ITIH4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is secreted into the blood, where it is cleaved by plasma kallikrein into two smaller forms. Expression of this gene has been detected only in liver, and it seems to be upregulated during surgical trauma. This gene is part of a cluster of similar genes on chromosome 3. Two transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1exogenous drug catabolic process (GO:0042738)9.88962112
2omega-hydroxylase P450 pathway (GO:0097267)8.78646241
3epoxygenase P450 pathway (GO:0019373)8.65302797
4erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)7.54366956
5L-phenylalanine catabolic process (GO:0006559)7.54366956
6L-phenylalanine metabolic process (GO:0006558)7.20438879
7erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)7.20438879
8aromatic amino acid family catabolic process (GO:0009074)6.75644691
9triglyceride-rich lipoprotein particle remodeling (GO:0034370)6.34220690
10drug metabolic process (GO:0017144)6.13192477
11tryptophan catabolic process (GO:0006569)6.09863021
12indole-containing compound catabolic process (GO:0042436)6.09863021
13indolalkylamine catabolic process (GO:0046218)6.09863021
14kynurenine metabolic process (GO:0070189)5.98452891
15oxidative demethylation (GO:0070989)5.96264067
16bile acid biosynthetic process (GO:0006699)5.88209841
17negative regulation of fibrinolysis (GO:0051918)5.81006714
18tryptophan metabolic process (GO:0006568)5.73594616
19glyoxylate metabolic process (GO:0046487)5.72588545
20urea metabolic process (GO:0019627)5.70932431
21urea cycle (GO:0000050)5.70932431
22regulation of protein activation cascade (GO:2000257)5.63210936
23regulation of fibrinolysis (GO:0051917)5.58926148
24high-density lipoprotein particle remodeling (GO:0034375)5.58255304
25alpha-linolenic acid metabolic process (GO:0036109)5.58213052
26complement activation, alternative pathway (GO:0006957)5.57965930
27peptidyl-glutamic acid carboxylation (GO:0017187)5.51472688
28protein carboxylation (GO:0018214)5.51472688
29regulation of plasminogen activation (GO:0010755)5.40651222
30cysteine metabolic process (GO:0006534)5.31812413
31sulfur amino acid catabolic process (GO:0000098)5.24600390
32nitrogen cycle metabolic process (GO:0071941)5.24275744
33regulation of complement activation (GO:0030449)5.21377566
34regulation of humoral immune response (GO:0002920)5.09140825
35serine family amino acid catabolic process (GO:0009071)5.08228963
36bile acid metabolic process (GO:0008206)5.04754122
37ethanol metabolic process (GO:0006067)4.94133887
38reverse cholesterol transport (GO:0043691)4.91647390
39phenylpropanoid metabolic process (GO:0009698)4.91600816
40aromatic amino acid family metabolic process (GO:0009072)4.90069070
41regulation of cholesterol esterification (GO:0010872)4.88281104
42positive regulation of heterotypic cell-cell adhesion (GO:0034116)4.85888099
43negative regulation of hemostasis (GO:1900047)4.85638618
44negative regulation of blood coagulation (GO:0030195)4.85638618
45fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.83100915
46regulation of triglyceride catabolic process (GO:0010896)4.82059944
47plasma lipoprotein particle remodeling (GO:0034369)4.81948449
48protein-lipid complex remodeling (GO:0034368)4.81948449
49macromolecular complex remodeling (GO:0034367)4.81948449
50tyrosine metabolic process (GO:0006570)4.77543933
51homocysteine metabolic process (GO:0050667)4.76987494
52S-adenosylmethionine metabolic process (GO:0046500)4.64524445
53triglyceride homeostasis (GO:0070328)4.63669835
54acylglycerol homeostasis (GO:0055090)4.63669835
55alpha-amino acid catabolic process (GO:1901606)4.59747578
56phospholipid efflux (GO:0033700)4.59600066
57amino-acid betaine metabolic process (GO:0006577)4.54219814
58lysine catabolic process (GO:0006554)4.52624884
59lysine metabolic process (GO:0006553)4.52624884
60negative regulation of sterol transport (GO:0032372)4.51490508
61negative regulation of cholesterol transport (GO:0032375)4.51490508
62disruption of cells of other organism involved in symbiotic interaction (GO:0051818)4.47248111
63killing of cells in other organism involved in symbiotic interaction (GO:0051883)4.47248111
64plasma lipoprotein particle clearance (GO:0034381)4.41860189
65negative regulation of coagulation (GO:0050819)4.40581192
66bile acid and bile salt transport (GO:0015721)4.38521522
67negative regulation of wound healing (GO:0061045)4.38334894
68cellular ketone body metabolic process (GO:0046950)4.37506083
69glycine metabolic process (GO:0006544)4.36438864
70coenzyme catabolic process (GO:0009109)4.34810092
71imidazole-containing compound metabolic process (GO:0052803)4.32876349
72indolalkylamine metabolic process (GO:0006586)4.31069741
73cholesterol efflux (GO:0033344)4.28795693
74glutamate metabolic process (GO:0006536)4.22592519
75cellular amino acid catabolic process (GO:0009063)4.21563410
76positive regulation of hemostasis (GO:1900048)4.21555009
77positive regulation of blood coagulation (GO:0030194)4.21555009
78amine catabolic process (GO:0009310)4.21438563
79cellular biogenic amine catabolic process (GO:0042402)4.21438563
80alkaloid metabolic process (GO:0009820)4.19438242
81cellular glucuronidation (GO:0052695)4.16248706
82fibrinolysis (GO:0042730)4.13695702
83serine family amino acid metabolic process (GO:0009069)4.12872527
84benzene-containing compound metabolic process (GO:0042537)4.08696625
85plasma lipoprotein particle assembly (GO:0034377)4.04310672
86low-density lipoprotein particle remodeling (GO:0034374)4.03863304
87cellular modified amino acid catabolic process (GO:0042219)4.03162727
88dicarboxylic acid biosynthetic process (GO:0043650)4.01580405
89ethanol oxidation (GO:0006069)3.99631209
90arginine metabolic process (GO:0006525)3.99554680
91serine family amino acid biosynthetic process (GO:0009070)3.96606585
92blood coagulation, intrinsic pathway (GO:0007597)3.96133342
93flavonoid metabolic process (GO:0009812)3.91834870
94aldehyde catabolic process (GO:0046185)3.91626993
95complement activation, classical pathway (GO:0006958)3.90864515
96positive regulation of coagulation (GO:0050820)3.87925328
97protein activation cascade (GO:0072376)3.86929279
98complement activation (GO:0006956)3.86437790
99drug catabolic process (GO:0042737)3.84645556
100hormone catabolic process (GO:0042447)3.82664705
101negative regulation of protein activation cascade (GO:2000258)3.81938248
102positive regulation of triglyceride lipase activity (GO:0061365)3.81775038
103positive regulation of lipoprotein lipase activity (GO:0051006)3.81775038
104phospholipid homeostasis (GO:0055091)3.79526991
105cofactor catabolic process (GO:0051187)3.78541353
106ketone body metabolic process (GO:1902224)3.78485092
107very-low-density lipoprotein particle assembly (GO:0034379)3.77772491
108cholesterol homeostasis (GO:0042632)3.75322335
109positive regulation of lipid catabolic process (GO:0050996)3.74503562
110negative regulation of lipase activity (GO:0060192)3.73196147
111regulation of bile acid biosynthetic process (GO:0070857)3.72980609
112intestinal cholesterol absorption (GO:0030299)3.72531814
113response to mercury ion (GO:0046689)3.71578970
114regulation of cholesterol homeostasis (GO:2000188)3.71375220
115opsonization (GO:0008228)3.71074424
116cytolysis (GO:0019835)3.70453165
117sterol homeostasis (GO:0055092)3.69136334
118glucuronate metabolic process (GO:0019585)3.68518452
119uronic acid metabolic process (GO:0006063)3.68518452
120negative regulation of complement activation (GO:0045916)3.68060039
121organic acid catabolic process (GO:0016054)3.68000140
122carboxylic acid catabolic process (GO:0046395)3.68000140
123plasma lipoprotein particle organization (GO:0071827)3.66906383
124* acute-phase response (GO:0006953)3.65593548
125regulation of apoptotic cell clearance (GO:2000425)3.63150089
126protein-lipid complex assembly (GO:0065005)3.62296733
127acetyl-CoA metabolic process (GO:0006084)3.60534542
128regulation of acute inflammatory response (GO:0002673)3.55608498
129heme transport (GO:0015886)3.55565720
130positive regulation of fatty acid biosynthetic process (GO:0045723)3.54882760
131* acute inflammatory response (GO:0002526)3.52859317
132fat-soluble vitamin biosynthetic process (GO:0042362)3.45089390
133xenobiotic metabolic process (GO:0006805)3.40169465
134regulation of lipoprotein particle clearance (GO:0010984)3.38052769

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* RXR_22158963_ChIP-Seq_LIVER_Mouse8.33435588
2* PPARA_22158963_ChIP-Seq_LIVER_Mouse7.13967549
3EGR1_23403033_ChIP-Seq_LIVER_Mouse6.97799775
4LXR_22158963_ChIP-Seq_LIVER_Mouse6.49985591
5FOXO1_23066095_ChIP-Seq_LIVER_Mouse5.30292781
6CEBPA_23403033_ChIP-Seq_LIVER_Mouse5.20202797
7PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.84160970
8NR1I2_20693526_ChIP-Seq_LIVER_Mouse4.11402219
9* CEBPB_23403033_ChIP-Seq_LIVER_Mouse3.96691903
10TCF7L2_21901280_ChIP-Seq_H4IIE_Rat2.05669578
11ESR1_17901129_ChIP-ChIP_LIVER_Mouse12.0174458
12HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.95483118
13TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.93811571
14FOXA2_19822575_ChIP-Seq_HepG2_Human1.64332393
15CLOCK_20551151_ChIP-Seq_293T_Human1.57932816
16HTT_18923047_ChIP-ChIP_STHdh_Human1.53049405
17GATA1_22025678_ChIP-Seq_K562_Human1.50034158
18HNF4A_19822575_ChIP-Seq_HepG2_Human1.40893129
19STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.30699951
20MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.25126755
21STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.20838628
22TRIM28_21343339_ChIP-Seq_HEK293_Human1.20244866
23RXRA_24833708_ChIP-Seq_LIVER_Mouse1.18831231
24ESR1_15608294_ChIP-ChIP_MCF-7_Human1.13572220
25* THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.09995977
26IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.03892062
27ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.99436647
28IRF8_22096565_ChIP-ChIP_GC-B_Human0.93426196
29SOX2_27498859_Chip-Seq_STOMACH_Mouse0.93201212
30TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.90595026
31PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.90425105
32RARG_19884340_ChIP-ChIP_MEFs_Mouse0.85342348
33CDX2_21074721_ChIP-Seq_CACO-2_Mouse0.85142231
34PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.83803581
35AUTS2_25519132_ChIP-Seq_293T-REX_Human0.82649355
36HNFA_21074721_ChIP-Seq_CACO-2_Human0.82604842
37ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.81711035
38GATA4_25053715_ChIP-Seq_YYC3_Human0.80753621
39BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.80292573
40PHF8_20622853_ChIP-Seq_HELA_Human0.77522778
41GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.76523451
42SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.76015362
43Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.74566072
44ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.73832441
45SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.72503577
46ZNF263_19887448_ChIP-Seq_K562_Human0.72343913
47RARA_24833708_ChIP-Seq_LIVER_Mouse0.72230791
48KAP1_22055183_ChIP-Seq_ESCs_Mouse0.71877420
49* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.71595284
50NFE2_27457419_Chip-Seq_LIVER_Mouse0.70929717
51SOX2_21211035_ChIP-Seq_LN229_Human0.70911054
52ESR2_21235772_ChIP-Seq_MCF-7_Human0.70568895
53AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.69936227
54SALL4_18804426_ChIP-ChIP_XEN_Mouse0.69858199
55GATA6_21074721_ChIP-Seq_CACO-2_Human0.69533710
56NFYA_21822215_ChIP-Seq_K562_Human0.69176818
57RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.68204961
58SPI1_20517297_ChIP-Seq_HL60_Human0.66023086
59NRF2_20460467_ChIP-Seq_MEFs_Mouse0.65251871
60NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.65251871
61RAC3_21632823_ChIP-Seq_H3396_Human0.62860204
62SMC4_20622854_ChIP-Seq_HELA_Human0.62026675
63NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.61715238
64CTCF_27219007_Chip-Seq_Bcells_Human0.61710032
65RARB_24833708_ChIP-Seq_LIVER_Mouse0.61602242
66GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.60843004
67FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.60830746
68ETV2_25802403_ChIP-Seq_MESCs_Mouse0.60085866
69TP53_18474530_ChIP-ChIP_U2OS_Human0.59812630
70BP1_19119308_ChIP-ChIP_Hs578T_Human0.59611064
71RAD21_21589869_ChIP-Seq_MESCs_Mouse0.59460857
72CBX2_22325352_ChIP-Seq_293T-Rex_Human0.58940063
73NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.58696726
74ELF1_20517297_ChIP-Seq_JURKAT_Human0.58499176
75BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.57900096
76NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.57353204
77CEBPB_22108803_ChIP-Seq_LS180_Human0.56854863
78ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.56379437
79EZH2_27294783_Chip-Seq_NPCs_Mouse0.56182090
80SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.55767527
81DNAJC2_21179169_ChIP-ChIP_NT2_Human0.55287837
82FOXA1_25552417_ChIP-Seq_VCAP_Human0.53825009
83EGR1_19032775_ChIP-ChIP_M12_Human0.53217023
84E2F1_20622854_ChIP-Seq_HELA_Human0.53142984
85ETV1_20927104_ChIP-Seq_GIST48_Human0.53079660
86FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.52888387
87ER_23166858_ChIP-Seq_MCF-7_Human0.52842723
88STAT3_1855785_ChIP-Seq_MESCs_Mouse0.52693887
89MYC_19829295_ChIP-Seq_ESCs_Human0.51279264
90* LXR_22292898_ChIP-Seq_THP-1_Human0.51187195
91AR_20517297_ChIP-Seq_VCAP_Human0.50761803
92P63_20808887_ChIP-Seq_KERATINOCYTES_Human0.50734455
93PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.50626569
94* SA1_27219007_Chip-Seq_Bcells_Human0.50464521
95FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.50450975
96MYC_19915707_ChIP-ChIP_AK7_Human0.50032203
97EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.49810994
98ESR1_21235772_ChIP-Seq_MCF-7_Human0.49178682
99GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.48685808
100ERG_20517297_ChIP-Seq_VCAP_Human0.48202390
101CBP_21632823_ChIP-Seq_H3396_Human0.47651083
102CDX2_20551321_ChIP-Seq_CACO-2_Human0.47153666
103ESET_19884257_ChIP-Seq_ESCs_Mouse0.47050626
104FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.46825408
105PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.45656977
106STAT1_17558387_ChIP-Seq_HELA_Human0.45564253
107P53_21459846_ChIP-Seq_SAOS-2_Human0.45555282
108GATA1_19941826_ChIP-Seq_K562_Human0.44838360
109PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.44825126
110FOXO3_23340844_ChIP-Seq_DLD1_Human0.44626068
111ESR1_20079471_ChIP-ChIP_T-47D_Human0.44121387
112TAF15_26573619_Chip-Seq_HEK293_Human0.42631641
113FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.42611497
114PPAR_26484153_Chip-Seq_NCI-H1993_Human0.42225146
115GATA2_19941826_ChIP-Seq_K562_Human0.41553217
116GATA1_19941827_ChIP-Seq_MEL_Mouse0.41526676
117PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.40917683
118GATA6_25053715_ChIP-Seq_YYC3_Human0.40639170
119E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.40156897
120BCAT_22108803_ChIP-Seq_LS180_Human0.39823470
121* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.39464637
122ERG_21242973_ChIP-ChIP_JURKAT_Human0.39304426
123GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.38890399
124STAT3_19079543_ChIP-ChIP_MESCs_Mouse0.38672423
125* TAF2_19829295_ChIP-Seq_ESCs_Human0.38545406
126CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.38011627
127* MYC_27129775_Chip-Seq_CORNEA_Mouse0.35805815
128SOX2_20726797_ChIP-Seq_SW620_Human0.34925906
129LUZP1_20508642_ChIP-Seq_ESCs_Mouse0.34124745
130CDX2_22108803_ChIP-Seq_LS180_Human0.33808237
131FOXH1_21741376_ChIP-Seq_EPCs_Human0.33663313
132IRF1_19129219_ChIP-ChIP_H3396_Human0.33558422
133SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.33229957
134SPI1_26923725_Chip-Seq_HPCs_Mouse0.33180258

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system8.21609570
2MP0005360_urolithiasis7.50428025
3MP0005085_abnormal_gallbladder_physiolo6.43512322
4MP0005365_abnormal_bile_salt6.13348881
5MP0008875_abnormal_xenobiotic_pharmacok5.06327598
6MP0003806_abnormal_nucleotide_metabolis4.20131965
7MP0003252_abnormal_bile_duct3.86338852
8MP0010329_abnormal_lipoprotein_level3.61361718
9MP0009840_abnormal_foam_cell3.31473455
10MP0005083_abnormal_biliary_tract3.23946079
11MP0003195_calcinosis2.80411357
12MP0005332_abnormal_amino_acid2.72739146
13MP0001666_abnormal_nutrient_absorption2.62323928
14MP0003191_abnormal_cellular_cholesterol2.53147232
15* MP0000609_abnormal_liver_physiology2.14948273
16MP0002118_abnormal_lipid_homeostasis2.11365829
17MP0004019_abnormal_vitamin_homeostasis2.09754768
18MP0002138_abnormal_hepatobiliary_system1.99939838
19MP0003868_abnormal_feces_composition1.91494324
20MP0005319_abnormal_enzyme/_coenzyme1.81942416
21MP0001764_abnormal_homeostasis1.61287301
22MP0009697_abnormal_copulation1.56516885
23MP0005584_abnormal_enzyme/coenzyme_acti1.55813619
24MP0003011_delayed_dark_adaptation1.43019718
25MP0005451_abnormal_body_composition1.35862000
26MP0003656_abnormal_erythrocyte_physiolo1.26150619
27MP0003186_abnormal_redox_activity1.22518225
28MP0003705_abnormal_hypodermis_morpholog1.21625408
29MP0009643_abnormal_urine_homeostasis1.21621604
30MP0000598_abnormal_liver_morphology1.19050764
31MP0000604_amyloidosis1.15660685
32MP0005647_abnormal_sex_gland1.14628123
33MP0002254_reproductive_system_inflammat1.10472971
34MP0009764_decreased_sensitivity_to1.08947138
35MP0010368_abnormal_lymphatic_system1.07577222
36MP0009763_increased_sensitivity_to1.05818676
37MP0005636_abnormal_mineral_homeostasis0.92476465
38MP0008469_abnormal_protein_level0.91546791
39MP0009642_abnormal_blood_homeostasis0.87732794
40MP0005408_hypopigmentation0.84786861
41MP0005670_abnormal_white_adipose0.83689965
42MP0003879_abnormal_hair_cell0.82997962
43MP0009765_abnormal_xenobiotic_induced0.79750719
44MP0005220_abnormal_exocrine_pancreas0.78424428
45MP0005376_homeostasis/metabolism_phenot0.78223730
46MP0005084_abnormal_gallbladder_morpholo0.78076990
47MP0006036_abnormal_mitochondrial_physio0.77892262
48MP0002078_abnormal_glucose_homeostasis0.77158912
49MP0002282_abnormal_trachea_morphology0.76898637
50MP0001915_intracranial_hemorrhage0.75575516
51MP0002971_abnormal_brown_adipose0.74214518
52MP0002876_abnormal_thyroid_physiology0.73212802
53MP0001661_extended_life_span0.72554614
54MP0009785_altered_susceptibility_to0.70019094
55MP0004130_abnormal_muscle_cell0.69971904
56MP0003690_abnormal_glial_cell0.69947726
57MP0005334_abnormal_fat_pad0.69196884
58MP0002249_abnormal_larynx_morphology0.67871606
59MP0009053_abnormal_anal_canal0.66844795
60MP0005535_abnormal_body_temperature0.65033107
61MP0005187_abnormal_penis_morphology0.64145839
62MP0003329_amyloid_beta_deposits0.63180586
63MP0000639_abnormal_adrenal_gland0.61998602
64MP0005266_abnormal_metabolism0.61105045
65MP0005464_abnormal_platelet_physiology0.61012541
66MP0005023_abnormal_wound_healing0.60608144
67MP0001756_abnormal_urination0.57312690
68MP0005448_abnormal_energy_balance0.56568731
69MP0006035_abnormal_mitochondrial_morpho0.53921767
70MP0002332_abnormal_exercise_endurance0.53886528
71MP0004782_abnormal_surfactant_physiolog0.52626223
72MP0005395_other_phenotype0.51823177
73MP0003724_increased_susceptibility_to0.51821920
74MP0003436_decreased_susceptibility_to0.49037716
75MP0003638_abnormal_response/metabolism_0.47428327
76MP0002822_catalepsy0.45431905
77MP0002136_abnormal_kidney_physiology0.45102550
78MP0005058_abnormal_lysosome_morphology0.44973438
79MP0002928_abnormal_bile_duct0.44611512
80MP0008873_increased_physiological_sensi0.44466819
81MP0003718_maternal_effect0.44408776
82MP0008874_decreased_physiological_sensi0.43644641
83MP0003075_altered_response_to0.42202048
84MP0005248_abnormal_Harderian_gland0.40963734
85MP0005166_decreased_susceptibility_to0.40669860
86MP0003953_abnormal_hormone_level0.39880516
87MP0000579_abnormal_nail_morphology0.39870992
88MP0005666_abnormal_adipose_tissue0.38687914
89MP0002837_dystrophic_cardiac_calcinosis0.38196100
90MP0009384_cardiac_valve_regurgitation0.38101679
91MP0000467_abnormal_esophagus_morphology0.35353250
92MP0000249_abnormal_blood_vessel0.35004000
93MP0004883_abnormal_blood_vessel0.34140555
94MP0009672_abnormal_birth_weight0.33966453
95MP0002168_other_aberrant_phenotype0.33447505
96MP0008872_abnormal_physiological_respon0.33402819
97MP0004381_abnormal_hair_follicle0.33223593
98MP0009115_abnormal_fat_cell0.32901959
99MP0001851_eye_inflammation0.32824855
100MP0002796_impaired_skin_barrier0.32455613
101MP0001243_abnormal_dermal_layer0.31885867
102MP0003646_muscle_fatigue0.31672099
103MP0006082_CNS_inflammation0.30744026
104MP0002970_abnormal_white_adipose0.30559435
105MP0001853_heart_inflammation0.30415300
106MP0001545_abnormal_hematopoietic_system0.29643939
107MP0005397_hematopoietic_system_phenotyp0.29643939
108MP0001881_abnormal_mammary_gland0.29616458
109MP0001845_abnormal_inflammatory_respons0.29572739
110MP0000230_abnormal_systemic_arterial0.29408232
111MP0005164_abnormal_response_to0.28635893
112MP0002132_abnormal_respiratory_system0.27050085
113MP0002060_abnormal_skin_morphology0.25274597
114MP0000427_abnormal_hair_cycle0.25106651
115MP0002419_abnormal_innate_immunity0.24831723
116MP0003959_abnormal_lean_body0.22644200
117MP0002128_abnormal_blood_circulation0.22363698
118MP0000920_abnormal_myelination0.21900097
119MP0005025_abnormal_response_to0.20901036

Predicted human phenotypes

RankGene SetZ-score
1Deep venous thrombosis (HP:0002625)7.55993213
2Abnormality of aromatic amino acid family metabolism (HP:0004338)7.30883719
3Intrahepatic cholestasis (HP:0001406)7.25120451
4Prolonged partial thromboplastin time (HP:0003645)6.72777367
5Abnormality of monocarboxylic acid metabolism (HP:0010996)6.63889308
6Hypobetalipoproteinemia (HP:0003563)6.41764777
7Xanthomatosis (HP:0000991)6.26259970
8Complement deficiency (HP:0004431)5.65271637
9Hyperlipoproteinemia (HP:0010980)5.61413150
10Joint hemorrhage (HP:0005261)4.94665817
11Hypolipoproteinemia (HP:0010981)4.84608983
12Abnormality of the common coagulation pathway (HP:0010990)4.84107345
13Hyperammonemia (HP:0001987)4.55006349
14Epidermoid cyst (HP:0200040)4.53347030
15Abnormality of the level of lipoprotein cholesterol (HP:0010979)4.43839479
16Hyperglycinemia (HP:0002154)4.35167955
17Hypoalphalipoproteinemia (HP:0003233)4.26815592
18Abnormality of methionine metabolism (HP:0010901)4.24266501
19Abnormality of sulfur amino acid metabolism (HP:0004339)4.20715300
20Ketosis (HP:0001946)4.17459823
21Fat malabsorption (HP:0002630)4.14212505
22Abnormality of complement system (HP:0005339)4.12824976
23Abnormality of glutamine family amino acid metabolism (HP:0010902)4.09149711
24Abnormality of aspartate family amino acid metabolism (HP:0010899)4.08454748
25Abnormality of the intrinsic pathway (HP:0010989)3.88617185
26Abnormality of serine family amino acid metabolism (HP:0010894)3.81420793
27Abnormality of glycine metabolism (HP:0010895)3.81420793
28Hypoglycemic coma (HP:0001325)3.80461781
29Hyperglycinuria (HP:0003108)3.78889600
30Abnormality of pyrimidine metabolism (HP:0004353)3.77298100
31Conjugated hyperbilirubinemia (HP:0002908)3.74304257
32Hypercholesterolemia (HP:0003124)3.62899383
33Spontaneous abortion (HP:0005268)3.57816242
34Hyperbilirubinemia (HP:0002904)3.29007817
35Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.25479097
36Abnormality of fatty-acid metabolism (HP:0004359)3.22018627
37Steatorrhea (HP:0002570)3.09872951
38Myocardial infarction (HP:0001658)3.02969209
39Delayed CNS myelination (HP:0002188)3.01436126
40Abnormality of nucleobase metabolism (HP:0010932)3.00727719
41Abnormality of serum amino acid levels (HP:0003112)2.99773286
42Hypochromic microcytic anemia (HP:0004840)2.98043118
43Hepatocellular carcinoma (HP:0001402)2.97777609
44Ketoacidosis (HP:0001993)2.93652337
45Systemic lupus erythematosus (HP:0002725)2.84817907
46Skin nodule (HP:0200036)2.81600755
47Metabolic acidosis (HP:0001942)2.68737868
48Purpura (HP:0000979)2.65609084
49Glomerulonephritis (HP:0000099)2.65381010
50Abnormality of purine metabolism (HP:0004352)2.62442528
51Acanthocytosis (HP:0001927)2.62186404
52Vascular calcification (HP:0004934)2.58747574
53Amyloidosis (HP:0011034)2.54082775
54Lethargy (HP:0001254)2.53458177
55Gingival bleeding (HP:0000225)2.50946951
56Osteomalacia (HP:0002749)2.48923505
57Hypoglycemic seizures (HP:0002173)2.47383080
58Abnormality of dicarboxylic acid metabolism (HP:0010995)2.46446695
59Dicarboxylic aciduria (HP:0003215)2.46446695
60Abnormal gallbladder morphology (HP:0012437)2.46000551
61Recurrent gram-negative bacterial infections (HP:0005420)2.45151469
62Spastic diplegia (HP:0001264)2.44937192
63Mitral stenosis (HP:0001718)2.43839972
64Gout (HP:0001997)2.42265489
65Cholelithiasis (HP:0001081)2.40620530
66Cholecystitis (HP:0001082)2.38426516
67Abnormal gallbladder physiology (HP:0012438)2.38426516
68Cerebral edema (HP:0002181)2.34560475
69Neonatal hypoglycemia (HP:0001998)2.33889203
70Fair hair (HP:0002286)2.32903253
71Irritability (HP:0000737)2.30936318
72Esophageal varix (HP:0002040)2.30372347
73Cardiovascular calcification (HP:0011915)2.29767991
74Neonatal onset (HP:0003623)2.28837570
75Thrombophlebitis (HP:0004418)2.27299672
76Joint swelling (HP:0001386)2.23540329
77Menorrhagia (HP:0000132)2.23080916
78Malnutrition (HP:0004395)2.22888768
79Pancreatitis (HP:0001733)2.11491136
80Late onset (HP:0003584)2.10987835
81Sensorimotor neuropathy (HP:0007141)2.10223175
82Brushfield spots (HP:0001088)2.06451306
83Enlarged kidneys (HP:0000105)2.05914070
84Increased serum ferritin (HP:0003281)2.03714430
85Poikilocytosis (HP:0004447)2.03612468
86Hemorrhage of the eye (HP:0011885)2.03168504
87Vomiting (HP:0002013)2.01755943
88Hyperinsulinemic hypoglycemia (HP:0000825)2.00088960
89Abnormality of the gallbladder (HP:0005264)1.99445305
90Opisthotonus (HP:0002179)1.98984638
91Abnormality of the Achilles tendon (HP:0005109)1.98365384
92Elevated alkaline phosphatase (HP:0003155)1.95647299
93Abnormality of iron homeostasis (HP:0011031)1.94529916
94Epistaxis (HP:0000421)1.93338225
95Generalized aminoaciduria (HP:0002909)1.92475435
96Abnormality of transition element cation homeostasis (HP:0011030)1.91631229
97Reduced antithrombin III activity (HP:0001976)1.90900029
98Gangrene (HP:0100758)1.89489888
99Hyperphosphaturia (HP:0003109)1.89026531
100Nephritis (HP:0000123)1.87953299
101Rickets (HP:0002748)1.87761077
102Hypophosphatemic rickets (HP:0004912)1.84338940
103Abnormal cartilage morphology (HP:0002763)1.83688157
104Abnormality of vitamin metabolism (HP:0100508)1.80587889
105Elevated hepatic transaminases (HP:0002910)1.78986034
106Hydroxyprolinuria (HP:0003080)1.78465311
107Abnormality of proline metabolism (HP:0010907)1.78465311
108Alkalosis (HP:0001948)1.77924726
109Abnormality of alkaline phosphatase activity (HP:0004379)1.77746621
110Abnormal enzyme/coenzyme activity (HP:0012379)1.77599950
111Renal cortical cysts (HP:0000803)1.77149572
112Status epilepticus (HP:0002133)1.76962501
113Cerebral palsy (HP:0100021)1.76663485
114Arthropathy (HP:0003040)1.75161917
115Pulmonary embolism (HP:0002204)1.72640365
116Hyperglycemia (HP:0003074)1.72513228
117Glycosuria (HP:0003076)1.71397945
118Abnormality of urine glucose concentration (HP:0011016)1.71397945
119Abnormal delivery (HP:0001787)1.69190243
120Increased mean platelet volume (HP:0011877)1.67555859
121Bifid scrotum (HP:0000048)1.66773148
122Atrioventricular block (HP:0001678)1.65173632
123Generalized hypopigmentation of hair (HP:0011358)1.61511643
124Abnormal platelet volume (HP:0011876)1.54333054
125Abnormal urine phosphate concentration (HP:0012599)1.51639428
126Impaired platelet aggregation (HP:0003540)1.50272635
127Abnormal platelet function (HP:0011869)1.50272635
128Abnormal biliary tract physiology (HP:0012439)1.49707839

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK6.89650830
2ERN14.81845482
3FGFR44.73564586
4SIK14.39153417
5TAOK33.15071357
6ERBB43.01613177
7INSRR2.99169195
8MAP2K42.29691042
9PRPF4B2.26572884
10OBSCN2.24746079
11NTRK32.21146667
12MST1R2.13624703
13PKN22.11471201
14TRIB31.92693800
15MAPK111.91249360
16FLT31.78687819
17PIK3CG1.76878056
18TYK21.76486405
19LATS11.73901998
20DAPK21.58215624
21PTK61.55899442
22NEK91.44937951
23TNK21.44002682
24FGFR21.43743270
25ABL21.41191263
26FRK1.36216287
27KDR1.31156880
28NLK1.30406268
29JAK21.26991718
30ZAP701.21954685
31MAP3K71.18933082
32JAK11.11085199
33ERBB21.10726619
34PRKAA21.09765852
35EPHB11.07671988
36EPHA31.05471591
37TBK11.05166520
38MAP2K31.05094656
39GRK61.02154795
40PINK11.02146017
41BLK0.99842087
42MAPK40.96512867
43MAP3K140.93151764
44PDK20.91807264
45MAP3K100.90998165
46MET0.88859426
47PRKCZ0.88785363
48PRKG10.88106634
49TIE10.87785915
50MAP3K20.85937556
51MAP3K30.85210044
52STK38L0.80655973
53CDK60.79632623
54MAPK150.78727409
55CAMK1D0.78055008
56MAPK120.77441956
57FER0.76753389
58MAP3K110.75219683
59PRKACG0.75087732
60RIPK10.74104866
61PRKACA0.73622525
62CAMK2G0.70740775
63CSK0.70198791
64GSK3A0.69168661
65FGFR30.68944559
66DYRK1B0.67842129
67MAP4K10.67839070
68TGFBR20.66531696
69CAMKK20.64184300
70PHKG20.63870800
71PHKG10.63870800
72PRKAA10.63167829
73SGK30.62083861
74MAP2K60.60556740
75KSR20.60284621
76MAPKAPK30.58913242
77IRAK30.57036544
78MAPK70.56171392
79IKBKE0.56048551
80PTK20.55380697
81CSF1R0.54731952
82STK380.52845265
83PDPK10.50181375
84PRKCQ0.47770441
85RPS6KA30.47622477
86PRKACB0.47258414
87CSNK1D0.47252057
88PKN10.45330926
89MAP2K10.45188228
90SGK20.44991714
91PRKCB0.44690970
92CSNK1G10.44425958
93RET0.44256074
94MAP3K50.43985328
95GRK10.43861080
96IGF1R0.42616131
97MYLK0.42338572
98EPHA40.39778794
99TTN0.39354254
100MAP3K130.39231742
101ICK0.38522733
102MTOR0.38088008
103TAOK20.37862335
104CDK40.37750585
105SGK10.37408708
106MUSK0.37312212
107EGFR0.37049715
108CAMKK10.35984392
109PRKCG0.35702566
110MAP3K60.35508880
111CSNK1E0.34028221
112IRAK10.33605666
113MAP3K10.32345620
114JAK30.32251486
115CAMK40.31736236
116SGK4940.30876011
117SGK2230.30876011
118CAMK1G0.30111628
119PDK10.28849773
120LATS20.26934836
121MAP2K20.23649521
122PRKCA0.23362915
123ABL10.23161598
124BMX0.22692272
125CSNK1G20.22445247
126PBK0.21747372
127PIK3CA0.21347179
128PAK30.20118953
129IRAK20.19016664
130CSNK1G30.18860989

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001204.51703150
2Nitrogen metabolism_Homo sapiens_hsa009103.74875092
3Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.44197812
4Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.31371323
5Arginine biosynthesis_Homo sapiens_hsa002203.11250095
6Complement and coagulation cascades_Homo sapiens_hsa046102.94896848
7Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.68621746
8Tryptophan metabolism_Homo sapiens_hsa003802.65339665
9Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.61120510
10Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.54892867
11Fatty acid degradation_Homo sapiens_hsa000712.46638257
12Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.34807306
13Pentose and glucuronate interconversions_Homo sapiens_hsa000402.20879238
14Butanoate metabolism_Homo sapiens_hsa006502.10858073
15Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.09540987
16Peroxisome_Homo sapiens_hsa041462.04698723
17Chemical carcinogenesis_Homo sapiens_hsa052041.91381433
18Staphylococcus aureus infection_Homo sapiens_hsa051501.90732718
19Propanoate metabolism_Homo sapiens_hsa006401.90009659
20Histidine metabolism_Homo sapiens_hsa003401.89425890
21Steroid hormone biosynthesis_Homo sapiens_hsa001401.88355057
22Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.87622913
23PPAR signaling pathway_Homo sapiens_hsa033201.86873769
24Fatty acid metabolism_Homo sapiens_hsa012121.80012880
25Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.75599534
26Drug metabolism - other enzymes_Homo sapiens_hsa009831.74656487
27Caffeine metabolism_Homo sapiens_hsa002321.69595140
28beta-Alanine metabolism_Homo sapiens_hsa004101.68573551
29Retinol metabolism_Homo sapiens_hsa008301.65722392
30Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.63845773
31Selenocompound metabolism_Homo sapiens_hsa004501.58800285
32Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.57109820
33Phenylalanine metabolism_Homo sapiens_hsa003601.56251080
342-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.51313405
35Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.50410157
36Bile secretion_Homo sapiens_hsa049761.49656991
37Tyrosine metabolism_Homo sapiens_hsa003501.43164089
38Pyruvate metabolism_Homo sapiens_hsa006201.33609301
39Cysteine and methionine metabolism_Homo sapiens_hsa002701.32255070
40Sulfur metabolism_Homo sapiens_hsa009201.30562356
41Fatty acid elongation_Homo sapiens_hsa000621.29095583
42Starch and sucrose metabolism_Homo sapiens_hsa005001.26335043
43ABC transporters_Homo sapiens_hsa020101.22624657
44Steroid biosynthesis_Homo sapiens_hsa001001.21507548
45Biosynthesis of amino acids_Homo sapiens_hsa012301.20876288
46Fat digestion and absorption_Homo sapiens_hsa049751.20664512
47Folate biosynthesis_Homo sapiens_hsa007901.19299578
48Carbon metabolism_Homo sapiens_hsa012001.11467945
49Maturity onset diabetes of the young_Homo sapiens_hsa049501.03217189
50Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.01025173
51Cyanoamino acid metabolism_Homo sapiens_hsa004600.98551312
52Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.96755889
53Arginine and proline metabolism_Homo sapiens_hsa003300.94467304
54Vitamin B6 metabolism_Homo sapiens_hsa007500.93009524
55Sulfur relay system_Homo sapiens_hsa041220.92041702
56Vitamin digestion and absorption_Homo sapiens_hsa049770.88554983
57Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.87628213
58Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.85215779
59Lysine degradation_Homo sapiens_hsa003100.79879191
60One carbon pool by folate_Homo sapiens_hsa006700.75739119
61Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.68568296
62Glycerolipid metabolism_Homo sapiens_hsa005610.67933237
63Glutathione metabolism_Homo sapiens_hsa004800.62465413
64Pentose phosphate pathway_Homo sapiens_hsa000300.58186689
65Fatty acid biosynthesis_Homo sapiens_hsa000610.54867324
66Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.45118795
67Metabolic pathways_Homo sapiens_hsa011000.44634294
68Prion diseases_Homo sapiens_hsa050200.39416781
69Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.39318521
70alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.25735223
71Insulin resistance_Homo sapiens_hsa049310.24930674
72Adipocytokine signaling pathway_Homo sapiens_hsa049200.24318459
73Fructose and mannose metabolism_Homo sapiens_hsa000510.23700127
74Galactose metabolism_Homo sapiens_hsa000520.23405552
75Linoleic acid metabolism_Homo sapiens_hsa005910.19979350
76Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.18075747
77Glycerophospholipid metabolism_Homo sapiens_hsa005640.16477963
78Glucagon signaling pathway_Homo sapiens_hsa049220.10528711
79Other glycan degradation_Homo sapiens_hsa005110.08050947
80AMPK signaling pathway_Homo sapiens_hsa041520.02892186
81FoxO signaling pathway_Homo sapiens_hsa04068-0.2603721
82Sphingolipid metabolism_Homo sapiens_hsa00600-0.2590488
83Longevity regulating pathway - multiple species_Homo sapiens_hsa04213-0.2299262
84Carbohydrate digestion and absorption_Homo sapiens_hsa04973-0.2254745
85Bladder cancer_Homo sapiens_hsa05219-0.2250102
86Amoebiasis_Homo sapiens_hsa05146-0.2221016
87Pertussis_Homo sapiens_hsa05133-0.2209759
88Type II diabetes mellitus_Homo sapiens_hsa04930-0.2171816
89Thyroid hormone synthesis_Homo sapiens_hsa04918-0.1897259
90Arachidonic acid metabolism_Homo sapiens_hsa00590-0.1834387
91Vascular smooth muscle contraction_Homo sapiens_hsa04270-0.1802881
92Renin-angiotensin system_Homo sapiens_hsa04614-0.1695892
93Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141-0.1663140
94Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604-0.1634839
95Glycosaminoglycan degradation_Homo sapiens_hsa00531-0.1529804
96Circadian rhythm_Homo sapiens_hsa04710-0.1519506
97Central carbon metabolism in cancer_Homo sapiens_hsa05230-0.1495215
98Hepatitis C_Homo sapiens_hsa05160-0.1493324
99Regulation of autophagy_Homo sapiens_hsa04140-0.1470452
100African trypanosomiasis_Homo sapiens_hsa05143-0.1324526
101Systemic lupus erythematosus_Homo sapiens_hsa05322-0.1136212
102Insulin signaling pathway_Homo sapiens_hsa04910-0.0946206
103Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520-0.0864551
104Mineral absorption_Homo sapiens_hsa04978-0.0733111
105Ovarian steroidogenesis_Homo sapiens_hsa04913-0.0720561
106Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534-0.0586467
107Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932-0.0579876
108Serotonergic synapse_Homo sapiens_hsa04726-0.0268964

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