ITGB1P1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cell adhesion mediated by integrin (GO:0033627)6.84496122
2skin morphogenesis (GO:0043589)6.18635416
3mesodermal cell differentiation (GO:0048333)5.71166639
4cellular response to vitamin D (GO:0071305)5.50321850
5hemidesmosome assembly (GO:0031581)5.37814059
6sequestering of extracellular ligand from receptor (GO:0035581)4.99400034
7substrate-dependent cell migration (GO:0006929)4.85186851
8cellular response to vitamin (GO:0071295)4.60255270
9COPI coating of Golgi vesicle (GO:0048205)4.33586902
10Golgi transport vesicle coating (GO:0048200)4.33586902
11type B pancreatic cell proliferation (GO:0044342)4.29443929
12collagen fibril organization (GO:0030199)4.29295817
13chondrocyte proliferation (GO:0035988)4.13639044
14regulation of branching involved in salivary gland morphogenesis (GO:0060693)4.13159578
15regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)4.12880381
16COPII vesicle coating (GO:0048208)4.04699949
17endodermal cell differentiation (GO:0035987)4.01003732
18desmosome organization (GO:0002934)3.85675353
19regulation of integrin-mediated signaling pathway (GO:2001044)3.84578757
20basement membrane organization (GO:0071711)3.72900436
21wound healing, spreading of epidermal cells (GO:0035313)3.63377490
22cell migration involved in sprouting angiogenesis (GO:0002042)3.60715054
23regulation of vascular endothelial growth factor signaling pathway (GO:1900746)3.58866536
24kidney mesenchyme development (GO:0072074)3.58150117
25muscle cell migration (GO:0014812)3.48477459
26ER overload response (GO:0006983)3.47335092
27lymphangiogenesis (GO:0001946)3.45037977
28mesenchymal-epithelial cell signaling (GO:0060638)3.37391514
29negative regulation of pathway-restricted SMAD protein phosphorylation (GO:0060394)3.30645708
30protein maturation by protein folding (GO:0022417)3.30467896
31response to gravity (GO:0009629)3.29872802
32protein heterotrimerization (GO:0070208)3.28062633
33positive regulation of endothelial cell apoptotic process (GO:2000353)3.28012838
34regulation of extracellular matrix disassembly (GO:0010715)3.26460919
35cell-substrate junction assembly (GO:0007044)3.24117476
36hypotonic response (GO:0006971)3.22466704
37regulation of type B pancreatic cell apoptotic process (GO:2000674)3.14823998
38heparan sulfate proteoglycan biosynthetic process (GO:0015012)3.14382065
39extracellular regulation of signal transduction (GO:1900115)3.13312630
40extracellular negative regulation of signal transduction (GO:1900116)3.13312630
41blood vessel maturation (GO:0001955)3.08244112
42wound healing, spreading of cells (GO:0044319)3.08125992
43positive regulation of positive chemotaxis (GO:0050927)3.07123696
44regulation of positive chemotaxis (GO:0050926)3.04470694
45heparin biosynthetic process (GO:0030210)3.01121411
46heparin metabolic process (GO:0030202)3.01121411
47angiogenesis involved in wound healing (GO:0060055)2.97826945
48negative chemotaxis (GO:0050919)2.96681010
49negative regulation of axon extension involved in axon guidance (GO:0048843)2.95667227
50thrombin receptor signaling pathway (GO:0070493)2.92907417
51regulation of plasminogen activation (GO:0010755)2.92159239
52bundle of His cell to Purkinje myocyte communication (GO:0086069)2.91850175
53regulation of collagen metabolic process (GO:0010712)2.90879488
54positive regulation of interleukin-8 secretion (GO:2000484)2.89597904
55negative regulation of nitric-oxide synthase activity (GO:0051001)2.89038638
56regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022352.88897333
57membrane raft organization (GO:0031579)2.88024347
58sprouting angiogenesis (GO:0002040)2.87997983
59keratan sulfate catabolic process (GO:0042340)2.87567161
60positive regulation of protein autophosphorylation (GO:0031954)2.86430608
61metanephric mesenchyme development (GO:0072075)2.84252868
62response to redox state (GO:0051775)2.83942818
63regulation of metalloenzyme activity (GO:0048552)2.83775238
64chondrocyte development (GO:0002063)2.82780974
65negative regulation of smooth muscle cell migration (GO:0014912)2.82501639
66bone trabecula formation (GO:0060346)2.82239629
67regulation of interleukin-8 secretion (GO:2000482)2.80283903
68vesicle coating (GO:0006901)2.80140882
69collagen metabolic process (GO:0032963)2.79502620
70regulation of apoptotic process involved in morphogenesis (GO:1902337)2.77044281
71extracellular matrix disassembly (GO:0022617)2.76561131
72extracellular fibril organization (GO:0043206)2.76227488
73substrate adhesion-dependent cell spreading (GO:0034446)2.76151739
74fibrinolysis (GO:0042730)2.75937844
75regulation of transmission of nerve impulse (GO:0051969)2.75488129
76vascular endothelial growth factor signaling pathway (GO:0038084)2.73759982
77smooth muscle tissue development (GO:0048745)2.73186663
78protein hydroxylation (GO:0018126)2.72736829
79extracellular matrix assembly (GO:0085029)2.69853469
80regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)2.69602396
81collagen catabolic process (GO:0030574)2.67713731
82retina vasculature morphogenesis in camera-type eye (GO:0061299)2.67127583
83cell migration involved in heart development (GO:0060973)2.66440810
84extracellular matrix organization (GO:0030198)2.66418952
85protein localization to cell surface (GO:0034394)2.66310768
86extracellular structure organization (GO:0043062)2.65313596
87actin filament depolymerization (GO:0030042)2.64482519
88platelet degranulation (GO:0002576)2.63726611
89membrane protein ectodomain proteolysis (GO:0006509)2.61099925
90face morphogenesis (GO:0060325)2.60669311
91regulation of transforming growth factor beta2 production (GO:0032909)2.59307353
92maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.58182136
93pericardium development (GO:0060039)2.57525455
94positive regulation of collagen biosynthetic process (GO:0032967)2.57447730
95stress fiber assembly (GO:0043149)2.56886448
96positive regulation of osteoblast proliferation (GO:0033690)2.55828958
97negative regulation of chondrocyte differentiation (GO:0032331)2.54938783
98wound healing (GO:0042060)2.54888549
99regulation of endothelial cell apoptotic process (GO:2000351)2.54805449
100multicellular organismal macromolecule metabolic process (GO:0044259)2.49067592

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human4.92006893
2TRIM28_21343339_ChIP-Seq_HEK293_Human4.58711764
3SMAD_19615063_ChIP-ChIP_OVARY_Human3.86518088
4PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse3.85736141
5SMAD4_19686287_ChIP-ChIP_HaCaT_Human3.85055671
6TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse3.49848222
7BRD4_25478319_ChIP-Seq_HGPS_Human3.25800414
8CJUN_26792858_Chip-Seq_BT549_Human3.20029595
9FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.96017907
10GATA2_21666600_ChIP-Seq_HMVEC_Human2.93989668
11FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.92635454
12RARG_19884340_ChIP-ChIP_MEFs_Mouse2.66897022
13CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse2.49452696
14SMAD3_18955504_ChIP-ChIP_HaCaT_Human2.49070504
15SMAD2_18955504_ChIP-ChIP_HaCaT_Human2.49070504
16EP300_21415370_ChIP-Seq_HL-1_Mouse2.46870671
17STAT6_21828071_ChIP-Seq_BEAS2B_Human2.45133348
18WT1_19549856_ChIP-ChIP_CCG9911_Human2.44367944
19JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human2.33406071
20ATF3_23680149_ChIP-Seq_GBM1-GSC_Human2.32678041
21TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human2.28681202
22PPAR_26484153_Chip-Seq_NCI-H1993_Human2.20395346
23JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human2.14143752
24ESR1_22446102_ChIP-Seq_UTERUS_Mouse2.07984644
25TP53_16413492_ChIP-PET_HCT116_Human2.04256385
26HIF1A_21447827_ChIP-Seq_MCF-7_Human2.02522034
27CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse2.02494403
28TP53_18474530_ChIP-ChIP_U2OS_Human1.90867702
29MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.90769522
30CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.82924455
31SOX2_20726797_ChIP-Seq_SW620_Human1.79761335
32ZNF217_24962896_ChIP-Seq_MCF-7_Human1.77800948
33RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.67765834
34CDX2_19796622_ChIP-Seq_MESCs_Mouse1.67595234
35NRF2_20460467_ChIP-Seq_MEFs_Mouse1.62819439
36NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.62819439
37FOXO3_23340844_ChIP-Seq_DLD1_Human1.60170051
38SALL4_18804426_ChIP-ChIP_XEN_Mouse1.56261537
39GBX2_23144817_ChIP-Seq_PC3_Human1.53896236
40ELK1_19687146_ChIP-ChIP_HELA_Human1.47743180
41ZFP57_27257070_Chip-Seq_ESCs_Mouse1.44465502
42TP63_23658742_ChIP-Seq_EP156T_Human1.42458254
43ELK1_22589737_ChIP-Seq_MCF10A_Human1.37646898
44HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.31990671
45SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.31086703
46TCF4_18268006_ChIP-ChIP_LS174T_Human1.27499631
47PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.25672863
48FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.21656355
49NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.19794528
50CDX2_22108803_ChIP-Seq_LS180_Human1.19047470
51RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.16546267
52AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.15821982
53AHR_22903824_ChIP-Seq_MCF-7_Human1.15612136
54FOXM1_26456572_ChIP-Seq_MCF-7_Human1.13986880
55SOX9_24532713_ChIP-Seq_HFSC_Mouse1.13550557
56PIAS1_25552417_ChIP-Seq_VCAP_Human1.12066311
57Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.10454600
58PCGF2_27294783_Chip-Seq_ESCs_Mouse1.10359981
59FLI1_27457419_Chip-Seq_LIVER_Mouse1.05565909
60P63_26484246_Chip-Seq_KERATINOCYTES_Human1.03544754
61EED_16625203_ChIP-ChIP_MESCs_Mouse1.01382561
62ARNT_22903824_ChIP-Seq_MCF-7_Human0.99052344
63KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.98877149
64RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.98391390
65EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.97766835
66SOX17_20123909_ChIP-Seq_XEN_Mouse0.96909175
67TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.95789687
68ESR1_21235772_ChIP-Seq_MCF-7_Human0.95747998
69SMAD4_21799915_ChIP-Seq_A2780_Human0.93559105
70SUZ12_27294783_Chip-Seq_NPCs_Mouse0.93197493
71EZH2_27294783_Chip-Seq_NPCs_Mouse0.92984991
72GATA4_25053715_ChIP-Seq_YYC3_Human0.91338758
73ATF3_27146783_Chip-Seq_COLON_Human0.90659102
74PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.89657653
75PCGF2_27294783_Chip-Seq_NPCs_Mouse0.88715313
76TP53_22127205_ChIP-Seq_IMR90_Human0.88454820
77PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.88223799
78OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.86183269
79GABP_17652178_ChIP-ChIP_JURKAT_Human0.84686049
80UBF1/2_26484160_Chip-Seq_HMECs_Human0.83559118
81GATA3_24758297_ChIP-Seq_MCF-7_Human0.82734530
82RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.80933339
83EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.79194392
84SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.78872012
85NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.77947830
86SMC1_22415368_ChIP-Seq_MEFs_Mouse0.77677589
87POU3F2_20337985_ChIP-ChIP_501MEL_Human0.76562761
88SA1_22415368_ChIP-Seq_MEFs_Mouse0.76510158
89ELK3_25401928_ChIP-Seq_HUVEC_Human0.75496875
90CLOCK_20551151_ChIP-Seq_293T_Human0.75307530
91PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.74906697
92NFI_21473784_ChIP-Seq_ESCs_Mouse0.73490712
93GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.73308314
94KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.71799903
95FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.70494910
96SRF_21415370_ChIP-Seq_HL-1_Mouse0.69691309
97NFE2_27457419_Chip-Seq_LIVER_Mouse0.69510154
98SOX9_26525672_Chip-Seq_Limbbuds_Mouse0.68977271
99ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.68633799
100NR3C1_23031785_ChIP-Seq_PC12_Mouse0.67823415

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen6.67446205
2MP0004272_abnormal_basement_membrane4.51545699
3MP0010368_abnormal_lymphatic_system3.99025165
4MP0005275_abnormal_skin_tensile3.66407015
5MP0003566_abnormal_cell_adhesion3.51954476
6MP0003950_abnormal_plasma_membrane3.38853910
7MP0003279_aneurysm3.17504979
8MP0005503_abnormal_tendon_morphology2.95893150
9MP0006054_spinal_hemorrhage2.82840430
10MP0005623_abnormal_meninges_morphology2.76926783
11MP0009780_abnormal_chondrocyte_physiolo2.64795618
12MP0000013_abnormal_adipose_tissue2.60964469
13MP0001958_emphysema2.54794255
14MP0002295_abnormal_pulmonary_circulatio2.47096112
15MP0005257_abnormal_intraocular_pressure2.45839698
16MP0001542_abnormal_bone_strength2.40959006
17MP0005023_abnormal_wound_healing2.39442922
18MP0003705_abnormal_hypodermis_morpholog2.35554297
19MP0002060_abnormal_skin_morphology2.14726468
20MP0001879_abnormal_lymphatic_vessel2.11550436
21MP0010352_gastrointestinal_tract_polyps1.97270387
22MP0003941_abnormal_skin_development1.91439807
23MP0000569_abnormal_digit_pigmentation1.75203064
24MP0004134_abnormal_chest_morphology1.67331861
25MP0000767_abnormal_smooth_muscle1.66256799
26MP0010386_abnormal_urinary_bladder1.65938127
27MP0009697_abnormal_copulation1.62019272
28MP0003091_abnormal_cell_migration1.61682192
29MP0009250_abnormal_appendicular_skeleto1.58850682
30MP0002896_abnormal_bone_mineralization1.57879651
31MP0005508_abnormal_skeleton_morphology1.55180590
32MP0009384_cardiac_valve_regurgitation1.51727828
33MP0009053_abnormal_anal_canal1.49686501
34MP0005084_abnormal_gallbladder_morpholo1.34801147
35MP0001243_abnormal_dermal_layer1.32027824
36MP0002877_abnormal_melanocyte_morpholog1.29423394
37MP0004084_abnormal_cardiac_muscle1.29046944
38MP0005595_abnormal_vascular_smooth1.23848527
39MP0003300_gastrointestinal_ulcer1.22353241
40MP0005408_hypopigmentation1.21345607
41MP0005164_abnormal_response_to1.20298377
42MP0005464_abnormal_platelet_physiology1.17282161
43MP0000762_abnormal_tongue_morphology1.16604881
44MP0000003_abnormal_adipose_tissue1.14118003
45MP0005165_increased_susceptibility_to1.13717515
46MP0000467_abnormal_esophagus_morphology1.12874189
47MP0005390_skeleton_phenotype1.04634620
48MP0003448_altered_tumor_morphology1.03118085
49MP0004510_myositis1.02783066
50MP0000534_abnormal_ureter_morphology0.99171252
51MP0005409_darkened_coat_color0.99066842
52MP0005083_abnormal_biliary_tract0.98597579
53MP0002108_abnormal_muscle_morphology0.95074656
54MP0002177_abnormal_outer_ear0.93241920
55MP0000163_abnormal_cartilage_morphology0.91433397
56MP0009840_abnormal_foam_cell0.88444372
57MP0003868_abnormal_feces_composition0.85372246
58MP0002168_other_aberrant_phenotype0.84739320
59MP0008775_abnormal_heart_ventricle0.84203898
60MP0002128_abnormal_blood_circulation0.82867018
61MP0000733_abnormal_muscle_development0.80312960
62MP0001614_abnormal_blood_vessel0.79430797
63MP0000538_abnormal_urinary_bladder0.79396032
64MP0010771_integument_phenotype0.79017159
65MP0003045_fibrosis0.78069259
66MP0000858_altered_metastatic_potential0.77759983
67MP0001299_abnormal_eye_distance/0.77434914
68MP0000627_abnormal_mammary_gland0.77161913
69MP0001216_abnormal_epidermal_layer0.76037971
70MP0005197_abnormal_uvea_morphology0.73995082
71MP0004036_abnormal_muscle_relaxation0.73976979
72MP0002115_abnormal_skeleton_extremities0.71866708
73MP0003795_abnormal_bone_structure0.71783315
74MP0010030_abnormal_orbit_morphology0.70547113
75MP0002998_abnormal_bone_remodeling0.69229706
76MP0001661_extended_life_span0.69052507
77MP0002113_abnormal_skeleton_development0.67326786
78MP0003942_abnormal_urinary_system0.65890301
79MP0001533_abnormal_skeleton_physiology0.65885792
80MP0001853_heart_inflammation0.65775091
81MP0005193_abnormal_anterior_eye0.64297765
82MP0001915_intracranial_hemorrhage0.64205040
83MP0001944_abnormal_pancreas_morphology0.63753805
84MP0003283_abnormal_digestive_organ0.63191507
85MP0005501_abnormal_skin_physiology0.62960584
86MP0000249_abnormal_blood_vessel0.61144548
87MP0000015_abnormal_ear_pigmentation0.60674630
88MP0004233_abnormal_muscle_weight0.59849413
89MP0000428_abnormal_craniofacial_morphol0.59705378
90MP0002925_abnormal_cardiovascular_devel0.59588852
91MP0001756_abnormal_urination0.59059301
92MP0001666_abnormal_nutrient_absorption0.58902391
93MP0003191_abnormal_cellular_cholesterol0.56450261
94MP0000465_gastrointestinal_hemorrhage0.54847597
95MP0001881_abnormal_mammary_gland0.54199394
96MP0004883_abnormal_blood_vessel0.53921838
97MP0003385_abnormal_body_wall0.51941152
98MP0003755_abnormal_palate_morphology0.51787570
99MP0000230_abnormal_systemic_arterial0.51535894
100MP0003937_abnormal_limbs/digits/tail_de0.50931738

Predicted human phenotypes

RankGene SetZ-score
1Premature rupture of membranes (HP:0001788)7.18355586
2Protrusio acetabuli (HP:0003179)6.24739803
3Aortic dissection (HP:0002647)4.98759691
4Vascular tortuosity (HP:0004948)4.96083492
5Atrophic scars (HP:0001075)4.93408653
6Follicular hyperkeratosis (HP:0007502)4.77883304
7Arterial tortuosity (HP:0005116)4.44014413
8Aortic aneurysm (HP:0004942)4.18829301
9Cardiovascular calcification (HP:0011915)4.07374206
10Spondylolisthesis (HP:0003302)4.06938259
11Abnormality of dentin (HP:0010299)3.98053616
12Soft skin (HP:0000977)3.86614842
13Fragile skin (HP:0001030)3.64379766
14Cervical subluxation (HP:0003308)3.60696060
15Ankle contracture (HP:0006466)3.51897243
16Vascular calcification (HP:0004934)3.44550993
17Wormian bones (HP:0002645)3.38833829
18Bladder diverticulum (HP:0000015)3.20773144
19Menorrhagia (HP:0000132)3.17730232
20Spinal rigidity (HP:0003306)3.14983376
21Vertebral compression fractures (HP:0002953)3.02820664
22Genu recurvatum (HP:0002816)2.90974556
23Overgrowth (HP:0001548)2.73656191
24Peritonitis (HP:0002586)2.72999341
25Aortic regurgitation (HP:0001659)2.70795235
26Aortic valve stenosis (HP:0001650)2.62083131
27Dilatation of the ascending aorta (HP:0005111)2.56104103
28Blue sclerae (HP:0000592)2.53697207
29Slender build (HP:0001533)2.50902186
30Abnormality of the acetabulum (HP:0003170)2.45356872
31Mitral stenosis (HP:0001718)2.44781482
32Increased mean platelet volume (HP:0011877)2.44025187
33Entropion (HP:0000621)2.43983642
34Type 1 muscle fiber predominance (HP:0003803)2.40495187
35Reduced subcutaneous adipose tissue (HP:0003758)2.39647732
36Elbow flexion contracture (HP:0002987)2.37974506
37Joint stiffness (HP:0001387)2.33301008
38Mitral valve prolapse (HP:0001634)2.31341763
39Ovoid vertebral bodies (HP:0003300)2.31016511
40Nonimmune hydrops fetalis (HP:0001790)2.29668535
41Osteolytic defects of the hand bones (HP:0009699)2.27928791
42Osteolytic defects of the phalanges of the hand (HP:0009771)2.27928791
43Abnormality of glycosaminoglycan metabolism (HP:0004371)2.27810024
44Abnormality of mucopolysaccharide metabolism (HP:0011020)2.27810024
45Abnormality of polysaccharide metabolism (HP:0011012)2.27810024
46Mucopolysacchariduria (HP:0008155)2.27135018
47Urinary glycosaminoglycan excretion (HP:0003541)2.27135018
48Joint laxity (HP:0001388)2.25743800
49Onycholysis (HP:0001806)2.23439443
50Facial diplegia (HP:0001349)2.21549812
51Tibial bowing (HP:0002982)2.21209529
52Short nail (HP:0001799)2.14551726
53Femoral bowing (HP:0002980)2.14112986
54Radial bowing (HP:0002986)2.12727606
55Petechiae (HP:0000967)2.11886310
56Neonatal short-limb short stature (HP:0008921)2.11827546
57Thoracolumbar scoliosis (HP:0002944)2.11364320
58Fragile nails (HP:0001808)2.09526052
59Shallow orbits (HP:0000586)2.09268430
60Bowel diverticulosis (HP:0005222)2.07703907
61Hyperextensible skin (HP:0000974)2.07110960
62Keratoconus (HP:0000563)2.06433676
63Increased corneal curvature (HP:0100692)2.06433676
64Delayed gross motor development (HP:0002194)2.03087465
65Abnormal platelet volume (HP:0011876)1.97862296
66Alopecia of scalp (HP:0002293)1.96481936
67Broad metatarsal (HP:0001783)1.94770178
68Right ventricular cardiomyopathy (HP:0011663)1.94759424
69Abnormal delivery (HP:0001787)1.93041915
70Metaphyseal dysplasia (HP:0100255)1.91057206
71Milia (HP:0001056)1.90013741
72Cerebral aneurysm (HP:0004944)1.88942136
73Generalized amyotrophy (HP:0003700)1.88646269
74Biconcave vertebral bodies (HP:0004586)1.87157329
75Aneurysm (HP:0002617)1.85550028
76Abnormal umbilical cord blood vessels (HP:0011403)1.84632769
77Single umbilical artery (HP:0001195)1.84632769
78Abnormality of the fetal cardiovascular system (HP:0010948)1.84632769
79Wrist flexion contracture (HP:0001239)1.83414995
80Gingival bleeding (HP:0000225)1.80948349
81Flared iliac wings (HP:0002869)1.80831500
82Coxa vara (HP:0002812)1.80298298
83Bruising susceptibility (HP:0000978)1.79246417
84Natal tooth (HP:0000695)1.78754244
85Mitral regurgitation (HP:0001653)1.77354251
86Ectopia lentis (HP:0001083)1.75947830
87Upper limb amyotrophy (HP:0009129)1.74577432
88Distal upper limb amyotrophy (HP:0007149)1.74577432
89Protruding ear (HP:0000411)1.73963072
90Hypoplasia of the odontoid process (HP:0003311)1.73281077
91Knee flexion contracture (HP:0006380)1.70887062
92Abnormality of the odontoid process (HP:0003310)1.70749693
93Decreased subcutaneous fat (HP:0001002)1.70297329
94Abnormality of skeletal muscle fiber size (HP:0012084)1.69294142
95Osteopenia (HP:0000938)1.67646347
96Hypoventilation (HP:0002791)1.64535046
97Bowed forearm bones (HP:0003956)1.64398689
98Bowing of the arm (HP:0006488)1.64398689
99Conjugated hyperbilirubinemia (HP:0002908)1.63948470
100Pectus carinatum (HP:0000768)1.63589427

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MYLK4.21734884
2TGFBR22.94850571
3MST42.81445327
4EPHA22.65739101
5MAP3K122.64430829
6PTK22.63129214
7MET2.58015043
8MST1R2.57938137
9ARAF2.55223055
10PDGFRA2.41617025
11TIE12.33717115
12TESK12.33072912
13LIMK12.24472938
14PAK42.06146751
15FLT31.99523480
16TRPM71.95781895
17PIK3CG1.87675958
18EPHB21.80890057
19NTRK11.77303687
20DDR21.76008648
21PIM21.68161158
22MOS1.60803146
23KDR1.56646530
24AKT31.55909075
25LMTK21.54999677
26ERBB41.46509177
27GRK11.43849670
28PTK2B1.43245519
29PDGFRB1.39392603
30VRK21.38611362
31PAK21.36302410
32EIF2AK31.29444337
33EIF2AK11.25857175
34ADRBK21.24292697
35IRAK31.17253626
36WNK11.12630823
37FER1.11149162
38ADRBK11.10579227
39STK381.07596858
40PLK21.06893400
41STK101.06793710
42ROCK11.06762587
43MAP3K31.05273069
44GRK71.04540907
45RIPK11.00509693
46PRKCE0.98742889
47MUSK0.98648539
48STK30.95325304
49NEK90.92406845
50INSRR0.90412734
51WNK40.90238911
52STK160.87662144
53PRKG20.87473336
54MAPKAPK30.85843659
55ERN10.85499252
56PRKD20.85330504
57MAP2K10.84177797
58CDK80.82460796
59BRSK20.81637535
60ILK0.81483957
61PAK30.81151552
62MAP3K90.74941240
63CAMK1G0.74106660
64ABL20.70838086
65LATS20.69459904
66CDK90.68720170
67ROCK20.63719508
68TEC0.63032423
69GRK50.62193103
70PHKG10.57998557
71PHKG20.57998557
72CSNK1G10.57738306
73MAP3K20.57662075
74EPHB10.56355113
75FRK0.55484114
76TTN0.54194932
77PIK3CA0.53990764
78GSK3A0.53607235
79SIK10.53110881
80CSNK1A1L0.52109766
81LATS10.49924760
82PNCK0.49237151
83MELK0.48013508
84BMX0.46622381
85CDC42BPA0.45147300
86RPS6KA20.44812176
87INSR0.44681189
88DAPK30.44196309
89PAK10.41641830
90NUAK10.41274631
91TNIK0.40235456
92JAK30.38336063
93CSNK1G30.37944468
94PRKCI0.37631412
95STK390.36326207
96MAPK110.34652476
97MAPKAPK20.34450735
98IGF1R0.34062775
99SCYL20.33055821
100CDK120.32245635

Predicted pathways (KEGG)

RankGene SetZ-score
1ECM-receptor interaction_Homo sapiens_hsa045124.71138809
2Sulfur metabolism_Homo sapiens_hsa009203.93424360
3Glycosaminoglycan degradation_Homo sapiens_hsa005313.11630052
4Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005322.95126408
5Protein export_Homo sapiens_hsa030602.93742489
6Focal adhesion_Homo sapiens_hsa045102.89952155
7Proteasome_Homo sapiens_hsa030502.45814440
8Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005342.23826511
9Protein processing in endoplasmic reticulum_Homo sapiens_hsa041412.15995827
10Bacterial invasion of epithelial cells_Homo sapiens_hsa051002.09309478
11Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054122.07678355
12Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054102.07516798
13Vibrio cholerae infection_Homo sapiens_hsa051101.83402065
14N-Glycan biosynthesis_Homo sapiens_hsa005101.82503965
15Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.73753098
16Protein digestion and absorption_Homo sapiens_hsa049741.73410719
17Adherens junction_Homo sapiens_hsa045201.73012695
18Proteoglycans in cancer_Homo sapiens_hsa052051.72774168
19Selenocompound metabolism_Homo sapiens_hsa004501.69538062
20TGF-beta signaling pathway_Homo sapiens_hsa043501.69399812
21Dilated cardiomyopathy_Homo sapiens_hsa054141.69164220
22Regulation of actin cytoskeleton_Homo sapiens_hsa048101.66639668
23Small cell lung cancer_Homo sapiens_hsa052221.65830423
24Amoebiasis_Homo sapiens_hsa051461.57615897
25Maturity onset diabetes of the young_Homo sapiens_hsa049501.48960120
26PI3K-Akt signaling pathway_Homo sapiens_hsa041511.47106154
27Complement and coagulation cascades_Homo sapiens_hsa046101.43520882
28Shigellosis_Homo sapiens_hsa051311.38207516
29Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.28658821
30Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.21702664
31Lysosome_Homo sapiens_hsa041421.18317734
32Melanoma_Homo sapiens_hsa052181.17161540
33AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.17051506
34Platelet activation_Homo sapiens_hsa046111.16975593
35Malaria_Homo sapiens_hsa051441.14601264
36Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.14169242
37Sphingolipid metabolism_Homo sapiens_hsa006001.06857592
38Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.04765938
39Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.00651927
40Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.00548875
41Bladder cancer_Homo sapiens_hsa052190.99579090
42Fatty acid elongation_Homo sapiens_hsa000620.98145919
43Hematopoietic cell lineage_Homo sapiens_hsa046400.97618467
44Basal transcription factors_Homo sapiens_hsa030220.92846235
45Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.91344275
46Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.90431665
47Other glycan degradation_Homo sapiens_hsa005110.89845196
48Thyroid cancer_Homo sapiens_hsa052160.88027237
49Leukocyte transendothelial migration_Homo sapiens_hsa046700.85515630
50Pathways in cancer_Homo sapiens_hsa052000.81540029
51SNARE interactions in vesicular transport_Homo sapiens_hsa041300.81095834
52Glutathione metabolism_Homo sapiens_hsa004800.80051987
53Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.79073710
54Folate biosynthesis_Homo sapiens_hsa007900.79067159
55Tight junction_Homo sapiens_hsa045300.78398758
56Hippo signaling pathway_Homo sapiens_hsa043900.77648543
57MicroRNAs in cancer_Homo sapiens_hsa052060.75001099
58Dorso-ventral axis formation_Homo sapiens_hsa043200.72813249
59Renin-angiotensin system_Homo sapiens_hsa046140.68157479
60p53 signaling pathway_Homo sapiens_hsa041150.66274917
61Galactose metabolism_Homo sapiens_hsa000520.64990389
62Endocytosis_Homo sapiens_hsa041440.62557655
63Primary bile acid biosynthesis_Homo sapiens_hsa001200.61796264
64Nucleotide excision repair_Homo sapiens_hsa034200.61658886
65Hedgehog signaling pathway_Homo sapiens_hsa043400.60232358
66Circadian rhythm_Homo sapiens_hsa047100.59500789
67Pancreatic secretion_Homo sapiens_hsa049720.58457947
68TNF signaling pathway_Homo sapiens_hsa046680.58110621
69Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.57286166
70Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.56319841
71Rap1 signaling pathway_Homo sapiens_hsa040150.52815929
72Prostate cancer_Homo sapiens_hsa052150.51909106
73Rheumatoid arthritis_Homo sapiens_hsa053230.45959824
74Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.42212028
75Thyroid hormone synthesis_Homo sapiens_hsa049180.41593608
76Wnt signaling pathway_Homo sapiens_hsa043100.41477302
77Steroid hormone biosynthesis_Homo sapiens_hsa001400.40532707
78Mineral absorption_Homo sapiens_hsa049780.40322061
79Axon guidance_Homo sapiens_hsa043600.40047127
80Salmonella infection_Homo sapiens_hsa051320.40009883
81Starch and sucrose metabolism_Homo sapiens_hsa005000.39454620
82One carbon pool by folate_Homo sapiens_hsa006700.36646430
83Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.35527206
84Phagosome_Homo sapiens_hsa041450.35390077
85Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.31447722
86cGMP-PKG signaling pathway_Homo sapiens_hsa040220.31080116
87Vascular smooth muscle contraction_Homo sapiens_hsa042700.30152404
88Retinol metabolism_Homo sapiens_hsa008300.29367720
89Gap junction_Homo sapiens_hsa045400.28539948
90Basal cell carcinoma_Homo sapiens_hsa052170.27961635
91RNA polymerase_Homo sapiens_hsa030200.26426695
92Jak-STAT signaling pathway_Homo sapiens_hsa046300.26102717
93Ras signaling pathway_Homo sapiens_hsa040140.25910185
94Pentose and glucuronate interconversions_Homo sapiens_hsa000400.25611897
95Pertussis_Homo sapiens_hsa051330.25327618
96Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.25056933
97Alzheimers disease_Homo sapiens_hsa050100.22419236
98Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.20881867
99Melanogenesis_Homo sapiens_hsa049160.20714906
100Chemical carcinogenesis_Homo sapiens_hsa052040.20701109

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