ITGA6

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The gene encodes a member of the integrin alpha chain family of proteins. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain that function in cell surface adhesion and signaling. The encoded preproprotein is proteolytically processed to generate light and heavy chains that comprise the alpha 6 subunit. This subunit may associate with a beta 1 or beta 4 subunit to form an integrin that interacts with extracellular matrix proteins including members of the laminin family. The alpha 6 beta 4 integrin may promote tumorigenesis, while the alpha 6 beta 1 integrin may negatively regulate erbB2/HER2 signaling. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1* hemidesmosome assembly (GO:0031581)7.70963141
2keratinocyte proliferation (GO:0043616)6.78236694
3negative regulation of keratinocyte proliferation (GO:0010839)6.58406861
4regulation of keratinocyte proliferation (GO:0010837)5.00551472
5gap junction assembly (GO:0016264)4.78058900
6establishment of skin barrier (GO:0061436)4.77873637
7DNA damage induced protein phosphorylation (GO:0006975)4.21419988
8surfactant homeostasis (GO:0043129)4.20340679
9intermediate filament organization (GO:0045109)4.09932208
10ventricular trabecula myocardium morphogenesis (GO:0003222)4.05470049
11skin morphogenesis (GO:0043589)4.02781490
12desmosome organization (GO:0002934)4.01609488
13bundle of His cell to Purkinje myocyte communication (GO:0086069)3.99746714
14* cell-substrate junction assembly (GO:0007044)3.87612634
15regulation of hair follicle development (GO:0051797)3.86262861
16artery development (GO:0060840)3.73196884
17epidermis development (GO:0008544)3.69764063
18regulation of telomere maintenance via telomerase (GO:0032210)3.59157001
19basement membrane organization (GO:0071711)3.57455119
20regulation of cardioblast differentiation (GO:0051890)3.52742271
21regulation of integrin activation (GO:0033623)3.50796304
22negative regulation of anoikis (GO:2000811)3.43755579
23chemical homeostasis within a tissue (GO:0048875)3.42440826
24negative regulation of telomerase activity (GO:0051974)3.42075345
25negative regulation of cardiac muscle cell apoptotic process (GO:0010667)3.39691858
26mammary gland development (GO:0030879)3.34495673
27lateral sprouting from an epithelium (GO:0060601)3.30327542
28* cell junction assembly (GO:0034329)3.24889940
29keratinocyte development (GO:0003334)3.23502172
30cellular response to vitamin D (GO:0071305)3.20684802
31mesodermal cell differentiation (GO:0048333)3.19061252
32regulation of SMAD protein import into nucleus (GO:0060390)3.18041501
33atrioventricular valve morphogenesis (GO:0003181)3.16255097
34apoptotic cell clearance (GO:0043277)3.15606410
35establishment of planar polarity (GO:0001736)3.13657005
36establishment of tissue polarity (GO:0007164)3.13657005
37focal adhesion assembly (GO:0048041)3.12879988
38cell-substrate adherens junction assembly (GO:0007045)3.12879988
39telomere maintenance via telomerase (GO:0007004)3.12513368
40keratinization (GO:0031424)3.09244363
41heart trabecula morphogenesis (GO:0061384)3.08807772
42regulation of transforming growth factor beta2 production (GO:0032909)3.08370608
43positive regulation of epidermis development (GO:0045684)3.07638358
44positive regulation of SMAD protein import into nucleus (GO:0060391)3.05562465
45lymphangiogenesis (GO:0001946)3.04230136
46molting cycle (GO:0042303)3.03588878
47hair cycle (GO:0042633)3.03588878
48definitive hemopoiesis (GO:0060216)3.00605772
49epithelial cell-cell adhesion (GO:0090136)2.99293229
50planar cell polarity pathway involved in neural tube closure (GO:0090179)2.99274452
51plasma membrane repair (GO:0001778)2.99231764
52gland morphogenesis (GO:0022612)2.99175255
53multicellular organismal water homeostasis (GO:0050891)2.94774426
54wound healing (GO:0042060)2.94529749
55positive regulation of p38MAPK cascade (GO:1900745)2.94198182
56paraxial mesoderm development (GO:0048339)2.91581901
57ventricular cardiac muscle cell action potential (GO:0086005)2.88541797
58dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.88215995
59growth hormone receptor signaling pathway (GO:0060396)2.87779164
60antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.87681883
61negative regulation of protein localization to cell surface (GO:2000009)2.86509118
62extracellular matrix disassembly (GO:0022617)2.85634987
63substrate adhesion-dependent cell spreading (GO:0034446)2.85477884
64regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.85173584
65vascular endothelial growth factor signaling pathway (GO:0038084)2.83473271
66regulation of epidermis development (GO:0045682)2.81918504
67substrate-dependent cell migration (GO:0006929)2.79371749
68branching involved in mammary gland duct morphogenesis (GO:0060444)2.76207901
69* renal system development (GO:0072001)2.75459325
70renal filtration (GO:0097205)2.74406449
71regulation of epidermal growth factor-activated receptor activity (GO:0007176)2.73801312
72regulation of anoikis (GO:2000209)2.73720649
73membrane protein ectodomain proteolysis (GO:0006509)2.73552367
74regulation of transforming growth factor beta production (GO:0071634)2.73387916
75L-serine transport (GO:0015825)2.73009892
76negative regulation of granulocyte differentiation (GO:0030853)2.71464988
77regulation of Wnt signaling pathway involved in heart development (GO:0003307)2.69007669
78endodermal cell differentiation (GO:0035987)2.68818803
79retina vasculature morphogenesis in camera-type eye (GO:0061299)2.68470073
80RNA-dependent DNA replication (GO:0006278)2.67506086
81epidermal cell differentiation (GO:0009913)2.67267916
82hippo signaling (GO:0035329)2.67026653
83negative regulation of cartilage development (GO:0061037)2.65709322
84cellular response to vitamin (GO:0071295)2.65629265
85chondrocyte proliferation (GO:0035988)2.62579041
86regulation of hair cycle (GO:0042634)2.62252152
87regulation of keratinocyte differentiation (GO:0045616)2.62198119
88positive regulation of hair cycle (GO:0042635)2.62103189
89positive regulation of hair follicle development (GO:0051798)2.62103189
90intestinal epithelial cell development (GO:0060576)2.61653893
91semaphorin-plexin signaling pathway (GO:0071526)2.61299936
92intermediate filament cytoskeleton organization (GO:0045104)2.60907428
93negative regulation of epidermis development (GO:0045683)2.60524661
94cell migration involved in sprouting angiogenesis (GO:0002042)2.60119468
95endothelial cell differentiation (GO:0045446)2.57320279
96negative regulation of cell fate specification (GO:0009996)2.57037470
97regulation of branching involved in salivary gland morphogenesis (GO:0060693)2.55151150
98negative regulation of smooth muscle cell migration (GO:0014912)2.54060124
99fibroblast migration (GO:0010761)2.54011089
100intermediate filament-based process (GO:0045103)2.53915706
101cell surface receptor signaling pathway involved in heart development (GO:0061311)2.52775536
102mammary gland epithelial cell proliferation (GO:0033598)2.50950961
103mitotic G1 DNA damage checkpoint (GO:0031571)2.50462899
104cellular response to growth hormone stimulus (GO:0071378)2.50165046
105adherens junction organization (GO:0034332)2.47999417
106lymph vessel development (GO:0001945)2.47920340
107regulation of transforming growth factor beta1 production (GO:0032908)2.47814687
108germ cell migration (GO:0008354)2.47787475
109regulation of helicase activity (GO:0051095)2.47679440
110regulation of p38MAPK cascade (GO:1900744)2.46187229
111regulation of hippo signaling (GO:0035330)2.45401446
112cellular response to vascular endothelial growth factor stimulus (GO:0035924)2.44561437
113Notch signaling involved in heart development (GO:0061314)2.43943896
114endothelial tube morphogenesis (GO:0061154)2.42625144
115morphogenesis of an endothelium (GO:0003159)2.42625144
116regulation of cell proliferation involved in heart morphogenesis (GO:2000136)2.42120841
117branching involved in salivary gland morphogenesis (GO:0060445)2.41579475
118positive regulation of keratinocyte differentiation (GO:0045618)2.41146485
119negative regulation of stress fiber assembly (GO:0051497)2.39191858
120apoptotic process involved in morphogenesis (GO:0060561)2.38622663
121positive regulation of epithelial to mesenchymal transition (GO:0010718)2.38315629
122trabecula morphogenesis (GO:0061383)2.38215798
123polarized epithelial cell differentiation (GO:0030859)2.36727001
124regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition 2.36416888
125endothelial cell chemotaxis (GO:0035767)2.35059268
126coronary vasculature morphogenesis (GO:0060977)2.33376378
127embryonic process involved in female pregnancy (GO:0060136)2.32703160
128regulation of heart morphogenesis (GO:2000826)2.31169780
129radial glial cell differentiation (GO:0060019)2.29691273
130cytoskeletal anchoring at plasma membrane (GO:0007016)2.29456746
131glomerular filtration (GO:0003094)2.29221926
132cardiac right ventricle morphogenesis (GO:0003215)2.28364888
133heart valve morphogenesis (GO:0003179)2.28122806
134regulation of cell fate specification (GO:0042659)2.27908353
135cardiac epithelial to mesenchymal transition (GO:0060317)2.27531506
136regulation of chemokine secretion (GO:0090196)2.27229557
137trophectodermal cell differentiation (GO:0001829)2.27151067
138embryonic foregut morphogenesis (GO:0048617)2.25609778
139endothelial cell morphogenesis (GO:0001886)2.25501052
140morphogenesis of an epithelial sheet (GO:0002011)2.23421272
141hepatocyte apoptotic process (GO:0097284)2.22300760
142endocardial cushion development (GO:0003197)2.21688787
143embryonic camera-type eye morphogenesis (GO:0048596)2.20880786
144positive regulation of epidermal cell differentiation (GO:0045606)2.20508407
145wound healing, spreading of epidermal cells (GO:0035313)2.19371441
146mRNA transcription (GO:0009299)2.18830686
147somatic stem cell division (GO:0048103)2.16956768
148blood vessel endothelial cell migration (GO:0043534)2.16931476
149* cell adhesion mediated by integrin (GO:0033627)2.16931241
150ectoderm development (GO:0007398)2.16357683
151adherens junction assembly (GO:0034333)2.15500139
152positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.15373314
153pinocytosis (GO:0006907)2.14100675
154pathway-restricted SMAD protein phosphorylation (GO:0060389)2.13767214
155establishment of epithelial cell polarity (GO:0090162)2.12849373
156epithelial cell differentiation involved in prostate gland development (GO:0060742)2.12301783
157protein localization to endosome (GO:0036010)2.12119932
158establishment of apical/basal cell polarity (GO:0035089)2.11491246
159regulation of water loss via skin (GO:0033561)2.07835091
160regulation of glial cell proliferation (GO:0060251)2.05803886
161keratinocyte differentiation (GO:0030216)2.05061616
162notochord development (GO:0030903)2.04970799
163positive regulation of stem cell differentiation (GO:2000738)2.03251591
164positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003602.02733552
165cellular response to interferon-alpha (GO:0035457)2.02671475
166negative regulation of chondrocyte differentiation (GO:0032331)2.02535115
167hypotonic response (GO:0006971)2.02429621
168regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.02336163
169aorta morphogenesis (GO:0035909)2.01949936
170platelet-derived growth factor receptor signaling pathway (GO:0048008)2.01935658
171insulin-like growth factor receptor signaling pathway (GO:0048009)2.01755655
172* cell junction organization (GO:0034330)2.01588177

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* TP63_17297297_ChIP-ChIP_HaCaT_Human8.66702325
2* NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.49302175
3TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse3.38891738
4EGR1_19374776_ChIP-ChIP_THP-1_Human3.21931988
5BP1_19119308_ChIP-ChIP_Hs578T_Human3.00854770
6TRIM28_21343339_ChIP-Seq_HEK293_Human2.88217772
7SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.79318433
8HIF1A_21447827_ChIP-Seq_MCF-7_Human2.43761417
9ESR1_21235772_ChIP-Seq_MCF-7_Human2.36976222
10SMAD3_18955504_ChIP-ChIP_HaCaT_Human2.07767686
11SMAD2_18955504_ChIP-ChIP_HaCaT_Human2.07767686
12FOXM1_23109430_ChIP-Seq_U2OS_Human2.06441828
13STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.03819011
14* SOX9_24532713_ChIP-Seq_HFSC_Mouse2.03346878
15RARG_19884340_ChIP-ChIP_MEFs_Mouse2.01827401
16* CLOCK_20551151_ChIP-Seq_293T_Human1.99662034
17KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.98150876
18FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.97866470
19ZNF263_19887448_ChIP-Seq_K562_Human1.94226873
20* FOXO3_23340844_ChIP-Seq_DLD1_Human1.93694835
21E2F7_22180533_ChIP-Seq_HELA_Human1.87316469
22STAT6_21828071_ChIP-Seq_BEAS2B_Human1.83061980
23ESR2_21235772_ChIP-Seq_MCF-7_Human1.81354874
24STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.76731106
25TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.74764982
26GATA2_21666600_ChIP-Seq_HMVEC_Human1.73660102
27* PPAR_26484153_Chip-Seq_NCI-H1993_Human1.72035833
28* TP63_23658742_ChIP-Seq_EP156T_Human1.68195136
29NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.64087162
30ELK3_25401928_ChIP-Seq_HUVEC_Human1.61939573
31SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.60784938
32KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.58183170
33KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.58183170
34KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.58183170
35AR_21909140_ChIP-Seq_LNCAP_Human1.55419690
36* CJUN_26792858_Chip-Seq_BT549_Human1.53436458
37TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.49033955
38ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.48073416
39KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.47645687
40* ZNF217_24962896_ChIP-Seq_MCF-7_Human1.45364604
41CDX2_20551321_ChIP-Seq_CACO-2_Human1.45178179
42SALL1_21062744_ChIP-ChIP_HESCs_Human1.42282778
43RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.41781149
44SOX2_20726797_ChIP-Seq_SW620_Human1.41401936
45EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.41356830
46TCF7_22412390_ChIP-Seq_EML_Mouse1.41190725
47TCF3_18692474_ChIP-Seq_MEFs_Mouse1.40631419
48STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.38697138
49FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.36319032
50RUNX1_27514584_Chip-Seq_MCF-7_Human1.35501416
51GATA6_25053715_ChIP-Seq_YYC3_Human1.35185066
52POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.35047858
53* TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.34671226
54P63_26484246_Chip-Seq_KERATINOCYTES_Human1.34196047
55EP300_21415370_ChIP-Seq_HL-1_Mouse1.33478488
56STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.33200483
57ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.33181184
58ESR1_20079471_ChIP-ChIP_T-47D_Human1.32874930
59TBX20_22328084_ChIP-Seq_HEART_Mouse1.32388265
60TBX20_22080862_ChIP-Seq_HEART_Mouse1.32388265
61RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.32294374
62UBF1/2_26484160_Chip-Seq_HMECs_Human1.31131086
63SALL4_18804426_ChIP-ChIP_XEN_Mouse1.31047673
64SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.29361628
65BRD4_25478319_ChIP-Seq_HGPS_Human1.29222098
66ATF3_27146783_Chip-Seq_COLON_Human1.28070222
67FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.27317901
68SCL_19346495_ChIP-Seq_HPC-7_Human1.27035952
69SOX2_27498859_Chip-Seq_STOMACH_Mouse1.25901524
70* ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.24968041
71RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.23975321
72RACK7_27058665_Chip-Seq_MCF-7_Human1.23745908
73* TP53_18474530_ChIP-ChIP_U2OS_Human1.23714007
74PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.23017715
75CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.20765540
76UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.20354222
77TP53_16413492_ChIP-PET_HCT116_Human1.20160859
78KDM2B_26808549_Chip-Seq_SUP-B15_Human1.18832309
79SMAD_19615063_ChIP-ChIP_OVARY_Human1.18334819
80SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.18166257
81MYB_21317192_ChIP-Seq_ERMYB_Mouse1.18100215
82NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.17465519
83* GATA4_25053715_ChIP-Seq_YYC3_Human1.16959980
84NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.16037995
85SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.15034185
86NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.13450230
87WT1_19549856_ChIP-ChIP_CCG9911_Human1.13371944
88ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.12250261
89EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.11524945
90P300_27058665_Chip-Seq_ZR-75-30cells_Human1.10637881
91* TCF4_18268006_ChIP-ChIP_LS174T_Human1.10362596
92CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.09274612
93NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.07884643
94* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.07538877
95* KLF5_25053715_ChIP-Seq_YYC3_Human1.06821587
96* JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.06226887
97BRD4_27068464_Chip-Seq_AML-cells_Mouse1.05163643
98AHR_22903824_ChIP-Seq_MCF-7_Human1.04360573
99PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.03990693
100KDM2B_26808549_Chip-Seq_DND41_Human1.03599744
101IRF8_27001747_Chip-Seq_BMDM_Mouse1.00689825
102MYC_22102868_ChIP-Seq_BL_Human0.99463641
103Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.98690861
104CTNNB1_20460455_ChIP-Seq_HCT116_Human0.97895905
105ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.97759221
106ISL1_27105846_Chip-Seq_CPCs_Mouse0.97605176
107* JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.95797981
108TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.95794306
109* RUNX_20019798_ChIP-Seq_JUKART_Human0.95694032
110HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.94581297
111WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.93426907
112CDX2_19796622_ChIP-Seq_MESCs_Mouse0.92236646
113* TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.90825705
114GATA3_24758297_ChIP-Seq_MCF-7_Human0.89916872
115KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.86126838
116TP63_22573176_ChIP-Seq_HFKS_Human0.84386686
117ELK4_26923725_Chip-Seq_MESODERM_Mouse0.83976895
118ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.83926081
119PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.79220863
120* ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.78532078
121GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.77089359
122ARNT_22903824_ChIP-Seq_MCF-7_Human0.76760950
123TCF3_18692474_ChIP-Seq_MESCs_Mouse0.75519053
124CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.73731444
125* NANOG_18692474_ChIP-Seq_MEFs_Mouse0.73425329
126TP53_22127205_ChIP-Seq_IMR90_Human0.72225733
127* SMAD3_21741376_ChIP-Seq_HESCs_Human0.71343729
128* FOXA2_19822575_ChIP-Seq_HepG2_Human0.71080760
129KLF4_18555785_ChIP-Seq_MESCs_Mouse0.69960568
130RXR_22108803_ChIP-Seq_LS180_Human0.69729249

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010234_abnormal_vibrissa_follicle3.34297041
2* MP0004272_abnormal_basement_membrane2.98323544
3MP0002254_reproductive_system_inflammat2.88433930
4MP0003705_abnormal_hypodermis_morpholog2.87827500
5MP0003566_abnormal_cell_adhesion2.62466751
6MP0010352_gastrointestinal_tract_polyps2.58443932
7MP0005409_darkened_coat_color2.56720947
8MP0003828_pulmonary_edema2.30447059
9MP0003941_abnormal_skin_development2.20786350
10MP0003300_gastrointestinal_ulcer2.13388762
11MP0000383_abnormal_hair_follicle2.12439746
12MP0010678_abnormal_skin_adnexa2.10271786
13MP0005076_abnormal_cell_differentiation1.89503774
14MP0001849_ear_inflammation1.89474659
15MP0003453_abnormal_keratinocyte_physiol1.85024006
16MP0002234_abnormal_pharynx_morphology1.84333072
17MP0005275_abnormal_skin_tensile1.84100040
18MP0002796_impaired_skin_barrier1.82682867
19MP0005257_abnormal_intraocular_pressure1.77902407
20MP0002060_abnormal_skin_morphology1.76857326
21MP0003045_fibrosis1.74073707
22MP0009278_abnormal_bone_marrow1.73143285
23MP0005360_urolithiasis1.63957503
24MP0008438_abnormal_cutaneous_collagen1.61451585
25MP0001879_abnormal_lymphatic_vessel1.55288237
26MP0002877_abnormal_melanocyte_morpholog1.55171790
27MP0000537_abnormal_urethra_morphology1.52266207
28MP0005023_abnormal_wound_healing1.51578703
29MP0004084_abnormal_cardiac_muscle1.49958129
30MP0001216_abnormal_epidermal_layer1.44727836
31MP0010368_abnormal_lymphatic_system1.41203979
32MP0009384_cardiac_valve_regurgitation1.39804372
33MP0006054_spinal_hemorrhage1.39637624
34MP0003567_abnormal_fetal_cardiomyocyte1.39235956
35MP0003950_abnormal_plasma_membrane1.37215682
36MP0005623_abnormal_meninges_morphology1.36802694
37MP0002166_altered_tumor_susceptibility1.36624266
38MP0002009_preneoplasia1.33734906
39MP0002098_abnormal_vibrissa_morphology1.32997899
40MP0000733_abnormal_muscle_development1.32088275
41MP0000516_abnormal_urinary_system1.32010610
42MP0005367_renal/urinary_system_phenotyp1.32010610
43MP0004185_abnormal_adipocyte_glucose1.29881930
44MP0010630_abnormal_cardiac_muscle1.28376518
45MP0000678_abnormal_parathyroid_gland1.28058883
46MP0003191_abnormal_cellular_cholesterol1.26709322
47MP0000767_abnormal_smooth_muscle1.24523052
48MP0004782_abnormal_surfactant_physiolog1.22689093
49MP0004264_abnormal_extraembryonic_tissu1.18440781
50MP0000377_abnormal_hair_follicle1.18191793
51MP0003091_abnormal_cell_migration1.17752533
52MP0008260_abnormal_autophagy1.16284599
53MP0005501_abnormal_skin_physiology1.14499230
54MP0001851_eye_inflammation1.14383487
55MP0004947_skin_inflammation1.14308343
56MP0002396_abnormal_hematopoietic_system1.12087420
57MP0000467_abnormal_esophagus_morphology1.10656056
58MP0000762_abnormal_tongue_morphology1.09534908
59MP0002089_abnormal_postnatal_growth/wei1.07465991
60MP0010030_abnormal_orbit_morphology1.06768980
61* MP0002925_abnormal_cardiovascular_devel1.06163611
62MP0002896_abnormal_bone_mineralization1.05199119
63MP0009780_abnormal_chondrocyte_physiolo1.04573520
64MP0000627_abnormal_mammary_gland1.03750546
65MP0001873_stomach_inflammation1.02207479
66MP0001915_intracranial_hemorrhage1.02024554
67MP0002006_tumorigenesis1.01379233
68MP0005167_abnormal_blood-brain_barrier1.01037868
69MP0003279_aneurysm1.00660206
70MP0000750_abnormal_muscle_regeneration1.00493717
71MP0009053_abnormal_anal_canal1.00062724
72MP0000566_synostosis0.99351026
73MP0004808_abnormal_hematopoietic_stem0.98666929
74MP0002086_abnormal_extraembryonic_tissu0.98643958
75MP0006138_congestive_heart_failure0.98013216
76MP0003755_abnormal_palate_morphology0.97677451
77MP0000465_gastrointestinal_hemorrhage0.95791440
78MP0005197_abnormal_uvea_morphology0.95051151
79MP0010307_abnormal_tumor_latency0.90971516
80MP0000490_abnormal_crypts_of0.90967955
81MP0001299_abnormal_eye_distance/0.90960363
82MP0003724_increased_susceptibility_to0.89222309
83MP0005666_abnormal_adipose_tissue0.89182031
84MP0010771_integument_phenotype0.89154154
85MP0000427_abnormal_hair_cycle0.87902220
86MP0004381_abnormal_hair_follicle0.85542757
87MP0001346_abnormal_lacrimal_gland0.85459836
88MP0000579_abnormal_nail_morphology0.84374984
89MP0005397_hematopoietic_system_phenotyp0.84007641
90MP0001545_abnormal_hematopoietic_system0.84007641
91MP0000858_altered_metastatic_potential0.83975965
92MP0004484_altered_response_of0.83787909
93* MP0001614_abnormal_blood_vessel0.82880463
94* MP0001191_abnormal_skin_condition0.82601831
95MP0000367_abnormal_coat/_hair0.82197042
96MP0010155_abnormal_intestine_physiology0.82150135
97MP0003878_abnormal_ear_physiology0.81815035
98MP0005377_hearing/vestibular/ear_phenot0.81815035
99MP0002088_abnormal_embryonic_growth/wei0.80671527
100MP0004858_abnormal_nervous_system0.80602475
101MP0003984_embryonic_growth_retardation0.78702722
102MP0002128_abnormal_blood_circulation0.77673495
103MP0001784_abnormal_fluid_regulation0.76852841
104MP0000343_altered_response_to0.76374020
105* MP0000432_abnormal_head_morphology0.76030209
106MP0005670_abnormal_white_adipose0.75504105
107MP0002111_abnormal_tail_morphology0.75484452
108MP0004087_abnormal_muscle_fiber0.75385258
109MP0005595_abnormal_vascular_smooth0.75289874
110MP0002697_abnormal_eye_size0.75064407
111MP0000647_abnormal_sebaceous_gland0.75053827
112MP0001544_abnormal_cardiovascular_syste0.74528550
113MP0005385_cardiovascular_system_phenoty0.74528550
114MP0003315_abnormal_perineum_morphology0.73954696
115MP0000428_abnormal_craniofacial_morphol0.73871353
116MP0001881_abnormal_mammary_gland0.73409126
117MP0005330_cardiomyopathy0.72941397
118MP0009931_abnormal_skin_appearance0.72810655
119MP0002168_other_aberrant_phenotype0.72546699
120MP0003385_abnormal_body_wall0.72423153
121MP0003935_abnormal_craniofacial_develop0.72343682
122MP0002233_abnormal_nose_morphology0.72158592
123MP0000266_abnormal_heart_morphology0.71251260
124MP0002972_abnormal_cardiac_muscle0.71134505
125* MP0003448_altered_tumor_morphology0.71073653
126MP0005248_abnormal_Harderian_gland0.70961236
127MP0005380_embryogenesis_phenotype0.70497319
128MP0001672_abnormal_embryogenesis/_devel0.70497319
129MP0004957_abnormal_blastocyst_morpholog0.70309646
130MP0000462_abnormal_digestive_system0.68363928
131MP0005164_abnormal_response_to0.64360634
132MP0008932_abnormal_embryonic_tissue0.64154446
133MP0001243_abnormal_dermal_layer0.64055899
134MP0001340_abnormal_eyelid_morphology0.62810462
135MP0002282_abnormal_trachea_morphology0.62560404
136MP0008789_abnormal_olfactory_epithelium0.62266525
137MP0005621_abnormal_cell_physiology0.61967875
138MP0004197_abnormal_fetal_growth/weight/0.60464560
139MP0009672_abnormal_birth_weight0.60333316
140MP0002084_abnormal_developmental_patter0.59818810
141MP0002177_abnormal_outer_ear0.56850222
142MP0004270_analgesia0.56589979
143MP0005165_increased_susceptibility_to0.54490545
144MP0005193_abnormal_anterior_eye0.54403152
145MP0009697_abnormal_copulation0.53877034
146MP0000538_abnormal_urinary_bladder0.53349012

Predicted human phenotypes

RankGene SetZ-score
1* Milia (HP:0001056)4.92007328
2Onycholysis (HP:0001806)4.42031308
3* Atrophic scars (HP:0001075)4.13008823
4Right ventricular cardiomyopathy (HP:0011663)4.07847750
5Fragile nails (HP:0001808)3.74340957
6Hematochezia (HP:0002573)3.64833140
7Cerebral aneurysm (HP:0004944)3.62352704
8Plantar hyperkeratosis (HP:0007556)3.54264804
9Ankyloglossia (HP:0010296)3.50676665
10Ulnar claw (HP:0001178)3.43262610
11Abnormal hair laboratory examination (HP:0003328)3.18356990
12* Pterygium (HP:0001059)3.18350217
13Thick nail (HP:0001805)3.07808470
14Back pain (HP:0003418)3.03320445
15Amniotic constriction ring (HP:0009775)3.01336684
16Abnormality of placental membranes (HP:0011409)3.01336684
17Sparse scalp hair (HP:0002209)2.97557973
18Alopecia of scalp (HP:0002293)2.92980442
19Abnormality of oral frenula (HP:0000190)2.82561202
20Rectal prolapse (HP:0002035)2.80345667
21Popliteal pterygium (HP:0009756)2.78977288
22Ventricular tachycardia (HP:0004756)2.76233124
23Segmental peripheral demyelination/remyelination (HP:0003481)2.73697377
24Increased connective tissue (HP:0009025)2.71955112
25Shallow orbits (HP:0000586)2.67704935
26Oral leukoplakia (HP:0002745)2.67179732
27Sparse eyelashes (HP:0000653)2.61878060
28Subacute progressive viral hepatitis (HP:0006572)2.53101451
29Abnormality of the nasal septum (HP:0000419)2.51331801
30Dry hair (HP:0011359)2.49558567
31Hypoplastic labia majora (HP:0000059)2.49053081
32Short nail (HP:0001799)2.43960706
33Osteolytic defects of the hand bones (HP:0009699)2.41952836
34Osteolytic defects of the phalanges of the hand (HP:0009771)2.41952836
35Aortic aneurysm (HP:0004942)2.41251431
36Pili torti (HP:0003777)2.40897992
37* Nail dystrophy (HP:0008404)2.40834623
38Urethral obstruction (HP:0000796)2.37436332
39Abnormality of the salivary glands (HP:0010286)2.36159230
40* Anonychia (HP:0001798)2.35401326
41Abnormality of the neuromuscular junction (HP:0003398)2.33484702
42Fatigable weakness (HP:0003473)2.33484702
43Abnormality of the labia majora (HP:0012881)2.32394515
44Ankle contracture (HP:0006466)2.31136242
45Absent eyelashes (HP:0000561)2.28433518
46Aortic dissection (HP:0002647)2.26657144
47Lip pit (HP:0100267)2.24545030
48* Aplasia cutis congenita (HP:0001057)2.23679097
49Arterial tortuosity (HP:0005116)2.23191131
50Woolly hair (HP:0002224)2.22146555
51Palmoplantar hyperkeratosis (HP:0000972)2.21367778
52Abnormality of secondary sexual hair (HP:0009888)2.19757336
53Abnormality of the axillary hair (HP:0100134)2.19757336
54Carious teeth (HP:0000670)2.18074544
55Blepharitis (HP:0000498)2.16223545
56Palmar hyperkeratosis (HP:0010765)2.15942621
57Breast hypoplasia (HP:0003187)2.15016508
58Asymmetry of the thorax (HP:0001555)2.12101349
59* Fragile skin (HP:0001030)2.09385482
60Cervical subluxation (HP:0003308)2.08659330
61Curly hair (HP:0002212)2.07440789
62Hypodontia (HP:0000668)2.06621158
63Vertebral arch anomaly (HP:0008438)2.05660371
64Mitral valve prolapse (HP:0001634)2.05464840
65Enlarged penis (HP:0000040)2.04203656
66Bicuspid aortic valve (HP:0001647)2.00217392
67Skull defect (HP:0001362)1.99765955
68Distal lower limb muscle weakness (HP:0009053)1.98120316
69Germ cell neoplasia (HP:0100728)1.97166869
70Broad face (HP:0000283)1.94750510
71Vascular tortuosity (HP:0004948)1.94386386
72Palmoplantar keratoderma (HP:0000982)1.92578482
73Esophageal varix (HP:0002040)1.90697439
74Trismus (HP:0000211)1.90496755
75Corneal erosion (HP:0200020)1.90453856
76Aneurysm (HP:0002617)1.89722418
77Malignant gastrointestinal tract tumors (HP:0006749)1.89195770
78Gastrointestinal carcinoma (HP:0002672)1.89195770
79Hyporeflexia of lower limbs (HP:0002600)1.88954442
80Neurofibrillary tangles (HP:0002185)1.88651164
81Abnormal vertebral ossification (HP:0100569)1.87945384
82Increased CSF protein (HP:0002922)1.87783203
83* Hypoplasia of dental enamel (HP:0006297)1.86978257
84Abnormality of the gastric mucosa (HP:0004295)1.86817732
85Xerostomia (HP:0000217)1.85056741
86Selective tooth agenesis (HP:0001592)1.82589012
87Protrusio acetabuli (HP:0003179)1.81451716
88Hyperhidrosis (HP:0000975)1.79388778
89Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.78983789
90Follicular hyperkeratosis (HP:0007502)1.76633405
91Abnormality of the fingernails (HP:0001231)1.76341106
92Deviation of the thumb (HP:0009603)1.75924912
93Pustule (HP:0200039)1.75593042
94Hypotrichosis (HP:0001006)1.74472963
95Vascular calcification (HP:0004934)1.74043737
96Abnormality of carpal bone ossification (HP:0006257)1.73915981
97Flat acetabular roof (HP:0003180)1.73482019
98Thin bony cortex (HP:0002753)1.73380900
99* Abnormal blistering of the skin (HP:0008066)1.72908566
100Systemic lupus erythematosus (HP:0002725)1.71812908
101Premature rupture of membranes (HP:0001788)1.71477647
102Biliary tract neoplasm (HP:0100574)1.71129007
103Neonatal death (HP:0003811)1.69972687
104Laryngomalacia (HP:0001601)1.69392994
105Micronodular cirrhosis (HP:0001413)1.67513049
106Upper limb muscle weakness (HP:0003484)1.67375411
107Uterine neoplasm (HP:0010784)1.67256007
108Advanced eruption of teeth (HP:0006288)1.67107536
109Hypoplastic ischia (HP:0003175)1.66939412
110Ridged nail (HP:0001807)1.65363531
111Cerebral inclusion bodies (HP:0100314)1.65331615
112Acanthosis nigricans (HP:0000956)1.65255626
113Cardiovascular calcification (HP:0011915)1.65177663
114Premature loss of primary teeth (HP:0006323)1.64976629
115Aplasia/Hypoplasia of the vertebrae (HP:0008515)1.63610852
116Vertebral hypoplasia (HP:0008417)1.63610852
117Broad metatarsal (HP:0001783)1.62271451
118Cheilitis (HP:0100825)1.61221679
119Hoarse voice (HP:0001609)1.59852494
120Mesangial abnormality (HP:0001966)1.59761889
121Aplasia involving bones of the upper limbs (HP:0009823)1.58460391
122Aplasia of the phalanges of the hand (HP:0009802)1.58460391
123Aplasia involving bones of the extremities (HP:0009825)1.58460391
124Freckling (HP:0001480)1.58101672
125Abnormality of permanent molar morphology (HP:0011071)1.57887432
126Abnormality of the dental root (HP:0006486)1.57887432
127Taurodontia (HP:0000679)1.57887432
128Vertebral clefting (HP:0008428)1.56794502
129Spondylolisthesis (HP:0003302)1.56215858
130Tibial bowing (HP:0002982)1.56208542
131Adactyly (HP:0009776)1.56067021
132Spinal rigidity (HP:0003306)1.54756876
133Dehydration (HP:0001944)1.54457205
134Wrist flexion contracture (HP:0001239)1.54085907
135Epidermoid cyst (HP:0200040)1.54073626
136Lipoatrophy (HP:0100578)1.53331625
137Periodontitis (HP:0000704)1.52917244
138Natal tooth (HP:0000695)1.52493949
139Portal hypertension (HP:0001409)1.52470319
140Scapular winging (HP:0003691)1.52422464
141Erythema (HP:0010783)1.51886317
142Lymphangioma (HP:0100764)1.51746966
143Transitional cell carcinoma of the bladder (HP:0006740)1.50631301
144Abnormality of the ischium (HP:0003174)1.49931089
145Colon cancer (HP:0003003)1.47730120
146Abnormality of nail color (HP:0100643)1.47562963
147Radial bowing (HP:0002986)1.46868740
148Abnormality of the distal phalanx of the thumb (HP:0009617)1.45865675
149Reticulocytopenia (HP:0001896)1.44326929
150Difficulty climbing stairs (HP:0003551)1.42165031
151Abnormality of the fingertips (HP:0001211)1.42161151
152Bladder carcinoma (HP:0002862)1.42028681
153Bladder neoplasm (HP:0009725)1.42028681
154Abnormality of the distal phalanges of the toes (HP:0010182)1.41869844
155Arterial thrombosis (HP:0004420)1.41347403
156Oligodontia (HP:0000677)1.40863383

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TAOK25.68443989
2EPHA23.14427895
3PKN23.06379745
4TGFBR22.98367844
5TIE12.59042528
6TRIB32.52826655
7LATS12.52205420
8MAP2K62.44408259
9FRK2.42650951
10RIPK12.37521095
11ARAF2.29814272
12PTK62.28943850
13EPHB12.21896671
14TTN2.17517581
15NTRK12.16400195
16EEF2K2.11529428
17MST1R2.06761782
18CAMK1D2.03300796
19STK101.97471260
20MAP3K31.92779477
21LATS21.90751787
22CDK121.88676627
23TGFBR11.79600627
24PAK41.75993078
25EPHB21.70302278
26FGFR31.67799299
27RPS6KB21.58505620
28LRRK21.56534143
29MAP3K51.56309917
30KSR21.54596965
31FER1.53572271
32DMPK1.53277891
33CDK61.44741386
34STK31.43231403
35TRPM71.38469324
36MET1.36751710
37MAPKAPK31.27661039
38MAP2K21.26646046
39LMTK21.26052463
40MST41.24101410
41KDR1.20244018
42PTK21.16311446
43MAP2K31.13201483
44PDGFRA1.12986721
45CAMK1G1.09639326
46MAP3K91.07241505
47FGFR21.05102239
48ZAK1.04816532
49PIM21.04060424
50TLK10.98457342
51STK240.96324657
52JAK30.95512045
53ERN10.94965417
54CHUK0.94871457
55PAK20.94778835
56KSR10.94378912
57ERBB40.92092675
58RPS6KA40.91086171
59FLT30.90442009
60EPHA30.87715004
61TYK20.87162968
62CDK90.86014051
63BMX0.85736636
64IRAK30.85255206
65PDGFRB0.84546072
66SMG10.83213541
67MTOR0.82283292
68OBSCN0.82041790
69NLK0.81536274
70MKNK10.81129691
71NUAK10.80389433
72SIK10.80122263
73ERBB20.77432015
74PBK0.75455183
75FGFR10.73841731
76FGFR40.72975107
77RAF10.72536570
78MAP3K100.72272048
79BRAF0.71907246
80MOS0.71548883
81PRKG20.71302082
82MATK0.67465902
83PIK3CA0.63683201
84NEK90.62155451
85MAP3K80.61772667
86MELK0.61766750
87RET0.61491423
88STK390.59543708
89STK38L0.57514679
90CDK40.57275100
91GSK3A0.56872948
92PRKAA20.55187010
93ROCK20.54372379
94CSK0.53714603
95ICK0.52819329
96DDR20.52370236
97ILK0.51967370
98CSF1R0.51909229
99NEK20.51075827
100MAPK150.51025049
101STK40.49257367
102IGF1R0.49031924
103STK380.48758622
104DYRK1B0.47378550
105MAP3K60.47124625
106MAPKAPK20.46963841
107SCYL20.46647907
108AURKB0.46527898
109MAP3K20.46501781
110PDK20.45525775
111PTK2B0.44871295
112PIM10.44737203
113EGFR0.44405331
114WNK10.44039803
115MAP3K120.43758833
116SGK30.43714249
117ZAP700.43603029
118TSSK60.43275731
119KIT0.42593122
120RPS6KA20.42133261
121PRKD10.41084766
122TTK0.40436108
123BCR0.37932937
124BRSK20.37795816
125JAK10.37565656
126BTK0.36292583
127IKBKB0.35730259
128CDK70.35138962
129MAP2K10.34552694
130MAP3K70.31164999
131CDK80.28981133
132ROCK10.28926404
133PRKCI0.27458570
134SIK30.26655108
135PRPF4B0.25205428
136NME10.20236368
137ERBB30.19219650
138CDC42BPA0.18007650
139MAPKAPK50.17017125
140INSR0.15537431
141MAP3K10.15137989
142FGR0.15121362
143EIF2AK20.15067140
144MYLK0.15029925
145PIK3CG0.14919937

Predicted pathways (KEGG)

RankGene SetZ-score
1* ECM-receptor interaction_Homo sapiens_hsa045122.71574109
2Adherens junction_Homo sapiens_hsa045202.67796723
3* Small cell lung cancer_Homo sapiens_hsa052222.39423544
4* Focal adhesion_Homo sapiens_hsa045102.08814801
5Leukocyte transendothelial migration_Homo sapiens_hsa046701.92144814
6Proteoglycans in cancer_Homo sapiens_hsa052051.85607293
7* Toxoplasmosis_Homo sapiens_hsa051451.81565871
8Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.80866721
9Amoebiasis_Homo sapiens_hsa051461.76608218
10Viral myocarditis_Homo sapiens_hsa054161.75200241
11* Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.71952809
12Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.64373885
13Notch signaling pathway_Homo sapiens_hsa043301.60514327
14Hippo signaling pathway_Homo sapiens_hsa043901.57258122
15MicroRNAs in cancer_Homo sapiens_hsa052061.54696743
16Chronic myeloid leukemia_Homo sapiens_hsa052201.54590662
17AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.54231765
18Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.54051519
19Basal cell carcinoma_Homo sapiens_hsa052171.52775010
20Protein digestion and absorption_Homo sapiens_hsa049741.52634235
21ErbB signaling pathway_Homo sapiens_hsa040121.51471393
22Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.49834288
23TGF-beta signaling pathway_Homo sapiens_hsa043501.48327604
24Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.41329973
25Tight junction_Homo sapiens_hsa045301.40086416
26Steroid biosynthesis_Homo sapiens_hsa001001.38393992
27* Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.38001435
28Other glycan degradation_Homo sapiens_hsa005111.37521313
29Leishmaniasis_Homo sapiens_hsa051401.37330959
30Glycosaminoglycan degradation_Homo sapiens_hsa005311.37002135
31Pancreatic cancer_Homo sapiens_hsa052121.31647077
32Thyroid cancer_Homo sapiens_hsa052161.27455827
33* Dilated cardiomyopathy_Homo sapiens_hsa054141.26380679
34Axon guidance_Homo sapiens_hsa043601.25524953
35Endometrial cancer_Homo sapiens_hsa052131.22991317
36* Pathways in cancer_Homo sapiens_hsa052001.22790605
37Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.22101755
38Transcriptional misregulation in cancer_Homo sapiens_hsa052021.20941308
39GnRH signaling pathway_Homo sapiens_hsa049121.19208804
40Platelet activation_Homo sapiens_hsa046111.18365444
41Osteoclast differentiation_Homo sapiens_hsa043801.13838905
42Staphylococcus aureus infection_Homo sapiens_hsa051501.13525857
43Dorso-ventral axis formation_Homo sapiens_hsa043201.13032780
44p53 signaling pathway_Homo sapiens_hsa041151.11871259
45HTLV-I infection_Homo sapiens_hsa051661.11759452
46Bladder cancer_Homo sapiens_hsa052191.08938579
47Colorectal cancer_Homo sapiens_hsa052101.08703944
48* Regulation of actin cytoskeleton_Homo sapiens_hsa048101.06335645
49Apoptosis_Homo sapiens_hsa042101.05568782
50Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.04706077
51Glioma_Homo sapiens_hsa052141.03248263
52Pertussis_Homo sapiens_hsa051331.03049750
53Prostate cancer_Homo sapiens_hsa052150.99008815
54Sphingolipid metabolism_Homo sapiens_hsa006000.98566389
55HIF-1 signaling pathway_Homo sapiens_hsa040660.98304521
56Thyroid hormone signaling pathway_Homo sapiens_hsa049190.97534487
57* PI3K-Akt signaling pathway_Homo sapiens_hsa041510.95138302
58Rap1 signaling pathway_Homo sapiens_hsa040150.94603400
59Hedgehog signaling pathway_Homo sapiens_hsa043400.94268157
60Antigen processing and presentation_Homo sapiens_hsa046120.92366908
61VEGF signaling pathway_Homo sapiens_hsa043700.92169406
62Acute myeloid leukemia_Homo sapiens_hsa052210.88034607
63Legionellosis_Homo sapiens_hsa051340.87814515
64Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.86226800
65Malaria_Homo sapiens_hsa051440.85336794
66Hepatitis B_Homo sapiens_hsa051610.84368594
67Galactose metabolism_Homo sapiens_hsa000520.83202511
68Insulin resistance_Homo sapiens_hsa049310.83197132
69Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.82401877
70TNF signaling pathway_Homo sapiens_hsa046680.81052909
71Influenza A_Homo sapiens_hsa051640.80620638
72Toll-like receptor signaling pathway_Homo sapiens_hsa046200.80508207
73Prion diseases_Homo sapiens_hsa050200.80291283
74Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.80138261
75Melanoma_Homo sapiens_hsa052180.79979887
76Jak-STAT signaling pathway_Homo sapiens_hsa046300.78922589
77Renal cell carcinoma_Homo sapiens_hsa052110.78596799
78NF-kappa B signaling pathway_Homo sapiens_hsa040640.78477498
79Insulin signaling pathway_Homo sapiens_hsa049100.75776221
80Central carbon metabolism in cancer_Homo sapiens_hsa052300.75332947
81Herpes simplex infection_Homo sapiens_hsa051680.74615636
82Viral carcinogenesis_Homo sapiens_hsa052030.73108740
83Prolactin signaling pathway_Homo sapiens_hsa049170.72366885
84Fatty acid biosynthesis_Homo sapiens_hsa000610.70583242
85FoxO signaling pathway_Homo sapiens_hsa040680.70528237
86Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.70470484
87Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.70420958
88Hepatitis C_Homo sapiens_hsa051600.70388889
89Melanogenesis_Homo sapiens_hsa049160.69176909
90Lysine degradation_Homo sapiens_hsa003100.68884266
91Measles_Homo sapiens_hsa051620.68491133
92Caffeine metabolism_Homo sapiens_hsa002320.68264067
93Cell cycle_Homo sapiens_hsa041100.67614984
94Wnt signaling pathway_Homo sapiens_hsa043100.67095921
95Shigellosis_Homo sapiens_hsa051310.67038679
96Salmonella infection_Homo sapiens_hsa051320.65790677
97Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.65342595
98* Hematopoietic cell lineage_Homo sapiens_hsa046400.65102752
99Glycerolipid metabolism_Homo sapiens_hsa005610.65014407
100Pancreatic secretion_Homo sapiens_hsa049720.64262123
101* Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.63999527
102Non-small cell lung cancer_Homo sapiens_hsa052230.63616361
103Mineral absorption_Homo sapiens_hsa049780.63283095
104Renin-angiotensin system_Homo sapiens_hsa046140.62846812
105Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.62795528
106Starch and sucrose metabolism_Homo sapiens_hsa005000.61531483
107NOD-like receptor signaling pathway_Homo sapiens_hsa046210.61016847
108B cell receptor signaling pathway_Homo sapiens_hsa046620.60155951
109N-Glycan biosynthesis_Homo sapiens_hsa005100.58242446
110Arachidonic acid metabolism_Homo sapiens_hsa005900.57243148
111Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.55545085
112Vitamin digestion and absorption_Homo sapiens_hsa049770.54678478
113Phosphatidylinositol signaling system_Homo sapiens_hsa040700.54462835
114Gap junction_Homo sapiens_hsa045400.54417419
115Neurotrophin signaling pathway_Homo sapiens_hsa047220.53739788
116mTOR signaling pathway_Homo sapiens_hsa041500.53591820
117Inositol phosphate metabolism_Homo sapiens_hsa005620.52737604
118Estrogen signaling pathway_Homo sapiens_hsa049150.52410233
119Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.52369482
120Glucagon signaling pathway_Homo sapiens_hsa049220.52085216
121PPAR signaling pathway_Homo sapiens_hsa033200.51679451
122Lysosome_Homo sapiens_hsa041420.51521694
123Tuberculosis_Homo sapiens_hsa051520.51082640
124Arginine biosynthesis_Homo sapiens_hsa002200.49783774
125Ribosome_Homo sapiens_hsa030100.48918769
126Renin secretion_Homo sapiens_hsa049240.47922026
127Bile secretion_Homo sapiens_hsa049760.47703964
128Chemokine signaling pathway_Homo sapiens_hsa040620.47080559
129Fat digestion and absorption_Homo sapiens_hsa049750.46787301
130Endocytosis_Homo sapiens_hsa041440.44735658
131Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.43677696
132Histidine metabolism_Homo sapiens_hsa003400.42571318
133Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.42389439
134Phospholipase D signaling pathway_Homo sapiens_hsa040720.41140453
135Thyroid hormone synthesis_Homo sapiens_hsa049180.38684075
136Complement and coagulation cascades_Homo sapiens_hsa046100.38063018
137Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.35668487
138Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.35637305

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