ITGB7

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein that is a member of the integrin superfamily. Members of this family are adhesion receptors that function in signaling from the extracellular matrix to the cell. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. The encoded protein forms dimers with an alpha4 chain or an alphaE chain and plays a role in leukocyte adhesion. Dimerization with alpha4 forms a homing receptor for migration of lymphocytes to the intestinal mucosa and Peyer's patches. Dimerization with alphaE permits binding to the ligand epithelial cadherin, a calcium-dependent adhesion molecule. Alternate splicing results in multiple transcript variants. Additional alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of leukocyte mediated cytotoxicity (GO:0001911)7.49594763
2negative regulation of cell killing (GO:0031342)7.49594763
3positive regulation of gamma-delta T cell activation (GO:0046645)7.11366074
4antigen processing and presentation of endogenous peptide antigen (GO:0002483)6.88023620
5antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)6.88023620
6negative T cell selection (GO:0043383)6.62362400
7positive thymic T cell selection (GO:0045059)6.52736424
8negative thymic T cell selection (GO:0045060)6.46040174
9DNA strand renaturation (GO:0000733)6.40271753
10positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)6.18086027
11antigen processing and presentation of endogenous antigen (GO:0019883)6.06058041
12regulation of gamma-delta T cell differentiation (GO:0045586)6.04298522
13positive T cell selection (GO:0043368)5.80963297
14thymic T cell selection (GO:0045061)5.72012190
15response to interleukin-15 (GO:0070672)5.68213471
16regulation of gamma-delta T cell activation (GO:0046643)5.51312975
17cellular response to interleukin-15 (GO:0071350)5.41407075
18positive regulation of antigen processing and presentation (GO:0002579)5.41314470
19interferon-gamma production (GO:0032609)5.35343177
20negative regulation of bone resorption (GO:0045779)5.33656801
21regulation of isotype switching to IgG isotypes (GO:0048302)5.26891661
22T cell selection (GO:0045058)5.22190381
23regulation of B cell receptor signaling pathway (GO:0050855)5.13145466
24leukocyte aggregation (GO:0070486)5.06992181
25tolerance induction (GO:0002507)4.70588265
26* T cell migration (GO:0072678)4.68939358
27T cell receptor signaling pathway (GO:0050852)4.65202661
28negative regulation of B cell proliferation (GO:0030889)4.53527634
29positive regulation by organism of defense response of other organism involved in symbiotic interact4.47176802
30modulation by symbiont of host immune response (GO:0052553)4.47176802
31positive regulation by symbiont of host defense response (GO:0052509)4.47176802
32modulation by symbiont of host defense response (GO:0052031)4.47176802
33modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.47176802
34modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.47176802
35negative regulation of granulocyte differentiation (GO:0030853)4.43580056
36regulation of antigen processing and presentation (GO:0002577)4.39985603
37T cell costimulation (GO:0031295)4.35553162
38positive regulation of interleukin-2 biosynthetic process (GO:0045086)4.32955261
39lymphocyte costimulation (GO:0031294)4.28534556
40regulation of T cell tolerance induction (GO:0002664)4.26028525
41regulation of interferon-beta biosynthetic process (GO:0045357)4.23929927
42antigen receptor-mediated signaling pathway (GO:0050851)4.17125376
43apoptotic cell clearance (GO:0043277)4.16019794
44negative regulation of bone remodeling (GO:0046851)4.13423319
45immunoglobulin mediated immune response (GO:0016064)4.07372240
46regulation of antigen receptor-mediated signaling pathway (GO:0050854)4.05438465
47regulation of glucose import in response to insulin stimulus (GO:2001273)4.04542877
48activated T cell proliferation (GO:0050798)3.98690895
49positive regulation of protein export from nucleus (GO:0046827)3.98303772
50B cell homeostasis (GO:0001782)3.92053432
51macrophage activation involved in immune response (GO:0002281)3.91673367
52sequestering of actin monomers (GO:0042989)3.90714553
53antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.89498932
54T-helper cell differentiation (GO:0042093)3.78183025
55CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)3.78183025
56mast cell activation (GO:0045576)3.74427484
57antigen processing and presentation via MHC class Ib (GO:0002475)3.74015672
58regulation of B cell differentiation (GO:0045577)3.73475034
59B cell receptor signaling pathway (GO:0050853)3.71468041
60regulation of T cell receptor signaling pathway (GO:0050856)3.71315057
61peptidyl-lysine dimethylation (GO:0018027)3.70481482
62positive regulation of isotype switching (GO:0045830)3.68469035
63positive regulation of tolerance induction (GO:0002645)3.67340304
64regulation of alpha-beta T cell proliferation (GO:0046640)3.66655240
65regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.63634108
66negative regulation of T cell mediated immunity (GO:0002710)3.60094768
67regulation of granulocyte differentiation (GO:0030852)3.56593131
68negative regulation of tissue remodeling (GO:0034104)3.54157616
69regulation of interleukin-12 biosynthetic process (GO:0045075)3.51023976
70regulation of response to interferon-gamma (GO:0060330)3.48876769
71regulation of B cell proliferation (GO:0030888)3.47048873
72regulation of interferon-gamma-mediated signaling pathway (GO:0060334)3.46455107
73regulation of type I interferon-mediated signaling pathway (GO:0060338)3.45421708
74* leukocyte cell-cell adhesion (GO:0007159)3.44113513
75mitotic nuclear envelope reassembly (GO:0007084)3.41707667
76nuclear envelope reassembly (GO:0031468)3.41707667
77regulation of natural killer cell mediated immunity (GO:0002715)3.38234116
78regulation of natural killer cell mediated cytotoxicity (GO:0042269)3.38234116
79mucosal-associated lymphoid tissue development (GO:0048537)3.37613539
80Peyers patch development (GO:0048541)3.37613539
81regulation of isotype switching (GO:0045191)3.37178381
82regulation of regulatory T cell differentiation (GO:0045589)3.36878142
83regulation of monocyte differentiation (GO:0045655)3.36447522
84negative regulation of necroptotic process (GO:0060546)3.35934131
85regulation of necroptotic process (GO:0060544)3.33886757
86positive regulation of alpha-beta T cell proliferation (GO:0046641)3.33767707
87positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.32698602
88B cell mediated immunity (GO:0019724)3.29222926
89regulation of interleukin-2 biosynthetic process (GO:0045076)3.29123972
90T cell differentiation involved in immune response (GO:0002292)3.28756921
91alpha-beta T cell differentiation involved in immune response (GO:0002293)3.28756921
92alpha-beta T cell activation involved in immune response (GO:0002287)3.28756921
93mannose metabolic process (GO:0006013)3.26383839
94response to muramyl dipeptide (GO:0032495)3.25186922
95regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.24603426
96mast cell activation involved in immune response (GO:0002279)3.24346307
97mast cell degranulation (GO:0043303)3.24346307
98positive regulation of interleukin-2 production (GO:0032743)3.24183669
99positive regulation of DNA recombination (GO:0045911)3.21625579
100hepatocyte apoptotic process (GO:0097284)3.21563026
101Arp2/3 complex-mediated actin nucleation (GO:0034314)3.19661578
102regulation of tolerance induction (GO:0002643)3.19358139
103negative regulation of lymphocyte mediated immunity (GO:0002707)3.18532288
104NIK/NF-kappaB signaling (GO:0038061)3.17524722
105negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)3.16432341
106negative regulation of interleukin-12 production (GO:0032695)3.15993258
107cellular extravasation (GO:0045123)3.13938399
108natural killer cell activation (GO:0030101)3.13137906
109immune response-activating cell surface receptor signaling pathway (GO:0002429)3.12181312
110positive regulation of lamellipodium assembly (GO:0010592)3.12104403
111determination of adult lifespan (GO:0008340)3.10879180
112positive regulation of inflammatory response to antigenic stimulus (GO:0002863)3.10619225
113positive regulation of immunoglobulin production (GO:0002639)3.10056151
114positive regulation of B cell mediated immunity (GO:0002714)3.07645224
115positive regulation of immunoglobulin mediated immune response (GO:0002891)3.07645224
116positive regulation of interferon-alpha production (GO:0032727)3.07311864
117regulation of leukocyte mediated cytotoxicity (GO:0001910)3.07199142
118negative regulation of interleukin-6 production (GO:0032715)3.07041907
119CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)3.06347112
120JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)3.03277575
121positive regulation of natural killer cell mediated immunity (GO:0002717)3.03128919
122positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)3.03128919
123T cell homeostasis (GO:0043029)3.01653130
124cellular response to zinc ion (GO:0071294)3.01048437
125response to type I interferon (GO:0034340)3.00106612
126regulation of immunoglobulin mediated immune response (GO:0002889)2.99975502
127T cell differentiation (GO:0030217)2.99511412
128positive regulation of B cell differentiation (GO:0045579)2.98365492
129regulation of B cell mediated immunity (GO:0002712)2.96613037
130alpha-beta T cell activation (GO:0046631)2.96372946
131cellular response to type I interferon (GO:0071357)2.94675569
132type I interferon signaling pathway (GO:0060337)2.94675569
133response to peptidoglycan (GO:0032494)2.94662379
134regulation of immunoglobulin production (GO:0002637)2.93742706
135positive regulation of B cell activation (GO:0050871)2.91930717
136response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.91208225
137response to host immune response (GO:0052572)2.91208225
138T cell activation (GO:0042110)2.91197935
139negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.90519035
140negative regulation of catenin import into nucleus (GO:0035414)2.90207142
141lymphocyte homeostasis (GO:0002260)2.90123296
142regulation of defense response to virus by virus (GO:0050690)2.87440124
143N-acetylneuraminate metabolic process (GO:0006054)2.86772623
144neutrophil activation involved in immune response (GO:0002283)2.86379421
145regulation of interferon-alpha production (GO:0032647)2.85774483
146T cell proliferation (GO:0042098)2.85484497
147positive regulation of granulocyte differentiation (GO:0030854)2.85319289
148positive regulation of leukocyte mediated cytotoxicity (GO:0001912)2.83804630
149positive regulation of humoral immune response (GO:0002922)2.83087209
150regulation of cell killing (GO:0031341)2.82508136
151regulation of ARF protein signal transduction (GO:0032012)2.82318345
152lymphocyte chemotaxis (GO:0048247)2.82153798
153germinal center formation (GO:0002467)2.80933420
154negative regulation of T cell receptor signaling pathway (GO:0050860)2.80215448
155negative regulation of phagocytosis (GO:0050765)2.79675627
156alpha-beta T cell differentiation (GO:0046632)2.78459563
157mitochondrion distribution (GO:0048311)2.77964040
158interferon-gamma-mediated signaling pathway (GO:0060333)2.77420346
159regulation of activation of Janus kinase activity (GO:0010533)2.71435793
160regulation of B cell activation (GO:0050864)2.68735207
161negative regulation of necrotic cell death (GO:0060547)2.67416024
162response to host defenses (GO:0052200)2.63818976

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP3_17237761_ChIP-ChIP_TREG_Mouse5.83389971
2STAT6_20620947_ChIP-Seq_CD4_POS_T_Human4.94591639
3IRF8_22096565_ChIP-ChIP_GC-B_Human3.99906678
4MYC_22102868_ChIP-Seq_BL_Human3.65391820
5IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.31034891
6E2F7_22180533_ChIP-Seq_HELA_Human3.20491363
7* MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.13159010
8RUNX_20019798_ChIP-Seq_JUKART_Human2.99906698
9STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.97380061
10* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.94489464
11VDR_21846776_ChIP-Seq_THP-1_Human2.88779279
12STAT4_19710469_ChIP-ChIP_TH1__Mouse2.88772368
13MYB_26560356_Chip-Seq_TH2_Human2.88495903
14IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.83604308
15* MAF_26560356_Chip-Seq_TH1_Human2.82023730
16SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.79689160
17IRF8_21731497_ChIP-ChIP_J774_Mouse2.69534347
18UTX_26944678_Chip-Seq_JUKART_Human2.58975338
19* MYB_26560356_Chip-Seq_TH1_Human2.52923834
20* RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.44096141
21NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.29932220
22EGR1_19374776_ChIP-ChIP_THP-1_Human2.29839179
23* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.28506506
24* RUNX1_22412390_ChIP-Seq_EML_Mouse2.11751339
25* TCF7_22412390_ChIP-Seq_EML_Mouse2.05570242
26SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.05318694
27E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human2.03128036
28MYB_21317192_ChIP-Seq_ERMYB_Mouse2.02791688
29* MAF_26560356_Chip-Seq_TH2_Human2.02356012
30* SPI1_23547873_ChIP-Seq_NB4_Human2.02216768
31KDM2B_26808549_Chip-Seq_HPB-ALL_Human2.01539868
32NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.98932616
33IRF8_27001747_Chip-Seq_BMDM_Mouse1.98498097
34VDR_24763502_ChIP-Seq_THP-1_Human1.95345476
35NOTCH1_21737748_ChIP-Seq_TLL_Human1.92619993
36SCL_19346495_ChIP-Seq_HPC-7_Human1.84510756
37KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.83818274
38BRD4_27068464_Chip-Seq_AML-cells_Mouse1.83624959
39KDM2B_26808549_Chip-Seq_DND41_Human1.82418467
40BP1_19119308_ChIP-ChIP_Hs578T_Human1.81037849
41EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.79212610
42ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.79021943
43FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.76483389
44GATA3_27048872_Chip-Seq_THYMUS_Human1.67428155
45NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.66924475
46TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.64808378
47ELF1_17652178_ChIP-ChIP_JURKAT_Human1.59460310
48MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.59287656
49KDM2B_26808549_Chip-Seq_SUP-B15_Human1.57301819
50BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.57088788
51SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.49698090
52ELK3_25401928_ChIP-Seq_HUVEC_Human1.49072197
53FOXM1_23109430_ChIP-Seq_U2OS_Human1.45940114
54SPI1_23127762_ChIP-Seq_K562_Human1.45745212
55IKZF1_21737484_ChIP-ChIP_HCT116_Human1.43307519
56NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.41496283
57GATA2_22383799_ChIP-Seq_G1ME_Mouse1.33281826
58* PU.1_20513432_ChIP-Seq_Bcells_Mouse1.28540509
59CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.26576704
60VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.23573950
61CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.23506170
62GATA1_22383799_ChIP-Seq_G1ME_Mouse1.22387208
63RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.22090744
64PU_27001747_Chip-Seq_BMDM_Mouse1.20569743
65TFEB_21752829_ChIP-Seq_HELA_Human1.19645785
66CIITA_25753668_ChIP-Seq_RAJI_Human1.19613423
67TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.17573182
68GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.16455486
69* TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.16189991
70KDM2B_26808549_Chip-Seq_JURKAT_Human1.12951284
71* CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.12923116
72* LXR_22292898_ChIP-Seq_THP-1_Human1.12414251
73* LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.11946158
74* SA1_27219007_Chip-Seq_ERYTHROID_Human1.09960781
75VDR_23849224_ChIP-Seq_CD4+_Human1.09123929
76RACK7_27058665_Chip-Seq_MCF-7_Human1.08878655
77GATA1_19941826_ChIP-Seq_K562_Human1.08711755
78PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.08155561
79* PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.08065881
80PKCTHETA_26484144_Chip-Seq_BREAST_Human1.07782198
81SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.07537588
82RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.06702543
83ERG_20887958_ChIP-Seq_HPC-7_Mouse1.06319387
84* PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.06021140
85GATA3_26560356_Chip-Seq_TH2_Human1.01934679
86CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.01933189
87P68_20966046_ChIP-Seq_HELA_Human1.01761618
88CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.99202649
89STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.98536020
90* CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.97161897
91NCOR1_26117541_ChIP-Seq_K562_Human0.96652767
92FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.96017691
93GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.95524154
94HCFC1_20581084_ChIP-Seq_MESCs_Mouse0.94519256
95ETS1_21867929_ChIP-Seq_TH2_Mouse0.94390622
96* GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.94086077
97LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.94059023
98FOXP3_21729870_ChIP-Seq_TREG_Human0.93243204
99MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse0.91565977
100* GATA1_19941827_ChIP-Seq_MEL_Mouse0.91129375
101CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.90951324
102SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.90565908
103RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.87692355
104BCOR_27268052_Chip-Seq_Bcells_Human0.87583234
105HOXB4_20404135_ChIP-ChIP_EML_Mouse0.87504240
106YY1_21170310_ChIP-Seq_MESCs_Mouse0.87390891
107THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.87155292
108SOX11_23321250_ChIP-ChIP_Z138-A519-JVM2_Human0.86905279
109KDM2B_26808549_Chip-Seq_K562_Human0.86333383
110E2F1_21310950_ChIP-Seq_MCF-7_Human0.84553752
111* ETS1_22383799_ChIP-Seq_G1ME_Mouse0.84125981
112E2F4_17652178_ChIP-ChIP_JURKAT_Human0.83768731
113CTCF_27219007_Chip-Seq_ERYTHROID_Human0.83078371
114FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.81817905
115BCL6_27268052_Chip-Seq_Bcells_Human0.81327623
116CTCF_21964334_ChIP-Seq_BJAB-B_Human0.80264583
117MYC_19079543_ChIP-ChIP_MESCs_Mouse0.77333511
118SRY_22984422_ChIP-ChIP_TESTIS_Rat0.76246427
119ELF1_20517297_ChIP-Seq_JURKAT_Human0.75975484
120SPI1_20517297_ChIP-Seq_HL60_Human0.75866265
121DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.75654042
122CTCF_26484167_Chip-Seq_Bcells_Mouse0.74825189
123MYC_18555785_ChIP-Seq_MESCs_Mouse0.74533428
124FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human0.74250991

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003763_abnormal_thymus_physiology4.86164431
2MP0005671_abnormal_response_to3.94826837
3MP0001835_abnormal_antigen_presentation3.62340242
4MP0001800_abnormal_humoral_immune3.27768182
5* MP0000685_abnormal_immune_system3.22595519
6* MP0001790_abnormal_immune_system2.95620703
7* MP0005387_immune_system_phenotype2.95620703
8MP0005000_abnormal_immune_tolerance2.90705355
9* MP0002420_abnormal_adaptive_immunity2.86752704
10* MP0001819_abnormal_immune_cell2.83339447
11MP0002723_abnormal_immune_serum2.83100859
12MP0002166_altered_tumor_susceptibility2.82410138
13* MP0002398_abnormal_bone_marrow2.80740466
14MP0009333_abnormal_splenocyte_physiolog2.75997573
15MP0002452_abnormal_antigen_presenting2.72906700
16MP0002405_respiratory_system_inflammati2.57870401
17MP0003436_decreased_susceptibility_to2.54821745
18MP0001873_stomach_inflammation2.54207361
19MP0009785_altered_susceptibility_to2.53167311
20* MP0005025_abnormal_response_to2.52140849
21* MP0000716_abnormal_immune_system2.46520821
22MP0006082_CNS_inflammation2.45366114
23MP0002396_abnormal_hematopoietic_system2.41922378
24MP0003878_abnormal_ear_physiology2.40678301
25MP0005377_hearing/vestibular/ear_phenot2.40678301
26MP0000703_abnormal_thymus_morphology2.38331382
27MP0004043_abnormal_pH_regulation2.35471844
28* MP0002722_abnormal_immune_system2.30749431
29MP0000689_abnormal_spleen_morphology2.30411402
30MP0002006_tumorigenesis2.29532227
31MP0005464_abnormal_platelet_physiology2.12282840
32MP0002419_abnormal_innate_immunity2.11614793
33MP0003866_abnormal_defecation2.11303437
34MP0004947_skin_inflammation2.11169709
35* MP0002429_abnormal_blood_cell2.05111048
36MP0003303_peritoneal_inflammation2.01954900
37* MP0010155_abnormal_intestine_physiology2.00559330
38MP0003300_gastrointestinal_ulcer1.99811469
39MP0003724_increased_susceptibility_to1.98196060
40MP0002148_abnormal_hypersensitivity_rea1.97205281
41MP0004510_myositis1.87243642
42MP0005451_abnormal_body_composition1.85149690
43* MP0001845_abnormal_inflammatory_respons1.71641679
44MP0000465_gastrointestinal_hemorrhage1.56093320
45MP0004808_abnormal_hematopoietic_stem1.54994379
46MP0009278_abnormal_bone_marrow1.54563272
47MP0001853_heart_inflammation1.52975227
48MP0000858_altered_metastatic_potential1.46437697
49MP0005397_hematopoietic_system_phenotyp1.46391135
50MP0001545_abnormal_hematopoietic_system1.46391135
51MP0002009_preneoplasia1.44939548
52MP0002638_abnormal_pupillary_reflex1.44727174
53MP0000490_abnormal_crypts_of1.44197338
54MP0008057_abnormal_DNA_replication1.42366688
55MP0005075_abnormal_melanosome_morpholog1.42159671
56MP0005174_abnormal_tail_pigmentation1.40076084
57MP0002102_abnormal_ear_morphology1.33857542
58MP0005310_abnormal_salivary_gland1.33686622
59MP0003879_abnormal_hair_cell1.29174096
60MP0003448_altered_tumor_morphology1.28961847
61MP0002089_abnormal_postnatal_growth/wei1.22939553
62MP0010352_gastrointestinal_tract_polyps1.19809018
63* MP0002933_joint_inflammation1.19794341
64MP0002019_abnormal_tumor_incidence1.18573962
65MP0003172_abnormal_lysosome_physiology1.16914515
66MP0001348_abnormal_lacrimal_gland1.15866925
67MP0008469_abnormal_protein_level1.15755540
68MP0001533_abnormal_skeleton_physiology1.14422481
69MP0008995_early_reproductive_senescence1.12885244
70MP0008569_lethality_at_weaning1.12687991
71MP0001851_eye_inflammation1.10078025
72MP0003045_fibrosis1.09186493
73MP0002132_abnormal_respiratory_system1.08022984
74MP0009840_abnormal_foam_cell1.06923247
75MP0005058_abnormal_lysosome_morphology1.01872259
76MP0008260_abnormal_autophagy0.98839307
77MP0004264_abnormal_extraembryonic_tissu0.92222521
78MP0005023_abnormal_wound_healing0.90463776
79MP0005220_abnormal_exocrine_pancreas0.90441940
80MP0003077_abnormal_cell_cycle0.88088434
81MP0002163_abnormal_gland_morphology0.87431969
82MP0005076_abnormal_cell_differentiation0.87285631
83MP0002998_abnormal_bone_remodeling0.84725891
84MP0004381_abnormal_hair_follicle0.84382237
85MP0004742_abnormal_vestibular_system0.83331694
86MP0002138_abnormal_hepatobiliary_system0.80797432
87MP0003453_abnormal_keratinocyte_physiol0.80422155
88MP0000015_abnormal_ear_pigmentation0.79443796
89MP0005423_abnormal_somatic_nervous0.78929097
90MP0002693_abnormal_pancreas_physiology0.78449057
91MP0003656_abnormal_erythrocyte_physiolo0.77456609
92MP0002332_abnormal_exercise_endurance0.72154913
93MP0003693_abnormal_embryo_hatching0.72042732
94MP0010094_abnormal_chromosome_stability0.71874141
95MP0001765_abnormal_ion_homeostasis0.70862866
96MP0003221_abnormal_cardiomyocyte_apopto0.70649607
97MP0005171_absent_coat_pigmentation0.70218242
98MP0008004_abnormal_stomach_pH0.69983351
99MP0000477_abnormal_intestine_morphology0.69107875
100MP0010307_abnormal_tumor_latency0.67305812
101MP0009763_increased_sensitivity_to0.66415852
102MP0005381_digestive/alimentary_phenotyp0.65498963
103MP0004957_abnormal_blastocyst_morpholog0.64725802
104MP0003566_abnormal_cell_adhesion0.63248476
105MP0010234_abnormal_vibrissa_follicle0.62649812
106MP0000371_diluted_coat_color0.62042269
107MP0001919_abnormal_reproductive_system0.59686578
108MP0008961_abnormal_basal_metabolism0.59224382
109MP0000343_altered_response_to0.58501172
110MP0003111_abnormal_nucleus_morphology0.58120019
111MP0000313_abnormal_cell_death0.57540346
112MP0001663_abnormal_digestive_system0.54695186
113MP0003828_pulmonary_edema0.54631260
114MP0000609_abnormal_liver_physiology0.54353257
115MP0008058_abnormal_DNA_repair0.54202130
116MP0009765_abnormal_xenobiotic_induced0.54177108
117MP0000920_abnormal_myelination0.52968309
118MP0003183_abnormal_peptide_metabolism0.52342046
119MP0002083_premature_death0.52190881
120MP0002136_abnormal_kidney_physiology0.51267264
121MP0000249_abnormal_blood_vessel0.48976183
122MP0005390_skeleton_phenotype0.48228976
123MP0005166_decreased_susceptibility_to0.48186774
124MP0003795_abnormal_bone_structure0.48182789
125MP0008873_increased_physiological_sensi0.44692201
126MP0000350_abnormal_cell_proliferation0.44327373
127MP0009764_decreased_sensitivity_to0.43374644
128MP0003091_abnormal_cell_migration0.43271092
129MP0003191_abnormal_cellular_cholesterol0.42606221
130* MP0002086_abnormal_extraembryonic_tissu0.42226769
131MP0002095_abnormal_skin_pigmentation0.41942489

Predicted human phenotypes

RankGene SetZ-score
1T lymphocytopenia (HP:0005403)5.98178696
2Decreased circulating renin level (HP:0003351)5.68783842
3Abnormality of T cell number (HP:0011839)5.68560315
4Hyperactive renin-angiotensin system (HP:0000841)5.64330589
5IgM deficiency (HP:0002850)5.17579783
6Pustule (HP:0200039)5.17024670
7Nasal polyposis (HP:0100582)5.10573280
8Recurrent bronchitis (HP:0002837)4.99217408
9Elevated erythrocyte sedimentation rate (HP:0003565)4.93646233
10Abnormality of T cells (HP:0002843)4.92909491
11Chronic otitis media (HP:0000389)4.82827130
12Hypokalemic alkalosis (HP:0001949)4.60136382
13Recurrent fungal infections (HP:0002841)4.54863960
14Abnormality of the nasal mucosa (HP:0000433)4.35293644
15Myositis (HP:0100614)4.31326202
16Abnormal delayed hypersensitivity skin test (HP:0002963)4.26714685
17Nuclear cataract (HP:0100018)4.22211151
18Eczematoid dermatitis (HP:0000976)4.18623483
19Stomatitis (HP:0010280)4.11314077
20Achilles tendon contracture (HP:0001771)4.09592110
21Recurrent viral infections (HP:0004429)4.06115783
22Severe combined immunodeficiency (HP:0004430)3.98628859
23Chronic mucocutaneous candidiasis (HP:0002728)3.98609991
24Recurrent cutaneous fungal infections (HP:0011370)3.98609991
25Combined immunodeficiency (HP:0005387)3.91864642
26Panhypogammaglobulinemia (HP:0003139)3.87386421
27Abnormality of T cell physiology (HP:0011840)3.85875796
28Recurrent abscess formation (HP:0002722)3.83567001
29IgG deficiency (HP:0004315)3.81876694
30Large eyes (HP:0001090)3.72710271
31Hyperkalemia (HP:0002153)3.68630687
32Abnormality of the Achilles tendon (HP:0005109)3.67649812
33Chronic bronchitis (HP:0004469)3.53205002
34Increased IgM level (HP:0003496)3.49807156
35Inflammation of the large intestine (HP:0002037)3.46776312
36Gastrointestinal inflammation (HP:0004386)3.36419137
37Zonular cataract (HP:0010920)3.21409997
38Lymphopenia (HP:0001888)3.16876721
39Meningitis (HP:0001287)3.13576621
40Muscle fiber atrophy (HP:0100295)3.09913283
41Hyponatremia (HP:0002902)3.09162831
42Abnormality of cells of the lymphoid lineage (HP:0012140)3.06857337
43Spontaneous hematomas (HP:0007420)3.04771265
44Abnormality of the fingertips (HP:0001211)3.01887962
45Abnormality of eosinophils (HP:0001879)3.01157457
46IgA deficiency (HP:0002720)3.00512026
47Recurrent skin infections (HP:0001581)2.97615481
48Leukocytosis (HP:0001974)2.96889210
49Retrobulbar optic neuritis (HP:0100654)2.96498938
50Optic neuritis (HP:0100653)2.96498938
51Abnormality of incisor morphology (HP:0011063)2.94189686
52Basal cell carcinoma (HP:0002671)2.92754924
53Prolonged bleeding time (HP:0003010)2.91715489
54Orchitis (HP:0100796)2.91367530
55Thyroiditis (HP:0100646)2.91297197
56Recurrent bacterial skin infections (HP:0005406)2.91220079
57Autoimmune hemolytic anemia (HP:0001890)2.86842967
58Premature loss of primary teeth (HP:0006323)2.86808803
59Atrioventricular block (HP:0001678)2.85438801
60Obstructive lung disease (HP:0006536)2.84723991
61Chronic obstructive pulmonary disease (HP:0006510)2.84723991
62Vasculitis (HP:0002633)2.81748941
63Colitis (HP:0002583)2.81192196
64Conical tooth (HP:0000698)2.80981120
65Increased IgE level (HP:0003212)2.80044741
66Onycholysis (HP:0001806)2.74664247
67Chronic diarrhea (HP:0002028)2.73994710
68Agammaglobulinemia (HP:0004432)2.73753150
69Bronchitis (HP:0012387)2.73137194
70Mediastinal lymphadenopathy (HP:0100721)2.72700608
71Recurrent sinusitis (HP:0011108)2.72088638
72Renal salt wasting (HP:0000127)2.71530402
73Encephalitis (HP:0002383)2.71111259
74Cone-rod dystrophy (HP:0000548)2.69850139
75Dry hair (HP:0011359)2.66271801
76Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.64692281
77Petechiae (HP:0000967)2.64373458
78Abnormality of renin-angiotensin system (HP:0000847)2.60751058
79Hypergammaglobulinemia (HP:0010702)2.58462844
80Reduced subcutaneous adipose tissue (HP:0003758)2.57134509
81Hemoptysis (HP:0002105)2.57095063
82Increased cerebral lipofuscin (HP:0011813)2.56834485
83Abnormality of B cell number (HP:0010975)2.55801819
84B lymphocytopenia (HP:0010976)2.55801819
85Eosinophilia (HP:0001880)2.55303900
86Lymphoma (HP:0002665)2.55062167
87Increased neuronal autofluorescent lipopigment (HP:0002074)2.54522336
88Autoimmune thrombocytopenia (HP:0001973)2.54321505
89Abnormal platelet volume (HP:0011876)2.53776160
90Hyperaldosteronism (HP:0000859)2.53387908
91Epistaxis (HP:0000421)2.52074824
92Joint swelling (HP:0001386)2.51305757
93Erythema (HP:0010783)2.50992712
94Poikiloderma (HP:0001029)2.48523836
95Flat capital femoral epiphysis (HP:0003370)2.47568324
96Overlapping toe (HP:0001845)2.46407459
97Verrucae (HP:0200043)2.45740651
98Papilloma (HP:0012740)2.45740651
99Cheilitis (HP:0100825)2.41647266
100Pulmonary infiltrates (HP:0002113)2.41445092
101Urticaria (HP:0001025)2.41010850
102Chronic sinusitis (HP:0011109)2.40176882
103Abnormality of chloride homeostasis (HP:0011422)2.36280035
104Joint contractures involving the joints of the feet (HP:0100492)2.35997833
105Flexion contracture of toe (HP:0005830)2.35997833
106Thrombocytosis (HP:0001894)2.35630710
107Acute hepatic failure (HP:0006554)2.34407110
108Granulocytopenia (HP:0001913)2.34196075
109Alkalosis (HP:0001948)2.28812107
110Gingival bleeding (HP:0000225)2.21617274
111Gastrointestinal infarctions (HP:0005244)2.21307362
112Basal ganglia calcification (HP:0002135)2.20047648
113Shawl scrotum (HP:0000049)2.18916463
114Abnormality of sodium homeostasis (HP:0010931)2.18646717
115Arterial thrombosis (HP:0004420)2.16389205
116Cellulitis (HP:0100658)2.15696933
117Increased density of long bones (HP:0006392)2.14544378
118Keratoconjunctivitis sicca (HP:0001097)2.14073754
119Elbow flexion contracture (HP:0002987)2.13805216
120Abnormality of macrophages (HP:0004311)2.13038518
121Ridged nail (HP:0001807)2.11218019
122Emphysema (HP:0002097)2.10275380
123Prominent nose (HP:0000448)2.09726872
124Recurrent gram-negative bacterial infections (HP:0005420)2.07566926
125Progressive visual loss (HP:0000529)2.06578256
126Chest pain (HP:0100749)2.06114579
127Blepharitis (HP:0000498)2.05978477
128Trismus (HP:0000211)2.04645914
129Recurrent otitis media (HP:0000403)2.04264463
130J-shaped sella turcica (HP:0002680)2.01919051
131Viral hepatitis (HP:0006562)2.01244928
132Hypoplasia of the thymus (HP:0000778)1.99895414
133Pulmonary embolism (HP:0002204)1.99624791
134Skin ulcer (HP:0200042)1.99509127
135Albinism (HP:0001022)1.98873131
136Squamous cell carcinoma (HP:0002860)1.96810207
137Skin rash (HP:0000988)1.95811316
138Increased mean platelet volume (HP:0011877)1.94821190
139Gingivitis (HP:0000230)1.92476216
140Keratoconjunctivitis (HP:0001096)1.91651202
141Microcytic anemia (HP:0001935)1.91236860
142Abnormality of the prostate (HP:0008775)1.90071611
143Gastrointestinal stroma tumor (HP:0100723)1.89645080
144Subacute progressive viral hepatitis (HP:0006572)1.89416020
145Dysostosis multiplex (HP:0000943)1.86413485
146Interstitial pulmonary disease (HP:0006530)1.85674308
147Anorexia (HP:0002039)1.85124794
148Bronchiectasis (HP:0002110)1.84512103
149Periodontitis (HP:0000704)1.82392696
150Impaired platelet aggregation (HP:0003540)1.78892664
151Abnormal platelet function (HP:0011869)1.78892664

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K16.22768132
2PRPF4B4.87423616
3TXK4.65971854
4MOS3.38216136
5ZAP703.04005198
6GRK72.97679323
7JAK32.95558584
8STK102.72901169
9ITK2.71977011
10TYK22.63572610
11GRK62.63300070
12FGFR42.45861123
13IKBKE2.26560671
14CSK2.12505047
15JAK12.07706047
16BLK1.89581439
17LCK1.82751611
18EEF2K1.72304963
19TBK11.72293806
20TESK21.71929359
21KIT1.62925045
22MAP3K101.60459538
23NME21.56734182
24BTK1.56662783
25SMG11.55519444
26SYK1.51220300
27RIPK41.49783439
28FGFR31.47570171
29MAP3K141.45460848
30TEC1.45057691
31NLK1.44963239
32SIK11.44009062
33HCK1.37416644
34MAP3K131.34698445
35PKN21.32557343
36KDR1.32407819
37IRAK41.31472449
38PIM11.27373222
39GRK51.25518527
40TRIB31.19960189
41RAF11.19542323
42LRRK21.19033058
43MARK31.19031836
44IKBKB1.12716548
45SIK21.12213830
46MAP3K111.10873307
47TNK21.04378027
48FES1.04048972
49CSF1R0.99163805
50PRKCH0.97831039
51MST40.97676743
52TYRO30.95869948
53MAPK120.93865990
54JAK20.93805378
55CLK10.93751228
56PRKD20.93477504
57LYN0.93017654
58IRAK20.92970475
59KSR20.89869302
60FLT30.88635169
61EPHB10.86769001
62RPS6KA40.85792673
63MAP2K30.84853493
64PRKCQ0.83904416
65EIF2AK20.82311913
66TGFBR20.80415141
67TAOK30.79332703
68TTN0.77303256
69CDK120.73642572
70ERN10.71725878
71CDK40.71299695
72CCNB10.69336594
73PIK3CG0.68794790
74ARAF0.67669673
75IRAK30.65597017
76CHUK0.63028868
77FGR0.59531792
78TAOK20.58808863
79PDGFRB0.57159513
80MAPK110.57089785
81ICK0.55139444
82HIPK20.54761240
83NEK20.54217428
84CDK60.53497310
85RPS6KA60.52438241
86ALK0.51122092
87TRPM70.49350971
88UHMK10.48719842
89MAPK70.48517435
90MAP3K10.48457167
91EIF2AK30.48027574
92SIK30.47916977
93MAP3K70.47489055
94MAP2K60.46507792
95TAOK10.46153792
96MAP3K60.46097030
97PDK10.45660515
98MELK0.45543764
99RPS6KL10.45158250
100RPS6KC10.45158250
101DAPK10.44801342
102BRAF0.44431693
103SGK30.43912631
104BMX0.43209470
105STK40.42988912
106MAP3K120.42912201
107MAP2K20.42351140
108YES10.40685348
109PAK10.38283898
110MAP3K80.37998844
111MAP3K30.37048207
112EPHA30.36241032
113PIM20.35967689
114AURKA0.35571303
115MARK20.33534045
116INSR0.33176626
117DYRK1B0.32958924
118STK240.31509861
119MAPK40.30574339
120MAPK30.30224413
121MATK0.29445138
122FYN0.29318164
123SGK20.29021887
124CDK70.28785043
125MAPKAPK20.27748933
126PDPK10.27289196
127RPS6KB20.26110799
128SCYL20.26097750
129PTK60.25602627
130MTOR0.25041944
131DMPK0.24799960

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053405.22933570
2T cell receptor signaling pathway_Homo sapiens_hsa046603.26709050
3Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.98953394
4Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.93149417
5Measles_Homo sapiens_hsa051622.64739821
6Antigen processing and presentation_Homo sapiens_hsa046122.48138345
7NF-kappa B signaling pathway_Homo sapiens_hsa040642.32130371
8Hematopoietic cell lineage_Homo sapiens_hsa046402.28508632
9B cell receptor signaling pathway_Homo sapiens_hsa046622.16201857
10Leishmaniasis_Homo sapiens_hsa051402.15885495
11Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049602.07939468
12Osteoclast differentiation_Homo sapiens_hsa043802.06764657
13* Intestinal immune network for IgA production_Homo sapiens_hsa046722.06642004
14Graft-versus-host disease_Homo sapiens_hsa053322.02924405
15Allograft rejection_Homo sapiens_hsa053302.00812747
16Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.92893512
17N-Glycan biosynthesis_Homo sapiens_hsa005101.89968830
18Jak-STAT signaling pathway_Homo sapiens_hsa046301.81625174
19Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.78058043
20Cyanoamino acid metabolism_Homo sapiens_hsa004601.73134507
21Viral myocarditis_Homo sapiens_hsa054161.72996618
22Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.69763859
23Herpes simplex infection_Homo sapiens_hsa051681.63042136
24RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.50372462
25Shigellosis_Homo sapiens_hsa051311.49008546
26Chemokine signaling pathway_Homo sapiens_hsa040621.47365376
27Staphylococcus aureus infection_Homo sapiens_hsa051501.45364073
28Acute myeloid leukemia_Homo sapiens_hsa052211.44416583
29Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.42613192
30Asthma_Homo sapiens_hsa053101.41210644
31Autoimmune thyroid disease_Homo sapiens_hsa053201.38999844
32Leukocyte transendothelial migration_Homo sapiens_hsa046701.36335736
33Toxoplasmosis_Homo sapiens_hsa051451.36181341
34Hepatitis B_Homo sapiens_hsa051611.30119634
35Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.26388776
36Toll-like receptor signaling pathway_Homo sapiens_hsa046201.14766460
37Mismatch repair_Homo sapiens_hsa034301.14114409
38Apoptosis_Homo sapiens_hsa042101.13880362
39Influenza A_Homo sapiens_hsa051641.13017382
40Base excision repair_Homo sapiens_hsa034101.12899855
41DNA replication_Homo sapiens_hsa030301.12294961
42NOD-like receptor signaling pathway_Homo sapiens_hsa046211.12254745
43Pancreatic cancer_Homo sapiens_hsa052121.10502124
44Platelet activation_Homo sapiens_hsa046111.09693072
45Ribosome_Homo sapiens_hsa030101.09678083
46Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.09625204
47ABC transporters_Homo sapiens_hsa020101.08680141
48Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.08377604
49Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.07845968
50VEGF signaling pathway_Homo sapiens_hsa043701.06767558
51Chronic myeloid leukemia_Homo sapiens_hsa052201.05375421
52HTLV-I infection_Homo sapiens_hsa051661.02480990
53Legionellosis_Homo sapiens_hsa051341.00816943
54Colorectal cancer_Homo sapiens_hsa052100.99787908
55Epstein-Barr virus infection_Homo sapiens_hsa051690.97811453
56Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.97258686
57TNF signaling pathway_Homo sapiens_hsa046680.96078031
58Tuberculosis_Homo sapiens_hsa051520.92186296
59Pertussis_Homo sapiens_hsa051330.89242728
60Malaria_Homo sapiens_hsa051440.88940874
61Other glycan degradation_Homo sapiens_hsa005110.88110384
62Spliceosome_Homo sapiens_hsa030400.87410755
63Viral carcinogenesis_Homo sapiens_hsa052030.86258690
64Notch signaling pathway_Homo sapiens_hsa043300.82767762
65p53 signaling pathway_Homo sapiens_hsa041150.82376942
66Salmonella infection_Homo sapiens_hsa051320.78769573
67AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.78707833
68Hepatitis C_Homo sapiens_hsa051600.78469885
69Prolactin signaling pathway_Homo sapiens_hsa049170.78078736
70Carbohydrate digestion and absorption_Homo sapiens_hsa049730.76443331
71Phagosome_Homo sapiens_hsa041450.74510349
72Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.73476887
73* Transcriptional misregulation in cancer_Homo sapiens_hsa052020.70569243
74Non-small cell lung cancer_Homo sapiens_hsa052230.70072187
75* Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.69991033
76Bladder cancer_Homo sapiens_hsa052190.69855966
77Neurotrophin signaling pathway_Homo sapiens_hsa047220.68569458
78Systemic lupus erythematosus_Homo sapiens_hsa053220.68196867
79* Regulation of actin cytoskeleton_Homo sapiens_hsa048100.67632145
80Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.66990965
81Central carbon metabolism in cancer_Homo sapiens_hsa052300.63128646
82Rheumatoid arthritis_Homo sapiens_hsa053230.62216847
83Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.61938154
84Small cell lung cancer_Homo sapiens_hsa052220.59316406
85Phospholipase D signaling pathway_Homo sapiens_hsa040720.58897934
86Endocytosis_Homo sapiens_hsa041440.58705826
87mTOR signaling pathway_Homo sapiens_hsa041500.58327398
88Glycosaminoglycan degradation_Homo sapiens_hsa005310.53740277
89Fructose and mannose metabolism_Homo sapiens_hsa000510.50526658
90Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.49955117
91Glioma_Homo sapiens_hsa052140.49025331
92Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.47997518
93Homologous recombination_Homo sapiens_hsa034400.47270997
94Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.46025947
95Sphingolipid signaling pathway_Homo sapiens_hsa040710.45348246
96mRNA surveillance pathway_Homo sapiens_hsa030150.45164108
97FoxO signaling pathway_Homo sapiens_hsa040680.45021134
98Phosphatidylinositol signaling system_Homo sapiens_hsa040700.43413043
99MAPK signaling pathway_Homo sapiens_hsa040100.43393452
100Pentose phosphate pathway_Homo sapiens_hsa000300.43324541
101Rap1 signaling pathway_Homo sapiens_hsa040150.41998826
102Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.39948847
103Nucleotide excision repair_Homo sapiens_hsa034200.39514687
104Adherens junction_Homo sapiens_hsa045200.38177401
105RNA degradation_Homo sapiens_hsa030180.38033594
106Non-homologous end-joining_Homo sapiens_hsa034500.37473546
107Lysosome_Homo sapiens_hsa041420.37208180
108Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.34214418
109RNA transport_Homo sapiens_hsa030130.33832729
110Renal cell carcinoma_Homo sapiens_hsa052110.33809436
111Fanconi anemia pathway_Homo sapiens_hsa034600.32863471
112Type I diabetes mellitus_Homo sapiens_hsa049400.32295614
113Choline metabolism in cancer_Homo sapiens_hsa052310.31570189
114Endometrial cancer_Homo sapiens_hsa052130.30853992
115HIF-1 signaling pathway_Homo sapiens_hsa040660.30761761
116Biosynthesis of amino acids_Homo sapiens_hsa012300.30606902
117Cell cycle_Homo sapiens_hsa041100.30351640
118Insulin resistance_Homo sapiens_hsa049310.29634657
119GnRH signaling pathway_Homo sapiens_hsa049120.29347082
120Thyroid cancer_Homo sapiens_hsa052160.28734629
121Inositol phosphate metabolism_Homo sapiens_hsa005620.28593031
122Prion diseases_Homo sapiens_hsa050200.28340603
123Pathways in cancer_Homo sapiens_hsa052000.27604051
124Prostate cancer_Homo sapiens_hsa052150.25355831
125Vitamin B6 metabolism_Homo sapiens_hsa007500.25307603
126ErbB signaling pathway_Homo sapiens_hsa040120.23954940
127Thyroid hormone signaling pathway_Homo sapiens_hsa049190.23575731

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