ITK

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes an intracellular tyrosine kinase expressed in T-cells. The protein contains both SH2 and SH3 domains which are often found in intracellular kinases. It is thought to play a role in T-cell proliferation and differentiation. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative T cell selection (GO:0043383)8.25621477
2negative thymic T cell selection (GO:0045060)7.73389320
3positive regulation of gamma-delta T cell activation (GO:0046645)7.55364431
4positive T cell selection (GO:0043368)7.09594576
5positive thymic T cell selection (GO:0045059)7.01809701
6regulation of isotype switching to IgG isotypes (GO:0048302)7.01093794
7regulation of gamma-delta T cell differentiation (GO:0045586)6.93389015
8negative regulation of cell killing (GO:0031342)6.87973743
9negative regulation of leukocyte mediated cytotoxicity (GO:0001911)6.87973743
10positive regulation of interleukin-2 biosynthetic process (GO:0045086)6.72777039
11thymic T cell selection (GO:0045061)6.62415022
12T cell selection (GO:0045058)6.49726925
13response to interleukin-15 (GO:0070672)6.47394453
14positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)6.28492538
15regulation of gamma-delta T cell activation (GO:0046643)6.25453143
16cellular response to interleukin-15 (GO:0071350)6.08212098
17antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)6.01267015
18antigen processing and presentation of endogenous peptide antigen (GO:0002483)6.01267015
19antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.88896348
20tolerance induction (GO:0002507)5.48885170
21activated T cell proliferation (GO:0050798)5.27947614
22* T cell receptor signaling pathway (GO:0050852)5.24453846
23regulation of T cell tolerance induction (GO:0002664)5.23231890
24regulation of interleukin-12 biosynthetic process (GO:0045075)5.06820329
25T cell costimulation (GO:0031295)5.00625946
26antigen processing and presentation of endogenous antigen (GO:0019883)4.96915909
27lymphocyte costimulation (GO:0031294)4.94776462
28regulation of interleukin-2 biosynthetic process (GO:0045076)4.90596727
29T cell migration (GO:0072678)4.87765057
30positive regulation of isotype switching (GO:0045830)4.84824489
31leukocyte aggregation (GO:0070486)4.80513634
32regulation of regulatory T cell differentiation (GO:0045589)4.76857538
33regulation of alpha-beta T cell proliferation (GO:0046640)4.75374320
34* interferon-gamma production (GO:0032609)4.72604441
35regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)4.68492898
36positive regulation of granulocyte differentiation (GO:0030854)4.64438356
37positive regulation of interleukin-2 production (GO:0032743)4.56444836
38negative regulation of T cell mediated immunity (GO:0002710)4.52799322
39positive regulation of immunoglobulin mediated immune response (GO:0002891)4.44565338
40positive regulation of B cell mediated immunity (GO:0002714)4.44565338
41positive regulation of alpha-beta T cell proliferation (GO:0046641)4.44239849
42regulation of isotype switching (GO:0045191)4.38311826
43positive regulation of tolerance induction (GO:0002645)4.29995357
44regulation of T cell receptor signaling pathway (GO:0050856)4.24552909
45* antigen receptor-mediated signaling pathway (GO:0050851)4.23985870
46regulation of B cell receptor signaling pathway (GO:0050855)4.18595948
47positive regulation of DNA recombination (GO:0045911)4.18154877
48positive regulation of humoral immune response (GO:0002922)4.14940898
49regulation of antigen receptor-mediated signaling pathway (GO:0050854)4.11361731
50regulation of immunoglobulin mediated immune response (GO:0002889)4.06390663
51positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)3.99963038
52positive regulation of natural killer cell mediated immunity (GO:0002717)3.99963038
53regulation of chronic inflammatory response (GO:0002676)3.98717447
54regulation of natural killer cell mediated cytotoxicity (GO:0042269)3.93452971
55regulation of natural killer cell mediated immunity (GO:0002715)3.93452971
56regulation of B cell mediated immunity (GO:0002712)3.91571432
57regulation of immunoglobulin production (GO:0002637)3.79144001
58positive regulation of immunoglobulin production (GO:0002639)3.77568601
59regulation of B cell differentiation (GO:0045577)3.77566452
60regulation of tolerance induction (GO:0002643)3.73246795
61regulation of interleukin-2 production (GO:0032663)3.72850306
62* T cell differentiation (GO:0030217)3.70347173
63NIK/NF-kappaB signaling (GO:0038061)3.65765389
64regulation of response to interferon-gamma (GO:0060330)3.61431020
65positive regulation of T cell differentiation in thymus (GO:0033089)3.61002478
66positive regulation of leukocyte mediated cytotoxicity (GO:0001912)3.60917107
67regulation of interferon-gamma-mediated signaling pathway (GO:0060334)3.60347628
68mast cell activation (GO:0045576)3.54777835
69negative regulation of lymphocyte mediated immunity (GO:0002707)3.52516912
70negative regulation of leukocyte mediated immunity (GO:0002704)3.51638523
71* alpha-beta T cell activation (GO:0046631)3.50348284
72* alpha-beta T cell differentiation (GO:0046632)3.50291878
73Peyers patch development (GO:0048541)3.49401404
74mucosal-associated lymphoid tissue development (GO:0048537)3.49401404
75positive regulation of T cell mediated cytotoxicity (GO:0001916)3.49182329
76regulation of leukocyte mediated cytotoxicity (GO:0001910)3.48640467
77positive regulation of inflammatory response to antigenic stimulus (GO:0002863)3.48627421
78CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)3.47834038
79tyrosine phosphorylation of STAT protein (GO:0007260)3.46361937
80B cell receptor signaling pathway (GO:0050853)3.42966517
81positive regulation of cell killing (GO:0031343)3.41437675
82JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)3.33753253
83positive regulation of B cell differentiation (GO:0045579)3.31558555
84regulation of cell killing (GO:0031341)3.31518277
85antigen processing and presentation via MHC class Ib (GO:0002475)3.29833512
86* T cell activation (GO:0042110)3.28306647
87positive regulation of T cell cytokine production (GO:0002726)3.26612763
88CD4-positive, alpha-beta T cell differentiation (GO:0043367)3.25348619
89CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)3.24899796
90T-helper cell differentiation (GO:0042093)3.24899796
91positive regulation of lymphocyte mediated immunity (GO:0002708)3.24806541
92T cell homeostasis (GO:0043029)3.24789117
93response to type I interferon (GO:0034340)3.21527092
94type I interferon signaling pathway (GO:0060337)3.21357854
95cellular response to type I interferon (GO:0071357)3.21357854
96T cell proliferation (GO:0042098)3.19131377
97alpha-beta T cell activation involved in immune response (GO:0002287)3.18535076
98T cell differentiation involved in immune response (GO:0002292)3.18535076
99alpha-beta T cell differentiation involved in immune response (GO:0002293)3.18535076
100negative regulation of adaptive immune response (GO:0002820)3.16673507
101leukocyte cell-cell adhesion (GO:0007159)3.15537025
102positive regulation of T cell activation (GO:0050870)3.15089500
103negative regulation of T cell receptor signaling pathway (GO:0050860)3.14943086
104regulation of defense response to virus by virus (GO:0050690)3.14616590
105regulation of lymphocyte mediated immunity (GO:0002706)3.11335003
106natural killer cell activation (GO:0030101)3.11233032
107lymphocyte migration (GO:0072676)3.10479213
108regulation of granulocyte differentiation (GO:0030852)3.07032125
109negative regulation of adaptive immune response based on somatic recombination of immune receptors b3.06455126
110positive regulation of alpha-beta T cell activation (GO:0046635)3.05861716
111myeloid dendritic cell activation (GO:0001773)3.04173186
112negative regulation of interleukin-12 production (GO:0032695)3.04154296
113negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.01370287
114regulation of alpha-beta T cell activation (GO:0046634)3.01306375
115lymph node development (GO:0048535)3.00129650
116negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)2.99841908
117positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.99319826
118hepatocyte apoptotic process (GO:0097284)2.98220175
119positive regulation of T cell differentiation (GO:0045582)2.96748696
120natural killer cell differentiation (GO:0001779)2.96663584
121cellular response to interleukin-4 (GO:0071353)2.96487506
122regulation of type I interferon-mediated signaling pathway (GO:0060338)2.96467817
123regulation of T cell mediated cytotoxicity (GO:0001914)2.93831642
124negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.92841933
125negative regulation of T-helper cell differentiation (GO:0045623)2.92841933
126cellular extravasation (GO:0045123)2.91531883

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP3_17237761_ChIP-ChIP_TREG_Mouse9.32683997
2* STAT6_20620947_ChIP-Seq_CD4_POS_T_Human6.82693677
3STAT3_20064451_ChIP-Seq_CD4+T_Mouse4.28469705
4RUNX_20019798_ChIP-Seq_JUKART_Human4.05396845
5FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse3.94539211
6MYC_22102868_ChIP-Seq_BL_Human3.92970747
7STAT4_19710469_ChIP-ChIP_TH1__Mouse3.63284266
8IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.55051516
9MYB_26560356_Chip-Seq_TH2_Human3.47391480
10IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.23885294
11IRF8_22096565_ChIP-ChIP_GC-B_Human3.18046034
12E2F7_22180533_ChIP-Seq_HELA_Human3.14495209
13MAF_26560356_Chip-Seq_TH1_Human3.05833425
14NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.03733333
15MYB_26560356_Chip-Seq_TH1_Human2.88639040
16MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.79273245
17NOTCH1_21737748_ChIP-Seq_TLL_Human2.77848330
18UTX_26944678_Chip-Seq_JUKART_Human2.75798645
19EGR1_19374776_ChIP-ChIP_THP-1_Human2.72023560
20SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.33447982
21BP1_19119308_ChIP-ChIP_Hs578T_Human2.32863560
22KDM2B_26808549_Chip-Seq_HPB-ALL_Human2.31764915
23MAF_26560356_Chip-Seq_TH2_Human2.19670279
24VDR_21846776_ChIP-Seq_THP-1_Human2.18330310
25GATA3_27048872_Chip-Seq_THYMUS_Human2.17172823
26TCF7_22412390_ChIP-Seq_EML_Mouse2.14145651
27RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.01423274
28KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.90328826
29SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.83659648
30* RUNX1_22412390_ChIP-Seq_EML_Mouse1.83535273
31KDM2B_26808549_Chip-Seq_DND41_Human1.83380198
32SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.81831716
33NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.80196585
34E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.77799289
35MYB_21317192_ChIP-Seq_ERMYB_Mouse1.73996498
36ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.73050960
37RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.62460700
38VDR_24763502_ChIP-Seq_THP-1_Human1.60553344
39IRF8_21731497_ChIP-ChIP_J774_Mouse1.59677871
40SPI1_23547873_ChIP-Seq_NB4_Human1.57377469
41RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.56208620
42VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.55976585
43SCL_19346495_ChIP-Seq_HPC-7_Human1.55799924
44* IRF8_27001747_Chip-Seq_BMDM_Mouse1.54723766
45KDM2B_26808549_Chip-Seq_SUP-B15_Human1.52914648
46SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.51531309
47BRD4_27068464_Chip-Seq_AML-cells_Mouse1.44698358
48CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.42430728
49FLI1_27457419_Chip-Seq_LIVER_Mouse1.40296355
50KDM2B_26808549_Chip-Seq_JURKAT_Human1.36216358
51MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.31459260
52TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.31186015
53CIITA_25753668_ChIP-Seq_RAJI_Human1.28459261
54FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.25295423
55GATA3_26560356_Chip-Seq_TH2_Human1.24207782
56ELF1_17652178_ChIP-ChIP_JURKAT_Human1.24029721
57SMAD_19615063_ChIP-ChIP_OVARY_Human1.24000453
58PU_27001747_Chip-Seq_BMDM_Mouse1.19451813
59PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.17001155
60SPI1_23127762_ChIP-Seq_K562_Human1.16378669
61FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.16076712
62VDR_23849224_ChIP-Seq_CD4+_Human1.13832965
63BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.12706022
64SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.08937615
65* GATA2_22383799_ChIP-Seq_G1ME_Mouse1.07728396
66TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.06637546
67ELK3_25401928_ChIP-Seq_HUVEC_Human1.06027954
68GATA3_26560356_Chip-Seq_TH1_Human1.04727554
69PCGF2_27294783_Chip-Seq_ESCs_Mouse1.04423159
70PCGF2_27294783_Chip-Seq_NPCs_Mouse1.01894535
71SMRT_27268052_Chip-Seq_Bcells_Human1.00667607
72GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.98794439
73GATA1_22025678_ChIP-Seq_K562_Human0.97767954
74FOXP3_21729870_ChIP-Seq_TREG_Human0.97624694
75FOXM1_23109430_ChIP-Seq_U2OS_Human0.97511598
76EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse0.93413198
77CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.93150937
78PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.92674395
79GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.92083961
80DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.90910779
81* TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.90046230
82Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.88308228
83GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.88138563
84STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.87238836
85CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.84425699
86NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.83930580
87NCOR1_26117541_ChIP-Seq_K562_Human0.83494208
88CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.83436351
89* RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.83341385
90PU.1_20513432_ChIP-Seq_Bcells_Mouse0.82721906
91ELK1_19687146_ChIP-ChIP_HELA_Human0.82552967
92VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.82019457
93E2F4_17652178_ChIP-ChIP_JURKAT_Human0.81276532
94* PRDM14_20953172_ChIP-Seq_ESCs_Human0.80990960
95LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.79682803
96NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.78638319
97* CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.74721223
98ERG_20887958_ChIP-Seq_HPC-7_Mouse0.74353995
99TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.74031357
100NFE2_27457419_Chip-Seq_LIVER_Mouse0.73797872
101GATA2_21666600_ChIP-Seq_HMVEC_Human0.73129511
102STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.72717291
103SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.72120612
104SOX11_23321250_ChIP-ChIP_Z138-A519-JVM2_Human0.72088769
105CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.71478568
106GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.71298770
107* TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human0.71268102
108GATA1_22383799_ChIP-Seq_G1ME_Mouse0.71059152
109SUZ12_27294783_Chip-Seq_NPCs_Mouse0.71028606
110* FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.70867356
111EZH2_27294783_Chip-Seq_NPCs_Mouse0.70682949
112HOXB4_20404135_ChIP-ChIP_EML_Mouse0.69655458
113OCT4_21477851_ChIP-Seq_ESCs_Mouse0.66816034
114PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.66361592
115FOXO3_23340844_ChIP-Seq_DLD1_Human0.66361249
116GATA1_19941827_ChIP-Seq_MEL_Mouse0.65765492
117GATA1_19941826_ChIP-Seq_K562_Human0.65117783
118VDR_24787735_ChIP-Seq_THP-1_Human0.64490003
119E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.64087538
120CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.62721351
121RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.61608194
122SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.61186243
123PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.61012849
124HIF1A_21447827_ChIP-Seq_MCF-7_Human0.60866791
125KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.60398728
126GATA2_19941826_ChIP-Seq_K562_Human0.59661775
127LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.58979753
128ETS1_22383799_ChIP-Seq_G1ME_Mouse0.58590622

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003763_abnormal_thymus_physiology6.19638492
2MP0005671_abnormal_response_to4.58351061
3MP0000685_abnormal_immune_system3.83821621
4* MP0001800_abnormal_humoral_immune3.10783925
5MP0009333_abnormal_splenocyte_physiolog3.02642911
6MP0001835_abnormal_antigen_presentation3.01649120
7MP0005387_immune_system_phenotype3.01553315
8MP0001790_abnormal_immune_system3.01553315
9MP0002166_altered_tumor_susceptibility2.99009389
10MP0005000_abnormal_immune_tolerance2.96360273
11MP0003300_gastrointestinal_ulcer2.91720576
12* MP0000703_abnormal_thymus_morphology2.79897736
13* MP0002398_abnormal_bone_marrow2.78842667
14MP0003436_decreased_susceptibility_to2.73463222
15* MP0002723_abnormal_immune_serum2.73229493
16MP0002405_respiratory_system_inflammati2.72907338
17* MP0002420_abnormal_adaptive_immunity2.70025295
18MP0001873_stomach_inflammation2.69664570
19* MP0001819_abnormal_immune_cell2.66247221
20MP0002006_tumorigenesis2.57009138
21MP0009785_altered_susceptibility_to2.54157701
22MP0006082_CNS_inflammation2.43847202
23* MP0002452_abnormal_antigen_presenting2.42434403
24MP0003866_abnormal_defecation2.40716344
25* MP0000716_abnormal_immune_system2.39002460
26MP0003303_peritoneal_inflammation2.33359294
27MP0002722_abnormal_immune_system2.31644910
28MP0010155_abnormal_intestine_physiology2.31308161
29MP0004947_skin_inflammation2.26742325
30MP0000689_abnormal_spleen_morphology2.19328432
31MP0002396_abnormal_hematopoietic_system2.18892860
32* MP0005025_abnormal_response_to2.16757454
33MP0003724_increased_susceptibility_to2.11208633
34MP0002933_joint_inflammation2.09009613
35MP0004510_myositis2.05903089
36* MP0002429_abnormal_blood_cell1.92030789
37MP0002148_abnormal_hypersensitivity_rea1.82275468
38MP0001853_heart_inflammation1.78653559
39MP0001845_abnormal_inflammatory_respons1.66877193
40MP0002419_abnormal_innate_immunity1.60290234
41MP0004808_abnormal_hematopoietic_stem1.59956411
42MP0004381_abnormal_hair_follicle1.45578271
43MP0005310_abnormal_salivary_gland1.43688542
44MP0005464_abnormal_platelet_physiology1.39027429
45MP0000858_altered_metastatic_potential1.38833569
46MP0000465_gastrointestinal_hemorrhage1.35343339
47MP0002009_preneoplasia1.29746413
48MP0000569_abnormal_digit_pigmentation1.27565628
49MP0000490_abnormal_crypts_of1.22977217
50MP0002132_abnormal_respiratory_system1.22626318
51MP0001533_abnormal_skeleton_physiology1.22302209
52MP0003448_altered_tumor_morphology1.20000377
53MP0008961_abnormal_basal_metabolism1.19607928
54MP0002138_abnormal_hepatobiliary_system1.14156764
55MP0001851_eye_inflammation1.07425403
56MP0005397_hematopoietic_system_phenotyp1.03235076
57MP0001545_abnormal_hematopoietic_system1.03235076
58MP0002019_abnormal_tumor_incidence1.00659526
59MP0004130_abnormal_muscle_cell1.00503858
60MP0002998_abnormal_bone_remodeling1.00381886
61MP0008057_abnormal_DNA_replication1.00110153
62MP0008469_abnormal_protein_level0.97933834
63MP0002163_abnormal_gland_morphology0.94665953
64MP0010352_gastrointestinal_tract_polyps0.93566091
65MP0003172_abnormal_lysosome_physiology0.91648610
66MP0005075_abnormal_melanosome_morpholog0.89350179
67MP0005076_abnormal_cell_differentiation0.87242789
68MP0004883_abnormal_blood_vessel0.82213358
69MP0001986_abnormal_taste_sensitivity0.80561864
70MP0001919_abnormal_reproductive_system0.79619080
71MP0008877_abnormal_DNA_methylation0.76482761
72MP0005023_abnormal_wound_healing0.75414539
73MP0001348_abnormal_lacrimal_gland0.74010713
74MP0009278_abnormal_bone_marrow0.73898236
75MP0003828_pulmonary_edema0.73550436
76MP0000015_abnormal_ear_pigmentation0.71053065
77MP0001881_abnormal_mammary_gland0.68175510
78MP0003077_abnormal_cell_cycle0.67590648
79MP0008260_abnormal_autophagy0.65016107
80MP0001243_abnormal_dermal_layer0.64849893
81MP0001663_abnormal_digestive_system0.64243137
82MP0009765_abnormal_xenobiotic_induced0.64068919
83MP0003795_abnormal_bone_structure0.64047428
84MP0000609_abnormal_liver_physiology0.63861102
85MP0008007_abnormal_cellular_replicative0.63769157
86MP0001501_abnormal_sleep_pattern0.61672080
87MP0009763_increased_sensitivity_to0.61245317
88MP0000604_amyloidosis0.57991385
89MP0000477_abnormal_intestine_morphology0.57895604
90MP0002822_catalepsy0.56891633
91MP0003453_abnormal_keratinocyte_physiol0.55444402
92MP0001216_abnormal_epidermal_layer0.55410857
93MP0003646_muscle_fatigue0.54870204
94MP0000372_irregular_coat_pigmentation0.54453696
95MP0004142_abnormal_muscle_tone0.53507126
96MP0005379_endocrine/exocrine_gland_phen0.52371078
97MP0003045_fibrosis0.52074601
98MP0002254_reproductive_system_inflammat0.51688507
99MP0002928_abnormal_bile_duct0.51410854
100MP0009764_decreased_sensitivity_to0.50340701
101MP0001765_abnormal_ion_homeostasis0.50188173
102MP0001191_abnormal_skin_condition0.50016346
103MP0005451_abnormal_body_composition0.49959995
104MP0010094_abnormal_chromosome_stability0.49505557
105MP0000627_abnormal_mammary_gland0.48634830
106MP0002136_abnormal_kidney_physiology0.48202851
107MP0003091_abnormal_cell_migration0.47898167
108MP0005390_skeleton_phenotype0.46817897
109MP0003252_abnormal_bile_duct0.46504285
110MP0003183_abnormal_peptide_metabolism0.45185628
111MP0000371_diluted_coat_color0.45156078
112MP0004957_abnormal_blastocyst_morpholog0.44119828
113MP0003693_abnormal_embryo_hatching0.43763243
114MP0000367_abnormal_coat/_hair0.42618355
115MP0002693_abnormal_pancreas_physiology0.42598696
116MP0009115_abnormal_fat_cell0.42550711
117MP0000249_abnormal_blood_vessel0.42509733
118MP0005174_abnormal_tail_pigmentation0.42206120
119MP0003221_abnormal_cardiomyocyte_apopto0.41912762
120MP0000350_abnormal_cell_proliferation0.41390094
121MP0002277_abnormal_respiratory_mucosa0.41137042
122MP0003787_abnormal_imprinting0.41029719
123MP0005381_digestive/alimentary_phenotyp0.40286075
124MP0000313_abnormal_cell_death0.37414008
125MP0004185_abnormal_adipocyte_glucose0.35869527
126MP0008873_increased_physiological_sensi0.35265309
127MP0008569_lethality_at_weaning0.35241024

Predicted human phenotypes

RankGene SetZ-score
1T lymphocytopenia (HP:0005403)8.60402390
2Abnormality of T cell number (HP:0011839)8.27353610
3Severe combined immunodeficiency (HP:0004430)6.04477879
4Abnormality of T cells (HP:0002843)5.79830833
5Combined immunodeficiency (HP:0005387)5.58939873
6Panhypogammaglobulinemia (HP:0003139)4.84493996
7Recurrent bronchitis (HP:0002837)4.69204577
8Nasal polyposis (HP:0100582)4.63261678
9Recurrent fungal infections (HP:0002841)4.63174995
10Myositis (HP:0100614)4.61990519
11Recurrent viral infections (HP:0004429)4.56365632
12B lymphocytopenia (HP:0010976)4.48385560
13Abnormality of B cell number (HP:0010975)4.48385560
14IgM deficiency (HP:0002850)4.34393493
15Optic neuritis (HP:0100653)4.29769043
16Retrobulbar optic neuritis (HP:0100654)4.29769043
17Chronic otitis media (HP:0000389)4.11382123
18Abnormality of eosinophils (HP:0001879)4.04957737
19Eosinophilia (HP:0001880)3.91475179
20Chronic diarrhea (HP:0002028)3.87007578
21Abnormality of the nasal mucosa (HP:0000433)3.80577075
22Thyroiditis (HP:0100646)3.76624672
23Abnormality of the fingertips (HP:0001211)3.71344390
24Abnormal delayed hypersensitivity skin test (HP:0002963)3.70471265
25Orchitis (HP:0100796)3.70255500
26Recurrent bacterial skin infections (HP:0005406)3.69690403
27Autoimmune hemolytic anemia (HP:0001890)3.64398376
28Gastrointestinal infarctions (HP:0005244)3.62329072
29Chronic mucocutaneous candidiasis (HP:0002728)3.59326042
30Recurrent cutaneous fungal infections (HP:0011370)3.59326042
31Joint swelling (HP:0001386)3.55708947
32Eczematoid dermatitis (HP:0000976)3.55488613
33* IgG deficiency (HP:0004315)3.54944788
34Leukocytosis (HP:0001974)3.52038996
35Increased IgM level (HP:0003496)3.49948841
36Recurrent abscess formation (HP:0002722)3.44749026
37Abnormality of T cell physiology (HP:0011840)3.44641482
38Increased density of long bones (HP:0006392)3.42670854
39Pustule (HP:0200039)3.41933585
40Granulocytopenia (HP:0001913)3.34398042
41Hemoptysis (HP:0002105)3.33711978
42Pulmonary infiltrates (HP:0002113)3.23502228
43Arterial thrombosis (HP:0004420)3.18274674
44IgA deficiency (HP:0002720)3.17928947
45Lymphopenia (HP:0001888)3.17500818
46Vasculitis (HP:0002633)3.15416988
47Hypoplasia of the thymus (HP:0000778)3.10109781
48Abnormality of cells of the lymphoid lineage (HP:0012140)3.09377527
49* Stomatitis (HP:0010280)3.07388820
50Keratoconjunctivitis sicca (HP:0001097)3.02194505
51Stomach cancer (HP:0012126)3.00961474
52Meningitis (HP:0001287)2.96305075
53Abnormality of macrophages (HP:0004311)2.90261825
54Persistence of primary teeth (HP:0006335)2.90097186
55Encephalitis (HP:0002383)2.85897451
56Papilledema (HP:0001085)2.75104288
57Autoimmune thrombocytopenia (HP:0001973)2.74927706
58Chest pain (HP:0100749)2.73441527
59Keratoconjunctivitis (HP:0001096)2.72165255
60Mediastinal lymphadenopathy (HP:0100721)2.71531345
61Spontaneous hematomas (HP:0007420)2.70498536
62Pulmonary embolism (HP:0002204)2.66010681
63Bronchitis (HP:0012387)2.64796626
64Thrombocytosis (HP:0001894)2.63963984
65Basal cell carcinoma (HP:0002671)2.62091532
66Increased IgE level (HP:0003212)2.57274878
67Recurrent sinusitis (HP:0011108)2.54874812
68Abnormality of the prostate (HP:0008775)2.53495989
69Ureteral stenosis (HP:0000071)2.53117914
70Inflammation of the large intestine (HP:0002037)2.44945031
71Obstructive lung disease (HP:0006536)2.44054588
72Chronic obstructive pulmonary disease (HP:0006510)2.44054588
73Gangrene (HP:0100758)2.40171103
74Gastrointestinal inflammation (HP:0004386)2.39617087
75Hypochromic anemia (HP:0001931)2.38271791
76Hypergammaglobulinemia (HP:0010702)2.36800690
77* Lymphoma (HP:0002665)2.36336457
78Ureteral obstruction (HP:0006000)2.30917925
79Alveolar cell carcinoma (HP:0006519)2.29119015
80Amaurosis fugax (HP:0100576)2.28951196
81Neoplasm of the tracheobronchial system (HP:0100552)2.23277646
82Hypoproteinemia (HP:0003075)2.21553362
83Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.21410938
84Gingivitis (HP:0000230)2.20772333
85Acute hepatic failure (HP:0006554)2.19096768
86Verrucae (HP:0200043)2.16238130
87Papilloma (HP:0012740)2.16238130
88Epistaxis (HP:0000421)2.15867778
89Recurrent gram-negative bacterial infections (HP:0005420)2.15389888
90Chronic sinusitis (HP:0011109)2.13549844
91Slow saccadic eye movements (HP:0000514)2.10185173
92Bronchiectasis (HP:0002110)2.06216412
93Abnormal platelet volume (HP:0011876)2.02858704
94Anorexia (HP:0002039)2.01797287
95Hypochromic microcytic anemia (HP:0004840)2.01128976
96Cheilitis (HP:0100825)2.00233011
97Hemiplegia (HP:0002301)1.98556099
98Gingival bleeding (HP:0000225)1.95509573
99Microcytic anemia (HP:0001935)1.95194319
100Glomerulopathy (HP:0100820)1.93880515
101Aplasia/Hypoplasia of the thymus (HP:0010515)1.91789041
102Recurrent skin infections (HP:0001581)1.89891658
103Abnormality of the pleura (HP:0002103)1.89698975
104Hepatitis (HP:0012115)1.88374022
105Recurrent otitis media (HP:0000403)1.88266183
106Colitis (HP:0002583)1.86535239
107Prolonged bleeding time (HP:0003010)1.85635569
108Fatigue (HP:0012378)1.84295092
109Emphysema (HP:0002097)1.81944853
110Urticaria (HP:0001025)1.81614455
111Genetic anticipation (HP:0003743)1.80254936
112Gastrointestinal stroma tumor (HP:0100723)1.79156363
113Episodic fever (HP:0001954)1.79080127
114Polyneuropathy (HP:0001271)1.78560628
115Hematochezia (HP:0002573)1.77587264
116Arthralgia (HP:0002829)1.76722478
117Dislocated radial head (HP:0003083)1.76046537
118Agammaglobulinemia (HP:0004432)1.75568710
119Keratitis (HP:0000491)1.75305635
120Abnormality of binocular vision (HP:0011514)1.74443192
121Diplopia (HP:0000651)1.74443192
122Abnormality of the endocardium (HP:0004306)1.74392353
123* Elevated erythrocyte sedimentation rate (HP:0003565)1.74011620

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TXK7.43742928
2MAP4K16.05594654
3JAK33.52474082
4ZAP703.30495132
5FGFR42.87523186
6* ITK2.73063324
7STK102.63470108
8MAP3K142.46072947
9IKBKE2.40297396
10RIPK42.37874737
11TYK22.31354342
12NLK2.21940159
13CAMKK22.18574621
14GRK62.16918817
15FGFR32.02128356
16PRPF4B1.99697760
17JAK11.87630142
18* LCK1.76072726
19EEF2K1.72172684
20CSK1.64138573
21CAMKK11.58764812
22MST41.55996082
23FRK1.55733130
24MAP3K101.47035598
25TBK11.41454324
26SYK1.34619846
27IKBKB1.33619140
28PRKCQ1.28158069
29PRKCH1.25376774
30MAP3K131.24227061
31CHUK1.23112401
32PIM11.12985881
33* HCK1.11591854
34CDK121.11180811
35MARK31.07663128
36MAP3K71.07044316
37JAK21.04282123
38NME21.03265849
39PKN21.01781775
40TSSK61.00720138
41PIK3CG1.00339125
42TYRO30.99875176
43TAOK10.98319982
44RPS6KA40.97031639
45EPHA30.96868758
46LRRK20.88221456
47EPHB10.86919525
48SIK20.81176209
49MAP2K30.76882031
50CLK10.76191442
51PDGFRB0.75804447
52TGFBR20.73359354
53IRAK40.73226816
54TRIB30.67531262
55CDK40.66546639
56BRD40.66323431
57BLK0.65859465
58TNK20.65231845
59MELK0.64806500
60SIK30.64709132
61FGFR10.62866252
62FES0.62816180
63KDR0.61216656
64KIT0.60372595
65ADRBK20.60061792
66LYN0.59943067
67SGK20.59717966
68MARK20.59449882
69BMPR20.58185588
70NEK60.57606925
71MAP3K10.55008432
72ALK0.54928868
73FGR0.54837600
74IRAK10.53573640
75MAP3K110.52335640
76HIPK20.52056158
77CSF1R0.50765840
78MAP2K60.50574831
79TESK20.50365751
80NUAK10.49057558
81PDK10.48459069
82PASK0.48312392
83RPS6KA50.46533909
84PRKD20.46398672
85MAPK70.45810669
86CDK90.43204368
87STK380.42913100
88* BTK0.42139073
89PIM20.41362660
90CAMK40.40827609
91TRPM70.40479152
92TTN0.40023443
93IGF1R0.39155545
94TAOK30.38068617
95WNK10.37809273
96GRK70.36220804
97FGFR20.35895094
98YES10.35659910
99STK40.35414261
100STK110.34560356
101CDK60.34547067
102FYN0.34263046
103MAP3K30.34123080
104PTK2B0.33624367
105PTK60.32906250
106MAP3K80.32555852
107NTRK20.32051416
108RAF10.31577887
109IRAK30.30467279
110* INSR0.29172636
111MAPK30.27852998
112SGK30.27542667
113TGFBR10.27059769
114SGK4940.25737941
115SGK2230.25737941
116MAPK40.25172315
117* TEC0.24778304
118DMPK0.24474309
119RPS6KA60.22890790
120RPS6KA10.22391325
121EGFR0.21717918
122MAPK120.21016953
123MAPKAPK20.20855067
124TAOK20.20591881
125ROCK20.19708416
126STK240.18919723
127MAPK110.17694817

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053405.35853126
2* T cell receptor signaling pathway_Homo sapiens_hsa046604.10510232
3Inflammatory bowel disease (IBD)_Homo sapiens_hsa053213.56734064
4Allograft rejection_Homo sapiens_hsa053303.37970975
5Graft-versus-host disease_Homo sapiens_hsa053323.13491777
6Intestinal immune network for IgA production_Homo sapiens_hsa046722.89994416
7Measles_Homo sapiens_hsa051622.85940682
8NF-kappa B signaling pathway_Homo sapiens_hsa040642.78973854
9Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.76310861
10Autoimmune thyroid disease_Homo sapiens_hsa053202.63225625
11Antigen processing and presentation_Homo sapiens_hsa046122.35642648
12Osteoclast differentiation_Homo sapiens_hsa043802.05605465
13Hematopoietic cell lineage_Homo sapiens_hsa046401.99581424
14Jak-STAT signaling pathway_Homo sapiens_hsa046301.97304093
15Leishmaniasis_Homo sapiens_hsa051401.87509218
16Type I diabetes mellitus_Homo sapiens_hsa049401.76847551
17Asthma_Homo sapiens_hsa053101.69159039
18Viral myocarditis_Homo sapiens_hsa054161.67698675
19RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.51962531
20Herpes simplex infection_Homo sapiens_hsa051681.51634246
21Acute myeloid leukemia_Homo sapiens_hsa052211.49727309
22B cell receptor signaling pathway_Homo sapiens_hsa046621.49492040
23Toxoplasmosis_Homo sapiens_hsa051451.44067649
24TNF signaling pathway_Homo sapiens_hsa046681.34772948
25NOD-like receptor signaling pathway_Homo sapiens_hsa046211.34771210
26Hepatitis B_Homo sapiens_hsa051611.30994676
27Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.30712917
28Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.29195451
29Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.28672142
30HTLV-I infection_Homo sapiens_hsa051661.23090144
31Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.19770894
32Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.19249015
33* Chemokine signaling pathway_Homo sapiens_hsa040621.15770545
34Chronic myeloid leukemia_Homo sapiens_hsa052201.12161868
35Prolactin signaling pathway_Homo sapiens_hsa049171.11285928
36Influenza A_Homo sapiens_hsa051641.09935162
37Pancreatic cancer_Homo sapiens_hsa052121.00479605
38Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.00200005
39Colorectal cancer_Homo sapiens_hsa052100.98409674
40Epstein-Barr virus infection_Homo sapiens_hsa051690.98299671
41Shigellosis_Homo sapiens_hsa051310.96313598
42Apoptosis_Homo sapiens_hsa042100.92937700
43Toll-like receptor signaling pathway_Homo sapiens_hsa046200.90712975
44AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.89016958
45* Leukocyte transendothelial migration_Homo sapiens_hsa046700.88633724
46Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.85152224
47Viral carcinogenesis_Homo sapiens_hsa052030.84082989
48Legionellosis_Homo sapiens_hsa051340.83320376
49Hepatitis C_Homo sapiens_hsa051600.79838176
50Platelet activation_Homo sapiens_hsa046110.72501798
51Transcriptional misregulation in cancer_Homo sapiens_hsa052020.70773764
52Malaria_Homo sapiens_hsa051440.69212262
53VEGF signaling pathway_Homo sapiens_hsa043700.66340203
54Regulation of autophagy_Homo sapiens_hsa041400.66263889
55Small cell lung cancer_Homo sapiens_hsa052220.63852050
56Spliceosome_Homo sapiens_hsa030400.63685451
57Neurotrophin signaling pathway_Homo sapiens_hsa047220.62620991
58Non-homologous end-joining_Homo sapiens_hsa034500.61032698
59Rheumatoid arthritis_Homo sapiens_hsa053230.60724914
60Tuberculosis_Homo sapiens_hsa051520.60610134
61Carbohydrate digestion and absorption_Homo sapiens_hsa049730.58789760
62MAPK signaling pathway_Homo sapiens_hsa040100.58774186
63Non-small cell lung cancer_Homo sapiens_hsa052230.57926359
64Thyroid cancer_Homo sapiens_hsa052160.57729352
65FoxO signaling pathway_Homo sapiens_hsa040680.56651978
66Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.56602843
67Staphylococcus aureus infection_Homo sapiens_hsa051500.55675498
68SNARE interactions in vesicular transport_Homo sapiens_hsa041300.54706803
69Circadian rhythm_Homo sapiens_hsa047100.54464947
70Ribosome_Homo sapiens_hsa030100.54328778
71Phosphatidylinositol signaling system_Homo sapiens_hsa040700.53813392
72Salmonella infection_Homo sapiens_hsa051320.53358007
73Endometrial cancer_Homo sapiens_hsa052130.49664744
74Prostate cancer_Homo sapiens_hsa052150.48840062
75Renal cell carcinoma_Homo sapiens_hsa052110.48367295
76Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.47888985
77p53 signaling pathway_Homo sapiens_hsa041150.47000226
78RNA degradation_Homo sapiens_hsa030180.45173312
79Notch signaling pathway_Homo sapiens_hsa043300.45136451
80Pertussis_Homo sapiens_hsa051330.44896119
81Phospholipase D signaling pathway_Homo sapiens_hsa040720.43293893
82Ras signaling pathway_Homo sapiens_hsa040140.42918573
83mTOR signaling pathway_Homo sapiens_hsa041500.42765675
84Adipocytokine signaling pathway_Homo sapiens_hsa049200.42519194
85mRNA surveillance pathway_Homo sapiens_hsa030150.42256381
86alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.40812608
87Endocytosis_Homo sapiens_hsa041440.40676367
88Type II diabetes mellitus_Homo sapiens_hsa049300.40072591
89Linoleic acid metabolism_Homo sapiens_hsa005910.38138831
90Regulation of actin cytoskeleton_Homo sapiens_hsa048100.37939384
91Insulin resistance_Homo sapiens_hsa049310.36702690
92Thyroid hormone signaling pathway_Homo sapiens_hsa049190.35479736
93Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.35407562
94HIF-1 signaling pathway_Homo sapiens_hsa040660.34398603
95MicroRNAs in cancer_Homo sapiens_hsa052060.34054154
96Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.32626649
97ABC transporters_Homo sapiens_hsa020100.31983034
98Inositol phosphate metabolism_Homo sapiens_hsa005620.31860286
99Glycerophospholipid metabolism_Homo sapiens_hsa005640.30898820
100Sphingolipid signaling pathway_Homo sapiens_hsa040710.30381826
101Pathways in cancer_Homo sapiens_hsa052000.30073973
102Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.29595803
103Rap1 signaling pathway_Homo sapiens_hsa040150.29424025
104Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.28773380
105Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.27999198
106Long-term potentiation_Homo sapiens_hsa047200.26320206
107Glycerolipid metabolism_Homo sapiens_hsa005610.25827437
108Cholinergic synapse_Homo sapiens_hsa047250.24181630
109Longevity regulating pathway - mammal_Homo sapiens_hsa042110.24131083
110Morphine addiction_Homo sapiens_hsa050320.23110958
111Dorso-ventral axis formation_Homo sapiens_hsa043200.22979836
112Choline metabolism in cancer_Homo sapiens_hsa052310.22889738
113RNA transport_Homo sapiens_hsa030130.21318974
114Adherens junction_Homo sapiens_hsa045200.20714664
115GnRH signaling pathway_Homo sapiens_hsa049120.20675630
116Oxytocin signaling pathway_Homo sapiens_hsa049210.20345653
117Vascular smooth muscle contraction_Homo sapiens_hsa042700.20046508
118African trypanosomiasis_Homo sapiens_hsa051430.18033703
119Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.17384870
120ErbB signaling pathway_Homo sapiens_hsa040120.16863697
121Base excision repair_Homo sapiens_hsa034100.16153251
122Lysine degradation_Homo sapiens_hsa003100.14302572

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