ITGA4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The gene encodes a member of the integrin alpha chain family of proteins. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain that function in cell surface adhesion and signaling. The encoded preproprotein is proteolytically processed to generate light and heavy chains that comprise the alpha 4 subunit. This subunit associates with a beta 1 or beta 7 subunit to form an integrin that may play a role in cell motility and migration. This integrin is a therapeutic target for the treatment of multiple sclerosis, Crohn's disease and inflammatory bowel disease. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of gamma-delta T cell activation (GO:0046645)6.77281619
2negative regulation of leukocyte mediated cytotoxicity (GO:0001911)5.61974185
3negative regulation of cell killing (GO:0031342)5.61974185
4antigen processing and presentation of endogenous peptide antigen (GO:0002483)5.48606364
5antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)5.48606364
6antigen processing and presentation of endogenous antigen (GO:0019883)5.21626140
7negative T cell selection (GO:0043383)5.14596428
8antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.08728336
9negative thymic T cell selection (GO:0045060)5.07967558
10regulation of gamma-delta T cell differentiation (GO:0045586)4.81243210
11regulation of gamma-delta T cell activation (GO:0046643)4.69661066
12regulation of B cell receptor signaling pathway (GO:0050855)4.65464178
13positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)4.64046369
14positive thymic T cell selection (GO:0045059)4.53340673
15interferon-gamma production (GO:0032609)4.25912596
16* T cell migration (GO:0072678)4.15451063
17thymic T cell selection (GO:0045061)4.06065439
18positive T cell selection (GO:0043368)3.99819155
19regulation of B cell differentiation (GO:0045577)3.97308753
20positive regulation of B cell differentiation (GO:0045579)3.96880015
21T cell selection (GO:0045058)3.96547866
22B cell receptor signaling pathway (GO:0050853)3.90148381
23response to interleukin-15 (GO:0070672)3.90084384
24NIK/NF-kappaB signaling (GO:0038061)3.90061581
25leukocyte aggregation (GO:0070486)3.81889893
26negative regulation of erythrocyte differentiation (GO:0045647)3.78370299
27Peyers patch development (GO:0048541)3.68889019
28mucosal-associated lymphoid tissue development (GO:0048537)3.68889019
29cellular response to interleukin-15 (GO:0071350)3.65429744
30positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.53930547
31regulation of alpha-beta T cell proliferation (GO:0046640)3.53809316
32regulation of interleukin-12 biosynthetic process (GO:0045075)3.53559136
33regulation of antigen receptor-mediated signaling pathway (GO:0050854)3.50692544
34positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.47222290
35response to peptidoglycan (GO:0032494)3.46798163
36positive regulation by organism of defense response of other organism involved in symbiotic interact3.45552575
37modulation by symbiont of host immune response (GO:0052553)3.45552575
38positive regulation by symbiont of host defense response (GO:0052509)3.45552575
39modulation by symbiont of host defense response (GO:0052031)3.45552575
40modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.45552575
41modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.45552575
42regulation of isotype switching to IgG isotypes (GO:0048302)3.42372013
43neutrophil activation (GO:0042119)3.42242844
44positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)3.38774758
45regulation of granulocyte differentiation (GO:0030852)3.38612657
46negative regulation of T cell mediated immunity (GO:0002710)3.33043939
47tolerance induction (GO:0002507)3.31309975
48regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.29685498
49regulation of tolerance induction (GO:0002643)3.29392409
50positive regulation of isotype switching (GO:0045830)3.28913080
51microglial cell activation (GO:0001774)3.28468878
52activated T cell proliferation (GO:0050798)3.27974443
53T cell homeostasis (GO:0043029)3.26948514
54detection of other organism (GO:0098543)3.26640690
55antigen receptor-mediated signaling pathway (GO:0050851)3.23612139
56response to type I interferon (GO:0034340)3.22323985
57mast cell activation involved in immune response (GO:0002279)3.21687246
58mast cell degranulation (GO:0043303)3.21687246
59mast cell activation (GO:0045576)3.21349992
60myeloid dendritic cell activation (GO:0001773)3.19107575
61positive regulation of interleukin-2 production (GO:0032743)3.17644624
62regulation of T cell receptor signaling pathway (GO:0050856)3.16549216
63negative regulation of leukocyte mediated immunity (GO:0002704)3.16448350
64type I interferon signaling pathway (GO:0060337)3.15976111
65cellular response to type I interferon (GO:0071357)3.15976111
66granulocyte activation (GO:0036230)3.14720552
67T cell receptor signaling pathway (GO:0050852)3.14393117
68response to muramyl dipeptide (GO:0032495)3.12970027
69regulation of T cell tolerance induction (GO:0002664)3.12301176
70mature B cell differentiation (GO:0002335)3.11501882
71neutrophil activation involved in immune response (GO:0002283)3.11440091
72macrophage activation involved in immune response (GO:0002281)3.09058479
73lymphocyte homeostasis (GO:0002260)3.07711942
74* leukocyte cell-cell adhesion (GO:0007159)3.07569228
75detection of bacterium (GO:0016045)3.07467590
76positive regulation of alpha-beta T cell proliferation (GO:0046641)3.06921498
77T cell costimulation (GO:0031295)3.06006472
78positive regulation of interferon-alpha production (GO:0032727)3.05810668
79B cell homeostasis (GO:0001782)3.05728392
80leukocyte degranulation (GO:0043299)3.04201299
81regulation of interferon-beta biosynthetic process (GO:0045357)3.03291789
82natural killer cell activation (GO:0030101)3.02962588
83T cell proliferation (GO:0042098)3.02736141
84lymphocyte costimulation (GO:0031294)3.01103295
85antigen processing and presentation via MHC class Ib (GO:0002475)2.99950222
86immunoglobulin mediated immune response (GO:0016064)2.99622054
87interferon-gamma-mediated signaling pathway (GO:0060333)2.97587695
88response to host immune response (GO:0052572)2.97570131
89response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.97570131
90megakaryocyte development (GO:0035855)2.97359481
91natural killer cell differentiation (GO:0001779)2.96476297
92regulation of interferon-alpha production (GO:0032647)2.96445838
93negative regulation of adaptive immune response based on somatic recombination of immune receptors b2.95624205
94Arp2/3 complex-mediated actin nucleation (GO:0034314)2.94535376
95regulation of type I interferon-mediated signaling pathway (GO:0060338)2.92293735
96negative regulation of phagocytosis (GO:0050765)2.90973284
97positive regulation of antigen processing and presentation (GO:0002579)2.90932342
98cellular extravasation (GO:0045123)2.90428000
99detection of molecule of bacterial origin (GO:0032490)2.90098685
100detection of external biotic stimulus (GO:0098581)2.88085847
101positive regulation of granulocyte differentiation (GO:0030854)2.87792859
102negative regulation of interleukin-12 production (GO:0032695)2.86948749
103regulation of mast cell degranulation (GO:0043304)2.86103132
104negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)2.84992857
105germinal center formation (GO:0002467)2.83875547
106positive regulation of DNA recombination (GO:0045911)2.82788522
107negative regulation of B cell proliferation (GO:0030889)2.82214009
108positive regulation of mast cell activation (GO:0033005)2.80984493
109alpha-beta T cell activation (GO:0046631)2.80977690
110neutrophil mediated immunity (GO:0002446)2.79974402
111negative regulation of adaptive immune response (GO:0002820)2.79837270
112respiratory burst (GO:0045730)2.79744770
113positive regulation of tolerance induction (GO:0002645)2.79171080
114defense response to protozoan (GO:0042832)2.79054181
115myeloid cell activation involved in immune response (GO:0002275)2.77724818
116myeloid dendritic cell differentiation (GO:0043011)2.77718510
117regulation of hypersensitivity (GO:0002883)2.77549669
118regulation of alpha-beta T cell activation (GO:0046634)2.77222969
119response to host defenses (GO:0052200)2.76511658
120response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.76511658
121response to host (GO:0075136)2.76511658
122positive regulation of B cell activation (GO:0050871)2.75359852
123positive regulation of humoral immune response (GO:0002922)2.74321073
124response to protozoan (GO:0001562)2.74232812
125hepatocyte apoptotic process (GO:0097284)2.72535409
126regulation of natural killer cell mediated cytotoxicity (GO:0042269)2.71629163
127regulation of natural killer cell mediated immunity (GO:0002715)2.71629163
128positive regulation of immunoglobulin mediated immune response (GO:0002891)2.71319072
129positive regulation of B cell mediated immunity (GO:0002714)2.71319072
130negative regulation of lymphocyte mediated immunity (GO:0002707)2.70823402
131leukocyte homeostasis (GO:0001776)2.68643228
132regulation of necroptotic process (GO:0060544)2.67443772
133regulation of response to interferon-gamma (GO:0060330)2.65805280
134B cell proliferation (GO:0042100)2.64928258

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP3_17237761_ChIP-ChIP_TREG_Mouse5.92894997
2IRF8_22096565_ChIP-ChIP_GC-B_Human5.33376024
3E2F7_22180533_ChIP-Seq_HELA_Human5.13233942
4STAT6_20620947_ChIP-Seq_CD4_POS_T_Human4.96015779
5IRF8_22096565_ChIP-ChIP_GC-B_Mouse4.07458349
6IRF8_21731497_ChIP-ChIP_J774_Mouse3.91570126
7* MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.67787198
8IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.40051979
9EGR1_19374776_ChIP-ChIP_THP-1_Human3.31808409
10STAT3_20064451_ChIP-Seq_CD4+T_Mouse3.25889927
11SCL_19346495_ChIP-Seq_HPC-7_Human3.00230662
12IRF8_27001747_Chip-Seq_BMDM_Mouse2.99284170
13* SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.98958041
14MYC_22102868_ChIP-Seq_BL_Human2.96659642
15* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.93528538
16* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.93244198
17* RUNX_20019798_ChIP-Seq_JUKART_Human2.89171233
18STAT4_19710469_ChIP-ChIP_TH1__Mouse2.80591968
19* MYB_26560356_Chip-Seq_TH2_Human2.79377437
20* MYB_21317192_ChIP-Seq_ERMYB_Mouse2.67861349
21NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.66389410
22BP1_19119308_ChIP-ChIP_Hs578T_Human2.53293150
23* MYB_26560356_Chip-Seq_TH1_Human2.46777905
24VDR_21846776_ChIP-Seq_THP-1_Human2.45585819
25* MAF_26560356_Chip-Seq_TH1_Human2.44722191
26NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.25598721
27* SPI1_23547873_ChIP-Seq_NB4_Human2.25189100
28SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.23345696
29RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.18253262
30FOXM1_23109430_ChIP-Seq_U2OS_Human2.15387358
31UTX_26944678_Chip-Seq_JUKART_Human2.14786830
32ASXL1_24218140_ChIP-Seq_BMDM_Mouse2.10462533
33RUNX1_22412390_ChIP-Seq_EML_Mouse2.01085071
34* BRD4_27068464_Chip-Seq_AML-cells_Mouse1.99626502
35VDR_24763502_ChIP-Seq_THP-1_Human1.96479606
36TCF7_22412390_ChIP-Seq_EML_Mouse1.94074892
37VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.84096704
38GATA1_22025678_ChIP-Seq_K562_Human1.83770611
39CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.74919797
40E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.73414239
41SPI1_23127762_ChIP-Seq_K562_Human1.71759389
42* GATA3_27048872_Chip-Seq_THYMUS_Human1.69273231
43* FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.67166625
44E2F4_17652178_ChIP-ChIP_JURKAT_Human1.64469551
45* KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.57170957
46MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.55551332
47* PU_27001747_Chip-Seq_BMDM_Mouse1.54705501
48NOTCH1_21737748_ChIP-Seq_TLL_Human1.54696550
49ELF1_17652178_ChIP-ChIP_JURKAT_Human1.52268145
50MAF_26560356_Chip-Seq_TH2_Human1.48296986
51RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.46999748
52TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.45822341
53GATA2_22383799_ChIP-Seq_G1ME_Mouse1.45236350
54* TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.42864542
55LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.42730584
56SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.41961924
57CIITA_25753668_ChIP-Seq_RAJI_Human1.41026864
58Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.40319194
59SMAD_19615063_ChIP-ChIP_OVARY_Human1.36688229
60NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.33497038
61STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.31567701
62* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.30905087
63* RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.29861052
64KDM2B_26808549_Chip-Seq_DND41_Human1.26529944
65* GATA1_19941827_ChIP-Seq_MEL_Mouse1.26478412
66PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.25946133
67GATA3_26560356_Chip-Seq_TH2_Human1.25680748
68* GATA1_22383799_ChIP-Seq_G1ME_Mouse1.22164303
69HOXB4_20404135_ChIP-ChIP_EML_Mouse1.19338453
70LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.18521972
71SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.18266574
72GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.17172018
73BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.15046002
74CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.13887969
75VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.12992770
76* ERG_20887958_ChIP-Seq_HPC-7_Mouse1.12454151
77SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.10797243
78VDR_24787735_ChIP-Seq_THP-1_Human1.07028832
79* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.04376030
80NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.04327212
81FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.03489862
82CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.00979330
83GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.98021542
84GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.96139471
85* PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.94373749
86E2F1_21310950_ChIP-Seq_MCF-7_Human0.93868584
87FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human0.93806265
88PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.93372592
89* RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.90476344
90GATA1_19941826_ChIP-Seq_K562_Human0.88754012
91ELK3_25401928_ChIP-Seq_HUVEC_Human0.86773568
92GATA2_19941826_ChIP-Seq_K562_Human0.85145500
93CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.84977163
94SMRT_27268052_Chip-Seq_Bcells_Human0.83440965
95NCOR1_26117541_ChIP-Seq_K562_Human0.82767171
96ETS1_22383799_ChIP-Seq_G1ME_Mouse0.81432002
97* GATA3_26560356_Chip-Seq_TH1_Human0.80685180
98VDR_23849224_ChIP-Seq_CD4+_Human0.80066680
99PU.1_20513432_ChIP-Seq_Bcells_Mouse0.79832332
100GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.79322917
101* FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.79306125
102SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.77975527
103CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.77758173
104GATA2_21666600_ChIP-Seq_HMVEC_Human0.77710403
105STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.77666389
106FOXP3_21729870_ChIP-Seq_TREG_Human0.75763769
107ELK1_19687146_ChIP-ChIP_HELA_Human0.75206013
108* KDM2B_26808549_Chip-Seq_JURKAT_Human0.72445395
109PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.70167872
110TFEB_21752829_ChIP-Seq_HELA_Human0.68528920

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation4.02844813
2MP0005671_abnormal_response_to3.52137407
3MP0000685_abnormal_immune_system3.38604021
4MP0001800_abnormal_humoral_immune3.29460736
5MP0003763_abnormal_thymus_physiology3.24853473
6MP0005387_immune_system_phenotype3.12286200
7MP0001790_abnormal_immune_system3.12286200
8MP0005000_abnormal_immune_tolerance2.88840869
9MP0002396_abnormal_hematopoietic_system2.87485133
10* MP0002452_abnormal_antigen_presenting2.82016538
11MP0002723_abnormal_immune_serum2.78374676
12* MP0002420_abnormal_adaptive_immunity2.74582177
13* MP0001819_abnormal_immune_cell2.72867608
14MP0009785_altered_susceptibility_to2.70947910
15* MP0002398_abnormal_bone_marrow2.67055778
16MP0002166_altered_tumor_susceptibility2.65434977
17MP0005025_abnormal_response_to2.59393813
18MP0003436_decreased_susceptibility_to2.59160465
19MP0000569_abnormal_digit_pigmentation2.45065686
20* MP0002419_abnormal_innate_immunity2.40532644
21MP0002148_abnormal_hypersensitivity_rea2.36120678
22* MP0000716_abnormal_immune_system2.35347879
23MP0001873_stomach_inflammation2.32975710
24MP0003303_peritoneal_inflammation2.28416328
25MP0002006_tumorigenesis2.25751643
26MP0005464_abnormal_platelet_physiology2.17137794
27MP0004808_abnormal_hematopoietic_stem2.15294502
28MP0000689_abnormal_spleen_morphology2.13055142
29MP0002405_respiratory_system_inflammati2.09169227
30* MP0002722_abnormal_immune_system2.07362845
31MP0000703_abnormal_thymus_morphology1.99218464
32MP0006082_CNS_inflammation1.98135700
33* MP0002429_abnormal_blood_cell1.97207992
34MP0004381_abnormal_hair_follicle1.94565523
35MP0005174_abnormal_tail_pigmentation1.93490405
36MP0009333_abnormal_splenocyte_physiolog1.93437322
37MP0001545_abnormal_hematopoietic_system1.93279149
38MP0005397_hematopoietic_system_phenotyp1.93279149
39MP0010155_abnormal_intestine_physiology1.90105694
40MP0003300_gastrointestinal_ulcer1.87852661
41MP0009278_abnormal_bone_marrow1.84486675
42MP0004947_skin_inflammation1.81925017
43MP0003724_increased_susceptibility_to1.79679135
44MP0001845_abnormal_inflammatory_respons1.68803122
45MP0004510_myositis1.64283728
46MP0001853_heart_inflammation1.60727339
47MP0008057_abnormal_DNA_replication1.49587395
48MP0000465_gastrointestinal_hemorrhage1.46408882
49MP0008260_abnormal_autophagy1.44023187
50MP0000490_abnormal_crypts_of1.41160266
51MP0000858_altered_metastatic_potential1.38685412
52MP0003866_abnormal_defecation1.38241347
53MP0005310_abnormal_salivary_gland1.38130544
54MP0003448_altered_tumor_morphology1.32066471
55MP0002009_preneoplasia1.29346427
56MP0010352_gastrointestinal_tract_polyps1.27368019
57MP0002933_joint_inflammation1.22101578
58MP0008469_abnormal_protein_level1.20776429
59MP0000015_abnormal_ear_pigmentation1.20577771
60MP0003172_abnormal_lysosome_physiology1.19543075
61MP0001533_abnormal_skeleton_physiology1.16729717
62MP0010307_abnormal_tumor_latency1.11713257
63MP0002138_abnormal_hepatobiliary_system1.11147498
64MP0003183_abnormal_peptide_metabolism1.08177716
65MP0004883_abnormal_blood_vessel1.07695162
66MP0002019_abnormal_tumor_incidence1.04463560
67MP0010094_abnormal_chromosome_stability1.03570132
68MP0005075_abnormal_melanosome_morpholog1.03525377
69MP0005058_abnormal_lysosome_morphology0.99761113
70MP0005451_abnormal_body_composition0.99305210
71MP0003191_abnormal_cellular_cholesterol0.97988382
72MP0002095_abnormal_skin_pigmentation0.97477615
73MP0009764_decreased_sensitivity_to0.94978048
74MP0003077_abnormal_cell_cycle0.93803212
75MP0003656_abnormal_erythrocyte_physiolo0.90479358
76MP0005076_abnormal_cell_differentiation0.88898760
77MP0002998_abnormal_bone_remodeling0.87419785
78MP0005164_abnormal_response_to0.81728475
79MP0003111_abnormal_nucleus_morphology0.81266436
80MP0009765_abnormal_xenobiotic_induced0.75977520
81MP0000371_diluted_coat_color0.75158777
82MP0001851_eye_inflammation0.74181833
83MP0003221_abnormal_cardiomyocyte_apopto0.73608182
84MP0002877_abnormal_melanocyte_morpholog0.73498132
85MP0006054_spinal_hemorrhage0.73234118
86MP0009763_increased_sensitivity_to0.72359387
87MP0008007_abnormal_cellular_replicative0.71657984
88MP0002132_abnormal_respiratory_system0.71561639
89MP0008877_abnormal_DNA_methylation0.70533812
90MP0003693_abnormal_embryo_hatching0.70162201
91MP0008058_abnormal_DNA_repair0.69998249
92MP0003787_abnormal_imprinting0.69290653
93MP0003828_pulmonary_edema0.69112450
94MP0003045_fibrosis0.68983933
95MP0000604_amyloidosis0.65484626
96MP0003091_abnormal_cell_migration0.65272190
97MP0003943_abnormal_hepatobiliary_system0.64271702
98MP0002928_abnormal_bile_duct0.63238747
99MP0000313_abnormal_cell_death0.62736752
100MP0003566_abnormal_cell_adhesion0.62697303
101MP0001663_abnormal_digestive_system0.62581787
102MP0004185_abnormal_adipocyte_glucose0.62265992
103MP0001986_abnormal_taste_sensitivity0.56476561
104MP0005390_skeleton_phenotype0.55878534
105MP0000343_altered_response_to0.55244574
106MP0002136_abnormal_kidney_physiology0.53496460
107MP0004130_abnormal_muscle_cell0.53479246
108MP0000249_abnormal_blood_vessel0.51506910
109MP0003279_aneurysm0.50951004
110MP0008961_abnormal_basal_metabolism0.50803953
111MP0003690_abnormal_glial_cell0.50803559
112MP0003453_abnormal_keratinocyte_physiol0.50117683
113MP0003795_abnormal_bone_structure0.48983890
114MP0005166_decreased_susceptibility_to0.48922572
115* MP0005621_abnormal_cell_physiology0.47817105
116MP0001191_abnormal_skin_condition0.45999929
117MP0008873_increased_physiological_sensi0.45968365
118MP0003075_altered_response_to0.44855979
119MP0002163_abnormal_gland_morphology0.43762401

Predicted human phenotypes

RankGene SetZ-score
1Recurrent viral infections (HP:0004429)4.84805066
2Recurrent abscess formation (HP:0002722)4.76310418
3T lymphocytopenia (HP:0005403)4.59894513
4Abnormality of T cell number (HP:0011839)4.46160061
5Recurrent fungal infections (HP:0002841)4.41782707
6Myositis (HP:0100614)4.34038304
7Recurrent bacterial skin infections (HP:0005406)4.28021305
8Eczematoid dermatitis (HP:0000976)3.99897441
9Abnormal delayed hypersensitivity skin test (HP:0002963)3.94247829
10Abnormality of the fingertips (HP:0001211)3.91189145
11Chronic otitis media (HP:0000389)3.90767494
12IgM deficiency (HP:0002850)3.86949841
13Retrobulbar optic neuritis (HP:0100654)3.81608529
14Optic neuritis (HP:0100653)3.81608529
15Panhypogammaglobulinemia (HP:0003139)3.81365581
16Agammaglobulinemia (HP:0004432)3.77828906
17Elevated erythrocyte sedimentation rate (HP:0003565)3.71274816
18Meningitis (HP:0001287)3.70776216
19Abnormality of T cells (HP:0002843)3.59806920
20Recurrent bronchitis (HP:0002837)3.55718268
21Recurrent cutaneous fungal infections (HP:0011370)3.52134637
22Chronic mucocutaneous candidiasis (HP:0002728)3.52134637
23Orchitis (HP:0100796)3.49643438
24Mediastinal lymphadenopathy (HP:0100721)3.44409485
25Vasculitis (HP:0002633)3.38446192
26Autoimmune thrombocytopenia (HP:0001973)3.34703493
27Pustule (HP:0200039)3.32057843
28Nasal polyposis (HP:0100582)3.31732163
29Inflammation of the large intestine (HP:0002037)3.28118204
30Thyroiditis (HP:0100646)3.26214486
31Prolonged bleeding time (HP:0003010)3.26180445
32Cellulitis (HP:0100658)3.25758819
33Recurrent skin infections (HP:0001581)3.24584887
34Gastrointestinal inflammation (HP:0004386)3.14570237
35Colitis (HP:0002583)3.10415182
36Parkinsonism with favorable response to dopaminergic medication (HP:0002548)3.04897460
37Eosinophilia (HP:0001880)3.01879266
38Spontaneous hematomas (HP:0007420)2.99660033
39Obstructive lung disease (HP:0006536)2.99465507
40Chronic obstructive pulmonary disease (HP:0006510)2.99465507
41Encephalitis (HP:0002383)2.95927763
42Leukocytosis (HP:0001974)2.88012977
43B lymphocytopenia (HP:0010976)2.87639816
44Abnormality of B cell number (HP:0010975)2.87639816
45Pulmonary infiltrates (HP:0002113)2.85254980
46Arterial thrombosis (HP:0004420)2.81731999
47Periodontitis (HP:0000704)2.81698870
48Abnormality of the nasal mucosa (HP:0000433)2.81069031
49Lymphopenia (HP:0001888)2.80069044
50IgG deficiency (HP:0004315)2.75991572
51Abnormality of T cell physiology (HP:0011840)2.75114437
52Recurrent gram-negative bacterial infections (HP:0005420)2.74828875
53Abnormality of eosinophils (HP:0001879)2.73417746
54Severe combined immunodeficiency (HP:0004430)2.73326919
55Thrombocytosis (HP:0001894)2.73307745
56Abnormality of cells of the lymphoid lineage (HP:0012140)2.71104968
57Granulocytopenia (HP:0001913)2.68687243
58Verrucae (HP:0200043)2.66439902
59Papilloma (HP:0012740)2.66439902
60Keratoconjunctivitis sicca (HP:0001097)2.66246322
61Epistaxis (HP:0000421)2.65205006
62Viral hepatitis (HP:0006562)2.64571000
63Combined immunodeficiency (HP:0005387)2.63076678
64Increased IgM level (HP:0003496)2.60931330
65Petechiae (HP:0000967)2.59663426
66Hemoptysis (HP:0002105)2.57061586
67Abnormality of macrophages (HP:0004311)2.55047130
68Increased IgE level (HP:0003212)2.51606403
69Urticaria (HP:0001025)2.51492935
70Abnormality of the prostate (HP:0008775)2.49879467
71Stomatitis (HP:0010280)2.47024663
72Gingival bleeding (HP:0000225)2.45178542
73Keratoconjunctivitis (HP:0001096)2.39666242
74Chronic diarrhea (HP:0002028)2.39559891
75Chest pain (HP:0100749)2.36198220
76Osteomyelitis (HP:0002754)2.36153913
77Gastrointestinal infarctions (HP:0005244)2.32907757
78Gingivitis (HP:0000230)2.31568736
79Papilledema (HP:0001085)2.29687543
80Lymphoma (HP:0002665)2.29555756
81IgA deficiency (HP:0002720)2.29031877
82Acute myeloid leukemia (HP:0004808)2.28804160
83Acute hepatic failure (HP:0006554)2.27494240
84Recurrent sinusitis (HP:0011108)2.27441835
85Hematochezia (HP:0002573)2.26731920
86Chronic sinusitis (HP:0011109)2.25349068
87Acute lymphatic leukemia (HP:0006721)2.24819012
88Gastrointestinal stroma tumor (HP:0100723)2.23729800
89Spondylolisthesis (HP:0003302)2.22140560
90Aplasia/Hypoplasia of the thymus (HP:0010515)2.16711256
91Slow saccadic eye movements (HP:0000514)2.15502666
92Impaired platelet aggregation (HP:0003540)2.14310777
93Abnormal platelet function (HP:0011869)2.14310777
94Autoimmune hemolytic anemia (HP:0001890)2.08846995
95Hypoplasia of the thymus (HP:0000778)2.08186902
96Peritonitis (HP:0002586)2.07379757
97Abnormal platelet volume (HP:0011876)2.05532211
98Prostate neoplasm (HP:0100787)2.04790054
99Absent frontal sinuses (HP:0002688)2.00598341
100Recurrent pneumonia (HP:0006532)1.98720273
101Joint swelling (HP:0001386)1.98059122
102Microcytic anemia (HP:0001935)1.97918008
103Hypergammaglobulinemia (HP:0010702)1.97015783
104Abnormality of the pleura (HP:0002103)1.96115628
105Fatigue (HP:0012378)1.95640489
106Skin ulcer (HP:0200042)1.94882883
107Abnormality of the peritoneum (HP:0002585)1.94376928
108Pulmonary embolism (HP:0002204)1.93194758
109Anorexia (HP:0002039)1.92454554
110Hypochromic anemia (HP:0001931)1.91691813
111Gangrene (HP:0100758)1.90531368
112Sepsis (HP:0100806)1.90121739
113Recurrent lower respiratory tract infections (HP:0002783)1.89566552
114Skin rash (HP:0000988)1.89468699
115Interstitial pulmonary disease (HP:0006530)1.88697257
116Bronchitis (HP:0012387)1.86316939
117Glomerulopathy (HP:0100820)1.86271415
118Emphysema (HP:0002097)1.84850270
119Amaurosis fugax (HP:0100576)1.83732938
120Spinal cord lesions (HP:0100561)1.83219676

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K14.72528290
2TXK3.55849602
3JAK33.15888958
4TYK23.09293960
5MAP3K143.05336415
6PRPF4B3.04316847
7MAP3K132.28694551
8JAK12.25068596
9ITK2.24792642
10STK102.22261905
11IKBKE2.19647084
12IRAK42.14719320
13MAP3K102.04857182
14KIT2.04102888
15ZAP701.96948589
16BTK1.91682785
17GRK61.90782892
18TAOK31.85104267
19TBK11.84809771
20BLK1.83236943
21SYK1.81314817
22BMPR21.72502197
23TEC1.70146563
24IKBKB1.69715776
25FGFR31.68664819
26PIK3CG1.66636188
27CDK121.66443913
28RIPK41.65599173
29EEF2K1.62603779
30CSK1.58944165
31LCK1.57202151
32SIK21.50193900
33PIM11.47415740
34FGFR41.46867795
35HCK1.42540306
36IRAK31.39842735
37CSF1R1.38254684
38FES1.34312658
39CLK11.19122456
40CHUK1.16355658
41NLK1.15132839
42STK41.14145873
43MARK31.13053858
44RPS6KA41.07561433
45LYN1.05825859
46CDK41.00627051
47JAK20.99843663
48TGFBR20.99211116
49SCYL20.95137238
50PRKCQ0.93960831
51LRRK20.92953288
52BRD40.90594956
53SIK30.89178305
54TESK20.88990795
55CAMKK20.87493127
56EPHB10.86778804
57NEK20.85741630
58CDK90.83404344
59FLT30.82246142
60FGR0.81385894
61TRPM70.80605396
62TNK20.77174119
63CDK190.74629453
64MAP3K10.72967682
65CDK60.72184916
66MAP2K30.71622953
67WNK10.71033758
68HIPK20.70734945
69STK240.70603872
70MARK20.62652486
71CAMK1D0.62409441
72MELK0.61796608
73CDC70.61464592
74ATR0.61318074
75PASK0.60792975
76TTN0.60635549
77MAP3K70.59541094
78MAP3K30.59438455
79EPHA30.57328434
80PRKCH0.57223939
81TAOK20.57194456
82CAMKK10.55849076
83NUAK10.55569769
84CAMK1G0.53495350
85MST40.51144182
86PKN20.49672992
87NEK90.48807757
88SGK20.47817245
89ERN10.47648745
90MAP3K110.47405923
91SGK30.46047597
92MAPK110.44416263
93PDGFRB0.44009918
94STK30.42387438
95MAP3K50.41847025
96NME20.41300887
97PTK60.40971212
98GRK70.40036720
99MATK0.40021288
100RAF10.39885326
101RPS6KA50.39696324
102FRK0.39653559
103PDK10.38770357
104MAP3K60.38473950
105TRIB30.38445330
106RPS6KC10.37261742
107RPS6KL10.37261742
108KDR0.37071094
109RPS6KA60.36832437
110TAOK10.36426853
111ALK0.36217084
112MAP2K60.35448571
113PDPK10.35143624
114MAP2K20.33942807
115GRK50.33657970
116ABL10.33505931
117RPS6KB20.33411874
118SMG10.33194638
119EGFR0.32662387
120PIK3CA0.32226033
121IRAK20.32140757
122RET0.32059379
123MAPK40.32022359
124EIF2AK20.31838470
125MAPKAPK20.31459303
126YES10.31214241
127PRKAA20.29916453
128MAPK30.28456577
129MAPK70.27934376
130FYN0.27793865
131MAP3K80.27510122
132MAPK120.26873036
133IRAK10.26730812
134DMPK0.26346413

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053403.61063233
2NF-kappa B signaling pathway_Homo sapiens_hsa040642.66708635
3Measles_Homo sapiens_hsa051622.50340998
4B cell receptor signaling pathway_Homo sapiens_hsa046622.49522221
5Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.42942971
6Graft-versus-host disease_Homo sapiens_hsa053322.41133001
7Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.35177510
8* Leishmaniasis_Homo sapiens_hsa051402.34686188
9Antigen processing and presentation_Homo sapiens_hsa046122.23426086
10T cell receptor signaling pathway_Homo sapiens_hsa046602.19910563
11Osteoclast differentiation_Homo sapiens_hsa043802.19109671
12* Intestinal immune network for IgA production_Homo sapiens_hsa046722.06651555
13NOD-like receptor signaling pathway_Homo sapiens_hsa046211.96006119
14Allograft rejection_Homo sapiens_hsa053301.93562822
15RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.89613605
16Herpes simplex infection_Homo sapiens_hsa051681.87730057
17Toll-like receptor signaling pathway_Homo sapiens_hsa046201.87458030
18* Hematopoietic cell lineage_Homo sapiens_hsa046401.83804648
19Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.82037223
20Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.62260023
21Influenza A_Homo sapiens_hsa051641.60359149
22Toxoplasmosis_Homo sapiens_hsa051451.55287875
23Jak-STAT signaling pathway_Homo sapiens_hsa046301.52211052
24Chemokine signaling pathway_Homo sapiens_hsa040621.52057968
25TNF signaling pathway_Homo sapiens_hsa046681.48202364
26Hepatitis B_Homo sapiens_hsa051611.46227439
27Viral myocarditis_Homo sapiens_hsa054161.44939527
28Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.43049038
29Staphylococcus aureus infection_Homo sapiens_hsa051501.39893982
30Apoptosis_Homo sapiens_hsa042101.35484157
31Malaria_Homo sapiens_hsa051441.35380634
32Acute myeloid leukemia_Homo sapiens_hsa052211.35313570
33Tuberculosis_Homo sapiens_hsa051521.34989619
34Chronic myeloid leukemia_Homo sapiens_hsa052201.29031573
35Autoimmune thyroid disease_Homo sapiens_hsa053201.28442943
36Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.24206497
37Shigellosis_Homo sapiens_hsa051311.19703172
38Non-homologous end-joining_Homo sapiens_hsa034501.19591424
39Legionellosis_Homo sapiens_hsa051341.19240455
40Pancreatic cancer_Homo sapiens_hsa052121.17570832
41Pertussis_Homo sapiens_hsa051331.16816039
42Transcriptional misregulation in cancer_Homo sapiens_hsa052021.15830792
43Platelet activation_Homo sapiens_hsa046111.13660525
44* Leukocyte transendothelial migration_Homo sapiens_hsa046701.07210020
45Epstein-Barr virus infection_Homo sapiens_hsa051691.06122654
46Asthma_Homo sapiens_hsa053101.05646836
47Viral carcinogenesis_Homo sapiens_hsa052031.00192660
48Small cell lung cancer_Homo sapiens_hsa052220.98850349
49Hepatitis C_Homo sapiens_hsa051600.98599883
50Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.97204651
51HTLV-I infection_Homo sapiens_hsa051660.92498883
52AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.90054325
53Non-small cell lung cancer_Homo sapiens_hsa052230.88692299
54DNA replication_Homo sapiens_hsa030300.86981529
55Neurotrophin signaling pathway_Homo sapiens_hsa047220.80085198
56Base excision repair_Homo sapiens_hsa034100.76772295
57Salmonella infection_Homo sapiens_hsa051320.76721392
58Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.76101366
59Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.72902905
60Systemic lupus erythematosus_Homo sapiens_hsa053220.72627014
61p53 signaling pathway_Homo sapiens_hsa041150.72387045
62Type I diabetes mellitus_Homo sapiens_hsa049400.70093085
63Colorectal cancer_Homo sapiens_hsa052100.68999886
64Prolactin signaling pathway_Homo sapiens_hsa049170.68970520
65SNARE interactions in vesicular transport_Homo sapiens_hsa041300.66084387
66Rheumatoid arthritis_Homo sapiens_hsa053230.65830949
67Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.65439690
68African trypanosomiasis_Homo sapiens_hsa051430.62498773
69Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.62336589
70FoxO signaling pathway_Homo sapiens_hsa040680.60871412
71Cell cycle_Homo sapiens_hsa041100.60516241
72Renal cell carcinoma_Homo sapiens_hsa052110.58498582
73MicroRNAs in cancer_Homo sapiens_hsa052060.57201474
74Other glycan degradation_Homo sapiens_hsa005110.57109336
75Phagosome_Homo sapiens_hsa041450.57065863
76Fanconi anemia pathway_Homo sapiens_hsa034600.57065257
77VEGF signaling pathway_Homo sapiens_hsa043700.57044161
78Phosphatidylinositol signaling system_Homo sapiens_hsa040700.56537801
79Glycosaminoglycan degradation_Homo sapiens_hsa005310.56323745
80Homologous recombination_Homo sapiens_hsa034400.54006616
81Notch signaling pathway_Homo sapiens_hsa043300.53630171
82Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.52877277
83Endometrial cancer_Homo sapiens_hsa052130.52861755
84Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.51643425
85Choline metabolism in cancer_Homo sapiens_hsa052310.49097429
86Prostate cancer_Homo sapiens_hsa052150.47967896
87Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.46317066
88Inositol phosphate metabolism_Homo sapiens_hsa005620.46186367
89* Regulation of actin cytoskeleton_Homo sapiens_hsa048100.45579872
90Mismatch repair_Homo sapiens_hsa034300.44242533
91Phospholipase D signaling pathway_Homo sapiens_hsa040720.44047700
92Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.43481225
93Sphingolipid signaling pathway_Homo sapiens_hsa040710.43007896
94Lysine degradation_Homo sapiens_hsa003100.42806192
95Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.42080565
96MAPK signaling pathway_Homo sapiens_hsa040100.41718829
97mTOR signaling pathway_Homo sapiens_hsa041500.41387998
98GnRH signaling pathway_Homo sapiens_hsa049120.40689141
99* Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.40668557
100Insulin resistance_Homo sapiens_hsa049310.40292665
101Carbohydrate digestion and absorption_Homo sapiens_hsa049730.39015090
102Spliceosome_Homo sapiens_hsa030400.38295268
103Thyroid hormone signaling pathway_Homo sapiens_hsa049190.38161695
104RNA degradation_Homo sapiens_hsa030180.37647538
105HIF-1 signaling pathway_Homo sapiens_hsa040660.36180346
106ErbB signaling pathway_Homo sapiens_hsa040120.35314181
107Lysosome_Homo sapiens_hsa041420.34364624
108Renin-angiotensin system_Homo sapiens_hsa046140.34044225
109Pathways in cancer_Homo sapiens_hsa052000.33356755
110Dorso-ventral axis formation_Homo sapiens_hsa043200.32709902
111Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.32183529
112Longevity regulating pathway - mammal_Homo sapiens_hsa042110.31771663
113Adipocytokine signaling pathway_Homo sapiens_hsa049200.31382068
114Glycerophospholipid metabolism_Homo sapiens_hsa005640.31201543
115ABC transporters_Homo sapiens_hsa020100.30950137
116Glioma_Homo sapiens_hsa052140.30890556
117Endocytosis_Homo sapiens_hsa041440.30492997
118Amoebiasis_Homo sapiens_hsa051460.30144626
119Thyroid cancer_Homo sapiens_hsa052160.26194704
120Alcoholism_Homo sapiens_hsa050340.23477388

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