ITIH2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The inter-alpha-trypsin inhibitors (ITI) are a family of structurally related plasma serine protease inhibitors involved in extracellular matrix stabilization and in prevention of tumor metastasis. The ITI family contains multiple proteins made up of a light chain (see MIM 176870) and a variable number of heavy chains (Salier et al., 1987 [PubMed 2446322]; Himmelfarb et al., 2004 [PubMed 14744536]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)7.54503428
2L-phenylalanine catabolic process (GO:0006559)7.54503428
3erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)7.20259288
4L-phenylalanine metabolic process (GO:0006558)7.20259288
5aromatic amino acid family catabolic process (GO:0009074)6.72155466
6triglyceride-rich lipoprotein particle remodeling (GO:0034370)6.46375237
7indole-containing compound catabolic process (GO:0042436)6.00189188
8indolalkylamine catabolic process (GO:0046218)6.00189188
9tryptophan catabolic process (GO:0006569)6.00189188
10kynurenine metabolic process (GO:0070189)5.92752843
11intestinal cholesterol absorption (GO:0030299)5.91957862
12negative regulation of fibrinolysis (GO:0051918)5.88693367
13bile acid biosynthetic process (GO:0006699)5.86163211
14glyoxylate metabolic process (GO:0046487)5.78346159
15urea cycle (GO:0000050)5.72523984
16urea metabolic process (GO:0019627)5.72523984
17regulation of plasminogen activation (GO:0010755)5.72224905
18regulation of apoptotic cell clearance (GO:2000425)5.72180755
19high-density lipoprotein particle remodeling (GO:0034375)5.71978199
20tryptophan metabolic process (GO:0006568)5.66723532
21regulation of fibrinolysis (GO:0051917)5.64973181
22alpha-linolenic acid metabolic process (GO:0036109)5.55852666
23protein carboxylation (GO:0018214)5.45758259
24peptidyl-glutamic acid carboxylation (GO:0017187)5.45758259
25regulation of protein activation cascade (GO:2000257)5.44924578
26cysteine metabolic process (GO:0006534)5.40058404
27complement activation, alternative pathway (GO:0006957)5.38003352
28sulfur amino acid catabolic process (GO:0000098)5.35755779
29nitrogen cycle metabolic process (GO:0071941)5.25540485
30serine family amino acid catabolic process (GO:0009071)5.10486455
31reverse cholesterol transport (GO:0043691)5.07427614
32regulation of complement activation (GO:0030449)5.06141859
33bile acid metabolic process (GO:0008206)5.04131686
34regulation of cholesterol esterification (GO:0010872)4.99797009
35plasma lipoprotein particle remodeling (GO:0034369)4.95059078
36protein-lipid complex remodeling (GO:0034368)4.95059078
37macromolecular complex remodeling (GO:0034367)4.95059078
38aromatic amino acid family metabolic process (GO:0009072)4.88060593
39regulation of triglyceride catabolic process (GO:0010896)4.86238720
40homocysteine metabolic process (GO:0050667)4.83646800
41fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.80316558
42tyrosine metabolic process (GO:0006570)4.79831131
43positive regulation of heterotypic cell-cell adhesion (GO:0034116)4.69617032
44phospholipid efflux (GO:0033700)4.69397561
45triglyceride homeostasis (GO:0070328)4.66232808
46acylglycerol homeostasis (GO:0055090)4.66232808
47negative regulation of blood coagulation (GO:0030195)4.65910389
48negative regulation of hemostasis (GO:1900047)4.65910389
49amino-acid betaine metabolic process (GO:0006577)4.61607253
50alpha-amino acid catabolic process (GO:1901606)4.61204420
51regulation of humoral immune response (GO:0002920)4.60918128
52positive regulation of blood coagulation (GO:0030194)4.58055458
53positive regulation of hemostasis (GO:1900048)4.58055458
54negative regulation of sterol transport (GO:0032372)4.57485934
55negative regulation of cholesterol transport (GO:0032375)4.57485934
56plasma lipoprotein particle clearance (GO:0034381)4.56416140
57lysine metabolic process (GO:0006553)4.54500813
58lysine catabolic process (GO:0006554)4.54500813
59cellular ketone body metabolic process (GO:0046950)4.46404601
60acute-phase response (GO:0006953)4.45818525
61glycine metabolic process (GO:0006544)4.42528703
62cholesterol efflux (GO:0033344)4.38255735
63bile acid and bile salt transport (GO:0015721)4.37143343
64imidazole-containing compound metabolic process (GO:0052803)4.33068241
65negative regulation of coagulation (GO:0050819)4.28392694
66glutamate metabolic process (GO:0006536)4.26178416
67indolalkylamine metabolic process (GO:0006586)4.25820503
68cellular amino acid catabolic process (GO:0009063)4.24748928
69coenzyme catabolic process (GO:0009109)4.22531009
70plasma lipoprotein particle assembly (GO:0034377)4.21141719
71serine family amino acid metabolic process (GO:0009069)4.18008634
72low-density lipoprotein particle remodeling (GO:0034374)4.17668199
73positive regulation of coagulation (GO:0050820)4.17487022
74negative regulation of complement activation (GO:0045916)4.17072018
75cellular glucuronidation (GO:0052695)4.16720415
76amine catabolic process (GO:0009310)4.15699583
77cellular biogenic amine catabolic process (GO:0042402)4.15699583
78fibrinolysis (GO:0042730)4.15082770
79negative regulation of wound healing (GO:0061045)4.10937807
80epoxygenase P450 pathway (GO:0019373)4.08412635
81serine family amino acid biosynthetic process (GO:0009070)4.06923485
82cellular modified amino acid catabolic process (GO:0042219)4.06726649
83dicarboxylic acid biosynthetic process (GO:0043650)4.05910082
84lipoprotein metabolic process (GO:0042157)4.04500833
85benzene-containing compound metabolic process (GO:0042537)4.03529632
86blood coagulation, intrinsic pathway (GO:0007597)4.03134260
87ethanol oxidation (GO:0006069)4.02718718
88arginine metabolic process (GO:0006525)4.01609069
89aldehyde catabolic process (GO:0046185)3.99078849
90exogenous drug catabolic process (GO:0042738)3.93852833
91positive regulation of extracellular matrix organization (GO:1903055)3.90980176
92regulation of cholesterol biosynthetic process (GO:0045540)3.88591889
93phospholipid homeostasis (GO:0055091)3.88008781
94very-low-density lipoprotein particle assembly (GO:0034379)3.87538993
95ketone body metabolic process (GO:1902224)3.86274199
96drug catabolic process (GO:0042737)3.86099846
97positive regulation of lipoprotein lipase activity (GO:0051006)3.85981263
98positive regulation of triglyceride lipase activity (GO:0061365)3.85981263
99cholesterol transport (GO:0030301)3.83104754
100sterol transport (GO:0015918)3.83104754
101positive regulation of lipid catabolic process (GO:0050996)3.81720676
102intestinal absorption (GO:0050892)3.81231561
103cholesterol homeostasis (GO:0042632)3.80930358
104plasma lipoprotein particle organization (GO:0071827)3.79400636
105protein activation cascade (GO:0072376)3.78444875
106protein-lipid complex assembly (GO:0065005)3.77585284
107cofactor catabolic process (GO:0051187)3.76123951
108negative regulation of lipase activity (GO:0060192)3.75675413
109sterol homeostasis (GO:0055092)3.74556769
110complement activation, classical pathway (GO:0006958)3.74194071
111complement activation (GO:0006956)3.73363407
112organic acid catabolic process (GO:0016054)3.70913774
113carboxylic acid catabolic process (GO:0046395)3.70913774
114regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)3.69969264
115positive regulation of fatty acid biosynthetic process (GO:0045723)3.69942303
116glucuronate metabolic process (GO:0019585)3.69200571
117uronic acid metabolic process (GO:0006063)3.69200571
118regulation of bile acid biosynthetic process (GO:0070857)3.67430572
119proline metabolic process (GO:0006560)3.65175500
120negative regulation of protein activation cascade (GO:2000258)3.63849452
121short-chain fatty acid metabolic process (GO:0046459)3.61531187
122low-density lipoprotein particle clearance (GO:0034383)3.59188152
123regulation of cholesterol homeostasis (GO:2000188)3.58800289
124acetyl-CoA metabolic process (GO:0006084)3.56990656
125protein-lipid complex subunit organization (GO:0071825)3.56802776
126cytolysis (GO:0019835)3.55847781
127positive regulation of steroid metabolic process (GO:0045940)3.55713167
128diacylglycerol metabolic process (GO:0046339)3.52064007
129ethanol metabolic process (GO:0006067)3.51300258
130omega-hydroxylase P450 pathway (GO:0097267)3.40002032
131acute inflammatory response (GO:0002526)3.31635101
132peptidyl-glutamic acid modification (GO:0018200)3.28022076
133negative regulation of lipid transport (GO:0032369)3.23955850
134lipid homeostasis (GO:0055088)3.22809216
135negative regulation of humoral immune response (GO:0002921)3.21700201
136regulation of cholesterol metabolic process (GO:0090181)3.21015029
137embryonic retina morphogenesis in camera-type eye (GO:0060059)3.19101269

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* RXR_22158963_ChIP-Seq_LIVER_Mouse8.40208202
2* PPARA_22158963_ChIP-Seq_LIVER_Mouse7.19572967
3EGR1_23403033_ChIP-Seq_LIVER_Mouse7.01747460
4LXR_22158963_ChIP-Seq_LIVER_Mouse6.55474325
5FOXO1_23066095_ChIP-Seq_LIVER_Mouse5.28761345
6CEBPA_23403033_ChIP-Seq_LIVER_Mouse5.18392382
7PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.80750626
8CEBPB_23403033_ChIP-Seq_LIVER_Mouse4.04905952
9* NR1I2_20693526_ChIP-Seq_LIVER_Mouse4.00497210
10CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human2.35534596
11TCF7L2_21901280_ChIP-Seq_H4IIE_Rat2.09668007
12HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.01722289
13* ESR1_17901129_ChIP-ChIP_LIVER_Mouse12.0209191
14TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.94501324
15HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.94487949
16TCF4_18268006_ChIP-ChIP_LS174T_Human1.68437895
17* FOXA2_19822575_ChIP-Seq_HepG2_Human1.63788969
18AR_21909140_ChIP-Seq_LNCAP_Human1.60737681
19CLOCK_20551151_ChIP-Seq_293T_Human1.60314127
20GATA1_22025678_ChIP-Seq_K562_Human1.57866689
21PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.56934596
22HTT_18923047_ChIP-ChIP_STHdh_Human1.56178646
23TP63_17297297_ChIP-ChIP_HaCaT_Human1.44793949
24HIF1A_21447827_ChIP-Seq_MCF-7_Human1.42897592
25* HNF4A_19822575_ChIP-Seq_HepG2_Human1.41723036
26NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.34306426
27THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.31784612
28ESR1_15608294_ChIP-ChIP_MCF-7_Human1.22511668
29STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.19689046
30RXRA_24833708_ChIP-Seq_LIVER_Mouse1.19293234
31STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.17218494
32TRIM28_21343339_ChIP-Seq_HEK293_Human1.15670300
33IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.98191294
34ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.97300000
35NFIB_24661679_ChIP-Seq_LUNG_Mouse0.96342697
36TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.93565803
37SOX2_27498859_Chip-Seq_STOMACH_Mouse0.92797906
38FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.91126746
39PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.90571821
40POU5F1_16518401_ChIP-PET_MESCs_Mouse0.89200025
41CTNNB1_20460455_ChIP-Seq_HCT116_Human0.87861814
42PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.87409515
43AUTS2_25519132_ChIP-Seq_293T-REX_Human0.83584756
44ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.83378835
45IRF8_22096565_ChIP-ChIP_GC-B_Human0.83195103
46GATA4_25053715_ChIP-Seq_YYC3_Human0.83116262
47MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.82724701
48ZNF263_19887448_ChIP-Seq_K562_Human0.80787281
49BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.79941682
50SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.78729628
51RBPJ_22232070_ChIP-Seq_NCS_Mouse0.78238093
52ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.76501720
53ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.76396838
54POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.75344932
55SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.75026550
56GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.74718737
57RARA_24833708_ChIP-Seq_LIVER_Mouse0.74037608
58CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.73247185
59* RARG_19884340_ChIP-ChIP_MEFs_Mouse0.72941039
60KAP1_22055183_ChIP-Seq_ESCs_Mouse0.72603908
61CDX2_19796622_ChIP-Seq_MESCs_Mouse0.72570137
62Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.72370602
63AR_21572438_ChIP-Seq_LNCaP_Human0.72070782
64SALL4_18804426_ChIP-ChIP_XEN_Mouse0.71182326
65SOX17_20123909_ChIP-Seq_XEN_Mouse0.70268373
66AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.69234180
67EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.67073818
68ESR2_21235772_ChIP-Seq_MCF-7_Human0.66450783
69PCGF2_27294783_Chip-Seq_NPCs_Mouse0.66101264
70NRF2_20460467_ChIP-Seq_MEFs_Mouse0.65521509
71NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.65521509
72NANOG_21062744_ChIP-ChIP_HESCs_Human0.64544556
73FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.62177812
74NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.61884269
75SOX11_22085726_ChIP-Seq_ESNs_Mouse0.61875226
76TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.61586801
77NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.61479683
78* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.61236233
79DNAJC2_21179169_ChIP-ChIP_NT2_Human0.60470198
80RAD21_21589869_ChIP-Seq_MESCs_Mouse0.59955545
81* RARB_24833708_ChIP-Seq_LIVER_Mouse0.59494420
82BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.59005256
83NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.58925152
84CEBPB_22108803_ChIP-Seq_LS180_Human0.57442906
85* SMAD1_18555785_Chip-Seq_ESCs_Mouse0.57122383
86GATA1_19941826_ChIP-Seq_K562_Human0.55364032
87FOXA1_25552417_ChIP-Seq_VCAP_Human0.55232609
88RAC3_21632823_ChIP-Seq_H3396_Human0.55085481
89CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.54830680
90TP53_16413492_ChIP-PET_HCT116_Human0.54769816
91CSB_26484114_Chip-Seq_FIBROBLAST_Human0.54526796
92EGR1_19032775_ChIP-ChIP_M12_Human0.54449057
93NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse0.54365218
94PCGF2_27294783_Chip-Seq_ESCs_Mouse0.54322247
95FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.52621991
96LXR_22292898_ChIP-Seq_THP-1_Human0.52144455
97FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.51986914
98MYC_19915707_ChIP-ChIP_AK7_Human0.51380066
99STAT3_1855785_ChIP-Seq_MESCs_Mouse0.51294349
100SOX2_18358816_ChIP-ChIP_MESCs_Mouse0.50935769
101GATA1_19941827_ChIP-Seq_MEL_Mouse0.49170730
102* AR_20517297_ChIP-Seq_VCAP_Human0.49127405
103GATA3_24758297_ChIP-Seq_MCF-7_Human0.49061214
104PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.48755500
105SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.48173199
106SMC4_20622854_ChIP-Seq_HELA_Human0.48123566
107SOX2_21211035_ChIP-Seq_LN229_Human0.47540180
108ESET_19884257_ChIP-Seq_ESCs_Mouse0.47227686
109GATA2_19941826_ChIP-Seq_K562_Human0.46957053
110STAT1_17558387_ChIP-Seq_HELA_Human0.46702739
111ESR1_21235772_ChIP-Seq_MCF-7_Human0.46543723
112PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.46372432
113P53_21459846_ChIP-Seq_SAOS-2_Human0.46352026
114PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.45384464
115* CBP_21632823_ChIP-Seq_H3396_Human0.45095834
116TAF15_26573619_Chip-Seq_HEK293_Human0.44454653
117PPAR_26484153_Chip-Seq_NCI-H1993_Human0.43409739
118FOXO3_23340844_ChIP-Seq_DLD1_Human0.43106472
119TAF2_19829295_ChIP-Seq_ESCs_Human0.42107852
120PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.41966252
121CDX2_20551321_ChIP-Seq_CACO-2_Human0.41507263
122* FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.41379403
123ERG_21242973_ChIP-ChIP_JURKAT_Human0.39878933
124ESR1_20079471_ChIP-ChIP_T-47D_Human0.39531543
125E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.39194992
126SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.38803124
127CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.38765804
128* GATA6_25053715_ChIP-Seq_YYC3_Human0.38164847
129MYC_27129775_Chip-Seq_CORNEA_Mouse0.36981843
130BCAT_22108803_ChIP-Seq_LS180_Human0.36937598
131STAT3_19079543_ChIP-ChIP_MESCs_Mouse0.36927382
132FOXH1_21741376_ChIP-Seq_EPCs_Human0.34505350
133LUZP1_20508642_ChIP-Seq_ESCs_Mouse0.34460475
134ERG_20517297_ChIP-Seq_VCAP_Human0.34435851
135CDX2_22108803_ChIP-Seq_LS180_Human0.34102869
136SPI1_26923725_Chip-Seq_HPCs_Mouse0.33892785
137SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.33543264
138GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.32861835
139SOX2_20726797_ChIP-Seq_SW620_Human0.32422608

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system8.22510838
2MP0005360_urolithiasis7.52884081
3MP0005085_abnormal_gallbladder_physiolo6.43554166
4MP0005365_abnormal_bile_salt6.17477662
5MP0008875_abnormal_xenobiotic_pharmacok5.04611225
6MP0003806_abnormal_nucleotide_metabolis4.21847247
7MP0003122_maternal_imprinting3.95635495
8MP0003252_abnormal_bile_duct3.89453773
9MP0010329_abnormal_lipoprotein_level3.63903868
10MP0009840_abnormal_foam_cell3.31359349
11MP0005083_abnormal_biliary_tract3.23448651
12MP0003195_calcinosis2.85246135
13MP0005332_abnormal_amino_acid2.74026740
14MP0001666_abnormal_nutrient_absorption2.62837923
15MP0003191_abnormal_cellular_cholesterol2.41407668
16MP0000566_synostosis2.23561289
17MP0000609_abnormal_liver_physiology2.18681248
18MP0004019_abnormal_vitamin_homeostasis2.14114425
19MP0002118_abnormal_lipid_homeostasis2.09809453
20MP0003123_paternal_imprinting2.01783073
21MP0002138_abnormal_hepatobiliary_system1.98198493
22MP0003868_abnormal_feces_composition1.94771416
23MP0001915_intracranial_hemorrhage1.85284006
24MP0005319_abnormal_enzyme/_coenzyme1.81192656
25MP0002089_abnormal_postnatal_growth/wei1.79183408
26MP0001764_abnormal_homeostasis1.66963781
27MP0009697_abnormal_copulation1.64272040
28MP0005058_abnormal_lysosome_morphology1.57094483
29MP0005584_abnormal_enzyme/coenzyme_acti1.56442782
30MP0003656_abnormal_erythrocyte_physiolo1.47547529
31MP0003011_delayed_dark_adaptation1.46897759
32MP0003172_abnormal_lysosome_physiology1.44594686
33MP0005451_abnormal_body_composition1.39158679
34MP0003186_abnormal_redox_activity1.26391574
35MP0009643_abnormal_urine_homeostasis1.22561203
36MP0003705_abnormal_hypodermis_morpholog1.22298886
37MP0000598_abnormal_liver_morphology1.20429876
38MP0006054_spinal_hemorrhage1.19239677
39MP0003121_genomic_imprinting1.13226094
40MP0000604_amyloidosis1.13038109
41MP0005647_abnormal_sex_gland1.10783276
42MP0002254_reproductive_system_inflammat1.09474976
43MP0004272_abnormal_basement_membrane1.08777626
44MP0005409_darkened_coat_color1.06956329
45MP0009764_decreased_sensitivity_to1.04939101
46MP0009763_increased_sensitivity_to1.04489805
47MP0010368_abnormal_lymphatic_system1.01970738
48MP0009780_abnormal_chondrocyte_physiolo0.96421817
49MP0005636_abnormal_mineral_homeostasis0.96080759
50MP0005167_abnormal_blood-brain_barrier0.90352770
51MP0005257_abnormal_intraocular_pressure0.88923183
52MP0008469_abnormal_protein_level0.88609112
53MP0005408_hypopigmentation0.88429997
54MP0009642_abnormal_blood_homeostasis0.87357987
55MP0005084_abnormal_gallbladder_morpholo0.82103727
56MP0003950_abnormal_plasma_membrane0.82007372
57MP0005376_homeostasis/metabolism_phenot0.80606427
58MP0006036_abnormal_mitochondrial_physio0.79873243
59MP0009765_abnormal_xenobiotic_induced0.79383223
60MP0002078_abnormal_glucose_homeostasis0.77754512
61MP0005220_abnormal_exocrine_pancreas0.77304924
62MP0003567_abnormal_fetal_cardiomyocyte0.75821892
63MP0005670_abnormal_white_adipose0.72674618
64MP0002933_joint_inflammation0.72542378
65MP0001661_extended_life_span0.71601731
66MP0002971_abnormal_brown_adipose0.70795510
67MP0009053_abnormal_anal_canal0.70171238
68MP0002876_abnormal_thyroid_physiology0.69921795
69MP0004130_abnormal_muscle_cell0.69103350
70MP0003690_abnormal_glial_cell0.68687594
71MP0005334_abnormal_fat_pad0.67674953
72MP0003183_abnormal_peptide_metabolism0.67161080
73MP0003943_abnormal_hepatobiliary_system0.66507588
74MP0000639_abnormal_adrenal_gland0.64318552
75MP0005535_abnormal_body_temperature0.64186684
76MP0003329_amyloid_beta_deposits0.62420195
77MP0005266_abnormal_metabolism0.61964432
78MP0003879_abnormal_hair_cell0.61832512
79MP0000003_abnormal_adipose_tissue0.60994489
80MP0003632_abnormal_nervous_system0.60892900
81MP0005464_abnormal_platelet_physiology0.60767284
82MP0002282_abnormal_trachea_morphology0.60732288
83MP0003566_abnormal_cell_adhesion0.60396484
84MP0005076_abnormal_cell_differentiation0.59968673
85MP0004264_abnormal_extraembryonic_tissu0.59714202
86MP0001756_abnormal_urination0.59270270
87MP0003315_abnormal_perineum_morphology0.59126732
88MP0001270_distended_abdomen0.57617506
89MP0000920_abnormal_myelination0.57568437
90MP0003115_abnormal_respiratory_system0.57533181
91MP0003878_abnormal_ear_physiology0.56910401
92MP0005377_hearing/vestibular/ear_phenot0.56910401
93MP0005448_abnormal_energy_balance0.55957991
94MP0001324_abnormal_eye_pigmentation0.54701488
95MP0006035_abnormal_mitochondrial_morpho0.54619476
96MP0002909_abnormal_adrenal_gland0.54317707
97MP0003941_abnormal_skin_development0.53909875
98MP0005410_abnormal_fertilization0.53084862
99MP0002938_white_spotting0.52479130
100MP0005023_abnormal_wound_healing0.52265302
101MP0005395_other_phenotype0.50073603
102MP0003890_abnormal_embryonic-extraembry0.45929102
103MP0002928_abnormal_bile_duct0.45729760
104MP0003718_maternal_effect0.45431825
105MP0002136_abnormal_kidney_physiology0.44982933
106MP0003638_abnormal_response/metabolism_0.44874615
107MP0008873_increased_physiological_sensi0.44361381
108MP0002822_catalepsy0.43049506
109MP0008874_decreased_physiological_sensi0.42994616
110MP0003942_abnormal_urinary_system0.42565460
111MP0003436_decreased_susceptibility_to0.42491662
112MP0000858_altered_metastatic_potential0.42459150
113MP0003075_altered_response_to0.41366322
114MP0003724_increased_susceptibility_to0.40977835
115MP0005379_endocrine/exocrine_gland_phen0.40425355
116MP0003953_abnormal_hormone_level0.39810635
117MP0004782_abnormal_surfactant_physiolog0.39594434
118MP0002092_abnormal_eye_morphology0.39288092
119MP0002697_abnormal_eye_size0.39081386
120MP0002837_dystrophic_cardiac_calcinosis0.38887285
121MP0005248_abnormal_Harderian_gland0.37983680
122MP0004883_abnormal_blood_vessel0.37810126
123MP0009672_abnormal_birth_weight0.37533223
124MP0008872_abnormal_physiological_respon0.36971554
125MP0005166_decreased_susceptibility_to0.35969888
126MP0005666_abnormal_adipose_tissue0.35214830
127MP0001243_abnormal_dermal_layer0.34488944
128MP0000249_abnormal_blood_vessel0.33636230
129MP0009384_cardiac_valve_regurgitation0.32997924
130MP0002168_other_aberrant_phenotype0.31817588
131MP0009115_abnormal_fat_cell0.31792197
132MP0000579_abnormal_nail_morphology0.31680098
133MP0002796_impaired_skin_barrier0.31243051
134MP0004381_abnormal_hair_follicle0.30951482
135MP0001853_heart_inflammation0.30764464
136MP0000230_abnormal_systemic_arterial0.30009887
137MP0005164_abnormal_response_to0.29995629
138MP0002970_abnormal_white_adipose0.29316945
139MP0006082_CNS_inflammation0.28459565
140MP0001845_abnormal_inflammatory_respons0.28343945
141MP0001881_abnormal_mammary_gland0.27129505
142MP0002060_abnormal_skin_morphology0.26110694
143MP0002090_abnormal_vision0.24678062
144MP0002132_abnormal_respiratory_system0.24466766

Predicted human phenotypes

RankGene SetZ-score
1Deep venous thrombosis (HP:0002625)7.61351152
2Abnormality of aromatic amino acid family metabolism (HP:0004338)7.31035821
3Intrahepatic cholestasis (HP:0001406)7.28494249
4Prolonged partial thromboplastin time (HP:0003645)6.71520279
5Abnormality of monocarboxylic acid metabolism (HP:0010996)6.61593484
6Hypobetalipoproteinemia (HP:0003563)6.48463033
7Xanthomatosis (HP:0000991)6.33010482
8Hyperlipoproteinemia (HP:0010980)5.52710882
9Complement deficiency (HP:0004431)5.37402229
10Joint hemorrhage (HP:0005261)4.96181355
11Hypolipoproteinemia (HP:0010981)4.92155110
12Abnormality of the common coagulation pathway (HP:0010990)4.67034792
13Hyperammonemia (HP:0001987)4.59635973
14Epidermoid cyst (HP:0200040)4.50177750
15Abnormality of the level of lipoprotein cholesterol (HP:0010979)4.49469160
16Hyperglycinemia (HP:0002154)4.34930260
17Hypoalphalipoproteinemia (HP:0003233)4.32357537
18Abnormality of methionine metabolism (HP:0010901)4.27137117
19Abnormality of sulfur amino acid metabolism (HP:0004339)4.21311390
20Ketosis (HP:0001946)4.20746784
21Abnormality of glutamine family amino acid metabolism (HP:0010902)4.13282841
22Fat malabsorption (HP:0002630)4.11619710
23Abnormality of aspartate family amino acid metabolism (HP:0010899)4.09195862
24Abnormality of complement system (HP:0005339)3.92436393
25Hypoglycemic coma (HP:0001325)3.86709082
26Abnormality of the intrinsic pathway (HP:0010989)3.86644128
27Abnormality of glycine metabolism (HP:0010895)3.86369541
28Abnormality of serine family amino acid metabolism (HP:0010894)3.86369541
29Hyperglycinuria (HP:0003108)3.84580630
30Abnormality of pyrimidine metabolism (HP:0004353)3.80274412
31Conjugated hyperbilirubinemia (HP:0002908)3.71938407
32Hypercholesterolemia (HP:0003124)3.68573349
33Hyperbilirubinemia (HP:0002904)3.44288564
34Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.26364728
35Abnormality of fatty-acid metabolism (HP:0004359)3.24078181
36Spontaneous abortion (HP:0005268)3.22675175
37Hypochromic microcytic anemia (HP:0004840)3.16558825
38Purpura (HP:0000979)3.16077400
39Abnormality of carpal bone ossification (HP:0006257)3.09221668
40Hepatocellular carcinoma (HP:0001402)3.08516318
41Steatorrhea (HP:0002570)3.04089555
42Delayed CNS myelination (HP:0002188)3.03893701
43Abnormality of serum amino acid levels (HP:0003112)3.03125676
44Abnormality of nucleobase metabolism (HP:0010932)2.99953646
45Small epiphyses (HP:0010585)2.99582523
46Abnormal tarsal ossification (HP:0008369)2.98832494
47Ketoacidosis (HP:0001993)2.95980205
48Myocardial infarction (HP:0001658)2.94916857
49Acanthocytosis (HP:0001927)2.93096273
50Skin nodule (HP:0200036)2.80586405
51Metabolic acidosis (HP:0001942)2.73801716
52Flat acetabular roof (HP:0003180)2.71146079
53Systemic lupus erythematosus (HP:0002725)2.69255810
54Broad alveolar ridges (HP:0000187)2.60366145
55Glomerulonephritis (HP:0000099)2.60175269
56Abnormality of purine metabolism (HP:0004352)2.59793262
57Vascular calcification (HP:0004934)2.57159588
58Abnormal gallbladder morphology (HP:0012437)2.56364231
59Lethargy (HP:0001254)2.55429932
60Osteomalacia (HP:0002749)2.50785890
61Cholelithiasis (HP:0001081)2.50779436
62Hypoglycemic seizures (HP:0002173)2.50533125
63Abnormality of dicarboxylic acid metabolism (HP:0010995)2.50467384
64Dicarboxylic aciduria (HP:0003215)2.50467384
65Pancreatic islet-cell hyperplasia (HP:0004510)2.46353080
66Spastic diplegia (HP:0001264)2.44460365
67Abnormal gallbladder physiology (HP:0012438)2.42686985
68Cholecystitis (HP:0001082)2.42686985
69Arthropathy (HP:0003040)2.42224882
70Cerebral edema (HP:0002181)2.40127939
71Amyloidosis (HP:0011034)2.40055145
72Mitral stenosis (HP:0001718)2.39703532
73Gout (HP:0001997)2.38548647
74Gingival bleeding (HP:0000225)2.36280753
75Poikilocytosis (HP:0004447)2.34747723
76Recurrent gram-negative bacterial infections (HP:0005420)2.31760304
77Irritability (HP:0000737)2.31351524
78Cardiovascular calcification (HP:0011915)2.29792349
79Neonatal onset (HP:0003623)2.29133238
80Abnormal hand bone ossification (HP:0010660)2.28874866
81Esophageal varix (HP:0002040)2.27995563
82Broad palm (HP:0001169)2.27355628
83Abnormal ossification of hand bones (HP:0005921)2.27276254
84Increased serum pyruvate (HP:0003542)2.25687619
85Menorrhagia (HP:0000132)2.24661740
86Potter facies (HP:0002009)2.21003060
87Facial shape deformation (HP:0011334)2.21003060
88Thrombophlebitis (HP:0004418)2.19331682
89Malnutrition (HP:0004395)2.17620438
90Abnormality of the lumbar spine (HP:0100712)2.16606168
91Pancreatitis (HP:0001733)2.13558926
92Epiphyseal dysplasia (HP:0002656)2.13304004
93Asymmetry of the thorax (HP:0001555)2.13048282
94Hepatoblastoma (HP:0002884)2.12807372
95Enlarged kidneys (HP:0000105)2.12247542
96Sensorimotor neuropathy (HP:0007141)2.09158523
97Abnormality of glycolysis (HP:0004366)2.06827635
98Abnormality of the nasal septum (HP:0000419)2.06549182
99Abnormality of the gallbladder (HP:0005264)2.05540376
100Late onset (HP:0003584)2.04490699
101Brushfield spots (HP:0001088)2.04004898
102Vomiting (HP:0002013)2.03040214
103Hyperinsulinemic hypoglycemia (HP:0000825)2.02125189
104Hypoplasia of the capital femoral epiphysis (HP:0003090)2.01880524
105Hemorrhage of the eye (HP:0011885)2.01479371
106Vaginal fistula (HP:0004320)1.99236451
107Generalized aminoaciduria (HP:0002909)1.96435329
108Abnormality of the Achilles tendon (HP:0005109)1.96054535
109Opisthotonus (HP:0002179)1.95763445
110Abnormality of iron homeostasis (HP:0011031)1.94677540
111Rickets (HP:0002748)1.93071051
112Abnormality of transition element cation homeostasis (HP:0011030)1.92423416
113Abnormal foot bone ossification (HP:0010675)1.92148723
114Abnormal cartilage morphology (HP:0002763)1.88429509
115Diastasis recti (HP:0001540)1.86874239
116Nephritis (HP:0000123)1.84540607
117Alacrima (HP:0000522)1.84405987
118Bifid scrotum (HP:0000048)1.84264077
119Reticulocytosis (HP:0001923)1.84258055
120Hypophosphatemic rickets (HP:0004912)1.83792284
121Hydroxyprolinuria (HP:0003080)1.81205973
122Abnormality of proline metabolism (HP:0010907)1.81205973
123Renal cortical cysts (HP:0000803)1.79939551
124Elevated hepatic transaminases (HP:0002910)1.79793664
125Alkalosis (HP:0001948)1.79181042
126Abnormal enzyme/coenzyme activity (HP:0012379)1.78454371
127Abnormality of the wing of the ilium (HP:0011867)1.76511667
128Flared iliac wings (HP:0002869)1.74761070
129Status epilepticus (HP:0002133)1.74240956
130Abnormal delivery (HP:0001787)1.72986489
131Pulmonary embolism (HP:0002204)1.72414177
132Epistaxis (HP:0000421)1.71715228
133Peritonitis (HP:0002586)1.66910150
134Irregular epiphyses (HP:0010582)1.65870284
135Absent epiphyses (HP:0010577)1.65257222
136Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.65257222
137Abnormality of the acetabulum (HP:0003170)1.64827115
138Cupped ribs (HP:0000887)1.64560504
139Widely patent fontanelles and sutures (HP:0004492)1.64352267
140Submucous cleft hard palate (HP:0000176)1.63516088
141Neonatal death (HP:0003811)1.61686893
142Joint swelling (HP:0001386)1.61627373
143Abnormality of pain sensation (HP:0010832)1.60721624
144Impaired pain sensation (HP:0007328)1.60721624

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK7.13562969
2SIK14.58833790
3FGFR44.57568948
4ERN14.24100035
5WNK43.23318520
6CDK123.19096914
7INSRR3.09664547
8TAOK33.08058615
9ERBB42.84138837
10TYRO32.55007562
11PKN22.42554676
12FGFR12.30578375
13MAP2K42.30161031
14MST1R2.21584922
15FLT32.04211969
16MAPK111.95629348
17TRIB31.92808720
18AKT31.88408543
19PIK3CG1.88148631
20TYK21.74022295
21LATS11.73335335
22WNK11.61525989
23DAPK21.59268364
24EIF2AK11.52771575
25PTK61.50764019
26SIK21.49940512
27NEK91.49828285
28ABL21.48010537
29FRK1.45654278
30EEF2K1.43313043
31FGFR21.37158196
32KDR1.33711093
33MAP3K21.28903860
34JAK21.26012107
35PRKAA21.14373635
36MAP3K71.14289172
37DDR21.08847452
38GRK61.08001115
39ERBB21.06705844
40MAP2K31.05668438
41MAP3K101.05080271
42JAK11.04154977
43PINK11.03356781
44TBK10.98899857
45MAPK40.96593732
46MET0.96414584
47CDK70.94088239
48PRKCZ0.89482914
49MAPKAPK30.88591173
50MAP3K140.86249560
51MAP3K30.84914817
52EPHB10.84188873
53CDK60.83741807
54BRSK20.82625871
55FGR0.81570270
56MAPK120.81414356
57EPHA20.80943727
58EPHA30.80220972
59PRKACG0.78729996
60MAP3K110.77910556
61BRSK10.76891888
62RPS6KB10.76421453
63STK38L0.75448697
64CAMK1D0.75041427
65TIE10.74868943
66NEK10.74036114
67NTRK30.73668434
68SGK10.72895478
69SMG10.72049018
70MAPK150.71336594
71DYRK1B0.70654840
72STK390.68761321
73KSR20.68594095
74CSK0.67839440
75GSK3A0.67364204
76NEK20.67328720
77RIPK10.66821369
78CAMK2G0.66697848
79PRKAA10.66037634
80TGFBR20.65518432
81BCR0.63926688
82CDC42BPA0.61103336
83PTK20.59954454
84SGK30.59926629
85MAP2K60.59307735
86BRD40.59041365
87FGFR30.57822783
88CSF1R0.55698941
89* CSNK1E0.55212433
90MAPK70.55059263
91PDPK10.50343831
92IKBKE0.49242466
93PRKCQ0.49148884
94IRAK30.48269175
95MAP2K10.46759218
96CSNK1D0.46714303
97RET0.46573720
98TAOK20.46319461
99IGF1R0.45029210
100CSNK1G10.44557162
101MAP3K50.43902835
102GRK10.43840996
103CDK40.43830178
104CDK80.42588029
105PBK0.42201597
106SGK20.42092009
107PRKCG0.40527773
108SRC0.40339119
109CSNK2A20.39076094
110MTOR0.38996469
111EPHA40.38919674
112NTRK20.35468739
113RPS6KA30.35060725
114MAP3K60.34853438
115MATK0.34689559
116CSNK2A10.34297126
117EGFR0.33925180
118PKN10.33749639
119ICK0.33696951
120SCYL20.32692168
121PDK10.32404381
122MAP3K130.32082459
123PRKG10.29671276
124SGK2230.29601531
125SGK4940.29601531
126PDGFRB0.29572320
127YES10.29348684
128CAMK40.29206143
129CDK90.28526538
130MAP3K10.26671590
131MELK0.26092585
132PRKCA0.25853522
133PDGFRA0.24190601
134NLK0.24053093
135CSNK1G20.23806295
136LATS20.23472996
137BMX0.23413213
138CAMK1G0.23185630
139PAK30.22956056
140MAP2K20.22495768
141PIK3CA0.21332228
142STK30.20744383
143ABL10.20371635
144MAPK30.19213186

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001204.44910277
2Nitrogen metabolism_Homo sapiens_hsa009103.86862881
3Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.44100951
4Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.32773479
5Arginine biosynthesis_Homo sapiens_hsa002203.11396392
6Complement and coagulation cascades_Homo sapiens_hsa046102.87045720
7Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.67224588
8Tryptophan metabolism_Homo sapiens_hsa003802.64267628
9Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.63272244
10Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.56744756
11Fatty acid degradation_Homo sapiens_hsa000712.48680390
12Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.36793435
13Pentose and glucuronate interconversions_Homo sapiens_hsa000402.20808788
14Butanoate metabolism_Homo sapiens_hsa006502.13072594
15Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.09421466
16Peroxisome_Homo sapiens_hsa041462.02351835
17Propanoate metabolism_Homo sapiens_hsa006401.92340014
18Chemical carcinogenesis_Homo sapiens_hsa052041.91445593
19Histidine metabolism_Homo sapiens_hsa003401.88588018
20Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.88027989
21Steroid hormone biosynthesis_Homo sapiens_hsa001401.87812388
22PPAR signaling pathway_Homo sapiens_hsa033201.85085070
23Staphylococcus aureus infection_Homo sapiens_hsa051501.82773107
24Fatty acid metabolism_Homo sapiens_hsa012121.81095091
25Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.76994848
26Drug metabolism - other enzymes_Homo sapiens_hsa009831.72150372
27beta-Alanine metabolism_Homo sapiens_hsa004101.69815873
28Caffeine metabolism_Homo sapiens_hsa002321.65634439
29Retinol metabolism_Homo sapiens_hsa008301.65250977
30Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.62736155
31Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.62020315
32Selenocompound metabolism_Homo sapiens_hsa004501.59701955
33Phenylalanine metabolism_Homo sapiens_hsa003601.55920587
342-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.51144152
35Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.48921121
36Bile secretion_Homo sapiens_hsa049761.47762221
37Tyrosine metabolism_Homo sapiens_hsa003501.42522757
38Pyruvate metabolism_Homo sapiens_hsa006201.35070071
39Sulfur metabolism_Homo sapiens_hsa009201.33070466
40Cysteine and methionine metabolism_Homo sapiens_hsa002701.32573937
41Fatty acid elongation_Homo sapiens_hsa000621.31584507
42Starch and sucrose metabolism_Homo sapiens_hsa005001.27127977
43Steroid biosynthesis_Homo sapiens_hsa001001.23454991
44Biosynthesis of amino acids_Homo sapiens_hsa012301.22299246
45ABC transporters_Homo sapiens_hsa020101.21592545
46Fat digestion and absorption_Homo sapiens_hsa049751.21514305
47Folate biosynthesis_Homo sapiens_hsa007901.16947560
48Carbon metabolism_Homo sapiens_hsa012001.13681916
49Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.05589235
50Vitamin B6 metabolism_Homo sapiens_hsa007501.02534895
51Other glycan degradation_Homo sapiens_hsa005111.02049725
52Maturity onset diabetes of the young_Homo sapiens_hsa049500.99987423
53Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.99514943
54Cyanoamino acid metabolism_Homo sapiens_hsa004600.98196815
55Arginine and proline metabolism_Homo sapiens_hsa003300.96600681
56Sulfur relay system_Homo sapiens_hsa041220.92512156
57Vitamin digestion and absorption_Homo sapiens_hsa049770.89562009
58Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.86846571
59Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.84775062
60Lysine degradation_Homo sapiens_hsa003100.81263892
61One carbon pool by folate_Homo sapiens_hsa006700.79231440
62Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.70558833
63Glycerolipid metabolism_Homo sapiens_hsa005610.67309032
64Glutathione metabolism_Homo sapiens_hsa004800.63892224
65Pentose phosphate pathway_Homo sapiens_hsa000300.59022820
66N-Glycan biosynthesis_Homo sapiens_hsa005100.57527968
67Pertussis_Homo sapiens_hsa051330.55655962
68Fatty acid biosynthesis_Homo sapiens_hsa000610.55211936
69Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.46980482
70Metabolic pathways_Homo sapiens_hsa011000.45195979
71Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.35509399
72Prion diseases_Homo sapiens_hsa050200.33467858
73Galactose metabolism_Homo sapiens_hsa000520.25818648
74alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.24951094
75Insulin resistance_Homo sapiens_hsa049310.23418320
76Adipocytokine signaling pathway_Homo sapiens_hsa049200.22532744
77Fructose and mannose metabolism_Homo sapiens_hsa000510.22514424
78Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.20792396
79Linoleic acid metabolism_Homo sapiens_hsa005910.20786011
80Mineral absorption_Homo sapiens_hsa049780.15177084
81ECM-receptor interaction_Homo sapiens_hsa045120.14580174
82Glycerophospholipid metabolism_Homo sapiens_hsa005640.14576945
83Glucagon signaling pathway_Homo sapiens_hsa049220.09727460
84Sphingolipid metabolism_Homo sapiens_hsa006000.08201604
85AMPK signaling pathway_Homo sapiens_hsa041520.02223369
86Longevity regulating pathway - mammal_Homo sapiens_hsa04211-0.2426832
87Amoebiasis_Homo sapiens_hsa05146-0.2383396
88Bladder cancer_Homo sapiens_hsa05219-0.2372154
89Longevity regulating pathway - multiple species_Homo sapiens_hsa04213-0.2323786
90Carbohydrate digestion and absorption_Homo sapiens_hsa04973-0.2217112
91Thyroid hormone synthesis_Homo sapiens_hsa04918-0.1946743
92Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604-0.1813240
93Hepatitis C_Homo sapiens_hsa05160-0.1764970
94Arachidonic acid metabolism_Homo sapiens_hsa00590-0.1736073
95Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141-0.1675295
96Glycosaminoglycan degradation_Homo sapiens_hsa00531-0.1668964
97Renin-angiotensin system_Homo sapiens_hsa04614-0.1652839
98Regulation of autophagy_Homo sapiens_hsa04140-0.1607020
99Central carbon metabolism in cancer_Homo sapiens_hsa05230-0.1537364
100African trypanosomiasis_Homo sapiens_hsa05143-0.1409899
101Systemic lupus erythematosus_Homo sapiens_hsa05322-0.1006988
102Insulin signaling pathway_Homo sapiens_hsa04910-0.0980196
103Circadian rhythm_Homo sapiens_hsa04710-0.0890280
104Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534-0.0792022
105Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520-0.0749167
106Ovarian steroidogenesis_Homo sapiens_hsa04913-0.0733643
107HIF-1 signaling pathway_Homo sapiens_hsa04066-0.0693975
108Non-small cell lung cancer_Homo sapiens_hsa05223-0.0578183
109Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932-0.0574437
110Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550-0.0564894
111Other types of O-glycan biosynthesis_Homo sapiens_hsa00514-0.0311060

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