ITIH5

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a heavy chain component of one of the inter-alpha-trypsin inhibitor (ITI) family members. ITI proteins are involved in extracellular matrix stabilization and in the prevention of tumor metastasis. They are also structurally related plasma serine protease inhibitors and are composed of a light chain and varying numbers of heavy chains. This family member is thought to function as a tumor suppressor in breast and thyroid cancers. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1retina vasculature morphogenesis in camera-type eye (GO:0061299)5.01866248
2protein heterotrimerization (GO:0070208)4.81154740
3epoxygenase P450 pathway (GO:0019373)4.75660201
4lymph vessel development (GO:0001945)4.14065938
5low-density lipoprotein particle clearance (GO:0034383)4.11388601
6transcytosis (GO:0045056)4.10780501
7positive regulation of fatty acid beta-oxidation (GO:0032000)4.04901867
8collagen fibril organization (GO:0030199)3.96046664
9cGMP-mediated signaling (GO:0019934)3.95614002
10negative regulation of smooth muscle cell migration (GO:0014912)3.87600061
11negative regulation of protein autophosphorylation (GO:0031953)3.84618820
12positive regulation of fatty acid oxidation (GO:0046321)3.82728398
13collagen metabolic process (GO:0032963)3.82048741
14collagen catabolic process (GO:0030574)3.74385847
15triglyceride catabolic process (GO:0019433)3.72647065
16multicellular organismal macromolecule metabolic process (GO:0044259)3.71593119
17brown fat cell differentiation (GO:0050873)3.71258230
18omega-hydroxylase P450 pathway (GO:0097267)3.69019760
19positive regulation of cellular response to insulin stimulus (GO:1900078)3.68352323
20keratan sulfate catabolic process (GO:0042340)3.67679455
21regulation of platelet-derived growth factor receptor signaling pathway (GO:0010640)3.66239648
22basement membrane organization (GO:0071711)3.65234855
23biotin metabolic process (GO:0006768)3.64995724
24positive regulation of phosphoprotein phosphatase activity (GO:0032516)3.64852116
25multicellular organismal metabolic process (GO:0044236)3.59614501
26cell proliferation involved in metanephros development (GO:0072203)3.59193958
27positive regulation of glomerulus development (GO:0090193)3.58084370
28diacylglycerol metabolic process (GO:0046339)3.57012266
29phagocytosis, recognition (GO:0006910)3.55604932
30endothelial cell chemotaxis (GO:0035767)3.55404003
31regulation of sequestering of triglyceride (GO:0010889)3.51084049
32ovulation from ovarian follicle (GO:0001542)3.48288489
33multicellular organismal catabolic process (GO:0044243)3.45793911
34myelination in peripheral nervous system (GO:0022011)3.45530029
35peripheral nervous system axon ensheathment (GO:0032292)3.45530029
36acylglycerol catabolic process (GO:0046464)3.39762655
37neutral lipid catabolic process (GO:0046461)3.39762655
38positive regulation of metanephros development (GO:0072216)3.39185799
39positive regulation of insulin receptor signaling pathway (GO:0046628)3.38653358
40cell migration involved in heart development (GO:0060973)3.32710140
41tyrosine phosphorylation of STAT protein (GO:0007260)3.28179584
42white fat cell differentiation (GO:0050872)3.26559273
43gamma-aminobutyric acid transport (GO:0015812)3.21648371
44regulation of steroid hormone biosynthetic process (GO:0090030)3.19690151
45dermatan sulfate biosynthetic process (GO:0030208)3.19329490
46regulation of lipoprotein metabolic process (GO:0050746)3.18230700
47negative regulation of platelet-derived growth factor receptor signaling pathway (GO:0010642)3.16698238
48positive regulation of glycogen biosynthetic process (GO:0045725)3.15698435
49regulation of glycogen (starch) synthase activity (GO:2000465)3.14189148
50ethanol oxidation (GO:0006069)3.10192121
51establishment of tissue polarity (GO:0007164)3.09256015
52establishment of planar polarity (GO:0001736)3.09256015
53positive regulation of extracellular matrix organization (GO:1903055)3.06187434
54negative regulation of macrophage derived foam cell differentiation (GO:0010745)3.05852551
55regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)3.04877696
56response to dietary excess (GO:0002021)3.03947054
57valine metabolic process (GO:0006573)3.03814879
58metanephric mesenchyme development (GO:0072075)3.03516762
59negative regulation of cartilage development (GO:0061037)3.01720819
60dermatan sulfate metabolic process (GO:0030205)3.00601564
61negative regulation of chondrocyte differentiation (GO:0032331)2.99421114
62positive regulation of lipid storage (GO:0010884)2.97536751
63extracellular matrix disassembly (GO:0022617)2.96671044
64cellular response to vitamin (GO:0071295)2.94259990
65regulation of somitogenesis (GO:0014807)2.92263878
66glomerular filtration (GO:0003094)2.90287758
67negative regulation of amino acid transport (GO:0051956)2.88764925
68plasma lipoprotein particle clearance (GO:0034381)2.87112594
69positive regulation of protein kinase C signaling (GO:0090037)2.86768195
70cellular response to epinephrine stimulus (GO:0071872)2.85934795
71negative regulation of smooth muscle cell proliferation (GO:0048662)2.83565286
72polyol transport (GO:0015791)2.83399176
73positive regulation of cholesterol efflux (GO:0010875)2.82335512
74regulation of macrophage derived foam cell differentiation (GO:0010743)2.81500884
75negative regulation of appetite (GO:0032099)2.80540055
76negative regulation of response to food (GO:0032096)2.80540055
77positive regulation of hormone biosynthetic process (GO:0046886)2.80454808
78regulation of cAMP-dependent protein kinase activity (GO:2000479)2.80017412
79extracellular fibril organization (GO:0043206)2.79673239
80regulation of fatty acid beta-oxidation (GO:0031998)2.79017255
81cellular response to vascular endothelial growth factor stimulus (GO:0035924)2.78725681
82negative regulation of metanephros development (GO:0072217)2.78225326
83definitive hemopoiesis (GO:0060216)2.77053569
84fatty acid transmembrane transport (GO:1902001)2.76996023
85cardiac muscle cell proliferation (GO:0060038)2.76848819
86negative regulation of macrophage differentiation (GO:0045650)2.76670543
87positive regulation of endothelial cell apoptotic process (GO:2000353)2.74564063
88endothelial cell morphogenesis (GO:0001886)2.74502656
89cAMP biosynthetic process (GO:0006171)2.74125586
90regulation of cholesterol storage (GO:0010885)2.74090336
91growth hormone receptor signaling pathway (GO:0060396)2.73358204
92mesenchyme morphogenesis (GO:0072132)2.72868241
93exocrine pancreas development (GO:0031017)2.71902807
94adult feeding behavior (GO:0008343)2.71421317
95complement activation, alternative pathway (GO:0006957)2.70837851
96retinol metabolic process (GO:0042572)2.69112021
97lipid storage (GO:0019915)2.69071126
98endocrine hormone secretion (GO:0060986)2.68603979
99embryonic camera-type eye morphogenesis (GO:0048596)2.65367099
100mesonephros development (GO:0001823)2.65240393
101positive regulation of macrophage cytokine production (GO:0060907)2.63574730
102positive regulation of glycogen metabolic process (GO:0070875)2.62936465
103cAMP catabolic process (GO:0006198)2.61786455
104positive regulation of glucose import (GO:0046326)2.61759628
105glomerular basement membrane development (GO:0032836)2.60218171
106somite development (GO:0061053)2.60134641
107peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)2.58688902
108kidney mesenchyme development (GO:0072074)2.57599306
109regulation of fatty acid oxidation (GO:0046320)2.57323851
110pattern specification involved in kidney development (GO:0061004)2.56708476
111primary alcohol metabolic process (GO:0034308)2.55856250
112positive regulation of glycolytic process (GO:0045821)2.55458711
113positive regulation of cholesterol transport (GO:0032376)2.55358078
114positive regulation of sterol transport (GO:0032373)2.55358078
115fatty acid beta-oxidation (GO:0006635)2.55237070
116negative regulation of tumor necrosis factor-mediated signaling pathway (GO:0010804)2.54709193
117negative regulation of granulocyte differentiation (GO:0030853)2.53981726
118lipid particle organization (GO:0034389)2.53215011
119fatty acid homeostasis (GO:0055089)2.52390790
120cyclic nucleotide catabolic process (GO:0009214)2.52274873
121carnitine shuttle (GO:0006853)2.52104976
122regulation of branching involved in prostate gland morphogenesis (GO:0060687)2.52056922
123cellular response to leptin stimulus (GO:0044320)2.51853961
124regulation of metanephros development (GO:0072215)2.51512995
125smooth muscle tissue development (GO:0048745)2.48953683
126cAMP metabolic process (GO:0046058)2.46997234
127negative regulation of catenin import into nucleus (GO:0035414)2.46911148
128blood vessel maturation (GO:0001955)2.46527267
129positive regulation of fatty acid metabolic process (GO:0045923)2.45825970
130renal filtration (GO:0097205)2.44618214
131cellular response to growth hormone stimulus (GO:0071378)2.44188403
132type B pancreatic cell proliferation (GO:0044342)2.43751802
133vascular endothelial growth factor signaling pathway (GO:0038084)2.43727517
134cell-matrix adhesion (GO:0007160)2.43605467
135positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.43599324
136cGMP biosynthetic process (GO:0006182)2.43147852
137type B pancreatic cell development (GO:0003323)2.41693828
138cellular sodium ion homeostasis (GO:0006883)2.41594761
139regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition 2.41587578
140regulation of gonadotropin secretion (GO:0032276)2.41369752
141regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)2.41267961
142fibril organization (GO:0097435)2.41096762
143cyclic purine nucleotide metabolic process (GO:0052652)2.39910515
144glycerol metabolic process (GO:0006071)2.39657793
145neuron projection extension involved in neuron projection guidance (GO:1902284)2.38394136
146axon extension involved in axon guidance (GO:0048846)2.38394136
147negative regulation of gluconeogenesis (GO:0045721)2.38114783
148response to epinephrine (GO:0071871)2.37497389
149cyclic nucleotide biosynthetic process (GO:0009190)2.37410899
150regulation of glomerulus development (GO:0090192)2.36816606
151positive regulation of macrophage derived foam cell differentiation (GO:0010744)2.36334838
152extracellular matrix organization (GO:0030198)2.36303113
153glial cell migration (GO:0008347)2.36256359
154embryonic digestive tract development (GO:0048566)2.35791277
155glycerolipid catabolic process (GO:0046503)2.35689690
156endocardial cushion morphogenesis (GO:0003203)2.35237084
157extracellular structure organization (GO:0043062)2.35192526
158leukocyte tethering or rolling (GO:0050901)2.34949167
159regulation of lipid storage (GO:0010883)2.34920056
160cell proliferation involved in kidney development (GO:0072111)2.34318048

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.64524593
2TRIM28_21343339_ChIP-Seq_HEK293_Human4.00412441
3CLOCK_20551151_ChIP-Seq_293T_Human2.81523623
4ESR1_22446102_ChIP-Seq_UTERUS_Mouse2.59868798
5TP63_17297297_ChIP-ChIP_HaCaT_Human2.59680765
6EZH2_22144423_ChIP-Seq_EOC_Human2.56054441
7TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.14760654
8GATA1_22025678_ChIP-Seq_K562_Human2.11539096
9EED_16625203_ChIP-ChIP_MESCs_Mouse2.11509279
10SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.09814359
11SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.08986609
12EZH2_18974828_ChIP-Seq_MESCs_Mouse2.08803865
13RNF2_18974828_ChIP-Seq_MESCs_Mouse2.08803865
14CDX2_19796622_ChIP-Seq_MESCs_Mouse1.92580827
15EP300_21415370_ChIP-Seq_HL-1_Mouse1.91952624
16SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.87749556
17PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.79165773
18JARID2_20064375_ChIP-Seq_MESCs_Mouse1.77919334
19* BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.75960453
20SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.75279503
21GATA2_21666600_ChIP-Seq_HMVEC_Human1.72873494
22SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.70106781
23RARG_19884340_ChIP-ChIP_MEFs_Mouse1.68288903
24CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.67899272
25ESR1_21235772_ChIP-Seq_MCF-7_Human1.65939079
26ESR2_21235772_ChIP-Seq_MCF-7_Human1.62610667
27JARID2_20075857_ChIP-Seq_MESCs_Mouse1.60771900
28PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.59629405
29TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.59590397
30CJUN_26792858_Chip-Seq_BT549_Human1.58895189
31MTF2_20144788_ChIP-Seq_MESCs_Mouse1.53735867
32TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.53279886
33PPAR_26484153_Chip-Seq_NCI-H1993_Human1.52473373
34PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.52118044
35ZNF217_24962896_ChIP-Seq_MCF-7_Human1.50738296
36RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.49302821
37VDR_22108803_ChIP-Seq_LS180_Human1.47350183
38SMAD_19615063_ChIP-ChIP_OVARY_Human1.46317572
39LXR_22158963_ChIP-Seq_LIVER_Mouse1.45476430
40GBX2_23144817_ChIP-Seq_PC3_Human1.44253511
41EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.42875407
42CBX2_27304074_Chip-Seq_ESCs_Mouse1.42542799
43ZFP57_27257070_Chip-Seq_ESCs_Mouse1.41778593
44RNF2_27304074_Chip-Seq_ESCs_Mouse1.40711299
45FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.39188555
46GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.38004016
47CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.36116981
48RXR_22108803_ChIP-Seq_LS180_Human1.33663467
49CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.33662405
50EZH2_27304074_Chip-Seq_ESCs_Mouse1.29457529
51TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.27064307
52PIAS1_25552417_ChIP-Seq_VCAP_Human1.26358130
53RXR_22158963_ChIP-Seq_LIVER_Mouse1.25055241
54FOXO3_23340844_ChIP-Seq_DLD1_Human1.24725585
55AHR_22903824_ChIP-Seq_MCF-7_Human1.23349977
56* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.23176915
57NRF2_20460467_ChIP-Seq_MEFs_Mouse1.21401177
58NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.21401177
59STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.21032442
60NR3C1_23031785_ChIP-Seq_PC12_Mouse1.20986375
61NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.20338572
62MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.20163004
63CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.18898151
64DROSHA_22980978_ChIP-Seq_HELA_Human1.18451236
65ARNT_22903824_ChIP-Seq_MCF-7_Human1.18078455
66WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.18039781
67VDR_24787735_ChIP-Seq_THP-1_Human1.17758138
68SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.16074925
69SOX9_24532713_ChIP-Seq_HFSC_Mouse1.15471614
70PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.14805048
71STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.13010979
72TP53_20018659_ChIP-ChIP_R1E_Mouse1.12200543
73PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.12095959
74TP53_16413492_ChIP-PET_HCT116_Human1.11264450
75THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.11192997
76EZH2_27294783_Chip-Seq_ESCs_Mouse1.10862950
77RUNX_20019798_ChIP-Seq_JUKART_Human1.08917039
78ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.07320823
79BMI1_23680149_ChIP-Seq_NPCS_Mouse1.06652148
80WT1_19549856_ChIP-ChIP_CCG9911_Human1.05477694
81PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.04829000
82SOX2_20726797_ChIP-Seq_SW620_Human1.03888046
83TP53_18474530_ChIP-ChIP_U2OS_Human1.03851634
84SUZ12_27294783_Chip-Seq_ESCs_Mouse1.03784501
85GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.02882294
86TBX20_22328084_ChIP-Seq_HEART_Mouse1.02027955
87TBX20_22080862_ChIP-Seq_HEART_Mouse1.02027955
88TCF4_18268006_ChIP-ChIP_LS174T_Human1.00032653
89CTNNB1_20460455_ChIP-Seq_HCT116_Human0.99966311
90RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.99915467
91TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.99758575
92* TOP2B_26459242_ChIP-Seq_MCF-7_Human0.99565928
93AR_21572438_ChIP-Seq_LNCaP_Human0.99095852
94CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons0.98957704
95SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.98841788
96GATA1_19941826_ChIP-Seq_K562_Human0.96737012
97MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.96361534
98NR3C1_21868756_ChIP-Seq_MCF10A_Human0.94925525
99BCAT_22108803_ChIP-Seq_LS180_Human0.94829334
100AR_25329375_ChIP-Seq_VCAP_Human0.94770862
101KDM2B_26808549_Chip-Seq_SUP-B15_Human0.94049005
102CTBP2_25329375_ChIP-Seq_LNCAP_Human0.93889766
103RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.93667872
104SA1_22415368_ChIP-Seq_MEFs_Mouse0.93580025
105* SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.92372944
106ESR1_20079471_ChIP-ChIP_T-47D_Human0.91772230
107P300_19829295_ChIP-Seq_ESCs_Human0.91626968
108FOXA2_19822575_ChIP-Seq_HepG2_Human0.90965853
109RAD21_21589869_ChIP-Seq_MESCs_Mouse0.90448143
110NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.90438464
111ISL1_27105846_Chip-Seq_CPCs_Mouse0.89982029
112RING1B_27294783_Chip-Seq_ESCs_Mouse0.89902437
113SMAD4_21799915_ChIP-Seq_A2780_Human0.88834637
114* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.88653463
115OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.88089101
116ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.87818234
117RNF2_27304074_Chip-Seq_NSC_Mouse0.87204947
118CDX2_20551321_ChIP-Seq_CACO-2_Human0.86660833
119CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.86606048
120HIF1A_21447827_ChIP-Seq_MCF-7_Human0.86053510
121PPARA_22158963_ChIP-Seq_LIVER_Mouse0.85620667
122SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.85566314
123ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.85424215
124RBPJ_22232070_ChIP-Seq_NCS_Mouse0.85301609
125SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.84554286
126GATA2_19941826_ChIP-Seq_K562_Human0.84499693
127* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.83748147
128* STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.82451417
129* KDM2B_26808549_Chip-Seq_REH_Human0.81173139
130EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.80600763
131* PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.79167825
132SMAD3_21741376_ChIP-Seq_EPCs_Human0.78407392

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen7.20100940
2MP0005275_abnormal_skin_tensile5.05614853
3MP0005670_abnormal_white_adipose4.86560511
4MP0004272_abnormal_basement_membrane4.14508762
5MP0005503_abnormal_tendon_morphology3.32186311
6MP0004130_abnormal_muscle_cell2.93930345
7MP0005666_abnormal_adipose_tissue2.85909957
8MP0001879_abnormal_lymphatic_vessel2.47279884
9MP0001958_emphysema2.45178834
10MP0005375_adipose_tissue_phenotype2.36284800
11MP0003011_delayed_dark_adaptation2.35551528
12MP0000013_abnormal_adipose_tissue2.19733573
13MP0000751_myopathy2.14143664
14MP0005167_abnormal_blood-brain_barrier2.01212666
15MP0000003_abnormal_adipose_tissue1.96526021
16MP0003828_pulmonary_edema1.84498876
17MP0004185_abnormal_adipocyte_glucose1.83425366
18MP0003279_aneurysm1.82801583
19MP0002166_altered_tumor_susceptibility1.76757689
20MP0002060_abnormal_skin_morphology1.74894115
21MP0003045_fibrosis1.72451858
22MP0002108_abnormal_muscle_morphology1.70976637
23MP0003705_abnormal_hypodermis_morpholog1.65118647
24MP0002249_abnormal_larynx_morphology1.61485494
25MP0002837_dystrophic_cardiac_calcinosis1.58555256
26MP0010329_abnormal_lipoprotein_level1.53903033
27MP0003690_abnormal_glial_cell1.53420652
28MP0003136_yellow_coat_color1.53275444
29MP0003283_abnormal_digestive_organ1.52737629
30MP0002909_abnormal_adrenal_gland1.51385223
31MP0002006_tumorigenesis1.51011071
32MP0002971_abnormal_brown_adipose1.50765725
33MP0002638_abnormal_pupillary_reflex1.49887091
34MP0002009_preneoplasia1.46179202
35MP0005448_abnormal_energy_balance1.44066894
36MP0001661_extended_life_span1.43581948
37MP0009115_abnormal_fat_cell1.41902402
38MP0009780_abnormal_chondrocyte_physiolo1.41055689
39MP0002254_reproductive_system_inflammat1.38390762
40MP0000534_abnormal_ureter_morphology1.36227625
41MP0010368_abnormal_lymphatic_system1.33004648
42MP0003724_increased_susceptibility_to1.31068467
43MP0005623_abnormal_meninges_morphology1.28343234
44MP0005508_abnormal_skeleton_morphology1.27695657
45MP0000230_abnormal_systemic_arterial1.27103726
46MP0009384_cardiac_valve_regurgitation1.25076116
47MP0002938_white_spotting1.23784619
48MP0005377_hearing/vestibular/ear_phenot1.20927869
49MP0003878_abnormal_ear_physiology1.20927869
50MP0004147_increased_porphyrin_level1.17806398
51MP0002168_other_aberrant_phenotype1.15864140
52MP0003879_abnormal_hair_cell1.14726603
53MP0003385_abnormal_body_wall1.14502603
54MP0005379_endocrine/exocrine_gland_phen1.12548039
55MP0000750_abnormal_muscle_regeneration1.10715705
56MP0002295_abnormal_pulmonary_circulatio1.09346981
57MP0006138_congestive_heart_failure1.08263622
58MP0003941_abnormal_skin_development1.06867758
59MP0002876_abnormal_thyroid_physiology1.04886477
60MP0005164_abnormal_response_to1.04451559
61MP0002933_joint_inflammation1.04419985
62MP0005334_abnormal_fat_pad1.03761313
63MP0004215_abnormal_myocardial_fiber1.03081509
64MP0005452_abnormal_adipose_tissue1.02031982
65MP0003186_abnormal_redox_activity1.00720045
66MP0006054_spinal_hemorrhage0.98949246
67MP0006276_abnormal_autonomic_nervous0.98269225
68MP0003191_abnormal_cellular_cholesterol0.97105841
69MP0000749_muscle_degeneration0.95641206
70MP0009250_abnormal_appendicular_skeleto0.95369911
71MP0005171_absent_coat_pigmentation0.93878634
72MP0002118_abnormal_lipid_homeostasis0.93810058
73MP0003868_abnormal_feces_composition0.93256084
74MP0005388_respiratory_system_phenotype0.92749002
75MP0002133_abnormal_respiratory_system0.92749002
76MP0004036_abnormal_muscle_relaxation0.92631781
77MP0005595_abnormal_vascular_smooth0.89382988
78MP0002970_abnormal_white_adipose0.87413924
79MP0005248_abnormal_Harderian_gland0.85831252
80MP0004084_abnormal_cardiac_muscle0.85338069
81MP0008775_abnormal_heart_ventricle0.84151187
82MP0000163_abnormal_cartilage_morphology0.83380724
83MP0000343_altered_response_to0.81415526
84MP0003566_abnormal_cell_adhesion0.80941687
85MP0002115_abnormal_skeleton_extremities0.79543034
86MP0005620_abnormal_muscle_contractility0.78764117
87MP0000759_abnormal_skeletal_muscle0.77184156
88MP0003567_abnormal_fetal_cardiomyocyte0.77160609
89MP0002128_abnormal_blood_circulation0.76618779
90MP0004145_abnormal_muscle_electrophysio0.76159428
91MP0002078_abnormal_glucose_homeostasis0.74635760
92MP0001501_abnormal_sleep_pattern0.73969145
93MP0000767_abnormal_smooth_muscle0.73616441
94MP0002932_abnormal_joint_morphology0.73562168
95MP0004264_abnormal_extraembryonic_tissu0.73230416
96MP0003942_abnormal_urinary_system0.73063411
97MP0004087_abnormal_muscle_fiber0.72899505
98MP0001270_distended_abdomen0.72603785
99MP0003950_abnormal_plasma_membrane0.72031299
100MP0005390_skeleton_phenotype0.71986359
101MP0003115_abnormal_respiratory_system0.71928079
102MP0001963_abnormal_hearing_physiology0.71292790
103MP0004085_abnormal_heartbeat0.70147830
104MP0003137_abnormal_impulse_conducting0.69985219
105MP0005535_abnormal_body_temperature0.68844349
106MP0002089_abnormal_postnatal_growth/wei0.68462676
107MP0005369_muscle_phenotype0.66236960
108MP0002896_abnormal_bone_mineralization0.66011526
109MP0001614_abnormal_blood_vessel0.65453212
110MP0001542_abnormal_bone_strength0.64468937
111MP0003195_calcinosis0.64431689
112MP0002998_abnormal_bone_remodeling0.64394454
113MP0002972_abnormal_cardiac_muscle0.63622950
114MP0005385_cardiovascular_system_phenoty0.62047228
115MP0001544_abnormal_cardiovascular_syste0.62047228
116MP0005647_abnormal_sex_gland0.61524572
117MP0003646_muscle_fatigue0.61103107
118MP0000049_abnormal_middle_ear0.59715409
119MP0003953_abnormal_hormone_level0.59544939
120MP0000467_abnormal_esophagus_morphology0.58923143
121MP0004858_abnormal_nervous_system0.58520982
122MP0003948_abnormal_gas_homeostasis0.58181146
123MP0004134_abnormal_chest_morphology0.57198699
124MP0010630_abnormal_cardiac_muscle0.57106707
125MP0001664_abnormal_digestion0.56357252
126MP0001533_abnormal_skeleton_physiology0.56086547
127MP0003959_abnormal_lean_body0.55904822
128MP0000249_abnormal_blood_vessel0.55318933
129MP0005023_abnormal_wound_healing0.55293310
130MP0005165_increased_susceptibility_to0.54987728
131MP0004019_abnormal_vitamin_homeostasis0.54221608
132MP0005551_abnormal_eye_electrophysiolog0.54044845
133MP0001502_abnormal_circadian_rhythm0.53911291
134MP0001485_abnormal_pinna_reflex0.52527222
135MP0000538_abnormal_urinary_bladder0.51635827

Predicted human phenotypes

RankGene SetZ-score
1Follicular hyperkeratosis (HP:0007502)6.64046097
2Broad metatarsal (HP:0001783)5.18693669
3Ankle contracture (HP:0006466)4.59849440
4Soft skin (HP:0000977)4.40892182
5Protrusio acetabuli (HP:0003179)4.37354882
6Aortic dissection (HP:0002647)4.19312298
7Cerebral aneurysm (HP:0004944)4.16798814
8Prominent supraorbital ridges (HP:0000336)3.91932575
9Bladder diverticulum (HP:0000015)3.86315613
10Hypoplasia of the iris (HP:0007676)3.77148992
11Premature rupture of membranes (HP:0001788)3.66885004
12Acanthosis nigricans (HP:0000956)3.49939783
13Type 1 muscle fiber predominance (HP:0003803)3.36436128
14Mitral valve prolapse (HP:0001634)3.36190127
15Increased variability in muscle fiber diameter (HP:0003557)3.33191252
16Oligomenorrhea (HP:0000876)3.25094788
17Increased connective tissue (HP:0009025)3.14747383
18Ulnar claw (HP:0001178)3.14026179
19Aortic aneurysm (HP:0004942)3.09268345
20Spinal rigidity (HP:0003306)3.05496290
21Asymmetry of the thorax (HP:0001555)3.02282654
22Alopecia of scalp (HP:0002293)2.99746182
23Abnormality of skeletal muscle fiber size (HP:0012084)2.97715595
24Hypertriglyceridemia (HP:0002155)2.95539231
25Shallow orbits (HP:0000586)2.90734010
26Fragile skin (HP:0001030)2.89816525
27Atrophic scars (HP:0001075)2.85192975
28Hemiplegia (HP:0002301)2.75917560
29Short hallux (HP:0010109)2.75066259
30Complement deficiency (HP:0004431)2.68801219
31Buphthalmos (HP:0000557)2.66890603
32Overgrowth (HP:0001548)2.61671221
33Striae distensae (HP:0001065)2.61546201
34Nephritis (HP:0000123)2.60206781
35Hyperextensible skin (HP:0000974)2.59530961
36Arterial tortuosity (HP:0005116)2.56478017
37Vascular tortuosity (HP:0004948)2.55229827
38Abnormal eating behavior (HP:0100738)2.54881807
39Facial diplegia (HP:0001349)2.54244104
40Pigmentary retinal degeneration (HP:0001146)2.54200467
41Large for gestational age (HP:0001520)2.53056585
42Aplasia/Hypoplasia of the hallux (HP:0008362)2.50024057
43Segmental peripheral demyelination/remyelination (HP:0003481)2.48301254
44Stridor (HP:0010307)2.42762594
45Action tremor (HP:0002345)2.41188460
46Slender build (HP:0001533)2.41180849
47Hypoplastic ischia (HP:0003175)2.40875287
48Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.39700962
49Adactyly (HP:0009776)2.39661988
50Hyperglycinuria (HP:0003108)2.39079070
51Insulin resistance (HP:0000855)2.38673755
52Epiphyseal dysplasia (HP:0002656)2.36811244
53Neonatal short-limb short stature (HP:0008921)2.36430029
54Axonal loss (HP:0003447)2.30654352
55Dilatation of the ascending aorta (HP:0005111)2.30161553
56Bone cyst (HP:0012062)2.29424248
57Hydroxyprolinuria (HP:0003080)2.26820675
58Abnormality of proline metabolism (HP:0010907)2.26820675
59Hypoventilation (HP:0002791)2.25841946
60Aortic valve stenosis (HP:0001650)2.25679400
61Myocardial infarction (HP:0001658)2.25402600
62Venous insufficiency (HP:0005293)2.24791887
63Severe Myopia (HP:0011003)2.24106908
64Spondylolisthesis (HP:0003302)2.21155848
65Abnormality of complement system (HP:0005339)2.17246687
66Abnormal hemoglobin (HP:0011902)2.15595891
67Broad ribs (HP:0000885)2.14000498
68Vertebral compression fractures (HP:0002953)2.12748239
69Hip contracture (HP:0003273)2.11149341
70Skin nodule (HP:0200036)2.10510505
71Abnormality of the ischium (HP:0003174)2.10403152
72Nausea (HP:0002018)2.10401601
73Epidermoid cyst (HP:0200040)2.10204958
74Tetraparesis (HP:0002273)2.09455141
75Knee flexion contracture (HP:0006380)2.09357791
76Hemorrhage of the eye (HP:0011885)2.08517963
77Osteoarthritis (HP:0002758)2.07924989
78Venous abnormality (HP:0002624)2.07696236
79Increased corneal curvature (HP:0100692)2.05967127
80Keratoconus (HP:0000563)2.05967127
81Impaired proprioception (HP:0010831)2.05896444
82Polycythemia (HP:0001901)2.05835485
83Ectopia lentis (HP:0001083)2.05751208
84Infantile muscular hypotonia (HP:0008947)2.05146656
85Duplicated collecting system (HP:0000081)2.03527358
86Rectal prolapse (HP:0002035)2.03508988
87Cervical subluxation (HP:0003308)2.03250626
88Coronal craniosynostosis (HP:0004440)2.02987668
89Preaxial foot polydactyly (HP:0001841)2.02746505
90Muscle fiber splitting (HP:0003555)2.01664579
91Increased CSF protein (HP:0002922)2.01609685
92Vitreoretinal degeneration (HP:0000655)1.99899799
93Wrist flexion contracture (HP:0001239)1.99813156
94Congenital, generalized hypertrichosis (HP:0004540)1.99080070
95Potter facies (HP:0002009)1.98442508
96Facial shape deformation (HP:0011334)1.98442508
97Hypercortisolism (HP:0001578)1.98300326
98Systemic lupus erythematosus (HP:0002725)1.97965656
99Insulin-resistant diabetes mellitus (HP:0000831)1.97559254
100Frequent falls (HP:0002359)1.96875638
101Mildly elevated creatine phosphokinase (HP:0008180)1.95949451
102Bronchomalacia (HP:0002780)1.94977340
103Decreased circulating renin level (HP:0003351)1.92869935
104Pulmonary artery stenosis (HP:0004415)1.92003733
105Abnormality of the renal collecting system (HP:0004742)1.91124531
106Subcapsular cataract (HP:0000523)1.90043859
107Gonadotropin excess (HP:0000837)1.89324867
108Abnormality of the vitreous humor (HP:0004327)1.89261103
109Tarsal synostosis (HP:0008368)1.89240924
110Abnormality of secondary sexual hair (HP:0009888)1.88597892
111Abnormality of the axillary hair (HP:0100134)1.88597892
112Narrow palate (HP:0000189)1.88506785
113Narrow nasal bridge (HP:0000446)1.88472942
114Lipoatrophy (HP:0100578)1.88309796
115Aneurysm (HP:0002617)1.87982577
116Joint laxity (HP:0001388)1.86397737
117Synostosis involving the elbow (HP:0003938)1.86152173
118Humeroradial synostosis (HP:0003041)1.86152173
119Blue sclerae (HP:0000592)1.85511187
120Xanthomatosis (HP:0000991)1.83667442
121Mesangial abnormality (HP:0001966)1.83424261
122Hematochezia (HP:0002573)1.83173978
123Asymmetric septal hypertrophy (HP:0001670)1.82978880
124Generalized amyotrophy (HP:0003700)1.81895777
125Growth hormone excess (HP:0000845)1.80915787
126Polyphagia (HP:0002591)1.80712728
127Mitral regurgitation (HP:0001653)1.80465360
128Aplasia involving bones of the upper limbs (HP:0009823)1.80236355
129Aplasia of the phalanges of the hand (HP:0009802)1.80236355
130Aplasia involving bones of the extremities (HP:0009825)1.80236355
131Aplasia of the musculature (HP:0100854)1.80074921
132Synostosis involving bones of the feet (HP:0009140)1.79036754
133Synostosis involving bones of the lower limbs (HP:0009138)1.79036754
134Polar cataract (HP:0010696)1.78811221
135Wide anterior fontanel (HP:0000260)1.77752367
136Wormian bones (HP:0002645)1.76325310
137Enlarged penis (HP:0000040)1.76024717
138Joint stiffness (HP:0001387)1.75589278
139Limited hip movement (HP:0008800)1.73294644
140Insidious onset (HP:0003587)1.71798247
141Termporal pattern (HP:0011008)1.71798247
142Difficulty running (HP:0009046)1.71268702
143Accelerated skeletal maturation (HP:0005616)1.70785954
144Absent toe (HP:0010760)1.70380378
145Hypoalphalipoproteinemia (HP:0003233)1.70017189
146Gingival overgrowth (HP:0000212)1.69416265
147Hyperlipoproteinemia (HP:0010980)1.69318247
148Ovoid vertebral bodies (HP:0003300)1.68953134
149Hyperpituitarism (HP:0010514)1.68391934
150Thin bony cortex (HP:0002753)1.67556734
151Lumbar hyperlordosis (HP:0002938)1.64728815

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CAMK1G5.79132273
2CAMK1D5.24655970
3DDR23.87210013
4TRIB33.37531910
5SIK13.09241912
6TGFBR22.35259618
7ADRBK22.24784879
8RIPK12.20274134
9PNCK2.13942652
10GRK12.10923341
11DAPK22.02455134
12PDGFRA1.97997768
13LMTK21.96252234
14BCKDK1.90412559
15MYLK1.88754223
16PINK11.86468824
17ADRBK11.85612024
18PRKAA21.82416708
19TIE11.77206219
20FGFR31.75712349
21GRK51.75625935
22INSRR1.54706744
23EPHB21.53703439
24ABL21.49435147
25MST1R1.45161896
26MAPKAPK31.31076130
27MARK21.29498924
28PTK61.28038920
29LATS11.27490806
30PTK2B1.25351094
31STK391.20147712
32PAK21.16873230
33CAMK11.13759925
34TGFBR11.08807058
35PIK3CA1.08697809
36TTN1.08544477
37BMPR1B1.07407617
38OBSCN1.07169022
39NEK91.05463023
40HIPK21.04507052
41MET1.04035497
42PDK21.03534661
43EPHB10.99753133
44PKN10.99669840
45KIT0.96414638
46FGFR20.96269078
47FRK0.95412563
48PRKG10.94046009
49RET0.92439440
50DMPK0.89276767
51MARK10.88934295
52PDGFRB0.87652800
53CDC42BPA0.86194379
54FGFR40.85930483
55FER0.83940534
56CDK60.83751475
57CAMK40.83388595
58PRKD30.82171614
59OXSR10.78405096
60NTRK30.77217779
61TRPM70.76730168
62NLK0.75734509
63PRKCH0.75572817
64NUAK10.74565999
65PHKG10.73104343
66PHKG20.73104343
67ROCK10.71474067
68IGF1R0.70756368
69MKNK20.70752092
70STK38L0.68472340
71PRKD20.68248878
72TNIK0.67778672
73LRRK20.66277499
74FLT30.66101729
75WNK40.65846983
76CAMKK20.65456733
77GSK3A0.64743019
78MAP2K20.64098680
79NTRK20.63367875
80EPHA30.62908528
81MAPK120.62551341
82BMX0.61914544
83ACVR1B0.61452163
84PDK40.61339471
85PDK30.61339471
86JAK10.59927557
87MAPK150.59899970
88MAPK130.59861921
89ERBB40.59756347
90TEC0.59396954
91LATS20.59107649
92EEF2K0.59102983
93MAP3K70.57912609
94IRAK10.57639659
95MAPKAPK50.56321669
96AKT30.56087403
97PRKD10.55118708
98CSF1R0.54922408
99PRKG20.54817157
100PRKACA0.54377287
101PKN20.53230617
102MOS0.51764467
103MAP2K10.51633894
104SGK30.50383645
105PRKCE0.49816286
106ILK0.48988651
107TYRO30.48584448
108PAK30.48389439
109TNK20.47937647
110MAPK70.47152501
111MUSK0.46861184
112CDK90.45778776
113ERN10.45094813
114INSR0.44940889
115IRAK20.44774930
116SRC0.44654065
117PRKAA10.44644449
118RPS6KA20.44375951
119JAK20.44316610
120NTRK10.43983479
121MAPK40.43792389
122SGK4940.43562757
123SGK2230.43562757
124ITK0.42698574
125PTK20.42446399
126JAK30.42368876
127MAPK30.42352431
128STK110.42294105
129STK380.42124837
130PRKCG0.40437987
131ABL10.40362123
132CDK30.40060325
133MAP3K60.39994915
134MTOR0.39955901
135PRKACB0.39870642
136TYK20.39662778
137FGFR10.38617253
138SGK20.38036499
139PDK10.37368085
140PRKACG0.36318829
141KDR0.36012666
142PDPK10.35171848

Predicted pathways (KEGG)

RankGene SetZ-score
1Nitrogen metabolism_Homo sapiens_hsa009104.23011732
2ECM-receptor interaction_Homo sapiens_hsa045123.28542855
3Regulation of lipolysis in adipocytes_Homo sapiens_hsa049232.95547955
4Fatty acid biosynthesis_Homo sapiens_hsa000612.93574528
5Protein digestion and absorption_Homo sapiens_hsa049742.90148539
6Histidine metabolism_Homo sapiens_hsa003402.82460258
7PPAR signaling pathway_Homo sapiens_hsa033202.81764255
8Propanoate metabolism_Homo sapiens_hsa006402.34650325
9Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049642.00543831
10Fatty acid metabolism_Homo sapiens_hsa012121.94812240
11Focal adhesion_Homo sapiens_hsa045101.81694460
12Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.80073305
13Tyrosine metabolism_Homo sapiens_hsa003501.74803149
14Fatty acid degradation_Homo sapiens_hsa000711.65936943
15AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.57329770
16Glycerolipid metabolism_Homo sapiens_hsa005611.53898884
17Amoebiasis_Homo sapiens_hsa051461.53253860
18alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.48965056
19Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.37722553
20Basal cell carcinoma_Homo sapiens_hsa052171.37161817
21Adipocytokine signaling pathway_Homo sapiens_hsa049201.36582505
22Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.26461621
23Hedgehog signaling pathway_Homo sapiens_hsa043401.22861068
24Linoleic acid metabolism_Homo sapiens_hsa005911.17818141
25Small cell lung cancer_Homo sapiens_hsa052221.15997324
26AMPK signaling pathway_Homo sapiens_hsa041521.14049927
27Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.12328505
28Sulfur relay system_Homo sapiens_hsa041221.11361665
29beta-Alanine metabolism_Homo sapiens_hsa004101.10155399
30Malaria_Homo sapiens_hsa051441.09469631
31TGF-beta signaling pathway_Homo sapiens_hsa043501.09162777
32Ovarian steroidogenesis_Homo sapiens_hsa049131.09004698
33Proteoglycans in cancer_Homo sapiens_hsa052051.08878506
34Morphine addiction_Homo sapiens_hsa050321.08569412
35Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.07341279
36Cyanoamino acid metabolism_Homo sapiens_hsa004601.03472135
37Insulin resistance_Homo sapiens_hsa049311.03418628
38Adherens junction_Homo sapiens_hsa045201.01958287
39Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.01232941
40Retinol metabolism_Homo sapiens_hsa008300.97461297
41Dilated cardiomyopathy_Homo sapiens_hsa054140.97310128
42PI3K-Akt signaling pathway_Homo sapiens_hsa041510.92281547
43Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.92074190
44Complement and coagulation cascades_Homo sapiens_hsa046100.91338294
45African trypanosomiasis_Homo sapiens_hsa051430.89163530
46Butanoate metabolism_Homo sapiens_hsa006500.88634835
47Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.87983219
48Maturity onset diabetes of the young_Homo sapiens_hsa049500.87055374
49Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.85577432
50Viral myocarditis_Homo sapiens_hsa054160.85253272
51Renin secretion_Homo sapiens_hsa049240.84236209
52Melanogenesis_Homo sapiens_hsa049160.83320502
53Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.83182374
54Staphylococcus aureus infection_Homo sapiens_hsa051500.82742590
55Dorso-ventral axis formation_Homo sapiens_hsa043200.82233188
56Hippo signaling pathway_Homo sapiens_hsa043900.82190530
57Bile secretion_Homo sapiens_hsa049760.82028329
58cAMP signaling pathway_Homo sapiens_hsa040240.81838680
59Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.80165326
60Platelet activation_Homo sapiens_hsa046110.79069074
61Ether lipid metabolism_Homo sapiens_hsa005650.78196482
62Thyroid hormone synthesis_Homo sapiens_hsa049180.77935913
63Starch and sucrose metabolism_Homo sapiens_hsa005000.77555496
64Arachidonic acid metabolism_Homo sapiens_hsa005900.76862324
65Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.76647314
66Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.76194485
67Circadian entrainment_Homo sapiens_hsa047130.75869311
68Leukocyte transendothelial migration_Homo sapiens_hsa046700.75204247
69Cocaine addiction_Homo sapiens_hsa050300.74901854
70Caffeine metabolism_Homo sapiens_hsa002320.72964178
71Glycosaminoglycan degradation_Homo sapiens_hsa005310.72707820
72Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.72322903
73Fat digestion and absorption_Homo sapiens_hsa049750.72160150
74Lysine degradation_Homo sapiens_hsa003100.72080281
75Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.71192989
76Salivary secretion_Homo sapiens_hsa049700.71174225
77Tryptophan metabolism_Homo sapiens_hsa003800.70634856
78Pathways in cancer_Homo sapiens_hsa052000.70224506
79Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.69787862
80Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.69260398
81Insulin signaling pathway_Homo sapiens_hsa049100.66893234
82Glycerophospholipid metabolism_Homo sapiens_hsa005640.65423942
83Insulin secretion_Homo sapiens_hsa049110.64610181
84Longevity regulating pathway - mammal_Homo sapiens_hsa042110.63906817
85ABC transporters_Homo sapiens_hsa020100.63822265
86Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.63108702
87Vascular smooth muscle contraction_Homo sapiens_hsa042700.62208705
88cGMP-PKG signaling pathway_Homo sapiens_hsa040220.62194158
89Carbohydrate digestion and absorption_Homo sapiens_hsa049730.61599315
90Axon guidance_Homo sapiens_hsa043600.59953859
91Glucagon signaling pathway_Homo sapiens_hsa049220.59891425
92Wnt signaling pathway_Homo sapiens_hsa043100.58871863
93Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.58863411
94Vitamin digestion and absorption_Homo sapiens_hsa049770.58701867
95Tight junction_Homo sapiens_hsa045300.58084691
96Gastric acid secretion_Homo sapiens_hsa049710.58080511
97Primary bile acid biosynthesis_Homo sapiens_hsa001200.57016024
98Pyruvate metabolism_Homo sapiens_hsa006200.57008881
99Taste transduction_Homo sapiens_hsa047420.56600578
100Notch signaling pathway_Homo sapiens_hsa043300.56253019
101Peroxisome_Homo sapiens_hsa041460.54285016
102Arginine biosynthesis_Homo sapiens_hsa002200.53113760
103Toxoplasmosis_Homo sapiens_hsa051450.52839454
104Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.51400030
105Oxytocin signaling pathway_Homo sapiens_hsa049210.51358201
106Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.50539552
107Fatty acid elongation_Homo sapiens_hsa000620.50531729
108Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.49853961
109Renin-angiotensin system_Homo sapiens_hsa046140.49617583
110Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.49398539
111Central carbon metabolism in cancer_Homo sapiens_hsa052300.48578662
112Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.47191780
113Phospholipase D signaling pathway_Homo sapiens_hsa040720.46971272
114Estrogen signaling pathway_Homo sapiens_hsa049150.46258715
115Phototransduction_Homo sapiens_hsa047440.45509280
116Glutamatergic synapse_Homo sapiens_hsa047240.45497466
117Olfactory transduction_Homo sapiens_hsa047400.45219368
118Choline metabolism in cancer_Homo sapiens_hsa052310.44762676
119Aldosterone synthesis and secretion_Homo sapiens_hsa049250.43770701
120Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.43355814
121Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.42592751
122Steroid hormone biosynthesis_Homo sapiens_hsa001400.42279364
123Phenylalanine metabolism_Homo sapiens_hsa003600.41728988
124Type II diabetes mellitus_Homo sapiens_hsa049300.40265816
125Thyroid hormone signaling pathway_Homo sapiens_hsa049190.39095080
126Arginine and proline metabolism_Homo sapiens_hsa003300.38903801
127Ras signaling pathway_Homo sapiens_hsa040140.38690364
128Mineral absorption_Homo sapiens_hsa049780.38499720
129Serotonergic synapse_Homo sapiens_hsa047260.38465792
130Rap1 signaling pathway_Homo sapiens_hsa040150.38404557
131Cardiac muscle contraction_Homo sapiens_hsa042600.37164490
132Prostate cancer_Homo sapiens_hsa052150.37122420
133Calcium signaling pathway_Homo sapiens_hsa040200.36786845
134Long-term depression_Homo sapiens_hsa047300.36523329
135Gap junction_Homo sapiens_hsa045400.36295653
136Acute myeloid leukemia_Homo sapiens_hsa052210.36263204
137Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.35350839
138Chemical carcinogenesis_Homo sapiens_hsa052040.35099620
139GABAergic synapse_Homo sapiens_hsa047270.34404343
140Melanoma_Homo sapiens_hsa052180.33049897
141Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.32926568

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »