ITGAD

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene belongs to the beta-2 integrin family of membrane glycoproteins, which are are composed of non-covalently linked alpha and beta subunits to form a heterodimer. It encodes the alpha subunit of the cell surface heterodimers and is involved in the activation and adhesion functions of leukocytes. The gene is located about 11kb downstream of the integrin subunit alpha X gene, another member of the integrin family. It is expressed in the tissue and circulating myeloid leukocytes. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1central nervous system myelination (GO:0022010)8.61217533
2axon ensheathment in central nervous system (GO:0032291)8.61217533
3behavioral response to nicotine (GO:0035095)6.02762596
4axon ensheathment (GO:0008366)5.91822946
5ensheathment of neurons (GO:0007272)5.91822946
6myelination (GO:0042552)5.88754012
7fatty acid elongation (GO:0030497)5.42804449
8tryptophan catabolic process (GO:0006569)5.41041760
9indole-containing compound catabolic process (GO:0042436)5.41041760
10indolalkylamine catabolic process (GO:0046218)5.41041760
11negative regulation of neurotransmitter secretion (GO:0046929)5.18688422
12kynurenine metabolic process (GO:0070189)5.07493428
13glycerophospholipid catabolic process (GO:0046475)4.93466635
14long-chain fatty acid biosynthetic process (GO:0042759)4.65953199
15protein K11-linked deubiquitination (GO:0035871)4.63938127
16virion attachment to host cell (GO:0019062)4.59043610
17adhesion of symbiont to host cell (GO:0044650)4.59043610
18positive regulation of action potential (GO:0045760)4.53527045
19oligodendrocyte differentiation (GO:0048709)4.36763574
20sulfation (GO:0051923)4.28150974
21indolalkylamine metabolic process (GO:0006586)4.14223843
22tryptophan metabolic process (GO:0006568)4.11519897
23cellular biogenic amine catabolic process (GO:0042402)3.92186763
24amine catabolic process (GO:0009310)3.92186763
25presynaptic membrane assembly (GO:0097105)3.91241765
26leukocyte migration involved in inflammatory response (GO:0002523)3.89282997
27eye photoreceptor cell differentiation (GO:0001754)3.87245947
28photoreceptor cell differentiation (GO:0046530)3.87245947
29disruption of cells of other organism (GO:0044364)3.86708966
30killing of cells of other organism (GO:0031640)3.86708966
31negative regulation of neurotransmitter transport (GO:0051589)3.86645361
32positive regulation of oligodendrocyte differentiation (GO:0048714)3.80832776
33myelin maintenance (GO:0043217)3.79492863
34interferon-gamma production (GO:0032609)3.69390436
35astrocyte development (GO:0014002)3.64216103
36creatine metabolic process (GO:0006600)3.60049463
37asymmetric protein localization (GO:0008105)3.58673108
38L-fucose metabolic process (GO:0042354)3.55912397
39L-fucose catabolic process (GO:0042355)3.55912397
40fucose catabolic process (GO:0019317)3.55912397
41apical protein localization (GO:0045176)3.54641090
42adhesion of symbiont to host (GO:0044406)3.53136774
43histone H2B ubiquitination (GO:0033523)3.50442140
44presynaptic membrane organization (GO:0097090)3.47307604
45detection of light stimulus involved in sensory perception (GO:0050962)3.46340784
46detection of light stimulus involved in visual perception (GO:0050908)3.46340784
47synaptic transmission, cholinergic (GO:0007271)3.44265674
48cellular response to ATP (GO:0071318)3.43048974
49positive regulation of interleukin-17 production (GO:0032740)3.38649617
50neutrophil activation involved in immune response (GO:0002283)3.38649321
51sulfate transmembrane transport (GO:1902358)3.36572918
52response to lipoprotein particle (GO:0055094)3.35493579
53serotonin receptor signaling pathway (GO:0007210)3.34913551
54negative regulation of mast cell activation (GO:0033004)3.34401971
55protein-cofactor linkage (GO:0018065)3.31819141
56glycosylceramide metabolic process (GO:0006677)3.29406273
57negative regulation of interleukin-8 production (GO:0032717)3.28417961
58negative regulation of telomere maintenance (GO:0032205)3.27846518
59negative regulation of JUN kinase activity (GO:0043508)3.21620862
60defense response to fungus (GO:0050832)3.20165017
61Leydig cell differentiation (GO:0033327)3.18857856
62import into cell (GO:0098657)3.16812180
63membrane raft organization (GO:0031579)3.14304393
64NAD biosynthetic process (GO:0009435)3.12417177
65indole-containing compound metabolic process (GO:0042430)3.10297119
66positive regulation of CD4-positive, alpha-beta T cell activation (GO:2000516)3.09588941
67detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.09330558
68positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.08946385
69positive regulation of glial cell differentiation (GO:0045687)3.08168160
70superoxide anion generation (GO:0042554)3.05956272
71nephron tubule morphogenesis (GO:0072078)3.05631454
72nephron epithelium morphogenesis (GO:0072088)3.05631454
73peptidyl-tyrosine autophosphorylation (GO:0038083)3.02474884
74cholesterol biosynthetic process (GO:0006695)3.02410676
75neuron fate determination (GO:0048664)2.98293448
76negative regulation of protein localization to cell surface (GO:2000009)2.97843310
77protein palmitoylation (GO:0018345)2.97426816
78magnesium ion transport (GO:0015693)2.96907432
79sulfate transport (GO:0008272)2.93447703
80mucosal immune response (GO:0002385)2.90665528
81regulation of appetite (GO:0032098)2.89942966
82membrane assembly (GO:0071709)2.86472151
83response to redox state (GO:0051775)2.83874119
84regulation of homotypic cell-cell adhesion (GO:0034110)2.82497034
85regulation of collateral sprouting (GO:0048670)2.82301873
86nerve growth factor signaling pathway (GO:0038180)2.81526081
87preassembly of GPI anchor in ER membrane (GO:0016254)2.81200404
88rRNA catabolic process (GO:0016075)2.79887588
89GPI anchor biosynthetic process (GO:0006506)2.79835256
90positive regulation of T-helper cell differentiation (GO:0045624)2.78556724
91substantia nigra development (GO:0021762)2.77633474
92positive regulation of gliogenesis (GO:0014015)2.77532060
93regulation of nitric-oxide synthase biosynthetic process (GO:0051769)2.76805787
94organ or tissue specific immune response (GO:0002251)2.76731978
95neuronal action potential (GO:0019228)2.76579684
96epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.75064266
97cellular ketone body metabolic process (GO:0046950)2.74911958
98negative regulation of acute inflammatory response (GO:0002674)2.74290273
99cellular response to hepatocyte growth factor stimulus (GO:0035729)2.73896122
100response to hepatocyte growth factor (GO:0035728)2.73896122
101startle response (GO:0001964)2.72477868
102cellular response to epinephrine stimulus (GO:0071872)2.72306218
103cAMP catabolic process (GO:0006198)2.71998714
104regulation of action potential (GO:0098900)2.71949114
105negative regulation of inclusion body assembly (GO:0090084)2.71210993
106regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.70886527
107interleukin-6-mediated signaling pathway (GO:0070102)2.70505544
108alkaloid metabolic process (GO:0009820)2.69977898
109phosphatidylinositol acyl-chain remodeling (GO:0036149)2.69830480
110negative regulation of myoblast differentiation (GO:0045662)2.68848150
111Rap protein signal transduction (GO:0032486)2.68377101
112multicellular organism reproduction (GO:0032504)2.66750649
113positive regulation of fatty acid transport (GO:2000193)2.64738960
114cyclic nucleotide catabolic process (GO:0009214)2.63605885
115regulation of CD4-positive, alpha-beta T cell activation (GO:2000514)2.63233608
116transmission of nerve impulse (GO:0019226)2.62545582
117reflex (GO:0060004)2.62460580
118amyloid precursor protein catabolic process (GO:0042987)2.62435174
119nucleotide transmembrane transport (GO:1901679)2.62163877
120cilium or flagellum-dependent cell motility (GO:0001539)2.61952208
121respiratory burst (GO:0045730)2.61664628
122amyloid precursor protein metabolic process (GO:0042982)2.61157965
123hematopoietic stem cell proliferation (GO:0071425)2.60502042
124regulation of interleukin-17 production (GO:0032660)2.59850367
125positive regulation of T-helper 1 type immune response (GO:0002827)2.59827227
126positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)2.59792513
127response to nerve growth factor (GO:1990089)2.59361684
128cellular response to nerve growth factor stimulus (GO:1990090)2.59361684
129gamma-aminobutyric acid transport (GO:0015812)2.59327666
130nicotinamide nucleotide biosynthetic process (GO:0019359)2.59285828
131pyridine nucleotide biosynthetic process (GO:0019363)2.59285828
132negative regulation of reactive oxygen species metabolic process (GO:2000378)2.58340742
133myelination in peripheral nervous system (GO:0022011)2.58095187
134peripheral nervous system axon ensheathment (GO:0032292)2.58095187
135positive regulation of defense response to virus by host (GO:0002230)2.57680365
136negative regulation of mesenchymal cell apoptotic process (GO:2001054)2.57350569
137leukocyte aggregation (GO:0070486)2.56414513
138positive regulation of cell fate commitment (GO:0010455)2.55268113
139GPI anchor metabolic process (GO:0006505)2.55022160
140intracellular pH reduction (GO:0051452)2.54887721
141regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)2.54169455
142cysteine metabolic process (GO:0006534)2.53573145
143regulation of memory T cell differentiation (GO:0043380)2.52872848
144limb bud formation (GO:0060174)2.52095305
145regulation of interleukin-6 biosynthetic process (GO:0045408)2.52012219
146positive regulation of cellular amine metabolic process (GO:0033240)2.51913632
147axon development (GO:0061564)2.51910956
148cerebral cortex radially oriented cell migration (GO:0021799)2.51753699
149B cell receptor signaling pathway (GO:0050853)2.49439659
150fusion of sperm to egg plasma membrane (GO:0007342)2.49099906
151negative regulation of peptidyl-threonine phosphorylation (GO:0010801)2.48464613
152positive regulation of toll-like receptor signaling pathway (GO:0034123)2.48172491
153exogenous drug catabolic process (GO:0042738)2.47815854
154sterol biosynthetic process (GO:0016126)2.47238836
155positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)2.46514791
156membrane protein ectodomain proteolysis (GO:0006509)2.45803929
157glial cell development (GO:0021782)2.45543063
158negative regulation of exocytosis (GO:0045920)2.43905982
159regulation of platelet aggregation (GO:0090330)2.43904246
160primary amino compound metabolic process (GO:1901160)2.43090191
161ear development (GO:0043583)2.43061907
162regulation of T-helper cell differentiation (GO:0045622)2.42280052
163aromatic amino acid family catabolic process (GO:0009074)2.40494737
164positive regulation of hair follicle development (GO:0051798)2.39793433
165positive regulation of hair cycle (GO:0042635)2.39793433
166organic cation transport (GO:0015695)2.39282859
167sequestering of actin monomers (GO:0042989)2.38731910
168tolerance induction (GO:0002507)2.37170732
169ketone body metabolic process (GO:1902224)2.36959336
170benzene-containing compound metabolic process (GO:0042537)2.35450736
171urinary tract smooth muscle contraction (GO:0014848)2.33686786
172positive regulation of prostaglandin secretion (GO:0032308)2.32808847
173RNA destabilization (GO:0050779)2.32109349
174phosphatidylethanolamine acyl-chain remodeling (GO:0036152)2.31606278
175purinergic nucleotide receptor signaling pathway (GO:0035590)2.30780153
176positive regulation of phosphoprotein phosphatase activity (GO:0032516)2.29126294
177neural tube formation (GO:0001841)2.27893494
178endoderm formation (GO:0001706)2.27585794
179positive regulation of cAMP-mediated signaling (GO:0043950)2.27017354
180regulation of mesenchymal cell apoptotic process (GO:2001053)2.26836640
181negative regulation by host of viral transcription (GO:0043922)2.25271413
182negative regulation of interleukin-1 production (GO:0032692)2.23680518
183alanine transport (GO:0032328)2.22935162
184negative regulation of systemic arterial blood pressure (GO:0003085)2.22330443
185renal tubule morphogenesis (GO:0061333)2.21651405
186rhodopsin mediated signaling pathway (GO:0016056)2.21565731
187pyrimidine nucleobase catabolic process (GO:0006208)2.21179402
188cellular response to interferon-beta (GO:0035458)2.19443060
189positive regulation of icosanoid secretion (GO:0032305)2.18487962
190drug catabolic process (GO:0042737)2.17309176
191response to fungus (GO:0009620)2.16957494
192NADH dehydrogenase complex assembly (GO:0010257)2.16898075
193mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.16898075

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.27126676
2FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.49614201
3ZNF274_21170338_ChIP-Seq_K562_Hela3.23940803
4HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse3.12621361
5GBX2_23144817_ChIP-Seq_PC3_Human2.91043497
6VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.78047414
7E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.57477578
8TAF15_26573619_Chip-Seq_HEK293_Human2.35185620
9IRF8_21731497_ChIP-ChIP_J774_Mouse2.26260025
10TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.04615053
11SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse2.01946800
12ZFP57_27257070_Chip-Seq_ESCs_Mouse1.98627637
13CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.93300382
14IGF1R_20145208_ChIP-Seq_DFB_Human1.87691463
15POU3F2_20337985_ChIP-ChIP_501MEL_Human1.86445965
16GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.86369244
17REST_21632747_ChIP-Seq_MESCs_Mouse1.77927675
18ER_23166858_ChIP-Seq_MCF-7_Human1.77018687
19IKZF1_21737484_ChIP-ChIP_HCT116_Human1.75931455
20IRF1_19129219_ChIP-ChIP_H3396_Human1.66668510
21AR_21572438_ChIP-Seq_LNCaP_Human1.66299600
22STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.64363234
23NOTCH1_21737748_ChIP-Seq_TLL_Human1.63754874
24PCGF2_27294783_Chip-Seq_NPCs_Mouse1.62518050
25IRF8_27001747_Chip-Seq_BMDM_Mouse1.60602902
26SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.60460675
27EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.56820573
28RUNX_20019798_ChIP-Seq_JUKART_Human1.56433958
29PCGF2_27294783_Chip-Seq_ESCs_Mouse1.54223310
30CMYC_18555785_Chip-Seq_ESCs_Mouse1.52559360
31CTBP2_25329375_ChIP-Seq_LNCAP_Human1.51801136
32GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.50572504
33OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.49629781
34IRF8_22096565_ChIP-ChIP_GC-B_Human1.48268598
35NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.47052166
36NANOG_18555785_Chip-Seq_ESCs_Mouse1.44158340
37CDX2_19796622_ChIP-Seq_MESCs_Mouse1.43163497
38SUZ12_18555785_Chip-Seq_ESCs_Mouse1.43013607
39SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.42385434
40FLI1_27457419_Chip-Seq_LIVER_Mouse1.41540459
41EED_16625203_ChIP-ChIP_MESCs_Mouse1.41475148
42TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.37938719
43P300_18555785_Chip-Seq_ESCs_Mouse1.37869178
44ETV2_25802403_ChIP-Seq_MESCs_Mouse1.37480715
45TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.37452950
46GATA3_21878914_ChIP-Seq_MCF-7_Human1.36952805
47CBX2_27304074_Chip-Seq_ESCs_Mouse1.36248046
48EZH2_27294783_Chip-Seq_NPCs_Mouse1.35176993
49WT1_19549856_ChIP-ChIP_CCG9911_Human1.34745384
50IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.33480506
51EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.33330264
52SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.32110981
53JARID2_20075857_ChIP-Seq_MESCs_Mouse1.32009894
54PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.31981013
55DROSHA_22980978_ChIP-Seq_HELA_Human1.31456181
56P53_22387025_ChIP-Seq_ESCs_Mouse1.31012680
57SUZ12_27294783_Chip-Seq_NPCs_Mouse1.30565402
58ERA_21632823_ChIP-Seq_H3396_Human1.30378203
59EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.28851227
60SUZ12_27294783_Chip-Seq_ESCs_Mouse1.27306107
61BP1_19119308_ChIP-ChIP_Hs578T_Human1.27098632
62VDR_24787735_ChIP-Seq_THP-1_Human1.26470937
63TAL1_26923725_Chip-Seq_HPCs_Mouse1.26305687
64JARID2_20064375_ChIP-Seq_MESCs_Mouse1.25859747
65BCAT_22108803_ChIP-Seq_LS180_Human1.25785634
66TP53_22573176_ChIP-Seq_HFKS_Human1.25432549
67Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.25030892
68NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.24615434
69SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.23505023
70EWS_26573619_Chip-Seq_HEK293_Human1.22926218
71MTF2_20144788_ChIP-Seq_MESCs_Mouse1.21735174
72UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.21700188
73SOX2_18555785_Chip-Seq_ESCs_Mouse1.21603770
74FUS_26573619_Chip-Seq_HEK293_Human1.21466478
75STAT3_18555785_Chip-Seq_ESCs_Mouse1.20257376
76BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.20166415
77MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.20153197
78PIAS1_25552417_ChIP-Seq_VCAP_Human1.20142929
79SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.19860075
80SMAD1_18555785_Chip-Seq_ESCs_Mouse1.19815043
81RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.19750321
82EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.19258645
83VDR_22108803_ChIP-Seq_LS180_Human1.18800750
84AR_25329375_ChIP-Seq_VCAP_Human1.18746507
85AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.18730404
86NFE2_27457419_Chip-Seq_LIVER_Mouse1.18641544
87SMAD3_21741376_ChIP-Seq_EPCs_Human1.18172481
88SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.16878373
89E2F1_18555785_Chip-Seq_ESCs_Mouse1.16221059
90SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.15797852
91EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.15682334
92EZH2_27294783_Chip-Seq_ESCs_Mouse1.15642633
93KLF4_18555785_Chip-Seq_ESCs_Mouse1.14971680
94IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.14670280
95CBP_20019798_ChIP-Seq_JUKART_Human1.14670280
96CTBP1_25329375_ChIP-Seq_LNCAP_Human1.14590857
97RUNX1_27457419_Chip-Seq_LIVER_Mouse1.14581822
98P300_19829295_ChIP-Seq_ESCs_Human1.14459809
99P53_22127205_ChIP-Seq_FIBROBLAST_Human1.14238100
100MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.14212076
101BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.13539139
102KDM2B_26808549_Chip-Seq_REH_Human1.11953763
103NMYC_18555785_Chip-Seq_ESCs_Mouse1.11454403
104STAT3_23295773_ChIP-Seq_U87_Human1.11401632
105NANOG_20526341_ChIP-Seq_ESCs_Human1.11326756
106FOXA1_25329375_ChIP-Seq_VCAP_Human1.10438695
107FOXA1_27270436_Chip-Seq_PROSTATE_Human1.10438695
108OCT4_18555785_Chip-Seq_ESCs_Mouse1.10311138
109SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.10104554
110WDR5_24793694_ChIP-Seq_LNCAP_Human1.08843142
111RNF2_27304074_Chip-Seq_NSC_Mouse1.08766547
112PU1_27457419_Chip-Seq_LIVER_Mouse1.08539374
113FLI1_21867929_ChIP-Seq_TH2_Mouse1.08248309
114CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.07988545
115CRX_20693478_ChIP-Seq_RETINA_Mouse1.07835438
116MYC_19829295_ChIP-Seq_ESCs_Human1.07683814
117RUNX2_22187159_ChIP-Seq_PCA_Human1.07398911
118FOXH1_21741376_ChIP-Seq_ESCs_Human1.07047810
119TCF4_23295773_ChIP-Seq_U87_Human1.06246967
120RNF2_18974828_ChIP-Seq_MESCs_Mouse1.05103440
121EZH2_18974828_ChIP-Seq_MESCs_Mouse1.05103440
122SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.05027677
123TAF2_19829295_ChIP-Seq_ESCs_Human1.05019809
124IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.04086247
125LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.03746968
126PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.03679114
127REST_18959480_ChIP-ChIP_MESCs_Mouse1.03543411
128NCOR_22424771_ChIP-Seq_293T_Human1.02838170
129POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.02791316
130TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.02791316
131CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.01961187
132RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.01894833
133ZFX_18555785_Chip-Seq_ESCs_Mouse1.01803412
134FOXH1_21741376_ChIP-Seq_EPCs_Human1.01426292
135SMAD4_21741376_ChIP-Seq_EPCs_Human1.01301162
136SCL_19346495_ChIP-Seq_HPC-7_Human1.00729167
137TBL1_22424771_ChIP-Seq_293T_Human1.00700742
138PRDM14_20953172_ChIP-Seq_ESCs_Human1.00268700
139RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.00065614
140PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.98878034
141PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.97477572
142HOXB7_26014856_ChIP-Seq_BT474_Human0.96105267
143BMI1_23680149_ChIP-Seq_NPCS_Mouse0.95732302
144NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.95513071
145NRF2_20460467_ChIP-Seq_MEFs_Mouse0.95513071
146STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.95495121
147RNF2_27304074_Chip-Seq_ESCs_Mouse0.95465883
148CTCF_18555785_Chip-Seq_ESCs_Mouse0.95188783
149EZH2_27304074_Chip-Seq_ESCs_Mouse0.95108236
150GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.94307200
151ESRRB_18555785_Chip-Seq_ESCs_Mouse0.94168694
152TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.93995835
153NR3C1_21868756_ChIP-Seq_MCF10A_Human0.93377605
154SMAD4_21799915_ChIP-Seq_A2780_Human0.91590037
155HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.91546357
156OCT4_20526341_ChIP-Seq_ESCs_Human0.91311505
157E2F1_20622854_ChIP-Seq_HELA_Human0.89226378
158FOXA1_21572438_ChIP-Seq_LNCaP_Human0.88597479
159EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.86062652
160CTCF_20526341_ChIP-Seq_ESCs_Human0.85948442

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000920_abnormal_myelination5.36705451
2MP0003690_abnormal_glial_cell3.71734654
3MP0003950_abnormal_plasma_membrane3.33756007
4MP0003136_yellow_coat_color3.05065611
5MP0005410_abnormal_fertilization2.77275555
6MP0003880_abnormal_central_pattern2.62783769
7MP0004270_analgesia2.52027708
8MP0001968_abnormal_touch/_nociception2.49650181
9MP0003646_muscle_fatigue2.45903310
10MP0000569_abnormal_digit_pigmentation2.44608343
11MP0006082_CNS_inflammation2.34517248
12MP0008875_abnormal_xenobiotic_pharmacok2.32356645
13MP0005451_abnormal_body_composition2.30373301
14MP0002653_abnormal_ependyma_morphology2.23012107
15MP0005171_absent_coat_pigmentation2.22125121
16MP0002736_abnormal_nociception_after2.20423779
17MP0004742_abnormal_vestibular_system2.19381049
18MP0001835_abnormal_antigen_presentation2.17941257
19MP0004130_abnormal_muscle_cell2.13376587
20MP0005409_darkened_coat_color2.08381500
21MP0003634_abnormal_glial_cell2.08104596
22* MP0001790_abnormal_immune_system2.04718085
23* MP0005387_immune_system_phenotype2.04718085
24MP0005000_abnormal_immune_tolerance2.03873173
25MP0001905_abnormal_dopamine_level2.03700956
26MP0006276_abnormal_autonomic_nervous2.00688940
27MP0005671_abnormal_response_to1.94912587
28MP0002148_abnormal_hypersensitivity_rea1.90660029
29MP0002138_abnormal_hepatobiliary_system1.89643513
30MP0003724_increased_susceptibility_to1.83025554
31MP0000383_abnormal_hair_follicle1.80117822
32MP0004147_increased_porphyrin_level1.73297908
33* MP0002419_abnormal_innate_immunity1.72522237
34MP0002928_abnormal_bile_duct1.70755520
35MP0002277_abnormal_respiratory_mucosa1.68253776
36MP0004381_abnormal_hair_follicle1.66840807
37MP0001919_abnormal_reproductive_system1.63703573
38MP0009785_altered_susceptibility_to1.63649609
39MP0004145_abnormal_muscle_electrophysio1.63470215
40MP0005084_abnormal_gallbladder_morpholo1.61442808
41MP0004885_abnormal_endolymph1.58951339
42MP0005377_hearing/vestibular/ear_phenot1.58421904
43MP0003878_abnormal_ear_physiology1.58421904
44MP0001346_abnormal_lacrimal_gland1.56976518
45MP0003329_amyloid_beta_deposits1.56427038
46MP0005310_abnormal_salivary_gland1.56414662
47MP0008260_abnormal_autophagy1.56264045
48MP0008057_abnormal_DNA_replication1.55745325
49* MP0005025_abnormal_response_to1.54108607
50* MP0002723_abnormal_immune_serum1.53682315
51MP0001800_abnormal_humoral_immune1.53265847
52MP0002638_abnormal_pupillary_reflex1.49390895
53MP0002837_dystrophic_cardiac_calcinosis1.49250635
54MP0001501_abnormal_sleep_pattern1.49017167
55MP0005058_abnormal_lysosome_morphology1.47022289
56MP0002229_neurodegeneration1.46558765
57MP0000685_abnormal_immune_system1.46513608
58MP0005423_abnormal_somatic_nervous1.46055125
59MP0001486_abnormal_startle_reflex1.45452048
60MP0010678_abnormal_skin_adnexa1.45432303
61MP0001986_abnormal_taste_sensitivity1.44129339
62MP0001348_abnormal_lacrimal_gland1.43403684
63MP0002272_abnormal_nervous_system1.42809559
64MP0001851_eye_inflammation1.42386218
65* MP0002452_abnormal_antigen_presenting1.42121109
66MP0004510_myositis1.38897908
67MP0002572_abnormal_emotion/affect_behav1.37935120
68MP0004142_abnormal_muscle_tone1.37686381
69MP0001485_abnormal_pinna_reflex1.35511166
70MP0008872_abnormal_physiological_respon1.35265312
71MP0001970_abnormal_pain_threshold1.34278846
72MP0003632_abnormal_nervous_system1.34081470
73MP0001529_abnormal_vocalization1.33849196
74* MP0002420_abnormal_adaptive_immunity1.32004574
75MP0002933_joint_inflammation1.31525442
76* MP0001819_abnormal_immune_cell1.29627213
77MP0004133_heterotaxia1.28605145
78MP0003183_abnormal_peptide_metabolism1.28147005
79MP0002876_abnormal_thyroid_physiology1.25962066
80MP0005389_reproductive_system_phenotype1.24603506
81MP0001727_abnormal_embryo_implantation1.23902062
82MP0002064_seizures1.23689833
83MP0000566_synostosis1.23633947
84MP0005174_abnormal_tail_pigmentation1.23559732
85MP0009764_decreased_sensitivity_to1.21188071
86MP0003252_abnormal_bile_duct1.19784071
87MP0002102_abnormal_ear_morphology1.19188103
88MP0000604_amyloidosis1.18967866
89MP0000778_abnormal_nervous_system1.17470445
90MP0000465_gastrointestinal_hemorrhage1.14691470
91MP0000462_abnormal_digestive_system1.13198385
92MP0001963_abnormal_hearing_physiology1.13065697
93MP0005167_abnormal_blood-brain_barrier1.12954391
94MP0005448_abnormal_energy_balance1.11956823
95MP0002733_abnormal_thermal_nociception1.11585807
96MP0005085_abnormal_gallbladder_physiolo1.11194236
97MP0001299_abnormal_eye_distance/1.11073109
98MP0002063_abnormal_learning/memory/cond1.10688298
99MP0000230_abnormal_systemic_arterial1.09121206
100MP0002557_abnormal_social/conspecific_i1.06989899
101MP0004134_abnormal_chest_morphology1.06594986
102MP0002734_abnormal_mechanical_nocicepti1.06074094
103MP0003635_abnormal_synaptic_transmissio1.05764502
104MP0008877_abnormal_DNA_methylation1.05447619
105MP0006292_abnormal_olfactory_placode1.04576465
106MP0000372_irregular_coat_pigmentation1.03919939
107MP0009046_muscle_twitch1.02385857
108MP0002735_abnormal_chemical_nociception1.00951578
109MP0003195_calcinosis1.00172892
110MP0000631_abnormal_neuroendocrine_gland0.99971280
111MP0003011_delayed_dark_adaptation0.99326776
112MP0005253_abnormal_eye_physiology0.96679155
113MP0002139_abnormal_hepatobiliary_system0.96317509
114MP0008995_early_reproductive_senescence0.93871489
115MP0003787_abnormal_imprinting0.88989428
116MP0005408_hypopigmentation0.88719958
117* MP0000716_abnormal_immune_system0.88597931
118MP0005195_abnormal_posterior_eye0.87638995
119MP0001440_abnormal_grooming_behavior0.86810869
120MP0009745_abnormal_behavioral_response0.86275056
121MP0002405_respiratory_system_inflammati0.86077519
122MP0003045_fibrosis0.85114679
123MP0000955_abnormal_spinal_cord0.85090575
124MP0001873_stomach_inflammation0.84619728
125MP0003638_abnormal_response/metabolism_0.84169070
126MP0005645_abnormal_hypothalamus_physiol0.83991862
127MP0000470_abnormal_stomach_morphology0.80649469
128MP0009379_abnormal_foot_pigmentation0.80629887
129MP0000427_abnormal_hair_cycle0.77848959
130MP0005551_abnormal_eye_electrophysiolog0.77751105
131MP0001663_abnormal_digestive_system0.77646558
132MP0005379_endocrine/exocrine_gland_phen0.77004567
133MP0008438_abnormal_cutaneous_collagen0.76314169
134MP0005623_abnormal_meninges_morphology0.76128806
135MP0005535_abnormal_body_temperature0.76047595
136MP0002882_abnormal_neuron_morphology0.74457602
137MP0003303_peritoneal_inflammation0.73161355
138MP0005464_abnormal_platelet_physiology0.72579601
139MP0004036_abnormal_muscle_relaxation0.72336207
140MP0002295_abnormal_pulmonary_circulatio0.70668997
141MP0005388_respiratory_system_phenotype0.70190366
142MP0002133_abnormal_respiratory_system0.70190366
143MP0003631_nervous_system_phenotype0.70177774
144MP0001502_abnormal_circadian_rhythm0.69218525
145MP0005386_behavior/neurological_phenoty0.69008004
146MP0004924_abnormal_behavior0.69008004
147MP0002066_abnormal_motor_capabilities/c0.67431828
148MP0001661_extended_life_span0.67048829
149MP0002752_abnormal_somatic_nervous0.66932673
150MP0004043_abnormal_pH_regulation0.65991372
151MP0003436_decreased_susceptibility_to0.65614733
152MP0000026_abnormal_inner_ear0.64795057
153MP0010386_abnormal_urinary_bladder0.64233397
154MP0002067_abnormal_sensory_capabilities0.63532429

Predicted human phenotypes

RankGene SetZ-score
1Sensory axonal neuropathy (HP:0003390)5.75674158
2Parakeratosis (HP:0001036)5.21649164
3Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)5.17447801
4Degeneration of the lateral corticospinal tracts (HP:0002314)5.17447801
5Neurofibrillary tangles (HP:0002185)4.74321784
6Congenital stationary night blindness (HP:0007642)4.52652022
7Congenital nonbullous ichthyosiform erythroderma (HP:0007479)4.26182410
8Akinesia (HP:0002304)3.96289830
9Molar tooth sign on MRI (HP:0002419)3.94856905
10Abnormality of midbrain morphology (HP:0002418)3.94856905
11Attenuation of retinal blood vessels (HP:0007843)3.85135003
12Absent/shortened dynein arms (HP:0200106)3.71128966
13Dynein arm defect of respiratory motile cilia (HP:0012255)3.71128966
14Pancreatic cysts (HP:0001737)3.69348276
15True hermaphroditism (HP:0010459)3.66550819
16Respiratory insufficiency due to defective ciliary clearance (HP:0200073)3.45450849
17Abnormality of the corticospinal tract (HP:0002492)3.45121462
18Abnormal ciliary motility (HP:0012262)3.36847759
19Pancreatic fibrosis (HP:0100732)3.35921691
20Hyperventilation (HP:0002883)3.32763308
21Supranuclear gaze palsy (HP:0000605)3.30633625
22Chronic hepatic failure (HP:0100626)3.20923313
23Nephronophthisis (HP:0000090)3.20812208
24Abnormal respiratory motile cilium physiology (HP:0012261)3.17699692
25Type II lissencephaly (HP:0007260)3.15082990
26Peripheral hypomyelination (HP:0007182)3.13709683
27Congenital ichthyosiform erythroderma (HP:0007431)3.10652156
28Hepatosplenomegaly (HP:0001433)2.99271312
29Slow saccadic eye movements (HP:0000514)2.98236978
30Cerebral inclusion bodies (HP:0100314)2.96669141
31Onion bulb formation (HP:0003383)2.92897997
32Chronic otitis media (HP:0000389)2.85505292
33Myositis (HP:0100614)2.79220734
34Abnormal respiratory epithelium morphology (HP:0012253)2.78603489
35Abnormal respiratory motile cilium morphology (HP:0005938)2.78603489
36Orchitis (HP:0100796)2.77018849
37Split foot (HP:0001839)2.74136471
38Abnormal number of erythroid precursors (HP:0012131)2.73799987
39Spastic gait (HP:0002064)2.73450125
40Large for gestational age (HP:0001520)2.69242146
41Recurrent abscess formation (HP:0002722)2.68724065
42Decreased central vision (HP:0007663)2.66505961
43Cerebellar dysplasia (HP:0007033)2.65954263
44Tetany (HP:0001281)2.64364483
45Abnormality of the renal medulla (HP:0100957)2.63386544
46Bony spicule pigmentary retinopathy (HP:0007737)2.60134015
47Hypomagnesemia (HP:0002917)2.58985206
48Recurrent skin infections (HP:0001581)2.57826500
49Abnormality of DNA repair (HP:0003254)2.57416124
50Polydipsia (HP:0001959)2.56699072
51Congenital, generalized hypertrichosis (HP:0004540)2.55943677
52Alacrima (HP:0000522)2.54449664
53Purpura (HP:0000979)2.53906946
54Autoamputation (HP:0001218)2.53365552
55Clumsiness (HP:0002312)2.53349739
56Abnormality of alanine metabolism (HP:0010916)2.51817938
57Hyperalaninemia (HP:0003348)2.51817938
58Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.51817938
59Increased neuronal autofluorescent lipopigment (HP:0002074)2.51334365
60Intention tremor (HP:0002080)2.51163878
61Stridor (HP:0010307)2.48550285
62Abnormality of cells of the erythroid lineage (HP:0012130)2.48510081
63Spastic paraparesis (HP:0002313)2.48115835
64Abnormal rod and cone electroretinograms (HP:0008323)2.47651394
65Progressive cerebellar ataxia (HP:0002073)2.47379020
66Poikiloderma (HP:0001029)2.47370728
67Gastrointestinal stroma tumor (HP:0100723)2.44019696
68Decreased electroretinogram (ERG) amplitude (HP:0000654)2.43691716
693-Methylglutaconic aciduria (HP:0003535)2.42056637
70Thickened helices (HP:0000391)2.41760355
71Abnormality of macrophages (HP:0004311)2.41586734
72Mesangial abnormality (HP:0001966)2.40066641
73Anteriorly placed anus (HP:0001545)2.39271466
74Abnormality of the renal cortex (HP:0011035)2.38790919
75Decreased circulating renin level (HP:0003351)2.34876118
76Type 2 muscle fiber atrophy (HP:0003554)2.34532248
77Adrenal hypoplasia (HP:0000835)2.33854308
78Dysmetria (HP:0001310)2.32576862
79Keratoconjunctivitis (HP:0001096)2.32489401
80Abnormal biliary tract physiology (HP:0012439)2.31728629
81Bile duct proliferation (HP:0001408)2.31728629
82Absent speech (HP:0001344)2.30632831
83Barrel-shaped chest (HP:0001552)2.29255291
84Decreased lacrimation (HP:0000633)2.29208563
85Medial flaring of the eyebrow (HP:0010747)2.25976622
86Abnormal auditory evoked potentials (HP:0006958)2.25841531
87Rib fusion (HP:0000902)2.25814807
88Prolonged neonatal jaundice (HP:0006579)2.25183622
89Erythroderma (HP:0001019)2.24870672
90Recurrent sinusitis (HP:0011108)2.23289895
91Abnormality of the pons (HP:0007361)2.23148353
92Male pseudohermaphroditism (HP:0000037)2.22437275
93Chronic obstructive pulmonary disease (HP:0006510)2.20656890
94Obstructive lung disease (HP:0006536)2.20656890
95Stomatitis (HP:0010280)2.20101426
96Absent rod-and cone-mediated responses on ERG (HP:0007688)2.18254904
97Fair hair (HP:0002286)2.17946255
98Recurrent bacterial skin infections (HP:0005406)2.17209442
99Methylmalonic acidemia (HP:0002912)2.16565231
100Pendular nystagmus (HP:0012043)2.16398020
101Tubular atrophy (HP:0000092)2.16288327
102Inability to walk (HP:0002540)2.15904601
103Vacuolated lymphocytes (HP:0001922)2.15048835
104Cerebral hemorrhage (HP:0001342)2.14273145
105Hypoplasia of the pons (HP:0012110)2.13669585
106Premature skin wrinkling (HP:0100678)2.12828140
107Asplenia (HP:0001746)2.12704251
108Cystic liver disease (HP:0006706)2.12565596
109Small epiphyses (HP:0010585)2.12424606
110Hypoplastic pelvis (HP:0008839)2.12037916
111Agammaglobulinemia (HP:0004432)2.08202372
112Increased cerebral lipofuscin (HP:0011813)2.06304609
113Genetic anticipation (HP:0003743)2.05236455
114Polyuria (HP:0000103)2.04867761
115Abnormality of liposaccharide metabolism (HP:0010968)2.04210686
116Abnormality of glycosphingolipid metabolism (HP:0004343)2.04210686
117Abnormality of glycolipid metabolism (HP:0010969)2.04210686
118Cerebral hypomyelination (HP:0006808)2.03644108
119Focal motor seizures (HP:0011153)2.02133155
120Panhypogammaglobulinemia (HP:0003139)2.01537419
121Rhinitis (HP:0012384)2.01037411
122Visual hallucinations (HP:0002367)1.99687919
123Arthropathy (HP:0003040)1.97830098
124Concave nail (HP:0001598)1.97818096
125Severe muscular hypotonia (HP:0006829)1.97313830
126Limb dystonia (HP:0002451)1.96503947
127Recurrent pneumonia (HP:0006532)1.94495065
128Chronic mucocutaneous candidiasis (HP:0002728)1.94437497
129Recurrent cutaneous fungal infections (HP:0011370)1.94437497
130Protruding tongue (HP:0010808)1.94379010
131Vasculitis (HP:0002633)1.93981038
132Eczematoid dermatitis (HP:0000976)1.93215518
133Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.93184509
134Diminished movement (HP:0002374)1.92028714
135T lymphocytopenia (HP:0005403)1.91862012
136Aplasia/Hypoplasia of the patella (HP:0006498)1.90853590
137Bell-shaped thorax (HP:0001591)1.89308918
138Patellar aplasia (HP:0006443)1.88762169
139Absent septum pellucidum (HP:0001331)1.88367539
140Keratoconjunctivitis sicca (HP:0001097)1.87143351
141Generalized hypopigmentation of hair (HP:0011358)1.87072652
142Hypochromic microcytic anemia (HP:0004840)1.86605220
143Optic neuritis (HP:0100653)1.86313698
144Retrobulbar optic neuritis (HP:0100654)1.86313698
145Aplasia/Hypoplasia of the spleen (HP:0010451)1.86299532
146Congenital hepatic fibrosis (HP:0002612)1.84281758
147Optic disc pallor (HP:0000543)1.83632526
148Scanning speech (HP:0002168)1.83023406
149Abnormality of T cell number (HP:0011839)1.82138314
150Duplicated collecting system (HP:0000081)1.82011954
151Furrowed tongue (HP:0000221)1.81642981
152Lissencephaly (HP:0001339)1.81130329
153Xerostomia (HP:0000217)1.80994000
154Abnormality of the renal collecting system (HP:0004742)1.79847859
155Muscle fiber atrophy (HP:0100295)1.79138248
156Conical tooth (HP:0000698)1.78176388
157Myelomeningocele (HP:0002475)1.78133067
158J-shaped sella turcica (HP:0002680)1.78117059
159Abnormality of magnesium homeostasis (HP:0004921)1.78065364
160Anencephaly (HP:0002323)1.77041473
161Recurrent viral infections (HP:0004429)1.76501001
162Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.76463401
163Hypoplasia of the iris (HP:0007676)1.76247349
164Abnormality of the pericardium (HP:0001697)1.75786678
165Recurrent fungal infections (HP:0002841)1.75145064
166Spastic tetraparesis (HP:0001285)1.74705145
167Partial duplication of thumb phalanx (HP:0009944)1.73188553
168Meningitis (HP:0001287)1.72817926
169Keratitis (HP:0000491)1.72753525
170Hypoplasia of the capital femoral epiphysis (HP:0003090)1.72601655
171Anhidrosis (HP:0000970)1.72253183
172Congenital sensorineural hearing impairment (HP:0008527)1.70771102
173Bilateral microphthalmos (HP:0007633)1.69617292
174Hemoptysis (HP:0002105)1.69490270
175Cupped ear (HP:0000378)1.69058639
176Paraparesis (HP:0002385)1.68925115
177Agitation (HP:0000713)1.68453063
178Abnormality of the neuromuscular junction (HP:0003398)1.68256615
179Fatigable weakness (HP:0003473)1.68256615
180Abolished electroretinogram (ERG) (HP:0000550)1.67899737
181White forelock (HP:0002211)1.67739394
182Chronic sinusitis (HP:0011109)1.67568252
183Stomach cancer (HP:0012126)1.67530436
184Abnormal drinking behavior (HP:0030082)1.66916221

Predicted kinase interactions (KEA)

RankGene SetZ-score
1STK396.45403622
2OXSR14.33730858
3FRK4.10500380
4WNK32.82424152
5TLK12.77957352
6PINK12.71214559
7WNK42.70137600
8WNK12.62307942
9EPHB12.40025123
10MAP4K12.39065622
11PRPF4B2.39060923
12CDK192.30135295
13MST42.27291594
14PBK2.12124945
15PKN12.07598130
16MET2.05994286
17TNIK1.98772307
18BCR1.97096528
19ZAK1.96097415
20SIK21.95987143
21FGFR21.86815796
22MAP3K141.85170801
23TAOK31.82526847
24DAPK21.76534586
25IRAK21.74090345
26MAPK131.71014533
27MAP3K111.65269161
28ICK1.63234368
29FGR1.60753064
30NEK61.59887816
31CSNK1A1L1.53150701
32BLK1.52877100
33CLK11.48138195
34ADRBK11.45934340
35CSNK1G31.43310918
36LIMK11.42729771
37PRKCQ1.36886001
38IRAK11.35977935
39IRAK41.35478677
40CASK1.33498383
41GRK61.29632240
42CSK1.27422113
43TRPM71.27242102
44NTRK11.25343232
45NTRK31.21375091
46DYRK21.19015124
47TGFBR11.18584645
48NTRK21.18504370
49ROCK21.12613975
50PNCK1.12088905
51ITK1.09366386
52ACVR1B1.09064257
53TXK1.04846447
54MAPK151.02384793
55CSNK1G10.98351225
56MAP2K20.97205179
57UHMK10.96149680
58IKBKE0.95771540
59MAPKAPK30.95740616
60PIK3CA0.95245224
61STK110.94267963
62CSNK1G20.92151204
63PRKCH0.89668924
64TIE10.88652854
65PTK2B0.88040726
66CSF1R0.87745000
67MAP4K20.87221724
68JAK10.85117676
69CAMK2B0.84377452
70MARK10.84150722
71IRAK30.84034037
72STK100.83960100
73LCK0.81689981
74MATK0.80661198
75TYRO30.80487164
76TAF10.79995798
77DYRK30.79904618
78PRKCZ0.79450986
79CAMK1G0.78852841
80MAP3K70.78293282
81PRKCG0.77856500
82IKBKB0.76653167
83ZAP700.74318706
84PAK30.71640259
85GRK10.71396750
86BTK0.69306477
87OBSCN0.68383826
88MAP3K40.68051124
89FYN0.67282050
90MAP2K60.67150649
91MARK30.66584404
92CAMK1D0.65641489
93TBK10.65522057
94PRKD20.64851542
95CAMK2D0.64180908
96PAK60.63744963
97CAMK10.62781157
98RPS6KA50.61674048
99MAP2K40.61580114
100EPHA30.59834353
101MAPKAPK50.58073437
102EPHB20.58071969
103ADRBK20.57824978
104KIT0.57003661
105PHKG10.56779165
106PHKG20.56779165
107ABL10.56564360
108LYN0.55536171
109INSRR0.55447481
110MAP2K70.55417823
111TAOK10.54547050
112HCK0.54524346
113CHUK0.52105057
114CDK50.51801562
115EPHA40.51531665
116MARK20.51448417
117CAMKK20.51366171
118CAMK2G0.51092006
119SGK2230.50505857
120SGK4940.50505857
121PDGFRB0.50444336
122ERBB40.49711381
123RPS6KA60.49284094
124BRD40.48358584
125PRKACA0.47652762
126BMPR1B0.47227016
127PDK10.47141080
128SYK0.45537050
129PRKD10.44941630
130PDPK10.44589591
131CAMK40.44222546
132VRK10.44040605
133PRKG10.43646796
134MAPK120.43313015
135NUAK10.43280206
136CSNK1D0.43018398
137BMPR20.42295333
138JAK30.41761461
139GRK70.40703783
140FES0.40230231
141INSR0.39443086
142BCKDK0.39063660
143MAP3K130.37308869
144CDK140.37284305
145DYRK1B0.37233892
146HIPK20.36735502
147CAMK2A0.36141643
148MAPK70.35710073
149PRKAA20.35626479
150TNK20.34401651
151CSNK1A10.33992304
152MUSK0.33757942
153EIF2AK20.33343802
154RIPK40.33173578
155PRKCE0.33146159
156CDK150.32457035

Predicted pathways (KEGG)

RankGene SetZ-score
1Steroid biosynthesis_Homo sapiens_hsa001003.83616247
2Ether lipid metabolism_Homo sapiens_hsa005652.98922466
3Phototransduction_Homo sapiens_hsa047442.87988099
4Fatty acid elongation_Homo sapiens_hsa000622.76863070
5Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.69274049
6Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.60291090
7Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.37491309
8Nicotine addiction_Homo sapiens_hsa050332.36855165
9Nitrogen metabolism_Homo sapiens_hsa009102.21470557
10Malaria_Homo sapiens_hsa051442.14152593
11Tryptophan metabolism_Homo sapiens_hsa003802.12537912
12Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.05196329
13Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.91478908
14Sphingolipid metabolism_Homo sapiens_hsa006001.90264107
15Autoimmune thyroid disease_Homo sapiens_hsa053201.88707246
16Graft-versus-host disease_Homo sapiens_hsa053321.88568082
17Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.88046515
18Protein export_Homo sapiens_hsa030601.87099347
19Rheumatoid arthritis_Homo sapiens_hsa053231.86391138
20Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.67039532
21Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.64577795
22Primary immunodeficiency_Homo sapiens_hsa053401.64111523
23B cell receptor signaling pathway_Homo sapiens_hsa046621.62402808
24NF-kappa B signaling pathway_Homo sapiens_hsa040641.62193476
25Primary bile acid biosynthesis_Homo sapiens_hsa001201.60660625
26Olfactory transduction_Homo sapiens_hsa047401.59343347
27Linoleic acid metabolism_Homo sapiens_hsa005911.56953694
28Allograft rejection_Homo sapiens_hsa053301.54494731
29Selenocompound metabolism_Homo sapiens_hsa004501.52797016
30alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.50430944
31Parkinsons disease_Homo sapiens_hsa050121.49898033
32Caffeine metabolism_Homo sapiens_hsa002321.43192714
33Taste transduction_Homo sapiens_hsa047421.43002660
34Axon guidance_Homo sapiens_hsa043601.42231536
35Cardiac muscle contraction_Homo sapiens_hsa042601.42011202
36Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.39929106
37Hematopoietic cell lineage_Homo sapiens_hsa046401.39210393
38Sulfur metabolism_Homo sapiens_hsa009201.33862538
39Phagosome_Homo sapiens_hsa041451.32489070
40Vitamin B6 metabolism_Homo sapiens_hsa007501.32153058
41Lysosome_Homo sapiens_hsa041421.31974921
42Histidine metabolism_Homo sapiens_hsa003401.30703468
43Glycosaminoglycan degradation_Homo sapiens_hsa005311.28110015
44Ribosome_Homo sapiens_hsa030101.23240312
45Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.22886433
46Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.22831524
47Maturity onset diabetes of the young_Homo sapiens_hsa049501.21599790
48Butanoate metabolism_Homo sapiens_hsa006501.21287693
49Chemokine signaling pathway_Homo sapiens_hsa040621.20798907
50T cell receptor signaling pathway_Homo sapiens_hsa046601.20672156
51Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.20212760
52Collecting duct acid secretion_Homo sapiens_hsa049661.20149582
53NOD-like receptor signaling pathway_Homo sapiens_hsa046211.15910292
54Salmonella infection_Homo sapiens_hsa051321.15775702
55Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.14124731
56SNARE interactions in vesicular transport_Homo sapiens_hsa041301.13943551
57Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.12366282
58Calcium signaling pathway_Homo sapiens_hsa040201.08221989
59Leishmaniasis_Homo sapiens_hsa051401.07167160
60Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.06474067
61Leukocyte transendothelial migration_Homo sapiens_hsa046701.03462455
62Cyanoamino acid metabolism_Homo sapiens_hsa004600.98894749
63Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.98705228
64Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.95793815
65Asthma_Homo sapiens_hsa053100.94137773
66Staphylococcus aureus infection_Homo sapiens_hsa051500.93438834
67Intestinal immune network for IgA production_Homo sapiens_hsa046720.92865169
68Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.92861357
69Oxidative phosphorylation_Homo sapiens_hsa001900.92809858
70Renal cell carcinoma_Homo sapiens_hsa052110.92334632
71Arachidonic acid metabolism_Homo sapiens_hsa005900.91145867
72Measles_Homo sapiens_hsa051620.90858629
73Pertussis_Homo sapiens_hsa051330.87309410
74Sphingolipid signaling pathway_Homo sapiens_hsa040710.87122378
75Fat digestion and absorption_Homo sapiens_hsa049750.86601274
76Glycerolipid metabolism_Homo sapiens_hsa005610.85881966
77ABC transporters_Homo sapiens_hsa020100.85212692
78Tuberculosis_Homo sapiens_hsa051520.84585790
79Huntingtons disease_Homo sapiens_hsa050160.83553650
80Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.80582571
81Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.80425249
82Osteoclast differentiation_Homo sapiens_hsa043800.80185489
83Peroxisome_Homo sapiens_hsa041460.78994160
84Sulfur relay system_Homo sapiens_hsa041220.78314489
85Cocaine addiction_Homo sapiens_hsa050300.78168819
86Endocytosis_Homo sapiens_hsa041440.78158074
87Ovarian steroidogenesis_Homo sapiens_hsa049130.77984990
88Morphine addiction_Homo sapiens_hsa050320.77858763
89Cholinergic synapse_Homo sapiens_hsa047250.77632514
90Vibrio cholerae infection_Homo sapiens_hsa051100.77474573
91Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.76808039
92Dorso-ventral axis formation_Homo sapiens_hsa043200.76413245
93Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.74283519
94Chemical carcinogenesis_Homo sapiens_hsa052040.74256004
95Serotonergic synapse_Homo sapiens_hsa047260.73042368
96Shigellosis_Homo sapiens_hsa051310.72305803
97* Regulation of actin cytoskeleton_Homo sapiens_hsa048100.71999604
98Circadian entrainment_Homo sapiens_hsa047130.71865108
99Salivary secretion_Homo sapiens_hsa049700.71475239
100Fanconi anemia pathway_Homo sapiens_hsa034600.70920445
101Vascular smooth muscle contraction_Homo sapiens_hsa042700.70777582
102Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.68453889
103Regulation of autophagy_Homo sapiens_hsa041400.68199874
104Tight junction_Homo sapiens_hsa045300.67336823
105Insulin secretion_Homo sapiens_hsa049110.66994293
106Gastric acid secretion_Homo sapiens_hsa049710.66298897
107Other glycan degradation_Homo sapiens_hsa005110.64368945
108Oxytocin signaling pathway_Homo sapiens_hsa049210.63370563
109Basal transcription factors_Homo sapiens_hsa030220.62566470
110Ras signaling pathway_Homo sapiens_hsa040140.61301267
111Type I diabetes mellitus_Homo sapiens_hsa049400.61272710
112Alzheimers disease_Homo sapiens_hsa050100.61106102
113Phospholipase D signaling pathway_Homo sapiens_hsa040720.60860320
114Hepatitis C_Homo sapiens_hsa051600.59322132
115African trypanosomiasis_Homo sapiens_hsa051430.56740012
116Platelet activation_Homo sapiens_hsa046110.56570909
117Glutamatergic synapse_Homo sapiens_hsa047240.55304296
118Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.54828317
119Antigen processing and presentation_Homo sapiens_hsa046120.54530055
120Glutathione metabolism_Homo sapiens_hsa004800.53623150
121Toll-like receptor signaling pathway_Homo sapiens_hsa046200.52744881
122Arginine and proline metabolism_Homo sapiens_hsa003300.52552514
123Mineral absorption_Homo sapiens_hsa049780.51525158
124RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.50097623
125Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.49456143
126Retinol metabolism_Homo sapiens_hsa008300.49325903
127Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.48615200
128Jak-STAT signaling pathway_Homo sapiens_hsa046300.48563048
129Circadian rhythm_Homo sapiens_hsa047100.48092899
130Steroid hormone biosynthesis_Homo sapiens_hsa001400.48089293
131ECM-receptor interaction_Homo sapiens_hsa045120.46067420
132Carbohydrate digestion and absorption_Homo sapiens_hsa049730.43547189
133Fatty acid biosynthesis_Homo sapiens_hsa000610.43372861
134GABAergic synapse_Homo sapiens_hsa047270.42937410
135Pancreatic secretion_Homo sapiens_hsa049720.39541189
136Glycerophospholipid metabolism_Homo sapiens_hsa005640.38475945
137Adipocytokine signaling pathway_Homo sapiens_hsa049200.37119029
138Homologous recombination_Homo sapiens_hsa034400.36741035
139cAMP signaling pathway_Homo sapiens_hsa040240.35929970
140Phosphatidylinositol signaling system_Homo sapiens_hsa040700.34519128
141MAPK signaling pathway_Homo sapiens_hsa040100.34248656
142Long-term depression_Homo sapiens_hsa047300.33275579
143Prostate cancer_Homo sapiens_hsa052150.32666359
144ErbB signaling pathway_Homo sapiens_hsa040120.32624062
145Inositol phosphate metabolism_Homo sapiens_hsa005620.30868523
146Toxoplasmosis_Homo sapiens_hsa051450.30355199
147TNF signaling pathway_Homo sapiens_hsa046680.28465076

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