ITGB3BP

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a transcriptional coregulator that binds to and enhances the activity of members of the nuclear receptor families, thyroid hormone receptors and retinoid X receptors. This protein also acts as a corepressor of NF-kappaB-dependent signaling. This protein induces apoptosis in breast cancer cells through a caspase 2-mediated signaling pathway. This protein is also a component of the centromere-specific histone H3 variant nucleosome associated complex (CENP-NAC) and may be involved in mitotic progression by recruiting the histone H3 variant CENP-A to the centromere. Alternate splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1deoxyribonucleoside monophosphate metabolic process (GO:0009162)4.37178262
2GTP biosynthetic process (GO:0006183)4.35936062
3ribosomal small subunit assembly (GO:0000028)4.31237768
4DNA deamination (GO:0045006)4.28776217
5ribosomal small subunit biogenesis (GO:0042274)4.23225605
6viral transcription (GO:0019083)4.14618860
7cotranslational protein targeting to membrane (GO:0006613)4.05399053
8DNA double-strand break processing (GO:0000729)4.04331553
9cilium or flagellum-dependent cell motility (GO:0001539)4.04260015
10SRP-dependent cotranslational protein targeting to membrane (GO:0006614)4.00489868
11DNA ligation (GO:0006266)4.00149611
12translational termination (GO:0006415)3.97135449
13protein targeting to ER (GO:0045047)3.95144079
14protein localization to kinetochore (GO:0034501)3.95117516
15central nervous system myelination (GO:0022010)3.92885893
16axon ensheathment in central nervous system (GO:0032291)3.92885893
17telomere maintenance via semi-conservative replication (GO:0032201)3.79858087
18establishment of protein localization to endoplasmic reticulum (GO:0072599)3.76314588
19protein localization to endoplasmic reticulum (GO:0070972)3.73392503
20* CENP-A containing nucleosome assembly (GO:0034080)3.70741882
21UTP biosynthetic process (GO:0006228)3.68995736
22mitochondrial respiratory chain complex I assembly (GO:0032981)3.68064114
23NADH dehydrogenase complex assembly (GO:0010257)3.68064114
24mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.68064114
25establishment of protein localization to mitochondrial membrane (GO:0090151)3.67608663
26* chromatin remodeling at centromere (GO:0031055)3.61729155
27replication fork processing (GO:0031297)3.60978285
28regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.55272402
29regulation of mitotic spindle checkpoint (GO:1903504)3.55272402
30establishment of integrated proviral latency (GO:0075713)3.54771993
31telomere maintenance via recombination (GO:0000722)3.54522085
32L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.54002999
33purine nucleobase biosynthetic process (GO:0009113)3.53489065
34protein complex biogenesis (GO:0070271)3.51842934
35ribosomal large subunit biogenesis (GO:0042273)3.49250661
36mitotic metaphase plate congression (GO:0007080)3.48710430
37kinetochore organization (GO:0051383)3.46281080
38maturation of SSU-rRNA (GO:0030490)3.45870437
39guanosine-containing compound biosynthetic process (GO:1901070)3.44435924
40mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.43694716
41mitotic sister chromatid segregation (GO:0000070)3.43628196
42regulation of DNA endoreduplication (GO:0032875)3.43434293
43DNA replication-dependent nucleosome organization (GO:0034723)3.42458535
44DNA replication-dependent nucleosome assembly (GO:0006335)3.42458535
45translational elongation (GO:0006414)3.38870544
46DNA strand elongation involved in DNA replication (GO:0006271)3.37434802
47axonemal dynein complex assembly (GO:0070286)3.37378554
48pyrimidine deoxyribonucleotide metabolic process (GO:0009219)3.35380483
49proteasome assembly (GO:0043248)3.33356198
50protein neddylation (GO:0045116)3.31452779
51protein localization to chromosome, centromeric region (GO:0071459)3.30708700
52negative regulation of DNA-dependent DNA replication (GO:2000104)3.30543129
53sister chromatid segregation (GO:0000819)3.30521492
54nucleotide-excision repair, DNA gap filling (GO:0006297)3.29187009
55cilium movement (GO:0003341)3.29061994
56DNA strand elongation (GO:0022616)3.28528186
57mitochondrial respiratory chain complex assembly (GO:0033108)3.28519062
58mitotic recombination (GO:0006312)3.28373231
59epithelial cilium movement (GO:0003351)3.27113415
60establishment of viral latency (GO:0019043)3.26602106
61metaphase plate congression (GO:0051310)3.26428245
62mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.24950690
63regulation of centriole replication (GO:0046599)3.24747196
64kinetochore assembly (GO:0051382)3.24109508
65DNA catabolic process, exonucleolytic (GO:0000738)3.23592589
66spindle checkpoint (GO:0031577)3.21941433
67peptidyl-histidine modification (GO:0018202)3.21655603
68pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.20769835
69mismatch repair (GO:0006298)3.19530881
70viral life cycle (GO:0019058)3.18229091
71negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.17443649
72pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)3.17221220
73nucleobase biosynthetic process (GO:0046112)3.16838744
74negative regulation of sister chromatid segregation (GO:0033046)3.16817719
75negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.16817719
76negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.16817719
77negative regulation of mitotic sister chromatid segregation (GO:0033048)3.16817719
78negative regulation of mitotic sister chromatid separation (GO:2000816)3.16817719
79GPI anchor biosynthetic process (GO:0006506)3.16190557
80energy coupled proton transport, down electrochemical gradient (GO:0015985)3.15101711
81ATP synthesis coupled proton transport (GO:0015986)3.15101711
82deoxyribonucleoside triphosphate metabolic process (GO:0009200)3.14873262
83preassembly of GPI anchor in ER membrane (GO:0016254)3.13392039
84regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.13124929
85nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.12830532
86cellular protein complex disassembly (GO:0043624)3.12816317
87negative regulation of chromosome segregation (GO:0051985)3.12631352
88UTP metabolic process (GO:0046051)3.12380688
89CTP metabolic process (GO:0046036)3.12203769
90CTP biosynthetic process (GO:0006241)3.12203769
91recombinational repair (GO:0000725)3.11932473
92double-strand break repair via homologous recombination (GO:0000724)3.10426283
93exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.09722057
94mitotic spindle checkpoint (GO:0071174)3.09676525
95mitotic G2/M transition checkpoint (GO:0044818)3.08837804
96telomere maintenance via telomere lengthening (GO:0010833)3.08739334
97anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.08148023
98respiratory electron transport chain (GO:0022904)3.08131882
99postreplication repair (GO:0006301)3.07490121
100non-recombinational repair (GO:0000726)3.07237947
101double-strand break repair via nonhomologous end joining (GO:0006303)3.07237947
102meiotic chromosome segregation (GO:0045132)3.06392541
103intraciliary transport (GO:0042073)3.05713666
104termination of RNA polymerase III transcription (GO:0006386)3.05310693
105transcription elongation from RNA polymerase III promoter (GO:0006385)3.05310693
106deoxyribonucleotide biosynthetic process (GO:0009263)3.04993155
107maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.04945371
108* histone exchange (GO:0043486)3.04886015
109RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.02907098
110tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.02907098
111synapsis (GO:0007129)3.02869187
112electron transport chain (GO:0022900)3.02727143
113DNA replication initiation (GO:0006270)3.02691542
114pyrimidine nucleoside triphosphate metabolic process (GO:0009147)3.01001615
115chaperone-mediated protein transport (GO:0072321)2.99558744
116transcription-coupled nucleotide-excision repair (GO:0006283)2.99223177
117spindle assembly checkpoint (GO:0071173)2.96238857
118mitotic spindle assembly checkpoint (GO:0007094)2.95867976
119translation (GO:0006412)2.94757111
120regulation of mitotic metaphase/anaphase transition (GO:0030071)2.94723755
121regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.94723755
122nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.94321414
123histone mRNA metabolic process (GO:0008334)2.92200049
124protein K6-linked ubiquitination (GO:0085020)2.91994528
125IMP biosynthetic process (GO:0006188)2.91568997
126RNA capping (GO:0036260)2.91537431
1277-methylguanosine RNA capping (GO:0009452)2.91537431
128centriole replication (GO:0007099)2.91323848
129regulation of mitotic sister chromatid separation (GO:0010965)2.91214874
130regulation of mitotic sister chromatid segregation (GO:0033047)2.91214874
131regulation of sister chromatid segregation (GO:0033045)2.91214874
132translesion synthesis (GO:0019985)2.89419784
133rRNA modification (GO:0000154)2.88331199
134positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.88108185
135viral mRNA export from host cell nucleus (GO:0046784)2.87763745
136* chromatin assembly or disassembly (GO:0006333)2.85968152
137mannosylation (GO:0097502)2.85091207
138centriole assembly (GO:0098534)2.85013738
139regulation of mitochondrial translation (GO:0070129)2.84831831
140regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.84411937
141signal peptide processing (GO:0006465)2.82855370
142GPI anchor metabolic process (GO:0006505)2.81738328
1437-methylguanosine mRNA capping (GO:0006370)2.81254171
144spliceosomal complex assembly (GO:0000245)2.77051643
145translational initiation (GO:0006413)2.76476945
146epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.75615668
147DNA replication checkpoint (GO:0000076)2.75246672
148respiratory chain complex IV assembly (GO:0008535)2.75058773
149* DNA replication-independent nucleosome organization (GO:0034724)2.74469634
150* DNA replication-independent nucleosome assembly (GO:0006336)2.74469634
151spermatid nucleus differentiation (GO:0007289)2.73655373
152limb bud formation (GO:0060174)2.72046144
153pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)2.71363017
154deoxyribose phosphate biosynthetic process (GO:0046385)2.69694166
1552-deoxyribonucleotide biosynthetic process (GO:0009265)2.69694166
156protein complex disassembly (GO:0043241)2.68153168
157microtubule depolymerization (GO:0007019)2.67232852

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human4.39226313
2* KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.32985813
3SOX9_22984422_ChIP-ChIP_TESTIS_Rat4.13403929
4CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human3.70632076
5* GABP_17652178_ChIP-ChIP_JURKAT_Human3.59534288
6EST1_17652178_ChIP-ChIP_JURKAT_Human3.47169427
7MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse3.12846284
8* JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.04736426
9ELF1_17652178_ChIP-ChIP_JURKAT_Human3.01963817
10HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.92386836
11HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.87213905
12MYC_18555785_ChIP-Seq_MESCs_Mouse2.82804948
13CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.77252678
14* E2F4_17652178_ChIP-ChIP_JURKAT_Human2.74894930
15HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.70574343
16NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.58655485
17FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.53833897
18ETS1_20019798_ChIP-Seq_JURKAT_Human2.47539115
19CREB1_15753290_ChIP-ChIP_HEK293T_Human2.37009677
20ELK1_19687146_ChIP-ChIP_HELA_Human2.20949365
21VDR_23849224_ChIP-Seq_CD4+_Human2.17363619
22E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.15167178
23SRF_21415370_ChIP-Seq_HL-1_Mouse2.13493955
24* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.13027817
25PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.04888339
26E2F1_21310950_ChIP-Seq_MCF-7_Human1.95896466
27* FOXP3_21729870_ChIP-Seq_TREG_Human1.93744986
28FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.91589196
29MYC_19030024_ChIP-ChIP_MESCs_Mouse1.90280310
30SALL1_21062744_ChIP-ChIP_HESCs_Human1.90256943
31VDR_22108803_ChIP-Seq_LS180_Human1.90094066
32RBPJ_22232070_ChIP-Seq_NCS_Mouse1.90078663
33MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.88775753
34* MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.85306066
35TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.81236839
36DCP1A_22483619_ChIP-Seq_HELA_Human1.79703096
37THAP11_20581084_ChIP-Seq_MESCs_Mouse1.68138935
38TTF2_22483619_ChIP-Seq_HELA_Human1.66873672
39XRN2_22483619_ChIP-Seq_HELA_Human1.66451438
40E2F1_18555785_ChIP-Seq_MESCs_Mouse1.65005061
41MYC_19079543_ChIP-ChIP_MESCs_Mouse1.64845672
42KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.64174241
43PCGF2_27294783_Chip-Seq_ESCs_Mouse1.62159425
44ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.59779273
45HOXB4_20404135_ChIP-ChIP_EML_Mouse1.52585751
46FOXM1_23109430_ChIP-Seq_U2OS_Human1.50235777
47FLI1_27457419_Chip-Seq_LIVER_Mouse1.48757443
48MYC_18940864_ChIP-ChIP_HL60_Human1.47041541
49FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.46778427
50YY1_21170310_ChIP-Seq_MESCs_Mouse1.42662360
51TAF15_26573619_Chip-Seq_HEK293_Human1.42116887
52FUS_26573619_Chip-Seq_HEK293_Human1.40094841
53IRF1_19129219_ChIP-ChIP_H3396_Human1.39924897
54DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.39483812
55ERG_20887958_ChIP-Seq_HPC-7_Mouse1.39466877
56NELFA_20434984_ChIP-Seq_ESCs_Mouse1.38954241
57POU5F1_16153702_ChIP-ChIP_HESCs_Human1.36380702
58ZNF274_21170338_ChIP-Seq_K562_Hela1.36127288
59ZFP57_27257070_Chip-Seq_ESCs_Mouse1.30953504
60ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.30067687
61YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.29557419
62SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.29440059
63GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.27758262
64EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.24992889
65BMI1_23680149_ChIP-Seq_NPCS_Mouse1.22091420
66TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.21705688
67* EWS_26573619_Chip-Seq_HEK293_Human1.21625755
68FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.20550867
69NANOG_16153702_ChIP-ChIP_HESCs_Human1.19928133
70* GABP_19822575_ChIP-Seq_HepG2_Human1.19813480
71* POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.18060645
72PCGF2_27294783_Chip-Seq_NPCs_Mouse1.15079565
73PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.14480284
74AR_21909140_ChIP-Seq_LNCAP_Human1.13854821
75CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.11487059
76PADI4_21655091_ChIP-ChIP_MCF-7_Human1.11356953
77* POU3F2_20337985_ChIP-ChIP_501MEL_Human1.10956839
78* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.09314560
79NFE2_27457419_Chip-Seq_LIVER_Mouse1.08587766
80TAL1_26923725_Chip-Seq_HPCs_Mouse1.07137477
81ELK1_22589737_ChIP-Seq_MCF10A_Human1.05966865
82CBX2_27304074_Chip-Seq_ESCs_Mouse1.04985229
83TP63_19390658_ChIP-ChIP_HaCaT_Human1.02366320
84* RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.01846605
85NOTCH1_21737748_ChIP-Seq_TLL_Human1.01204367
86* P300_19829295_ChIP-Seq_ESCs_Human1.00816672
87EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.98911601
88* MYCN_18555785_ChIP-Seq_MESCs_Mouse0.98883969
89SUZ12_27294783_Chip-Seq_NPCs_Mouse0.97787465
90EZH2_27294783_Chip-Seq_NPCs_Mouse0.97731373
91SOX2_16153702_ChIP-ChIP_HESCs_Human0.97688219
92SUZ12_18555785_Chip-Seq_ESCs_Mouse0.95635390
93* POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.95138827
94MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.94842994
95* IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.94673731
96KDM5A_27292631_Chip-Seq_BREAST_Human0.93958426
97SOX2_18555785_ChIP-Seq_MESCs_Mouse0.93409648
98P300_18555785_Chip-Seq_ESCs_Mouse0.93240271
99PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.92859128
100STAT3_18555785_Chip-Seq_ESCs_Mouse0.92672734
101CTBP2_25329375_ChIP-Seq_LNCAP_Human0.92589302
102RNF2_27304074_Chip-Seq_NSC_Mouse0.92282206
103P53_22387025_ChIP-Seq_ESCs_Mouse0.92128652
104EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.91709978
105SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.91674319
106EZH2_22144423_ChIP-Seq_EOC_Human0.89378161
107LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.88994084
108CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.88877620
109NANOG_18555785_Chip-Seq_ESCs_Mouse0.88553422
110EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.88461775
111CTBP1_25329375_ChIP-Seq_LNCAP_Human0.88363194
112NMYC_18555785_Chip-Seq_ESCs_Mouse0.87123597
113OCT4_18555785_Chip-Seq_ESCs_Mouse0.85608079
114ZFX_18555785_Chip-Seq_ESCs_Mouse0.85515682
115TP53_22573176_ChIP-Seq_HFKS_Human0.84925763
116IGF1R_20145208_ChIP-Seq_DFB_Human0.84515282
117KLF4_18555785_Chip-Seq_ESCs_Mouse0.84465968
118PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.83916334
119GBX2_23144817_ChIP-Seq_PC3_Human0.83310111
120* HTT_18923047_ChIP-ChIP_STHdh_Human0.81160664
121GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.79588384
122* CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.78272752
123SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.76395869
124* HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.74824363
125FOXA1_27270436_Chip-Seq_PROSTATE_Human0.73273207
126FOXA1_25329375_ChIP-Seq_VCAP_Human0.73273207
127UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.73230699
128NANOG_19829295_ChIP-Seq_ESCs_Human0.73186087

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000566_synostosis3.61000288
2MP0003136_yellow_coat_color3.55108373
3MP0006292_abnormal_olfactory_placode3.11534119
4MP0009379_abnormal_foot_pigmentation3.03075281
5MP0008058_abnormal_DNA_repair2.82217355
6MP0005410_abnormal_fertilization2.82166491
7MP0004147_increased_porphyrin_level2.77081716
8MP0010094_abnormal_chromosome_stability2.72923389
9MP0001188_hyperpigmentation2.54024171
10MP0001986_abnormal_taste_sensitivity2.49688660
11MP0002102_abnormal_ear_morphology2.45919902
12MP0008057_abnormal_DNA_replication2.43267866
13MP0004381_abnormal_hair_follicle2.35240527
14MP0001529_abnormal_vocalization2.21334945
15MP0002638_abnormal_pupillary_reflex2.10337078
16MP0003693_abnormal_embryo_hatching2.04886383
17MP0008877_abnormal_DNA_methylation1.93398139
18MP0005409_darkened_coat_color1.92989401
19MP0006072_abnormal_retinal_apoptosis1.90577243
20MP0000372_irregular_coat_pigmentation1.89248273
21MP0002132_abnormal_respiratory_system1.79205827
22MP0002938_white_spotting1.78319904
23MP0003890_abnormal_embryonic-extraembry1.72376963
24MP0008007_abnormal_cellular_replicative1.71140797
25MP0008932_abnormal_embryonic_tissue1.66086047
26MP0001929_abnormal_gametogenesis1.58686912
27MP0003077_abnormal_cell_cycle1.55642949
28MP0003786_premature_aging1.54321206
29MP0002210_abnormal_sex_determination1.50741458
30MP0000049_abnormal_middle_ear1.50695758
31MP0001905_abnormal_dopamine_level1.50678057
32MP0004133_heterotaxia1.50433422
33MP0005171_absent_coat_pigmentation1.48992832
34MP0002736_abnormal_nociception_after1.48147801
35MP0006035_abnormal_mitochondrial_morpho1.44696230
36MP0004957_abnormal_blastocyst_morpholog1.42779564
37MP0003698_abnormal_male_reproductive1.42533673
38MP0003111_abnormal_nucleus_morphology1.42025445
39MP0005379_endocrine/exocrine_gland_phen1.41133461
40MP0005253_abnormal_eye_physiology1.35812493
41MP0002095_abnormal_skin_pigmentation1.34819765
42MP0000631_abnormal_neuroendocrine_gland1.33781507
43MP0005646_abnormal_pituitary_gland1.32963850
44MP0002277_abnormal_respiratory_mucosa1.32131560
45MP0002396_abnormal_hematopoietic_system1.29881456
46MP0003938_abnormal_ear_development1.29022252
47MP0000613_abnormal_salivary_gland1.25831316
48MP0003941_abnormal_skin_development1.24181026
49MP0005551_abnormal_eye_electrophysiolog1.23928229
50MP0000920_abnormal_myelination1.22574227
51MP0001697_abnormal_embryo_size1.21244496
52MP0000026_abnormal_inner_ear1.20041877
53MP0001145_abnormal_male_reproductive1.19266144
54MP0005174_abnormal_tail_pigmentation1.19259668
55MP0005084_abnormal_gallbladder_morpholo1.18720347
56MP0002160_abnormal_reproductive_system1.18088532
57MP0004142_abnormal_muscle_tone1.16994510
58MP0009697_abnormal_copulation1.16226160
59MP0003567_abnormal_fetal_cardiomyocyte1.15496894
60MP0001485_abnormal_pinna_reflex1.15180041
61MP0005075_abnormal_melanosome_morpholog1.15118179
62MP0010030_abnormal_orbit_morphology1.13844777
63MP0000350_abnormal_cell_proliferation1.12650043
64MP0002163_abnormal_gland_morphology1.12613375
65MP0003806_abnormal_nucleotide_metabolis1.12311606
66MP0003119_abnormal_digestive_system1.12037362
67MP0008995_early_reproductive_senescence1.11549187
68MP0001293_anophthalmia1.07977170
69MP0000653_abnormal_sex_gland1.07769373
70MP0003315_abnormal_perineum_morphology1.06319217
71MP0003763_abnormal_thymus_physiology1.05635664
72MP0008872_abnormal_physiological_respon1.04188503
73MP0008789_abnormal_olfactory_epithelium1.03150694
74MP0002084_abnormal_developmental_patter1.01967789
75MP0000383_abnormal_hair_follicle1.00924692
76MP0003195_calcinosis1.00621967
77MP0003950_abnormal_plasma_membrane1.00205817
78MP0003121_genomic_imprinting0.99444370
79MP0002837_dystrophic_cardiac_calcinosis0.99044727
80MP0001730_embryonic_growth_arrest0.98882413
81MP0002697_abnormal_eye_size0.98189702
82MP0003011_delayed_dark_adaptation0.97803269
83MP0003186_abnormal_redox_activity0.97321195
84MP0004215_abnormal_myocardial_fiber0.97249616
85MP0010307_abnormal_tumor_latency0.96445143
86MP0000015_abnormal_ear_pigmentation0.96113191
87MP0002751_abnormal_autonomic_nervous0.96081497
88MP0002234_abnormal_pharynx_morphology0.95905815
89MP0005391_vision/eye_phenotype0.95401885
90MP0001764_abnormal_homeostasis0.95124816
91MP0004742_abnormal_vestibular_system0.95040978
92MP0002085_abnormal_embryonic_tissue0.94908308
93MP0000358_abnormal_cell_content/0.94711396
94MP0003937_abnormal_limbs/digits/tail_de0.93500483
95MP0005394_taste/olfaction_phenotype0.93238674
96MP0005499_abnormal_olfactory_system0.93238674
97MP0005380_embryogenesis_phenotype0.92707219
98MP0001672_abnormal_embryogenesis/_devel0.92707219
99MP0010386_abnormal_urinary_bladder0.91828617
100MP0001727_abnormal_embryo_implantation0.89225825
101MP0000678_abnormal_parathyroid_gland0.88810243
102MP0000462_abnormal_digestive_system0.86499761
103MP0005389_reproductive_system_phenotype0.86368059
104MP0006276_abnormal_autonomic_nervous0.85938208
105MP0005423_abnormal_somatic_nervous0.85225385
106MP0005671_abnormal_response_to0.85203401
107MP0002177_abnormal_outer_ear0.84023350
108MP0001984_abnormal_olfaction0.83570990
109MP0003718_maternal_effect0.81570505
110MP0005395_other_phenotype0.79738403
111MP0006036_abnormal_mitochondrial_physio0.78377241
112MP0005645_abnormal_hypothalamus_physiol0.76178148
113MP0001968_abnormal_touch/_nociception0.75288327
114MP0002080_prenatal_lethality0.74839145
115MP0002111_abnormal_tail_morphology0.73440546
116MP0001963_abnormal_hearing_physiology0.72782070
117MP0001919_abnormal_reproductive_system0.72595577
118MP0003984_embryonic_growth_retardation0.70047389
119MP0003699_abnormal_female_reproductive0.69657168
120MP0002752_abnormal_somatic_nervous0.69158981
121MP0002019_abnormal_tumor_incidence0.68986217
122MP0005408_hypopigmentation0.68986159
123MP0005195_abnormal_posterior_eye0.68915774
124MP0001324_abnormal_eye_pigmentation0.68669739
125MP0002161_abnormal_fertility/fecundity0.68653038
126MP0000313_abnormal_cell_death0.68472878
127MP0002249_abnormal_larynx_morphology0.68465804
128MP0002088_abnormal_embryonic_growth/wei0.68241420
129MP0001286_abnormal_eye_development0.68024076
130MP0005464_abnormal_platelet_physiology0.67775603
131MP0000490_abnormal_crypts_of0.66747086
132MP0000762_abnormal_tongue_morphology0.64586956
133MP0002148_abnormal_hypersensitivity_rea0.64424287
134MP0001119_abnormal_female_reproductive0.63038258
135MP0002233_abnormal_nose_morphology0.62021766
136MP0004043_abnormal_pH_regulation0.61093508
137MP0001346_abnormal_lacrimal_gland0.60535632
138MP0000647_abnormal_sebaceous_gland0.59922340

Predicted human phenotypes

RankGene SetZ-score
1Respiratory insufficiency due to defective ciliary clearance (HP:0200073)4.21906651
2Acute necrotizing encephalopathy (HP:0006965)3.89467453
3Reticulocytopenia (HP:0001896)3.72949718
4Abnormal ciliary motility (HP:0012262)3.71948749
5Abnormal respiratory epithelium morphology (HP:0012253)3.61340859
6Abnormal respiratory motile cilium morphology (HP:0005938)3.61340859
7Dynein arm defect of respiratory motile cilia (HP:0012255)3.61324893
8Absent/shortened dynein arms (HP:0200106)3.61324893
9Mitochondrial inheritance (HP:0001427)3.58625410
10Abnormal respiratory motile cilium physiology (HP:0012261)3.57321812
11Abnormal mitochondria in muscle tissue (HP:0008316)3.43340269
12Hepatocellular necrosis (HP:0001404)3.33749874
13Progressive macrocephaly (HP:0004481)3.20420222
14Increased hepatocellular lipid droplets (HP:0006565)3.14785941
15Abnormality of cells of the erythroid lineage (HP:0012130)3.06383230
16Type I transferrin isoform profile (HP:0003642)3.03543024
17Abnormal number of erythroid precursors (HP:0012131)2.98201656
18Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.97327610
19Decreased activity of mitochondrial respiratory chain (HP:0008972)2.97327610
20Increased CSF lactate (HP:0002490)2.95027246
21Renal Fanconi syndrome (HP:0001994)2.92976218
22Hepatic necrosis (HP:0002605)2.90080995
23Medial flaring of the eyebrow (HP:0010747)2.87967767
24Acute encephalopathy (HP:0006846)2.81271498
25Small intestinal stenosis (HP:0012848)2.75963653
26Duodenal stenosis (HP:0100867)2.75963653
27Abnormality of the renal collecting system (HP:0004742)2.75648060
28Duplicated collecting system (HP:0000081)2.74050808
29True hermaphroditism (HP:0010459)2.73777095
30Abnormality of the labia minora (HP:0012880)2.71583540
31Macrocytic anemia (HP:0001972)2.71290667
32Chromsome breakage (HP:0040012)2.71256098
33Colon cancer (HP:0003003)2.69266826
34Cerebral edema (HP:0002181)2.61413533
35Lipid accumulation in hepatocytes (HP:0006561)2.60915853
36Septo-optic dysplasia (HP:0100842)2.55178345
37Chromosomal breakage induced by crosslinking agents (HP:0003221)2.55152886
38Hypothermia (HP:0002045)2.53160322
39Microvesicular hepatic steatosis (HP:0001414)2.52673462
40Nephronophthisis (HP:0000090)2.48496483
41Abnormality of the duodenum (HP:0002246)2.45304573
42Aplasia/Hypoplasia of the sacrum (HP:0008517)2.44998273
43Rhinitis (HP:0012384)2.43066511
44Molar tooth sign on MRI (HP:0002419)2.41743882
45Abnormality of midbrain morphology (HP:0002418)2.41743882
46Pancreatic cysts (HP:0001737)2.41032207
47Optic disc pallor (HP:0000543)2.40543362
48Pallor (HP:0000980)2.40210105
4911 pairs of ribs (HP:0000878)2.38745135
50Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.38393734
51Abnormality of the septum pellucidum (HP:0007375)2.37314632
52Pancreatic fibrosis (HP:0100732)2.36310014
53Asplenia (HP:0001746)2.34147081
54Volvulus (HP:0002580)2.31933754
55Sloping forehead (HP:0000340)2.31427255
56Congenital, generalized hypertrichosis (HP:0004540)2.31235600
57Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.30772519
58Ectopic kidney (HP:0000086)2.30413262
59Abnormality of glycolysis (HP:0004366)2.29941976
60Increased serum pyruvate (HP:0003542)2.29941976
61Exertional dyspnea (HP:0002875)2.28587421
62Abnormality of renal resorption (HP:0011038)2.28084800
633-Methylglutaconic aciduria (HP:0003535)2.27778336
64Abnormality of the preputium (HP:0100587)2.26091704
65Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.25892295
66Abnormal protein glycosylation (HP:0012346)2.24451985
67Abnormal glycosylation (HP:0012345)2.24451985
68Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.24451985
69Abnormal protein N-linked glycosylation (HP:0012347)2.24451985
70Exercise intolerance (HP:0003546)2.24023068
71Increased serum lactate (HP:0002151)2.23619118
72Absent septum pellucidum (HP:0001331)2.22961114
73Congenital primary aphakia (HP:0007707)2.22832386
74Absent thumb (HP:0009777)2.21033626
75Clubbing of toes (HP:0100760)2.19242308
76Hyperglycinemia (HP:0002154)2.18242721
77Myelodysplasia (HP:0002863)2.17963121
78Hypoplasia of the pons (HP:0012110)2.15895119
79Patchy hypopigmentation of hair (HP:0011365)2.14705216
80Methylmalonic acidemia (HP:0002912)2.14458871
81Leukodystrophy (HP:0002415)2.14337556
82Median cleft lip (HP:0000161)2.13495662
83Aplasia/Hypoplasia of the spleen (HP:0010451)2.12847029
84Partial duplication of thumb phalanx (HP:0009944)2.12538297
85Abnormal lung lobation (HP:0002101)2.12051211
86Abnormality of the pons (HP:0007361)2.10907128
87Aplasia/hypoplasia of the uterus (HP:0008684)2.10338620
88Duplication of thumb phalanx (HP:0009942)2.08913704
89Abnormality of alanine metabolism (HP:0010916)2.08196688
90Hyperalaninemia (HP:0003348)2.08196688
91Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.08196688
92Tubulointerstitial nephritis (HP:0001970)2.07016874
93Gait imbalance (HP:0002141)2.06931786
94Nephrogenic diabetes insipidus (HP:0009806)2.06867272
95Sclerocornea (HP:0000647)2.04546342
96Preaxial hand polydactyly (HP:0001177)2.04513166
97Triphalangeal thumb (HP:0001199)2.04403729
98Abnormality of the renal medulla (HP:0100957)2.02079669
99Birth length less than 3rd percentile (HP:0003561)1.99530153
100Genital tract atresia (HP:0001827)1.98532670
101Pancytopenia (HP:0001876)1.98292005
102Vaginal atresia (HP:0000148)1.95837712
103Abnormal number of incisors (HP:0011064)1.92789531
104Optic nerve hypoplasia (HP:0000609)1.92678550
105Abnormality of chromosome stability (HP:0003220)1.91785978
106Anencephaly (HP:0002323)1.90618177
107Respiratory failure (HP:0002878)1.90174182
108Aplasia/Hypoplasia of the uvula (HP:0010293)1.90105638
109Postaxial foot polydactyly (HP:0001830)1.89714775
110Abnormality of methionine metabolism (HP:0010901)1.89604599
111Male pseudohermaphroditism (HP:0000037)1.88148852
112Meckel diverticulum (HP:0002245)1.88111768
113Bronchiectasis (HP:0002110)1.86765640
114Respiratory difficulties (HP:0002880)1.86494151
115Lactic acidosis (HP:0003128)1.85757526
116Absent rod-and cone-mediated responses on ERG (HP:0007688)1.85398073
117Increased intramyocellular lipid droplets (HP:0012240)1.85149938
118Abnormality of serum amino acid levels (HP:0003112)1.84458208
119Cerebral hypomyelination (HP:0006808)1.83755661
120Nephroblastoma (Wilms tumor) (HP:0002667)1.83744543
121Supernumerary spleens (HP:0009799)1.82824472
122Renal cortical cysts (HP:0000803)1.82786999
123Neoplasm of the colon (HP:0100273)1.82251938
124Abnormality of the renal cortex (HP:0011035)1.81042327
125Abnormality of the carotid arteries (HP:0005344)1.80246064
126Abnormality of the ileum (HP:0001549)1.80007462
127Attenuation of retinal blood vessels (HP:0007843)1.79423754
128Parakeratosis (HP:0001036)1.79346172
129Aplastic anemia (HP:0001915)1.78734388
130Oral leukoplakia (HP:0002745)1.78714366
131Absent radius (HP:0003974)1.78309483
132Embryonal renal neoplasm (HP:0011794)1.78065495
133Partial duplication of the phalanx of hand (HP:0009999)1.76545653
134Intestinal atresia (HP:0011100)1.76347834
135Megaloblastic anemia (HP:0001889)1.74312970
136Degeneration of anterior horn cells (HP:0002398)1.73272812
137Abnormality of the anterior horn cell (HP:0006802)1.73272812
138Absent forearm bone (HP:0003953)1.71664103
139Aplasia involving forearm bones (HP:0009822)1.71664103
140Methylmalonic aciduria (HP:0012120)1.70879069
141Bifid tongue (HP:0010297)1.70718324
142Pancreatic islet-cell hyperplasia (HP:0004510)1.70431772
143Horseshoe kidney (HP:0000085)1.68061094
144Dyschromatopsia (HP:0007641)1.67288786

Predicted kinase interactions (KEA)

RankGene SetZ-score
1STK163.91299829
2BUB13.41430623
3PBK3.13294497
4VRK22.98214504
5VRK12.73538421
6STK392.39255686
7CDC72.26883974
8TLK12.24226548
9WEE12.21690135
10NUAK12.18370782
11NME22.16198160
12NEK12.07695081
13SRPK12.04987772
14TNIK2.04254620
15MST42.02441382
16MKNK11.98403314
17FRK1.85151322
18EIF2AK31.74322411
19EIF2AK11.73554213
20WNK31.64287638
21DYRK31.63619194
22BCR1.63384684
23MAPKAPK51.59628845
24TRIM281.59450705
25CCNB11.59126816
26MAPK151.58286233
27PASK1.57900548
28CASK1.55822381
29BRSK21.45266138
30MKNK21.42474649
31BMPR1B1.36979735
32MAP4K21.34304477
33TAF11.31199527
34OXSR11.30927654
35GRK11.26717386
36TEC1.26545965
37PLK41.26310559
38ZAK1.25226500
39EIF2AK21.23538382
40BLK1.23373954
41ADRBK21.20279708
42NME11.19655549
43TTK1.18799054
44NEK61.17379968
45YES11.16964843
46BRAF1.16635551
47STK31.15181180
48PLK21.11400079
49CLK11.07352970
50RPS6KA51.06034307
51IRAK41.04796370
52PLK11.01992489
53CDK81.01857151
54CDK31.00289010
55MUSK0.97765895
56PDK20.96035492
57AURKB0.95596916
58ACVR1B0.94010665
59WNK40.93583500
60AURKA0.93483157
61DYRK20.92847811
62ATR0.92242956
63TXK0.92207363
64IRAK10.89623127
65INSRR0.88751203
66IRAK30.84418210
67SIK30.84131663
68ERBB30.83567938
69PLK30.83553006
70IRAK20.83171419
71GRK70.82622851
72PKN10.82511992
73PIM20.79196395
74CDK70.77542888
75CDK190.75445210
76TGFBR10.74025496
77BTK0.71820690
78CHEK20.71388225
79KIT0.70096665
80BCKDK0.69426698
81TESK20.69393789
82BMPR20.67935017
83UHMK10.66837643
84NEK20.66828058
85NLK0.66241148
86PNCK0.66196699
87CSNK2A10.65669997
88RPS6KA40.65408709
89STK40.64019663
90OBSCN0.59814392
91CSNK1G30.58359850
92BRSK10.57632860
93STK38L0.56527959
94STK240.56239433
95PIK3CG0.51950676
96TSSK60.51904228
97TRPM70.50444270
98CSNK1G10.49004001
99CSNK2A20.48391417
100CHEK10.47684236
101ARAF0.46895491
102LYN0.46446636
103MYLK0.45469676
104TAOK30.44318832
105CSNK1G20.44254685
106CSNK1A1L0.42187526
107BRD40.42055898
108ATM0.41755039
109ITK0.41179793
110CAMK2B0.40961419
111MAP2K70.39105378
112RPS6KB20.37815231
113LATS10.37554311
114* CDK20.36406490
115CSNK1E0.35574472
116SGK4940.35204914
117SGK2230.35204914
118PRKCG0.33838355
119MAPK130.33591165
120CDK10.33240529
121MAP3K40.32539054
122ADRBK10.31938462
123PIM10.31046868
124BMX0.29755947
125CAMK2D0.28865173
126FLT30.28807699
127ILK0.25613630
128PRKDC0.25027132
129MELK0.24501804
130PRKACB0.24174200
131FGFR10.24142278
132KDR0.23919173
133FGFR20.22806024
134CSNK1A10.21826737

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030104.20999483
2Protein export_Homo sapiens_hsa030603.64480108
3DNA replication_Homo sapiens_hsa030303.57452505
4Mismatch repair_Homo sapiens_hsa034303.42411928
5Homologous recombination_Homo sapiens_hsa034403.27757431
6RNA polymerase_Homo sapiens_hsa030202.95943911
7Oxidative phosphorylation_Homo sapiens_hsa001902.90369398
8Proteasome_Homo sapiens_hsa030502.87629153
9Fanconi anemia pathway_Homo sapiens_hsa034602.52078292
10Parkinsons disease_Homo sapiens_hsa050122.51343173
11Nucleotide excision repair_Homo sapiens_hsa034202.50313441
12Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.41897436
13Base excision repair_Homo sapiens_hsa034102.41853834
14Spliceosome_Homo sapiens_hsa030402.39160949
15Basal transcription factors_Homo sapiens_hsa030222.33958767
16Non-homologous end-joining_Homo sapiens_hsa034502.32399551
17Pyrimidine metabolism_Homo sapiens_hsa002402.31578429
18Huntingtons disease_Homo sapiens_hsa050162.18532632
19Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.91816741
20Alzheimers disease_Homo sapiens_hsa050101.78107214
21Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.58418008
22Purine metabolism_Homo sapiens_hsa002301.57993224
23RNA degradation_Homo sapiens_hsa030181.57579377
24Cell cycle_Homo sapiens_hsa041101.48074277
25Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.44896042
26RNA transport_Homo sapiens_hsa030131.39457605
27Fatty acid elongation_Homo sapiens_hsa000621.35667068
28Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.29210977
29Arachidonic acid metabolism_Homo sapiens_hsa005901.21169901
30One carbon pool by folate_Homo sapiens_hsa006701.17942836
31Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.16950061
32Phototransduction_Homo sapiens_hsa047441.16931497
33Ether lipid metabolism_Homo sapiens_hsa005651.13662220
34Sulfur metabolism_Homo sapiens_hsa009201.11306339
35Linoleic acid metabolism_Homo sapiens_hsa005911.10195141
36Nitrogen metabolism_Homo sapiens_hsa009101.01259967
37Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.98521573
38Systemic lupus erythematosus_Homo sapiens_hsa053220.95766534
39Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.93677689
40Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.93565140
41SNARE interactions in vesicular transport_Homo sapiens_hsa041300.90374445
42Folate biosynthesis_Homo sapiens_hsa007900.89944433
43Primary immunodeficiency_Homo sapiens_hsa053400.89243056
44Steroid biosynthesis_Homo sapiens_hsa001000.89214652
45Sphingolipid metabolism_Homo sapiens_hsa006000.87483529
46Maturity onset diabetes of the young_Homo sapiens_hsa049500.85120755
47Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.83735867
48Autoimmune thyroid disease_Homo sapiens_hsa053200.83589742
49Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.82859139
50Glutathione metabolism_Homo sapiens_hsa004800.82471591
51alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.81713635
52Selenocompound metabolism_Homo sapiens_hsa004500.80561613
53Butanoate metabolism_Homo sapiens_hsa006500.78204815
54Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.77485647
55Vitamin B6 metabolism_Homo sapiens_hsa007500.77289739
56Cardiac muscle contraction_Homo sapiens_hsa042600.74946370
57Caffeine metabolism_Homo sapiens_hsa002320.71639480
58mRNA surveillance pathway_Homo sapiens_hsa030150.71134079
59Hematopoietic cell lineage_Homo sapiens_hsa046400.67607955
60N-Glycan biosynthesis_Homo sapiens_hsa005100.67152162
61Metabolic pathways_Homo sapiens_hsa011000.65852597
62Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.64992379
63Intestinal immune network for IgA production_Homo sapiens_hsa046720.64089867
64Epstein-Barr virus infection_Homo sapiens_hsa051690.62091876
65Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.60548272
66p53 signaling pathway_Homo sapiens_hsa041150.58123214
67Allograft rejection_Homo sapiens_hsa053300.56690176
68Alcoholism_Homo sapiens_hsa050340.56446035
69Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.56410936
70Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.55460482
71Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.53639208
72Basal cell carcinoma_Homo sapiens_hsa052170.49844201
73Olfactory transduction_Homo sapiens_hsa047400.48664708
74Peroxisome_Homo sapiens_hsa041460.48579384
75Asthma_Homo sapiens_hsa053100.44404108
76Histidine metabolism_Homo sapiens_hsa003400.43933164
77Pentose and glucuronate interconversions_Homo sapiens_hsa000400.43893150
78Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.42649742
79Biosynthesis of amino acids_Homo sapiens_hsa012300.41981547
80Herpes simplex infection_Homo sapiens_hsa051680.41160660
81Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.39891779
82Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.39560415
83Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.39175738
84Rheumatoid arthritis_Homo sapiens_hsa053230.35279864
85Tryptophan metabolism_Homo sapiens_hsa003800.34736625
86Arginine and proline metabolism_Homo sapiens_hsa003300.34022087
87Taste transduction_Homo sapiens_hsa047420.32934092
88Chemical carcinogenesis_Homo sapiens_hsa052040.32761352
89Carbon metabolism_Homo sapiens_hsa012000.32359914
90beta-Alanine metabolism_Homo sapiens_hsa004100.31782690
91TGF-beta signaling pathway_Homo sapiens_hsa043500.31108320
92Other glycan degradation_Homo sapiens_hsa005110.30246755
93Drug metabolism - other enzymes_Homo sapiens_hsa009830.29631119
94Primary bile acid biosynthesis_Homo sapiens_hsa001200.29618134
95Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.29024962
96Oocyte meiosis_Homo sapiens_hsa041140.28955520
97Transcriptional misregulation in cancer_Homo sapiens_hsa052020.28475429
98Collecting duct acid secretion_Homo sapiens_hsa049660.27440556
99Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.26747423
100Vibrio cholerae infection_Homo sapiens_hsa051100.25565644
101NOD-like receptor signaling pathway_Homo sapiens_hsa046210.25009698
102Graft-versus-host disease_Homo sapiens_hsa053320.24507443
103Hedgehog signaling pathway_Homo sapiens_hsa043400.24251943
104Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.23523833
105Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.23434199
106Regulation of autophagy_Homo sapiens_hsa041400.22225446
107Pentose phosphate pathway_Homo sapiens_hsa000300.21834152
108Vitamin digestion and absorption_Homo sapiens_hsa049770.21584851
109NF-kappa B signaling pathway_Homo sapiens_hsa040640.21525673
110Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.19944613
111HTLV-I infection_Homo sapiens_hsa051660.19811214
112Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.19415858
113Serotonergic synapse_Homo sapiens_hsa047260.19132984
114Fatty acid metabolism_Homo sapiens_hsa012120.18101462
115Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.17233706
116Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.16725892
117Wnt signaling pathway_Homo sapiens_hsa043100.15918302
118Nicotine addiction_Homo sapiens_hsa050330.15812390
119Pyruvate metabolism_Homo sapiens_hsa006200.15482701
120Type I diabetes mellitus_Homo sapiens_hsa049400.14890005
121Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.13702616
122Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.11758522
123Propanoate metabolism_Homo sapiens_hsa006400.11353076
124Cysteine and methionine metabolism_Homo sapiens_hsa002700.10837158
125Measles_Homo sapiens_hsa051620.10288921
126Antigen processing and presentation_Homo sapiens_hsa046120.09559035
127Viral carcinogenesis_Homo sapiens_hsa052030.09406058
128Steroid hormone biosynthesis_Homo sapiens_hsa001400.09115579
129Retinol metabolism_Homo sapiens_hsa008300.09077084

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