ITGAX

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes the integrin alpha X chain protein. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This protein combines with the beta 2 chain (ITGB2) to form a leukocyte-specific integrin referred to as inactivated-C3b (iC3b) receptor 4 (CR4). The alpha X beta 2 complex seems to overlap the properties of the alpha M beta 2 integrin in the adherence of neutrophils and monocytes to stimulated endothelium cells, and in the phagocytosis of complement coated particles. Two transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G6.59207493
2modulation by symbiont of host defense response (GO:0052031)5.88941218
3modulation by organism of immune response of other organism involved in symbiotic interaction (GO:005.88941218
4modulation by organism of defense response of other organism involved in symbiotic interaction (GO:05.88941218
5positive regulation by organism of defense response of other organism involved in symbiotic interact5.88941218
6modulation by symbiont of host immune response (GO:0052553)5.88941218
7positive regulation by symbiont of host defense response (GO:0052509)5.88941218
8neutrophil activation involved in immune response (GO:0002283)5.72802294
9detection of other organism (GO:0098543)4.74735369
10immunoglobulin mediated immune response (GO:0016064)4.62376959
11respiratory burst (GO:0045730)4.51171741
12response to peptidoglycan (GO:0032494)4.50228902
13granulocyte activation (GO:0036230)4.49758308
14detection of bacterium (GO:0016045)4.45357096
15regulation of interferon-beta biosynthetic process (GO:0045357)4.43657084
16production of molecular mediator involved in inflammatory response (GO:0002532)4.42764763
17macrophage activation involved in immune response (GO:0002281)4.42409561
18positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)4.35336831
19positive regulation of interferon-alpha production (GO:0032727)4.34581928
20neutrophil activation (GO:0042119)4.34441800
21detection of external biotic stimulus (GO:0098581)4.27432131
22positive regulation of interleukin-8 biosynthetic process (GO:0045416)4.13603787
23regulation of interferon-alpha production (GO:0032647)4.07733953
24regulation of gamma-delta T cell activation (GO:0046643)4.06780498
25hydrogen peroxide biosynthetic process (GO:0050665)3.98506037
26positive regulation of gamma-delta T cell activation (GO:0046645)3.93680305
27positive regulation of cellular amide metabolic process (GO:0034250)3.91664408
28negative regulation of lymphocyte mediated immunity (GO:0002707)3.87356134
29cellular extravasation (GO:0045123)3.86348272
30leukocyte migration involved in inflammatory response (GO:0002523)3.83571850
31detection of biotic stimulus (GO:0009595)3.79316379
32response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.78805588
33response to host immune response (GO:0052572)3.78805588
34lipopolysaccharide-mediated signaling pathway (GO:0031663)3.78713062
35positive regulation of myeloid leukocyte cytokine production involved in immune response (GO:00610813.74834942
36positive regulation of mast cell activation (GO:0033005)3.72731770
37positive regulation of macrophage cytokine production (GO:0060907)3.72555790
38positive regulation of antigen processing and presentation (GO:0002579)3.71101930
39positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.70752309
40antigen processing and presentation of endogenous antigen (GO:0019883)3.69498187
41superoxide anion generation (GO:0042554)3.66982210
42myeloid cell activation involved in immune response (GO:0002275)3.65112692
43germinal center formation (GO:0002467)3.59829691
44regulation of syncytium formation by plasma membrane fusion (GO:0060142)3.57934555
45regulation of B cell receptor signaling pathway (GO:0050855)3.54423556
46cellular response to zinc ion (GO:0071294)3.52704379
47negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.50811485
48negative regulation of cell killing (GO:0031342)3.50811485
49negative regulation of leukocyte mediated immunity (GO:0002704)3.50024038
50regulation of mononuclear cell migration (GO:0071675)3.50015782
51reactive oxygen species biosynthetic process (GO:1903409)3.49545239
52regulation of myeloid leukocyte mediated immunity (GO:0002886)3.49313688
53microglial cell activation (GO:0001774)3.49182783
54response to muramyl dipeptide (GO:0032495)3.47387792
55eosinophil chemotaxis (GO:0048245)3.46077977
56negative regulation of interleukin-17 production (GO:0032700)3.46023816
57positive regulation of chemokine biosynthetic process (GO:0045080)3.45256947
58positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.44068508
59negative regulation of T cell mediated immunity (GO:0002710)3.41336982
60positive regulation of mast cell degranulation (GO:0043306)3.40113985
61positive regulation of mast cell activation involved in immune response (GO:0033008)3.40113985
62B cell mediated immunity (GO:0019724)3.39786648
63response to interleukin-15 (GO:0070672)3.38473695
64myeloid dendritic cell differentiation (GO:0043011)3.35855874
65response to host (GO:0075136)3.35401801
66response to host defenses (GO:0052200)3.35401801
67response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.35401801
68regulation of cholesterol storage (GO:0010885)3.34691745
69regulation of gamma-delta T cell differentiation (GO:0045586)3.34669838
70type I interferon signaling pathway (GO:0060337)3.31102952
71cellular response to type I interferon (GO:0071357)3.31102952
72negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.31066794
73natural killer cell mediated cytotoxicity (GO:0042267)3.30621814
74natural killer cell mediated immunity (GO:0002228)3.30621814
75regulation of T-helper 1 cell differentiation (GO:0045625)3.30424152
76myeloid dendritic cell activation (GO:0001773)3.29623862
77response to type I interferon (GO:0034340)3.28794340
78regulation of T-helper 2 cell differentiation (GO:0045628)3.27650900
79regulation of mast cell degranulation (GO:0043304)3.26442634
80positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.26370958
81positive regulation of monocyte chemotaxis (GO:0090026)3.22035006
82wound healing, spreading of epidermal cells (GO:0035313)3.21921596
83regulation of dendritic cell antigen processing and presentation (GO:0002604)3.21338544
84macrophage activation (GO:0042116)3.19615576
85regulation of mast cell activation (GO:0033003)3.16357594
86regulation of tumor necrosis factor biosynthetic process (GO:0042534)3.15985095
87positive regulation of interferon-beta production (GO:0032728)3.14823844
88regulation of T cell tolerance induction (GO:0002664)3.14014588
89eosinophil migration (GO:0072677)3.12953100
90regulation of B cell differentiation (GO:0045577)3.12234817
91response to protozoan (GO:0001562)3.11708058
92leukocyte aggregation (GO:0070486)3.11399019
93regulation of tolerance induction (GO:0002643)3.10445755
94regulation of antigen processing and presentation (GO:0002577)3.08388416
95regulation of interleukin-12 biosynthetic process (GO:0045075)3.08297041
96monocyte chemotaxis (GO:0002548)3.07792761
97negative regulation of cytokine production involved in immune response (GO:0002719)3.07334951
98regulation of macrophage cytokine production (GO:0010935)3.07069064
99phagocytosis, recognition (GO:0006910)3.05987570
100cellular response to interleukin-15 (GO:0071350)3.04915028
101leukocyte mediated cytotoxicity (GO:0001909)3.02981360
102T cell migration (GO:0072678)3.01768882
103leukocyte degranulation (GO:0043299)3.01123506
104neutrophil chemotaxis (GO:0030593)3.01116496
105myeloid leukocyte mediated immunity (GO:0002444)3.00592101
106regulation of mast cell activation involved in immune response (GO:0033006)3.00376369
107interferon-gamma-mediated signaling pathway (GO:0060333)3.00024731
108myeloid leukocyte activation (GO:0002274)2.99357861
109B cell receptor signaling pathway (GO:0050853)2.98873052
110positive regulation of B cell differentiation (GO:0045579)2.98180357
111defense response to protozoan (GO:0042832)2.97053286
112low-density lipoprotein particle clearance (GO:0034383)2.96948853
113negative regulation of erythrocyte differentiation (GO:0045647)2.96627502
114positive regulation of myeloid leukocyte mediated immunity (GO:0002888)2.96065595
115neutrophil mediated immunity (GO:0002446)2.95206122
116positive regulation of interleukin-12 production (GO:0032735)2.95184063
117leukocyte cell-cell adhesion (GO:0007159)2.94003448
118antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.93290633
119antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.93290633
120neutrophil migration (GO:1990266)2.92712448
121antigen processing and presentation via MHC class Ib (GO:0002475)2.92122115
122phagosome maturation (GO:0090382)2.92071577
123negative regulation of T-helper cell differentiation (GO:0045623)2.91118327
124negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.91118327
125regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.90258237
126positive regulation of tumor necrosis factor superfamily cytokine production (GO:1903557)2.89968036
127regulation of nitric-oxide synthase biosynthetic process (GO:0051769)2.89607743
128negative regulation of interleukin-6 production (GO:0032715)2.89364495
129positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.88949923
130regulation of regulated secretory pathway (GO:1903305)2.88935936
131positive regulation of leukocyte degranulation (GO:0043302)2.88734794
132negative regulation of innate immune response (GO:0045824)2.87406513
133negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.85158738
134negative regulation of interleukin-12 production (GO:0032695)2.84893483
135regulation of chemokine biosynthetic process (GO:0045073)2.84524191
136Arp2/3 complex-mediated actin nucleation (GO:0034314)2.82546774
137regulation of leukocyte degranulation (GO:0043300)2.82451193
138detection of molecule of bacterial origin (GO:0032490)2.82013034
139T-helper 1 type immune response (GO:0042088)2.80147567

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human7.78612674
2IRF8_21731497_ChIP-ChIP_J774_Mouse6.76989131
3IRF8_22096565_ChIP-ChIP_GC-B_Human6.55546946
4IRF8_27001747_Chip-Seq_BMDM_Mouse4.49994312
5SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse4.14880585
6Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse3.99909062
7NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse3.69100275
8FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.61616263
9IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.54195356
10MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.37774230
11STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.37171661
12MYB_21317192_ChIP-Seq_ERMYB_Mouse3.08275707
13IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.01322420
14STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.89410395
15RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.85458127
16EGR1_19374776_ChIP-ChIP_THP-1_Human2.77648880
17SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.63423942
18STAT4_19710469_ChIP-ChIP_TH1__Mouse2.42087255
19NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.29974341
20NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.23617356
21BRD4_27068464_Chip-Seq_AML-cells_Mouse2.22130112
22PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse2.12843539
23* SPI1_23547873_ChIP-Seq_NB4_Human2.12561671
24RUNX_20019798_ChIP-Seq_JUKART_Human2.00858449
25STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.93731998
26VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.89842856
27VDR_24787735_ChIP-Seq_THP-1_Human1.86157699
28MYB_26560356_Chip-Seq_TH2_Human1.81131182
29RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.80451312
30CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.77593792
31MYC_22102868_ChIP-Seq_BL_Human1.77449023
32VDR_24763502_ChIP-Seq_THP-1_Human1.77370706
33SPI1_23127762_ChIP-Seq_K562_Human1.75756527
34CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.75222272
35PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.67665026
36PU_27001747_Chip-Seq_BMDM_Mouse1.66243187
37* RUNX1_22412390_ChIP-Seq_EML_Mouse1.65338447
38FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.61748866
39MAF_26560356_Chip-Seq_TH1_Human1.56856476
40STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.55105780
41STAT6_21828071_ChIP-Seq_BEAS2B_Human1.53189011
42CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.48712285
43THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.47027912
44CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.45398601
45ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.42838381
46CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.37978217
47MYB_26560356_Chip-Seq_TH1_Human1.33276606
48SCL_19346495_ChIP-Seq_HPC-7_Human1.32491433
49NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.30223781
50VDR_21846776_ChIP-Seq_THP-1_Human1.29329069
51* MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.29302153
52PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.28426766
53E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.27718862
54* GATA3_27048872_Chip-Seq_THYMUS_Human1.26879826
55LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.21217941
56LXR_22292898_ChIP-Seq_THP-1_Human1.19231398
57SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.17905812
58FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.14219973
59* GATA3_26560356_Chip-Seq_TH2_Human1.13560106
60SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.13322421
61GATA2_21666600_ChIP-Seq_HMVEC_Human1.12282340
62GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.12073108
63PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.11832678
64VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.11773287
65GATA1_22025678_ChIP-Seq_K562_Human1.11622766
66CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.06089359
67TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.04253343
68IKZF1_21737484_ChIP-ChIP_HCT116_Human1.03295393
69TCF7_22412390_ChIP-Seq_EML_Mouse1.02720208
70KDM2B_26808549_Chip-Seq_JURKAT_Human1.02599062
71UTX_26944678_Chip-Seq_JUKART_Human1.02510033
72PU.1_20513432_ChIP-Seq_Bcells_Mouse1.00802451
73GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.99908985
74BCL6_27268052_Chip-Seq_Bcells_Human0.98807445
75LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.98565545
76SMAD_19615063_ChIP-ChIP_OVARY_Human0.98314926
77GATA2_22383799_ChIP-Seq_G1ME_Mouse0.97880747
78NRF2_20460467_ChIP-Seq_MEFs_Mouse0.96640397
79NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.96640397
80ELK3_25401928_ChIP-Seq_HUVEC_Human0.94213549
81* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.93056081
82TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.90874919
83SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.90764970
84BCOR_27268052_Chip-Seq_Bcells_Human0.89704566
85KDM2B_26808549_Chip-Seq_SUP-B15_Human0.89569897
86CDX2_19796622_ChIP-Seq_MESCs_Mouse0.85112060
87SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.82785710
88MAF_26560356_Chip-Seq_TH2_Human0.81344273
89RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.80737593
90NCOR1_26117541_ChIP-Seq_K562_Human0.78999099
91GATA1_19941827_ChIP-Seq_MEL86_Mouse0.77239575
92JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.76413880
93CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.75630076
94GATA1_19941827_ChIP-Seq_MEL_Mouse0.75474778
95TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.75276331
96SOX2_20726797_ChIP-Seq_SW620_Human0.74827182
97CTCF_27219007_Chip-Seq_ERYTHROID_Human0.74790001
98KDM2B_26808549_Chip-Seq_DND41_Human0.74610296
99GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.73814325
100JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.73614005
101SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.73349951
102SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.73349951
103GATA2_19941826_ChIP-Seq_K562_Human0.73155620
104KDM2B_26808549_Chip-Seq_K562_Human0.72648453
105CJUN_26792858_Chip-Seq_BT549_Human0.72252513
106FOXO3_23340844_ChIP-Seq_DLD1_Human0.71880547
107GATA1_22383799_ChIP-Seq_G1ME_Mouse0.69732613
108EGR1_19032775_ChIP-ChIP_M12_Human0.69260510
109ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.69178655
110KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.68130079
111RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.67975744
112TFEB_21752829_ChIP-Seq_HELA_Human0.67722705
113CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.67157719
114KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.66910112
115* SMRT_27268052_Chip-Seq_Bcells_Human0.65792408
116* BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.64539547
117SPI1_20517297_ChIP-Seq_HL60_Human0.64056397
118GATA1_19941826_ChIP-Seq_K562_Human0.64018741

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation4.80198696
2MP0003436_decreased_susceptibility_to3.89046430
3MP0003303_peritoneal_inflammation3.77470778
4MP0006082_CNS_inflammation3.56744133
5MP0002148_abnormal_hypersensitivity_rea3.47046255
6MP0002419_abnormal_innate_immunity3.41323297
7MP0009785_altered_susceptibility_to3.24473742
8* MP0005000_abnormal_immune_tolerance3.20830194
9MP0005058_abnormal_lysosome_morphology2.94165400
10* MP0005025_abnormal_response_to2.89692066
11MP0005671_abnormal_response_to2.87990641
12MP0002452_abnormal_antigen_presenting2.79561433
13MP0004510_myositis2.76656873
14MP0001790_abnormal_immune_system2.69552931
15MP0005387_immune_system_phenotype2.69552931
16MP0003724_increased_susceptibility_to2.68047469
17MP0000685_abnormal_immune_system2.56147301
18* MP0002723_abnormal_immune_serum2.48367086
19MP0001800_abnormal_humoral_immune2.46310465
20* MP0001819_abnormal_immune_cell2.34752321
21* MP0002420_abnormal_adaptive_immunity2.32012097
22MP0005464_abnormal_platelet_physiology2.17376249
23MP0002405_respiratory_system_inflammati2.16739475
24MP0003448_altered_tumor_morphology2.02616913
25MP0003191_abnormal_cellular_cholesterol2.01287914
26MP0001853_heart_inflammation2.00809945
27MP0003172_abnormal_lysosome_physiology1.99496474
28MP0001533_abnormal_skeleton_physiology1.92687243
29MP0004947_skin_inflammation1.90506502
30MP0001845_abnormal_inflammatory_respons1.88263550
31MP0005451_abnormal_body_composition1.79041155
32MP0003075_altered_response_to1.72056601
33MP0002998_abnormal_bone_remodeling1.69992247
34MP0005310_abnormal_salivary_gland1.68391055
35MP0009764_decreased_sensitivity_to1.65630124
36MP0003690_abnormal_glial_cell1.63376129
37* MP0000716_abnormal_immune_system1.61913104
38MP0008469_abnormal_protein_level1.59986418
39MP0000343_altered_response_to1.57915486
40MP0002006_tumorigenesis1.56598984
41MP0000569_abnormal_digit_pigmentation1.56007340
42MP0000858_altered_metastatic_potential1.55947034
43MP0009840_abnormal_foam_cell1.52919352
44MP0005166_decreased_susceptibility_to1.52287855
45MP0010155_abnormal_intestine_physiology1.51336391
46MP0009333_abnormal_splenocyte_physiolog1.44313936
47* MP0002398_abnormal_bone_marrow1.44003155
48MP0001851_eye_inflammation1.41279909
49MP0005257_abnormal_intraocular_pressure1.34583457
50MP0000604_amyloidosis1.29037723
51MP0003300_gastrointestinal_ulcer1.27565954
52* MP0002429_abnormal_blood_cell1.27420228
53MP0010386_abnormal_urinary_bladder1.26781131
54MP0000689_abnormal_spleen_morphology1.26110915
55MP0002277_abnormal_respiratory_mucosa1.25206395
56MP0005167_abnormal_blood-brain_barrier1.25051605
57MP0009278_abnormal_bone_marrow1.21744919
58MP0008004_abnormal_stomach_pH1.21237639
59MP0002722_abnormal_immune_system1.18673029
60MP0003828_pulmonary_edema1.16360415
61MP0004782_abnormal_surfactant_physiolog1.15601264
62MP0001545_abnormal_hematopoietic_system1.13853090
63MP0005397_hematopoietic_system_phenotyp1.13853090
64MP0003566_abnormal_cell_adhesion1.10077897
65MP0005174_abnormal_tail_pigmentation1.08377226
66MP0002396_abnormal_hematopoietic_system1.06856240
67MP0002933_joint_inflammation1.06618082
68MP0000703_abnormal_thymus_morphology1.06337844
69MP0004381_abnormal_hair_follicle1.03956947
70MP0002166_altered_tumor_susceptibility1.02161255
71MP0010307_abnormal_tumor_latency1.00934817
72MP0002254_reproductive_system_inflammat0.99647056
73MP0010352_gastrointestinal_tract_polyps0.94949150
74MP0005390_skeleton_phenotype0.92914219
75MP0003705_abnormal_hypodermis_morpholog0.91687031
76MP0003806_abnormal_nucleotide_metabolis0.91454633
77MP0004130_abnormal_muscle_cell0.91355642
78MP0005076_abnormal_cell_differentiation0.90797674
79MP0009763_increased_sensitivity_to0.90620135
80MP0005164_abnormal_response_to0.90581570
81MP0000371_diluted_coat_color0.88327628
82MP0003183_abnormal_peptide_metabolism0.88035133
83MP0003186_abnormal_redox_activity0.86319880
84MP0002138_abnormal_hepatobiliary_system0.85386155
85MP0003453_abnormal_keratinocyte_physiol0.80282824
86MP0000920_abnormal_myelination0.79723606
87MP0002332_abnormal_exercise_endurance0.78760111
88MP0000465_gastrointestinal_hemorrhage0.78255749
89MP0002090_abnormal_vision0.76984958
90MP0003795_abnormal_bone_structure0.75972765
91MP0008260_abnormal_autophagy0.75382863
92MP0000249_abnormal_blood_vessel0.74414348
93MP0009765_abnormal_xenobiotic_induced0.74347129
94MP0001958_emphysema0.72905828
95MP0001986_abnormal_taste_sensitivity0.71221527
96MP0002136_abnormal_kidney_physiology0.68812734
97MP0001873_stomach_inflammation0.68268062
98MP0003866_abnormal_defecation0.68250736
99MP0003763_abnormal_thymus_physiology0.67639652
100MP0003045_fibrosis0.66926932
101MP0008874_decreased_physiological_sensi0.65593398
102MP0003091_abnormal_cell_migration0.64288737
103MP0001663_abnormal_digestive_system0.63426358
104MP0003279_aneurysm0.63205331
105MP0004883_abnormal_blood_vessel0.62479233
106MP0003329_amyloid_beta_deposits0.61085911
107MP0000767_abnormal_smooth_muscle0.58174061
108MP0006054_spinal_hemorrhage0.55912657
109MP0000490_abnormal_crypts_of0.55744925
110MP0003656_abnormal_erythrocyte_physiolo0.55219214
111MP0005319_abnormal_enzyme/_coenzyme0.54837088
112MP0004808_abnormal_hematopoietic_stem0.53206211
113MP0000015_abnormal_ear_pigmentation0.52146102
114MP0004185_abnormal_adipocyte_glucose0.51931349
115MP0002132_abnormal_respiratory_system0.51234807
116MP0003221_abnormal_cardiomyocyte_apopto0.50395306
117MP0002877_abnormal_melanocyte_morpholog0.50088411
118MP0005075_abnormal_melanosome_morpholog0.49339944

Predicted human phenotypes

RankGene SetZ-score
1Recurrent abscess formation (HP:0002722)7.56020403
2Recurrent gram-negative bacterial infections (HP:0005420)7.20898453
3Eczematoid dermatitis (HP:0000976)7.20841937
4Recurrent bacterial skin infections (HP:0005406)6.63544925
5Abnormality of macrophages (HP:0004311)5.52488781
6Increased cerebral lipofuscin (HP:0011813)5.24492974
7Vacuolated lymphocytes (HP:0001922)5.21355600
8Mediastinal lymphadenopathy (HP:0100721)4.77133591
9Abnormality of liposaccharide metabolism (HP:0010968)4.37182525
10Abnormality of glycosphingolipid metabolism (HP:0004343)4.37182525
11Abnormality of glycolipid metabolism (HP:0010969)4.37182525
12Gingivitis (HP:0000230)4.35200047
13Recurrent skin infections (HP:0001581)4.30798956
14Recurrent fungal infections (HP:0002841)4.10767007
15Increased neuronal autofluorescent lipopigment (HP:0002074)4.04052316
16Obstructive lung disease (HP:0006536)4.03193141
17Chronic obstructive pulmonary disease (HP:0006510)4.03193141
18Myositis (HP:0100614)3.80395936
19Orchitis (HP:0100796)3.67208691
20Retrobulbar optic neuritis (HP:0100654)3.58867226
21Optic neuritis (HP:0100653)3.58867226
22Axonal loss (HP:0003447)3.53644324
23Dysostosis multiplex (HP:0000943)3.50840955
24Elevated erythrocyte sedimentation rate (HP:0003565)3.47790950
25Abnormal delayed hypersensitivity skin test (HP:0002963)3.47247400
26Encephalitis (HP:0002383)3.46343480
27Autoimmune thrombocytopenia (HP:0001973)3.46216182
28Recurrent cutaneous fungal infections (HP:0011370)3.38637694
29Chronic mucocutaneous candidiasis (HP:0002728)3.38637694
30Stomatitis (HP:0010280)3.34230682
31Systemic lupus erythematosus (HP:0002725)3.29406940
32Interstitial pulmonary disease (HP:0006530)3.25038727
33Recurrent viral infections (HP:0004429)3.20725020
34Myocardial infarction (HP:0001658)3.19719981
35Periodontitis (HP:0000704)3.16721884
36Increased IgE level (HP:0003212)3.15387066
37Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)3.08977633
38Vasculitis (HP:0002633)3.08686982
39Disinhibition (HP:0000734)3.07728173
40Loss of speech (HP:0002371)3.03186927
41Cellulitis (HP:0100658)3.02738075
42Chest pain (HP:0100749)2.93629079
43Mucopolysacchariduria (HP:0008155)2.92307040
44Urinary glycosaminoglycan excretion (HP:0003541)2.92307040
45Amyloidosis (HP:0011034)2.90841803
46Basal ganglia calcification (HP:0002135)2.88319501
47Episodic fever (HP:0001954)2.78565936
48Meningitis (HP:0001287)2.73116939
49Urticaria (HP:0001025)2.72531555
50Abnormality of polysaccharide metabolism (HP:0011012)2.72082744
51Abnormality of glycosaminoglycan metabolism (HP:0004371)2.72082744
52Abnormality of mucopolysaccharide metabolism (HP:0011020)2.72082744
53Joint hemorrhage (HP:0005261)2.63300452
54Anorexia (HP:0002039)2.62707068
55Agnosia (HP:0010524)2.61970193
56Pulmonary embolism (HP:0002204)2.58964107
57Pulmonary infiltrates (HP:0002113)2.51238881
58Arterial thrombosis (HP:0004420)2.50739287
59Leukocytosis (HP:0001974)2.50325907
60Hematochezia (HP:0002573)2.50162998
61Hepatosplenomegaly (HP:0001433)2.49494071
62Hemoptysis (HP:0002105)2.49029637
63Pustule (HP:0200039)2.48663360
64Osteomyelitis (HP:0002754)2.45291416
65Spontaneous hematomas (HP:0007420)2.45229141
66Gangrene (HP:0100758)2.45219524
67Peritonitis (HP:0002586)2.43371337
68Gastrointestinal inflammation (HP:0004386)2.41928206
69Abnormality of T cell number (HP:0011839)2.37307321
70Thick nail (HP:0001805)2.34879343
71Abnormality of the pleura (HP:0002103)2.32807343
72Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.32627248
73Increased IgM level (HP:0003496)2.32020898
74Gingival bleeding (HP:0000225)2.30804234
75T lymphocytopenia (HP:0005403)2.29645710
76Glomerulonephritis (HP:0000099)2.29240524
77Abnormality of T cells (HP:0002843)2.28361368
78Increased serum ferritin (HP:0003281)2.27775943
79Recurrent pneumonia (HP:0006532)2.26598500
80Abnormality of the vasculature of the conjunctiva (HP:0008054)2.26162431
81Panhypogammaglobulinemia (HP:0003139)2.25982243
82Granulocytopenia (HP:0001913)2.20751050
83Hypochromic anemia (HP:0001931)2.19275047
84Abnormality of the endocardium (HP:0004306)2.15887506
85Osteolytic defects of the hand bones (HP:0009699)2.14512973
86Osteolytic defects of the phalanges of the hand (HP:0009771)2.14512973
87Premature loss of primary teeth (HP:0006323)2.12897320
88Hypochromic microcytic anemia (HP:0004840)2.11759767
89Hypergammaglobulinemia (HP:0010702)2.09836224
90Vertigo (HP:0002321)2.09456995
91Keratoconjunctivitis sicca (HP:0001097)2.09114095
92Abnormality of the peritoneum (HP:0002585)2.08985955
93Prostate neoplasm (HP:0100787)2.08464622
94Polyneuropathy (HP:0001271)2.07947052
95Chronic otitis media (HP:0000389)2.06329769
96Colitis (HP:0002583)2.05285981
97Glomerulopathy (HP:0100820)2.05168211
98Gastrointestinal infarctions (HP:0005244)2.05073748
99Abnormality of iron homeostasis (HP:0011031)2.01554822
100Recurrent lower respiratory tract infections (HP:0002783)2.00768768
101Epistaxis (HP:0000421)2.00623697
102Abnormality of the lumbar spine (HP:0100712)2.00600853
103Cheilitis (HP:0100825)1.99672593
104Lymphopenia (HP:0001888)1.98700985
105Acne (HP:0001061)1.98567279
106Petechiae (HP:0000967)1.98205524
107Peripheral demyelination (HP:0011096)1.97985659
108Sepsis (HP:0100806)1.97790913
109Prolonged bleeding time (HP:0003010)1.96203044
110Poor head control (HP:0002421)1.96184783
111Esophageal varix (HP:0002040)1.96063529
112Slow saccadic eye movements (HP:0000514)1.95314489
113Mutism (HP:0002300)1.94795275
114Bone pain (HP:0002653)1.93964494
115Inflammation of the large intestine (HP:0002037)1.93419981
116Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.92385769
117J-shaped sella turcica (HP:0002680)1.92358999
118Keratitis (HP:0000491)1.91387649
119Eosinophilia (HP:0001880)1.91257835
120Nausea (HP:0002018)1.89938934
121IgM deficiency (HP:0002850)1.89860543
122Segmental peripheral demyelination/remyelination (HP:0003481)1.89446536
123Restrictive lung disease (HP:0002091)1.88832280
124Keratoconjunctivitis (HP:0001096)1.88139275
125Pathologic fracture (HP:0002756)1.87790283
126Upper motor neuron abnormality (HP:0002127)1.87167162
127Nephritis (HP:0000123)1.86426558
128Increased CSF protein (HP:0002922)1.85278238
129Abnormality of the nasal mucosa (HP:0000433)1.84627148
130Menorrhagia (HP:0000132)1.84476490
131Purpura (HP:0000979)1.83778743
132Nasal polyposis (HP:0100582)1.82793639
133Gastrointestinal stroma tumor (HP:0100723)1.81544157
134Tetraparesis (HP:0002273)1.80477979

Predicted kinase interactions (KEA)

RankGene SetZ-score
1RIPK46.00250629
2BLK4.10443768
3MAP4K13.79150230
4MAP3K143.78394276
5PBK3.48842283
6TBK12.88916290
7IRAK42.63127538
8TYK22.58189574
9IRAK32.37921449
10JAK32.36442360
11IKBKB2.10684370
12PRPF4B2.06993190
13TNK22.00783556
14TAOK11.90511263
15KIT1.86124550
16MAP3K31.85380803
17MAP3K131.81068570
18JAK11.79293072
19TXK1.77807702
20ERN11.75953850
21CSK1.72042183
22IKBKE1.59983966
23NME21.49887611
24ZAP701.49660809
25NEK91.48333416
26TGFBR21.44082478
27BMX1.39416843
28MARK31.38882071
29FGR1.38624099
30ABL21.38230993
31SYK1.37858224
32STK101.36787559
33JAK21.29869443
34HCK1.29489406
35MST41.28182740
36CSF1R1.25412341
37TAOK21.16126821
38BTK1.14427974
39CHUK1.13994502
40LCK1.10930582
41LYN1.09613278
42PIM21.09507662
43EPHB11.08865474
44TTN1.04873316
45FES1.04721013
46CDC42BPA1.03068131
47TRIB31.03043383
48BMPR21.01067233
49MST1R1.00169364
50LRRK20.98900045
51PIM10.96916438
52GRK70.95906008
53MARK20.95706119
54TRPM70.95506417
55RPS6KA40.89912801
56TAOK30.89575844
57YES10.89547992
58ITK0.85634047
59RIPK10.85333410
60TEC0.82561732
61STK40.82196546
62MATK0.80402885
63PRKD20.79760424
64SIK30.78506613
65FGFR30.77886018
66PRKCQ0.75280071
67PRKCH0.74004571
68ABL10.71854857
69MAP3K60.71278958
70MAP3K110.69284818
71PRKCD0.69101842
72CLK10.68664136
73ERBB30.66007786
74MAP3K120.64757054
75SIK20.63514124
76MAPK120.63417572
77TESK20.62866719
78EGFR0.61984110
79PDGFRB0.61920726
80MAPK70.61580874
81MAP3K100.56717496
82PDK10.56615751
83MOS0.56181922
84MAP2K30.54784110
85SCYL20.54180652
86SGK30.53113256
87MAP2K60.52801329
88PDPK10.52659753
89PIK3CG0.51999989
90PTK2B0.51761396
91RPS6KL10.50279145
92RPS6KC10.50279145
93IRAK20.48552866
94MAP2K40.48314290
95MAP3K70.47862160
96KSR20.46871476
97PAK40.46328074
98HIPK20.45361866
99STK110.45322410
100CAMKK20.44992356
101MAP3K50.44250198
102CDK60.44151973
103ACVR1B0.42762466
104PTK60.42340500
105DYRK1B0.41754441
106CDK190.41740590
107GRK60.41381784
108FYN0.41240664
109DAPK20.39930300
110KSR10.37460954
111IRAK10.36345382
112SMG10.35911603
113PKN20.35272488
114SIK10.35105012
115PRKG20.33940776
116SGK20.33722159
117RPS6KA60.33625021
118MAP3K10.33425822
119DMPK0.33242400
120TESK10.33006307
121DAPK30.32946277
122MAP3K20.32284853
123MAPKAPK20.31942495
124RET0.31729197
125FGFR40.30238482
126RAF10.30036393
127STK240.29341516
128ERBB40.29040936
129EPHA30.28075336
130CAMK1D0.27473447
131STK30.26886907
132IGF1R0.26506286
133RPS6KA20.26059322

Predicted pathways (KEGG)

RankGene SetZ-score
1Leishmaniasis_Homo sapiens_hsa051403.55351147
2Graft-versus-host disease_Homo sapiens_hsa053323.47339527
3Staphylococcus aureus infection_Homo sapiens_hsa051502.77362895
4Legionellosis_Homo sapiens_hsa051342.61992353
5Rheumatoid arthritis_Homo sapiens_hsa053232.61811717
6Osteoclast differentiation_Homo sapiens_hsa043802.55071061
7Lysosome_Homo sapiens_hsa041422.52622275
8Toll-like receptor signaling pathway_Homo sapiens_hsa046202.51415645
9* Tuberculosis_Homo sapiens_hsa051522.45715130
10Malaria_Homo sapiens_hsa051442.38970176
11NF-kappa B signaling pathway_Homo sapiens_hsa040642.28799649
12Pertussis_Homo sapiens_hsa051332.24093643
13Allograft rejection_Homo sapiens_hsa053302.20661277
14NOD-like receptor signaling pathway_Homo sapiens_hsa046212.19732055
15Phagosome_Homo sapiens_hsa041452.15365942
16Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.96044651
17Salmonella infection_Homo sapiens_hsa051321.87798441
18Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.85305769
19Type I diabetes mellitus_Homo sapiens_hsa049401.81276808
20B cell receptor signaling pathway_Homo sapiens_hsa046621.78562528
21Measles_Homo sapiens_hsa051621.76204065
22Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.72177475
23Glycosaminoglycan degradation_Homo sapiens_hsa005311.68471737
24Antigen processing and presentation_Homo sapiens_hsa046121.67278947
25TNF signaling pathway_Homo sapiens_hsa046681.66666187
26RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.65565311
27Other glycan degradation_Homo sapiens_hsa005111.61925629
28Hematopoietic cell lineage_Homo sapiens_hsa046401.56057513
29Intestinal immune network for IgA production_Homo sapiens_hsa046721.52229183
30Toxoplasmosis_Homo sapiens_hsa051451.51886574
31Chemokine signaling pathway_Homo sapiens_hsa040621.50541500
32Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.50428716
33Asthma_Homo sapiens_hsa053101.49981997
34Influenza A_Homo sapiens_hsa051641.48945288
35Collecting duct acid secretion_Homo sapiens_hsa049661.45725810
36Apoptosis_Homo sapiens_hsa042101.41053044
37Shigellosis_Homo sapiens_hsa051311.40682419
38Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.39752623
39Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.39642257
40Viral myocarditis_Homo sapiens_hsa054161.31833922
41Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.29458436
42African trypanosomiasis_Homo sapiens_hsa051431.27913009
43Jak-STAT signaling pathway_Homo sapiens_hsa046301.20536927
44Leukocyte transendothelial migration_Homo sapiens_hsa046701.18000411
45AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.12698620
46Herpes simplex infection_Homo sapiens_hsa051681.05045708
47Primary immunodeficiency_Homo sapiens_hsa053401.03918994
48T cell receptor signaling pathway_Homo sapiens_hsa046601.00152353
49Amoebiasis_Homo sapiens_hsa051460.99356269
50Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.97578392
51Hepatitis B_Homo sapiens_hsa051610.94685457
52Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.93546010
53Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.91729329
54Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.90212656
55Autoimmune thyroid disease_Homo sapiens_hsa053200.89446114
56Non-small cell lung cancer_Homo sapiens_hsa052230.87040635
57Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.84275015
58Acute myeloid leukemia_Homo sapiens_hsa052210.84099341
59Platelet activation_Homo sapiens_hsa046110.75694441
60Hepatitis C_Homo sapiens_hsa051600.69996217
61Neurotrophin signaling pathway_Homo sapiens_hsa047220.69557779
62Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.68710101
63Pancreatic cancer_Homo sapiens_hsa052120.68217199
64Vibrio cholerae infection_Homo sapiens_hsa051100.65433427
65Prion diseases_Homo sapiens_hsa050200.64643870
66Notch signaling pathway_Homo sapiens_hsa043300.64221053
67Chronic myeloid leukemia_Homo sapiens_hsa052200.64039977
68Phospholipase D signaling pathway_Homo sapiens_hsa040720.63577204
69Adipocytokine signaling pathway_Homo sapiens_hsa049200.61632199
70* Complement and coagulation cascades_Homo sapiens_hsa046100.58114775
71Prolactin signaling pathway_Homo sapiens_hsa049170.55855466
72GnRH signaling pathway_Homo sapiens_hsa049120.54375540
73Sphingolipid signaling pathway_Homo sapiens_hsa040710.54346404
74Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.46993263
75Type II diabetes mellitus_Homo sapiens_hsa049300.43687160
76Choline metabolism in cancer_Homo sapiens_hsa052310.43278774
77Epstein-Barr virus infection_Homo sapiens_hsa051690.43192758
78Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.43087669
79* Regulation of actin cytoskeleton_Homo sapiens_hsa048100.43081643
80SNARE interactions in vesicular transport_Homo sapiens_hsa041300.42411395
81Phosphatidylinositol signaling system_Homo sapiens_hsa040700.41844887
82Insulin resistance_Homo sapiens_hsa049310.41123666
83MAPK signaling pathway_Homo sapiens_hsa040100.41046611
84Endocytosis_Homo sapiens_hsa041440.40978970
85VEGF signaling pathway_Homo sapiens_hsa043700.40383659
86Rap1 signaling pathway_Homo sapiens_hsa040150.39180854
87Endometrial cancer_Homo sapiens_hsa052130.38881024
88HIF-1 signaling pathway_Homo sapiens_hsa040660.38150003
89Renin-angiotensin system_Homo sapiens_hsa046140.36848961
90Bladder cancer_Homo sapiens_hsa052190.33948350
91Carbohydrate digestion and absorption_Homo sapiens_hsa049730.32964966
92Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.32684648
93Inositol phosphate metabolism_Homo sapiens_hsa005620.31483524
94Proteoglycans in cancer_Homo sapiens_hsa052050.31200458
95Glycerophospholipid metabolism_Homo sapiens_hsa005640.30250053
96Regulation of autophagy_Homo sapiens_hsa041400.30044135
97Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.29437335
98Viral carcinogenesis_Homo sapiens_hsa052030.29081538
99Estrogen signaling pathway_Homo sapiens_hsa049150.28991067
100Mineral absorption_Homo sapiens_hsa049780.27515229
101Caffeine metabolism_Homo sapiens_hsa002320.27505413
102Dorso-ventral axis formation_Homo sapiens_hsa043200.27417485
103Sphingolipid metabolism_Homo sapiens_hsa006000.27251183
104Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.27131700
105Pentose and glucuronate interconversions_Homo sapiens_hsa000400.26354846
106Steroid biosynthesis_Homo sapiens_hsa001000.25964321
107Renal cell carcinoma_Homo sapiens_hsa052110.25360419
108HTLV-I infection_Homo sapiens_hsa051660.22596554
109FoxO signaling pathway_Homo sapiens_hsa040680.22044699
110Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.21539142
111Transcriptional misregulation in cancer_Homo sapiens_hsa052020.20509722
112Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.18719528
113Adherens junction_Homo sapiens_hsa045200.17679785
114Small cell lung cancer_Homo sapiens_hsa052220.17672309
115mTOR signaling pathway_Homo sapiens_hsa041500.16355792
116Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.16184013

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