ITIH3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes the heavy chain subunit of the pre-alpha-trypsin inhibitor complex. This complex may stabilize the extracellular matrix through its ability to bind hyaluronic acid. Polymorphisms of this gene may be associated with increased risk for schizophrenia and major depressive disorder. This gene is present in an inter-alpha-trypsin inhibitor family gene cluster on chromosome 3. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)7.88045036
2L-phenylalanine catabolic process (GO:0006559)7.88045036
3erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)7.41510554
4L-phenylalanine metabolic process (GO:0006558)7.41510554
5aromatic amino acid family catabolic process (GO:0009074)6.73547792
6tryptophan catabolic process (GO:0006569)6.30021102
7indole-containing compound catabolic process (GO:0042436)6.30021102
8indolalkylamine catabolic process (GO:0046218)6.30021102
9kynurenine metabolic process (GO:0070189)6.20876997
10triglyceride-rich lipoprotein particle remodeling (GO:0034370)6.13983354
11regulation of protein activation cascade (GO:2000257)6.07017738
12exogenous drug catabolic process (GO:0042738)6.06785083
13tryptophan metabolic process (GO:0006568)5.90430197
14glyoxylate metabolic process (GO:0046487)5.89043647
15bile acid biosynthetic process (GO:0006699)5.78432365
16regulation of fibrinolysis (GO:0051917)5.69983427
17alpha-linolenic acid metabolic process (GO:0036109)5.66079361
18epoxygenase P450 pathway (GO:0019373)5.61940017
19negative regulation of fibrinolysis (GO:0051918)5.54676168
20complement activation, alternative pathway (GO:0006957)5.53486155
21regulation of complement activation (GO:0030449)5.53236908
22regulation of apoptotic cell clearance (GO:2000425)5.40756519
23protein carboxylation (GO:0018214)5.35598143
24peptidyl-glutamic acid carboxylation (GO:0017187)5.35598143
25urea cycle (GO:0000050)5.25397331
26urea metabolic process (GO:0019627)5.25397331
27high-density lipoprotein particle remodeling (GO:0034375)5.18023485
28omega-hydroxylase P450 pathway (GO:0097267)5.15737107
29fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)5.09743142
30cysteine metabolic process (GO:0006534)5.07551958
31imidazole-containing compound metabolic process (GO:0052803)4.90715692
32negative regulation of blood coagulation (GO:0030195)4.89383155
33negative regulation of hemostasis (GO:1900047)4.89383155
34bile acid metabolic process (GO:0008206)4.87963976
35regulation of humoral immune response (GO:0002920)4.86022474
36aromatic amino acid family metabolic process (GO:0009072)4.83114921
37nitrogen cycle metabolic process (GO:0071941)4.80645240
38glutamate metabolic process (GO:0006536)4.77045668
39reverse cholesterol transport (GO:0043691)4.74368236
40sulfur amino acid catabolic process (GO:0000098)4.73859050
41plasma lipoprotein particle remodeling (GO:0034369)4.71791617
42protein-lipid complex remodeling (GO:0034368)4.71791617
43macromolecular complex remodeling (GO:0034367)4.71791617
44positive regulation of blood coagulation (GO:0030194)4.70726422
45positive regulation of hemostasis (GO:1900048)4.70726422
46triglyceride homeostasis (GO:0070328)4.70206038
47acylglycerol homeostasis (GO:0055090)4.70206038
48regulation of triglyceride catabolic process (GO:0010896)4.69950079
49regulation of cholesterol esterification (GO:0010872)4.67043055
50serine family amino acid catabolic process (GO:0009071)4.65181716
51tyrosine metabolic process (GO:0006570)4.64819608
52coenzyme catabolic process (GO:0009109)4.62814407
53negative regulation of protein activation cascade (GO:2000258)4.58517295
54opsonization (GO:0008228)4.56187530
55positive regulation of heterotypic cell-cell adhesion (GO:0034116)4.55115388
56alpha-amino acid catabolic process (GO:1901606)4.53724928
57negative regulation of coagulation (GO:0050819)4.46862191
58homocysteine metabolic process (GO:0050667)4.44998242
59regulation of cholesterol homeostasis (GO:2000188)4.44487841
60indolalkylamine metabolic process (GO:0006586)4.43130479
61cellular biogenic amine catabolic process (GO:0042402)4.37039768
62amine catabolic process (GO:0009310)4.37039768
63negative regulation of wound healing (GO:0061045)4.33701608
64phospholipid efflux (GO:0033700)4.32255170
65cellular modified amino acid catabolic process (GO:0042219)4.31221774
66positive regulation of coagulation (GO:0050820)4.30672104
67lysine catabolic process (GO:0006554)4.28565356
68lysine metabolic process (GO:0006553)4.28565356
69negative regulation of complement activation (GO:0045916)4.27928837
70negative regulation of sterol transport (GO:0032372)4.25583501
71negative regulation of cholesterol transport (GO:0032375)4.25583501
72cholesterol efflux (GO:0033344)4.23719825
73amino-acid betaine metabolic process (GO:0006577)4.23522959
74glucuronate metabolic process (GO:0019585)4.18093482
75uronic acid metabolic process (GO:0006063)4.18093482
76dicarboxylic acid biosynthetic process (GO:0043650)4.10777993
77cellular amino acid catabolic process (GO:0009063)4.10424683
78negative regulation of lipase activity (GO:0060192)4.10124533
79plasma lipoprotein particle clearance (GO:0034381)4.09528344
80regulation of bile acid biosynthetic process (GO:0070857)4.08783182
81complement activation, classical pathway (GO:0006958)4.06441316
82low-density lipoprotein particle remodeling (GO:0034374)4.05915942
83plasma lipoprotein particle assembly (GO:0034377)4.04286939
84fibrinolysis (GO:0042730)4.02960719
85blood coagulation, intrinsic pathway (GO:0007597)4.02833570
86protein activation cascade (GO:0072376)4.02508904
87glycine metabolic process (GO:0006544)4.01358326
88bile acid and bile salt transport (GO:0015721)4.00877132
89acute-phase response (GO:0006953)3.99193256
90benzene-containing compound metabolic process (GO:0042537)3.98305542
91drug metabolic process (GO:0017144)3.95553510
92ethanol metabolic process (GO:0006067)3.94762593
93complement activation (GO:0006956)3.93951947
94cellular ketone body metabolic process (GO:0046950)3.93721552
95serine family amino acid metabolic process (GO:0009069)3.87016485
96very-low-density lipoprotein particle assembly (GO:0034379)3.86809797
97serine family amino acid biosynthetic process (GO:0009070)3.84626401
98cofactor catabolic process (GO:0051187)3.83290184
99ethanol oxidation (GO:0006069)3.82117320
100lipoprotein metabolic process (GO:0042157)3.80219897
101aldehyde catabolic process (GO:0046185)3.77401185
102phospholipid homeostasis (GO:0055091)3.76001530
103arginine metabolic process (GO:0006525)3.75935178
104plasma lipoprotein particle organization (GO:0071827)3.74162782
105positive regulation of lipoprotein lipase activity (GO:0051006)3.68891139
106positive regulation of triglyceride lipase activity (GO:0061365)3.68891139
107regulation of plasminogen activation (GO:0010755)3.67041135
108oxidative demethylation (GO:0070989)3.66661004
109drug catabolic process (GO:0042737)3.64871741
110cholesterol homeostasis (GO:0042632)3.64107867
111urate metabolic process (GO:0046415)3.63607933
112protein-lipid complex assembly (GO:0065005)3.61979390
113intestinal absorption (GO:0050892)3.61915576
114acetyl-CoA metabolic process (GO:0006084)3.60257721
115positive regulation of fatty acid biosynthetic process (GO:0045723)3.59316669
116disruption of cells of other organism involved in symbiotic interaction (GO:0051818)3.58578276
117killing of cells in other organism involved in symbiotic interaction (GO:0051883)3.58578276
118cellular glucuronidation (GO:0052695)3.57758055
119sterol homeostasis (GO:0055092)3.57651085
120cholesterol transport (GO:0030301)3.56301482
121sterol transport (GO:0015918)3.56301482
122acute inflammatory response (GO:0002526)3.55271727
123cytolysis (GO:0019835)3.54834921
124protein-lipid complex subunit organization (GO:0071825)3.51540603
125intestinal cholesterol absorption (GO:0030299)3.50669241
126organic acid catabolic process (GO:0016054)3.50541286
127proline metabolic process (GO:0006560)3.50441471
128phenylpropanoid metabolic process (GO:0009698)3.40435816
129peptidyl-glutamic acid modification (GO:0018200)3.39825154
130positive regulation of extracellular matrix organization (GO:1903055)3.39746114
131regulation of cholesterol biosynthetic process (GO:0045540)3.35033858
132negative regulation of humoral immune response (GO:0002921)3.34021838

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* RXR_22158963_ChIP-Seq_LIVER_Mouse8.14696646
2* PPARA_22158963_ChIP-Seq_LIVER_Mouse7.03155098
3EGR1_23403033_ChIP-Seq_LIVER_Mouse6.58043478
4* LXR_22158963_ChIP-Seq_LIVER_Mouse6.39822921
5FOXO1_23066095_ChIP-Seq_LIVER_Mouse5.46886706
6CEBPA_23403033_ChIP-Seq_LIVER_Mouse4.82409493
7PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.25230164
8NR1I2_20693526_ChIP-Seq_LIVER_Mouse4.14168978
9* CEBPB_23403033_ChIP-Seq_LIVER_Mouse3.69373992
10ESR1_17901129_ChIP-ChIP_LIVER_Mouse12.0231955
11TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.90521426
12HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.75720618
13FOXA2_19822575_ChIP-Seq_HepG2_Human1.72224231
14TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.68590506
15HTT_18923047_ChIP-ChIP_STHdh_Human1.53415856
16CLOCK_20551151_ChIP-Seq_293T_Human1.47466944
17ESR1_15608294_ChIP-ChIP_MCF-7_Human1.45410609
18GATA1_22025678_ChIP-Seq_K562_Human1.41273232
19* THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.38903851
20* HNF4A_19822575_ChIP-Seq_HepG2_Human1.38566252
21TCF4_18268006_ChIP-ChIP_LS174T_Human1.32484928
22TRIM28_21343339_ChIP-Seq_HEK293_Human1.19005492
23RXRA_24833708_ChIP-Seq_LIVER_Mouse1.14659622
24STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.12787633
25GATA6_25053715_ChIP-Seq_YYC3_Human1.08892861
26HIF1A_21447827_ChIP-Seq_MCF-7_Human1.05014548
27PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.02953698
28STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.02871633
29ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.02331166
30HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.00350663
31PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.98044909
32ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.93681699
33SOX2_27498859_Chip-Seq_STOMACH_Mouse0.93164661
34BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.93015542
35RARG_19884340_ChIP-ChIP_MEFs_Mouse0.92671441
36TP63_17297297_ChIP-ChIP_HaCaT_Human0.89808659
37IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.87000232
38ESR2_21235772_ChIP-Seq_MCF-7_Human0.84535319
39FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.83491353
40PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.82663728
41SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.78347399
42NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.76298401
43GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.76047796
44AR_21909140_ChIP-Seq_LNCAP_Human0.74230218
45AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.74097921
46ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.73386825
47SOX2_20726797_ChIP-Seq_SW620_Human0.72958180
48* AUTS2_25519132_ChIP-Seq_293T-REX_Human0.72544598
49MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.71708773
50RARA_24833708_ChIP-Seq_LIVER_Mouse0.70926371
51SALL4_18804426_ChIP-ChIP_XEN_Mouse0.70271287
52CDX2_19796622_ChIP-Seq_MESCs_Mouse0.69285417
53* POU5F1_16518401_ChIP-PET_MESCs_Mouse0.68546229
54GATA4_25053715_ChIP-Seq_YYC3_Human0.67600730
55* LXR_22292898_ChIP-Seq_THP-1_Human0.67590527
56NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.66638345
57NRF2_20460467_ChIP-Seq_MEFs_Mouse0.66638345
58SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.65558255
59CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.65429495
60PCGF2_27294783_Chip-Seq_NPCs_Mouse0.64916695
61CTNNB1_20460455_ChIP-Seq_HCT116_Human0.63870138
62IRF8_22096565_ChIP-ChIP_GC-B_Human0.63448162
63TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.61419859
64NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.61037935
65Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.60215016
66SMC4_20622854_ChIP-Seq_HELA_Human0.59288521
67RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.58995765
68KAP1_22055183_ChIP-Seq_ESCs_Mouse0.58985483
69RAD21_21589869_ChIP-Seq_MESCs_Mouse0.58833377
70SOX2_21211035_ChIP-Seq_LN229_Human0.58474037
71GATA1_19941826_ChIP-Seq_K562_Human0.58152811
72RARB_24833708_ChIP-Seq_LIVER_Mouse0.57868497
73ZNF263_19887448_ChIP-Seq_K562_Human0.57716636
74NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse0.57264028
75MYC_19915707_ChIP-ChIP_AK7_Human0.57181209
76PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.57055543
77FOXA1_25552417_ChIP-Seq_VCAP_Human0.56631170
78NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.56558904
79CSB_26484114_Chip-Seq_FIBROBLAST_Human0.56506943
80ERG_21242973_ChIP-ChIP_JURKAT_Human0.56342256
81ESR1_20079471_ChIP-ChIP_T-47D_Human0.55666524
82* RAC3_21632823_ChIP-Seq_H3396_Human0.55324951
83SMAD1_18555785_Chip-Seq_ESCs_Mouse0.55277866
84SOX11_22085726_ChIP-Seq_ESNs_Mouse0.54786484
85NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.54358649
86CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.54029141
87* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.52896185
88BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.52294694
89FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.49794926
90NFE2_27457419_Chip-Seq_LIVER_Mouse0.49738157
91STAT3_1855785_ChIP-Seq_MESCs_Mouse0.49429958
92CEBPB_22108803_ChIP-Seq_LS180_Human0.49377667
93ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.49055033
94* FOXO3_23340844_ChIP-Seq_DLD1_Human0.48587731
95TP53_16413492_ChIP-PET_HCT116_Human0.48568576
96SPI1_26923725_Chip-Seq_HPCs_Mouse0.48508107
97TAF15_26573619_Chip-Seq_HEK293_Human0.48344496
98ESRRB_18555785_Chip-Seq_ESCs_Mouse0.47840933
99POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.47510122
100BCAT_22108803_ChIP-Seq_LS180_Human0.47403253
101EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.46701767
102* MYC_27129775_Chip-Seq_CORNEA_Mouse0.46520776
103CBP_21632823_ChIP-Seq_H3396_Human0.46355688
104PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.46307097
105TAF2_19829295_ChIP-Seq_ESCs_Human0.46275973
106AR_20517297_ChIP-Seq_VCAP_Human0.46266530
107IRF1_19129219_ChIP-ChIP_H3396_Human0.45560485
108JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse0.45176628
109CDX2_20551321_ChIP-Seq_CACO-2_Human0.44388887
110EGR1_19032775_ChIP-ChIP_M12_Human0.44241084
111FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.44186202
112STAT3_19079543_ChIP-ChIP_MESCs_Mouse0.44012469
113ESR1_21235772_ChIP-Seq_MCF-7_Human0.43446632
114GATA2_19941826_ChIP-Seq_K562_Human0.42957699
115GATA1_19941827_ChIP-Seq_MEL_Mouse0.42164694
116CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.41812972
117NFIB_24661679_ChIP-Seq_LUNG_Mouse0.41705788
118* P53_21459846_ChIP-Seq_SAOS-2_Human0.41542525
119DNAJC2_21179169_ChIP-ChIP_NT2_Human0.41273259
120ESET_19884257_ChIP-Seq_ESCs_Mouse0.40381020
121ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.40057194
122CTCF_27219007_Chip-Seq_Bcells_Human0.38769663
123OCT4_20526341_ChIP-Seq_ESCs_Human0.38376008
124SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.38284582
125FOXH1_21741376_ChIP-Seq_EPCs_Human0.38250839
126PPAR_26484153_Chip-Seq_NCI-H1993_Human0.38047631
127SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.37868150
128CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.37463664
129PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.37105634
130TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.37055859
131PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.37046442
132GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.36293995
133FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.35428027

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system7.82420873
2MP0005360_urolithiasis6.92419977
3MP0005085_abnormal_gallbladder_physiolo6.45884193
4MP0005365_abnormal_bile_salt5.89741384
5MP0008875_abnormal_xenobiotic_pharmacok4.90280066
6MP0003806_abnormal_nucleotide_metabolis4.46403723
7MP0003252_abnormal_bile_duct4.02860229
8MP0010329_abnormal_lipoprotein_level3.73379282
9MP0005083_abnormal_biliary_tract3.45957609
10MP0003195_calcinosis3.20371839
11MP0009840_abnormal_foam_cell3.19770696
12MP0003122_maternal_imprinting2.80661540
13MP0005332_abnormal_amino_acid2.74749596
14MP0001666_abnormal_nutrient_absorption2.69064324
15MP0003191_abnormal_cellular_cholesterol2.68478837
16MP0000609_abnormal_liver_physiology2.27025930
17MP0002118_abnormal_lipid_homeostasis2.22442014
18MP0004019_abnormal_vitamin_homeostasis1.97843720
19MP0002138_abnormal_hepatobiliary_system1.81574340
20MP0005319_abnormal_enzyme/_coenzyme1.79070281
21MP0000566_synostosis1.64621654
22MP0001915_intracranial_hemorrhage1.60292560
23MP0003868_abnormal_feces_composition1.59579950
24MP0005584_abnormal_enzyme/coenzyme_acti1.56810890
25MP0002254_reproductive_system_inflammat1.56036084
26MP0010368_abnormal_lymphatic_system1.55472051
27MP0003656_abnormal_erythrocyte_physiolo1.46403079
28MP0005451_abnormal_body_composition1.42505977
29MP0001764_abnormal_homeostasis1.39022871
30MP0003011_delayed_dark_adaptation1.36976464
31MP0000604_amyloidosis1.33854393
32MP0002089_abnormal_postnatal_growth/wei1.26404119
33MP0009697_abnormal_copulation1.26087018
34MP0005647_abnormal_sex_gland1.24444292
35MP0005058_abnormal_lysosome_morphology1.22700368
36MP0000598_abnormal_liver_morphology1.21194831
37MP0003123_paternal_imprinting1.20534317
38MP0003705_abnormal_hypodermis_morpholog1.19353453
39MP0003172_abnormal_lysosome_physiology1.11701086
40MP0009643_abnormal_urine_homeostasis1.10575020
41MP0009763_increased_sensitivity_to1.09379912
42MP0009764_decreased_sensitivity_to1.06844323
43MP0003690_abnormal_glial_cell1.02751711
44MP0005084_abnormal_gallbladder_morpholo0.97037076
45MP0009384_cardiac_valve_regurgitation0.96359040
46MP0005636_abnormal_mineral_homeostasis0.94447438
47MP0003186_abnormal_redox_activity0.94379475
48MP0002971_abnormal_brown_adipose0.92500049
49MP0009642_abnormal_blood_homeostasis0.90048045
50MP0003329_amyloid_beta_deposits0.89171952
51MP0008469_abnormal_protein_level0.88784783
52MP0009379_abnormal_foot_pigmentation0.84937569
53MP0005409_darkened_coat_color0.82749499
54MP0005220_abnormal_exocrine_pancreas0.81344258
55MP0002078_abnormal_glucose_homeostasis0.81135613
56MP0003724_increased_susceptibility_to0.79917637
57MP0009765_abnormal_xenobiotic_induced0.75797881
58MP0005376_homeostasis/metabolism_phenot0.74921809
59MP0005334_abnormal_fat_pad0.74066225
60MP0002282_abnormal_trachea_morphology0.73690055
61MP0003879_abnormal_hair_cell0.73086624
62MP0005670_abnormal_white_adipose0.72201820
63MP0005535_abnormal_body_temperature0.71103212
64MP0004272_abnormal_basement_membrane0.70273092
65MP0002876_abnormal_thyroid_physiology0.68570704
66MP0005464_abnormal_platelet_physiology0.67460385
67MP0003075_altered_response_to0.67249197
68MP0001661_extended_life_span0.66627488
69MP0005408_hypopigmentation0.66122810
70MP0006036_abnormal_mitochondrial_physio0.64954372
71MP0000579_abnormal_nail_morphology0.64926979
72MP0004130_abnormal_muscle_cell0.64636411
73MP0005266_abnormal_metabolism0.64051596
74MP0009780_abnormal_chondrocyte_physiolo0.63677904
75MP0005257_abnormal_intraocular_pressure0.63192827
76MP0005166_decreased_susceptibility_to0.62699154
77MP0006054_spinal_hemorrhage0.62389138
78MP0000639_abnormal_adrenal_gland0.61452007
79MP0005448_abnormal_energy_balance0.57829406
80MP0003121_genomic_imprinting0.56530620
81MP0003436_decreased_susceptibility_to0.56299790
82MP0006035_abnormal_mitochondrial_morpho0.56145916
83MP0004883_abnormal_blood_vessel0.54112231
84MP0002928_abnormal_bile_duct0.53372980
85MP0001756_abnormal_urination0.52161086
86MP0008874_decreased_physiological_sensi0.51614002
87MP0002933_joint_inflammation0.51142683
88MP0003183_abnormal_peptide_metabolism0.51116374
89MP0005023_abnormal_wound_healing0.50978695
90MP0002837_dystrophic_cardiac_calcinosis0.50642988
91MP0003638_abnormal_response/metabolism_0.50423425
92MP0002822_catalepsy0.49518758
93MP0003567_abnormal_fetal_cardiomyocyte0.49127920
94MP0005395_other_phenotype0.47956178
95MP0009053_abnormal_anal_canal0.47213425
96MP0006082_CNS_inflammation0.45986262
97MP0002249_abnormal_larynx_morphology0.45755218
98MP0003878_abnormal_ear_physiology0.44965372
99MP0005377_hearing/vestibular/ear_phenot0.44965372
100MP0000920_abnormal_myelination0.44924895
101MP0003632_abnormal_nervous_system0.44754896
102MP0002136_abnormal_kidney_physiology0.44473769
103MP0003953_abnormal_hormone_level0.44160624
104MP0002909_abnormal_adrenal_gland0.43094428
105MP0003566_abnormal_cell_adhesion0.41299454
106MP0000003_abnormal_adipose_tissue0.40853542
107MP0003950_abnormal_plasma_membrane0.40546324
108MP0002132_abnormal_respiratory_system0.40170657
109MP0005167_abnormal_blood-brain_barrier0.40096784
110MP0008873_increased_physiological_sensi0.37571771
111MP0001881_abnormal_mammary_gland0.36135821
112MP0001324_abnormal_eye_pigmentation0.35629532
113MP0005410_abnormal_fertilization0.34866370
114MP0000230_abnormal_systemic_arterial0.34085332
115MP0003718_maternal_effect0.33822091
116MP0000249_abnormal_blood_vessel0.33645613
117MP0003943_abnormal_hepatobiliary_system0.33473682
118MP0008872_abnormal_physiological_respon0.33401162
119MP0002128_abnormal_blood_circulation0.33155263
120MP0003115_abnormal_respiratory_system0.32952504
121MP0004264_abnormal_extraembryonic_tissu0.32629902
122MP0002168_other_aberrant_phenotype0.31465010
123MP0002092_abnormal_eye_morphology0.31040044
124MP0002970_abnormal_white_adipose0.30635811
125MP0001270_distended_abdomen0.30567979
126MP0005666_abnormal_adipose_tissue0.29436877
127MP0003631_nervous_system_phenotype0.29387542
128MP0002796_impaired_skin_barrier0.29317802
129MP0001944_abnormal_pancreas_morphology0.28395649
130MP0002295_abnormal_pulmonary_circulatio0.28325919
131MP0005248_abnormal_Harderian_gland0.28207520
132MP0009115_abnormal_fat_cell0.27414067
133MP0004381_abnormal_hair_follicle0.27253094
134MP0005595_abnormal_vascular_smooth0.26807652
135MP0005164_abnormal_response_to0.26661435
136MP0001243_abnormal_dermal_layer0.26417863
137MP0003633_abnormal_nervous_system0.26220169

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of aromatic amino acid family metabolism (HP:0004338)7.31435453
2Deep venous thrombosis (HP:0002625)7.16807763
3Intrahepatic cholestasis (HP:0001406)7.13824070
4Prolonged partial thromboplastin time (HP:0003645)6.96224349
5Abnormality of monocarboxylic acid metabolism (HP:0010996)6.40308888
6Xanthomatosis (HP:0000991)6.39793348
7Hypobetalipoproteinemia (HP:0003563)5.89764335
8Complement deficiency (HP:0004431)5.78175012
9Hyperlipoproteinemia (HP:0010980)5.56051536
10Abnormality of the common coagulation pathway (HP:0010990)5.31913560
11Spontaneous abortion (HP:0005268)4.95734002
12Joint hemorrhage (HP:0005261)4.85399142
13Hypolipoproteinemia (HP:0010981)4.65951177
14Epidermoid cyst (HP:0200040)4.64986061
15Hypoalphalipoproteinemia (HP:0003233)4.44836618
16Abnormality of the level of lipoprotein cholesterol (HP:0010979)4.25105680
17Abnormality of complement system (HP:0005339)4.21362445
18Hyperammonemia (HP:0001987)4.10352082
19Hyperglycinemia (HP:0002154)4.06626902
20Abnormality of the intrinsic pathway (HP:0010989)3.98774495
21Ketosis (HP:0001946)3.98314445
22Abnormality of sulfur amino acid metabolism (HP:0004339)3.97657690
23Abnormality of methionine metabolism (HP:0010901)3.95090558
24Fat malabsorption (HP:0002630)3.95083187
25Hypoglycemic coma (HP:0001325)3.77751065
26Abnormality of aspartate family amino acid metabolism (HP:0010899)3.76162071
27Abnormality of glutamine family amino acid metabolism (HP:0010902)3.73723765
28Myocardial infarction (HP:0001658)3.72915197
29Conjugated hyperbilirubinemia (HP:0002908)3.70695295
30Abnormality of serine family amino acid metabolism (HP:0010894)3.63408216
31Abnormality of glycine metabolism (HP:0010895)3.63408216
32Hypercholesterolemia (HP:0003124)3.55846848
33Hyperglycinuria (HP:0003108)3.46362167
34Amyloidosis (HP:0011034)3.20990054
35Purpura (HP:0000979)3.19377927
36Hyperbilirubinemia (HP:0002904)3.15723977
37Abnormality of pyrimidine metabolism (HP:0004353)3.14524048
38Mitral stenosis (HP:0001718)3.11851294
39Gingival bleeding (HP:0000225)3.09550590
40Systemic lupus erythematosus (HP:0002725)3.04389610
41Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.95529690
42Vascular calcification (HP:0004934)2.93394861
43Ketoacidosis (HP:0001993)2.92449603
44Steatorrhea (HP:0002570)2.92183626
45Skin nodule (HP:0200036)2.91876754
46Hepatocellular carcinoma (HP:0001402)2.88944681
47Hypochromic microcytic anemia (HP:0004840)2.88309387
48Abnormality of fatty-acid metabolism (HP:0004359)2.85379060
49Hypoglycemic seizures (HP:0002173)2.75272584
50Delayed CNS myelination (HP:0002188)2.73602575
51Abnormality of nucleobase metabolism (HP:0010932)2.67369744
52Thrombophlebitis (HP:0004418)2.66476942
53Malnutrition (HP:0004395)2.63311145
54Gout (HP:0001997)2.62688387
55Cardiovascular calcification (HP:0011915)2.60887514
56Abnormality of serum amino acid levels (HP:0003112)2.58960453
57Abnormal gallbladder morphology (HP:0012437)2.56980444
58Glomerulonephritis (HP:0000099)2.56902707
59Cholelithiasis (HP:0001081)2.54638554
60Osteomalacia (HP:0002749)2.53850307
61Acanthocytosis (HP:0001927)2.53218423
62Hemorrhage of the eye (HP:0011885)2.50527482
63Abnormal tarsal ossification (HP:0008369)2.45512745
64Abnormality of purine metabolism (HP:0004352)2.43792592
65Metabolic acidosis (HP:0001942)2.41268795
66Abnormality of carpal bone ossification (HP:0006257)2.41031033
67Generalized aminoaciduria (HP:0002909)2.40220052
68Arthropathy (HP:0003040)2.32358635
69Sensorimotor neuropathy (HP:0007141)2.30362896
70Hypophosphatemic rickets (HP:0004912)2.29686846
71Hyperinsulinemic hypoglycemia (HP:0000825)2.27870118
72Cholecystitis (HP:0001082)2.27113487
73Abnormal gallbladder physiology (HP:0012438)2.27113487
74Recurrent gram-negative bacterial infections (HP:0005420)2.25647363
75Spastic diplegia (HP:0001264)2.24334666
76Late onset (HP:0003584)2.24057175
77Abnormality of iron homeostasis (HP:0011031)2.24047447
78Pulmonary embolism (HP:0002204)2.22560789
79Neonatal onset (HP:0003623)2.19779171
80Esophageal varix (HP:0002040)2.19173698
81Irritability (HP:0000737)2.18990050
82Enlarged kidneys (HP:0000105)2.17701337
83Lethargy (HP:0001254)2.17030775
84Abnormality of transition element cation homeostasis (HP:0011030)2.16819010
85Poikilocytosis (HP:0004447)2.13451199
86Abnormality of dicarboxylic acid metabolism (HP:0010995)2.08368521
87Dicarboxylic aciduria (HP:0003215)2.08368521
88Menorrhagia (HP:0000132)2.08352949
89Increased serum pyruvate (HP:0003542)2.06084405
90Abnormality of the gallbladder (HP:0005264)2.02811256
91Brushfield spots (HP:0001088)2.01350487
92Small epiphyses (HP:0010585)1.99785074
93Rickets (HP:0002748)1.98833333
94Flat acetabular roof (HP:0003180)1.98313185
95Opisthotonus (HP:0002179)1.96132754
96Abnormality of the Achilles tendon (HP:0005109)1.96124142
97Joint swelling (HP:0001386)1.94783162
98Cerebral edema (HP:0002181)1.92777877
99Broad alveolar ridges (HP:0000187)1.91749114
100Pancreatitis (HP:0001733)1.91020992
101Bifid scrotum (HP:0000048)1.90784669
102Epistaxis (HP:0000421)1.89129533
103Vaginal fistula (HP:0004320)1.88894758
104Abnormality of proline metabolism (HP:0010907)1.87964632
105Status epilepticus (HP:0002133)1.87949821
106Vomiting (HP:0002013)1.87889008
107Potter facies (HP:0002009)1.87333996
108Facial shape deformation (HP:0011334)1.87333996
109Pancreatic islet-cell hyperplasia (HP:0004510)1.86241319
110Asymmetry of the thorax (HP:0001555)1.85762749
111Abnormality of glycolysis (HP:0004366)1.84644624
112Confusion (HP:0001289)1.84157996
113Reticulocytosis (HP:0001923)1.81513190
114Spastic paraparesis (HP:0002313)1.81190392
115Increased serum ferritin (HP:0003281)1.81001153
116Symptomatic seizures (HP:0011145)1.80374828
117Elevated hepatic transaminases (HP:0002910)1.79873762
118Abnormal hand bone ossification (HP:0010660)1.76969370
119Stroke (HP:0001297)1.76263010
120Nephritis (HP:0000123)1.76126873
121Abnormal ossification of hand bones (HP:0005921)1.74394426
122Hyperglycemia (HP:0003074)1.73528710
123Hydroxyprolinuria (HP:0003080)1.71821104
124Abnormal delivery (HP:0001787)1.71177132
125Abnormality of the lumbar spine (HP:0100712)1.68910317
126Gangrene (HP:0100758)1.66819999
127Reduced antithrombin III activity (HP:0001976)1.58874471
128Peritonitis (HP:0002586)1.58320522
129Abnormality of the nasal septum (HP:0000419)1.56293360
130Fair hair (HP:0002286)1.56100298
131Hepatoblastoma (HP:0002884)1.55810188
132Abnormal foot bone ossification (HP:0010675)1.51509880
133Submucous cleft hard palate (HP:0000176)1.50626614
134Broad palm (HP:0001169)1.48520706
135Hyperphosphaturia (HP:0003109)1.48199556
136Widely patent fontanelles and sutures (HP:0004492)1.48157684
137Epiphyseal dysplasia (HP:0002656)1.47715000

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK5.28170517
2FGFR45.18821902
3ERN14.96974202
4SIK14.73210420
5ERBB44.24846654
6WNK43.45314383
7TAOK33.32149420
8INSRR3.10139109
9PIK3CA2.75758656
10CDK122.75330885
11DAPK22.33645214
12TYRO32.29294512
13MAPK112.26969654
14MAPK152.19503719
15MAP2K42.17968625
16PDGFRA2.05113044
17PTK62.03414675
18FGFR11.97810150
19TYK21.83616899
20AKT31.71557553
21WNK11.66379734
22JAK21.58193434
23TRIB31.56973541
24MST1R1.56854727
25ERBB21.56744587
26PIK3CG1.41180899
27FGFR21.39618786
28LATS11.37934535
29EPHB11.35818715
30MAP3K71.28940215
31EIF2AK11.27487734
32PKN11.26782779
33PKN21.25123487
34DDR21.23565689
35KDR1.20998090
36JAK11.20916730
37EEF2K1.19775491
38EPHA41.19369317
39MAP3K21.15361672
40NTRK31.12598350
41EPHA31.09216907
42PRKAA21.04403601
43FLT31.03610880
44CAMK2G0.99781946
45NEK90.99585514
46ABL20.97981417
47MAP3K140.96831101
48MAPK40.90315634
49TBK10.89955364
50MAPK120.87576199
51MAPKAPK30.86721984
52SGK30.81869939
53RIPK10.81162203
54PRKCZ0.80935620
55MET0.79732724
56SGK10.77371079
57GRK60.77309549
58PRKACG0.77035230
59CSNK1E0.76324520
60CDK70.76212010
61FGR0.75998607
62CAMK1D0.75176518
63SGK20.72810946
64PINK10.71801777
65DYRK1B0.70558292
66RPS6KB10.70017652
67PRKAA10.68865057
68CDC42BPA0.68711598
69TIE10.66410084
70SGK4940.66124212
71SGK2230.66124212
72MAP3K130.64787356
73CSK0.62690903
74FRK0.61946976
75BCR0.60841145
76PTK20.60616616
77MAP2K30.59762128
78FGFR30.58566840
79GSK3A0.56130532
80MAPK70.55558041
81CAMK1G0.54145288
82PRKCQ0.52513390
83PDPK10.52189915
84PRKCG0.51484631
85EPHA20.51125178
86NLK0.50965041
87PAK30.50442253
88CDK60.49530512
89ICK0.49507895
90MAP3K100.48977450
91MAP2K60.48469092
92CSNK1D0.48107386
93BRD40.46815082
94MATK0.45656729
95IRAK30.45001407
96BRSK20.44762395
97MAP3K50.43717020
98CSNK1G10.43185538
99BRSK10.42953653
100SRC0.42839459
101NEK20.41963575
102TGFBR20.40077997
103RET0.40024794
104NEK10.39369138
105IGF1R0.38632516
106MTOR0.38366741
107CDK40.38135083
108STK390.37832150
109EGFR0.37686069
110CSF1R0.37146298
111CAMK40.36730661
112CSNK2A20.36017704
113MAP3K10.35946810
114BMX0.34977792
115KSR20.34018825
116CSNK1A1L0.33832882
117IKBKE0.33481205
118CSNK2A10.32940039
119CSNK1G20.32408200
120MAP3K30.32340408
121MARK20.31778945
122PDGFRB0.31772174
123NTRK10.30341088
124PRKCA0.30173236
125DAPK10.29268572
126SMG10.29003982
127MAP3K110.28940840
128NTRK20.28930043
129PRKACB0.28722613
130MAPK30.28127517
131MAP2K10.27864311
132PRKACA0.27336520
133CSNK1G30.26467788
134SIK20.26280794
135PRKCB0.25362312
136RPS6KA30.24569943
137MAP3K60.24162397
138PRKG10.24085521
139DAPK30.23806571
140PDK10.23584337
141LATS20.22421410
142ABL10.22331548
143GRK10.22253597
144PRKCH0.21921863

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001204.63177878
2Nitrogen metabolism_Homo sapiens_hsa009104.06321489
3Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.31141953
4Complement and coagulation cascades_Homo sapiens_hsa046103.28062632
5Arginine biosynthesis_Homo sapiens_hsa002203.09476657
6Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.89539650
7Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.83751310
8Tryptophan metabolism_Homo sapiens_hsa003802.66905344
9Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.60525647
10Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.55660361
11Fatty acid degradation_Homo sapiens_hsa000712.51171839
12Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.21179349
13Staphylococcus aureus infection_Homo sapiens_hsa051502.18967172
14Butanoate metabolism_Homo sapiens_hsa006502.10291733
15Peroxisome_Homo sapiens_hsa041462.09486120
16Histidine metabolism_Homo sapiens_hsa003402.04929099
17PPAR signaling pathway_Homo sapiens_hsa033201.94833941
18Pentose and glucuronate interconversions_Homo sapiens_hsa000401.92867772
19Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.88607186
20Fatty acid metabolism_Homo sapiens_hsa012121.83236015
21Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.79825497
22Chemical carcinogenesis_Homo sapiens_hsa052041.76224970
23Selenocompound metabolism_Homo sapiens_hsa004501.72181794
24Propanoate metabolism_Homo sapiens_hsa006401.68554649
25Steroid hormone biosynthesis_Homo sapiens_hsa001401.67473372
26Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.59812545
27Drug metabolism - other enzymes_Homo sapiens_hsa009831.59777958
28Bile secretion_Homo sapiens_hsa049761.59726699
29Retinol metabolism_Homo sapiens_hsa008301.51642551
30beta-Alanine metabolism_Homo sapiens_hsa004101.51124721
312-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.49641657
32Tyrosine metabolism_Homo sapiens_hsa003501.49007402
33Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.46843221
34Caffeine metabolism_Homo sapiens_hsa002321.45430026
35Phenylalanine metabolism_Homo sapiens_hsa003601.44551693
36Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.41371753
37Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.39464438
38ABC transporters_Homo sapiens_hsa020101.38142476
39Cysteine and methionine metabolism_Homo sapiens_hsa002701.34389793
40Vitamin B6 metabolism_Homo sapiens_hsa007501.30148033
41Steroid biosynthesis_Homo sapiens_hsa001001.28332011
42Pyruvate metabolism_Homo sapiens_hsa006201.21500000
43Fatty acid elongation_Homo sapiens_hsa000621.21188158
44Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.21124470
45Maturity onset diabetes of the young_Homo sapiens_hsa049501.18124057
46Starch and sucrose metabolism_Homo sapiens_hsa005001.16814431
47Fat digestion and absorption_Homo sapiens_hsa049751.15612662
48Biosynthesis of amino acids_Homo sapiens_hsa012301.15580564
49Folate biosynthesis_Homo sapiens_hsa007901.13085074
50Sulfur metabolism_Homo sapiens_hsa009201.08580584
51Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.05174739
52Carbon metabolism_Homo sapiens_hsa012001.01596959
53Cyanoamino acid metabolism_Homo sapiens_hsa004600.96115639
54Arginine and proline metabolism_Homo sapiens_hsa003300.95849136
55Vitamin digestion and absorption_Homo sapiens_hsa049770.88549006
56Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.86692857
57Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.85527394
58Sulfur relay system_Homo sapiens_hsa041220.85270992
59Lysine degradation_Homo sapiens_hsa003100.82332459
60One carbon pool by folate_Homo sapiens_hsa006700.81556228
61Arachidonic acid metabolism_Homo sapiens_hsa005900.70760581
62Glycerolipid metabolism_Homo sapiens_hsa005610.67041124
63Fatty acid biosynthesis_Homo sapiens_hsa000610.66434687
64Other glycan degradation_Homo sapiens_hsa005110.65650581
65Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.65426813
66Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.58403441
67Glutathione metabolism_Homo sapiens_hsa004800.51408294
68Prion diseases_Homo sapiens_hsa050200.47390736
69Pentose phosphate pathway_Homo sapiens_hsa000300.47337294
70Metabolic pathways_Homo sapiens_hsa011000.42365197
71alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.39184558
72Renin-angiotensin system_Homo sapiens_hsa046140.37069890
73Insulin resistance_Homo sapiens_hsa049310.32037903
74Adipocytokine signaling pathway_Homo sapiens_hsa049200.31129488
75Galactose metabolism_Homo sapiens_hsa000520.30404513
76Glycerophospholipid metabolism_Homo sapiens_hsa005640.28736486
77Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.28263819
78N-Glycan biosynthesis_Homo sapiens_hsa005100.23998421
79Glucagon signaling pathway_Homo sapiens_hsa049220.22180477
80Fructose and mannose metabolism_Homo sapiens_hsa000510.20067056
81Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.14574838
82Mineral absorption_Homo sapiens_hsa049780.11403017
83Linoleic acid metabolism_Homo sapiens_hsa005910.09676804
84Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.08905548
85Bladder cancer_Homo sapiens_hsa052190.02535163
86AMPK signaling pathway_Homo sapiens_hsa041520.02313526
87Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.00109173
88Amoebiasis_Homo sapiens_hsa05146-0.2240358
89GABAergic synapse_Homo sapiens_hsa04727-0.2208426
90Regulation of autophagy_Homo sapiens_hsa04140-0.2146794
91Ether lipid metabolism_Homo sapiens_hsa00565-0.2080594
92Type II diabetes mellitus_Homo sapiens_hsa04930-0.2020889
93Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550-0.1930152
94Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520-0.1904556
95Pertussis_Homo sapiens_hsa05133-0.1838199
96Carbohydrate digestion and absorption_Homo sapiens_hsa04973-0.1666631
97Dorso-ventral axis formation_Homo sapiens_hsa04320-0.1523609
98Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604-0.1512810
99Other types of O-glycan biosynthesis_Homo sapiens_hsa00514-0.1433273
100Glycosaminoglycan degradation_Homo sapiens_hsa00531-0.1357121
101African trypanosomiasis_Homo sapiens_hsa05143-0.1344010
102Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932-0.1342676
103Thyroid hormone synthesis_Homo sapiens_hsa04918-0.1268884
104Hepatitis C_Homo sapiens_hsa05160-0.1005383
105Circadian rhythm_Homo sapiens_hsa04710-0.0970788
106Central carbon metabolism in cancer_Homo sapiens_hsa05230-0.0894210
107Insulin signaling pathway_Homo sapiens_hsa04910-0.0778286
108Systemic lupus erythematosus_Homo sapiens_hsa05322-0.0762339
109ECM-receptor interaction_Homo sapiens_hsa04512-0.0489667
110Sphingolipid metabolism_Homo sapiens_hsa00600-0.0445987
111Ovarian steroidogenesis_Homo sapiens_hsa04913-0.0084421

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