ITGA8

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Integrins are heterodimeric transmembrane receptor proteins that mediate numerous cellular processes including cell adhesion, cytoskeletal rearrangement, and activation of cell signaling pathways. Integrins are composed of alpha and beta subunits. This gene encodes the alpha 8 subunit of the heterodimeric integrin alpha8beta1 protein. The encoded protein is a single-pass type 1 membrane protein that contains multiple FG-GAP repeats. This repeat is predicted to fold into a beta propeller structure. This gene regulates the recruitment of mesenchymal cells into epithelial structures, mediates cell-cell interactions, and regulates neurite outgrowth of sensory and motor neurons. The integrin alpha8beta1 protein thus plays an important role in wound-healing and organogenesis. Mutations in this gene have been associated with renal hypodysplasia/aplasia-1 (RHDA1) and with several animal models of chronic kidney disease. Alternate splicing results in multiple transcript variants encoding distinct isoforms. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1glomerular visceral epithelial cell development (GO:0072015)7.51521967
2glomerular basement membrane development (GO:0032836)7.14516296
3glomerular epithelial cell development (GO:0072310)6.68717247
4neuron projection extension involved in neuron projection guidance (GO:1902284)5.18550588
5axon extension involved in axon guidance (GO:0048846)5.18550588
6glomerulus development (GO:0032835)5.04907129
7vascular endothelial growth factor signaling pathway (GO:0038084)4.70146909
8metanephric mesenchyme development (GO:0072075)4.61130766
9renal filtration (GO:0097205)4.54419433
10kidney mesenchyme development (GO:0072074)4.37208217
11lymph vessel development (GO:0001945)4.29564458
12retina vasculature morphogenesis in camera-type eye (GO:0061299)4.26529606
13glomerular filtration (GO:0003094)4.24570133
14cell migration involved in sprouting angiogenesis (GO:0002042)4.20761182
15lymphangiogenesis (GO:0001946)4.08591023
16negative regulation of axon guidance (GO:1902668)4.07869977
17negative regulation of axon extension involved in axon guidance (GO:0048843)4.06423779
18cell adhesion mediated by integrin (GO:0033627)4.04662909
19collagen fibril organization (GO:0030199)4.03302180
20regulation of axon guidance (GO:1902667)3.99328657
21regulation of axon extension involved in axon guidance (GO:0048841)3.97322096
22chondrocyte proliferation (GO:0035988)3.87171216
23sequestering of extracellular ligand from receptor (GO:0035581)3.71326693
24dichotomous subdivision of an epithelial terminal unit (GO:0060600)3.49448931
25peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)3.46504655
26surfactant homeostasis (GO:0043129)3.41601668
27coronary vasculature morphogenesis (GO:0060977)3.40780315
28regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)3.36466198
29endothelial cell chemotaxis (GO:0035767)3.35802674
30cell proliferation involved in metanephros development (GO:0072203)3.35393744
31cell migration involved in heart development (GO:0060973)3.35122965
32keratan sulfate catabolic process (GO:0042340)3.34599646
33extracellular matrix assembly (GO:0085029)3.34212954
34cellular response to vascular endothelial growth factor stimulus (GO:0035924)3.34008906
35lung vasculature development (GO:0060426)3.31577065
36mesenchymal-epithelial cell signaling (GO:0060638)3.29838946
37blood vessel endothelial cell migration (GO:0043534)3.28399280
38regulation of endothelial cell differentiation (GO:0045601)3.28196448
39extracellular fibril organization (GO:0043206)3.25507081
40cell differentiation involved in metanephros development (GO:0072202)3.24672364
41blood vessel maturation (GO:0001955)3.22306366
42endocrine hormone secretion (GO:0060986)3.22205641
43positive regulation of phosphoprotein phosphatase activity (GO:0032516)3.20371975
44blood vessel remodeling (GO:0001974)3.19608963
45multicellular organismal macromolecule metabolic process (GO:0044259)3.19416492
46negative regulation of fatty acid transport (GO:2000192)3.18450060
47collagen metabolic process (GO:0032963)3.13487271
48ganglion development (GO:0061548)3.13344983
49collagen catabolic process (GO:0030574)3.12053894
50adhesion of symbiont to host cell (GO:0044650)3.09468964
51virion attachment to host cell (GO:0019062)3.09468964
52mesenchymal cell differentiation involved in renal system development (GO:2001012)3.08298634
53mesenchymal cell differentiation involved in kidney development (GO:0072161)3.08298634
54multicellular organismal catabolic process (GO:0044243)3.06808031
55fibroblast migration (GO:0010761)3.05885922
56wound healing, spreading of epidermal cells (GO:0035313)3.05551136
57endodermal cell differentiation (GO:0035987)3.05002589
58hippo signaling (GO:0035329)3.04356465
59artery development (GO:0060840)3.03775060
60multicellular organismal metabolic process (GO:0044236)3.01577134
61basement membrane organization (GO:0071711)3.01126264
62protein heterotrimerization (GO:0070208)3.01090390
63patterning of blood vessels (GO:0001569)2.98997054
64vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.98473318
65bone trabecula formation (GO:0060346)2.98197950
66protein localization to cell surface (GO:0034394)2.95524084
67protein localization to endosome (GO:0036010)2.94821627
68* substrate adhesion-dependent cell spreading (GO:0034446)2.94402872
69regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)2.91824973
70midgut development (GO:0007494)2.89971626
71muscle cell migration (GO:0014812)2.89836273
72positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-2.89088131
73artery morphogenesis (GO:0048844)2.87654168
74endothelial cell morphogenesis (GO:0001886)2.86560601
75endothelium development (GO:0003158)2.86466952
76metanephric epithelium development (GO:0072207)2.85288634
77stress fiber assembly (GO:0043149)2.84295580
78respiratory tube development (GO:0030323)2.83867099
79positive regulation of endothelial cell differentiation (GO:0045603)2.83853943
80positive regulation of catenin import into nucleus (GO:0035413)2.82452148
81G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071992.79437785
82mesonephric tubule development (GO:0072164)2.78489894
83regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.78254842
84mesonephric epithelium development (GO:0072163)2.78063699
85pericardium development (GO:0060039)2.76110026
86extracellular matrix disassembly (GO:0022617)2.75449084
87substrate-dependent cell migration (GO:0006929)2.74919392
88planar cell polarity pathway involved in neural tube closure (GO:0090179)2.74305872
89insulin-like growth factor receptor signaling pathway (GO:0048009)2.74200475
90cardiac myofibril assembly (GO:0055003)2.73393976
91positive regulation of vasculogenesis (GO:2001214)2.73066404
92fibril organization (GO:0097435)2.71946764
93chemical homeostasis within a tissue (GO:0048875)2.70074878
94chondrocyte development (GO:0002063)2.69707333
95* smooth muscle tissue development (GO:0048745)2.69334663
96positive regulation of mesenchymal cell proliferation (GO:0002053)2.68458943
97endocardial cushion morphogenesis (GO:0003203)2.67099312
98epithelial cell differentiation involved in kidney development (GO:0035850)2.66984247
99type B pancreatic cell proliferation (GO:0044342)2.66820708
100cell proliferation involved in kidney development (GO:0072111)2.66691305
101extracellular regulation of signal transduction (GO:1900115)2.66233176
102extracellular negative regulation of signal transduction (GO:1900116)2.66233176
103branching involved in salivary gland morphogenesis (GO:0060445)2.66170233
104lung lobe morphogenesis (GO:0060463)2.66132133
105negative regulation of cell fate specification (GO:0009996)2.65120958
106cGMP-mediated signaling (GO:0019934)2.64845368
107regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)2.64214021
108aorta morphogenesis (GO:0035909)2.64049113
109regulation of branching involved in salivary gland morphogenesis (GO:0060693)2.63831546
110adhesion of symbiont to host (GO:0044406)2.62808320
111facial nerve structural organization (GO:0021612)2.62690953
112venous blood vessel morphogenesis (GO:0048845)2.62496455
113endocardial cushion development (GO:0003197)2.62408091
114ureteric bud development (GO:0001657)2.61653025
115mesenchyme morphogenesis (GO:0072132)2.61427879
116apoptotic cell clearance (GO:0043277)2.61178033
117regulation of heart morphogenesis (GO:2000826)2.59871114
118polarized epithelial cell differentiation (GO:0030859)2.59376286
119outflow tract septum morphogenesis (GO:0003148)2.58696602
120pattern specification involved in kidney development (GO:0061004)2.57956328
121sprouting angiogenesis (GO:0002040)2.57316050
122platelet-derived growth factor receptor signaling pathway (GO:0048008)2.56946966
123blood vessel morphogenesis (GO:0048514)2.56712357
124* mesodermal cell differentiation (GO:0048333)2.56509759
125negative regulation of vascular permeability (GO:0043116)2.56057463
126epithelial cell-cell adhesion (GO:0090136)2.55944603
127regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.55832913
128regulation of integrin-mediated signaling pathway (GO:2001044)2.55607422
129camera-type eye morphogenesis (GO:0048593)2.55469602
130positive regulation of cell adhesion mediated by integrin (GO:0033630)2.55413442
131anterior/posterior axis specification, embryo (GO:0008595)2.53489901
132cellular response to epinephrine stimulus (GO:0071872)2.53321379
133relaxation of smooth muscle (GO:0044557)2.51611460
134regulation of calcineurin-NFAT signaling cascade (GO:0070884)2.48687670
135low-density lipoprotein particle clearance (GO:0034383)2.45403888
136response to epinephrine (GO:0071871)2.42499419
137cartilage development involved in endochondral bone morphogenesis (GO:0060351)2.41168993
138regulation of smooth muscle cell differentiation (GO:0051150)2.40702447
139regulation of cardiac muscle cell differentiation (GO:2000725)2.40364003
140vasculature development (GO:0001944)2.40124678
141mesenchymal cell differentiation (GO:0048762)2.39114952
142regulation of vasculogenesis (GO:2001212)2.37336086
143tonic smooth muscle contraction (GO:0014820)2.36290091
144smooth muscle cell differentiation (GO:0051145)2.35553945
145* extracellular matrix organization (GO:0030198)2.33274663
146skin morphogenesis (GO:0043589)2.33161847
147* extracellular structure organization (GO:0043062)2.32443812
148myofibril assembly (GO:0030239)2.30031042
149adrenal gland development (GO:0030325)2.27729600
150lung alveolus development (GO:0048286)2.27376980

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TRIM28_21343339_ChIP-Seq_HEK293_Human4.62477804
2TP63_17297297_ChIP-ChIP_HaCaT_Human2.88779191
3ESR1_22446102_ChIP-Seq_UTERUS_Mouse2.69768063
4RARG_19884340_ChIP-ChIP_MEFs_Mouse2.46585704
5WT1_19549856_ChIP-ChIP_CCG9911_Human2.46205647
6CLOCK_20551151_ChIP-Seq_293T_Human2.44487743
7EP300_21415370_ChIP-Seq_HL-1_Mouse2.43887515
8ESR1_21235772_ChIP-Seq_MCF-7_Human2.39544647
9EED_16625203_ChIP-ChIP_MESCs_Mouse2.26945096
10PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.20230793
11SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.11603689
12GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.09918203
13EZH2_18974828_ChIP-Seq_MESCs_Mouse2.09271711
14RNF2_18974828_ChIP-Seq_MESCs_Mouse2.09271711
15ESR2_21235772_ChIP-Seq_MCF-7_Human2.06226442
16ZNF217_24962896_ChIP-Seq_MCF-7_Human2.05619162
17SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.01516433
18TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.97307690
19CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.94379808
20WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.92837972
21SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.88920140
22SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.88241746
23CJUN_26792858_Chip-Seq_BT549_Human1.86240062
24EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.84066398
25CDX2_19796622_ChIP-Seq_MESCs_Mouse1.78580340
26CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.78452491
27NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.77314796
28PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.73454706
29SMAD_19615063_ChIP-ChIP_OVARY_Human1.69042212
30TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.66861226
31* SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.66560734
32RBPJ_22232070_ChIP-Seq_NCS_Mouse1.66351767
33PIAS1_25552417_ChIP-Seq_VCAP_Human1.63790470
34RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.61396743
35ESR1_20079471_ChIP-ChIP_T-47D_Human1.61083689
36AHR_22903824_ChIP-Seq_MCF-7_Human1.60089681
37ZFP57_27257070_Chip-Seq_ESCs_Mouse1.59792669
38JARID2_20075857_ChIP-Seq_MESCs_Mouse1.58745173
39TP53_18474530_ChIP-ChIP_U2OS_Human1.58510187
40FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.56966123
41PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.54498169
42PPAR_26484153_Chip-Seq_NCI-H1993_Human1.54132150
43* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.50776589
44GATA2_21666600_ChIP-Seq_HMVEC_Human1.50143368
45MTF2_20144788_ChIP-Seq_MESCs_Mouse1.49994554
46* NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.48691211
47* NRF2_20460467_ChIP-Seq_MEFs_Mouse1.48691211
48JARID2_20064375_ChIP-Seq_MESCs_Mouse1.47753402
49BRD4_25478319_ChIP-Seq_HGPS_Human1.46613854
50NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.44485526
51TP53_16413492_ChIP-PET_HCT116_Human1.42849545
52* ARNT_22903824_ChIP-Seq_MCF-7_Human1.36205224
53ISL1_27105846_Chip-Seq_CPCs_Mouse1.35420088
54SOX9_24532713_ChIP-Seq_HFSC_Mouse1.35149789
55TP53_20018659_ChIP-ChIP_R1E_Mouse1.34820229
56EZH2_27304074_Chip-Seq_ESCs_Mouse1.34094314
57BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.34087863
58RNF2_27304074_Chip-Seq_ESCs_Mouse1.32519956
59PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.32427128
60RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.31294099
61ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.30955585
62CBX2_27304074_Chip-Seq_ESCs_Mouse1.30940215
63GBX2_23144817_ChIP-Seq_PC3_Human1.30929875
64BP1_19119308_ChIP-ChIP_Hs578T_Human1.30305417
65SMAD4_21799915_ChIP-Seq_A2780_Human1.29391883
66TCF4_18268006_ChIP-ChIP_LS174T_Human1.28029029
67SALL4_18804426_ChIP-ChIP_XEN_Mouse1.25582686
68BCAT_22108803_ChIP-Seq_LS180_Human1.24704310
69CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.23805693
70FOXO3_23340844_ChIP-Seq_DLD1_Human1.22823576
71* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.22232122
72TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.20889692
73PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.20454695
74AR_21572438_ChIP-Seq_LNCaP_Human1.17686666
75SOX2_20726797_ChIP-Seq_SW620_Human1.16767377
76AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.16719389
77TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.16145268
78ERG_21242973_ChIP-ChIP_JURKAT_Human1.15502236
79DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.14717743
80NFIB_24661679_ChIP-Seq_LUNG_Mouse1.14646521
81NR3C1_23031785_ChIP-Seq_PC12_Mouse1.12552045
82* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.11694528
83TBX20_22080862_ChIP-Seq_HEART_Mouse1.10428294
84TBX20_22328084_ChIP-Seq_HEART_Mouse1.10428294
85PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.10219517
86* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.06863687
87ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.06731116
88* EZH2_22144423_ChIP-Seq_EOC_Human1.05783519
89SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.05088790
90SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.04592918
91SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.04169076
92TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.04034509
93SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.03353332
94SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.03353332
95FOXM1_26456572_ChIP-Seq_MCF-7_Human1.01961798
96HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.01784581
97SMAD3_21741376_ChIP-Seq_HESCs_Human1.00465222
98SMAD3_21741376_ChIP-Seq_EPCs_Human1.00111682
99YAP1_20516196_ChIP-Seq_MESCs_Mouse0.99635829
100TOP2B_26459242_ChIP-Seq_MCF-7_Human0.99374621
101SUZ12_27294783_Chip-Seq_ESCs_Mouse0.99011240
102RXR_22108803_ChIP-Seq_LS180_Human0.98548055
103FOXA2_19822575_ChIP-Seq_HepG2_Human0.97806512
104* EZH2_27294783_Chip-Seq_ESCs_Mouse0.97016498
105CTNNB1_20460455_ChIP-Seq_HCT116_Human0.96960990
106RING1B_27294783_Chip-Seq_NPCs_Mouse0.96834050
107NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.96752469
108MEF2A_21415370_ChIP-Seq_HL-1_Mouse0.96560349
109DROSHA_22980978_ChIP-Seq_HELA_Human0.96335154
110SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.94857610
111AR_25329375_ChIP-Seq_VCAP_Human0.94804855
112FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.94519062
113STAT3_23295773_ChIP-Seq_U87_Human0.94062717
114CDX2_20551321_ChIP-Seq_CACO-2_Human0.93881470
115ESR1_17901129_ChIP-ChIP_LIVER_Mouse0.93691787
116NR3C1_21868756_ChIP-Seq_MCF10A_Human0.93465629
117RING1B_27294783_Chip-Seq_ESCs_Mouse0.93325479
118HIF1A_21447827_ChIP-Seq_MCF-7_Human0.93300266
119* POU3F2_20337985_ChIP-ChIP_501MEL_Human0.91745882
120TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.91108672
121SOX2_21211035_ChIP-Seq_LN229_Gbm0.91020343
122LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.90599050
123SMAD4_21741376_ChIP-Seq_HESCs_Human0.90490078
124* KDM2B_26808549_Chip-Seq_REH_Human0.89647057
125MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.89565567
126THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.89546843
127KDM2B_26808549_Chip-Seq_SUP-B15_Human0.88828965
128P300_19829295_ChIP-Seq_ESCs_Human0.88753238
129TBX3_20139965_ChIP-Seq_ESCs_Mouse0.88486717
130SMC1_22415368_ChIP-Seq_MEFs_Mouse0.88196799

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen5.36271463
2MP0004272_abnormal_basement_membrane4.36867214
3MP0010368_abnormal_lymphatic_system4.21326654
4MP0005275_abnormal_skin_tensile3.88747478
5MP0001958_emphysema3.57126583
6MP0005503_abnormal_tendon_morphology3.21094581
7MP0003705_abnormal_hypodermis_morpholog3.06032846
8MP0005623_abnormal_meninges_morphology3.03764966
9MP0001879_abnormal_lymphatic_vessel2.99966248
10MP0003279_aneurysm2.88164352
11MP0009384_cardiac_valve_regurgitation2.55429900
12* MP0000534_abnormal_ureter_morphology2.19764108
13MP0003566_abnormal_cell_adhesion2.18352013
14MP0000751_myopathy2.17034786
15MP0003950_abnormal_plasma_membrane2.16389033
16MP0000537_abnormal_urethra_morphology2.14315865
17MP0000767_abnormal_smooth_muscle2.13099665
18* MP0003942_abnormal_urinary_system2.13013609
19MP0005670_abnormal_white_adipose2.10192856
20MP0002295_abnormal_pulmonary_circulatio2.05696155
21MP0001542_abnormal_bone_strength1.96980755
22MP0003385_abnormal_body_wall1.84517267
23MP0003091_abnormal_cell_migration1.67387850
24MP0003115_abnormal_respiratory_system1.62103623
25MP0010030_abnormal_orbit_morphology1.59664796
26MP0002282_abnormal_trachea_morphology1.58884070
27MP0005508_abnormal_skeleton_morphology1.58297814
28MP0003941_abnormal_skin_development1.57969985
29MP0009250_abnormal_appendicular_skeleto1.56857044
30MP0004084_abnormal_cardiac_muscle1.55590112
31MP0005257_abnormal_intraocular_pressure1.55483350
32MP0009053_abnormal_anal_canal1.54926709
33MP0000516_abnormal_urinary_system1.47927196
34MP0005367_renal/urinary_system_phenotyp1.47927196
35MP0004130_abnormal_muscle_cell1.42377156
36MP0001661_extended_life_span1.41419930
37MP0006138_congestive_heart_failure1.41100980
38MP0005595_abnormal_vascular_smooth1.37949358
39MP0009780_abnormal_chondrocyte_physiolo1.36033625
40MP0002249_abnormal_larynx_morphology1.32876276
41MP0002128_abnormal_blood_circulation1.32782275
42MP0003045_fibrosis1.32422454
43MP0000013_abnormal_adipose_tissue1.31620658
44MP0005023_abnormal_wound_healing1.26768108
45MP0001614_abnormal_blood_vessel1.26638033
46MP0003935_abnormal_craniofacial_develop1.25310831
47MP0006054_spinal_hemorrhage1.25159892
48MP0002925_abnormal_cardiovascular_devel1.20417466
49MP0002932_abnormal_joint_morphology1.19770458
50MP0010234_abnormal_vibrissa_follicle1.19213309
51MP0001986_abnormal_taste_sensitivity1.18084371
52MP0000538_abnormal_urinary_bladder1.16652921
53MP0002168_other_aberrant_phenotype1.16208902
54MP0002133_abnormal_respiratory_system1.14867271
55MP0005388_respiratory_system_phenotype1.14867271
56MP0000163_abnormal_cartilage_morphology1.12284573
57MP0002108_abnormal_muscle_morphology1.11969538
58MP0002896_abnormal_bone_mineralization1.11602683
59MP0003122_maternal_imprinting1.09736905
60MP0002115_abnormal_skeleton_extremities1.07271693
61MP0000462_abnormal_digestive_system1.06979355
62MP0001175_abnormal_lung_morphology1.04536307
63MP0005167_abnormal_blood-brain_barrier1.02934790
64MP0003937_abnormal_limbs/digits/tail_de1.02813187
65MP0002233_abnormal_nose_morphology1.02220728
66MP0002060_abnormal_skin_morphology1.01281646
67MP0001664_abnormal_digestion1.00573230
68MP0000733_abnormal_muscle_development1.00560156
69* MP0002135_abnormal_kidney_morphology1.00067876
70MP0001270_distended_abdomen0.99860109
71MP0000762_abnormal_tongue_morphology0.98512191
72MP0000230_abnormal_systemic_arterial0.98096953
73MP0004782_abnormal_surfactant_physiolog0.98092324
74MP0004883_abnormal_blood_vessel0.96862245
75MP0003252_abnormal_bile_duct0.94983204
76MP0010352_gastrointestinal_tract_polyps0.94221136
77MP0005164_abnormal_response_to0.93257815
78MP0003283_abnormal_digestive_organ0.93179831
79MP0002127_abnormal_cardiovascular_syste0.93121545
80MP0004134_abnormal_chest_morphology0.93026422
81MP0002971_abnormal_brown_adipose0.90757072
82MP0008004_abnormal_stomach_pH0.90059164
83MP0000428_abnormal_craniofacial_morphol0.89519668
84MP0001177_atelectasis0.89346507
85MP0003828_pulmonary_edema0.89343364
86MP0002113_abnormal_skeleton_development0.89086122
87MP0005197_abnormal_uvea_morphology0.88910521
88MP0003755_abnormal_palate_morphology0.88883428
89MP0001299_abnormal_eye_distance/0.88766700
90MP0000003_abnormal_adipose_tissue0.87706702
91MP0005375_adipose_tissue_phenotype0.86553378
92MP0005385_cardiovascular_system_phenoty0.85982087
93MP0001544_abnormal_cardiovascular_syste0.85982087
94MP0002109_abnormal_limb_morphology0.84521661
95MP0002254_reproductive_system_inflammat0.84261143
96MP0010386_abnormal_urinary_bladder0.82930232
97MP0004484_altered_response_of0.82334453
98MP0004036_abnormal_muscle_relaxation0.81994258
99MP0005248_abnormal_Harderian_gland0.81902371
100MP0000266_abnormal_heart_morphology0.81840125
101MP0000049_abnormal_middle_ear0.80765472
102MP0001756_abnormal_urination0.79974863
103MP0000432_abnormal_head_morphology0.79288170
104MP0001915_intracranial_hemorrhage0.78973663
105MP0004085_abnormal_heartbeat0.78177580
106MP0010630_abnormal_cardiac_muscle0.77219904
107MP0003300_gastrointestinal_ulcer0.76837748
108MP0008775_abnormal_heart_ventricle0.76584281
109MP0003123_paternal_imprinting0.73254716
110MP0000759_abnormal_skeletal_muscle0.72304908
111MP0000566_synostosis0.71079046
112MP0002116_abnormal_craniofacial_bone0.70862223
113MP0005171_absent_coat_pigmentation0.70220637
114MP0005193_abnormal_anterior_eye0.69621177
115MP0005390_skeleton_phenotype0.69588803
116MP0004043_abnormal_pH_regulation0.69316195
117MP0001849_ear_inflammation0.68200192
118MP0002933_joint_inflammation0.68079786
119MP0001784_abnormal_fluid_regulation0.67967297
120MP0003011_delayed_dark_adaptation0.67797474
121MP0005620_abnormal_muscle_contractility0.67433295
122MP0002136_abnormal_kidney_physiology0.67051539
123MP0005666_abnormal_adipose_tissue0.66706349
124MP0000749_muscle_degeneration0.65922350
125MP0001243_abnormal_dermal_layer0.64946684
126MP0005369_muscle_phenotype0.64099828
127MP0000750_abnormal_muscle_regeneration0.63946903
128MP0005165_increased_susceptibility_to0.61997812
129MP0004215_abnormal_myocardial_fiber0.61461669
130MP0002972_abnormal_cardiac_muscle0.60905159

Predicted human phenotypes

RankGene SetZ-score
1Aortic aneurysm (HP:0004942)5.26016669
2Aortic dissection (HP:0002647)4.73647840
3Protrusio acetabuli (HP:0003179)4.70183067
4Broad metatarsal (HP:0001783)4.56013420
5Premature rupture of membranes (HP:0001788)4.35183950
6Type 1 muscle fiber predominance (HP:0003803)4.06243650
7Shallow orbits (HP:0000586)4.00997466
8Cerebral aneurysm (HP:0004944)3.92310885
9Vascular tortuosity (HP:0004948)3.91581979
10Focal segmental glomerulosclerosis (HP:0000097)3.88587195
11Ankle contracture (HP:0006466)3.80914245
12Mesangial abnormality (HP:0001966)3.65254117
13Hematochezia (HP:0002573)3.47992516
14Arterial tortuosity (HP:0005116)3.32098780
15Follicular hyperkeratosis (HP:0007502)3.25212399
16Bladder diverticulum (HP:0000015)3.20629136
17Mitral valve prolapse (HP:0001634)3.18320984
18Atrophic scars (HP:0001075)3.08777888
19Aneurysm (HP:0002617)3.08569364
20Glomerulosclerosis (HP:0000096)3.04406762
21Camptodactyly of toe (HP:0001836)2.93189399
22Dilatation of the ascending aorta (HP:0005111)2.90999040
23Lymphangioma (HP:0100764)2.86282815
24Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.82131438
25Short 4th metacarpal (HP:0010044)2.82131438
26Slender build (HP:0001533)2.71174254
27Nephritis (HP:0000123)2.69893293
28Increased density of long bones (HP:0006392)2.62728682
29Soft skin (HP:0000977)2.61803361
30Pulmonary artery stenosis (HP:0004415)2.59177519
31Polycythemia (HP:0001901)2.58887112
32Increased variability in muscle fiber diameter (HP:0003557)2.56280197
33Neoplasm of the heart (HP:0100544)2.53354495
34Broad ribs (HP:0000885)2.50756279
35Overgrowth (HP:0001548)2.48863606
36Deep venous thrombosis (HP:0002625)2.47908228
37Venous insufficiency (HP:0005293)2.47840352
38Long toe (HP:0010511)2.47487884
39Wormian bones (HP:0002645)2.44694350
40Knee flexion contracture (HP:0006380)2.41055855
41Abnormality of the 4th metacarpal (HP:0010012)2.39351803
42Hydroureter (HP:0000072)2.37233662
43Peritonitis (HP:0002586)2.36489412
44Papilledema (HP:0001085)2.35675087
45Hypoventilation (HP:0002791)2.35394663
46Increased corneal curvature (HP:0100692)2.33424476
47Keratoconus (HP:0000563)2.33424476
48Renal duplication (HP:0000075)2.33190203
49Decreased circulating renin level (HP:0003351)2.31771636
50Round ear (HP:0100830)2.29651008
51Hypoplasia of the iris (HP:0007676)2.28554215
52Bowel diverticulosis (HP:0005222)2.27369978
53Ectopia lentis (HP:0001083)2.26686167
54Abnormal albumin level (HP:0012116)2.23905187
55Hypoalbuminemia (HP:0003073)2.23905187
56Bicuspid aortic valve (HP:0001647)2.23592514
57Tubulointerstitial fibrosis (HP:0005576)2.20519051
58Buphthalmos (HP:0000557)2.18076725
59Chondrocalcinosis (HP:0000934)2.17916866
60Hepatoblastoma (HP:0002884)2.16739669
61Venous abnormality (HP:0002624)2.15623391
62Disproportionate tall stature (HP:0001519)2.15433860
63Mitral regurgitation (HP:0001653)2.14964398
64Bell-shaped thorax (HP:0001591)2.14135236
65Infantile muscular hypotonia (HP:0008947)2.13867538
66Joint contractures involving the joints of the feet (HP:0100492)2.13841831
67Flexion contracture of toe (HP:0005830)2.13841831
68Hypoplastic ischia (HP:0003175)2.13833635
69Coronal craniosynostosis (HP:0004440)2.12724205
70Hip contracture (HP:0003273)2.12673534
71Spontaneous hematomas (HP:0007420)2.12530912
72Blue sclerae (HP:0000592)2.10940749
73Midline defect of the nose (HP:0004122)2.10291261
74Stage 5 chronic kidney disease (HP:0003774)2.09322154
75Wrist flexion contracture (HP:0001239)2.08892699
76Mesomelia (HP:0003027)2.06504746
77Vitreoretinal degeneration (HP:0000655)2.05946149
78Visceral angiomatosis (HP:0100761)2.05557672
79Fragile skin (HP:0001030)2.05517375
80Wide anterior fontanel (HP:0000260)2.05172426
81Abnormality of dentin (HP:0010299)2.04999703
82Hyperextensible skin (HP:0000974)2.04516916
83Ulnar bowing (HP:0003031)2.04197073
84Distal arthrogryposis (HP:0005684)2.03573177
85Short hallux (HP:0010109)2.03269922
86Abnormality of skeletal muscle fiber size (HP:0012084)2.02495294
87Abnormality of Sharpey fibers (HP:0100685)2.01920703
88Aortic regurgitation (HP:0001659)2.01680057
89Neonatal short-limb short stature (HP:0008921)1.97237578
90Vertebral compression fractures (HP:0002953)1.96870626
91Morphological abnormality of the middle ear (HP:0008609)1.96569580
92Increased connective tissue (HP:0009025)1.96311090
93Mild short stature (HP:0003502)1.96184129
94Spondylolisthesis (HP:0003302)1.95588129
95Limited hip movement (HP:0008800)1.94935029
96Abnormality of the ischium (HP:0003174)1.94875323
97Mildly elevated creatine phosphokinase (HP:0008180)1.94477572
98Hyperactive renin-angiotensin system (HP:0000841)1.94103425
99Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.93206168
100Hemangiomatosis (HP:0007461)1.92327636
101Osteolytic defects of the phalanges of the hand (HP:0009771)1.91771366
102Osteolytic defects of the hand bones (HP:0009699)1.91771366
103Cervical subluxation (HP:0003308)1.90600518
104Aortic valve stenosis (HP:0001650)1.90092348
105Abnormality of the anterior chamber (HP:0000593)1.89486491
106Glomerulonephritis (HP:0000099)1.88446903
107Shawl scrotum (HP:0000049)1.86018031
108Rectal prolapse (HP:0002035)1.85681586
109Striae distensae (HP:0001065)1.85652752
110Biconcave vertebral bodies (HP:0004586)1.85304765
111Joint laxity (HP:0001388)1.83834636
112Broad toe (HP:0001837)1.83150575
113Elbow flexion contracture (HP:0002987)1.82338661
114Malnutrition (HP:0004395)1.81633268
115Spinal rigidity (HP:0003306)1.80755777
116Aplasia/Hypoplasia of the hallux (HP:0008362)1.79889496
117Abnormality of the peritoneum (HP:0002585)1.79881111
118Turricephaly (HP:0000262)1.78559612
119Cardiovascular calcification (HP:0011915)1.77949326
120Esophageal varix (HP:0002040)1.77818114
121Persistence of primary teeth (HP:0006335)1.77153261
122Osteoarthritis (HP:0002758)1.76332152
123Interstitial pulmonary disease (HP:0006530)1.75985778
124Genu recurvatum (HP:0002816)1.73168902
125Mitral stenosis (HP:0001718)1.71640473
126Abnormality of the acetabulum (HP:0003170)1.70008964
127Joint stiffness (HP:0001387)1.69139916
128Arachnodactyly (HP:0001166)1.67877958
129Ovoid vertebral bodies (HP:0003300)1.66754522
130Pulmonary hypertension (HP:0002092)1.64992841
131Short clavicles (HP:0000894)1.64402822
132Redundant skin (HP:0001582)1.64088503
133Protruding ear (HP:0000411)1.61564332
134Bilateral sensorineural hearing impairment (HP:0008619)1.60750902
135Narrow nasal bridge (HP:0000446)1.59625725

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TIE14.41130730
2DDR23.99379315
3TGFBR23.70979288
4TTN3.68236575
5LATS13.45562485
6EPHB23.36293203
7PDGFRA3.31806751
8MYLK3.02933692
9EPHA32.95856564
10PIK3CG2.92112143
11WNK42.54686583
12TRIB32.16585822
13DMPK2.03821852
14GRK71.95705520
15RIPK11.94567527
16STK391.86654746
17FER1.84985891
18SIK11.80387061
19TGFBR11.74962544
20PAK41.68138186
21KDR1.66933370
22LATS21.63483502
23CAMK1G1.63013128
24PAK21.61136892
25NTRK11.52600525
26CAMK1D1.43052616
27PDGFRB1.41699002
28PTK2B1.39750269
29LIMK11.37191194
30NLK1.37121759
31PKN21.35617219
32ERN11.34826346
33PAK31.32733965
34PTK21.30119909
35FGFR41.27578211
36PTK61.27233237
37FGFR21.26701486
38OXSR11.25738597
39EPHB11.20909569
40TESK11.14278897
41FLT31.12348396
42LRRK21.07893412
43TRPM71.07256484
44NUAK11.02667149
45OBSCN0.98048090
46PIK3CA0.97893174
47PRKCH0.97700765
48MET0.93375957
49FRK0.92596792
50ROCK10.91339325
51FGFR30.90558533
52STK38L0.90005240
53MAPK70.87528018
54KIT0.87397048
55STK30.87230483
56WNK10.87065930
57CAMK10.85614896
58FGFR10.85524276
59BMX0.81744319
60MAPKAPK30.80570828
61AKT30.80507917
62ACVR1B0.79927854
63RET0.75982792
64GRK10.75206644
65MAP3K70.74866873
66MELK0.72766401
67EEF2K0.72518667
68NEK90.64431683
69MTOR0.64362419
70DAPK30.64302728
71MAPK120.63795673
72PRKD10.60559589
73GSK3A0.60525699
74PRKAA10.59757921
75MATK0.56667463
76ERBB20.56158742
77ERBB40.55256125
78PRKD20.54678954
79PRKD30.54467138
80MAP3K60.54276863
81MAPK40.53513782
82KSR20.53241067
83MAP2K10.52857342
84ERBB30.51316170
85JAK10.49303371
86SGK4940.48974187
87SGK2230.48974187
88PRKCE0.48159127
89SRC0.47295974
90ADRBK20.45517253
91INSR0.44537792
92ILK0.43221483
93ROCK20.42571333
94MAP2K20.42294361
95IGF1R0.42217768
96EPHA20.41203127
97CAMK2B0.40842657
98ABL20.40465134
99SGK30.39851644
100PINK10.39601038
101CDK60.38102800
102MARK20.36490008
103PRKG10.36035460
104CDC42BPA0.33807549
105MAP3K20.32865652
106ABL10.31983561
107PLK20.31899643
108ZAP700.31726974
109GRK50.30474350
110MAPK10.29771970
111LMTK20.29626226
112NTRK30.29556539
113STK240.28803647
114EGFR0.28587699
115RPS6KA20.28443896
116FYN0.28381975
117RPS6KA60.27439422
118DYRK1B0.27029850
119STK380.26302436
120PDPK10.25317872
121STK100.25277437
122KSR10.24852595
123PRKAA20.24187039
124TAOK10.23790767
125ADRBK10.23378985
126PDK20.23235633
127SGK20.22508884
128DAPK20.22179517
129CAMK40.21636978
130EPHA40.18190127
131PRKG20.17516477

Predicted pathways (KEGG)

RankGene SetZ-score
1* ECM-receptor interaction_Homo sapiens_hsa045123.96263974
2* Focal adhesion_Homo sapiens_hsa045102.95850514
3Protein digestion and absorption_Homo sapiens_hsa049742.44322472
4Adherens junction_Homo sapiens_hsa045202.33497927
5Amoebiasis_Homo sapiens_hsa051462.26518615
6AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049332.09672650
7Small cell lung cancer_Homo sapiens_hsa052222.08764024
8Proteoglycans in cancer_Homo sapiens_hsa052051.92151920
9* Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.91963503
10Renin-angiotensin system_Homo sapiens_hsa046141.81446259
11Axon guidance_Homo sapiens_hsa043601.79896118
12Hippo signaling pathway_Homo sapiens_hsa043901.74949896
13* Dilated cardiomyopathy_Homo sapiens_hsa054141.74240561
14* Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.68364703
15TGF-beta signaling pathway_Homo sapiens_hsa043501.67990830
16Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.55274517
17Basal cell carcinoma_Homo sapiens_hsa052171.47502106
18Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.37834545
19Bladder cancer_Homo sapiens_hsa052191.37680644
20Vascular smooth muscle contraction_Homo sapiens_hsa042701.36778905
21MicroRNAs in cancer_Homo sapiens_hsa052061.36404965
22Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.34148694
23Complement and coagulation cascades_Homo sapiens_hsa046101.30683882
24Leukocyte transendothelial migration_Homo sapiens_hsa046701.29247118
25* PI3K-Akt signaling pathway_Homo sapiens_hsa041511.29012852
26* Regulation of actin cytoskeleton_Homo sapiens_hsa048101.28984856
27Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.28401819
28Rap1 signaling pathway_Homo sapiens_hsa040151.27397029
29Glycosaminoglycan degradation_Homo sapiens_hsa005311.26630115
30Tight junction_Homo sapiens_hsa045301.21354755
31Renin secretion_Homo sapiens_hsa049241.20054624
32Propanoate metabolism_Homo sapiens_hsa006401.17999444
33Pancreatic cancer_Homo sapiens_hsa052121.15045472
34Wnt signaling pathway_Homo sapiens_hsa043101.15021820
35Platelet activation_Homo sapiens_hsa046111.14177821
36alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.12865377
37Pathways in cancer_Homo sapiens_hsa052001.12156481
38Melanoma_Homo sapiens_hsa052181.07945022
39Hedgehog signaling pathway_Homo sapiens_hsa043401.03899607
40Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.02743062
41cGMP-PKG signaling pathway_Homo sapiens_hsa040221.02474462
42Prostate cancer_Homo sapiens_hsa052150.99977712
43Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.99395734
44Glioma_Homo sapiens_hsa052140.99352893
45Fatty acid elongation_Homo sapiens_hsa000620.99115912
46Sulfur metabolism_Homo sapiens_hsa009200.98120555
47Dorso-ventral axis formation_Homo sapiens_hsa043200.98106277
48Lysine degradation_Homo sapiens_hsa003100.94827515
49Renal cell carcinoma_Homo sapiens_hsa052110.94807978
50Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.94738113
51Calcium signaling pathway_Homo sapiens_hsa040200.93641916
52Chronic myeloid leukemia_Homo sapiens_hsa052200.93618285
53Melanogenesis_Homo sapiens_hsa049160.93364387
54Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.92599181
55Notch signaling pathway_Homo sapiens_hsa043300.91378099
56Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.90873806
57beta-Alanine metabolism_Homo sapiens_hsa004100.89769470
58Gap junction_Homo sapiens_hsa045400.89453827
59Caffeine metabolism_Homo sapiens_hsa002320.87505757
60Viral myocarditis_Homo sapiens_hsa054160.85930929
61Endometrial cancer_Homo sapiens_hsa052130.83570328
62Phenylalanine metabolism_Homo sapiens_hsa003600.82652074
63Glycerolipid metabolism_Homo sapiens_hsa005610.80897631
64Histidine metabolism_Homo sapiens_hsa003400.79876224
65Malaria_Homo sapiens_hsa051440.79323060
66ABC transporters_Homo sapiens_hsa020100.77118354
67Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.74484791
68Thyroid hormone synthesis_Homo sapiens_hsa049180.72829814
69PPAR signaling pathway_Homo sapiens_hsa033200.72264246
70Ovarian steroidogenesis_Homo sapiens_hsa049130.72115186
71Estrogen signaling pathway_Homo sapiens_hsa049150.71991847
72Colorectal cancer_Homo sapiens_hsa052100.71156670
73Adipocytokine signaling pathway_Homo sapiens_hsa049200.70735358
74Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.70348879
75Cocaine addiction_Homo sapiens_hsa050300.69894957
76Toxoplasmosis_Homo sapiens_hsa051450.69480168
77Bile secretion_Homo sapiens_hsa049760.69435051
78Insulin resistance_Homo sapiens_hsa049310.69412666
79Fatty acid degradation_Homo sapiens_hsa000710.69186450
80Fatty acid biosynthesis_Homo sapiens_hsa000610.68907103
81Salivary secretion_Homo sapiens_hsa049700.68241543
82Phospholipase D signaling pathway_Homo sapiens_hsa040720.67783025
83Oxytocin signaling pathway_Homo sapiens_hsa049210.66598744
84Ras signaling pathway_Homo sapiens_hsa040140.64756778
85Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.64410057
86Aldosterone synthesis and secretion_Homo sapiens_hsa049250.64015846
87Fatty acid metabolism_Homo sapiens_hsa012120.63651016
88Cyanoamino acid metabolism_Homo sapiens_hsa004600.62862996
89Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.62610573
90cAMP signaling pathway_Homo sapiens_hsa040240.60800385
91Tryptophan metabolism_Homo sapiens_hsa003800.60447088
92Insulin secretion_Homo sapiens_hsa049110.60288579
93Central carbon metabolism in cancer_Homo sapiens_hsa052300.59875756
94VEGF signaling pathway_Homo sapiens_hsa043700.58996561
95Gastric acid secretion_Homo sapiens_hsa049710.58333688
96Mineral absorption_Homo sapiens_hsa049780.57325335
97AMPK signaling pathway_Homo sapiens_hsa041520.57246787
98GnRH signaling pathway_Homo sapiens_hsa049120.54227959
99Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.54171739
100* Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.52295770
101Pertussis_Homo sapiens_hsa051330.51697914
102Circadian rhythm_Homo sapiens_hsa047100.51348323
103Primary bile acid biosynthesis_Homo sapiens_hsa001200.50977067
104Choline metabolism in cancer_Homo sapiens_hsa052310.50466255
105Tyrosine metabolism_Homo sapiens_hsa003500.50411931
106Endocytosis_Homo sapiens_hsa041440.50134071
107Thyroid hormone signaling pathway_Homo sapiens_hsa049190.49764723
108Pancreatic secretion_Homo sapiens_hsa049720.49566386
109Linoleic acid metabolism_Homo sapiens_hsa005910.49214652
110HTLV-I infection_Homo sapiens_hsa051660.49111800
111Nitrogen metabolism_Homo sapiens_hsa009100.49080550
112Steroid hormone biosynthesis_Homo sapiens_hsa001400.48886182
113Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.48866983
114Arachidonic acid metabolism_Homo sapiens_hsa005900.46829638
115Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.46430548
116Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.46042732
117HIF-1 signaling pathway_Homo sapiens_hsa040660.42723606
118Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.42639112
119Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.42075405
120FoxO signaling pathway_Homo sapiens_hsa040680.41895311
121mTOR signaling pathway_Homo sapiens_hsa041500.41498319
122Fat digestion and absorption_Homo sapiens_hsa049750.41364923
123Prion diseases_Homo sapiens_hsa050200.41303174
124Salmonella infection_Homo sapiens_hsa051320.40747470
125Selenocompound metabolism_Homo sapiens_hsa004500.40355751
126Cholinergic synapse_Homo sapiens_hsa047250.39966211
127Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.39733974
128Non-small cell lung cancer_Homo sapiens_hsa052230.39431854
129ErbB signaling pathway_Homo sapiens_hsa040120.39333089
130Circadian entrainment_Homo sapiens_hsa047130.39260807
131Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.38189546
132MAPK signaling pathway_Homo sapiens_hsa040100.38111254
133Phagosome_Homo sapiens_hsa041450.37972320

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