ITGA2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes the alpha subunit of a transmembrane receptor for collagens and related proteins. The encoded protein forms a heterodimer with a beta subunit and mediates the adhesion of platelets and other cell types to the extracellular matrix. Loss of the encoded protein is associated with bleeding disorder platelet-type 9. Antibodies against this protein are found in several immune disorders, including neonatal alloimmune thrombocytopenia. This gene is located adjacent to a related alpha subunit gene. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1hemidesmosome assembly (GO:0031581)7.83907650
2hepatocyte apoptotic process (GO:0097284)6.13225066
3* mesodermal cell differentiation (GO:0048333)5.84142961
4interferon-gamma secretion (GO:0072643)5.15969550
5renal filtration (GO:0097205)5.10671750
6Golgi transport vesicle coating (GO:0048200)4.30635323
7COPI coating of Golgi vesicle (GO:0048205)4.30635323
8cell-substrate junction assembly (GO:0007044)4.30296595
9* cell adhesion mediated by integrin (GO:0033627)4.21592597
10lung lobe morphogenesis (GO:0060463)4.21129351
11glial cell proliferation (GO:0014009)4.07394399
12positive regulation of establishment of protein localization to plasma membrane (GO:0090004)4.00267070
13maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.94369554
14respiratory tube development (GO:0030323)3.91507218
15negative regulation of chondrocyte differentiation (GO:0032331)3.80321512
16cellular response to vitamin D (GO:0071305)3.78456060
17lung epithelium development (GO:0060428)3.78021317
18positive regulation of protein localization to plasma membrane (GO:1903078)3.77505598
19regulation of vascular endothelial growth factor signaling pathway (GO:1900746)3.71104320
20cytoskeletal anchoring at plasma membrane (GO:0007016)3.63533861
21establishment of endothelial barrier (GO:0061028)3.62301987
22* skin morphogenesis (GO:0043589)3.61566103
23regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)3.57057741
24wound healing, spreading of epidermal cells (GO:0035313)3.55584847
25muscle cell migration (GO:0014812)3.55468261
26protein retention in ER lumen (GO:0006621)3.49590958
27regulation of metalloenzyme activity (GO:0048552)3.48727322
28bundle of His cell to Purkinje myocyte communication (GO:0086069)3.48017776
29positive regulation of osteoblast proliferation (GO:0033690)3.45559719
30hippo signaling (GO:0035329)3.43304812
31membrane raft organization (GO:0031579)3.41346724
32diterpenoid biosynthetic process (GO:0016102)3.39377782
33lens fiber cell development (GO:0070307)3.37296079
34growth hormone receptor signaling pathway (GO:0060396)3.36446878
35COPII vesicle coating (GO:0048208)3.31381877
36organ formation (GO:0048645)3.29343718
37positive regulation of Rho protein signal transduction (GO:0035025)3.28128023
38surfactant homeostasis (GO:0043129)3.23389525
39regulation of nephron tubule epithelial cell differentiation (GO:0072182)3.21643484
40epithelial cell-cell adhesion (GO:0090136)3.21144157
41cellular response to vitamin (GO:0071295)3.20338099
42embryonic foregut morphogenesis (GO:0048617)3.19221173
43desmosome organization (GO:0002934)3.17377108
44regulation of water loss via skin (GO:0033561)3.15731382
45endodermal cell differentiation (GO:0035987)3.14178092
46mammary gland epithelial cell proliferation (GO:0033598)3.12695664
47lung vasculature development (GO:0060426)3.12524725
48cell migration involved in sprouting angiogenesis (GO:0002042)3.10320531
49dichotomous subdivision of an epithelial terminal unit (GO:0060600)3.09399977
50regulation of epithelial cell differentiation involved in kidney development (GO:2000696)3.08078685
51tight junction assembly (GO:0070830)3.06306553
52lymphangiogenesis (GO:0001946)3.00906554
53negative regulation of fibrinolysis (GO:0051918)3.00063751
54regulation of transforming growth factor beta2 production (GO:0032909)2.97889772
55thrombin receptor signaling pathway (GO:0070493)2.96208244
56negative regulation of epidermal growth factor-activated receptor activity (GO:0007175)2.96008581
57establishment of skin barrier (GO:0061436)2.95853691
58regulation of keratinocyte proliferation (GO:0010837)2.94929382
59lung-associated mesenchyme development (GO:0060484)2.94764592
60gap junction assembly (GO:0016264)2.93837905
61regulation of glomerular filtration (GO:0003093)2.92124481
62kidney morphogenesis (GO:0060993)2.91333951
63regulation of transforming growth factor beta production (GO:0071634)2.90938636
64wound healing, spreading of cells (GO:0044319)2.90706933
65fibrinolysis (GO:0042730)2.90450436
66cellular response to growth hormone stimulus (GO:0071378)2.90170819
67retina vasculature morphogenesis in camera-type eye (GO:0061299)2.89298239
68membrane budding (GO:0006900)2.89011819
69intestinal epithelial cell development (GO:0060576)2.88844851
70activation of Rac GTPase activity (GO:0032863)2.88806374
71substrate adhesion-dependent cell spreading (GO:0034446)2.85509163
72adherens junction assembly (GO:0034333)2.84927575
73decidualization (GO:0046697)2.84821226
74polarized epithelial cell differentiation (GO:0030859)2.83451134
75positive regulation of extracellular matrix organization (GO:1903055)2.83210350
76positive regulation of actin filament depolymerization (GO:0030836)2.80081268
77regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)2.79717158
78protein hydroxylation (GO:0018126)2.75429692
79negative regulation of fatty acid transport (GO:2000192)2.75100879
80positive regulation of interleukin-8 secretion (GO:2000484)2.74934578
81membrane protein ectodomain proteolysis (GO:0006509)2.74188227
82protein localization to endosome (GO:0036010)2.74151641
83cell differentiation involved in embryonic placenta development (GO:0060706)2.73476423
84positive regulation of tolerance induction (GO:0002645)2.73214870
85cell junction assembly (GO:0034329)2.72300510
86regulation of chemokine secretion (GO:0090196)2.70272239
87regulation of plasminogen activation (GO:0010755)2.69780245
88renal system development (GO:0072001)2.69744256
89positive regulation of blood vessel endothelial cell migration (GO:0043536)2.68758004
90positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003602.68113445
91regulation of podosome assembly (GO:0071801)2.67093719
92negative regulation of keratinocyte proliferation (GO:0010839)2.65988627
93stress fiber assembly (GO:0043149)2.63697427
94positive regulation of astrocyte differentiation (GO:0048711)2.63457010
95* hypotonic response (GO:0006971)2.63448564
96negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.62464881
97tyrosine phosphorylation of STAT protein (GO:0007260)2.62426833
98semaphorin-plexin signaling pathway (GO:0071526)2.62016830
99* substrate-dependent cell migration (GO:0006929)2.60857153
100branching involved in salivary gland morphogenesis (GO:0060445)2.60638605
101endocardial cushion development (GO:0003197)2.60196979
102establishment of planar polarity (GO:0001736)2.59712408
103establishment of tissue polarity (GO:0007164)2.59712408
104keratinocyte differentiation (GO:0030216)2.59310903
105branching involved in mammary gland duct morphogenesis (GO:0060444)2.59094966
106regulation of branching involved in salivary gland morphogenesis (GO:0060693)2.58695989
107regulation of epidermal growth factor-activated receptor activity (GO:0007176)2.58410600
108cell junction organization (GO:0034330)2.57766035
109negative regulation of stem cell proliferation (GO:2000647)2.57319657
110keratinocyte proliferation (GO:0043616)2.57056282
111cellular copper ion homeostasis (GO:0006878)2.56930967
112endothelial cell morphogenesis (GO:0001886)2.56296779
113regulation of T cell tolerance induction (GO:0002664)2.55790505
114regulation of osteoblast proliferation (GO:0033688)2.55097564
115collagen metabolic process (GO:0032963)2.54960892
116chondrocyte proliferation (GO:0035988)2.54815360
117apoptotic cell clearance (GO:0043277)2.53998619
118protein localization to cell surface (GO:0034394)2.53548710
119regulation of interleukin-8 secretion (GO:2000482)2.52636518
120vesicle coating (GO:0006901)2.51346757
121* wound healing (GO:0042060)2.51282704
122cell-substrate adherens junction assembly (GO:0007045)2.50593468
123focal adhesion assembly (GO:0048041)2.50593468
124negative regulation of cartilage development (GO:0061037)2.50384908
125negative regulation of anoikis (GO:2000811)2.49615826
126cell-cell junction assembly (GO:0007043)2.49156516
127chemical homeostasis within a tissue (GO:0048875)2.49028747
128renal system process involved in regulation of blood volume (GO:0001977)2.48458423
129regulation of establishment of protein localization to plasma membrane (GO:0090003)2.46892419
130hyaluronan catabolic process (GO:0030214)2.46575071
131basement membrane organization (GO:0071711)2.45742751
132adherens junction organization (GO:0034332)2.45043718
133peptidyl-proline hydroxylation (GO:0019511)2.44328986
134retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.43202078
135blood vessel endothelial cell migration (GO:0043534)2.42414394
136collagen catabolic process (GO:0030574)2.42240943
137heparan sulfate proteoglycan biosynthetic process (GO:0015012)2.42104991
138positive regulation of endothelial cell apoptotic process (GO:2000353)2.42038206
139actin filament depolymerization (GO:0030042)2.41948080
140nucleotide-sugar biosynthetic process (GO:0009226)2.41224395
141regulation of tight junction assembly (GO:2000810)2.41173116
142O-glycan processing (GO:0016266)2.41054169
143positive regulation of pseudopodium assembly (GO:0031274)2.40740088
144regulation of transforming growth factor beta1 production (GO:0032908)2.40535707
145extracellular matrix disassembly (GO:0022617)2.40288907
146negative regulation of cell fate specification (GO:0009996)2.39818981
147mRNA transcription (GO:0009299)2.39816008
148positive regulation of transforming growth factor beta production (GO:0071636)2.39323499
149multicellular organismal macromolecule metabolic process (GO:0044259)2.38680223
150* positive regulation of epithelial cell migration (GO:0010634)2.38673105
151glomerular visceral epithelial cell development (GO:0072015)2.38657272
152iron ion import (GO:0097286)2.38247876

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human8.77663842
2TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse4.45045171
3TRIM28_21343339_ChIP-Seq_HEK293_Human4.24590036
4* SMAD4_19686287_ChIP-ChIP_HaCaT_Human3.83637398
5FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.57098630
6NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.45444625
7RARG_19884340_ChIP-ChIP_MEFs_Mouse3.16263204
8EGR1_19374776_ChIP-ChIP_THP-1_Human2.82411015
9* SMAD2_18955504_ChIP-ChIP_HaCaT_Human2.62955941
10* SMAD3_18955504_ChIP-ChIP_HaCaT_Human2.62955941
11ESR1_21235772_ChIP-Seq_MCF-7_Human2.60499440
12STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.48022195
13STAT6_21828071_ChIP-Seq_BEAS2B_Human2.46724396
14ESR2_21235772_ChIP-Seq_MCF-7_Human2.46184862
15ESR1_20079471_ChIP-ChIP_T-47D_Human2.39481056
16HIF1A_21447827_ChIP-Seq_MCF-7_Human2.39275361
17* FOXO3_23340844_ChIP-Seq_DLD1_Human2.26217638
18CLOCK_20551151_ChIP-Seq_293T_Human2.18826960
19ZNF217_24962896_ChIP-Seq_MCF-7_Human2.13240508
20* PPAR_26484153_Chip-Seq_NCI-H1993_Human2.12613583
21KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human2.12390928
22PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.08569330
23SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse2.06696188
24SOX2_20726797_ChIP-Seq_SW620_Human2.05857731
25CDX2_20551321_ChIP-Seq_CACO-2_Human1.99331714
26CJUN_26792858_Chip-Seq_BT549_Human1.98667060
27* GATA2_21666600_ChIP-Seq_HMVEC_Human1.93491672
28RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.85889257
29SOX2_27498859_Chip-Seq_STOMACH_Mouse1.85702659
30STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.85599783
31SMAD_19615063_ChIP-ChIP_OVARY_Human1.85036619
32* SOX9_24532713_ChIP-Seq_HFSC_Mouse1.69690614
33FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.66618289
34ESR1_15608294_ChIP-ChIP_MCF-7_Human1.63191319
35* GATA6_25053715_ChIP-Seq_YYC3_Human1.61031036
36JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.59213129
37KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.58672891
38ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.57385986
39TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.56680903
40* GATA4_25053715_ChIP-Seq_YYC3_Human1.56024819
41* FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.54976628
42ZNF263_19887448_ChIP-Seq_K562_Human1.53096201
43* ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.52803958
44AR_21909140_ChIP-Seq_LNCAP_Human1.51979583
45EP300_21415370_ChIP-Seq_HL-1_Mouse1.51571878
46STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.48387259
47* BRD4_25478319_ChIP-Seq_HGPS_Human1.47097449
48TCF4_18268006_ChIP-ChIP_LS174T_Human1.45375352
49* ATF3_27146783_Chip-Seq_COLON_Human1.43788882
50RUNX1_27514584_Chip-Seq_MCF-7_Human1.41917553
51ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.41203636
52TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.39718928
53KLF5_25053715_ChIP-Seq_YYC3_Human1.36662712
54CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.33181921
55ELK3_25401928_ChIP-Seq_HUVEC_Human1.29359902
56RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.29329530
57ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.27876576
58CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.27518405
59UBF1/2_26484160_Chip-Seq_HMECs_Human1.26055905
60CDX2_19796622_ChIP-Seq_MESCs_Mouse1.25995176
61AHR_22903824_ChIP-Seq_MCF-7_Human1.25458358
62TP53_22127205_ChIP-Seq_IMR90_Human1.24593667
63JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.24259310
64CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.23933496
65P63_26484246_Chip-Seq_KERATINOCYTES_Human1.23337092
66RACK7_27058665_Chip-Seq_MCF-7_Human1.22738429
67SALL4_18804426_ChIP-ChIP_XEN_Mouse1.22158685
68EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.21454259
69* GATA3_24758297_ChIP-Seq_MCF-7_Human1.18987992
70EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.18600272
71RUNX_20019798_ChIP-Seq_JUKART_Human1.17591242
72NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.16524492
73NRF2_20460467_ChIP-Seq_MEFs_Mouse1.16524492
74RBPJ_22232070_ChIP-Seq_NCS_Mouse1.15802344
75STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.15339641
76TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.11877863
77* ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.11502961
78P300_27058665_Chip-Seq_ZR-75-30cells_Human1.11460827
79NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.09765137
80RXR_22158963_ChIP-Seq_LIVER_Mouse1.09234830
81* FOXM1_26456572_ChIP-Seq_MCF-7_Human1.08121986
82POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.07613367
83TP53_16413492_ChIP-PET_HCT116_Human1.06896814
84MYB_21317192_ChIP-Seq_ERMYB_Mouse1.06457816
85TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.05336958
86PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.04435665
87HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.03675398
88* CTNNB1_20460455_ChIP-Seq_HCT116_Human1.03240108
89* TP63_23658742_ChIP-Seq_EP156T_Human1.02651769
90LXR_22158963_ChIP-Seq_LIVER_Mouse1.01954048
91* NFIB_24661679_ChIP-Seq_LUNG_Mouse1.00462669
92WT1_19549856_ChIP-ChIP_CCG9911_Human0.99174602
93TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.98638850
94TP53_18474530_ChIP-ChIP_U2OS_Human0.96766113
95NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.94502384
96ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.93969233
97VDR_24787735_ChIP-Seq_THP-1_Human0.93514797
98PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.93194483
99KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.92673233
100FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.92472605
101WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.92161481
102GATA2_19941826_ChIP-Seq_K562_Human0.91681062
103SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.89223841
104ARNT_22903824_ChIP-Seq_MCF-7_Human0.88958853
105CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.87676567
106* NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.87335077
107ELK1_22589737_ChIP-Seq_MCF10A_Human0.86083733
108UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.85994185
109NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.85433332
110TP53_23651856_ChIP-Seq_MEFs_Mouse0.84976386
111KDM2B_26808549_Chip-Seq_SUP-B15_Human0.84728793
112* FOXA2_19822575_ChIP-Seq_HepG2_Human0.84725696
113TCF7_22412390_ChIP-Seq_EML_Mouse0.84099121
114TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.82577459
115Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.81775113
116* TBX20_22328084_ChIP-Seq_HEART_Mouse0.80941352
117* TBX20_22080862_ChIP-Seq_HEART_Mouse0.80941352
118ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.78357174
119SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.76421634
120FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.74779122
121PPARA_22158963_ChIP-Seq_LIVER_Mouse0.74674509

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000537_abnormal_urethra_morphology5.00699667
2MP0010234_abnormal_vibrissa_follicle4.44741644
3MP0003705_abnormal_hypodermis_morpholog3.64611070
4MP0000579_abnormal_nail_morphology3.48704002
5MP0010352_gastrointestinal_tract_polyps3.24791146
6MP0003300_gastrointestinal_ulcer3.20487800
7MP0004272_abnormal_basement_membrane3.16082251
8MP0006054_spinal_hemorrhage2.88999154
9MP0003941_abnormal_skin_development2.84836734
10MP0003566_abnormal_cell_adhesion2.55373901
11MP0009780_abnormal_chondrocyte_physiolo2.49853284
12MP0003950_abnormal_plasma_membrane2.49437232
13MP0003045_fibrosis2.39596488
14MP0004264_abnormal_extraembryonic_tissu2.31898008
15MP0010368_abnormal_lymphatic_system2.27968020
16MP0005023_abnormal_wound_healing2.22331408
17MP0005257_abnormal_intraocular_pressure2.20678430
18MP0005409_darkened_coat_color2.15016794
19MP0010678_abnormal_skin_adnexa2.06750179
20MP0009053_abnormal_anal_canal1.99766627
21MP0009384_cardiac_valve_regurgitation1.94828688
22MP0005275_abnormal_skin_tensile1.93534838
23MP0001879_abnormal_lymphatic_vessel1.85735110
24MP0003453_abnormal_keratinocyte_physiol1.76902413
25MP0003091_abnormal_cell_migration1.71039217
26MP0001849_ear_inflammation1.68671246
27MP0010155_abnormal_intestine_physiology1.57470702
28MP0000462_abnormal_digestive_system1.57290231
29MP0000858_altered_metastatic_potential1.54776465
30MP0000678_abnormal_parathyroid_gland1.51157776
31MP0005248_abnormal_Harderian_gland1.46459525
32MP0003828_pulmonary_edema1.42940399
33MP0002282_abnormal_trachea_morphology1.40575711
34MP0003866_abnormal_defecation1.39660410
35MP0002060_abnormal_skin_morphology1.39140181
36MP0001881_abnormal_mammary_gland1.38573449
37MP0005623_abnormal_meninges_morphology1.38309644
38MP0004947_skin_inflammation1.38218659
39MP0003115_abnormal_respiratory_system1.38117628
40MP0002896_abnormal_bone_mineralization1.37286302
41MP0001216_abnormal_epidermal_layer1.36956791
42MP0000383_abnormal_hair_follicle1.35570910
43MP0002877_abnormal_melanocyte_morpholog1.33233766
44MP0003191_abnormal_cellular_cholesterol1.31493863
45MP0002796_impaired_skin_barrier1.29987332
46MP0003315_abnormal_perineum_morphology1.29421833
47MP0008438_abnormal_cutaneous_collagen1.26844566
48MP0002254_reproductive_system_inflammat1.23449953
49MP0005360_urolithiasis1.23019373
50* MP0000627_abnormal_mammary_gland1.22207502
51MP0001299_abnormal_eye_distance/1.21592862
52MP0003448_altered_tumor_morphology1.20250783
53MP0005501_abnormal_skin_physiology1.19196205
54MP0001873_stomach_inflammation1.14526369
55MP0002098_abnormal_vibrissa_morphology1.13742084
56MP0000477_abnormal_intestine_morphology1.11907626
57MP0000013_abnormal_adipose_tissue1.11613932
58MP0005076_abnormal_cell_differentiation1.10885208
59MP0005167_abnormal_blood-brain_barrier1.10063704
60MP0002089_abnormal_postnatal_growth/wei1.09282052
61MP0001853_heart_inflammation1.09236931
62MP0003303_peritoneal_inflammation1.08972211
63MP0003279_aneurysm1.07377572
64MP0004782_abnormal_surfactant_physiolog1.04207935
65MP0005197_abnormal_uvea_morphology1.02716931
66MP0001958_emphysema1.00362644
67MP0002234_abnormal_pharynx_morphology0.98741969
68MP0001663_abnormal_digestive_system0.98379049
69MP0009697_abnormal_copulation0.97845316
70MP0002168_other_aberrant_phenotype0.97311682
71MP0005381_digestive/alimentary_phenotyp0.96666746
72MP0000733_abnormal_muscle_development0.96213726
73MP0000377_abnormal_hair_follicle0.95111394
74MP0010030_abnormal_orbit_morphology0.94523838
75MP0002933_joint_inflammation0.93746033
76MP0000465_gastrointestinal_hemorrhage0.93537756
77MP0004883_abnormal_blood_vessel0.93018760
78MP0000762_abnormal_tongue_morphology0.92994357
79MP0000767_abnormal_smooth_muscle0.92182510
80MP0005165_increased_susceptibility_to0.91908693
81MP0002925_abnormal_cardiovascular_devel0.91852461
82MP0009840_abnormal_foam_cell0.87431238
83MP0003755_abnormal_palate_morphology0.86261169
84MP0005164_abnormal_response_to0.85096030
85MP0000490_abnormal_crypts_of0.84649017
86MP0003868_abnormal_feces_composition0.84385346
87MP0002086_abnormal_extraembryonic_tissu0.84322295
88MP0002177_abnormal_outer_ear0.83405175
89MP0003385_abnormal_body_wall0.83096086
90MP0001533_abnormal_skeleton_physiology0.82746449
91MP0010771_integument_phenotype0.82072761
92MP0000467_abnormal_esophagus_morphology0.81952380
93MP0002295_abnormal_pulmonary_circulatio0.81420411
94MP0009785_altered_susceptibility_to0.81189270
95MP0000249_abnormal_blood_vessel0.80993234
96MP0000003_abnormal_adipose_tissue0.80782151
97MP0003119_abnormal_digestive_system0.80261189
98MP0001191_abnormal_skin_condition0.79523436
99MP0001915_intracranial_hemorrhage0.77936122
100MP0000163_abnormal_cartilage_morphology0.76924266
101MP0005451_abnormal_body_composition0.76621106
102MP0000432_abnormal_head_morphology0.75846551
103MP0001614_abnormal_blood_vessel0.75838442
104MP0004233_abnormal_muscle_weight0.75089904
105MP0002006_tumorigenesis0.75009262
106MP0005408_hypopigmentation0.74951921
107MP0001243_abnormal_dermal_layer0.74837453
108MP0008004_abnormal_stomach_pH0.73390424
109MP0004808_abnormal_hematopoietic_stem0.72907400
110MP0010307_abnormal_tumor_latency0.72633178
111MP0003935_abnormal_craniofacial_develop0.72090155
112MP0000751_myopathy0.72077062
113MP0005508_abnormal_skeleton_morphology0.71224605
114MP0006138_congestive_heart_failure0.70906654
115MP0000534_abnormal_ureter_morphology0.70742227
116MP0005621_abnormal_cell_physiology0.70074081
117MP0009931_abnormal_skin_appearance0.69941269
118MP0002697_abnormal_eye_size0.69404655
119MP0005193_abnormal_anterior_eye0.68963891
120MP0002113_abnormal_skeleton_development0.68549859
121MP0001784_abnormal_fluid_regulation0.67953823
122MP0000647_abnormal_sebaceous_gland0.67001798
123MP0000428_abnormal_craniofacial_morphol0.66849172
124MP0009250_abnormal_appendicular_skeleto0.66346867
125MP0003937_abnormal_limbs/digits/tail_de0.66187623
126MP0009278_abnormal_bone_marrow0.65746909
127MP0005166_decreased_susceptibility_to0.65710734
128MP0002128_abnormal_blood_circulation0.65604456
129MP0000343_altered_response_to0.64961136
130MP0002138_abnormal_hepatobiliary_system0.64636439
131MP0001666_abnormal_nutrient_absorption0.63974366
132MP0000566_synostosis0.63705113
133MP0005390_skeleton_phenotype0.63597616
134MP0001340_abnormal_eyelid_morphology0.62013130

Predicted human phenotypes

RankGene SetZ-score
1Atrophic scars (HP:0001075)5.58326627
2Onycholysis (HP:0001806)5.38300985
3Milia (HP:0001056)5.29243702
4Fragile nails (HP:0001808)4.05952073
5Interstitial pulmonary disease (HP:0006530)3.84122926
6Micronodular cirrhosis (HP:0001413)3.82268735
7Right ventricular cardiomyopathy (HP:0011663)3.61068446
8Focal segmental glomerulosclerosis (HP:0000097)3.54964405
9Aortic aneurysm (HP:0004942)3.54407977
10Abnormality of the nasal septum (HP:0000419)3.42637745
11Thick nail (HP:0001805)3.42484769
12Subacute progressive viral hepatitis (HP:0006572)3.26843063
13Arterial tortuosity (HP:0005116)3.19264985
14Follicular hyperkeratosis (HP:0007502)3.08792739
15Flat acetabular roof (HP:0003180)3.03730810
16Deep venous thrombosis (HP:0002625)2.98827672
17Rectal prolapse (HP:0002035)2.98501358
18Natal tooth (HP:0000695)2.95197465
19Nail dystrophy (HP:0008404)2.93559956
20Vascular tortuosity (HP:0004948)2.91928277
21Fragile skin (HP:0001030)2.90757803
22Glomerulosclerosis (HP:0000096)2.89945669
23Abnormality of nail color (HP:0100643)2.85265810
24Abnormality of carpal bone ossification (HP:0006257)2.83131446
25Aortic dissection (HP:0002647)2.80358435
26Abnormality of the proximal phalanges of the hand (HP:0009834)2.76566623
27Plantar hyperkeratosis (HP:0007556)2.76103140
28Protrusio acetabuli (HP:0003179)2.70421633
29Cerebral aneurysm (HP:0004944)2.68644379
30Ureteral stenosis (HP:0000071)2.68138201
31Ridged nail (HP:0001807)2.59709832
32Palmoplantar hyperkeratosis (HP:0000972)2.59385977
33Esophageal varix (HP:0002040)2.55159208
34Menorrhagia (HP:0000132)2.54900788
35Ureteral obstruction (HP:0006000)2.53873425
36Abnormality of the distal phalanges of the toes (HP:0010182)2.51123767
37Radial bowing (HP:0002986)2.50719800
38Abnormal vertebral ossification (HP:0100569)2.49662767
39Hypoplasia of dental enamel (HP:0006297)2.48579748
40Epiphyseal dysplasia (HP:0002656)2.47046080
41Palmar hyperkeratosis (HP:0010765)2.46407147
42Pustule (HP:0200039)2.45311077
43Selective tooth agenesis (HP:0001592)2.41570709
44Pili torti (HP:0003777)2.41420437
45Abnormal ossification of hand bones (HP:0005921)2.41174413
46Shallow orbits (HP:0000586)2.39713479
47Vertebral compression fractures (HP:0002953)2.37088437
48Wormian bones (HP:0002645)2.36188529
49Spinal rigidity (HP:0003306)2.33224681
50Cervical subluxation (HP:0003308)2.32244665
51Abnormal albumin level (HP:0012116)2.31726514
52Hypoalbuminemia (HP:0003073)2.31726514
53Increased density of long bones (HP:0006392)2.29106440
54Advanced eruption of teeth (HP:0006288)2.29103050
55Bronchomalacia (HP:0002780)2.28253384
56Increased mean platelet volume (HP:0011877)2.27334624
57Ankle contracture (HP:0006466)2.26587298
58Coxa vara (HP:0002812)2.22382764
59Abnormality of the distal phalanx of the thumb (HP:0009617)2.21623811
60Osteolytic defects of the phalanges of the hand (HP:0009771)2.20275777
61Osteolytic defects of the hand bones (HP:0009699)2.20275777
62Mitral stenosis (HP:0001718)2.20177237
63Abnormal hand bone ossification (HP:0010660)2.17690334
64Lymphangioma (HP:0100764)2.15327645
65Deviation of the thumb (HP:0009603)2.14738385
66Pterygium (HP:0001059)2.14455743
67Abnormal blistering of the skin (HP:0008066)2.11601972
68Curly hair (HP:0002212)2.11316580
69Fused cervical vertebrae (HP:0002949)2.10689434
70Abnormality of oral frenula (HP:0000190)2.08802371
71Small epiphyses (HP:0010585)2.08680505
72Abnormality of dentin (HP:0010299)2.07965644
73Abdominal distention (HP:0003270)2.07451162
74Neonatal death (HP:0003811)2.07383037
75Aneurysm (HP:0002617)2.07360266
76Bowing of the arm (HP:0006488)2.06346838
77Bowed forearm bones (HP:0003956)2.06346838
78Trismus (HP:0000211)2.06018591
79Abnormality of the gastric mucosa (HP:0004295)2.05256743
80Abnormal hair laboratory examination (HP:0003328)2.05013527
81Biliary tract neoplasm (HP:0100574)2.03796398
82Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)2.03472560
83Ankyloglossia (HP:0010296)2.02768076
84Short hallux (HP:0010109)2.02440304
85Short nail (HP:0001799)2.02423842
86Premature rupture of membranes (HP:0001788)2.01976773
87Elbow flexion contracture (HP:0002987)1.99896235
88Xerostomia (HP:0000217)1.99423314
89Abnormal platelet volume (HP:0011876)1.98240833
90Spinal cord compression (HP:0002176)1.98174255
91Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.97185321
92Fibular aplasia (HP:0002990)1.96946495
93Bladder diverticulum (HP:0000015)1.96178782
94Aplasia/Hypoplasia of the vertebrae (HP:0008515)1.95763449
95Vertebral hypoplasia (HP:0008417)1.95763449
96Aplasia cutis congenita (HP:0001057)1.94105375
97Synostosis involving the elbow (HP:0003938)1.92490978
98Humeroradial synostosis (HP:0003041)1.92490978
99Abnormal foot bone ossification (HP:0010675)1.91806252
100Abnormality of the Achilles tendon (HP:0005109)1.91788279
101Achilles tendon contracture (HP:0001771)1.91060154
102Tarsal synostosis (HP:0008368)1.90909132
103Glucose intolerance (HP:0000833)1.89048816
104Mildly elevated creatine phosphokinase (HP:0008180)1.88233774
105Esophageal atresia (HP:0002032)1.88213860
106Germ cell neoplasia (HP:0100728)1.87921432
107Vertebral arch anomaly (HP:0008438)1.86910964
108Limited elbow extension (HP:0001377)1.85576597
109Mitral valve prolapse (HP:0001634)1.84650094
110Ulnar bowing (HP:0003031)1.84200492
111Oligodontia (HP:0000677)1.82106928
112Gastrointestinal carcinoma (HP:0002672)1.82065589
113Malignant gastrointestinal tract tumors (HP:0006749)1.82065589
114Spondylolisthesis (HP:0003302)1.80374178
115Distal upper limb amyotrophy (HP:0007149)1.80366769
116Upper limb amyotrophy (HP:0009129)1.80366769
117Aplasia/Hypoplasia of the hallux (HP:0008362)1.80272062
118Hematochezia (HP:0002573)1.78574745
119Short humerus (HP:0005792)1.76566821
120Alopecia of scalp (HP:0002293)1.75681037
121Hypotrichosis (HP:0001006)1.74822707
122Sparse eyelashes (HP:0000653)1.73986799
123Neonatal short-limb short stature (HP:0008921)1.73621490
124Cardiovascular calcification (HP:0011915)1.73468408
125Dilatation of the ascending aorta (HP:0005111)1.72921483
126Broad face (HP:0000283)1.72822303
127Blue sclerae (HP:0000592)1.71967112
128Tibial bowing (HP:0002982)1.71807261
129Syringomyelia (HP:0003396)1.71667570
130Spinal cord lesions (HP:0100561)1.71667570
131Uterine neoplasm (HP:0010784)1.70271948
132Abnormality of the middle phalanges of the toes (HP:0010183)1.69855902
133Woolly hair (HP:0002224)1.69469238
134Neurofibrillary tangles (HP:0002185)1.69353982
135Reduced subcutaneous adipose tissue (HP:0003758)1.68797607
136Abnormality of the acetabulum (HP:0003170)1.68586269
137Hypodontia (HP:0000668)1.67607773
138Abnormality of the common coagulation pathway (HP:0010990)1.67209535
139Joint laxity (HP:0001388)1.66940076
140Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)1.66737329
141Short 1st metacarpal (HP:0010034)1.66737329
142Vascular calcification (HP:0004934)1.65639410
143Absent frontal sinuses (HP:0002688)1.65336638
14411 pairs of ribs (HP:0000878)1.62778778
145Soft skin (HP:0000977)1.62284410
146Protruding ear (HP:0000411)1.60629481
147Popliteal pterygium (HP:0009756)1.60576092
148Blepharitis (HP:0000498)1.59722935
149Overgrowth (HP:0001548)1.59674642
150Tetraparesis (HP:0002273)1.58717941
151Conjugated hyperbilirubinemia (HP:0002908)1.58330462

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA29.57738032
2MST44.35816285
3LATS12.52975501
4EPHB12.48975143
5EPHB22.28971768
6PTK22.26889697
7FRK2.08993397
8FER2.07104086
9PAK42.05705739
10STK102.04787175
11PTK61.99506400
12LATS21.96830901
13RIPK11.92816570
14IRAK31.87339993
15LRRK21.84934259
16MST1R1.79783819
17NEK91.75779893
18MAP3K121.73947720
19TTN1.68808513
20RPS6KB21.63569955
21TGFBR21.57151257
22DMPK1.55765291
23MAP3K21.39156394
24FGFR41.34567414
25NUAK11.30754829
26EPHA31.29723994
27STK31.29710744
28ICK1.28462098
29TGFBR11.28280255
30MET1.27119823
31TRIB31.26492386
32PKN21.24280948
33STK381.18807716
34MAP3K31.18285157
35TESK11.17799575
36PRKG21.17372338
37KDR1.14330168
38STK38L1.13164493
39ARAF1.09238575
40AKT31.06664130
41CDK61.03883204
42TRPM71.00613027
43MAP3K90.98813506
44MAP2K20.98732468
45EIF2AK10.97625833
46LMTK20.92092515
47PDGFRA0.90938275
48CSK0.90277512
49TXK0.89421420
50PAK30.88787033
51BMX0.85640571
52CDK80.85516812
53RPS6KA40.84638967
54DDR20.83883675
55ERBB30.81927535
56FGFR10.81495930
57TIE10.81484640
58FGFR30.76518212
59JAK10.76345722
60MAP2K10.75564679
61PAK20.74755636
62PIM20.73385776
63SMG10.72287544
64MOS0.71082188
65PIK3CA0.68709006
66PDGFRB0.67545911
67WNK40.66383631
68MAP3K80.66220867
69DYRK1B0.65730069
70ERBB20.64324298
71BRSK20.62957964
72MYLK0.61336189
73CHUK0.58459413
74MELK0.57452236
75GSK3A0.57307179
76STK390.57065583
77WNK10.54509560
78SIK10.53951290
79BCR0.53482951
80KSR10.53296580
81NEK10.51964430
82INSR0.51850129
83STK240.51372930
84CDK90.50485381
85PBK0.48406744
86ABL20.47513361
87PTK2B0.46559410
88CSNK1A1L0.46541318
89ROCK10.46085432
90EIF2AK30.46036983
91LIMK10.45640388
92EGFR0.45438227
93MAP3K100.44559903
94PASK0.44327598
95EEF2K0.42937765
96SRC0.42903799
97JAK30.41789939
98MAP3K60.41045918
99ROCK20.39886677
100KSR20.39552769
101ITK0.39443447
102ERN10.38871031
103SCYL20.38629858
104MAP3K70.38298455
105NTRK10.38170361
106MTOR0.37881088
107PRKCI0.37444813
108ABL10.35513360
109MAPKAPK30.35245344
110IGF1R0.32508017
111ERBB40.32185268
112PRKD20.31585105
113CDC42BPA0.31546472
114CDK120.30690414
115RPS6KA20.30400600
116MAPKAPK20.30153411
117ILK0.29231188
118CAMK2B0.28741453
119FGFR20.27861260
120RET0.27084086
121NEK60.26561881
122AURKB0.25248054
123NME20.23743445
124PRKCE0.22622138
125FYN0.22533672
126BMPR1B0.22111228
127SGK30.21766910
128MAP3K10.21557761
129HIPK20.21361593
130FLT30.20439109

Predicted pathways (KEGG)

RankGene SetZ-score
1* ECM-receptor interaction_Homo sapiens_hsa045123.37249769
2Adherens junction_Homo sapiens_hsa045202.84800889
3Bacterial invasion of epithelial cells_Homo sapiens_hsa051002.69276662
4* Small cell lung cancer_Homo sapiens_hsa052222.68256474
5* Focal adhesion_Homo sapiens_hsa045102.56219043
6Pathogenic Escherichia coli infection_Homo sapiens_hsa051302.46865596
7Viral myocarditis_Homo sapiens_hsa054162.45237248
8Leukocyte transendothelial migration_Homo sapiens_hsa046702.33810388
9Complement and coagulation cascades_Homo sapiens_hsa046102.22066975
10Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005122.06928824
11* Proteoglycans in cancer_Homo sapiens_hsa052052.06780752
12* Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054122.03166965
13Tight junction_Homo sapiens_hsa045301.90493353
14Bladder cancer_Homo sapiens_hsa052191.84409803
15Toxoplasmosis_Homo sapiens_hsa051451.81926188
16Amoebiasis_Homo sapiens_hsa051461.80874054
17Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.79306562
18Malaria_Homo sapiens_hsa051441.76769035
19Hippo signaling pathway_Homo sapiens_hsa043901.76217050
20Glycosaminoglycan degradation_Homo sapiens_hsa005311.71325464
21AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.66008399
22Thyroid cancer_Homo sapiens_hsa052161.58397639
23Pancreatic cancer_Homo sapiens_hsa052121.55458961
24Chronic myeloid leukemia_Homo sapiens_hsa052201.54812196
25* Hematopoietic cell lineage_Homo sapiens_hsa046401.54499814
26* Regulation of actin cytoskeleton_Homo sapiens_hsa048101.46589490
27Shigellosis_Homo sapiens_hsa051311.46436201
28MicroRNAs in cancer_Homo sapiens_hsa052061.37751823
29TGF-beta signaling pathway_Homo sapiens_hsa043501.35548972
30Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.31048903
31* PI3K-Akt signaling pathway_Homo sapiens_hsa041511.26852903
32TNF signaling pathway_Homo sapiens_hsa046681.25543285
33Steroid biosynthesis_Homo sapiens_hsa001001.23366331
34Rap1 signaling pathway_Homo sapiens_hsa040151.19977325
35* Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.18874977
36Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.14927683
37Endometrial cancer_Homo sapiens_hsa052131.13434308
38Colorectal cancer_Homo sapiens_hsa052101.12611456
39Renal cell carcinoma_Homo sapiens_hsa052111.12481698
40Mineral absorption_Homo sapiens_hsa049781.11083032
41Sphingolipid metabolism_Homo sapiens_hsa006001.10544729
42* Dilated cardiomyopathy_Homo sapiens_hsa054141.08958095
43Salmonella infection_Homo sapiens_hsa051321.05790865
44* Pathways in cancer_Homo sapiens_hsa052001.05233852
45Prion diseases_Homo sapiens_hsa050201.04833333
46Jak-STAT signaling pathway_Homo sapiens_hsa046301.04762687
47Galactose metabolism_Homo sapiens_hsa000521.04493246
48Allograft rejection_Homo sapiens_hsa053301.03776206
49Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.01885189
50Graft-versus-host disease_Homo sapiens_hsa053321.01880027
51Apoptosis_Homo sapiens_hsa042101.00440936
52* Platelet activation_Homo sapiens_hsa046110.97403984
53Leishmaniasis_Homo sapiens_hsa051400.96397450
54Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.96035859
55Other glycan degradation_Homo sapiens_hsa005110.94581575
56Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.93031004
57Vibrio cholerae infection_Homo sapiens_hsa051100.92538995
58Basal cell carcinoma_Homo sapiens_hsa052170.92047379
59Autoimmune thyroid disease_Homo sapiens_hsa053200.91757531
60Protein digestion and absorption_Homo sapiens_hsa049740.91531378
61Prostate cancer_Homo sapiens_hsa052150.89167706
62Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.88687733
63VEGF signaling pathway_Homo sapiens_hsa043700.88161949
64HTLV-I infection_Homo sapiens_hsa051660.86828367
65Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.85592744
66Axon guidance_Homo sapiens_hsa043600.85182824
67Pertussis_Homo sapiens_hsa051330.84523453
68p53 signaling pathway_Homo sapiens_hsa041150.83981318
69Fatty acid biosynthesis_Homo sapiens_hsa000610.80783856
70Melanoma_Homo sapiens_hsa052180.80769532
71Hepatitis B_Homo sapiens_hsa051610.80267892
72Endocytosis_Homo sapiens_hsa041440.80208391
73Hepatitis C_Homo sapiens_hsa051600.79058641
74Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.78919917
75Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.77733681
76Wnt signaling pathway_Homo sapiens_hsa043100.76672817
77Starch and sucrose metabolism_Homo sapiens_hsa005000.75353825
78Osteoclast differentiation_Homo sapiens_hsa043800.71883082
79Antigen processing and presentation_Homo sapiens_hsa046120.69823023
80Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.69750451
81Dorso-ventral axis formation_Homo sapiens_hsa043200.68785146
82Phenylalanine metabolism_Homo sapiens_hsa003600.67891283
83Glioma_Homo sapiens_hsa052140.66907018
84Viral carcinogenesis_Homo sapiens_hsa052030.66428657
85N-Glycan biosynthesis_Homo sapiens_hsa005100.65716279
86Notch signaling pathway_Homo sapiens_hsa043300.64374931
87Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.64108740
88HIF-1 signaling pathway_Homo sapiens_hsa040660.62877176
89Hedgehog signaling pathway_Homo sapiens_hsa043400.62171776
90Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.61671353
91Circadian rhythm_Homo sapiens_hsa047100.58698623
92ErbB signaling pathway_Homo sapiens_hsa040120.57624238
93Non-small cell lung cancer_Homo sapiens_hsa052230.57597606
94Transcriptional misregulation in cancer_Homo sapiens_hsa052020.57014472
95Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.56751271
96Fructose and mannose metabolism_Homo sapiens_hsa000510.56581964
97Prolactin signaling pathway_Homo sapiens_hsa049170.56462861
98T cell receptor signaling pathway_Homo sapiens_hsa046600.56015823
99Legionellosis_Homo sapiens_hsa051340.54694984
100Acute myeloid leukemia_Homo sapiens_hsa052210.53386484
101Sulfur metabolism_Homo sapiens_hsa009200.51254385
102Inositol phosphate metabolism_Homo sapiens_hsa005620.50765930
103Measles_Homo sapiens_hsa051620.50287447
104Thyroid hormone synthesis_Homo sapiens_hsa049180.50158862
105Fat digestion and absorption_Homo sapiens_hsa049750.50064192
106FoxO signaling pathway_Homo sapiens_hsa040680.49419573
107PPAR signaling pathway_Homo sapiens_hsa033200.47879340
108Lysosome_Homo sapiens_hsa041420.46375955
109Ras signaling pathway_Homo sapiens_hsa040140.45476639
110Melanogenesis_Homo sapiens_hsa049160.45466311
111Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.45385923
112Thyroid hormone signaling pathway_Homo sapiens_hsa049190.45366568
113Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.45110153
114Vitamin digestion and absorption_Homo sapiens_hsa049770.45097440
115Bile secretion_Homo sapiens_hsa049760.45059992
116NOD-like receptor signaling pathway_Homo sapiens_hsa046210.44067546
117Central carbon metabolism in cancer_Homo sapiens_hsa052300.43982346
118African trypanosomiasis_Homo sapiens_hsa051430.42059490
119NF-kappa B signaling pathway_Homo sapiens_hsa040640.41643638
120Renin-angiotensin system_Homo sapiens_hsa046140.41236623
121Toll-like receptor signaling pathway_Homo sapiens_hsa046200.39944181
122Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.39837828
123Insulin resistance_Homo sapiens_hsa049310.38924449
124Estrogen signaling pathway_Homo sapiens_hsa049150.38616272
125Arginine biosynthesis_Homo sapiens_hsa002200.38566748
126Pancreatic secretion_Homo sapiens_hsa049720.38210753
127Insulin signaling pathway_Homo sapiens_hsa049100.38131059
128Neurotrophin signaling pathway_Homo sapiens_hsa047220.38051095
129Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.37632396
130Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.37527740
131Gap junction_Homo sapiens_hsa045400.36155199
132GnRH signaling pathway_Homo sapiens_hsa049120.36013462
133Choline metabolism in cancer_Homo sapiens_hsa052310.34882198
134Sphingolipid signaling pathway_Homo sapiens_hsa040710.33749252
135Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.33469832
136Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.32782315

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