ITGB2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes an integrin beta chain, which combines with multiple different alpha chains to form different integrin heterodimers. Integrins are integral cell-surface proteins that participate in cell adhesion as well as cell-surface mediated signalling. The encoded protein plays an important role in immune response and defects in this gene cause leukocyte adhesion deficiency. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.92528611
2modulation by symbiont of host immune response (GO:0052553)5.59226606
3positive regulation by symbiont of host defense response (GO:0052509)5.59226606
4modulation by symbiont of host defense response (GO:0052031)5.59226606
5modulation by organism of immune response of other organism involved in symbiotic interaction (GO:005.59226606
6modulation by organism of defense response of other organism involved in symbiotic interaction (GO:05.59226606
7positive regulation by organism of defense response of other organism involved in symbiotic interact5.59226606
8neutrophil activation involved in immune response (GO:0002283)5.15472999
9positive regulation of gamma-delta T cell activation (GO:0046645)5.12315183
10leukocyte aggregation (GO:0070486)5.11306921
11regulation of B cell receptor signaling pathway (GO:0050855)4.97531549
12negative regulation of cell killing (GO:0031342)4.91221157
13negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.91221157
14respiratory burst (GO:0045730)4.78091653
15detection of other organism (GO:0098543)4.76128276
16response to peptidoglycan (GO:0032494)4.61525101
17detection of bacterium (GO:0016045)4.57241286
18antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.48648899
19antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.48648899
20immunoglobulin mediated immune response (GO:0016064)4.42440024
21cellular extravasation (GO:0045123)4.39505540
22regulation of interferon-beta biosynthetic process (GO:0045357)4.33735725
23antigen processing and presentation of endogenous antigen (GO:0019883)4.32987337
24macrophage activation involved in immune response (GO:0002281)4.15216547
25detection of external biotic stimulus (GO:0098581)4.01328976
26positive regulation of interferon-alpha production (GO:0032727)3.99265693
27positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.93181306
28neutrophil activation (GO:0042119)3.88432894
29negative regulation of lymphocyte mediated immunity (GO:0002707)3.84341146
30granulocyte activation (GO:0036230)3.83923975
31T cell migration (GO:0072678)3.81403108
32response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.81004211
33response to host immune response (GO:0052572)3.81004211
34regulation of interferon-alpha production (GO:0032647)3.80634359
35positive regulation of mast cell activation (GO:0033005)3.75151405
36production of molecular mediator involved in inflammatory response (GO:0002532)3.72077915
37positive regulation of interleukin-8 biosynthetic process (GO:0045416)3.68865795
38positive regulation of antigen processing and presentation (GO:0002579)3.64249271
39myeloid cell activation involved in immune response (GO:0002275)3.61660772
40detection of biotic stimulus (GO:0009595)3.61334650
41negative regulation of leukocyte mediated immunity (GO:0002704)3.56536583
42response to host (GO:0075136)3.54222559
43response to host defenses (GO:0052200)3.54222559
44response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.54222559
45regulation of gamma-delta T cell differentiation (GO:0045586)3.54132548
46regulation of gamma-delta T cell activation (GO:0046643)3.52696236
47negative regulation of interleukin-12 production (GO:0032695)3.51025619
48Arp2/3 complex-mediated actin nucleation (GO:0034314)3.48458933
49positive thymic T cell selection (GO:0045059)3.45778228
50regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.45120433
51negative regulation of T cell mediated immunity (GO:0002710)3.44475664
52regulation of T cell tolerance induction (GO:0002664)3.43785977
53positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.42121873
54positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.40833567
55regulation of B cell differentiation (GO:0045577)3.39171568
56negative thymic T cell selection (GO:0045060)3.38533930
57negative regulation of erythrocyte differentiation (GO:0045647)3.37405900
58response to muramyl dipeptide (GO:0032495)3.35926694
59B cell mediated immunity (GO:0019724)3.35217340
60* leukocyte cell-cell adhesion (GO:0007159)3.35188990
61activated T cell proliferation (GO:0050798)3.34068643
62negative T cell selection (GO:0043383)3.32780385
63hydrogen peroxide biosynthetic process (GO:0050665)3.31664843
64regulation of tolerance induction (GO:0002643)3.30138302
65regulation of mast cell activation (GO:0033003)3.24512226
66regulation of mast cell degranulation (GO:0043304)3.23283280
67interferon-gamma-mediated signaling pathway (GO:0060333)3.19452908
68lipopolysaccharide-mediated signaling pathway (GO:0031663)3.19097879
69positive regulation of B cell differentiation (GO:0045579)3.14885066
70regulation of antigen processing and presentation (GO:0002577)3.14112785
71B cell receptor signaling pathway (GO:0050853)3.10591739
72leukocyte degranulation (GO:0043299)3.10389691
73tolerance induction (GO:0002507)3.10228981
74regulation of antigen receptor-mediated signaling pathway (GO:0050854)3.09889236
75response to type I interferon (GO:0034340)3.09657925
76cellular response to type I interferon (GO:0071357)3.08676997
77type I interferon signaling pathway (GO:0060337)3.08676997
78regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.07744256
79interferon-gamma production (GO:0032609)3.07725196
80defense response to protozoan (GO:0042832)3.07619983
81microglial cell activation (GO:0001774)3.06655625
82negative regulation of cytokine production involved in immune response (GO:0002719)3.06404211
83superoxide anion generation (GO:0042554)3.05996906
84antigen processing and presentation via MHC class Ib (GO:0002475)3.05927441
85regulation of interleukin-12 biosynthetic process (GO:0045075)3.04741676
86neutrophil mediated immunity (GO:0002446)3.02300949
87positive regulation of mast cell degranulation (GO:0043306)3.02007179
88positive regulation of mast cell activation involved in immune response (GO:0033008)3.02007179
89cellular response to zinc ion (GO:0071294)3.01241957
90regulation of tumor necrosis factor biosynthetic process (GO:0042534)3.01146496
91regulation of mast cell activation involved in immune response (GO:0033006)2.99028482
92macrophage activation (GO:0042116)2.97218552
93cellular defense response (GO:0006968)2.96433013
94mast cell activation (GO:0045576)2.95095409
95positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.94955180
96myeloid dendritic cell activation (GO:0001773)2.94813845
97positive regulation of cellular amide metabolic process (GO:0034250)2.94531015
98positive regulation of interferon-beta production (GO:0032728)2.94461003
99regulation of natural killer cell mediated immunity (GO:0002715)2.94388057
100regulation of natural killer cell mediated cytotoxicity (GO:0042269)2.94388057
101reactive oxygen species biosynthetic process (GO:1903409)2.94344399
102T cell selection (GO:0045058)2.93779137
103germinal center formation (GO:0002467)2.92109471
104regulation of dendritic cell antigen processing and presentation (GO:0002604)2.91964466
105negative regulation of interleukin-6 production (GO:0032715)2.90338291
106negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.89588431
107cellular response to interleukin-15 (GO:0071350)2.89428862
108regulation of leukocyte degranulation (GO:0043300)2.88434695
109response to protozoan (GO:0001562)2.88145682
110positive regulation of myeloid leukocyte mediated immunity (GO:0002888)2.87183462
111myeloid leukocyte activation (GO:0002274)2.86969760
112negative regulation of phagocytosis (GO:0050765)2.85604535
113regulation of T cell mediated cytotoxicity (GO:0001914)2.85114892
114negative regulation of innate immune response (GO:0045824)2.84628458
115regulation of myeloid leukocyte mediated immunity (GO:0002886)2.84324657
116regulation of alpha-beta T cell proliferation (GO:0046640)2.84140318
117leukocyte migration involved in inflammatory response (GO:0002523)2.83181643
118myeloid dendritic cell differentiation (GO:0043011)2.82748106
119thymic T cell selection (GO:0045061)2.81548450
120lymphocyte chemotaxis (GO:0048247)2.80665819
121positive regulation of alpha-beta T cell proliferation (GO:0046641)2.80299358
122response to fungus (GO:0009620)2.79475129
123response to interleukin-15 (GO:0070672)2.78174291
124* neutrophil chemotaxis (GO:0030593)2.77966104
125detection of molecule of bacterial origin (GO:0032490)2.77438575
126positive regulation of chemokine biosynthetic process (GO:0045080)2.77368909

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_21731497_ChIP-ChIP_J774_Mouse6.04832138
2BP1_19119308_ChIP-ChIP_Hs578T_Human5.81295159
3IRF8_22096565_ChIP-ChIP_GC-B_Human5.59126482
4FOXP3_17237761_ChIP-ChIP_TREG_Mouse4.53801214
5IRF8_27001747_Chip-Seq_BMDM_Mouse4.06998082
6* STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.97853909
7* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.88003892
8* MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.78187451
9IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.65147084
10* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse3.52203042
11MYB_21317192_ChIP-Seq_ERMYB_Mouse3.26016259
12IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.23495405
13STAT3_20064451_ChIP-Seq_CD4+T_Mouse3.03867771
14SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.93049946
15* Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.88216083
16EGR1_19374776_ChIP-ChIP_THP-1_Human2.88201995
17STAT4_19710469_ChIP-ChIP_TH1__Mouse2.78268549
18NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.56038907
19SPI1_23547873_ChIP-Seq_NB4_Human2.48871791
20* BRD4_27068464_Chip-Seq_AML-cells_Mouse2.43825232
21RUNX_20019798_ChIP-Seq_JUKART_Human2.42978982
22* MYB_26560356_Chip-Seq_TH2_Human2.37028795
23RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.33514670
24FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.27851509
25NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.23102691
26MAF_26560356_Chip-Seq_TH1_Human2.19605451
27* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.18060780
28VDR_21846776_ChIP-Seq_THP-1_Human2.11900797
29* RUNX1_22412390_ChIP-Seq_EML_Mouse2.07081146
30SPI1_23127762_ChIP-Seq_K562_Human2.02760083
31* VDR_24763502_ChIP-Seq_THP-1_Human1.99922936
32MYB_26560356_Chip-Seq_TH1_Human1.94307639
33SCL_19346495_ChIP-Seq_HPC-7_Human1.92721390
34* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.90546297
35MYC_22102868_ChIP-Seq_BL_Human1.90375982
36PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.87695020
37ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.84224767
38* UTX_26944678_Chip-Seq_JUKART_Human1.81558497
39* MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.74590459
40* PU_27001747_Chip-Seq_BMDM_Mouse1.71400829
41* CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.67745989
42* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.66957308
43* CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.63556646
44* FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.60697495
45THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.54232614
46* GATA3_27048872_Chip-Seq_THYMUS_Human1.53862627
47* VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.52202904
48E2F7_22180533_ChIP-Seq_HELA_Human1.51797460
49TCF7_22412390_ChIP-Seq_EML_Mouse1.50424191
50CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.48561241
51VDR_24787735_ChIP-Seq_THP-1_Human1.46436449
52* LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.38675741
53* CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.36112186
54MAF_26560356_Chip-Seq_TH2_Human1.35447148
55GATA1_22025678_ChIP-Seq_K562_Human1.32827774
56PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.32820764
57* CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.32469929
58GATA2_22383799_ChIP-Seq_G1ME_Mouse1.29958020
59STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.29827148
60NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.27909090
61STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.27628103
62GATA3_26560356_Chip-Seq_TH2_Human1.25861615
63* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.21244651
64* PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.20802260
65KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.17943817
66ELK3_25401928_ChIP-Seq_HUVEC_Human1.16698094
67* PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.16601304
68* SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.14958080
69* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.14007531
70LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.12290693
71* KDM2B_26808549_Chip-Seq_JURKAT_Human1.11242161
72SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.11082488
73* KDM2B_26808549_Chip-Seq_DND41_Human1.09405499
74GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.08393594
75* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.07996519
76BCOR_27268052_Chip-Seq_Bcells_Human1.04162904
77* GATA1_22383799_ChIP-Seq_G1ME_Mouse1.02934223
78GATA1_19941827_ChIP-Seq_MEL_Mouse1.01056856
79* TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.97583805
80VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.91822640
81GATA2_21666600_ChIP-Seq_HMVEC_Human0.89985884
82* TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.89938263
83GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.89503118
84TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.88853598
85SPI1_20517297_ChIP-Seq_HL60_Human0.87964274
86TFEB_21752829_ChIP-Seq_HELA_Human0.87872536
87STAT6_21828071_ChIP-Seq_BEAS2B_Human0.85446625
88GATA2_19941826_ChIP-Seq_K562_Human0.85405402
89SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.84432227
90BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.84114190
91LXR_22292898_ChIP-Seq_THP-1_Human0.83134322
92CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.82854148
93NOTCH1_21737748_ChIP-Seq_TLL_Human0.82693360
94PU.1_20513432_ChIP-Seq_Bcells_Mouse0.81982539
95RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.81720240
96CTCF_27219007_Chip-Seq_ERYTHROID_Human0.81672982
97* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.80851358
98GATA1_19941826_ChIP-Seq_K562_Human0.78878149
99TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.75483930
100GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.74198874
101* GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.73743708
102ERG_20887958_ChIP-Seq_HPC-7_Mouse0.73304176
103NCOR1_26117541_ChIP-Seq_K562_Human0.72547981
104HOXB4_20404135_ChIP-ChIP_EML_Mouse0.72156455
105SMAD_19615063_ChIP-ChIP_OVARY_Human0.71657690
106FOXM1_23109430_ChIP-Seq_U2OS_Human0.70477205
107ELF1_17652178_ChIP-ChIP_JURKAT_Human0.68226131
108BCL6_27268052_Chip-Seq_Bcells_Human0.65914676
109EGR1_19032775_ChIP-ChIP_M12_Human0.65563897
110* RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.61798636
111IKZF1_21737484_ChIP-ChIP_HCT116_Human0.61127659

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation4.20356579
2MP0003436_decreased_susceptibility_to4.02660594
3MP0003303_peritoneal_inflammation3.60980453
4MP0009785_altered_susceptibility_to3.41082104
5MP0006082_CNS_inflammation3.30685640
6* MP0002419_abnormal_innate_immunity3.21548010
7* MP0005000_abnormal_immune_tolerance3.17695910
8MP0005671_abnormal_response_to3.13239508
9MP0005058_abnormal_lysosome_morphology3.10984233
10* MP0005025_abnormal_response_to3.01379468
11MP0002148_abnormal_hypersensitivity_rea2.98149996
12MP0001790_abnormal_immune_system2.96798618
13MP0005387_immune_system_phenotype2.96798618
14MP0000685_abnormal_immune_system2.88325935
15* MP0002452_abnormal_antigen_presenting2.80594898
16* MP0001800_abnormal_humoral_immune2.78179865
17MP0003724_increased_susceptibility_to2.73969408
18* MP0002723_abnormal_immune_serum2.64375429
19* MP0001819_abnormal_immune_cell2.56987788
20* MP0002420_abnormal_adaptive_immunity2.56965311
21MP0005464_abnormal_platelet_physiology2.39267103
22MP0002405_respiratory_system_inflammati2.31345888
23MP0004510_myositis2.25593237
24MP0003172_abnormal_lysosome_physiology2.20293450
25MP0001533_abnormal_skeleton_physiology2.15429950
26MP0009333_abnormal_splenocyte_physiolog2.02604340
27* MP0001845_abnormal_inflammatory_respons1.94699243
28* MP0000716_abnormal_immune_system1.94556711
29* MP0002398_abnormal_bone_marrow1.93225738
30MP0003191_abnormal_cellular_cholesterol1.91520936
31MP0003763_abnormal_thymus_physiology1.87234439
32* MP0004947_skin_inflammation1.81849236
33MP0003448_altered_tumor_morphology1.81067232
34MP0003300_gastrointestinal_ulcer1.80483994
35MP0001853_heart_inflammation1.79403556
36MP0010155_abnormal_intestine_physiology1.74422196
37* MP0000689_abnormal_spleen_morphology1.68311336
38MP0002006_tumorigenesis1.67124745
39MP0002166_altered_tumor_susceptibility1.66741782
40MP0009278_abnormal_bone_marrow1.66585632
41MP0000343_altered_response_to1.59517009
42* MP0002429_abnormal_blood_cell1.58519743
43* MP0002722_abnormal_immune_system1.58078151
44* MP0008469_abnormal_protein_level1.57406961
45MP0000858_altered_metastatic_potential1.56824009
46MP0005451_abnormal_body_composition1.53506241
47MP0003075_altered_response_to1.52768615
48MP0005310_abnormal_salivary_gland1.51528649
49MP0009840_abnormal_foam_cell1.47419292
50MP0000604_amyloidosis1.37747025
51MP0003183_abnormal_peptide_metabolism1.36984019
52MP0002998_abnormal_bone_remodeling1.33999555
53MP0009764_decreased_sensitivity_to1.32778366
54MP0005397_hematopoietic_system_phenotyp1.30411860
55MP0001545_abnormal_hematopoietic_system1.30411860
56MP0005166_decreased_susceptibility_to1.29781488
57MP0001873_stomach_inflammation1.28265596
58MP0000465_gastrointestinal_hemorrhage1.25432961
59MP0002396_abnormal_hematopoietic_system1.16169530
60MP0000569_abnormal_digit_pigmentation1.15276185
61MP0000703_abnormal_thymus_morphology1.11727680
62MP0003690_abnormal_glial_cell1.08544133
63* MP0002933_joint_inflammation1.08487258
64MP0005174_abnormal_tail_pigmentation1.07980835
65* MP0001851_eye_inflammation1.05633785
66MP0008004_abnormal_stomach_pH1.05467581
67MP0004808_abnormal_hematopoietic_stem1.03048513
68MP0004381_abnormal_hair_follicle1.02181184
69MP0010307_abnormal_tumor_latency1.00006431
70MP0003566_abnormal_cell_adhesion0.99285055
71MP0003866_abnormal_defecation0.98359319
72MP0005076_abnormal_cell_differentiation0.97512954
73MP0005390_skeleton_phenotype0.96871804
74MP0009763_increased_sensitivity_to0.95996938
75MP0005167_abnormal_blood-brain_barrier0.91547128
76MP0003828_pulmonary_edema0.88700159
77MP0000490_abnormal_crypts_of0.88119344
78MP0003806_abnormal_nucleotide_metabolis0.81430054
79MP0003656_abnormal_erythrocyte_physiolo0.79779590
80MP0003329_amyloid_beta_deposits0.78784304
81MP0000249_abnormal_blood_vessel0.77642223
82MP0004782_abnormal_surfactant_physiolog0.76973941
83MP0005023_abnormal_wound_healing0.75986357
84MP0009765_abnormal_xenobiotic_induced0.68318193
85MP0005164_abnormal_response_to0.67666394
86MP0001663_abnormal_digestive_system0.67238539
87* MP0003795_abnormal_bone_structure0.66977236
88MP0010352_gastrointestinal_tract_polyps0.66794626
89MP0003453_abnormal_keratinocyte_physiol0.66748755
90MP0002277_abnormal_respiratory_mucosa0.64200039
91MP0002136_abnormal_kidney_physiology0.64156804
92MP0001986_abnormal_taste_sensitivity0.63619509
93MP0008874_decreased_physiological_sensi0.62220189
94MP0008260_abnormal_autophagy0.61860642
95MP0002019_abnormal_tumor_incidence0.61786342
96MP0000015_abnormal_ear_pigmentation0.61404621
97MP0000371_diluted_coat_color0.61385076
98MP0000920_abnormal_myelination0.61072446
99MP0002132_abnormal_respiratory_system0.60992203
100MP0005075_abnormal_melanosome_morpholog0.57874189
101MP0002138_abnormal_hepatobiliary_system0.55645441
102MP0004883_abnormal_blood_vessel0.54520013
103MP0002877_abnormal_melanocyte_morpholog0.54258104
104MP0003091_abnormal_cell_migration0.53564594
105MP0008873_increased_physiological_sensi0.53457077
106MP0000609_abnormal_liver_physiology0.52632730
107MP0001958_emphysema0.52592712
108MP0004130_abnormal_muscle_cell0.52553001
109MP0003045_fibrosis0.49629618
110MP0005319_abnormal_enzyme/_coenzyme0.49552469
111MP0009115_abnormal_fat_cell0.48240105
112MP0005381_digestive/alimentary_phenotyp0.47284312
113MP0000767_abnormal_smooth_muscle0.46759591
114MP0003186_abnormal_redox_activity0.46411889

Predicted human phenotypes

RankGene SetZ-score
1Eczematoid dermatitis (HP:0000976)7.32197732
2* Recurrent abscess formation (HP:0002722)6.81727390
3Recurrent bacterial skin infections (HP:0005406)6.47173494
4Abnormality of macrophages (HP:0004311)5.13707334
5* Recurrent gram-negative bacterial infections (HP:0005420)5.03518600
6Vacuolated lymphocytes (HP:0001922)4.86995223
7Systemic lupus erythematosus (HP:0002725)4.68699388
8Mediastinal lymphadenopathy (HP:0100721)4.56930804
9Increased cerebral lipofuscin (HP:0011813)4.43136926
10Recurrent fungal infections (HP:0002841)4.40710853
11Recurrent skin infections (HP:0001581)4.30061805
12Obstructive lung disease (HP:0006536)4.26449395
13Chronic obstructive pulmonary disease (HP:0006510)4.26449395
14Myositis (HP:0100614)4.21907082
15Elevated erythrocyte sedimentation rate (HP:0003565)4.04690978
16Stomatitis (HP:0010280)3.98857220
17Increased neuronal autofluorescent lipopigment (HP:0002074)3.85203106
18Dysostosis multiplex (HP:0000943)3.72497574
19Pustule (HP:0200039)3.59254379
20Orchitis (HP:0100796)3.58263637
21Recurrent viral infections (HP:0004429)3.56061082
22Autoimmune thrombocytopenia (HP:0001973)3.51445873
23Recurrent cutaneous fungal infections (HP:0011370)3.46814209
24Chronic mucocutaneous candidiasis (HP:0002728)3.46814209
25* Gingivitis (HP:0000230)3.43269787
26Abnormality of glycolipid metabolism (HP:0010969)3.40926117
27Abnormality of liposaccharide metabolism (HP:0010968)3.40926117
28Abnormality of glycosphingolipid metabolism (HP:0004343)3.40926117
29Retrobulbar optic neuritis (HP:0100654)3.36140682
30Optic neuritis (HP:0100653)3.36140682
31Cellulitis (HP:0100658)3.18076924
32Chronic otitis media (HP:0000389)3.17706133
33Meningitis (HP:0001287)3.17465963
34Vasculitis (HP:0002633)3.01889149
35Abnormality of T cell number (HP:0011839)3.01220677
36T lymphocytopenia (HP:0005403)2.98689971
37Nasal polyposis (HP:0100582)2.98505420
38Glomerulonephritis (HP:0000099)2.92270547
39Disinhibition (HP:0000734)2.91179662
40Mucopolysacchariduria (HP:0008155)2.90463688
41Urinary glycosaminoglycan excretion (HP:0003541)2.90463688
42Interstitial pulmonary disease (HP:0006530)2.89288471
43Amyloidosis (HP:0011034)2.86818349
44Keratoconjunctivitis (HP:0001096)2.86253133
45IgM deficiency (HP:0002850)2.84107688
46Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.83864384
47Loss of speech (HP:0002371)2.80362099
48Urticaria (HP:0001025)2.76788193
49Abnormality of mucopolysaccharide metabolism (HP:0011020)2.72977108
50Abnormality of polysaccharide metabolism (HP:0011012)2.72977108
51Abnormality of glycosaminoglycan metabolism (HP:0004371)2.72977108
52Spontaneous hematomas (HP:0007420)2.71750476
53Abnormality of the nasal mucosa (HP:0000433)2.71069556
54Chest pain (HP:0100749)2.67286313
55Granulocytopenia (HP:0001913)2.64173743
56Axonal loss (HP:0003447)2.61130396
57Pulmonary infiltrates (HP:0002113)2.59085896
58Pulmonary embolism (HP:0002204)2.56327138
59Panhypogammaglobulinemia (HP:0003139)2.52622132
60Hemoptysis (HP:0002105)2.52361192
61Petechiae (HP:0000967)2.52034199
62Episodic fever (HP:0001954)2.49951087
63Increased serum ferritin (HP:0003281)2.49898281
64Abnormality of T cells (HP:0002843)2.48732834
65Purpura (HP:0000979)2.47872465
66Osteomyelitis (HP:0002754)2.47262299
67Hepatosplenomegaly (HP:0001433)2.44553949
68Recurrent bronchitis (HP:0002837)2.44236819
69Inflammation of the large intestine (HP:0002037)2.43463431
70Arterial thrombosis (HP:0004420)2.43132922
71Basal ganglia calcification (HP:0002135)2.42381555
72Recurrent pneumonia (HP:0006532)2.41328579
73Autoimmune hemolytic anemia (HP:0001890)2.36946481
74Agnosia (HP:0010524)2.35668104
75Abnormal delayed hypersensitivity skin test (HP:0002963)2.34428703
76Increased IgM level (HP:0003496)2.32391669
77Hypochromic anemia (HP:0001931)2.30682173
78Prolonged bleeding time (HP:0003010)2.30027650
79Gastrointestinal inflammation (HP:0004386)2.29505546
80Epistaxis (HP:0000421)2.26556634
81Anorexia (HP:0002039)2.26408684
82Hematochezia (HP:0002573)2.25041942
83Colitis (HP:0002583)2.25030418
84Abnormality of iron homeostasis (HP:0011031)2.23079336
85Eosinophilia (HP:0001880)2.22293067
86Gingival bleeding (HP:0000225)2.21647025
87* Leukocytosis (HP:0001974)2.18586131
88Lymphopenia (HP:0001888)2.18389243
89Prostate neoplasm (HP:0100787)2.18257373
90Myocardial infarction (HP:0001658)2.18142818
91Keratoconjunctivitis sicca (HP:0001097)2.16151293
92Mutism (HP:0002300)2.15309911
93Hypergammaglobulinemia (HP:0010702)2.15017830
94Abnormality of cells of the lymphoid lineage (HP:0012140)2.14441133
95Combined immunodeficiency (HP:0005387)2.14195484
96Cheilitis (HP:0100825)2.13878707
97Gangrene (HP:0100758)2.10231607
98Premature loss of primary teeth (HP:0006323)2.07452886
99Thoracic kyphosis (HP:0002942)2.06750877
100Recurrent lower respiratory tract infections (HP:0002783)2.05790717
101Gastrointestinal infarctions (HP:0005244)2.04044529
102Skin ulcer (HP:0200042)2.03782113
103Abnormality of T cell physiology (HP:0011840)2.03691730
104Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.02516960
105Polyneuropathy (HP:0001271)2.02409778
106Thyroiditis (HP:0100646)2.02362807
107Spondylolisthesis (HP:0003302)2.02300883
108Abnormality of eosinophils (HP:0001879)2.01535253
109Severe combined immunodeficiency (HP:0004430)2.01079194
110Abnormality of the pleura (HP:0002103)2.00378098
111Nephritis (HP:0000123)1.99987477
112Restrictive lung disease (HP:0002091)1.99775296
113Thick nail (HP:0001805)1.98149241
114Encephalitis (HP:0002383)1.97835097
115Increased CSF protein (HP:0002922)1.97725640
116Abnormality of the lumbar spine (HP:0100712)1.96875775
117Sepsis (HP:0100806)1.96760519
118Abnormality of complement system (HP:0005339)1.96661236
119Increased IgE level (HP:0003212)1.96578457
120Upper motor neuron abnormality (HP:0002127)1.95471751
121Joint swelling (HP:0001386)1.95183325
122Glomerulopathy (HP:0100820)1.93973630
123Neuronal loss in central nervous system (HP:0002529)1.89973743
124Microcytic anemia (HP:0001935)1.89688426
125Slow saccadic eye movements (HP:0000514)1.87936468

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K14.61101815
2BLK3.82989293
3TXK3.28981232
4RIPK43.26844850
5IRAK43.01689539
6TYK22.99152606
7MAP3K142.83443085
8TBK12.80844314
9PRPF4B2.60998478
10JAK32.40238822
11ZAP702.39998235
12KIT2.25161749
13IKBKE2.24849971
14STK102.18660180
15CSK2.10177076
16ERN12.08387458
17JAK11.97686601
18IRAK31.80051126
19ITK1.76623996
20HCK1.72764834
21SYK1.69603269
22TGFBR21.69497427
23FES1.68265214
24BTK1.67697264
25IKBKB1.64803153
26CSF1R1.56847980
27EPHB11.56316597
28GRK61.51723019
29TEC1.46637986
30* LCK1.43102194
31TRIB31.41592624
32FGR1.36752025
33MAP3K131.33291916
34CLK11.33256559
35FGFR41.30434443
36TAOK31.28865910
37MARK31.22915177
38LYN1.22433221
39MAP2K31.21178473
40NME21.19567186
41LRRK21.13671678
42JAK21.10754179
43TTN1.10563558
44KSR21.09748335
45FGFR31.08390630
46TAOK21.07184775
47PKN21.06287574
48RPS6KA41.04549352
49PIM10.97116482
50PBK0.93350693
51TESK20.93067230
52CAMKK20.92112038
53BMPR20.89006745
54NEK90.86407679
55TRPM70.85945538
56SIK20.84579059
57MST40.84251538
58MAP3K100.84174999
59KDR0.83981841
60MARK20.82374866
61IRAK10.79616131
62CDC42BPA0.79175272
63CHUK0.78923886
64MAP3K110.75897937
65MAPK120.75432065
66MAP3K60.75302187
67CAMK1D0.75049196
68MST1R0.74040282
69BMX0.71627735
70GRK70.71482119
71MAPK70.70151813
72PTK60.69780925
73PIM20.69121792
74PRKCQ0.69120836
75RIPK10.66613542
76PRKD20.64268214
77MOS0.61575093
78IRAK20.61249536
79ICK0.60214084
80EGFR0.59244183
81STK40.58293164
82MATK0.56733459
83MAP3K20.56432947
84MAP3K50.56123033
85FYN0.52700062
86NLK0.52694661
87CAMKK10.51729712
88ABL10.51682779
89PIK3CG0.51460529
90RET0.49442597
91PAK40.49415710
92RPS6KA20.47960111
93PDK10.47884897
94MAP3K120.47852689
95MAP3K30.47199506
96MAP2K60.47088120
97TESK10.46850737
98* PRKCD0.46393505
99RPS6KA60.46281678
100SGK30.45154263
101HIPK20.44424400
102EPHA30.43683838
103TYRO30.41038141
104CAMK1G0.40873188
105MAP3K70.40601112
106STK110.39404687
107DYRK1B0.38383696
108ABL20.38187578
109MAPKAPK20.38010925
110SMG10.37905886
111IGF1R0.37007952
112RPS6KL10.36562762
113RPS6KC10.36562762
114SIK30.35372436
115MAP2K40.34733584
116CDK120.34530777
117CDK60.34130833
118ALK0.31356768
119PDGFRB0.31248755
120TNK20.30241392
121DMPK0.29721921
122PDPK10.29211617
123MAPK40.26941501
124MAP3K80.26699579
125INSR0.26561904
126TAOK10.26333042
127CDK40.25896637
128STK240.25559479
129YES10.24028501
130MAP3K10.23974887

Predicted pathways (KEGG)

RankGene SetZ-score
1* Staphylococcus aureus infection_Homo sapiens_hsa051503.30250925
2* Leishmaniasis_Homo sapiens_hsa051403.25671530
3Graft-versus-host disease_Homo sapiens_hsa053322.79134959
4Osteoclast differentiation_Homo sapiens_hsa043802.63631265
5Other glycan degradation_Homo sapiens_hsa005112.41223330
6NF-kappa B signaling pathway_Homo sapiens_hsa040642.36753511
7Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.32675633
8Primary immunodeficiency_Homo sapiens_hsa053402.31018720
9Lysosome_Homo sapiens_hsa041422.30492272
10Toll-like receptor signaling pathway_Homo sapiens_hsa046202.29304176
11Glycosaminoglycan degradation_Homo sapiens_hsa005312.15210202
12Measles_Homo sapiens_hsa051622.14304894
13* Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.14214136
14* Tuberculosis_Homo sapiens_hsa051522.14040318
15B cell receptor signaling pathway_Homo sapiens_hsa046622.03638851
16Allograft rejection_Homo sapiens_hsa053302.02842518
17* Pertussis_Homo sapiens_hsa051332.02549013
18Intestinal immune network for IgA production_Homo sapiens_hsa046722.01700931
19Hematopoietic cell lineage_Homo sapiens_hsa046402.01408002
20Antigen processing and presentation_Homo sapiens_hsa046121.98262162
21* Legionellosis_Homo sapiens_hsa051341.89411901
22Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.79920301
23NOD-like receptor signaling pathway_Homo sapiens_hsa046211.76737903
24Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.74864907
25RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.73483336
26* Malaria_Homo sapiens_hsa051441.72014025
27T cell receptor signaling pathway_Homo sapiens_hsa046601.69029686
28Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.64026830
29Chemokine signaling pathway_Homo sapiens_hsa040621.58300802
30Salmonella infection_Homo sapiens_hsa051321.57850325
31Asthma_Homo sapiens_hsa053101.55690511
32Toxoplasmosis_Homo sapiens_hsa051451.55306381
33* Phagosome_Homo sapiens_hsa041451.55064207
34* Rheumatoid arthritis_Homo sapiens_hsa053231.52931729
35Shigellosis_Homo sapiens_hsa051311.49072522
36Influenza A_Homo sapiens_hsa051641.47986562
37TNF signaling pathway_Homo sapiens_hsa046681.43241463
38Jak-STAT signaling pathway_Homo sapiens_hsa046301.40391148
39Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.35490831
40* Leukocyte transendothelial migration_Homo sapiens_hsa046701.35097390
41Apoptosis_Homo sapiens_hsa042101.34747503
42Herpes simplex infection_Homo sapiens_hsa051681.34639188
43Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.23692546
44Hepatitis B_Homo sapiens_hsa051611.20089953
45Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.18853952
46Type I diabetes mellitus_Homo sapiens_hsa049401.18374524
47Autoimmune thyroid disease_Homo sapiens_hsa053201.05490511
48* Viral myocarditis_Homo sapiens_hsa054161.02579803
49Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.01804843
50Acute myeloid leukemia_Homo sapiens_hsa052210.98156270
51Platelet activation_Homo sapiens_hsa046110.96428728
52AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.96118173
53Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.95821638
54Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.90797755
55Pancreatic cancer_Homo sapiens_hsa052120.89935929
56Hepatitis C_Homo sapiens_hsa051600.88808125
57Caffeine metabolism_Homo sapiens_hsa002320.82663431
58African trypanosomiasis_Homo sapiens_hsa051430.81269474
59Chronic myeloid leukemia_Homo sapiens_hsa052200.80374005
60Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.78491790
61* Complement and coagulation cascades_Homo sapiens_hsa046100.76728005
62Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.76338603
63Neurotrophin signaling pathway_Homo sapiens_hsa047220.70764599
64Epstein-Barr virus infection_Homo sapiens_hsa051690.62614486
65VEGF signaling pathway_Homo sapiens_hsa043700.62283312
66Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.61940900
67* Amoebiasis_Homo sapiens_hsa051460.61280613
68Endocytosis_Homo sapiens_hsa041440.58319481
69Sphingolipid signaling pathway_Homo sapiens_hsa040710.58087729
70* Regulation of actin cytoskeleton_Homo sapiens_hsa048100.52910182
71Choline metabolism in cancer_Homo sapiens_hsa052310.51433763
72Prolactin signaling pathway_Homo sapiens_hsa049170.51017147
73Viral carcinogenesis_Homo sapiens_hsa052030.48692780
74Phosphatidylinositol signaling system_Homo sapiens_hsa040700.48199526
75Dorso-ventral axis formation_Homo sapiens_hsa043200.47932924
76GnRH signaling pathway_Homo sapiens_hsa049120.47721845
77Prion diseases_Homo sapiens_hsa050200.47026146
78Transcriptional misregulation in cancer_Homo sapiens_hsa052020.46340820
79Endometrial cancer_Homo sapiens_hsa052130.45787086
80Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.44097821
81Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.42120130
82HIF-1 signaling pathway_Homo sapiens_hsa040660.41093440
83* HTLV-I infection_Homo sapiens_hsa051660.40992261
84Glycerophospholipid metabolism_Homo sapiens_hsa005640.40442374
85mTOR signaling pathway_Homo sapiens_hsa041500.39586036
86Adipocytokine signaling pathway_Homo sapiens_hsa049200.38245698
87Bladder cancer_Homo sapiens_hsa052190.38221323
88Collecting duct acid secretion_Homo sapiens_hsa049660.37938499
89Colorectal cancer_Homo sapiens_hsa052100.35764393
90* Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.35418584
91Non-small cell lung cancer_Homo sapiens_hsa052230.33999394
92Insulin resistance_Homo sapiens_hsa049310.33336392
93Proteoglycans in cancer_Homo sapiens_hsa052050.33161968
94Sphingolipid metabolism_Homo sapiens_hsa006000.31865490
95Small cell lung cancer_Homo sapiens_hsa052220.31802914
96Carbohydrate digestion and absorption_Homo sapiens_hsa049730.31394966
97Notch signaling pathway_Homo sapiens_hsa043300.31339462
98Renal cell carcinoma_Homo sapiens_hsa052110.29106363
99SNARE interactions in vesicular transport_Homo sapiens_hsa041300.27765884
100Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.24584640
101FoxO signaling pathway_Homo sapiens_hsa040680.22521757
102Type II diabetes mellitus_Homo sapiens_hsa049300.16841272
103Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.16796221
104Pentose phosphate pathway_Homo sapiens_hsa000300.16562990
105MAPK signaling pathway_Homo sapiens_hsa040100.15819713
106Adherens junction_Homo sapiens_hsa045200.15763098
107Renin-angiotensin system_Homo sapiens_hsa046140.15052483
108Phospholipase D signaling pathway_Homo sapiens_hsa040720.14628308
109ABC transporters_Homo sapiens_hsa020100.13650409
110* Rap1 signaling pathway_Homo sapiens_hsa040150.12891813

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