ITLN2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)8.63274754
2regulation of guanylate cyclase activity (GO:0031282)7.80260966
3NADH metabolic process (GO:0006734)7.38584492
4lipoprotein transport (GO:0042953)6.96919903
5intestinal absorption (GO:0050892)6.48708347
6fat-soluble vitamin biosynthetic process (GO:0042362)6.41264475
7epoxygenase P450 pathway (GO:0019373)6.26088052
8regulation of bile acid biosynthetic process (GO:0070857)6.06569897
9positive regulation of guanylate cyclase activity (GO:0031284)6.05066491
10fructose metabolic process (GO:0006000)6.00617939
11regulation of cellular extravasation (GO:0002691)5.81087069
12very-low-density lipoprotein particle assembly (GO:0034379)5.43982426
13hormone catabolic process (GO:0042447)5.41775127
14regulation of systemic arterial blood pressure by hormone (GO:0001990)5.37258995
15regulation of systemic arterial blood pressure mediated by a chemical signal (GO:0003044)5.37258995
16endocrine process (GO:0050886)5.37258995
17plasma lipoprotein particle assembly (GO:0034377)5.21753506
18diacylglycerol metabolic process (GO:0046339)5.12960510
19antibacterial humoral response (GO:0019731)5.00689242
20virion attachment to host cell (GO:0019062)4.96780628
21adhesion of symbiont to host cell (GO:0044650)4.96780628
22regulation of systemic arterial blood pressure (GO:0003073)4.93383386
23antimicrobial humoral response (GO:0019730)4.82221474
24drug metabolic process (GO:0017144)4.76686326
25regulation of cGMP biosynthetic process (GO:0030826)4.75611924
26protein-lipid complex assembly (GO:0065005)4.69893544
27regulation of triglyceride catabolic process (GO:0010896)4.68270319
28receptor guanylyl cyclase signaling pathway (GO:0007168)4.61320681
29phospholipid efflux (GO:0033700)4.52135685
30peptide catabolic process (GO:0043171)4.51156235
31urea cycle (GO:0000050)4.50817909
32peptide hormone processing (GO:0016486)4.46945323
33positive regulation of pseudopodium assembly (GO:0031274)4.44797302
34positive regulation of glycoprotein biosynthetic process (GO:0010560)4.42713421
35regulation of cholesterol esterification (GO:0010872)4.35502427
36urea metabolic process (GO:0019627)4.26868876
37bile acid and bile salt transport (GO:0015721)4.23962174
38digestion (GO:0007586)4.23737810
39cellular response to nitric oxide (GO:0071732)4.22844421
40renal system process involved in regulation of blood volume (GO:0001977)4.19913180
41adhesion of symbiont to host (GO:0044406)4.16204041
42glucuronate metabolic process (GO:0019585)4.10918828
43uronic acid metabolic process (GO:0006063)4.10918828
44homocysteine metabolic process (GO:0050667)4.09320991
45cellular glucuronidation (GO:0052695)4.07224215
46positive regulation of glycoprotein metabolic process (GO:1903020)4.02843795
47vitamin transmembrane transport (GO:0035461)4.02032087
48glycolipid catabolic process (GO:0019377)3.99877397
49regulation of vitamin metabolic process (GO:0030656)3.98762411
50regulation of pseudopodium assembly (GO:0031272)3.97857598
51regulation of cGMP metabolic process (GO:0030823)3.94810608
52lipoprotein metabolic process (GO:0042157)3.93624991
53nitrogen cycle metabolic process (GO:0071941)3.92559210
54glycosphingolipid catabolic process (GO:0046479)3.91751855
55vitamin A metabolic process (GO:0006776)3.91652610
56response to nitric oxide (GO:0071731)3.87409596
57vitamin transport (GO:0051180)3.74585528
58drinking behavior (GO:0042756)3.72189916
59alkaloid metabolic process (GO:0009820)3.60486760
60maintenance of gastrointestinal epithelium (GO:0030277)3.60482106
61glutamine family amino acid biosynthetic process (GO:0009084)3.57889321
62fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.56720368
63high-density lipoprotein particle remodeling (GO:0034375)3.54708787
64fat-soluble vitamin metabolic process (GO:0006775)3.53959464
65positive regulation of cGMP biosynthetic process (GO:0030828)3.51623687
66plasma lipoprotein particle organization (GO:0071827)3.47483584
67transcytosis (GO:0045056)3.47474455
68cellular response to reactive nitrogen species (GO:1902170)3.47086515
69plasma lipoprotein particle remodeling (GO:0034369)3.45214694
70protein-lipid complex remodeling (GO:0034368)3.45214694
71macromolecular complex remodeling (GO:0034367)3.45214694
72nucleoside diphosphate biosynthetic process (GO:0009133)3.42436723
73arginine metabolic process (GO:0006525)3.41351865
74positive regulation of lipoprotein lipase activity (GO:0051006)3.39035373
75positive regulation of triglyceride lipase activity (GO:0061365)3.39035373
76L-ascorbic acid metabolic process (GO:0019852)3.37232596
77cobalamin metabolic process (GO:0009235)3.35822813
78bile acid metabolic process (GO:0008206)3.34749907
79drug catabolic process (GO:0042737)3.34662553
80vitamin biosynthetic process (GO:0009110)3.34614479
81flavonoid metabolic process (GO:0009812)3.33644134
82protein-lipid complex subunit organization (GO:0071825)3.29758145
83phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)3.29405403
84midgut development (GO:0007494)3.29106954
85triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.26385967
86cGMP-mediated signaling (GO:0019934)3.24493124
87antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.23742367
88transepithelial transport (GO:0070633)3.21426376
89cGMP biosynthetic process (GO:0006182)3.19192578
90glycosylceramide metabolic process (GO:0006677)3.15964065
91ceramide catabolic process (GO:0046514)3.15932594
92negative regulation of epidermal cell differentiation (GO:0045605)3.14463844
93digestive system process (GO:0022600)3.14288637
94antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.08239387
95reverse cholesterol transport (GO:0043691)3.05806151
96exogenous drug catabolic process (GO:0042738)3.05603153
97low-density lipoprotein particle remodeling (GO:0034374)3.05573901
98cholesterol homeostasis (GO:0042632)3.05418908
99leukotriene metabolic process (GO:0006691)3.05297232
100angiotensin maturation (GO:0002003)11.4541494

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1CDX2_20551321_ChIP-Seq_CACO-2_Human5.59411910
2ESR1_17901129_ChIP-ChIP_LIVER_Mouse4.55419452
3IRF1_21803131_ChIP-Seq_MONOCYTES_Human4.20724322
4BP1_19119308_ChIP-ChIP_Hs578T_Human3.86865687
5HNF4A_19761587_ChIP-ChIP_CACO-2_Human3.78229969
6GATA4_25053715_ChIP-Seq_YYC3_Human3.23821728
7SOX2_27498859_Chip-Seq_STOMACH_Mouse3.11697929
8PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.79615885
9CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human2.76158311
10GATA6_25053715_ChIP-Seq_YYC3_Human2.74019765
11RXR_22158963_ChIP-Seq_LIVER_Mouse2.69449150
12IRF8_22096565_ChIP-ChIP_GC-B_Human2.66956262
13EGR1_23403033_ChIP-Seq_LIVER_Mouse2.56583614
14PPARA_22158963_ChIP-Seq_LIVER_Mouse2.55559391
15LXR_22158963_ChIP-Seq_LIVER_Mouse2.50327434
16GATA1_22025678_ChIP-Seq_K562_Human2.35883167
17SOX2_20726797_ChIP-Seq_SW620_Human2.30815405
18CDX2_19796622_ChIP-Seq_MESCs_Mouse2.21234425
19NR0B1_18358816_ChIP-ChIP_MESCs_Mouse2.19317387
20RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.97016190
21STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.96980632
22FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.90399763
23BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.85599785
24MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.78945684
25FOXO3_23340844_ChIP-Seq_DLD1_Human1.74846483
26TRIM28_21343339_ChIP-Seq_HEK293_Human1.74320672
27PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.70561884
28AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.58956266
29TCF4_18268006_ChIP-ChIP_LS174T_Human1.56054557
30CLOCK_20551151_ChIP-Seq_293T_Human1.54692068
31PPAR_26484153_Chip-Seq_NCI-H1993_Human1.53091742
32FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.49277341
33HNF4A_19822575_ChIP-Seq_HepG2_Human1.44469846
34BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.43402073
35* LXR_22292898_ChIP-Seq_THP-1_Human1.42939992
36TCF3_18692474_ChIP-Seq_MEFs_Mouse1.34102918
37THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.33309000
38IRF8_21731497_ChIP-ChIP_J774_Mouse1.31314025
39KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.29900938
40ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.28814070
41CDX2_22108803_ChIP-Seq_LS180_Human1.27038551
42AR_21909140_ChIP-Seq_LNCAP_Human1.26126255
43FOXA1_25552417_ChIP-Seq_VCAP_Human1.26061358
44TP63_17297297_ChIP-ChIP_HaCaT_Human1.25573004
45PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.22867981
46SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.20814520
47RACK7_27058665_Chip-Seq_MCF-7_Human1.17389610
48EGR1_19032775_ChIP-ChIP_M12_Human1.15422170
49KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.14370276
50* SA1_27219007_Chip-Seq_Bcells_Human1.14367705
51NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.13818012
52* ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.12155418
53CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.09942480
54NANOG_20526341_ChIP-Seq_ESCs_Human1.09914061
55SRY_22984422_ChIP-ChIP_TESTIS_Rat1.07751601
56RXR_22108803_ChIP-Seq_LS180_Human1.07718390
57TET1_21451524_ChIP-Seq_MESCs_Mouse1.07537612
58BCOR_27268052_Chip-Seq_Bcells_Human1.07276441
59JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse1.06770850
60FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.05773103
61* GATA2_19941826_ChIP-Seq_K562_Human1.05606426
62TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.05407888
63FOXA2_19822575_ChIP-Seq_HepG2_Human1.05389859
64GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.04113997
65STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.01705988
66BCL6_27268052_Chip-Seq_Bcells_Human1.01620671
67KLF5_25053715_ChIP-Seq_YYC3_Human1.00964089
68CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.99299269
69SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.99085847
70* CTCF_27219007_Chip-Seq_Bcells_Human0.96897474
71PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.96748460
72NANOG_18692474_ChIP-Seq_MEFs_Mouse0.96143986
73OCT4_18692474_ChIP-Seq_MEFs_Mouse0.93880084
74GATA2_22383799_ChIP-Seq_G1ME_Mouse0.93266886
75E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.93198205
76NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.92670118
77SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.91961130
78GATA1_19941826_ChIP-Seq_K562_Human0.91191604
79KAP1_22055183_ChIP-Seq_ESCs_Mouse0.88527026
80CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.86924150
81RAD21_21589869_ChIP-Seq_MESCs_Mouse0.86884800
82CEBPB_22108803_ChIP-Seq_LS180_Human0.86656904
83ESR1_21235772_ChIP-Seq_MCF-7_Human0.85883754
84FOXA1_21572438_ChIP-Seq_LNCaP_Human0.85631214
85CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.85401932
86VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.84540178
87* P63_26484246_Chip-Seq_KERATINOCYTES_Human0.83706890
88EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.83047619
89SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.82810823
90TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.82209787
91RARG_19884340_ChIP-ChIP_MEFs_Mouse0.80685257
92PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.80111346
93SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.80092938
94EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.80003412
95GATA1_22383799_ChIP-Seq_G1ME_Mouse0.79603321
96FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.79480927
97VDR_24787735_ChIP-Seq_THP-1_Human0.79376504
98TCF7L2_21901280_ChIP-Seq_H4IIE_Rat0.79283063
99* GATA3_24758297_ChIP-Seq_MCF-7_Human0.79141694
100AUTS2_25519132_ChIP-Seq_293T-REX_Human0.78116980

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005360_urolithiasis9.01124947
2MP0001666_abnormal_nutrient_absorption4.96252607
3MP0005085_abnormal_gallbladder_physiolo4.59621167
4MP0003183_abnormal_peptide_metabolism4.29909615
5MP0009840_abnormal_foam_cell4.05657486
6MP0009379_abnormal_foot_pigmentation3.98384764
7MP0004019_abnormal_vitamin_homeostasis3.87812973
8MP0002139_abnormal_hepatobiliary_system3.54774420
9MP0005365_abnormal_bile_salt3.52543972
10MP0004264_abnormal_extraembryonic_tissu3.41147521
11MP0004147_increased_porphyrin_level3.33089391
12MP0010155_abnormal_intestine_physiology2.92500629
13MP0010234_abnormal_vibrissa_follicle2.66760846
14MP0010329_abnormal_lipoprotein_level2.18096531
15MP0005409_darkened_coat_color2.07523657
16MP0001664_abnormal_digestion1.97340370
17MP0005332_abnormal_amino_acid1.92796030
18MP0000490_abnormal_crypts_of1.90261407
19MP0003866_abnormal_defecation1.86347128
20MP0009643_abnormal_urine_homeostasis1.81370129
21MP0010352_gastrointestinal_tract_polyps1.78616421
22MP0003868_abnormal_feces_composition1.69478432
23MP0001188_hyperpigmentation1.67361539
24MP0001764_abnormal_homeostasis1.61875804
25MP0005166_decreased_susceptibility_to1.61609617
26MP0003806_abnormal_nucleotide_metabolis1.56031513
27MP0000477_abnormal_intestine_morphology1.51484872
28MP0003718_maternal_effect1.47254296
29MP0000538_abnormal_urinary_bladder1.46505383
30MP0000678_abnormal_parathyroid_gland1.40799437
31MP0003252_abnormal_bile_duct1.34562654
32MP0001873_stomach_inflammation1.34424901
33MP0004782_abnormal_surfactant_physiolog1.32792678
34MP0002876_abnormal_thyroid_physiology1.32700161
35MP0005670_abnormal_white_adipose1.31483285
36MP0000462_abnormal_digestive_system1.30444641
37MP0001765_abnormal_ion_homeostasis1.28473182
38MP0004858_abnormal_nervous_system1.26603721
39MP0005636_abnormal_mineral_homeostasis1.25532036
40MP0002822_catalepsy1.23765034
41MP0001663_abnormal_digestive_system1.21072229
42MP0004270_analgesia1.19092349
43MP0002136_abnormal_kidney_physiology1.17906465
44MP0003191_abnormal_cellular_cholesterol1.13856005
45MP0002118_abnormal_lipid_homeostasis1.11262748
46MP0003879_abnormal_hair_cell1.08153173
47MP0005381_digestive/alimentary_phenotyp1.03741660
48MP0001501_abnormal_sleep_pattern0.99618782
49MP0005448_abnormal_energy_balance0.96587488
50MP0005584_abnormal_enzyme/coenzyme_acti0.94933223
51MP0000537_abnormal_urethra_morphology0.94501861
52MP0001756_abnormal_urination0.93332229
53MP0000609_abnormal_liver_physiology0.90676309
54MP0005535_abnormal_body_temperature0.88803771
55MP0001845_abnormal_inflammatory_respons0.87860103
56MP0002796_impaired_skin_barrier0.84702548
57MP0001485_abnormal_pinna_reflex0.82085113
58MP0002098_abnormal_vibrissa_morphology0.81392529
59MP0002138_abnormal_hepatobiliary_system0.79414025
60MP0000230_abnormal_systemic_arterial0.78264204
61MP0005451_abnormal_body_composition0.74772683
62MP0000465_gastrointestinal_hemorrhage0.73773844
63MP0002971_abnormal_brown_adipose0.73565910
64MP0000604_amyloidosis0.71537294
65MP0008004_abnormal_stomach_pH0.70320901
66MP0008469_abnormal_protein_level0.69717329
67MP0005319_abnormal_enzyme/_coenzyme0.69705035
68MP0009115_abnormal_fat_cell0.69255998
69MP0003724_increased_susceptibility_to0.67495986
70MP0009642_abnormal_blood_homeostasis0.66559214
71MP0002396_abnormal_hematopoietic_system0.65983417
72MP0009785_altered_susceptibility_to0.64874828
73MP0009764_decreased_sensitivity_to0.64099943
74MP0004043_abnormal_pH_regulation0.60705709
75MP0005174_abnormal_tail_pigmentation0.58757878
76MP0000249_abnormal_blood_vessel0.56976614
77MP0005025_abnormal_response_to0.56961072
78MP0001881_abnormal_mammary_gland0.56339780
79MP0001835_abnormal_antigen_presentation0.55507012
80MP0002166_altered_tumor_susceptibility0.55268846
81MP0008260_abnormal_autophagy0.54198554
82MP0009333_abnormal_splenocyte_physiolog0.53824706
83MP0008872_abnormal_physiological_respon0.53641529
84MP0006082_CNS_inflammation0.53487599
85MP0003300_gastrointestinal_ulcer0.53069654
86MP0005501_abnormal_skin_physiology0.52980044
87MP0003638_abnormal_response/metabolism_0.52586053
88MP0003329_amyloid_beta_deposits0.50426557
89MP0000516_abnormal_urinary_system0.50246848
90MP0005367_renal/urinary_system_phenotyp0.50246848
91MP0001790_abnormal_immune_system0.49538935
92MP0005387_immune_system_phenotype0.49538935
93MP0005666_abnormal_adipose_tissue0.49139106
94MP0006138_congestive_heart_failure0.45725963
95MP0001849_ear_inflammation0.45135665
96MP0005334_abnormal_fat_pad0.44577076
97MP0003953_abnormal_hormone_level0.43072625
98MP0002078_abnormal_glucose_homeostasis0.42630518
99MP0002896_abnormal_bone_mineralization0.42555601
100MP0002254_reproductive_system_inflammat0.42463995

Predicted human phenotypes

RankGene SetZ-score
1Malnutrition (HP:0004395)7.60386012
2Hydroxyprolinuria (HP:0003080)7.37855074
3Abnormality of proline metabolism (HP:0010907)7.37855074
4Hypobetalipoproteinemia (HP:0003563)6.02391360
5Abnormality of the vitamin B12 metabolism (HP:0004341)5.66553539
6Chronic diarrhea (HP:0002028)5.40237621
7Abnormality of vitamin B metabolism (HP:0004340)5.31603603
8Fat malabsorption (HP:0002630)4.83327493
9Widely patent fontanelles and sutures (HP:0004492)4.81723812
10Ileus (HP:0002595)4.70215602
11Acanthocytosis (HP:0001927)4.69823394
12Confusion (HP:0001289)4.68770618
13Systemic lupus erythematosus (HP:0002725)4.33095084
14Hyperglycinuria (HP:0003108)4.32548464
15Abnormality of vitamin metabolism (HP:0100508)4.19666000
16Nausea (HP:0002018)4.18271136
17Pigmentary retinal degeneration (HP:0001146)3.87020927
18Abnormality of urine glucose concentration (HP:0011016)3.83488472
19Glycosuria (HP:0003076)3.83488472
20Abnormality of glycine metabolism (HP:0010895)3.72097643
21Abnormality of serine family amino acid metabolism (HP:0010894)3.72097643
22Proximal tubulopathy (HP:0000114)3.66834856
23Wide cranial sutures (HP:0010537)3.58506916
24Nephrolithiasis (HP:0000787)3.36083396
25Thin bony cortex (HP:0002753)3.33462444
26Steatorrhea (HP:0002570)3.27821044
27Hypolipoproteinemia (HP:0010981)3.23781159
28Megaloblastic anemia (HP:0001889)3.22479772
29Congenital sensorineural hearing impairment (HP:0008527)3.18736536
30Xanthomatosis (HP:0000991)3.18182637
31Decreased circulating renin level (HP:0003351)3.08740440
32Increased purine levels (HP:0004368)3.07307135
33Hyperuricemia (HP:0002149)3.07307135
34Posterior subcapsular cataract (HP:0007787)3.05522077
35Potter facies (HP:0002009)3.04603909
36Facial shape deformation (HP:0011334)3.04603909
37Abnormality of monocarboxylic acid metabolism (HP:0010996)3.03841481
38Abnormality of aspartate family amino acid metabolism (HP:0010899)2.94425626
39Hypophosphatemia (HP:0002148)2.91207637
40Alkalosis (HP:0001948)2.86685116
41Abdominal distention (HP:0003270)2.80107555
42Metabolic alkalosis (HP:0200114)2.78122786
43Hyperammonemia (HP:0001987)2.77923491
44Abnormality of purine metabolism (HP:0004352)2.65507356
45Hyperactive renin-angiotensin system (HP:0000841)2.63705921
46Abnormal urine phosphate concentration (HP:0012599)2.62896914
47Abnormality of small intestinal villus morphology (HP:0011472)2.58853667
48Villous atrophy (HP:0011473)2.58853667
49Hyperphosphaturia (HP:0003109)2.50921634
50Abnormality of nucleobase metabolism (HP:0010932)2.49210400
51Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.47407638
52Enlarged epiphyses (HP:0010580)2.46075463
53Delayed epiphyseal ossification (HP:0002663)2.43784692
54Eczematoid dermatitis (HP:0000976)2.40977252
55Hyperparathyroidism (HP:0000843)2.40414982
56Hypotension (HP:0002615)2.34945999
57Right ventricular cardiomyopathy (HP:0011663)2.32456282
58Abnormality of renin-angiotensin system (HP:0000847)2.30990737
59Epidermoid cyst (HP:0200040)2.27602428
60Abnormality of the costochondral junction (HP:0000919)2.25659443
61Metabolic acidosis (HP:0001942)2.24605796
62Subcapsular cataract (HP:0000523)2.22323024
63Glomerulonephritis (HP:0000099)2.21977025
64Abnormality of magnesium homeostasis (HP:0004921)2.21907785
65Gout (HP:0001997)2.21103208
66Cerebral palsy (HP:0100021)2.20576326
67Abnormal glucose tolerance (HP:0001952)2.19421224
68Focal segmental glomerulosclerosis (HP:0000097)2.18243838
69Abnormality of sulfur amino acid metabolism (HP:0004339)2.18034407
70Abnormality of pyrimidine metabolism (HP:0004353)2.13653403
71Hemorrhage of the eye (HP:0011885)2.09270568
72Abnormality of dicarboxylic acid metabolism (HP:0010995)2.09024300
73Dicarboxylic aciduria (HP:0003215)2.09024300
74Hyperphosphatemia (HP:0002905)2.08487193
75Renal tubular acidosis (HP:0001947)2.07869909
76Pancreatitis (HP:0001733)2.06914847
77Abnormality of glutamine family amino acid metabolism (HP:0010902)10.5274536
78Irritability (HP:0000737)1.97105407
79Poikilocytosis (HP:0004447)1.95506978
80Abnormality of complement system (HP:0005339)1.94490943
81Symptomatic seizures (HP:0011145)1.93751163
82Intrahepatic cholestasis (HP:0001406)1.92218116
83Nephritis (HP:0000123)1.91434744
84Gingivitis (HP:0000230)1.90047320
85Abnormality of alkaline phosphatase activity (HP:0004379)1.87782884
86Protuberant abdomen (HP:0001538)1.87304967
87Abnormal enzyme/coenzyme activity (HP:0012379)1.86352759
88Gastrointestinal dysmotility (HP:0002579)1.86132269
89Complement deficiency (HP:0004431)1.85715916
90Lethargy (HP:0001254)1.84076264
91Renal tubular dysfunction (HP:0000124)1.81546201
92Abnormal biliary tract morphology (HP:0012440)1.71963947
93Hypoalbuminemia (HP:0003073)1.71709061
94Abnormal albumin level (HP:0012116)1.71709061
95Macrocytic anemia (HP:0001972)1.66789836
96Paresthesia (HP:0003401)1.66052056
97Multiple lipomas (HP:0001012)1.65926652
98Amyloidosis (HP:0011034)1.65212200
99White forelock (HP:0002211)1.64775283
100Patchy hypopigmentation of hair (HP:0011365)1.63428350

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ACVR1B8.71350287
2ERN14.19174148
3MST1R3.91079250
4PRKG23.79063411
5RIPK13.36734430
6MAP3K103.23255869
7PDK22.67910012
8STK392.49183579
9EPHA22.46056421
10OXSR12.25818698
11TNIK2.21264021
12TESK22.18763821
13FGFR42.11898087
14MST41.91903176
15MAP3K121.89720180
16TYK21.66147561
17PTK61.66059873
18EPHB21.55996041
19MET1.49978367
20EPHA31.49237846
21MAP3K21.46797843
22AKT31.44771885
23GRK61.36343404
24MAP4K11.33226497
25MATK1.23787806
26EPHB11.23590915
27CASK1.23248131
28NLK1.22556788
29DDR21.20390731
30MYLK1.19567734
31MAP3K11.10770396
32EPHA41.07699208
33STK241.05895931
34MAP2K20.98028106
35FGFR30.95171964
36ERBB20.92617673
37LMTK20.87038157
38RIPK40.85838458
39PRPF4B0.84831932
40CDK190.80552581
41PDPK10.79965658
42PBK0.76429553
43CDC42BPA0.76397701
44MAP3K110.72548162
45PRKACG0.70883433
46FER0.67801870
47GRK10.64984565
48TESK10.63523500
49PRKCA0.61959075
50PIK3CA0.60176122
51PIM10.59847340
52PAK40.58530028
53PRKAA20.57343254
54PRKCZ0.56150746
55MAP2K60.55313784
56MAPK110.54277264
57PDK10.53159644
58KDR0.48218443
59IRAK10.47355364
60TAOK10.44825109
61DYRK1B0.43920478
62JAK10.43806432
63SRC0.42646505
64CAMK2D0.40398671
65BMX0.40263138
66PDGFRA0.37632379
67ABL20.37546316
68PRKCD0.37081623
69YES10.36101860
70CSK0.35720877
71IKBKE0.35280070
72FYN0.35117597
73MELK0.33740767
74TBK10.33729234
75PTK20.32228468
76CAMK2G0.31061626
77JAK20.31039421
78CSF1R0.29374029
79CDK60.28556178
80MAP3K80.28363261
81RET0.27634676
82CAMK2B0.27190631
83KSR20.24430574
84ITK0.24297813
85MAP3K30.22961125
86FGR0.22851034
87TEC0.22417163
88PRKCQ0.21460646
89NEK60.20949310
90DMPK0.20802425
91BTK0.20411068
92JAK30.20297550
93SMG10.20263262
94ZAP700.20074870
95TGFBR20.19735751
96PRKCI0.19261141
97IGF1R0.19231251
98PIK3CG0.18654876
99LRRK20.18568982
100DAPK20.18184048

Predicted pathways (KEGG)

RankGene SetZ-score
1Cyanoamino acid metabolism_Homo sapiens_hsa004605.22242141
2Vitamin digestion and absorption_Homo sapiens_hsa049774.89169106
3Fat digestion and absorption_Homo sapiens_hsa049754.67539978
4Renin-angiotensin system_Homo sapiens_hsa046144.19806574
5Mineral absorption_Homo sapiens_hsa049782.66375986
6Protein digestion and absorption_Homo sapiens_hsa049742.57941873
7Arginine biosynthesis_Homo sapiens_hsa002202.40900884
8Histidine metabolism_Homo sapiens_hsa003402.35520778
9Caffeine metabolism_Homo sapiens_hsa002322.31260355
10Starch and sucrose metabolism_Homo sapiens_hsa005002.28021113
11Fructose and mannose metabolism_Homo sapiens_hsa000512.12990314
12Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.12862489
13Pentose and glucuronate interconversions_Homo sapiens_hsa000402.08422819
14Linoleic acid metabolism_Homo sapiens_hsa005912.03728455
15Galactose metabolism_Homo sapiens_hsa000521.99739030
16alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.98981799
17Chemical carcinogenesis_Homo sapiens_hsa052041.90316125
18Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.88931552
19Carbohydrate digestion and absorption_Homo sapiens_hsa049731.88587987
20Retinol metabolism_Homo sapiens_hsa008301.76901814
21PPAR signaling pathway_Homo sapiens_hsa033201.74404916
22Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.70884919
23Drug metabolism - other enzymes_Homo sapiens_hsa009831.70590979
24Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.66069200
25Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.65511520
26Sulfur metabolism_Homo sapiens_hsa009201.50902190
27Arachidonic acid metabolism_Homo sapiens_hsa005901.48932273
28Arginine and proline metabolism_Homo sapiens_hsa003301.45977433
29Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.45119335
30Bile secretion_Homo sapiens_hsa049761.42678855
31Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.40788943
32Maturity onset diabetes of the young_Homo sapiens_hsa049501.33527914
33Glycerolipid metabolism_Homo sapiens_hsa005611.33308669
34Asthma_Homo sapiens_hsa053101.28269002
35Steroid hormone biosynthesis_Homo sapiens_hsa001401.27993521
362-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.22832695
37Fatty acid degradation_Homo sapiens_hsa000711.20663312
38Tryptophan metabolism_Homo sapiens_hsa003801.19233593
39Ether lipid metabolism_Homo sapiens_hsa005651.15684299
40Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.14795147
41Intestinal immune network for IgA production_Homo sapiens_hsa046721.11485263
42Glutathione metabolism_Homo sapiens_hsa004801.06032332
43Allograft rejection_Homo sapiens_hsa053300.87609023
44Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.87496524
45Phenylalanine metabolism_Homo sapiens_hsa003600.87380463
46Autoimmune thyroid disease_Homo sapiens_hsa053200.82102595
47Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.77815109
48Graft-versus-host disease_Homo sapiens_hsa053320.77211387
49Staphylococcus aureus infection_Homo sapiens_hsa051500.73241846
50Sphingolipid metabolism_Homo sapiens_hsa006000.70015522
51Glycerophospholipid metabolism_Homo sapiens_hsa005640.67575531
52Pancreatic secretion_Homo sapiens_hsa049720.66092236
53Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.63726568
54Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.60356549
55Type I diabetes mellitus_Homo sapiens_hsa049400.58634162
56Folate biosynthesis_Homo sapiens_hsa007900.57941890
57Peroxisome_Homo sapiens_hsa041460.56544108
58Fatty acid metabolism_Homo sapiens_hsa012120.53105567
59Pentose phosphate pathway_Homo sapiens_hsa000300.50092288
60Primary bile acid biosynthesis_Homo sapiens_hsa001200.42715299
61Other glycan degradation_Homo sapiens_hsa005110.39346218
62Antigen processing and presentation_Homo sapiens_hsa046120.38725535
63Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.37812582
64Tyrosine metabolism_Homo sapiens_hsa003500.35773528
65Renin secretion_Homo sapiens_hsa049240.32768200
66Carbon metabolism_Homo sapiens_hsa012000.31130243
67Biosynthesis of amino acids_Homo sapiens_hsa012300.30703782
68Pyruvate metabolism_Homo sapiens_hsa006200.26157934
69Thyroid hormone synthesis_Homo sapiens_hsa049180.25602895
70Fatty acid biosynthesis_Homo sapiens_hsa000610.25496035
71Fatty acid elongation_Homo sapiens_hsa000620.25086720
72Metabolic pathways_Homo sapiens_hsa011000.24889669
73Insulin resistance_Homo sapiens_hsa049310.23913389
74Leishmaniasis_Homo sapiens_hsa051400.22744362
75Tight junction_Homo sapiens_hsa045300.20385592
76Sulfur relay system_Homo sapiens_hsa041220.18470685
77ABC transporters_Homo sapiens_hsa020100.17283231
78Viral myocarditis_Homo sapiens_hsa054160.17089113
79Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.16539015
80Cocaine addiction_Homo sapiens_hsa050300.15104886
81Adipocytokine signaling pathway_Homo sapiens_hsa049200.14691907
82Propanoate metabolism_Homo sapiens_hsa006400.14682427
83Hepatitis C_Homo sapiens_hsa051600.14103140
84Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.13901450
85Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.13805391
86Glucagon signaling pathway_Homo sapiens_hsa049220.13211213
87Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.13192385
88Pertussis_Homo sapiens_hsa051330.12583365
89Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.12083607
90Butanoate metabolism_Homo sapiens_hsa006500.11042710
91Leukocyte transendothelial migration_Homo sapiens_hsa046700.10276449
92African trypanosomiasis_Homo sapiens_hsa051430.09824177
93Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.08575081
94Hematopoietic cell lineage_Homo sapiens_hsa046400.06033081
95Toxoplasmosis_Homo sapiens_hsa051450.02693134
96Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.00872701
97beta-Alanine metabolism_Homo sapiens_hsa004100.00595896
98Amphetamine addiction_Homo sapiens_hsa050310.00249858
99Insulin secretion_Homo sapiens_hsa04911-0.0045263
100Serotonergic synapse_Homo sapiens_hsa04726-0.0013374

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