ITGA2B

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the integrin alpha chain family of proteins. The encoded preproprotein is proteolytically processed to generate light and heavy chains that associate through disulfide linkages to form a subunit of the alpha-IIb/beta-3 integrin cell adhesion receptor. This receptor plays a crucial role in the blood coagulation system, by mediating platelet aggregation. Mutations in this gene are associated with platelet-type bleeding disorders, which are characterized by a failure of platelet aggregation, including Glanzmann thrombasthenia. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1neutrophil activation involved in immune response (GO:0002283)7.19507668
2regulation of platelet aggregation (GO:0090330)6.84689756
3definitive hemopoiesis (GO:0060216)6.69729905
4positive regulation of megakaryocyte differentiation (GO:0045654)6.67133928
5thrombin receptor signaling pathway (GO:0070493)6.60540847
6ribosomal small subunit assembly (GO:0000028)6.12743934
7positive regulation of hematopoietic progenitor cell differentiation (GO:1901534)6.11836152
8regulation of platelet activation (GO:0010543)5.91600144
9megakaryocyte development (GO:0035855)5.88431073
10regulation of hypersensitivity (GO:0002883)5.58359576
11lipoxygenase pathway (GO:0019372)5.53059410
12positive regulation of mast cell activation involved in immune response (GO:0033008)5.43882036
13positive regulation of mast cell degranulation (GO:0043306)5.43882036
14* platelet aggregation (GO:0070527)5.42318418
15angiotensin maturation (GO:0002003)4.99187805
16tyrosine phosphorylation of STAT protein (GO:0007260)4.90758584
17negative regulation of homotypic cell-cell adhesion (GO:0034111)4.90318927
18blood coagulation, intrinsic pathway (GO:0007597)4.84490108
19positive regulation of endothelial cell differentiation (GO:0045603)4.81015581
20regulation of integrin activation (GO:0033623)4.79701128
21viral transcription (GO:0019083)4.76377251
22protein neddylation (GO:0045116)4.75791480
23platelet dense granule organization (GO:0060155)4.70549292
24antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.67994695
25antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.67994695
26DNA strand elongation involved in DNA replication (GO:0006271)4.63642028
27positive regulation of B cell differentiation (GO:0045579)4.58735152
28telomere maintenance via semi-conservative replication (GO:0032201)4.57733042
29DNA unwinding involved in DNA replication (GO:0006268)4.55821113
30leukocyte migration involved in inflammatory response (GO:0002523)4.54525501
31translational termination (GO:0006415)4.54145009
32DNA strand elongation (GO:0022616)4.46748762
33positive regulation of mast cell activation (GO:0033005)4.46302868
34neutrophil activation (GO:0042119)4.35674843
35production of molecular mediator involved in inflammatory response (GO:0002532)4.34488117
36positive regulation of myeloid leukocyte mediated immunity (GO:0002888)4.22664283
37positive regulation of granulocyte differentiation (GO:0030854)4.11659554
38translational elongation (GO:0006414)4.11533149
39angiogenesis involved in wound healing (GO:0060055)4.10768534
40negative regulation of platelet activation (GO:0010544)4.07559339
41DNA replication initiation (GO:0006270)4.06851108
42negative regulation of phagocytosis (GO:0050765)4.06641485
43purinergic nucleotide receptor signaling pathway (GO:0035590)4.01513046
44regulation of erythrocyte differentiation (GO:0045646)4.01118912
45SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.99205723
46mast cell activation involved in immune response (GO:0002279)3.97840639
47mast cell degranulation (GO:0043303)3.97840639
48embryonic hemopoiesis (GO:0035162)3.97417350
49actin nucleation (GO:0045010)3.95629669
50negative regulation of thymocyte apoptotic process (GO:0070244)3.94626859
51adenosine receptor signaling pathway (GO:0001973)3.93499131
52mast cell activation (GO:0045576)3.90700254
53cotranslational protein targeting to membrane (GO:0006613)3.89733354
54protein targeting to ER (GO:0045047)3.88756551
55* homotypic cell-cell adhesion (GO:0034109)3.88719715
56secretory granule organization (GO:0033363)3.85447762
57regulation of mast cell degranulation (GO:0043304)3.80750024
58telomere maintenance via recombination (GO:0000722)3.78922894
59antigen processing and presentation of endogenous antigen (GO:0019883)3.78465982
60granulocyte activation (GO:0036230)3.78424378
61negative regulation of erythrocyte differentiation (GO:0045647)3.77307462
62regulation of homotypic cell-cell adhesion (GO:0034110)3.76026396
63establishment of protein localization to endoplasmic reticulum (GO:0072599)3.71906820
64leukocyte degranulation (GO:0043299)3.68504701
65nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.64715911
66ribosomal small subunit biogenesis (GO:0042274)3.63453038
67protein localization to endoplasmic reticulum (GO:0070972)3.63417979
68positive regulation of erythrocyte differentiation (GO:0045648)3.60717043
69mitotic recombination (GO:0006312)3.59328296
70viral life cycle (GO:0019058)3.57594339
71G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)3.57512678
72leukotriene biosynthetic process (GO:0019370)3.57058798
73erythrocyte maturation (GO:0043249)3.54635079
74myeloid cell development (GO:0061515)3.54040429
75negative regulation of norepinephrine secretion (GO:0010700)3.53044782
76regulation of inositol phosphate biosynthetic process (GO:0010919)3.52967525
77regulation of mast cell activation involved in immune response (GO:0033006)3.52941270
78pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.52885999
79regulation of megakaryocyte differentiation (GO:0045652)3.52602364
80regulation of acute inflammatory response to antigenic stimulus (GO:0002864)3.51811357
81cellular protein complex disassembly (GO:0043624)3.49535457
82negative regulation of hematopoietic progenitor cell differentiation (GO:1901533)3.49248051
83germ cell migration (GO:0008354)3.48615775
84positive regulation of leukocyte degranulation (GO:0043302)3.47573828
85granulocyte differentiation (GO:0030851)3.46234792
86positive regulation of gamma-delta T cell activation (GO:0046645)3.44027046
87maturation of SSU-rRNA (GO:0030490)3.43575659
88T cell homeostasis (GO:0043029)3.42691947
89endothelium development (GO:0003158)3.41425749
90* platelet activation (GO:0030168)3.39479516
91superoxide anion generation (GO:0042554)3.38303512
92regulation of integrin-mediated signaling pathway (GO:2001044)3.38238817
93histamine transport (GO:0051608)3.36829778
94regulation of mast cell activation (GO:0033003)3.33708024
95regulation of MHC class II biosynthetic process (GO:0045346)3.32574563
96oxygen transport (GO:0015671)3.32099949
97purinergic receptor signaling pathway (GO:0035587)3.28326416
98pyrimidine deoxyribonucleotide metabolic process (GO:0009219)3.27697806
99polyamine biosynthetic process (GO:0006596)3.27222260
100Arp2/3 complex-mediated actin nucleation (GO:0034314)3.26469294
101protoporphyrinogen IX metabolic process (GO:0046501)3.23032030
102translational initiation (GO:0006413)3.22203529
103antigen processing and presentation via MHC class Ib (GO:0002475)3.20956209
104monoamine transport (GO:0015844)3.20138169
105negative regulation of stress fiber assembly (GO:0051497)3.18877951
106telomere maintenance via telomere lengthening (GO:0010833)3.17337006
107toxin transport (GO:1901998)3.16911342
108regulation of endothelial cell differentiation (GO:0045601)3.16721707
109fusion of sperm to egg plasma membrane (GO:0007342)3.16123586
110negative regulation of T cell apoptotic process (GO:0070233)3.15034361
111protein complex disassembly (GO:0043241)3.14919992
112negative regulation of heart rate (GO:0010459)3.14209215
113positive regulation of hemostasis (GO:1900048)3.13193448
114positive regulation of blood coagulation (GO:0030194)3.13193448
115protein localization to kinetochore (GO:0034501)3.11452964
116* platelet degranulation (GO:0002576)3.10756496
117regulation of mitochondrial depolarization (GO:0051900)3.09926787
118triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.09491242
119positive regulation of macrophage differentiation (GO:0045651)3.07928265
120regulation of leukocyte degranulation (GO:0043300)3.07596202
121nucleotide-excision repair, DNA gap filling (GO:0006297)3.07051872
122antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.05450211
123negative regulation of macrophage derived foam cell differentiation (GO:0010745)3.03298628
124cytokine production involved in immune response (GO:0002367)3.03016591
125pyrimidine nucleotide catabolic process (GO:0006244)3.00603365
126deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.94700440
127DNA topological change (GO:0006265)2.93137668
128negative regulation of RNA splicing (GO:0033119)2.92293592
129autophagic vacuole fusion (GO:0000046)2.90308783
130macromolecular complex disassembly (GO:0032984)2.90196490
131platelet formation (GO:0030220)2.89371436
132heparin metabolic process (GO:0030202)2.89160260
133heparin biosynthetic process (GO:0030210)2.89160260
134regulation of gamma-delta T cell differentiation (GO:0045586)2.87407828
135long-chain fatty acid biosynthetic process (GO:0042759)2.87397105
136positive regulation by symbiont of host defense response (GO:0052509)2.87286534
137modulation by symbiont of host defense response (GO:0052031)2.87286534
138modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.87286534
139modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.87286534
140positive regulation by organism of defense response of other organism involved in symbiotic interact2.87286534
141modulation by symbiont of host immune response (GO:0052553)2.87286534
142positive regulation of mitochondrial calcium ion concentration (GO:0051561)2.85763255
143DNA deamination (GO:0045006)2.85665998
144regulation of myeloid leukocyte mediated immunity (GO:0002886)2.84037185
145myeloid cell activation involved in immune response (GO:0002275)2.83575766
146cyclooxygenase pathway (GO:0019371)2.83099133
147response to host immune response (GO:0052572)2.83065938
148response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.83065938
149regulation of DNA endoreduplication (GO:0032875)2.81805454
150protein localization to chromosome, centromeric region (GO:0071459)2.81109949
151regulation of gamma-delta T cell activation (GO:0046643)2.79739578
152regulation of Golgi to plasma membrane protein transport (GO:0042996)2.79521876
153lymphoid progenitor cell differentiation (GO:0002320)2.78929298
154negative regulation of calcium ion transport into cytosol (GO:0010523)2.78011553
155pyrimidine nucleoside catabolic process (GO:0046135)2.77703237
156positive regulation of tyrosine phosphorylation of Stat1 protein (GO:0042511)2.77318426
157nuclear-transcribed mRNA catabolic process (GO:0000956)2.77093459
158translesion synthesis (GO:0019985)2.76519845
159regulation of granulocyte differentiation (GO:0030852)2.76037025
160positive regulation of cAMP-mediated signaling (GO:0043950)2.75635865
161positive regulation of coagulation (GO:0050820)2.75195707
162positive regulation of Rho protein signal transduction (GO:0035025)2.73791748
163erythrocyte differentiation (GO:0030218)2.71821994
164regulation of B cell differentiation (GO:0045577)2.71548627
165negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.71286899
1663-UTR-mediated mRNA stabilization (GO:0070935)2.69645344
167cellular response to thyroid hormone stimulus (GO:0097067)2.66727642
168positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.65662455
169mRNA catabolic process (GO:0006402)2.64019191
170erythrocyte development (GO:0048821)2.58046887
171regulation of necroptotic process (GO:0060544)2.57996223
172positive regulation of inflammatory response to antigenic stimulus (GO:0002863)2.57594199
173RNA catabolic process (GO:0006401)2.56580902

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human8.76866399
2* SCL_19346495_ChIP-Seq_HPC-7_Human4.46887214
3SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human4.37118380
4BP1_19119308_ChIP-ChIP_Hs578T_Human3.89456614
5EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.73783775
6GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human3.44183489
7* MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.07768593
8FOXM1_23109430_ChIP-Seq_U2OS_Human2.96942950
9E2F4_17652178_ChIP-ChIP_JURKAT_Human2.91286228
10RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.89305213
11EGR1_19374776_ChIP-ChIP_THP-1_Human2.88085939
12* GATA2_19941826_ChIP-Seq_K562_Human2.84407656
13TAL1_20887958_ChIP-Seq_HPC-7_Mouse2.75867705
14* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.66554689
15MYC_18555785_ChIP-Seq_MESCs_Mouse2.58255847
16GATA1_22025678_ChIP-Seq_K562_Human2.50178540
17MYC_22102868_ChIP-Seq_BL_Human2.49197047
18VDR_21846776_ChIP-Seq_THP-1_Human2.40978994
19ELF1_17652178_ChIP-ChIP_JURKAT_Human2.34778852
20MYB_21317192_ChIP-Seq_ERMYB_Mouse2.32702226
21SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.26741749
22FLI1_20887958_ChIP-Seq_HPC-7_Mouse2.17216179
23FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.17124140
24GATA2_21666600_ChIP-Seq_HMVEC_Human2.07185606
25HOXB4_20404135_ChIP-ChIP_EML_Mouse2.05308243
26* TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse2.03933173
27* GATA1_22383799_ChIP-Seq_G1ME_Mouse2.01311154
28* RUNX1_22412390_ChIP-Seq_EML_Mouse1.96691895
29LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.95821075
30LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.95206937
31SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.94462518
32* GATA1_19941827_ChIP-Seq_MEL_Mouse1.86876379
33* SPI1_23547873_ChIP-Seq_NB4_Human1.85714941
34FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.84463704
35IRF8_22096565_ChIP-ChIP_GC-B_Human1.84335897
36IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.83961672
37MYC_18358816_ChIP-ChIP_MESCs_Mouse1.77040481
38ERG_20887958_ChIP-Seq_HPC-7_Mouse1.73390201
39EST1_17652178_ChIP-ChIP_JURKAT_Human1.71637389
40VDR_24763502_ChIP-Seq_THP-1_Human1.71005224
41XRN2_22483619_ChIP-Seq_HELA_Human1.69684958
42SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.68925592
43* TCF7_22412390_ChIP-Seq_EML_Mouse1.68271475
44E2F1_21310950_ChIP-Seq_MCF-7_Human1.67522527
45MYC_19079543_ChIP-ChIP_MESCs_Mouse1.67498897
46GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.66806631
47Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.66781260
48IKZF1_21737484_ChIP-ChIP_HCT116_Human1.66648150
49ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.65984020
50STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.65934663
51PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.62762816
52* GATA2_22383799_ChIP-Seq_G1ME_Mouse1.62573132
53MAF_26560356_Chip-Seq_TH1_Human1.62466582
54NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.60346783
55CIITA_25753668_ChIP-Seq_RAJI_Human1.55803740
56MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.55313141
57MYC_19030024_ChIP-ChIP_MESCs_Mouse1.53503018
58GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.52945771
59E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.52505291
60FOXP3_21729870_ChIP-Seq_TREG_Human1.51870387
61UTX_26944678_Chip-Seq_JUKART_Human1.49861274
62VDR_23849224_ChIP-Seq_CD4+_Human1.47490053
63MYB_26560356_Chip-Seq_TH2_Human1.47346606
64GATA1_19941827_ChIP-Seq_MEL86_Mouse1.46662288
65MYB_26560356_Chip-Seq_TH1_Human1.44987171
66SPI1_20517297_ChIP-Seq_HL60_Human1.44278043
67HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.44045901
68ETS1_20019798_ChIP-Seq_JURKAT_Human1.43781647
69* BRD4_27068464_Chip-Seq_AML-cells_Mouse1.40127214
70ELK4_26923725_Chip-Seq_MESODERM_Mouse1.39964139
71STAT4_19710469_ChIP-ChIP_TH1__Mouse1.39717713
72GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.38715689
73GATA3_27048872_Chip-Seq_THYMUS_Human1.35789088
74KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse1.32702984
75SRY_22984422_ChIP-ChIP_TESTIS_Rat1.31182323
76GABP_17652178_ChIP-ChIP_JURKAT_Human1.29701123
77NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.28769549
78FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.28648391
79BCL6_27268052_Chip-Seq_Bcells_Human1.25481588
80HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.25165985
81AR_21909140_ChIP-Seq_LNCAP_Human1.24813679
82GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.23350214
83NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.22657367
84HTT_18923047_ChIP-ChIP_STHdh_Human1.22348144
85MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.21737570
86SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.21262769
87NELFA_20434984_ChIP-Seq_ESCs_Mouse1.19686515
88EZH2_22144423_ChIP-Seq_EOC_Human1.16722749
89RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.15854503
90FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.14088689
91CREB1_15753290_ChIP-ChIP_HEK293T_Human1.13689113
92NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.12208471
93PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.12119448
94TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.11807722
95BCOR_27268052_Chip-Seq_Bcells_Human1.11767790
96KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.11753652
97GATA1_19941826_ChIP-Seq_K562_Human1.11216370
98NOTCH1_21737748_ChIP-Seq_TLL_Human1.10015390
99KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.09959544
100TTF2_22483619_ChIP-Seq_HELA_Human1.09877217
101JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.09684192
102* SRF_21415370_ChIP-Seq_HL-1_Mouse1.09308337
103STAT1_20625510_ChIP-Seq_HELA_Human1.09223549
104ELK1_19687146_ChIP-ChIP_HELA_Human1.09185886
105CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.08059997
106SPI1_23127762_ChIP-Seq_K562_Human1.07563594
107PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.07185218
108PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.06814126
109ELF1_20517297_ChIP-Seq_JURKAT_Human1.06078932
110DCP1A_22483619_ChIP-Seq_HELA_Human1.05738032
111P300_27268052_Chip-Seq_Bcells_Human1.05165361
112YY1_22570637_ChIP-Seq_MALME-3M_Human1.03873861
113GATA3_26560356_Chip-Seq_TH2_Human1.03800356
114GABP_19822575_ChIP-Seq_HepG2_Human1.03768497
115* ETS1_22383799_ChIP-Seq_G1ME_Mouse1.03649783
116E2F1_18555785_ChIP-Seq_MESCs_Mouse1.02668937
117THAP11_20581084_ChIP-Seq_MESCs_Mouse1.02270754
118CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.01852139
119CTCF_27219007_Chip-Seq_ERYTHROID_Human1.00571908
120ZFX_18555785_ChIP-Seq_MESCs_Mouse1.00008855
121CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.99279768
122SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.99112850
123ELK3_25401928_ChIP-Seq_HUVEC_Human0.98723195
124STAT3_20064451_ChIP-Seq_CD4+T_Mouse0.98236842
125MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.97525073
126IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.97058478
127VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.96970018
128FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse0.96008811
129HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.95601158
130CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.95321806
131NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.94543867
132CHD1_19587682_ChIP-ChIP_MESCs_Mouse0.94010450
133MAF_26560356_Chip-Seq_TH2_Human0.93881321
134PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.93585546
135CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.92069805
136CTCF_21964334_ChIP-Seq_BJAB-B_Human0.91475385
137MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse0.90746932
138STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.89458421
139IRF8_21731497_ChIP-ChIP_J774_Mouse0.89280421
140IRF8_27001747_Chip-Seq_BMDM_Mouse0.89218349
141RUNX_20019798_ChIP-Seq_JUKART_Human0.88112018
142CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.88059033
143* NCOR1_26117541_ChIP-Seq_K562_Human0.87788921
144CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.82231992
145NANOG_20526341_ChIP-Seq_ESCs_Human0.81913426
146CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.81667187
147CTCF_21964334_Chip-Seq_Bcells_Human0.78298574
148* PU_27001747_Chip-Seq_BMDM_Mouse0.75205001

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008004_abnormal_stomach_pH4.58932240
2MP0002396_abnormal_hematopoietic_system4.40041512
3MP0004147_increased_porphyrin_level3.80234854
4* MP0005464_abnormal_platelet_physiology3.61316541
5MP0005397_hematopoietic_system_phenotyp3.46923706
6MP0001545_abnormal_hematopoietic_system3.46923706
7MP0002877_abnormal_melanocyte_morpholog3.24710067
8* MP0004808_abnormal_hematopoietic_stem3.03166903
9MP0005083_abnormal_biliary_tract2.95754584
10MP0005174_abnormal_tail_pigmentation2.92729910
11* MP0000465_gastrointestinal_hemorrhage2.65208461
12MP0010094_abnormal_chromosome_stability2.45685656
13MP0009278_abnormal_bone_marrow2.45582779
14MP0003656_abnormal_erythrocyte_physiolo2.41718992
15* MP0002398_abnormal_bone_marrow2.38726530
16MP0008057_abnormal_DNA_replication2.34587636
17MP0003111_abnormal_nucleus_morphology2.28295312
18MP0005075_abnormal_melanosome_morpholog2.23784511
19MP0003693_abnormal_embryo_hatching2.18712270
20MP0005671_abnormal_response_to2.14462228
21MP0000490_abnormal_crypts_of2.12069159
22MP0001835_abnormal_antigen_presentation2.00665621
23MP0003436_decreased_susceptibility_to1.95503431
24* MP0002722_abnormal_immune_system1.93602603
25MP0003300_gastrointestinal_ulcer1.90746721
26MP0005167_abnormal_blood-brain_barrier1.86153301
27MP0005025_abnormal_response_to1.83337573
28MP0002420_abnormal_adaptive_immunity1.82129731
29MP0001851_eye_inflammation1.79476879
30MP0001819_abnormal_immune_cell1.79447244
31* MP0000689_abnormal_spleen_morphology1.79170282
32* MP0002429_abnormal_blood_cell1.78502650
33MP0003077_abnormal_cell_cycle1.75747828
34MP0001800_abnormal_humoral_immune1.75273235
35MP0009333_abnormal_splenocyte_physiolog1.74014298
36MP0002419_abnormal_innate_immunity1.72234680
37MP0000716_abnormal_immune_system1.71863796
38MP0002148_abnormal_hypersensitivity_rea1.71591594
39MP0005000_abnormal_immune_tolerance1.69273287
40MP0006054_spinal_hemorrhage1.67266316
41MP0003724_increased_susceptibility_to1.65571415
42MP0002723_abnormal_immune_serum1.64846960
43MP0001853_heart_inflammation1.64471762
44MP0002095_abnormal_skin_pigmentation1.64400063
45MP0003303_peritoneal_inflammation1.62734169
46MP0010155_abnormal_intestine_physiology1.59594623
47MP0002452_abnormal_antigen_presenting1.57303347
48MP0000343_altered_response_to1.56893442
49MP0002736_abnormal_nociception_after1.54552299
50MP0009785_altered_susceptibility_to1.50585198
51MP0002405_respiratory_system_inflammati1.49415863
52MP0003763_abnormal_thymus_physiology1.47835016
53MP0000230_abnormal_systemic_arterial1.47655647
54MP0005410_abnormal_fertilization1.47428568
55MP0005084_abnormal_gallbladder_morpholo1.46841123
56MP0000703_abnormal_thymus_morphology1.45179804
57MP0004510_myositis1.43993366
58MP0002733_abnormal_thermal_nociception1.43463198
59MP0008007_abnormal_cellular_replicative1.43427654
60MP0001790_abnormal_immune_system1.42554254
61MP0005387_immune_system_phenotype1.42554254
62MP0003866_abnormal_defecation1.41493936
63MP0001986_abnormal_taste_sensitivity1.39301290
64MP0010307_abnormal_tumor_latency1.37652237
65MP0001188_hyperpigmentation1.37516821
66MP0001873_stomach_inflammation1.35159317
67MP0005646_abnormal_pituitary_gland1.34930241
68MP0005058_abnormal_lysosome_morphology1.33302432
69MP0000685_abnormal_immune_system1.32186525
70MP0010352_gastrointestinal_tract_polyps1.30379420
71MP0008872_abnormal_physiological_respon1.26538982
72MP0004957_abnormal_blastocyst_morpholog1.25618153
73MP0003638_abnormal_response/metabolism_1.25218146
74MP0002019_abnormal_tumor_incidence1.22732919
75MP0003943_abnormal_hepatobiliary_system1.18503716
76MP0001845_abnormal_inflammatory_respons1.16471191
77MP0009765_abnormal_xenobiotic_induced1.16084678
78MP0002132_abnormal_respiratory_system1.14790800
79MP0001968_abnormal_touch/_nociception1.13409335
80MP0000015_abnormal_ear_pigmentation1.12880993
81MP0002166_altered_tumor_susceptibility1.12338898
82MP0008469_abnormal_protein_level1.12283856
83MP0003191_abnormal_cellular_cholesterol1.11950122
84MP0000313_abnormal_cell_death1.10782283
85MP0008874_decreased_physiological_sensi1.08803077
86MP0004084_abnormal_cardiac_muscle1.05932374
87MP0003718_maternal_effect0.97950006
88MP0008770_decreased_survivor_rate0.97933969
89MP0008058_abnormal_DNA_repair0.96678710
90MP0005535_abnormal_body_temperature0.95573830
91MP0001533_abnormal_skeleton_physiology0.92386890
92MP0004130_abnormal_muscle_cell0.90648897
93MP0008873_increased_physiological_sensi0.90070971
94MP0008260_abnormal_autophagy0.89927357
95MP0009763_increased_sensitivity_to0.88414492
96MP0006035_abnormal_mitochondrial_morpho0.87797831
97* MP0009642_abnormal_blood_homeostasis0.87324614
98MP0001915_intracranial_hemorrhage0.86522690
99MP0002006_tumorigenesis0.86102262
100MP0000858_altered_metastatic_potential0.85278044
101MP0002735_abnormal_chemical_nociception0.85088386
102MP0005636_abnormal_mineral_homeostasis0.82172534
103MP0005381_digestive/alimentary_phenotyp0.82152739
104MP0001970_abnormal_pain_threshold0.81831774
105MP0009764_decreased_sensitivity_to0.81675543
106MP0001663_abnormal_digestive_system0.80168810
107MP0010368_abnormal_lymphatic_system0.79433307
108MP0002938_white_spotting0.77736324
109MP0003806_abnormal_nucleotide_metabolis0.77489077
110MP0008932_abnormal_embryonic_tissue0.77336116
111MP0009379_abnormal_foot_pigmentation0.77229683
112MP0000598_abnormal_liver_morphology0.76803818
113MP0003828_pulmonary_edema0.76316701
114MP0000350_abnormal_cell_proliferation0.73524612
115MP0001765_abnormal_ion_homeostasis0.72877184
116MP0004036_abnormal_muscle_relaxation0.72261690
117MP0003172_abnormal_lysosome_physiology0.71930373
118MP0010329_abnormal_lipoprotein_level0.70500018
119MP0000249_abnormal_blood_vessel0.69993407
120MP0006036_abnormal_mitochondrial_physio0.69944407
121MP0009840_abnormal_foam_cell0.69807711
122MP0000358_abnormal_cell_content/0.68822327
123MP0008775_abnormal_heart_ventricle0.68383210
124MP0006082_CNS_inflammation0.68108457
125MP0004947_skin_inflammation0.67076222
126MP0000477_abnormal_intestine_morphology0.65881394
127MP0002118_abnormal_lipid_homeostasis0.63636711
128MP0003186_abnormal_redox_activity0.62995340
129* MP0002086_abnormal_extraembryonic_tissu0.62981339
130MP0005647_abnormal_sex_gland0.62156561
131MP0003075_altered_response_to0.62012161
132MP0003183_abnormal_peptide_metabolism0.61283485
133MP0002080_prenatal_lethality0.60893304
134MP0001664_abnormal_digestion0.60855314
135MP0009931_abnormal_skin_appearance0.59773461
136MP0006276_abnormal_autonomic_nervous0.58597149
137MP0003879_abnormal_hair_cell0.58083426
138MP0005165_increased_susceptibility_to0.57423140

Predicted human phenotypes

RankGene SetZ-score
1* Prolonged bleeding time (HP:0003010)7.58529912
2* Petechiae (HP:0000967)7.21906904
3Abnormality of the heme biosynthetic pathway (HP:0010472)5.55433699
4Abnormal number of erythroid precursors (HP:0012131)5.50170270
5* Abnormal platelet volume (HP:0011876)5.45611428
6Abnormality of cells of the erythroid lineage (HP:0012130)5.41088973
7* Purpura (HP:0000979)5.33067928
8Chronic otitis media (HP:0000389)5.16044444
9* Increased mean platelet volume (HP:0011877)5.06707377
10Aplastic anemia (HP:0001915)4.93195009
11* Menorrhagia (HP:0000132)4.83850494
12* Epistaxis (HP:0000421)4.70830900
13* Impaired platelet aggregation (HP:0003540)4.52453763
14* Abnormal platelet function (HP:0011869)4.52453763
15Thrombocytosis (HP:0001894)4.17998011
16Hyperthyroidism (HP:0000836)4.11221682
17Poikilocytosis (HP:0004447)3.92734446
18Hyperlipoproteinemia (HP:0010980)3.87555225
19IgM deficiency (HP:0002850)3.78462182
20Chronic obstructive pulmonary disease (HP:0006510)3.76667261
21Obstructive lung disease (HP:0006536)3.76667261
22Reticulocytopenia (HP:0001896)3.69729193
23Pallor (HP:0000980)3.56079919
24Stomatitis (HP:0010280)3.45082720
25* Gingival bleeding (HP:0000225)3.29694636
26Recurrent viral infections (HP:0004429)3.19480475
27Cellulitis (HP:0100658)3.17689888
28Papilledema (HP:0001085)3.15600189
29Acute myeloid leukemia (HP:0004808)3.11140088
30Acanthocytosis (HP:0001927)3.02700842
31Panhypogammaglobulinemia (HP:0003139)2.96379026
32Abnormality of macrophages (HP:0004311)2.94774079
33Abnormal delayed hypersensitivity skin test (HP:0002963)2.91389979
34Abnormal pupillary function (HP:0007686)2.91219841
35Abnormality of transition element cation homeostasis (HP:0011030)2.89694407
36Myelodysplasia (HP:0002863)2.87481938
37Recurrent abscess formation (HP:0002722)2.86929988
38Hepatosplenomegaly (HP:0001433)2.84554081
39Nasal polyposis (HP:0100582)2.83602350
40Abnormality of the nasal mucosa (HP:0000433)2.80729384
41Esophageal neoplasm (HP:0100751)2.80254079
42Neoplasm of head and neck (HP:0012288)2.80254079
43Paralysis (HP:0003470)2.77387927
44Macrocytic anemia (HP:0001972)2.72566191
45Abnormality of reticulocytes (HP:0004312)2.71400481
46Abnormality of lateral ventricle (HP:0030047)2.71243681
47Recurrent bacterial skin infections (HP:0005406)2.70921866
48Episodic fever (HP:0001954)2.67206664
49Conjunctival telangiectasia (HP:0000524)2.64889272
50Seborrheic dermatitis (HP:0001051)2.60856388
51Recurrent fungal infections (HP:0002841)2.59075904
52Hypochromic anemia (HP:0001931)2.56592206
53Abnormality of the common coagulation pathway (HP:0010990)2.52730255
54Increased IgM level (HP:0003496)2.51368641
55Dyschromatopsia (HP:0007641)2.50794173
56Hypertensive crisis (HP:0100735)2.48914057
57Acute lymphatic leukemia (HP:0006721)2.47939746
58Abnormality of the prostate (HP:0008775)2.47677935
59Abnormality of the vasculature of the conjunctiva (HP:0008054)2.47201918
60Muscle fiber atrophy (HP:0100295)2.44640137
61Patchy hypopigmentation of hair (HP:0011365)2.44099421
62Truncus arteriosus (HP:0001660)2.39854252
6311 pairs of ribs (HP:0000878)2.34349862
64Abnormality of T cell physiology (HP:0011840)2.33883913
65Eczematoid dermatitis (HP:0000976)2.33619063
66Microcytic anemia (HP:0001935)2.29981175
67Arterial thrombosis (HP:0004420)2.29635561
68White forelock (HP:0002211)2.28393719
69Asplenia (HP:0001746)2.23085904
70Hyperacusis (HP:0010780)2.21579602
71Reduced antithrombin III activity (HP:0001976)2.20663121
72Cutaneous melanoma (HP:0012056)2.19652525
73Albinism (HP:0001022)2.19575685
74Type 2 muscle fiber atrophy (HP:0003554)2.17367178
75Reticulocytosis (HP:0001923)2.16090581
76Tinnitus (HP:0000360)2.14433096
77Gastrointestinal inflammation (HP:0004386)2.12854898
78Inflammation of the large intestine (HP:0002037)2.10606926
79Autoimmune hemolytic anemia (HP:0001890)2.10526366
80Heterochromia iridis (HP:0001100)2.10521248
81Joint swelling (HP:0001386)2.09713277
82Spontaneous hematomas (HP:0007420)2.07284956
83Chest pain (HP:0100749)2.06080913
84Lymphoma (HP:0002665)2.04606604
85Encephalitis (HP:0002383)2.03358951
86Recurrent bronchitis (HP:0002837)2.02636400
87* Bruising susceptibility (HP:0000978)2.02303017
88Abnormality of the fingertips (HP:0001211)2.00256290
89Bone marrow hypocellularity (HP:0005528)1.98656269
90Amaurosis fugax (HP:0100576)1.98364572
91Vertigo (HP:0002321)1.98359770
92Slender long bone (HP:0003100)1.97890079
93Increased serum ferritin (HP:0003281)1.97530796
94Birth length less than 3rd percentile (HP:0003561)1.97162893
95Granulocytopenia (HP:0001913)1.96765194
96Urticaria (HP:0001025)1.96681392
97Increased density of long bones (HP:0006392)1.95991180
98Type I transferrin isoform profile (HP:0003642)1.93947932
99Pancytopenia (HP:0001876)1.92369381
100Aplasia/Hypoplasia of the spleen (HP:0010451)1.92197984
101Recurrent skin infections (HP:0001581)1.89819372
102Abnormal large intestine physiology (HP:0012700)1.86425386
103Interstitial pulmonary disease (HP:0006530)1.85292207
104Elevated erythrocyte sedimentation rate (HP:0003565)1.85051633
105Neutropenia (HP:0001875)1.82399536
106Viral hepatitis (HP:0006562)1.81152668
107Meningitis (HP:0001287)1.81031893
108Hyperbilirubinemia (HP:0002904)1.79611668
109Thrombophlebitis (HP:0004418)1.79270374
110Polycythemia (HP:0001901)1.78698774
111Broad palm (HP:0001169)1.78132691
112Myositis (HP:0100614)1.77739616
113Hypochromic microcytic anemia (HP:0004840)1.76170507
114Leukocytosis (HP:0001974)1.76074249
115Spontaneous abortion (HP:0005268)1.75997473
116Erythema (HP:0010783)1.75302595
117Increased IgE level (HP:0003212)1.74755954
118Agammaglobulinemia (HP:0004432)1.73356703
119High pitched voice (HP:0001620)1.73207540
120Hypoparathyroidism (HP:0000829)1.72696861
121Abnormality of T cells (HP:0002843)1.71645192
122Ventricular fibrillation (HP:0001663)1.71141119
123Easy fatigability (HP:0003388)1.70457550
124Gastrointestinal stroma tumor (HP:0100723)1.70124970
125Chronic mucocutaneous candidiasis (HP:0002728)1.70122890
126Recurrent cutaneous fungal infections (HP:0011370)1.70122890
127Hypoplasia of the thymus (HP:0000778)1.70087780
128Migraine (HP:0002076)1.69877875
129Aplasia/Hypoplasia of the thymus (HP:0010515)1.69445913
130Visual hallucinations (HP:0002367)1.68956903
131Short middle phalanx of the 5th finger (HP:0004220)1.67554563
132Thoracic kyphosis (HP:0002942)1.66979172
133Generalized aminoaciduria (HP:0002909)1.66425221
134Severe visual impairment (HP:0001141)1.65846568
135Colitis (HP:0002583)1.65703946
136Upper limb muscle weakness (HP:0003484)1.63957138
137Atelectasis (HP:0100750)1.63677595
138Abnormality of iron homeostasis (HP:0011031)1.62885641
139Bowel incontinence (HP:0002607)1.58887843
140Joint hemorrhage (HP:0005261)1.58120319
141Decreased central vision (HP:0007663)1.55989151
142Abnormal hemoglobin (HP:0011902)1.55706448
143Splenomegaly (HP:0001744)1.52598606
144Dysautonomia (HP:0002459)1.51766935
145Exertional dyspnea (HP:0002875)1.50152075
146Nausea (HP:0002018)1.49134773
147Cerebral palsy (HP:0100021)1.49020025
148Male infertility (HP:0003251)1.44469648
149Hypertriglyceridemia (HP:0002155)1.43404142
150Cerebral ischemia (HP:0002637)1.40162814
151Muscle fibrillation (HP:0010546)1.38335571
152Aplasia/Hypoplasia of the earlobes (HP:0009906)1.37363577
153Gastrointestinal infarctions (HP:0005244)1.36861759
154Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.36367155

Predicted kinase interactions (KEA)

RankGene SetZ-score
1RIPK45.29202723
2EEF2K5.17247417
3KIT3.77335258
4BMX3.33201308
5TIE12.89652826
6PIM22.86979924
7MAP4K12.68785189
8MATK2.68358527
9MST42.54057671
10NME22.52547404
11CDC72.33223813
12TAOK32.32807840
13BTK2.20491672
14STK162.14443855
15TEC1.94308852
16RPS6KB21.93570211
17PTK2B1.88438680
18MAPKAPK51.87907986
19NEK21.85788702
20WEE11.82020311
21MYLK1.65052320
22VRK11.63963039
23PKN21.60355700
24NUAK11.60333253
25TAOK21.56354342
26KDR1.55167535
27PIM11.52375914
28TESK21.47128928
29MAPKAPK31.46393996
30TXK1.45759680
31GRK51.43301800
32MAP2K31.42679095
33TRIB31.41644521
34FGR1.41307885
35TNIK1.34543479
36TGFBR11.33591566
37SYK1.32668181
38MKNK11.32489245
39SCYL21.29118061
40BUB11.26371622
41ZAP701.25752516
42BMPR21.23587877
43JAK31.21660444
44TRPM71.20905337
45TYK21.20210727
46ADRBK21.18898924
47FES1.17406599
48CDK41.14772275
49GRK61.09196829
50CLK11.07891137
51CDK61.07879957
52TAOK11.07568125
53CCNB11.07509967
54LRRK21.05391493
55CSK1.01738479
56LYN1.00053147
57BLK0.98908025
58CDK70.97674123
59VRK20.96953867
60ATR0.94205290
61MAP3K120.94133839
62PASK0.92380896
63TSSK60.91842201
64MAP3K30.91790248
65PAK10.91591275
66DYRK30.89467646
67STK40.88772022
68CDK190.88425732
69MAP3K110.87963884
70MAP3K50.86317937
71MAPK110.86222392
72MARK30.80711776
73TNK20.76111101
74MAP4K20.75547541
75PIK3CG0.75323425
76TBK10.74963739
77JAK20.74823845
78ADRBK10.73035950
79TGFBR20.72882695
80PRKCQ0.72699822
81IRAK30.72015972
82DAPK30.71829327
83BRSK20.71772985
84EIF2AK10.69442387
85TLK10.68928287
86PAK40.67583995
87ARAF0.66896040
88IRAK40.66534536
89BCKDK0.66244120
90PLK20.65197127
91HCK0.63887338
92ITK0.63645054
93STK100.62958773
94IKBKB0.62644176
95MAPK120.61498114
96ALK0.61362863
97LCK0.60807097
98PDK10.60628191
99SIK30.59822496
100RET0.59562727
101MAP3K100.58699499
102MAP3K10.58509588
103PTK60.56928367
104FLT30.56384160
105ILK0.56301248
106AURKB0.56076921
107TTK0.55336767
108MAPK40.54362383
109MAP3K80.54114942
110MUSK0.53971101
111MKNK20.52939061
112PAK20.52475442
113PRKD10.51502259
114MAPKAPK20.49742773
115PKN10.49641509
116RAF10.49350562
117PRKACG0.49196828
118DAPK10.48952954
119SRPK10.48549209
120HIPK20.48285747
121DAPK20.48184905
122PDPK10.47269229
123PRKCD0.47249867
124CDK80.46212277
125ZAK0.45264922
126BRSK10.45154263
127CSF1R0.44012935
128PRKG20.43960923
129RPS6KA60.43568404
130JAK10.43508152
131RPS6KA40.43325557
132MAP3K60.41993499
133FYN0.40800065
134MAP3K70.40375320
135ERBB20.40207325
136IRAK10.38980442
137YES10.38606606
138PLK40.38413851
139NEK10.37847773
140STK30.37416656
141SIK20.36943836
142IKBKE0.36703279
143PRPF4B0.36495980
144RPS6KA20.36373662
145RPS6KC10.36322784
146ACVR1B0.35124191
147BMPR1B0.32457877
148MAPK30.32199147
149MAPK130.31926505
150MAP2K10.30286315
151DYRK20.30046781
152EPHA30.29510376
153LMTK20.27555453

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030305.68892024
2Ribosome_Homo sapiens_hsa030103.81604291
3Mismatch repair_Homo sapiens_hsa034303.51300726
4Asthma_Homo sapiens_hsa053103.40001989
5Renin-angiotensin system_Homo sapiens_hsa046143.26124746
6Base excision repair_Homo sapiens_hsa034102.73921958
7Homologous recombination_Homo sapiens_hsa034402.59693996
8Nitrogen metabolism_Homo sapiens_hsa009102.55441071
9* Hematopoietic cell lineage_Homo sapiens_hsa046402.50249443
10Arachidonic acid metabolism_Homo sapiens_hsa005902.41505300
11* Platelet activation_Homo sapiens_hsa046112.15764248
12Cell cycle_Homo sapiens_hsa041102.07022038
13Nucleotide excision repair_Homo sapiens_hsa034202.02455562
14Spliceosome_Homo sapiens_hsa030401.98136594
15Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.90145006
16Pyrimidine metabolism_Homo sapiens_hsa002401.72830817
17One carbon pool by folate_Homo sapiens_hsa006701.70963532
18Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.66787914
19Acute myeloid leukemia_Homo sapiens_hsa052211.66327498
20B cell receptor signaling pathway_Homo sapiens_hsa046621.50765940
21Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.49603493
22Chronic myeloid leukemia_Homo sapiens_hsa052201.48904808
23Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.48123416
24p53 signaling pathway_Homo sapiens_hsa041151.39211611
25Leishmaniasis_Homo sapiens_hsa051401.29470295
26Herpes simplex infection_Homo sapiens_hsa051681.29342959
27Endocytosis_Homo sapiens_hsa041441.29250808
28N-Glycan biosynthesis_Homo sapiens_hsa005101.28785255
29Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.28026374
30Fanconi anemia pathway_Homo sapiens_hsa034601.27244485
31Measles_Homo sapiens_hsa051621.26085233
32Serotonergic synapse_Homo sapiens_hsa047261.24537164
33Collecting duct acid secretion_Homo sapiens_hsa049661.22974168
34Primary immunodeficiency_Homo sapiens_hsa053401.21454473
35Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.20975610
36Sulfur relay system_Homo sapiens_hsa041221.19989922
37T cell receptor signaling pathway_Homo sapiens_hsa046601.19902120
38Glycerolipid metabolism_Homo sapiens_hsa005611.18445280
39Hepatitis B_Homo sapiens_hsa051611.17423440
40Vascular smooth muscle contraction_Homo sapiens_hsa042701.15452940
41Regulation of autophagy_Homo sapiens_hsa041401.13452189
42Viral carcinogenesis_Homo sapiens_hsa052031.11323894
43Apoptosis_Homo sapiens_hsa042101.11043858
44Jak-STAT signaling pathway_Homo sapiens_hsa046301.10983400
45Antigen processing and presentation_Homo sapiens_hsa046121.07864383
46Transcriptional misregulation in cancer_Homo sapiens_hsa052021.07260706
47RNA transport_Homo sapiens_hsa030131.07163727
48Systemic lupus erythematosus_Homo sapiens_hsa053221.07014204
49Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.06557521
50Toxoplasmosis_Homo sapiens_hsa051451.04824384
51alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.04494306
52Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.03605140
53Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.00662098
54Non-homologous end-joining_Homo sapiens_hsa034501.00037534
55NF-kappa B signaling pathway_Homo sapiens_hsa040640.98247234
56Glycerophospholipid metabolism_Homo sapiens_hsa005640.97123655
57Osteoclast differentiation_Homo sapiens_hsa043800.96743738
58RNA polymerase_Homo sapiens_hsa030200.96597831
59Staphylococcus aureus infection_Homo sapiens_hsa051500.96202898
60Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.94095848
61Gap junction_Homo sapiens_hsa045400.93950648
62Non-small cell lung cancer_Homo sapiens_hsa052230.92410154
63Allograft rejection_Homo sapiens_hsa053300.91337756
64Fatty acid elongation_Homo sapiens_hsa000620.90831442
65Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.90299730
66Graft-versus-host disease_Homo sapiens_hsa053320.89092265
67Pentose phosphate pathway_Homo sapiens_hsa000300.88806065
68Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.87142698
69Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.86780793
70Shigellosis_Homo sapiens_hsa051310.85277302
71Olfactory transduction_Homo sapiens_hsa047400.83748244
72Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.81941862
73Phagosome_Homo sapiens_hsa041450.81759406
74RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.81137439
75Pancreatic secretion_Homo sapiens_hsa049720.81087995
76Epstein-Barr virus infection_Homo sapiens_hsa051690.80674483
77Legionellosis_Homo sapiens_hsa051340.80108839
78Autoimmune thyroid disease_Homo sapiens_hsa053200.77015871
79RNA degradation_Homo sapiens_hsa030180.75874916
80Glutathione metabolism_Homo sapiens_hsa004800.75551609
81Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.74117903
82Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.73330270
83Intestinal immune network for IgA production_Homo sapiens_hsa046720.69126279
84Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.68038043
85Purine metabolism_Homo sapiens_hsa002300.67858884
86Salmonella infection_Homo sapiens_hsa051320.66470251
87Pancreatic cancer_Homo sapiens_hsa052120.62805130
88Long-term depression_Homo sapiens_hsa047300.62423533
89Cysteine and methionine metabolism_Homo sapiens_hsa002700.61747316
90Other glycan degradation_Homo sapiens_hsa005110.61147158
91Thyroid cancer_Homo sapiens_hsa052160.60581534
92Proteasome_Homo sapiens_hsa030500.58917235
93Influenza A_Homo sapiens_hsa051640.58593632
94HTLV-I infection_Homo sapiens_hsa051660.58312872
95SNARE interactions in vesicular transport_Homo sapiens_hsa041300.57730940
96Linoleic acid metabolism_Homo sapiens_hsa005910.55602442
97* Small cell lung cancer_Homo sapiens_hsa052220.54248576
98Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.53141703
99Toll-like receptor signaling pathway_Homo sapiens_hsa046200.53136401
100AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.52652766
101* Regulation of actin cytoskeleton_Homo sapiens_hsa048100.51666139
102mRNA surveillance pathway_Homo sapiens_hsa030150.49446833
103ABC transporters_Homo sapiens_hsa020100.47662920
104Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.47570368
105Drug metabolism - other enzymes_Homo sapiens_hsa009830.47414075
106Sulfur metabolism_Homo sapiens_hsa009200.46874836
107Phosphatidylinositol signaling system_Homo sapiens_hsa040700.46482722
108Calcium signaling pathway_Homo sapiens_hsa040200.46215991
109Amoebiasis_Homo sapiens_hsa051460.44768203
110Alcoholism_Homo sapiens_hsa050340.44676575
111Choline metabolism in cancer_Homo sapiens_hsa052310.44479918
112Adipocytokine signaling pathway_Homo sapiens_hsa049200.43726503
113Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.43686943
114African trypanosomiasis_Homo sapiens_hsa051430.43183193
115Neurotrophin signaling pathway_Homo sapiens_hsa047220.42680739
116Pertussis_Homo sapiens_hsa051330.42525800
117Folate biosynthesis_Homo sapiens_hsa007900.41828120
118Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.41544423
119Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.41466008
120Chemokine signaling pathway_Homo sapiens_hsa040620.41118066
121Colorectal cancer_Homo sapiens_hsa052100.40704878
122Glycosaminoglycan degradation_Homo sapiens_hsa005310.40124643
123Rheumatoid arthritis_Homo sapiens_hsa053230.39688610
124* ECM-receptor interaction_Homo sapiens_hsa045120.39645280
125NOD-like receptor signaling pathway_Homo sapiens_hsa046210.39141228
126Malaria_Homo sapiens_hsa051440.35776174
127VEGF signaling pathway_Homo sapiens_hsa043700.35291383
128Endometrial cancer_Homo sapiens_hsa052130.35168095
129Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.35158358
130Type I diabetes mellitus_Homo sapiens_hsa049400.34331202
131Morphine addiction_Homo sapiens_hsa050320.34012753
132TNF signaling pathway_Homo sapiens_hsa046680.33525345
133Phototransduction_Homo sapiens_hsa047440.33427727
134Steroid hormone biosynthesis_Homo sapiens_hsa001400.33176980
135Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.32306834
136Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.30517724
137Protein export_Homo sapiens_hsa030600.29864989
138Tuberculosis_Homo sapiens_hsa051520.28496427
139Galactose metabolism_Homo sapiens_hsa000520.28260300
140Leukocyte transendothelial migration_Homo sapiens_hsa046700.27427940
141Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.27146685
142MicroRNAs in cancer_Homo sapiens_hsa052060.26956305
143HIF-1 signaling pathway_Homo sapiens_hsa040660.24665152
144Sphingolipid signaling pathway_Homo sapiens_hsa040710.23296099
145Basal transcription factors_Homo sapiens_hsa030220.22383159
146* PI3K-Akt signaling pathway_Homo sapiens_hsa041510.21553301
147Phospholipase D signaling pathway_Homo sapiens_hsa040720.20882437
148Vitamin B6 metabolism_Homo sapiens_hsa007500.19353032

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