ITLN1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of respiratory burst (GO:0060267)8.67957699
2angiotensin maturation (GO:0002003)8.26682684
3killing of cells of other organism (GO:0031640)8.11710003
4disruption of cells of other organism (GO:0044364)8.11710003
5defense response to fungus (GO:0050832)8.05588304
6antibacterial humoral response (GO:0019731)7.53195157
7antimicrobial humoral response (GO:0019730)7.32529589
8glomerular filtration (GO:0003094)7.13035550
9renal filtration (GO:0097205)6.49431375
10regulation of bile acid biosynthetic process (GO:0070857)6.49076477
11regulation of guanylate cyclase activity (GO:0031282)6.15510033
12bundle of His cell to Purkinje myocyte communication (GO:0086069)5.81450625
13vitamin A metabolic process (GO:0006776)5.79083042
14regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)5.74971305
15regulation of respiratory burst (GO:0060263)5.73318563
16digestive system process (GO:0022600)5.59278791
17UDP-N-acetylglucosamine metabolic process (GO:0006047)5.58215752
18actin filament depolymerization (GO:0030042)5.57785384
19intestinal epithelial cell development (GO:0060576)5.44556641
20flavonoid metabolic process (GO:0009812)5.38990071
21positive regulation of pseudopodium assembly (GO:0031274)5.30131499
22adhesion of symbiont to host cell (GO:0044650)4.92705040
23virion attachment to host cell (GO:0019062)4.92705040
24regulation of systemic arterial blood pressure by hormone (GO:0001990)4.91353386
25regulation of systemic arterial blood pressure mediated by a chemical signal (GO:0003044)4.91353386
26endocrine process (GO:0050886)4.91353386
27innate immune response in mucosa (GO:0002227)4.87975892
28oligosaccharide biosynthetic process (GO:0009312)4.86258932
29glucose 6-phosphate metabolic process (GO:0051156)4.78365486
30regulation of pseudopodium assembly (GO:0031272)4.75729559
31drug catabolic process (GO:0042737)4.66201184
32transepithelial transport (GO:0070633)4.59241656
33positive regulation of guanylate cyclase activity (GO:0031284)4.51609676
34membrane repolarization during cardiac muscle cell action potential (GO:0086013)4.46307470
35response to fungus (GO:0009620)4.41953928
36regulation of vitamin metabolic process (GO:0030656)4.31534853
37regulation of systemic arterial blood pressure (GO:0003073)4.29682633
38renal system process involved in regulation of blood volume (GO:0001977)4.22291189
39purine ribonucleoside bisphosphate metabolic process (GO:0034035)4.18584325
403-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)4.18584325
41urea metabolic process (GO:0019627)4.17573546
42urea cycle (GO:0000050)4.17573546
43lipoprotein metabolic process (GO:0042157)4.15553221
44NADH metabolic process (GO:0006734)4.13610378
45mucosal immune response (GO:0002385)4.08324420
46sperm capacitation (GO:0048240)4.07339051
47response to hepatocyte growth factor (GO:0035728)4.05788465
48cellular response to hepatocyte growth factor stimulus (GO:0035729)4.05788465
49bicarbonate transport (GO:0015701)4.05055415
50plasma lipoprotein particle assembly (GO:0034377)4.02175427
51cellular glucuronidation (GO:0052695)3.98023880
52regulation of cholesterol homeostasis (GO:2000188)3.94435209
53maintenance of gastrointestinal epithelium (GO:0030277)3.94217224
54triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.94165628
55protein-lipid complex assembly (GO:0065005)3.93567614
56adhesion of symbiont to host (GO:0044406)3.93396945
57membrane repolarization during action potential (GO:0086011)3.92705329
58complement activation, classical pathway (GO:0006958)3.89616468
59uronic acid metabolic process (GO:0006063)3.89335570
60glucuronate metabolic process (GO:0019585)3.89335570
61regulation of Golgi to plasma membrane protein transport (GO:0042996)3.87578080
62digestion (GO:0007586)3.86525521
63regulation of cGMP biosynthetic process (GO:0030826)3.86388740
64organ or tissue specific immune response (GO:0002251)3.84585259
65regulation of triglyceride catabolic process (GO:0010896)3.82119274
66modified amino acid transport (GO:0072337)3.80355082
67phospholipid efflux (GO:0033700)3.76534384
68regulation of cholesterol esterification (GO:0010872)3.75141707
69hormone catabolic process (GO:0042447)3.73785674
70very-low-density lipoprotein particle assembly (GO:0034379)3.72712322
71ethanol oxidation (GO:0006069)3.72142927
72bile acid and bile salt transport (GO:0015721)3.70985402
73nitrogen cycle metabolic process (GO:0071941)3.68365002
74cholesterol homeostasis (GO:0042632)3.68339876
75epoxygenase P450 pathway (GO:0019373)3.66101883
76cell killing (GO:0001906)3.65705874
77ethanol metabolic process (GO:0006067)3.65607896
78regulation of cellular extravasation (GO:0002691)3.65392885
79sterol homeostasis (GO:0055092)3.64701771
80cGMP-mediated signaling (GO:0019934)3.60301769
81cGMP biosynthetic process (GO:0006182)3.60129526
82diacylglycerol metabolic process (GO:0046339)3.59004313
83transcytosis (GO:0045056)3.56791082
84ventricular cardiac muscle cell action potential (GO:0086005)3.55422986
85primary alcohol catabolic process (GO:0034310)3.53341533
86antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.48284138
87lipoprotein transport (GO:0042953)3.48198380
88positive regulation of lipoprotein lipase activity (GO:0051006)3.48071175
89positive regulation of triglyceride lipase activity (GO:0061365)3.48071175
90eosinophil chemotaxis (GO:0048245)3.46907240
91nucleoside diphosphate biosynthetic process (GO:0009133)3.45460312
92sterol transport (GO:0015918)3.43871163
93cholesterol transport (GO:0030301)3.43871163
94sulfate transmembrane transport (GO:1902358)3.42947996
95cholesterol efflux (GO:0033344)3.41846258
96antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.39737213
97homocysteine metabolic process (GO:0050667)3.37451582
98intracellular estrogen receptor signaling pathway (GO:0030520)3.33883209
99peptide catabolic process (GO:0043171)3.33328538
100sulfate transport (GO:0008272)3.33191724
101fat-soluble vitamin biosynthetic process (GO:0042362)3.33036229
102O-glycan processing (GO:0016266)3.30770733
103peptide hormone processing (GO:0016486)3.26131342
104filopodium assembly (GO:0046847)3.24944162
105striated muscle atrophy (GO:0014891)3.23133269
106receptor guanylyl cyclase signaling pathway (GO:0007168)3.22724808
107calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)3.22108659
108epithelial structure maintenance (GO:0010669)3.22001532
109antigen processing and presentation of endogenous antigen (GO:0019883)3.18590181
110glucocorticoid biosynthetic process (GO:0006704)3.16792909
111desmosome organization (GO:0002934)3.16727273
112drinking behavior (GO:0042756)3.15460052
113regulation of cGMP metabolic process (GO:0030823)3.14411564
114fructose metabolic process (GO:0006000)3.14267032
115negative regulation of sterol transport (GO:0032372)3.13633662
116negative regulation of cholesterol transport (GO:0032375)3.13633662
117positive regulation of Cdc42 GTPase activity (GO:0043089)3.12293126
118glycosphingolipid catabolic process (GO:0046479)3.12192290
119positive regulation of glycoprotein biosynthetic process (GO:0010560)3.11384113
120alkaloid metabolic process (GO:0009820)3.09931942
121proline biosynthetic process (GO:0006561)3.08924492
122positive regulation of fatty acid beta-oxidation (GO:0032000)3.08073447
123eosinophil migration (GO:0072677)3.07881104
124sulfation (GO:0051923)3.07312481
125complement activation (GO:0006956)3.06204247
126sulfur compound transport (GO:0072348)3.05539791
127endocrine pancreas development (GO:0031018)3.05414245
128negative regulation of myotube differentiation (GO:0010832)3.04965814
129regulation of digestive system process (GO:0044058)3.03679911
130phospholipid scrambling (GO:0017121)3.03555098
131renal system process involved in regulation of systemic arterial blood pressure (GO:0003071)3.03343084
132glycolipid catabolic process (GO:0019377)3.03054096
133arginine metabolic process (GO:0006525)3.02815328
134regulation of calcineurin-NFAT signaling cascade (GO:0070884)3.01276683
135GDP-mannose metabolic process (GO:0019673)3.00656535
136tight junction assembly (GO:0070830)3.00020077
137phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)2.99642683
138regulation of actin nucleation (GO:0051125)2.99441639
139protein targeting to Golgi (GO:0000042)2.98868547
140positive regulation of glycoprotein metabolic process (GO:1903020)2.95666689
141thyroid hormone metabolic process (GO:0042403)2.95621106
142negative regulation of steroid metabolic process (GO:0045939)2.93709375
143positive regulation of establishment of protein localization to plasma membrane (GO:0090004)2.93511982
144cellular response to pH (GO:0071467)2.89118606
145labyrinthine layer development (GO:0060711)2.86590619
146glycosylceramide metabolic process (GO:0006677)2.86544124
147sodium ion homeostasis (GO:0055078)2.83479065
148auditory receptor cell differentiation (GO:0042491)2.76356570
149sexual reproduction (GO:0019953)2.75885518
150positive regulation of cGMP biosynthetic process (GO:0030828)2.73498450
151receptor recycling (GO:0001881)2.71902705
152nucleotide-sugar biosynthetic process (GO:0009226)2.69987160
153arginine catabolic process (GO:0006527)2.64969591
154thrombin receptor signaling pathway (GO:0070493)2.64404633
155drug metabolic process (GO:0017144)2.63745307
156fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.63292381
157positive regulation of systemic arterial blood pressure (GO:0003084)2.61720289
158negative regulation of leukocyte chemotaxis (GO:0002689)2.57277429
159intestinal absorption (GO:0050892)12.0078215
160intestinal cholesterol absorption (GO:0030299)10.2385966

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human8.90154072
2CDX2_20551321_ChIP-Seq_CACO-2_Human6.01691285
3* SOX2_27498859_Chip-Seq_STOMACH_Mouse4.17633036
4GATA4_25053715_ChIP-Seq_YYC3_Human3.38588158
5HNF4A_19761587_ChIP-ChIP_CACO-2_Human3.21014212
6* GATA6_25053715_ChIP-Seq_YYC3_Human3.16133159
7ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.92675592
8SOX2_20726797_ChIP-Seq_SW620_Human2.83435122
9PPARA_22158963_ChIP-Seq_LIVER_Mouse2.79227953
10IRF8_22096565_ChIP-ChIP_GC-B_Human2.70055233
11TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.65151926
12SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.54360485
13LXR_22158963_ChIP-Seq_LIVER_Mouse2.49692240
14GATA1_22025678_ChIP-Seq_K562_Human2.37217776
15RXR_22158963_ChIP-Seq_LIVER_Mouse2.30366424
16BP1_19119308_ChIP-ChIP_Hs578T_Human2.15853665
17PPAR_26484153_Chip-Seq_NCI-H1993_Human2.15476183
18CDX2_19796622_ChIP-Seq_MESCs_Mouse2.14281427
19STAT6_21828071_ChIP-Seq_BEAS2B_Human2.13510677
20FOXO3_23340844_ChIP-Seq_DLD1_Human2.03869777
21TRIM28_21343339_ChIP-Seq_HEK293_Human1.98008373
22CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.95369265
23RUNX1_27514584_Chip-Seq_MCF-7_Human1.94403128
24FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.93526386
25KLF5_25053715_ChIP-Seq_YYC3_Human1.90611020
26TCF4_18268006_ChIP-ChIP_LS174T_Human1.87214675
27KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.84102212
28NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.80110091
29PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.78584375
30ESR2_21235772_ChIP-Seq_MCF-7_Human1.74262984
31STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.72565198
32TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.71577636
33RARG_19884340_ChIP-ChIP_MEFs_Mouse1.70495144
34PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.66590531
35AR_21909140_ChIP-Seq_LNCAP_Human1.66042534
36ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.64687991
37PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.64357123
38ZNF263_19887448_ChIP-Seq_K562_Human1.64051425
39CTNNB1_20460455_ChIP-Seq_HCT116_Human1.63676377
40KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.63610820
41ZNF217_24962896_ChIP-Seq_MCF-7_Human1.63553167
42FOXA2_19822575_ChIP-Seq_HepG2_Human1.52707938
43CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.52145901
44ATF3_27146783_Chip-Seq_COLON_Human1.50625948
45HNF4A_19822575_ChIP-Seq_HepG2_Human1.49013058
46FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.46200550
47TP53_16413492_ChIP-PET_HCT116_Human1.43182690
48RACK7_27058665_Chip-Seq_MCF-7_Human1.41471251
49NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.40057066
50* ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.39784437
51PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.38428947
52RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.37676263
53HIF1A_21447827_ChIP-Seq_MCF-7_Human1.35218148
54BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.35001061
55NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.33656292
56TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.26093664
57GATA2_19941826_ChIP-Seq_K562_Human1.25577117
58SRY_22984422_ChIP-ChIP_TESTIS_Rat1.25377883
59AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.19785616
60RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.17105824
61SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.16702470
62ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.16078964
63BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.15188643
64ESR1_21235772_ChIP-Seq_MCF-7_Human1.14901984
65CREB1_26743006_Chip-Seq_LNCaP_Human1.14803248
66VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.14639575
67ESR1_20079471_ChIP-ChIP_T-47D_Human1.12372948
68JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse1.11525845
69* FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.10151384
70DROSHA_22980978_ChIP-Seq_HELA_Human1.10085426
71* EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.09466427
72MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.09431244
73SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.08831790
74SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.08831790
75SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.07125175
76EGR1_19032775_ChIP-ChIP_M12_Human1.06785069
77GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.06555950
78SOX9_24532713_ChIP-Seq_HFSC_Mouse1.06494810
79CLOCK_20551151_ChIP-Seq_293T_Human1.05329506
80EGR1_23403033_ChIP-Seq_LIVER_Mouse1.04137320
81FOXM1_26456572_ChIP-Seq_MCF-7_Human1.00725201
82SMAD3_21741376_ChIP-Seq_HESCs_Human1.00282839
83TET1_21451524_ChIP-Seq_MESCs_Mouse0.99723556
84IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.96921658
85STAT3_20064451_ChIP-Seq_CD4+T_Mouse0.96693391
86SA1_27219007_Chip-Seq_Bcells_Human0.96610152
87FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.96303942
88ERG_21242973_ChIP-ChIP_JURKAT_Human0.95073418
89CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.94168965
90SALL4_18804426_ChIP-ChIP_XEN_Mouse0.93588681
91* TBX20_22080862_ChIP-Seq_HEART_Mouse0.92495842
92* TBX20_22328084_ChIP-Seq_HEART_Mouse0.92495842
93NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.92341257
94GATA1_26923725_Chip-Seq_HPCs_Mouse0.92325221
95BCL6_27268052_Chip-Seq_Bcells_Human0.92241874
96JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.91497086
97VDR_24763502_ChIP-Seq_THP-1_Human0.91082462
98CEBPB_22108803_ChIP-Seq_LS180_Human0.90314062
99SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.89432143
100RAD21_21589869_ChIP-Seq_MESCs_Mouse0.88660561
101ELK3_25401928_ChIP-Seq_HUVEC_Human0.87919172
102EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.87462449
103THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.86859862
104FOXA1_25552417_ChIP-Seq_VCAP_Human0.86711184
105TCF3_18692474_ChIP-Seq_MEFs_Mouse0.85929287
106GATA1_22383799_ChIP-Seq_G1ME_Mouse0.85853555
107SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.85711682
108ELF5_23300383_ChIP-Seq_T47D_Human0.85556556
109Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.85026282
110* CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.85009539
111GATA3_24758297_ChIP-Seq_MCF-7_Human0.84960998
112LXR_22292898_ChIP-Seq_THP-1_Human0.84526756
113TCF7L2_21901280_ChIP-Seq_H4IIE_Rat0.83036975
114ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.82737839
115GATA1_19941826_ChIP-Seq_K562_Human0.82678932
116CDX2_22108803_ChIP-Seq_LS180_Human0.82544397
117DNAJC2_21179169_ChIP-ChIP_NT2_Human0.81991668
118STAT1_20625510_ChIP-Seq_HELA_Human0.81879076
119SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse0.81812948
120TP63_23658742_ChIP-Seq_EP156T_Human0.80815644
121BCAT_22108803_ChIP-Seq_LS180_Human0.80424718
122GATA2_21666600_ChIP-Seq_HMVEC_Human0.80178256
123UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.78014687
124TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.77688816
125BCOR_27268052_Chip-Seq_Bcells_Human0.77570233
126FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.77253594
127NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.75488364
128ISL1_27105846_Chip-Seq_CPCs_Mouse0.75426090
129P63_26484246_Chip-Seq_KERATINOCYTES_Human0.75174804
130* STAT1_17558387_ChIP-Seq_HELA_Human0.74668019
131P300_27058665_Chip-Seq_ZR-75-30cells_Human0.73901927
132KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.73695200
133CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.72590641
134SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.71009951
135TP63_22573176_ChIP-Seq_HFKS_Human0.70977855
136CTCF_27219007_Chip-Seq_Bcells_Human0.70785929
137PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.70080299

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005360_urolithiasis8.35096496
2MP0001666_abnormal_nutrient_absorption5.32415600
3MP0010234_abnormal_vibrissa_follicle4.47873409
4MP0004264_abnormal_extraembryonic_tissu3.96776995
5MP0000462_abnormal_digestive_system3.82231965
6MP0002139_abnormal_hepatobiliary_system3.76324075
7MP0005085_abnormal_gallbladder_physiolo3.48914157
8MP0003300_gastrointestinal_ulcer3.17844489
9MP0003866_abnormal_defecation3.09414724
10MP0003183_abnormal_peptide_metabolism2.95959109
11MP0009840_abnormal_foam_cell2.89083947
12MP0003252_abnormal_bile_duct2.87168356
13MP0001873_stomach_inflammation2.58295785
14MP0000537_abnormal_urethra_morphology2.57079783
15MP0005365_abnormal_bile_salt2.33296227
16MP0001663_abnormal_digestive_system2.32302802
17MP0010155_abnormal_intestine_physiology2.31478078
18MP0010352_gastrointestinal_tract_polyps2.28145332
19MP0010329_abnormal_lipoprotein_level2.27037952
20MP0008004_abnormal_stomach_pH2.20617773
21MP0005381_digestive/alimentary_phenotyp2.18715033
22MP0008875_abnormal_xenobiotic_pharmacok2.12980218
23MP0000490_abnormal_crypts_of2.06540263
24MP0002822_catalepsy2.03907361
25MP0009379_abnormal_foot_pigmentation2.00620542
26MP0001664_abnormal_digestion1.96553996
27MP0004858_abnormal_nervous_system1.94882103
28MP0005409_darkened_coat_color1.93034852
29MP0000477_abnormal_intestine_morphology1.91791987
30MP0003724_increased_susceptibility_to1.85931411
31MP0004019_abnormal_vitamin_homeostasis1.82586179
32MP0004782_abnormal_surfactant_physiolog1.77223943
33MP0005670_abnormal_white_adipose1.75323933
34MP0000538_abnormal_urinary_bladder1.74898063
35MP0004147_increased_porphyrin_level1.66949245
36MP0002254_reproductive_system_inflammat1.65805219
37MP0002138_abnormal_hepatobiliary_system1.65033211
38MP0000465_gastrointestinal_hemorrhage1.52440821
39MP0003705_abnormal_hypodermis_morpholog1.48272602
40MP0009780_abnormal_chondrocyte_physiolo1.35886674
41MP0003303_peritoneal_inflammation1.35209222
42MP0002796_impaired_skin_barrier1.32876439
43MP0002089_abnormal_postnatal_growth/wei1.31672105
44MP0002166_altered_tumor_susceptibility1.26711181
45MP0004043_abnormal_pH_regulation1.26248814
46MP0003878_abnormal_ear_physiology1.25675925
47MP0005377_hearing/vestibular/ear_phenot1.25675925
48MP0005084_abnormal_gallbladder_morpholo1.25446674
49MP0005448_abnormal_energy_balance1.24358291
50MP0008872_abnormal_physiological_respon1.22880848
51MP0005451_abnormal_body_composition1.22337824
52MP0002277_abnormal_respiratory_mucosa1.19759575
53MP0000230_abnormal_systemic_arterial1.17964269
54MP0006054_spinal_hemorrhage1.14073862
55MP0005165_increased_susceptibility_to1.13404743
56MP0002163_abnormal_gland_morphology1.12490166
57MP0005387_immune_system_phenotype1.10767540
58MP0001790_abnormal_immune_system1.10767540
59MP0000613_abnormal_salivary_gland1.08083662
60MP0003436_decreased_susceptibility_to1.07394642
61MP0010678_abnormal_skin_adnexa1.07214829
62MP0002009_preneoplasia1.05610384
63MP0001849_ear_inflammation1.04731081
64MP0009785_altered_susceptibility_to1.02892399
65MP0009643_abnormal_urine_homeostasis1.02424009
66MP0001485_abnormal_pinna_reflex1.00954853
67MP0001756_abnormal_urination1.00030314
68MP0008775_abnormal_heart_ventricle1.00021901
69MP0004215_abnormal_myocardial_fiber0.99962941
70MP0003806_abnormal_nucleotide_metabolis0.99955103
71MP0005025_abnormal_response_to0.99797907
72MP0000566_synostosis0.99052285
73MP0001845_abnormal_inflammatory_respons0.98873353
74MP0001188_hyperpigmentation0.98371610
75MP0003693_abnormal_embryo_hatching0.97914103
76MP0009053_abnormal_anal_canal0.97126165
77MP0001533_abnormal_skeleton_physiology0.96409953
78MP0009384_cardiac_valve_regurgitation0.95296415
79MP0003329_amyloid_beta_deposits0.93241259
80MP0002896_abnormal_bone_mineralization0.93204539
81MP0000470_abnormal_stomach_morphology0.91568602
82MP0004270_analgesia0.90059491
83MP0002098_abnormal_vibrissa_morphology0.89557167
84MP0005332_abnormal_amino_acid0.89228211
85MP0003453_abnormal_keratinocyte_physiol0.88492837
86MP0004484_altered_response_of0.88294303
87MP0000609_abnormal_liver_physiology0.85887450
88MP0002006_tumorigenesis0.85120994
89MP0002118_abnormal_lipid_homeostasis0.84976069
90MP0002132_abnormal_respiratory_system0.82535625
91MP0003119_abnormal_digestive_system0.82202728
92MP0005666_abnormal_adipose_tissue0.81518562
93MP0002971_abnormal_brown_adipose0.80443795
94MP0005166_decreased_susceptibility_to0.80154884
95MP0000249_abnormal_blood_vessel0.79843012
96MP0005501_abnormal_skin_physiology0.79671288
97MP0001765_abnormal_ion_homeostasis0.79255600
98MP0001501_abnormal_sleep_pattern0.77604916
99MP0003283_abnormal_digestive_organ0.77505696
100MP0000467_abnormal_esophagus_morphology0.76696391
101MP0006082_CNS_inflammation0.75843653
102MP0004947_skin_inflammation0.75219637
103MP0002998_abnormal_bone_remodeling0.74919420
104MP0009115_abnormal_fat_cell0.74110711
105MP0000516_abnormal_urinary_system0.73089786
106MP0005367_renal/urinary_system_phenotyp0.73089786
107MP0005058_abnormal_lysosome_morphology0.70564748
108MP0002876_abnormal_thyroid_physiology0.68034170
109MP0001835_abnormal_antigen_presentation0.67375842
110MP0005023_abnormal_wound_healing0.67143502
111MP0000604_amyloidosis0.67084287
112MP0009697_abnormal_copulation0.65519051
113MP0001216_abnormal_epidermal_layer0.63796324
114MP0005167_abnormal_blood-brain_barrier0.63648232
115MP0003315_abnormal_perineum_morphology0.61724982
116MP0001544_abnormal_cardiovascular_syste0.60788132
117MP0005385_cardiovascular_system_phenoty0.60788132
118MP0003075_altered_response_to0.60757278
119MP0000013_abnormal_adipose_tissue0.60280500
120MP0003868_abnormal_feces_composition0.60224793
121MP0006138_congestive_heart_failure0.60204872
122MP0002148_abnormal_hypersensitivity_rea0.60023066
123MP0005636_abnormal_mineral_homeostasis0.58900263
124MP0005319_abnormal_enzyme/_coenzyme0.57502520
125MP0000678_abnormal_parathyroid_gland0.57358001
126MP0001764_abnormal_homeostasis0.56631948
127MP0010386_abnormal_urinary_bladder0.56388099
128MP0003718_maternal_effect0.56318437
129MP0003191_abnormal_cellular_cholesterol0.54723676
130MP0005187_abnormal_penis_morphology0.53832301
131MP0005266_abnormal_metabolism0.51797971
132MP0005310_abnormal_salivary_gland0.51185741
133MP0003950_abnormal_plasma_membrane0.51042119
134MP0002136_abnormal_kidney_physiology0.48855486
135MP0009765_abnormal_xenobiotic_induced0.48585115
136MP0003879_abnormal_hair_cell0.47912785
137MP0000579_abnormal_nail_morphology0.45102096
138MP0002060_abnormal_skin_morphology0.41728841
139MP0009642_abnormal_blood_homeostasis0.40982612
140MP0005379_endocrine/exocrine_gland_phen0.40920333
141MP0003638_abnormal_response/metabolism_0.39711686
142MP0003045_fibrosis0.38836655
143MP0001191_abnormal_skin_condition0.37589388
144MP0005584_abnormal_enzyme/coenzyme_acti0.35804329
145MP0003787_abnormal_imprinting0.35723134

Predicted human phenotypes

RankGene SetZ-score
1Hyperactive renin-angiotensin system (HP:0000841)7.49425583
2Decreased circulating renin level (HP:0003351)6.33362390
3Abnormality of glutamine family amino acid metabolism (HP:0010902)6.17469085
4Conjugated hyperbilirubinemia (HP:0002908)5.98037631
5Right ventricular cardiomyopathy (HP:0011663)5.95749308
6Acanthocytosis (HP:0001927)5.75138217
7Malnutrition (HP:0004395)5.73498118
8Metabolic alkalosis (HP:0200114)5.70814951
9Abnormality of renin-angiotensin system (HP:0000847)5.39397984
10Hypobetalipoproteinemia (HP:0003563)5.37324728
11Rectal prolapse (HP:0002035)4.79785969
12Congenital sensorineural hearing impairment (HP:0008527)4.55180060
13Alkalosis (HP:0001948)4.50271708
14Ventricular fibrillation (HP:0001663)4.31130687
15Systemic lupus erythematosus (HP:0002725)4.29599545
16Fat malabsorption (HP:0002630)4.04059431
17Abdominal distention (HP:0003270)3.98209218
18Pigmentary retinal degeneration (HP:0001146)3.80962605
19Gastrointestinal dysmotility (HP:0002579)3.76457369
20Chronic diarrhea (HP:0002028)3.72432277
21Abnormal biliary tract morphology (HP:0012440)3.71953542
22Hyperaldosteronism (HP:0000859)3.66936765
23Abnormality of proline metabolism (HP:0010907)3.62918030
24Hydroxyprolinuria (HP:0003080)3.62918030
25Abnormality of the vitamin B12 metabolism (HP:0004341)3.59030070
26Intrahepatic cholestasis (HP:0001406)3.53247604
27Autoimmune thrombocytopenia (HP:0001973)3.47661998
28Abnormality of urine glucose concentration (HP:0011016)3.45963338
29Glycosuria (HP:0003076)3.45963338
30Hemorrhage of the eye (HP:0011885)3.39307838
31Widely patent fontanelles and sutures (HP:0004492)3.37538093
32Abnormality of vitamin B metabolism (HP:0004340)3.33150808
33Poikilocytosis (HP:0004447)3.28102800
34Abnormality of monocarboxylic acid metabolism (HP:0010996)3.23565205
35Villous atrophy (HP:0011473)3.20846974
36Abnormality of small intestinal villus morphology (HP:0011472)3.20846974
37Male infertility (HP:0003251)3.20361040
38Dehydration (HP:0001944)3.18221774
39Abnormality of the gastric mucosa (HP:0004295)3.10127332
40Abnormal glucose tolerance (HP:0001952)3.04644270
41Autoimmune hemolytic anemia (HP:0001890)2.99545427
42Abnormality of complement system (HP:0005339)2.97692727
43Abnormality of vitamin metabolism (HP:0100508)2.94176611
44Abnormal tarsal ossification (HP:0008369)2.91592447
45Hypokalemia (HP:0002900)2.90702788
46Abnormality of chloride homeostasis (HP:0011422)2.89777284
47Hyponatremia (HP:0002902)2.87942898
48Complement deficiency (HP:0004431)2.87167488
49Hypolipoproteinemia (HP:0010981)2.86938752
50Eczematoid dermatitis (HP:0000976)2.86221441
51Progressive sensorineural hearing impairment (HP:0000408)2.84957480
52Mildly elevated creatine phosphokinase (HP:0008180)2.81452459
53Pustule (HP:0200039)2.78892324
54Syncope (HP:0001279)2.78862626
55Increased mean platelet volume (HP:0011877)2.77922130
56Glomerulonephritis (HP:0000099)2.73647577
57Abnormality of the distal phalanx of the thumb (HP:0009617)2.72300579
58Flattened epiphyses (HP:0003071)2.70780316
59Cupped ribs (HP:0000887)2.66851088
60Abnormality of potassium homeostasis (HP:0011042)2.62443451
61Late onset (HP:0003584)2.56493528
62Progressive hearing impairment (HP:0001730)2.53014127
63Wide cranial sutures (HP:0010537)2.51629346
64Biliary tract neoplasm (HP:0100574)2.51566755
65Woolly hair (HP:0002224)2.50959875
66Palpitations (HP:0001962)2.44811775
67Potter facies (HP:0002009)2.40554283
68Facial shape deformation (HP:0011334)2.40554283
69Micronodular cirrhosis (HP:0001413)2.40478946
70Pili torti (HP:0003777)2.40237348
71Fragile skin (HP:0001030)2.40208471
72Abnormal platelet volume (HP:0011876)2.38369318
73Nephritis (HP:0000123)2.38080682
74Hyperkalemia (HP:0002153)2.37846975
75Visceral angiomatosis (HP:0100761)2.37025354
76Uterine neoplasm (HP:0010784)2.28113931
77Prolonged QT interval (HP:0001657)2.28085826
78Nephrolithiasis (HP:0000787)2.28081021
79Milia (HP:0001056)2.27904703
80Hypotension (HP:0002615)2.27220562
81Abnormality of carpal bone ossification (HP:0006257)2.27198885
82Neonatal short-limb short stature (HP:0008921)2.25317696
83Posterior subcapsular cataract (HP:0007787)2.24426576
84Hyperphosphaturia (HP:0003109)2.24424254
85Abnormality of sodium homeostasis (HP:0010931)2.23989291
86Abnormality of the 1st metacarpal (HP:0010009)2.21496296
87Thin bony cortex (HP:0002753)2.20670046
88Adrenal overactivity (HP:0002717)2.20429974
89Hypercholesterolemia (HP:0003124)2.19804367
90Bundle branch block (HP:0011710)2.18275224
91Hereditary nonpolyposis colorectal carcinoma (HP:0006716)2.17374639
92Confusion (HP:0001289)2.15664297
93Exocrine pancreatic insufficiency (HP:0001738)2.11964617
94Hyperglycinuria (HP:0003108)2.09511725
95Hemangiomatosis (HP:0007461)2.08744411
96Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.08344716
97Gastrointestinal carcinoma (HP:0002672)2.07246702
98Malignant gastrointestinal tract tumors (HP:0006749)2.07246702
99Nausea (HP:0002018)2.05728827
100Abnormality of purine metabolism (HP:0004352)2.05242312
101Hyperbilirubinemia (HP:0002904)2.04184384
102Ventricular arrhythmia (HP:0004308)2.03853657
103Urethral obstruction (HP:0000796)2.03060337
104Hypercalciuria (HP:0002150)2.02557297
105Hyperammonemia (HP:0001987)2.01472434
106Reticulocytosis (HP:0001923)2.00600821
107Dicarboxylic aciduria (HP:0003215)2.00508764
108Abnormality of dicarboxylic acid metabolism (HP:0010995)2.00508764
109Ileus (HP:0002595)11.1649587
110Abnormal hair laboratory examination (HP:0003328)1.98522038
111Growth hormone excess (HP:0000845)1.97344179
112Focal segmental glomerulosclerosis (HP:0000097)1.97161389
113Cerebral palsy (HP:0100021)1.95200789
114Neoplasm of the small intestine (HP:0100833)1.95082284
115Spontaneous hematomas (HP:0007420)1.94430459
116Microretrognathia (HP:0000308)1.94143841
117Abnormal foot bone ossification (HP:0010675)1.93562327
118Proximal tubulopathy (HP:0000114)1.93415358
119Neoplasm of the rectum (HP:0100743)1.93085523
120Abnormal urine phosphate concentration (HP:0012599)1.90094383
121Abnormality of the right ventricle (HP:0001707)1.89737756
122Hematochezia (HP:0002573)1.88988424
123Metabolic acidosis (HP:0001942)1.88797763
124Xanthomatosis (HP:0000991)1.88399403
125Symptomatic seizures (HP:0011145)1.87694695
126Ventricular tachycardia (HP:0004756)1.87657697
127Partial duplication of thumb phalanx (HP:0009944)1.87482134
128Hyperparathyroidism (HP:0000843)1.86291904
129Abnormality of aspartate family amino acid metabolism (HP:0010899)1.85735881
130Goiter (HP:0000853)1.85475657
131Abnormality of the nasal mucosa (HP:0000433)1.85218241
132Renal tubular acidosis (HP:0001947)1.84811893
133Amyloidosis (HP:0011034)1.84270583
134Ankyloglossia (HP:0010296)1.84116317
135Gingivitis (HP:0000230)1.81723238
136Flat capital femoral epiphysis (HP:0003370)1.81177653
137Petechiae (HP:0000967)1.80738841
138Curly hair (HP:0002212)1.80662680
139Flat acetabular roof (HP:0003180)1.79835451
140Hyperphosphatemia (HP:0002905)1.79746888
141Protuberant abdomen (HP:0001538)1.79158648
142Polycythemia (HP:0001901)1.77714434
143Abnormal ossification of hand bones (HP:0005921)1.77225770
144Abnormal hand bone ossification (HP:0010660)1.76884253
145Severe short stature (HP:0003510)1.76681239
146Abnormality of sulfur amino acid metabolism (HP:0004339)1.75871265
147Distal lower limb amyotrophy (HP:0008944)1.73202771
148Pancreatitis (HP:0001733)1.72823779
149Plantar hyperkeratosis (HP:0007556)1.72525256
150Mesangial abnormality (HP:0001966)1.72298120
151Bone pain (HP:0002653)1.70306720
152Chorioretinal atrophy (HP:0000533)1.69599267
153Hypophosphatemia (HP:0002148)1.69536582
154Segmental peripheral demyelination/remyelination (HP:0003481)1.68414462

Predicted kinase interactions (KEA)

RankGene SetZ-score
1LMTK29.02438962
2FRK6.03108268
3ACVR1B5.25462131
4PRKG24.16431682
5MST44.15998619
6MST1R3.77406993
7EPHA22.89004372
8NME12.43430688
9GRK62.30140199
10RIPK12.17861983
11MAP2K22.16605086
12MAP3K102.10549421
13NUAK12.08943395
14EPHA32.07794774
15EPHB22.05294535
16STK391.95091655
17MAP3K21.66472921
18PTK61.66089633
19PRPF4B1.63567860
20TAOK31.55988451
21STK241.50861345
22MAP2K61.48142488
23TYK21.35440322
24TESK21.33556484
25MET1.31534877
26PIK3CA1.18229139
27DMPK1.18087444
28MAP3K121.11608957
29CDC42BPA1.06118175
30TESK11.04346953
31FGFR31.03643155
32ERN11.03242620
33ERBB21.00956732
34NLK0.99155208
35OXSR10.90004106
36PBK0.87354137
37LATS10.86316069
38PRKCI0.84372042
39TTK0.83837440
40SCYL20.83016665
41MAP3K80.82367196
42STK100.82321468
43WNK40.79621104
44MAP3K110.79517619
45TRIB30.76698271
46PTK20.75756377
47TGFBR20.73270144
48PKN20.72211018
49PRKAA20.70116835
50MYLK0.69073078
51MAPK110.68784612
52MAP4K10.68414938
53ZAP700.68093206
54AKT30.67467864
55SMG10.66218360
56MAP3K70.65360488
57ABL20.65294454
58DDR20.64067168
59TAOK10.63107922
60IRAK10.62489907
61EPHB10.62482659
62FER0.61052849
63PDGFRA0.59893491
64JAK20.59220381
65JAK10.58649937
66MAP3K10.57684105
67PDK30.56228543
68PDK40.56228543
69MAP3K90.55070725
70CDK120.53813239
71EEF2K0.53522618
72MATK0.53023271
73RIPK40.52941126
74DYRK1B0.52125660
75AURKB0.51593755
76RET0.51310835
77KSR20.47727975
78MAP2K10.46877152
79PRKAA10.46068471
80BMX0.45816715
81GRK10.44963673
82TBK10.44777298
83ROCK10.44421614
84EPHA40.43823480
85RPS6KA20.43141737
86PAK30.39114438
87PAK40.37175267
88IKBKE0.36787884
89MAPKAPK20.34821332
90CSNK1E0.34350858
91MAP3K30.33895137
92MUSK0.33832314
93PDPK10.32850907
94FYN0.32733232
95MAP3K60.32434241
96MAPK70.32009290
97RPS6KB20.30753565
98RPS6KC10.30750599
99RPS6KL10.30750599
100CAMK2G0.30530941
101BMPR20.30117060
102CAMK2B0.29976496
103LRRK20.29893685
104TTN0.29825287
105CAMK2D0.29654031
106PDK20.28745581
107JAK30.28331891
108TNIK0.28214222
109BCR0.27834083
110CSNK1A10.27361448
111PAK10.27359111
112CSK0.26783942
113PAK20.25595198
114MAP3K140.25505440
115PRKCA0.24658200
116CDK190.23166088
117PIM20.23165247
118NEK10.22825412
119KIT0.22807641
120PRKCQ0.22650530
121MAPK150.22405929
122KSR10.22161149
123LYN0.21999146
124PRKCD0.21921832
125WNK10.21918969
126RAF10.21565671
127PDK10.21257562
128YES10.20846603
129RPS6KA60.20702464
130STK30.20656000
131GSK3A0.20554187
132AKT20.20421666
133SRC0.20347430
134PRKCZ0.19784593
135PRKACG0.18025879
136STK110.17107378
137TRPM70.15619187
138FGFR40.14833724
139PRKG10.14521332
140ICK0.14431851
141IRAK30.11983039
142PRKCB0.11869873

Predicted pathways (KEGG)

RankGene SetZ-score
1Butirosin and neomycin biosynthesis_Homo sapiens_hsa005245.24438712
2Fat digestion and absorption_Homo sapiens_hsa049755.19033231
3Mineral absorption_Homo sapiens_hsa049783.70629097
4Nitrogen metabolism_Homo sapiens_hsa009103.38838943
5Renin-angiotensin system_Homo sapiens_hsa046143.27103711
6Maturity onset diabetes of the young_Homo sapiens_hsa049502.97383203
7Vitamin digestion and absorption_Homo sapiens_hsa049772.90550407
8Carbohydrate digestion and absorption_Homo sapiens_hsa049732.85957317
9Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.74879801
10Galactose metabolism_Homo sapiens_hsa000522.73939475
11Starch and sucrose metabolism_Homo sapiens_hsa005002.36188843
12Sulfur metabolism_Homo sapiens_hsa009202.28832288
13Fructose and mannose metabolism_Homo sapiens_hsa000512.27088184
14Bile secretion_Homo sapiens_hsa049762.25504354
15Histidine metabolism_Homo sapiens_hsa003402.05226581
16Protein digestion and absorption_Homo sapiens_hsa049741.86176794
17Folate biosynthesis_Homo sapiens_hsa007901.84907142
18Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.83884311
19Caffeine metabolism_Homo sapiens_hsa002321.83606713
20Pentose and glucuronate interconversions_Homo sapiens_hsa000401.76508031
21Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.71051011
22Arginine biosynthesis_Homo sapiens_hsa002201.56279900
23Asthma_Homo sapiens_hsa053101.42392028
24Glutathione metabolism_Homo sapiens_hsa004801.34890075
25Cyanoamino acid metabolism_Homo sapiens_hsa004601.30635310
26Fatty acid degradation_Homo sapiens_hsa000711.30240235
27Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.28212819
28Glycerolipid metabolism_Homo sapiens_hsa005611.27549093
29Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.27464269
30Tryptophan metabolism_Homo sapiens_hsa003801.27268082
31Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.19459694
32Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.18380538
33Arginine and proline metabolism_Homo sapiens_hsa003301.13761878
34Pentose phosphate pathway_Homo sapiens_hsa000301.11570786
35Staphylococcus aureus infection_Homo sapiens_hsa051501.07574069
36Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.07410432
37Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.05875834
38Other glycan degradation_Homo sapiens_hsa005111.04009906
39Tight junction_Homo sapiens_hsa045301.03906348
40Pancreatic secretion_Homo sapiens_hsa049721.03407801
41Thyroid hormone synthesis_Homo sapiens_hsa049181.00218264
42Allograft rejection_Homo sapiens_hsa053300.99415937
43PPAR signaling pathway_Homo sapiens_hsa033200.97389147
44Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.94555135
45Autoimmune thyroid disease_Homo sapiens_hsa053200.93182518
46Pyruvate metabolism_Homo sapiens_hsa006200.92407799
47Graft-versus-host disease_Homo sapiens_hsa053320.89263773
48ABC transporters_Homo sapiens_hsa020100.87931657
49Gastric acid secretion_Homo sapiens_hsa049710.87119207
50Carbon metabolism_Homo sapiens_hsa012000.82648776
51beta-Alanine metabolism_Homo sapiens_hsa004100.82039347
52Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.80674495
53alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.77185276
54Chemical carcinogenesis_Homo sapiens_hsa052040.72165162
55Sulfur relay system_Homo sapiens_hsa041220.69532662
562-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.67326811
57Type I diabetes mellitus_Homo sapiens_hsa049400.65036925
58Lysine degradation_Homo sapiens_hsa003100.62511708
59Sphingolipid metabolism_Homo sapiens_hsa006000.61213242
60Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.59806185
61Phenylalanine metabolism_Homo sapiens_hsa003600.58820790
62Drug metabolism - other enzymes_Homo sapiens_hsa009830.58138185
63Leukocyte transendothelial migration_Homo sapiens_hsa046700.54652137
64Leishmaniasis_Homo sapiens_hsa051400.54146935
65Pertussis_Homo sapiens_hsa051330.53935797
66Intestinal immune network for IgA production_Homo sapiens_hsa046720.53858736
67Biosynthesis of amino acids_Homo sapiens_hsa012300.52551309
68Linoleic acid metabolism_Homo sapiens_hsa005910.51844289
69Steroid biosynthesis_Homo sapiens_hsa001000.48528726
70Glycerophospholipid metabolism_Homo sapiens_hsa005640.48410370
71Type II diabetes mellitus_Homo sapiens_hsa049300.47538809
72Vibrio cholerae infection_Homo sapiens_hsa051100.47469636
73Retinol metabolism_Homo sapiens_hsa008300.47421957
74Salmonella infection_Homo sapiens_hsa051320.47413822
75Salivary secretion_Homo sapiens_hsa049700.47073867
76Viral myocarditis_Homo sapiens_hsa054160.46706136
77Antigen processing and presentation_Homo sapiens_hsa046120.46210211
78Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.45731596
79Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.44538254
80Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.43946941
81Adherens junction_Homo sapiens_hsa045200.43533544
82Tyrosine metabolism_Homo sapiens_hsa003500.43346626
83Adipocytokine signaling pathway_Homo sapiens_hsa049200.43210729
84Thyroid cancer_Homo sapiens_hsa052160.40291759
85Arachidonic acid metabolism_Homo sapiens_hsa005900.39596322
86Insulin resistance_Homo sapiens_hsa049310.39489241
87Bladder cancer_Homo sapiens_hsa052190.36796697
88GnRH signaling pathway_Homo sapiens_hsa049120.35392056
89Butanoate metabolism_Homo sapiens_hsa006500.34642257
90Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.34170111
91Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.32620929
92Insulin secretion_Homo sapiens_hsa049110.32507779
93Hepatitis C_Homo sapiens_hsa051600.32333903
94Toxoplasmosis_Homo sapiens_hsa051450.31379058
95Peroxisome_Homo sapiens_hsa041460.31313772
96Fatty acid metabolism_Homo sapiens_hsa012120.30002762
97Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.29151730
98Selenocompound metabolism_Homo sapiens_hsa004500.28316293
99Renin secretion_Homo sapiens_hsa049240.25343696
100Phosphatidylinositol signaling system_Homo sapiens_hsa040700.25119619
101Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.24844619
102Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.24604825
103African trypanosomiasis_Homo sapiens_hsa051430.22464531
104Ether lipid metabolism_Homo sapiens_hsa005650.21786314
105Amoebiasis_Homo sapiens_hsa051460.21091902
106Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.20542791
107Endometrial cancer_Homo sapiens_hsa052130.19759202
108Complement and coagulation cascades_Homo sapiens_hsa046100.18900790
109Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.18692908
110Metabolic pathways_Homo sapiens_hsa011000.18305915
111Fatty acid biosynthesis_Homo sapiens_hsa000610.16135981
112Vascular smooth muscle contraction_Homo sapiens_hsa042700.14486706
113Hematopoietic cell lineage_Homo sapiens_hsa046400.13499538
114Tuberculosis_Homo sapiens_hsa051520.12942431
115NOD-like receptor signaling pathway_Homo sapiens_hsa046210.12358501
116Chemokine signaling pathway_Homo sapiens_hsa040620.12068551
117Central carbon metabolism in cancer_Homo sapiens_hsa052300.11265484
118Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.11125683
119Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.10752057
120Inositol phosphate metabolism_Homo sapiens_hsa005620.10480701
121Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.09834561
122TNF signaling pathway_Homo sapiens_hsa046680.08188842
123Gap junction_Homo sapiens_hsa045400.07026604
124Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.06905781
125Steroid hormone biosynthesis_Homo sapiens_hsa001400.06676673
126Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.06169845
127Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.05851700
128HIF-1 signaling pathway_Homo sapiens_hsa040660.05744690
129Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.05400264
130Long-term depression_Homo sapiens_hsa047300.05080023
131Influenza A_Homo sapiens_hsa051640.03600490
132VEGF signaling pathway_Homo sapiens_hsa043700.03388596
133Propanoate metabolism_Homo sapiens_hsa006400.01557790

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