52493460
22Soft skin (HP:0000977)3.51261437
23Abnormality of the vertebral endplates (HP:0005106)3.49086116
24Abnormal foot bone ossification (HP:0010675)3.39012936
25Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)3.37577424
26Absent epiphyses (HP:0010577)3.37577424
27Aortic dissection (HP:0002647)3.35056478
28Premature rupture of membranes (HP:0001788)3.34452944
29Abnormality of femoral epiphyses (HP:0006499)3.31187940
30Abnormality involving the epiphyses of the lower limbs (HP:0006500)3.31187940
31Irregular vertebral endplates (HP:0003301)3.23870032
32Cervical subluxation (HP:0003308)3.23296055
33Mesomelia (HP:0003027)3.16910362
34Coxa vara (HP:0002812)3.12260928
35Platyspondyly (HP:0000926)3.03859677
36Ulnar bowing (HP:0003031)3.00945003
37Aplasia of the musculature (HP:0100854)2.97686351
38Abnormality of the epiphysis of the femoral head (HP:0010574)2.95299514
39Spinal rigidity (HP:0003306)2.94186055
40Vascular tortuosity (HP:0004948)2.89902744
41Abnormality of the phalanges of the 2nd finger (HP:0009541)2.86472405
42Hip contracture (HP:0003273)2.84040168
43Exostoses (HP:0100777)2.83265480
44Short femoral neck (HP:0100864)2.82047546
45Limited hip movement (HP:0008800)2.80805434
46Ankle contracture (HP:0006466)2.75491907
47Limited elbow extension (HP:0001377)2.72465291
48Ulnar claw (HP:0001178)2.72164988
49Vertebral clefting (HP:0008428)2.71489380
50Abnormality of the pubic bones (HP:0003172)2.71230536
51Arterial tortuosity (HP:0005116)2.70204049
52Abnormality of the femoral head (HP:0003368)2.67822674
53Thin ribs (HP:0000883)2.67817895
54Metaphyseal dysplasia (HP:0100255)2.67339732
55Spondylolisthesis (HP:0003302)2.67280431
56Abnormality of midbrain morphology (HP:0002418)2.65923148
57Molar tooth sign on MRI (HP:0002419)2.65923148
58Wrist flexion contracture (HP:0001239)2.65061355
59Absent frontal sinuses (HP:0002688)2.64454656
60Abnormality of carpal bone ossification (HP:0006257)2.62628075
61Protuberant abdomen (HP:0001538)2.59177216
62Lumbar hyperlordosis (HP:0002938)2.58290409
63Aplasia/Hypoplasia involving the femoral head and neck (HP:0009108)2.57788674
64Congenital stationary night blindness (HP:0007642)2.57077544
65Radial bowing (HP:0002986)2.56827209
66Follicular hyperkeratosis (HP:0007502)2.55317864
67Hand muscle atrophy (HP:0009130)2.55002706
68Waddling gait (HP:0002515)2.54547683
69Abnormality of the proximal phalanges of the hand (HP:0009834)2.53433409
70Abnormal vertebral ossification (HP:0100569)2.52352877
71Type 1 muscle fiber predominance (HP:0003803)2.52117593
72Arthropathy (HP:0003040)2.52020253
73Aortic aneurysm (HP:0004942)2.47986935
74Enlarged epiphyses (HP:0010580)2.46705557
75Spinal cord compression (HP:0002176)2.44255615
76Metaphyseal irregularity (HP:0003025)2.43753722
77Slender build (HP:0001533)2.43495055
78Rhizomelia (HP:0008905)2.42493870
79Broad metatarsal (HP:0001783)2.39996309
80J-shaped sella turcica (HP:0002680)2.38800318
81Type II lissencephaly (HP:0007260)2.38155045
82Cerebral aneurysm (HP:0004944)2.34917478
83Hypoventilation (HP:0002791)2.32850528
84Joint stiffness (HP:0001387)2.31847424
85Thoracolumbar scoliosis (HP:0002944)2.31206316
86Genu recurvatum (HP:0002816)2.30911184
87Broad long bones (HP:0005622)2.30911153
88Abnormal ossification of hand bones (HP:0005921)2.30655661
89Abnormal hand bone ossification (HP:0010660)2.29629995
90Distal upper limb amyotrophy (HP:0007149)2.29617398
91Upper limb amyotrophy (HP:0009129)2.29617398
92Ovoid vertebral bodies (HP:0003300)2.28053373
93Aplasia/Hypoplasia involving the musculature (HP:0001460)2.27969434
94Bladder diverticulum (HP:0000015)2.27154144
95Aplasia/Hypoplasia involving the pelvis (HP:0009103)2.27025652
96Nephronophthisis (HP:0000090)2.25665524
97Pancreatic cysts (HP:0001737)2.24205799
98Pancreatic fibrosis (HP:0100732)2.19402393
99Upper limb muscle weakness (HP:0003484)2.19208395
100Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)2.17541971
101Abnormality of dentin (HP:0010299)2.17070879
102Congenital, generalized hypertrichosis (HP:0004540)2.16893399
103Abnormality of the middle phalanges of the toes (HP:0010183)2.15855228
104Aplasia/hypoplasia of the femur (HP:0005613)2.15594668
105Long clavicles (HP:0000890)2.15355419
106Flared metaphyses (HP:0003015)2.14973924
107Mildly elevated creatine phosphokinase (HP:0008180)2.14635577
108Peritonitis (HP:0002586)2.14253141
109Bowed forearm bones (HP:0003956)2.14150916
110Bowing of the arm (HP:0006488)2.14150916
111Hypoplasia of the odontoid process (HP:0003311)2.13708124
112Bell-shaped thorax (HP:0001591)2.13703540
113Barrel-shaped chest (HP:0001552)2.13390251
114Stillbirth (HP:0003826)2.13113322
115Abnormality of the renal medulla (HP:0100957)2.12373498
116Cardiovascular calcification (HP:0011915)2.11881005
117Broad phalanx (HP:0006009)2.11819799
118Conical tooth (HP:0000698)2.11701038
119Biconcave vertebral bodies (HP:0004586)2.11572462
120Hypoplasia of the capital femoral epiphysis (HP:0003090)2.10687574
121Wormian bones (HP:0002645)2.10473844
122Abnormality of the 2nd finger (HP:0004100)2.09518472
123Bulbous nose (HP:0000414)2.09232682
124Tibial bowing (HP:0002982)2.09130545
125Beaking of vertebral bodies (HP:0004568)2.08917138
126Neonatal respiratory distress (HP:0002643)2.07812706
127Aplasia/Hypoplasia of the tongue (HP:0010295)2.06394374
128Aortic valve stenosis (HP:0001650)2.05503382
129Attenuation of retinal blood vessels (HP:0007843)2.05344703
130Micromelia (HP:0002983)2.05283826
131Abnormality of the acetabulum (HP:0003170)2.04164241
132True hermaphroditism (HP:0010459)2.03537538
133Mixed hearing impairment (HP:0000410)2.01321200
134Broad thumb (HP:0011304)2.00608049
135Infantile muscular hypotonia (HP:0008947)1.99885671
136Femoral bowing (HP:0002980)1.98820060
137Ectopia lentis (HP:0001083)1.98806632
138Tubular atrophy (HP:0000092)1.97410340
139Fibular hypoplasia (HP:0003038)1.96825940
140Abnormality of incisor morphology (HP:0011063)1.96540253
141Short middle phalanx of finger (HP:0005819)1.95930266
142Aplasia/Hypoplasia of the tibia (HP:0005772)1.95807404
143Mitral valve prolapse (HP:0001634)1.95229264
144Shallow orbits (HP:0000586)1.95127267
145Elbow flexion contracture (HP:0002987)1.93688422
146Mesangial abnormality (HP:0001966)1.93108132
147Recurrent corneal erosions (HP:0000495)1.92903651
148Large for gestational age (HP:0001520)1.92600587
149Blue sclerae (HP:0000592)1.92444001
150Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.92047680
151Disproportionate short-trunk short stature (HP:0003521)1.88817830
152Bradycardia (HP:0001662)1.88792213
153Abnormality of the calf musculature (HP:0001430)1.84799518
154Adactyly (HP:0009776)1.84644019
155Pigmentary retinal degeneration (HP:0001146)1.83741495
156Small hand (HP:0200055)1.82491383
157Anterior segment dysgenesis (HP:0007700)1.80991540
158Fatigable weakness (HP:0003473)1.79309899
159Abnormality of the neuromuscular junction (HP:0003398)1.79309899
160Stage 5 chronic kidney disease (HP:0003774)1.78536089
161Occipital encephalocele (HP:0002085)1.78476836
162Protruding ear (HP:0000411)1.76544874
163Hypoplasia of the iris (HP:0007676)1.75903921
164Pulmonary artery stenosis (HP:0004415)1.75509404
165Slender long bone (HP:0003100)1.74675691
166Decreased subcutaneous fat (HP:0001002)1.73010616
167Atrophic scars (HP:0001075)1.70064920

Predicted kinase interactions (KEA)

RankGene SetZ-score
1DDR28.73340264
2TIE15.34114421
3FRK5.29035777
4SIK14.00570177
5NTRK33.35038233
6LATS12.82941036
7LMTK22.81936366
8TRIB32.80616136
9TNIK2.65198688
10PTK2B2.58428261
11ADRBK22.41662560
12PKN22.40592733
13MAP3K32.10099529
14MOS2.05525367
15STK242.02397956
16EPHA41.98916530
17BMPR1B1.97409309
18STK38L1.94898914
19CDK121.90199745
20FLT31.65699476
21PINK11.65464865
22MAP4K21.64314789
23GRK11.59192228
24MAPKAPK31.58158363
25NTRK11.56662565
26LIMK11.56024318
27ZAK1.46891857
28TTN1.46883689
29EPHB11.45984745
30TAOK11.35281481
31FGFR11.34322210
32ERN11.33008401
33PDGFRA1.31545613
34NLK1.29850059
35EEF2K1.29566387
36DAPK21.28895039
37PTK61.25278478
38WNK41.24616523
39STK31.23842842
40MYLK1.19351055
41MAP3K61.18659881
42ACVR1B1.16971282
43RIPK11.16583451
44INSRR1.16464357
45PRKG21.14705460
46PRKCE1.13615341
47WNK31.10254509
48PAK31.08946180
49MAPK121.06479718
50EPHA31.05125837
51TGFBR11.03648812
52BMX0.98766955
53PDGFRB0.98007619
54ROCK10.97046140
55LATS20.97045368
56LRRK20.96772296
57PRKD30.94320287
58FGFR20.94004504
59TLK10.93750833
60TRPM70.93137001
61KIT0.90223272
62JAK10.88410179
63PAK60.87656839
64STK380.84484347
65ADRBK10.83378291
66EPHB20.82264145
67ROCK20.81866270
68MUSK0.78452596
69STK390.76665654
70BRD40.76625251
71MAP3K100.76460319
72PRKCH0.76220771
73MAP3K70.75787633
74MAPK130.75766719
75PRKD20.75445368
76MST1R0.73400529
77NUAK10.72614116
78FGFR30.72003377
79KDR0.71018156
80RET0.68286442
81FER0.64378922
82MARK20.63740955
83SGK30.62408066
84NME10.61785666
85PLK20.61542422
86EPHA20.60985025
87PAK40.60490125
88MAPK70.59454170
89PRKCQ0.58807359
90CAMK1G0.56987488
91CAMKK10.56171316
92PIK3CG0.56142632
93SGK20.55337317
94CAMKK20.54294656
95DYRK1A0.54258109
96PIM20.54205079
97CAMK1D0.54120909
98CAMK2A0.54087800
99RPS6KB10.53573932
100OXSR10.51527939
101NEK90.50277428
102MTOR0.48965491
103FES0.48474134
104BCKDK0.48372502
105AKT30.47866329
106WNK10.47222408
107CAMK2D0.46880769
108SGK10.46837773
109DMPK0.46646113
110CDK60.45992532
111INSR0.45961870
112PHKG10.45223840
113PHKG20.45223840
114MAP2K10.43699503
115IGF1R0.43617338
116CASK0.42923032
117CDC42BPA0.42873308
118CHUK0.42869698
119ABL10.41922921
120PRKCG0.41753235
121ABL20.41441854
122GRK50.41386402
123ILK0.40574904
124TGFBR20.39440231
125CSNK1G10.38968771
126PRKAA20.38830657
127MAP3K40.38639007
128MET0.37642933
129FGFR40.36371396
130MAP3K50.36283620
131PRKAA10.36045177
132OBSCN0.35768335
133ERBB40.35581196
134TAOK20.34993792
135HIPK20.34963818
136CAMK40.34697760
137PKN10.34055252
138PTK20.34035233
139PRKG10.33932257
140HCK0.33813623
141GSK3A0.33626320
142NME20.33077228
143CSF1R0.31987720
144NEK20.31898265
145IKBKB0.31260315
146STK100.30522173
147PRKD10.29038917
148PAK20.28954619
149MKNK20.28901414
150MAP2K30.28493298
151CAMK10.28231567
152PRKCI0.27505680
153EIF2AK30.27024693

Predicted pathways (KEGG)

RankGene SetZ-score
1* ECM-receptor interaction_Homo sapiens_hsa045125.77925478
2Protein digestion and absorption_Homo sapiens_hsa049744.78697757
3Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005324.21913930
4* Focal adhesion_Homo sapiens_hsa045102.73919642
5Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.69451571
6Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.42243020
7Glycosaminoglycan degradation_Homo sapiens_hsa005312.40484289
8Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006042.32811378
9Phototransduction_Homo sapiens_hsa047442.08086039
10Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006012.04839483
11Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.03166004
12Basal cell carcinoma_Homo sapiens_hsa052171.97649111
13Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.95222786
14Nitrogen metabolism_Homo sapiens_hsa009101.95068785
15ABC transporters_Homo sapiens_hsa020101.91502080
16Malaria_Homo sapiens_hsa051441.71797811
17Lysine degradation_Homo sapiens_hsa003101.62696048
18Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.59046560
19Proteoglycans in cancer_Homo sapiens_hsa052051.57923251
20Cyanoamino acid metabolism_Homo sapiens_hsa004601.55032708
21* PI3K-Akt signaling pathway_Homo sapiens_hsa041511.51720159
22Linoleic acid metabolism_Homo sapiens_hsa005911.49539531
23alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.48623174
24Starch and sucrose metabolism_Homo sapiens_hsa005001.48173746
25Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.45604961
26TGF-beta signaling pathway_Homo sapiens_hsa043501.43683877
27* Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.38170656
28Selenocompound metabolism_Homo sapiens_hsa004501.30266136
29* Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.27104709
30Ether lipid metabolism_Homo sapiens_hsa005651.26473642
31* Dilated cardiomyopathy_Homo sapiens_hsa054141.22749102
32SNARE interactions in vesicular transport_Homo sapiens_hsa041301.21419614
33Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.19174693
34Dorso-ventral axis formation_Homo sapiens_hsa043201.16056687
35Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.14468343
36Hedgehog signaling pathway_Homo sapiens_hsa043401.13890504
37AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.13672285
38Tryptophan metabolism_Homo sapiens_hsa003801.12883587
39Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.08249782
40Vascular smooth muscle contraction_Homo sapiens_hsa042701.07592727
41Basal transcription factors_Homo sapiens_hsa030221.06628603
42Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.04065991
43Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.03342392
44Insulin resistance_Homo sapiens_hsa049311.02299783
45Complement and coagulation cascades_Homo sapiens_hsa046101.00483079
46cGMP-PKG signaling pathway_Homo sapiens_hsa040220.99275248
47Mineral absorption_Homo sapiens_hsa049780.98801982
48Taste transduction_Homo sapiens_hsa047420.98045732
49Steroid biosynthesis_Homo sapiens_hsa001000.97713277
50Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.96873146
51Hippo signaling pathway_Homo sapiens_hsa043900.96284950
52Aldosterone synthesis and secretion_Homo sapiens_hsa049250.93722857
53Amoebiasis_Homo sapiens_hsa051460.93694306
54Wnt signaling pathway_Homo sapiens_hsa043100.92064518
55Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.91685700
56Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.91388484
57Type II diabetes mellitus_Homo sapiens_hsa049300.91155460
58Melanoma_Homo sapiens_hsa052180.90379540
59Histidine metabolism_Homo sapiens_hsa003400.88294087
60Estrogen signaling pathway_Homo sapiens_hsa049150.88131829
61MicroRNAs in cancer_Homo sapiens_hsa052060.88040877
62Regulation of autophagy_Homo sapiens_hsa041400.86004740
63Circadian rhythm_Homo sapiens_hsa047100.85571628
64Adipocytokine signaling pathway_Homo sapiens_hsa049200.85258547
65Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.83673634
66PPAR signaling pathway_Homo sapiens_hsa033200.83621908
67Bladder cancer_Homo sapiens_hsa052190.83025815
68Adherens junction_Homo sapiens_hsa045200.82955280
69Steroid hormone biosynthesis_Homo sapiens_hsa001400.82433273
70Circadian entrainment_Homo sapiens_hsa047130.82136007
71Chemical carcinogenesis_Homo sapiens_hsa052040.82049152
72Thyroid hormone synthesis_Homo sapiens_hsa049180.81892312
73Longevity regulating pathway - mammal_Homo sapiens_hsa042110.81605804
74Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.80211472
75Bile secretion_Homo sapiens_hsa049760.80107456
76Ovarian steroidogenesis_Homo sapiens_hsa049130.80035550
77Melanogenesis_Homo sapiens_hsa049160.79095251
78Chronic myeloid leukemia_Homo sapiens_hsa052200.77979678
79Nicotine addiction_Homo sapiens_hsa050330.77889857
80Sulfur relay system_Homo sapiens_hsa041220.77349583
81N-Glycan biosynthesis_Homo sapiens_hsa005100.76941572
82Prostate cancer_Homo sapiens_hsa052150.76398155
83Protein export_Homo sapiens_hsa030600.75377423
84Axon guidance_Homo sapiens_hsa043600.75217158
85Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.74937537
86Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.74313744
87Glutamatergic synapse_Homo sapiens_hsa047240.73857427
88Glucagon signaling pathway_Homo sapiens_hsa049220.73326069
89mTOR signaling pathway_Homo sapiens_hsa041500.72975209
90Central carbon metabolism in cancer_Homo sapiens_hsa052300.72591140
91Long-term depression_Homo sapiens_hsa047300.72355269
92Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.71397991
93Glioma_Homo sapiens_hsa052140.70778957
94Pentose and glucuronate interconversions_Homo sapiens_hsa000400.68889801
95Sulfur metabolism_Homo sapiens_hsa009200.67806859
96Butanoate metabolism_Homo sapiens_hsa006500.67683004
97Insulin secretion_Homo sapiens_hsa049110.66880376
98Thyroid hormone signaling pathway_Homo sapiens_hsa049190.66595532
99cAMP signaling pathway_Homo sapiens_hsa040240.65060890
100Serotonergic synapse_Homo sapiens_hsa047260.62273337
101Salivary secretion_Homo sapiens_hsa049700.61993033
102Sphingolipid metabolism_Homo sapiens_hsa006000.61648410
103Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.61239189
104Arginine and proline metabolism_Homo sapiens_hsa003300.60877817
105Insulin signaling pathway_Homo sapiens_hsa049100.60274620
106Amphetamine addiction_Homo sapiens_hsa050310.59999118
107Notch signaling pathway_Homo sapiens_hsa043300.59855719
108VEGF signaling pathway_Homo sapiens_hsa043700.59622211
109beta-Alanine metabolism_Homo sapiens_hsa004100.59189071
110Propanoate metabolism_Homo sapiens_hsa006400.59095959
111Oxytocin signaling pathway_Homo sapiens_hsa049210.58397906
112Platelet activation_Homo sapiens_hsa046110.57360925
113Small cell lung cancer_Homo sapiens_hsa052220.54759171
114Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.52384600
115Pancreatic cancer_Homo sapiens_hsa052120.52091036
116Choline metabolism in cancer_Homo sapiens_hsa052310.51528149
117HIF-1 signaling pathway_Homo sapiens_hsa040660.50487057
118Ras signaling pathway_Homo sapiens_hsa040140.50308961
119Glycerolipid metabolism_Homo sapiens_hsa005610.50164852
120GnRH signaling pathway_Homo sapiens_hsa049120.49191510
121ErbB signaling pathway_Homo sapiens_hsa040120.48456000
122Renin secretion_Homo sapiens_hsa049240.48143645
123Caffeine metabolism_Homo sapiens_hsa002320.47932318
124HTLV-I infection_Homo sapiens_hsa051660.47208989
125Neurotrophin signaling pathway_Homo sapiens_hsa047220.46066269
126Cocaine addiction_Homo sapiens_hsa050300.45789524
127Morphine addiction_Homo sapiens_hsa050320.45637685
128Calcium signaling pathway_Homo sapiens_hsa040200.45198787
129Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.43878257
130Fanconi anemia pathway_Homo sapiens_hsa034600.43460370
131Cholinergic synapse_Homo sapiens_hsa047250.43254420
132* Regulation of actin cytoskeleton_Homo sapiens_hsa048100.42367419
133GABAergic synapse_Homo sapiens_hsa047270.42282609
134Colorectal cancer_Homo sapiens_hsa052100.41764137
135Galactose metabolism_Homo sapiens_hsa000520.41372229
136Primary bile acid biosynthesis_Homo sapiens_hsa001200.41187503
137Endometrial cancer_Homo sapiens_hsa052130.40944993
138Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.40793992
139Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.40177403
140Long-term potentiation_Homo sapiens_hsa047200.38889004
141Arachidonic acid metabolism_Homo sapiens_hsa005900.38874129
142Olfactory transduction_Homo sapiens_hsa047400.38838535
143TNF signaling pathway_Homo sapiens_hsa046680.38739018
144Pathways in cancer_Homo sapiens_hsa052000.38705999
145p53 signaling pathway_Homo sapiens_hsa041150.38129312
146Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.37384895
147Phospholipase D signaling pathway_Homo sapiens_hsa040720.36942680
148Glutathione metabolism_Homo sapiens_hsa004800.34992660
149Cardiac muscle contraction_Homo sapiens_hsa042600.33130194
150Lysosome_Homo sapiens_hsa041420.32468107
151Jak-STAT signaling pathway_Homo sapiens_hsa046300.31952344
152Peroxisome_Homo sapiens_hsa041460.31742928
153Retinol metabolism_Homo sapiens_hsa008300.29215196

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