ITM2A

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a type II membrane protein that belongs to the ITM2 family. Studies in mouse suggest that it may be involved in osteo- and chondrogenic differentiation. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1heme transport (GO:0015886)8.33450576
2lymph vessel development (GO:0001945)8.02870257
3endothelium development (GO:0003158)6.80541347
4diacylglycerol metabolic process (GO:0046339)6.80457589
5negative regulation of inclusion body assembly (GO:0090084)6.72676736
6embryonic process involved in female pregnancy (GO:0060136)5.96225517
7iron coordination entity transport (GO:1901678)5.95024510
8phospholipid homeostasis (GO:0055091)5.67015833
9radial glial cell differentiation (GO:0060019)5.46633748
10response to folic acid (GO:0051593)5.23654151
11vascular endothelial growth factor signaling pathway (GO:0038084)5.13020333
12triglyceride-rich lipoprotein particle remodeling (GO:0034370)4.95318793
13angiogenesis involved in wound healing (GO:0060055)4.87818190
14positive regulation of vasculogenesis (GO:2001214)4.86341293
15endothelial cell proliferation (GO:0001935)4.77196713
16endoderm formation (GO:0001706)4.76424992
17mRNA transcription (GO:0009299)4.74171547
18negative regulation of macrophage derived foam cell differentiation (GO:0010745)4.70719639
19cytidine deamination (GO:0009972)4.68751688
20cytidine metabolic process (GO:0046087)4.68751688
21cytidine catabolic process (GO:0006216)4.68751688
22negative regulation of endothelial cell apoptotic process (GO:2000352)4.66307368
23transcytosis (GO:0045056)4.62148207
24negative regulation of actin filament bundle assembly (GO:0032232)4.52432596
25peptidyl-tyrosine autophosphorylation (GO:0038083)4.42354610
26embryonic heart tube development (GO:0035050)4.26505000
27sequestering of actin monomers (GO:0042989)4.26038696
28low-density lipoprotein particle remodeling (GO:0034374)4.24920866
29leukocyte tethering or rolling (GO:0050901)4.20993760
30sodium-independent organic anion transport (GO:0043252)4.20319823
31limb bud formation (GO:0060174)4.18445920
32negative regulation of protein localization to cell surface (GO:2000009)4.15302798
33patterning of blood vessels (GO:0001569)4.12973142
34establishment of endothelial barrier (GO:0061028)4.12246937
35endothelial cell differentiation (GO:0045446)4.05938036
36negative regulation of vascular permeability (GO:0043116)4.05383974
37regulation of vasculogenesis (GO:2001212)3.97483560
38retina vasculature morphogenesis in camera-type eye (GO:0061299)3.95154632
39definitive hemopoiesis (GO:0060216)3.94048362
40establishment of protein localization to mitochondrial membrane (GO:0090151)3.93028578
41leukocyte migration involved in inflammatory response (GO:0002523)3.89411168
42developmental pigmentation (GO:0048066)3.86757678
43negative regulation of blood vessel endothelial cell migration (GO:0043537)3.85011490
44negative regulation of cell fate specification (GO:0009996)3.83309200
45monocyte differentiation (GO:0030224)3.80806679
46regulation of vascular endothelial growth factor receptor signaling pathway (GO:0030947)3.75071702
47pyrimidine ribonucleoside catabolic process (GO:0046133)3.74605416
48drug transmembrane transport (GO:0006855)3.73658491
49sprouting angiogenesis (GO:0002040)3.72240563
50cell proliferation involved in kidney development (GO:0072111)3.70310938
51urate metabolic process (GO:0046415)3.67876246
52positive regulation of B cell differentiation (GO:0045579)3.62660220
53embryonic skeletal joint morphogenesis (GO:0060272)3.60622981
54cAMP catabolic process (GO:0006198)3.59501157
55vascular endothelial growth factor receptor signaling pathway (GO:0048010)3.58374172
56chondrocyte development (GO:0002063)3.58072357
57exocrine pancreas development (GO:0031017)3.56020660
58endocardial cushion morphogenesis (GO:0003203)3.55788104
59regulation of endothelial cell differentiation (GO:0045601)3.53514632
60positive regulation of epithelial to mesenchymal transition (GO:0010718)3.50106567
61positive thymic T cell selection (GO:0045059)3.49612409
62glycine transport (GO:0015816)3.48803523
63positive T cell selection (GO:0043368)3.47014735
64auditory behavior (GO:0031223)3.46759431
65cellular response to vascular endothelial growth factor stimulus (GO:0035924)3.45769196
66positive regulation of Rap GTPase activity (GO:0032854)3.45468420
67collagen fibril organization (GO:0030199)3.44387030
68glycerol metabolic process (GO:0006071)3.43776344
69positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.42947225
70cell aggregation (GO:0098743)3.36870646
71cartilage condensation (GO:0001502)3.36870646
72regulation of heart morphogenesis (GO:2000826)3.36554045
73cAMP biosynthetic process (GO:0006171)3.36227033
74reverse cholesterol transport (GO:0043691)3.34931477
75heart trabecula morphogenesis (GO:0061384)3.33836874
76ovulation from ovarian follicle (GO:0001542)3.33401967
77mesenchyme morphogenesis (GO:0072132)3.30820799
78notochord development (GO:0030903)3.30146755
79high-density lipoprotein particle remodeling (GO:0034375)3.29773228
80lymphangiogenesis (GO:0001946)3.29355736
81DNA deamination (GO:0045006)3.25459709
82regulation of establishment or maintenance of cell polarity (GO:0032878)3.25339550
83T cell migration (GO:0072678)3.24805620
84cofactor transport (GO:0051181)3.23996074
85cell proliferation involved in metanephros development (GO:0072203)3.22921537
86endothelial tube morphogenesis (GO:0061154)3.22159454
87morphogenesis of an endothelium (GO:0003159)3.22159454
88endothelial cell morphogenesis (GO:0001886)3.20589299
89cAMP metabolic process (GO:0046058)3.20442165
90regulation of inclusion body assembly (GO:0090083)3.19096673
91histamine secretion (GO:0001821)3.17932180
92membrane raft organization (GO:0031579)3.17633937
93ribosomal small subunit assembly (GO:0000028)3.14954993
94organ formation (GO:0048645)3.14652022
95cartilage development involved in endochondral bone morphogenesis (GO:0060351)3.13907086
96regulation of endothelial cell apoptotic process (GO:2000351)3.13363934
97chaperone mediated protein folding requiring cofactor (GO:0051085)3.12224918
98epithelial to mesenchymal transition (GO:0001837)3.11620117
99formation of primary germ layer (GO:0001704)3.11348389
100trabecula morphogenesis (GO:0061383)3.09471816
101muscle filament sliding (GO:0030049)3.08757407
102actin-myosin filament sliding (GO:0033275)3.08757407
103maturation of SSU-rRNA (GO:0030490)3.07196434
104neural crest cell development (GO:0014032)3.07073292
105regulation of endothelial cell chemotaxis (GO:2001026)3.06480040
106cyclic nucleotide catabolic process (GO:0009214)3.06442669
107arginine catabolic process (GO:0006527)3.05829897
108cellular response to gonadotropin stimulus (GO:0071371)3.04988352
109dendritic spine morphogenesis (GO:0060997)3.04367244
110protein refolding (GO:0042026)2.99280084
111regulation of cardioblast differentiation (GO:0051890)2.98299594
112heart valve formation (GO:0003188)2.98173155
113renal system development (GO:0072001)2.97515337
114regulation of MHC class I biosynthetic process (GO:0045343)2.97246874
115mesenchymal cell development (GO:0014031)2.96970193
116cellular response to arsenic-containing substance (GO:0071243)2.95118731
117vasculogenesis (GO:0001570)2.93660457
118positive regulation of interleukin-8 secretion (GO:2000484)2.93307760
119negative regulation by host of viral transcription (GO:0043922)2.92743874
120transcription from mitochondrial promoter (GO:0006390)2.92628375
121negative regulation of myoblast differentiation (GO:0045662)2.91756798
122blood vessel remodeling (GO:0001974)2.91529749
123negative regulation of vascular endothelial growth factor receptor signaling pathway (GO:0030948)2.90726130
124alditol metabolic process (GO:0019400)2.90656311
125mammary gland development (GO:0030879)2.90050096
126histamine transport (GO:0051608)2.89835011
127negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.89681270
128positive regulation of stem cell differentiation (GO:2000738)2.88769822
129positive regulation of odontogenesis (GO:0042482)2.86798073
130sphingomyelin metabolic process (GO:0006684)2.86633786
131regulation of Rap GTPase activity (GO:0032317)2.86341419
132potassium ion import (GO:0010107)2.86293278
133regulation of cholesterol efflux (GO:0010874)2.82763022
134cellular response to fluid shear stress (GO:0071498)2.81761408
135substrate-dependent cell migration (GO:0006929)2.81405145
136regulation of macrophage chemotaxis (GO:0010758)2.81162534
137regulation of cardioblast proliferation (GO:0003264)2.80784831
138regulation of secondary heart field cardioblast proliferation (GO:0003266)2.80784831
139embryonic foregut morphogenesis (GO:0048617)2.80583286
140blood vessel maturation (GO:0001955)2.79341075
141regulation of B cell receptor signaling pathway (GO:0050855)2.78704048
142basement membrane organization (GO:0071711)2.78488379
143smooth muscle cell differentiation (GO:0051145)2.78130401
144regulation of smooth muscle cell differentiation (GO:0051150)2.78059322
145actin-mediated cell contraction (GO:0070252)2.77922756
146endothelial cell chemotaxis (GO:0035767)2.77363097
147lipopolysaccharide biosynthetic process (GO:0009103)2.76702604
148keratan sulfate catabolic process (GO:0042340)2.75386683
149heart trabecula formation (GO:0060347)2.74971254
150regulation of receptor binding (GO:1900120)2.73336136
151regulation of transforming growth factor beta2 production (GO:0032909)2.73215085
152regulation of regulatory T cell differentiation (GO:0045589)2.72825543
153regulation of cell fate specification (GO:0042659)2.72172032
154regulation of sarcomere organization (GO:0060297)2.71279238
155negative regulation of Rho protein signal transduction (GO:0035024)2.71081466
156blood vessel endothelial cell migration (GO:0043534)2.70864429
157diterpenoid biosynthetic process (GO:0016102)2.69215547
158mesenchymal cell proliferation (GO:0010463)2.68359414
159mRNA transcription from RNA polymerase II promoter (GO:0042789)2.68270338
160regulation of cell proliferation involved in heart morphogenesis (GO:2000136)2.68201246
161positive regulation of erythrocyte differentiation (GO:0045648)2.68025813
162germ cell migration (GO:0008354)2.67249577
163cardiac epithelial to mesenchymal transition (GO:0060317)2.67179954
164regulation of synapse structural plasticity (GO:0051823)2.65966573
165positive regulation of gamma-delta T cell activation (GO:0046645)2.65911446
166mechanosensory behavior (GO:0007638)2.64526983
167trabecula formation (GO:0060343)2.64393453
168positive regulation of natural killer cell mediated immunity (GO:0002717)2.64027867
169regulation of B cell differentiation (GO:0045577)2.63574544
170endothelial cell development (GO:0001885)2.62914629
171short-term memory (GO:0007614)2.60855990
172outflow tract morphogenesis (GO:0003151)2.59903442
173positive regulation by host of viral transcription (GO:0043923)2.59855875
174keratan sulfate biosynthetic process (GO:0018146)2.59496627
175tongue development (GO:0043586)2.59300212
176regulation of mesenchymal cell proliferation (GO:0010464)2.59065052
177membrane budding (GO:0006900)2.58428252
178cardiac muscle cell proliferation (GO:0060038)2.58042425
179response to fluid shear stress (GO:0034405)2.57665434
180ventricular septum morphogenesis (GO:0060412)2.56601112
181positive regulation of endothelial cell apoptotic process (GO:2000353)2.55563511
182positive regulation of extrinsic apoptotic signaling pathway in absence of ligand (GO:2001241)2.55341572
183granulocyte differentiation (GO:0030851)2.54641656

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human9.93562538
2STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse5.78050762
3TRIM28_21343339_ChIP-Seq_HEK293_Human5.28887206
4FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse5.15957469
5FOXP3_17237761_ChIP-ChIP_TREG_Mouse4.57623132
6SMAD_19615063_ChIP-ChIP_OVARY_Human3.79641979
7BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse3.69247597
8WT1_19549856_ChIP-ChIP_CCG9911_Human3.34896241
9GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse3.04532415
10ESR1_20079471_ChIP-ChIP_T-47D_Human2.88882471
11EED_16625203_ChIP-ChIP_MESCs_Mouse2.88796452
12SCL_19346495_ChIP-Seq_HPC-7_Human2.80507108
13KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.73564789
14KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.73564789
15KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.73564789
16AR_21572438_ChIP-Seq_LNCaP_Human2.68878622
17RUNX_20019798_ChIP-Seq_JUKART_Human2.65463161
18SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.61341881
19PHC1_16625203_ChIP-ChIP_MESCs_Mouse2.60645060
20SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.59815324
21IRF8_22096565_ChIP-ChIP_GC-B_Human2.47528502
22PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.43715043
23CDX2_19796622_ChIP-Seq_MESCs_Mouse2.40437503
24GATA2_21666600_ChIP-Seq_HMVEC_Human2.37180308
25EP300_21415370_ChIP-Seq_HL-1_Mouse2.34559366
26CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human2.32625977
27TP63_17297297_ChIP-ChIP_HaCaT_Human2.31661662
28HIF1A_21447827_ChIP-Seq_MCF-7_Human2.29595117
29GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.27500518
30HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.16916197
31EZH2_18974828_ChIP-Seq_MESCs_Mouse2.16560925
32RNF2_18974828_ChIP-Seq_MESCs_Mouse2.16560925
33STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.12795044
34JARID2_20064375_ChIP-Seq_MESCs_Mouse2.10406966
35EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse2.04571561
36ESR1_21235772_ChIP-Seq_MCF-7_Human1.99070153
37SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.98902229
38SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.96540447
39STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.96457991
40ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.91122349
41RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.89464837
42NOTCH1_21737748_ChIP-Seq_TLL_Human1.84312494
43CLOCK_20551151_ChIP-Seq_293T_Human1.82554119
44SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.79916640
45GBX2_23144817_ChIP-Seq_PC3_Human1.74784060
46EZH2_27304074_Chip-Seq_ESCs_Mouse1.74355316
47IGF1R_20145208_ChIP-Seq_DFB_Human1.73719924
48ZFP57_27257070_Chip-Seq_ESCs_Mouse1.71800257
49CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.69428978
50BCAT_22108803_ChIP-Seq_LS180_Human1.69057132
51TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.66045967
52MYB_26560356_Chip-Seq_TH2_Human1.65261433
53LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.64779986
54CJUN_26792858_Chip-Seq_BT549_Human1.64702708
55FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.62857201
56ZNF217_24962896_ChIP-Seq_MCF-7_Human1.61904872
57TAF15_26573619_Chip-Seq_HEK293_Human1.61585127
58MTF2_20144788_ChIP-Seq_MESCs_Mouse1.59017542
59TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.58712195
60JARID2_20075857_ChIP-Seq_MESCs_Mouse1.55215662
61IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.54629816
62FLI1_27457419_Chip-Seq_LIVER_Mouse1.51188750
63TP63_19390658_ChIP-ChIP_HaCaT_Human1.49278896
64POU5F1_16153702_ChIP-ChIP_HESCs_Human1.46839858
65VDR_22108803_ChIP-Seq_LS180_Human1.46001938
66TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.41067138
67RBPJ_22232070_ChIP-Seq_NCS_Mouse1.39977220
68PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.39878624
69FOXO3_23340844_ChIP-Seq_DLD1_Human1.38112031
70NRF2_20460467_ChIP-Seq_MEFs_Mouse1.36701187
71NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.36701187
72PPAR_26484153_Chip-Seq_NCI-H1993_Human1.34949023
73MYB_26560356_Chip-Seq_TH1_Human1.34911708
74EGR1_19032775_ChIP-ChIP_M12_Human1.32933637
75SOX2_20726797_ChIP-Seq_SW620_Human1.32412828
76ESR2_21235772_ChIP-Seq_MCF-7_Human1.31997011
77WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.31754535
78CBX2_27304074_Chip-Seq_ESCs_Mouse1.31203139
79NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.30197718
80* EWS_26573619_Chip-Seq_HEK293_Human1.29097762
81RARG_19884340_ChIP-ChIP_MEFs_Mouse1.27363061
82PIAS1_25552417_ChIP-Seq_VCAP_Human1.25516061
83KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse1.25312843
84OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.24034943
85NR3C1_21868756_ChIP-Seq_MCF10A_Human1.23559302
86IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.23016303
87ELF1_17652178_ChIP-ChIP_JURKAT_Human1.22514831
88GATA1_19941826_ChIP-Seq_K562_Human1.22153982
89CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.21488016
90SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.20503941
91ISL1_27105846_Chip-Seq_CPCs_Mouse1.18619132
92BMI1_23680149_ChIP-Seq_NPCS_Mouse1.18477551
93SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.17922919
94IKZF1_21737484_ChIP-ChIP_HCT116_Human1.17090128
95SMAD3_21741376_ChIP-Seq_EPCs_Human1.16565110
96RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.16029965
97TCF4_18268006_ChIP-ChIP_LS174T_Human1.15815106
98DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.15247827
99GATA3_27048872_Chip-Seq_THYMUS_Human1.14921261
100PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.13462171
101RNF2_27304074_Chip-Seq_NSC_Mouse1.12426636
102RING1B_27294783_Chip-Seq_NPCs_Mouse1.12287552
103PCGF2_27294783_Chip-Seq_NPCs_Mouse1.12083787
104SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.10410221
105PCGF2_27294783_Chip-Seq_ESCs_Mouse1.06552927
106EZH2_27294783_Chip-Seq_ESCs_Mouse1.06438826
107GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.05822355
108SUZ12_27294783_Chip-Seq_ESCs_Mouse1.05750342
109STAT4_19710469_ChIP-ChIP_TH1__Mouse1.05152424
110RNF2_27304074_Chip-Seq_ESCs_Mouse1.05054004
111KLF5_20875108_ChIP-Seq_MESCs_Mouse1.03254033
112SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.03159268
113SALL4_18804426_ChIP-ChIP_XEN_Mouse1.02846396
114* TOP2B_26459242_ChIP-Seq_MCF-7_Human1.02830364
115TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.02682310
116VDR_24787735_ChIP-Seq_THP-1_Human1.01611710
117BRD4_25478319_ChIP-Seq_HGPS_Human1.01432329
118IRF1_19129219_ChIP-ChIP_H3396_Human1.01322343
119EZH2_27294783_Chip-Seq_NPCs_Mouse0.99699644
120GATA3_26560356_Chip-Seq_TH2_Human0.98412481
121NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.96140158
122* TP53_18474530_ChIP-ChIP_U2OS_Human0.95337230
123FUS_26573619_Chip-Seq_HEK293_Human0.94148369
124POU3F2_20337985_ChIP-ChIP_501MEL_Human0.93928694
125RING1B_27294783_Chip-Seq_ESCs_Mouse0.93806240
126SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.93109243
127NFIB_24661679_ChIP-Seq_LUNG_Mouse0.92974825
128* LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.92378080
129P300_19829295_ChIP-Seq_ESCs_Human0.91950701
130FOXM1_26456572_ChIP-Seq_MCF-7_Human0.91639979
131TP53_20018659_ChIP-ChIP_R1E_Mouse0.90965213
132* FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.90333328
133RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.89739701
134MECOM_23826213_ChIP-Seq_KASUMI_Mouse0.89591209
135CDX2_20551321_ChIP-Seq_CACO-2_Human0.88868041
136RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.88037851
137RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.87192513
138* GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.86202344
139SMAD4_21799915_ChIP-Seq_A2780_Human0.86125505
140TBX20_22328084_ChIP-Seq_HEART_Mouse0.85890461
141TBX20_22080862_ChIP-Seq_HEART_Mouse0.85890461
142TCF4_22108803_ChIP-Seq_LS180_Human0.85750745
143JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.85264603
144UTX_26944678_Chip-Seq_JUKART_Human0.83850263
145IRF8_21731497_ChIP-ChIP_J774_Mouse0.81845057
146TP53_22573176_ChIP-Seq_HFKS_Human0.79929005
147GATA3_26560356_Chip-Seq_TH1_Human0.79900131
148MAF_26560356_Chip-Seq_TH1_Human0.78933877
149PRDM14_20953172_ChIP-Seq_ESCs_Human0.78732106
150ELK1_19687146_ChIP-ChIP_HELA_Human0.75386592
151MYB_21317192_ChIP-Seq_ERMYB_Mouse0.73514971
152SUZ12_27294783_Chip-Seq_NPCs_Mouse0.73193395
153CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.72693819
154* SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.71399025

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005167_abnormal_blood-brain_barrier4.43719333
2MP0001879_abnormal_lymphatic_vessel4.38274184
3MP0009379_abnormal_foot_pigmentation4.32930142
4MP0004272_abnormal_basement_membrane4.19747992
5MP0002396_abnormal_hematopoietic_system3.58834717
6MP0009384_cardiac_valve_regurgitation3.10826822
7MP0008438_abnormal_cutaneous_collagen2.92737529
8MP0003122_maternal_imprinting2.89270706
9MP0005085_abnormal_gallbladder_physiolo2.75571266
10MP0005503_abnormal_tendon_morphology2.73383462
11MP0004147_increased_porphyrin_level2.68430862
12MP0002933_joint_inflammation2.60139793
13MP0002282_abnormal_trachea_morphology2.56410735
14MP0002138_abnormal_hepatobiliary_system2.41014589
15MP0003011_delayed_dark_adaptation2.40187646
16MP0000465_gastrointestinal_hemorrhage2.37595934
17MP0010368_abnormal_lymphatic_system2.36385076
18MP0003763_abnormal_thymus_physiology2.33944791
19MP0003279_aneurysm2.32529033
20MP0002009_preneoplasia2.30657648
21MP0009697_abnormal_copulation2.26746923
22MP0006054_spinal_hemorrhage2.20477190
23MP0005623_abnormal_meninges_morphology2.12346105
24MP0002938_white_spotting2.10286033
25MP0009250_abnormal_appendicular_skeleto2.08781258
26MP0005084_abnormal_gallbladder_morpholo2.05120441
27MP0003638_abnormal_response/metabolism_2.03519408
28MP0004484_altered_response_of2.00205372
29MP0005408_hypopigmentation1.99563043
30MP0005171_absent_coat_pigmentation1.99024044
31MP0004084_abnormal_cardiac_muscle1.93374563
32MP0003123_paternal_imprinting1.89859676
33MP0001851_eye_inflammation1.80794143
34MP0003724_increased_susceptibility_to1.80362525
35MP0002736_abnormal_nociception_after1.78619071
36MP0000013_abnormal_adipose_tissue1.71632548
37MP0002249_abnormal_larynx_morphology1.62124238
38MP0000163_abnormal_cartilage_morphology1.61293549
39MP0002127_abnormal_cardiovascular_syste1.59256202
40MP0009278_abnormal_bone_marrow1.57385816
41MP0001188_hyperpigmentation1.57325792
42MP0002148_abnormal_hypersensitivity_rea1.55688379
43MP0005409_darkened_coat_color1.53325569
44MP0004883_abnormal_blood_vessel1.51681696
45MP0001800_abnormal_humoral_immune1.51353899
46MP0002398_abnormal_bone_marrow1.48005723
47MP0002420_abnormal_adaptive_immunity1.46854401
48MP0002166_altered_tumor_susceptibility1.45098156
49MP0002405_respiratory_system_inflammati1.44469371
50MP0001819_abnormal_immune_cell1.43151313
51MP0000343_altered_response_to1.41808699
52MP0001542_abnormal_bone_strength1.40167094
53MP0002723_abnormal_immune_serum1.38711038
54MP0001968_abnormal_touch/_nociception1.38172098
55MP0003121_genomic_imprinting1.38082303
56MP0002295_abnormal_pulmonary_circulatio1.37998288
57MP0003385_abnormal_body_wall1.37890237
58MP0000762_abnormal_tongue_morphology1.36439987
59MP0002115_abnormal_skeleton_extremities1.36081722
60MP0003950_abnormal_plasma_membrane1.34287349
61MP0005275_abnormal_skin_tensile1.33508646
62MP0005508_abnormal_skeleton_morphology1.30959481
63MP0001873_stomach_inflammation1.30162689
64MP0009333_abnormal_splenocyte_physiolog1.29014238
65MP0000049_abnormal_middle_ear1.28325666
66MP0001764_abnormal_homeostasis1.27677031
67MP0000516_abnormal_urinary_system1.26987967
68MP0005367_renal/urinary_system_phenotyp1.26987967
69MP0004134_abnormal_chest_morphology1.26983465
70MP0003943_abnormal_hepatobiliary_system1.25439577
71MP0005025_abnormal_response_to1.24559185
72MP0005595_abnormal_vascular_smooth1.24442837
73MP0002972_abnormal_cardiac_muscle1.23115312
74MP0002896_abnormal_bone_mineralization1.20915725
75MP0000767_abnormal_smooth_muscle1.20466490
76MP0004381_abnormal_hair_follicle1.19528698
77MP0000703_abnormal_thymus_morphology1.19318610
78MP0008775_abnormal_heart_ventricle1.19314953
79MP0002108_abnormal_muscle_morphology1.19270346
80MP0000716_abnormal_immune_system1.19211741
81MP0001270_distended_abdomen1.18734849
82MP0005164_abnormal_response_to1.17434219
83MP0005671_abnormal_response_to1.13900153
84MP0003303_peritoneal_inflammation1.12948746
85MP0002452_abnormal_antigen_presenting1.12675872
86MP0002925_abnormal_cardiovascular_devel1.12376141
87MP0006138_congestive_heart_failure1.12206603
88MP0009785_altered_susceptibility_to1.12080798
89MP0000230_abnormal_systemic_arterial1.11971854
90MP0002128_abnormal_blood_circulation1.11970902
91MP0003787_abnormal_imprinting1.11947027
92MP0005000_abnormal_immune_tolerance1.11686477
93MP0002429_abnormal_blood_cell1.10786335
94MP0005330_cardiomyopathy1.09686503
95MP0004808_abnormal_hematopoietic_stem1.08963740
96MP0001835_abnormal_antigen_presentation1.07829194
97MP0000689_abnormal_spleen_morphology1.07537994
98MP0010630_abnormal_cardiac_muscle1.05827123
99MP0002722_abnormal_immune_system1.05665636
100MP0004036_abnormal_muscle_relaxation1.04951520
101MP0002113_abnormal_skeleton_development1.04889424
102MP0000249_abnormal_blood_vessel1.03763836
103MP0003091_abnormal_cell_migration1.03701864
104MP0005423_abnormal_somatic_nervous1.01649584
105MP0001299_abnormal_eye_distance/1.01206457
106MP0003828_pulmonary_edema1.01162675
107MP0008873_increased_physiological_sensi1.00070284
108MP0005620_abnormal_muscle_contractility0.98703781
109MP0005464_abnormal_platelet_physiology0.98025606
110MP0002419_abnormal_innate_immunity0.97538959
111MP0004145_abnormal_muscle_electrophysio0.96613142
112MP0001614_abnormal_blood_vessel0.95727030
113MP0005248_abnormal_Harderian_gland0.95324213
114MP0004085_abnormal_heartbeat0.93956184
115MP0002909_abnormal_adrenal_gland0.92615807
116MP0001191_abnormal_skin_condition0.90467902
117MP0000751_myopathy0.90093219
118MP0001243_abnormal_dermal_layer0.87835714
119MP0003935_abnormal_craniofacial_develop0.87614456
120MP0004215_abnormal_myocardial_fiber0.87612630
121MP0002006_tumorigenesis0.86753796
122MP0005390_skeleton_phenotype0.86208044
123MP0001986_abnormal_taste_sensitivity0.84334408
124MP0000733_abnormal_muscle_development0.84176973
125MP0000749_muscle_degeneration0.82963712
126MP0001664_abnormal_digestion0.81486478
127MP0002928_abnormal_bile_duct0.81460112
128MP0002109_abnormal_limb_morphology0.79913783
129MP0005385_cardiovascular_system_phenoty0.79681693
130MP0001544_abnormal_cardiovascular_syste0.79681693
131MP0005501_abnormal_skin_physiology0.79680361
132MP0001919_abnormal_reproductive_system0.79319367
133MP0002932_abnormal_joint_morphology0.78511700
134MP0004019_abnormal_vitamin_homeostasis0.75767124
135MP0005645_abnormal_hypothalamus_physiol0.73719108
136MP0002332_abnormal_exercise_endurance0.73562306
137MP0001958_emphysema0.73086334
138MP0010155_abnormal_intestine_physiology0.72412397
139MP0002116_abnormal_craniofacial_bone0.72396167
140MP0005165_increased_susceptibility_to0.71877149
141MP0003866_abnormal_defecation0.70713267
142MP0002098_abnormal_vibrissa_morphology0.70564692
143MP0000266_abnormal_heart_morphology0.69999343
144MP0008872_abnormal_physiological_respon0.69759681
145MP0003755_abnormal_palate_morphology0.69569235
146MP0002086_abnormal_extraembryonic_tissu0.69036252
147MP0000537_abnormal_urethra_morphology0.68709400
148MP0003300_gastrointestinal_ulcer0.67461422
149MP0002163_abnormal_gland_morphology0.67403922
150MP0001533_abnormal_skeleton_physiology0.66908370
151MP0003075_altered_response_to0.64965757
152MP0008469_abnormal_protein_level0.61630817
153MP0005397_hematopoietic_system_phenotyp0.61617174
154MP0001545_abnormal_hematopoietic_system0.61617174
155MP0001790_abnormal_immune_system0.60998923
156MP0005387_immune_system_phenotype0.60998923
157MP0008058_abnormal_DNA_repair0.59155743
158MP0004130_abnormal_muscle_cell0.57519747
159MP0001845_abnormal_inflammatory_respons0.57079779
160MP0001784_abnormal_fluid_regulation0.56710572
161MP0005166_decreased_susceptibility_to0.55244494

Predicted human phenotypes

RankGene SetZ-score
1Epiphyseal dysplasia (HP:0002656)6.78912234
2Delayed CNS myelination (HP:0002188)5.96304335
3Vitreoretinal degeneration (HP:0000655)5.91748926
4Hyperlipoproteinemia (HP:0010980)5.71095524
5Irregular epiphyses (HP:0010582)5.32859435
6Hypoplastic ischia (HP:0003175)5.08797155
7Abnormality of the ischium (HP:0003174)4.45771304
8Diplopia (HP:0000651)4.43214675
9Abnormality of binocular vision (HP:0011514)4.43214675
10Cupped ribs (HP:0000887)4.40017368
11Aplastic anemia (HP:0001915)4.31055313
12Pancreatic islet-cell hyperplasia (HP:0004510)4.14801296
13Aplasia/Hypoplasia of the pubic bone (HP:0009104)4.13909280
14Exercise-induced muscle cramps (HP:0003710)4.01385354
15Decreased central vision (HP:0007663)3.80514317
16Neonatal short-limb short stature (HP:0008921)3.77737665
17Hypotrichosis (HP:0001006)3.71610278
18Stenosis of the external auditory canal (HP:0000402)3.68164450
19Flat capital femoral epiphysis (HP:0003370)3.64729415
20Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)3.62748666
21Absent epiphyses (HP:0010577)3.62748666
22Abnormal tarsal ossification (HP:0008369)3.58017461
23IgM deficiency (HP:0002850)3.45615642
24Small epiphyses (HP:0010585)3.45054311
25Lymphedema (HP:0001004)3.41635088
26Congenital, generalized hypertrichosis (HP:0004540)3.36641963
27IgG deficiency (HP:0004315)3.35623045
28Nonimmune hydrops fetalis (HP:0001790)3.32133353
29Autoimmune hemolytic anemia (HP:0001890)3.27164555
30Stomach cancer (HP:0012126)3.22547222
31Woolly hair (HP:0002224)3.17406218
32Absent rod-and cone-mediated responses on ERG (HP:0007688)3.14370837
33Delayed epiphyseal ossification (HP:0002663)3.13065471
34Osteoarthritis (HP:0002758)3.10840509
35Spontaneous hematomas (HP:0007420)3.08957812
36Arthropathy (HP:0003040)3.06217293
37Absent eyebrow (HP:0002223)3.00401170
38Mild short stature (HP:0003502)2.93244791
39Abnormality of femoral epiphyses (HP:0006499)2.92692854
40Abnormality involving the epiphyses of the lower limbs (HP:0006500)2.92692854
41Arterial tortuosity (HP:0005116)2.90480051
42Hepatoblastoma (HP:0002884)2.88217074
43Type 1 muscle fiber predominance (HP:0003803)2.85515013
44Thyroid-stimulating hormone excess (HP:0002925)2.84878664
45Abnormality of the prostate (HP:0008775)2.77346064
46Protrusio acetabuli (HP:0003179)2.77322013
47Stomatitis (HP:0010280)2.76084679
48Metaphyseal dysplasia (HP:0100255)2.75749787
49Abnormality of T cell number (HP:0011839)2.75110095
50Genu varum (HP:0002970)2.74029876
51Large hands (HP:0001176)2.72740680
52Metaphyseal cupping (HP:0003021)2.70204726
53Large for gestational age (HP:0001520)2.69546054
54Abnormality of carpal bone ossification (HP:0006257)2.69332740
55Abnormal delayed hypersensitivity skin test (HP:0002963)2.68919907
56Aortic dissection (HP:0002647)2.68832744
57Paralysis (HP:0003470)2.68729710
58Hemiparesis (HP:0001269)2.64507333
59Vascular tortuosity (HP:0004948)2.63188231
60Premature rupture of membranes (HP:0001788)2.62367458
61Bile duct proliferation (HP:0001408)2.60313572
62Abnormal biliary tract physiology (HP:0012439)2.60313572
63Hip contracture (HP:0003273)2.60212133
64Flattened epiphyses (HP:0003071)2.57844843
65Palpebral edema (HP:0100540)2.57328585
66Abnormality of the phalanges of the 2nd finger (HP:0009541)2.57076872
67Abnormality of the epiphysis of the femoral head (HP:0010574)2.52648478
68Elevated erythrocyte sedimentation rate (HP:0003565)2.49962101
69Annular pancreas (HP:0001734)2.49374154
70Decreased number of large peripheral myelinated nerve fibers (HP:0003387)2.48425128
71Round ear (HP:0100830)2.48275735
72Periorbital edema (HP:0100539)2.48228450
73Reduced subcutaneous adipose tissue (HP:0003758)2.46234699
74Abnormality of B cell number (HP:0010975)2.45214336
75Follicular hyperkeratosis (HP:0007502)2.44821072
76Abnormal pupillary function (HP:0007686)2.43765537
77Abnormal foot bone ossification (HP:0010675)2.43106843
78Abnormal rod and cone electroretinograms (HP:0008323)2.42929189
79Pulmonary artery stenosis (HP:0004415)2.42687798
80Abnormality of the vertebral endplates (HP:0005106)2.40242562
81Platyspondyly (HP:0000926)2.39703544
82T lymphocytopenia (HP:0005403)2.38332595
83Tongue fasciculations (HP:0001308)2.36725639
84Spinal rigidity (HP:0003306)2.34435678
85Hypoglycemic coma (HP:0001325)2.34375984
86Coxa vara (HP:0002812)2.34214228
87Facial edema (HP:0000282)2.33934333
88Hypoglycemic seizures (HP:0002173)2.33670642
89Flat acetabular roof (HP:0003180)2.33533956
90Limited hip movement (HP:0008800)2.32497357
91Absent hand (HP:0004050)2.32277512
92Attenuation of retinal blood vessels (HP:0007843)2.31953503
93Lymphangioma (HP:0100764)2.31364573
94Abnormality of incisor morphology (HP:0011063)2.29437950
95Reticulocytopenia (HP:0001896)2.25006136
96Cervical subluxation (HP:0003308)2.24896018
97Abnormality of the femoral head (HP:0003368)2.24884163
98Absent eyelashes (HP:0000561)2.24790575
99Prostate neoplasm (HP:0100787)2.24584903
100Severe combined immunodeficiency (HP:0004430)2.23756216
1013-Methylglutaconic aciduria (HP:0003535)2.22998579
102Thyroiditis (HP:0100646)2.22859414
103Aplasia/Hypoplasia of the spleen (HP:0010451)2.22296514
104Abnormality of the pancreatic islet cells (HP:0006476)2.22265336
105Abnormality of endocrine pancreas physiology (HP:0012093)2.22265336
106Papilledema (HP:0001085)2.22160166
107Growth hormone excess (HP:0000845)2.16802468
108Menstrual irregularities (HP:0000858)2.13499008
109Neoplasm of the adrenal cortex (HP:0100641)2.12737572
110Abnormal hand bone ossification (HP:0010660)2.12361236
111Thin ribs (HP:0000883)2.12140689
112Hypoplasia of the uterus (HP:0000013)2.10541245
113Hematochezia (HP:0002573)2.10372275
114Abnormal ossification of hand bones (HP:0005921)2.09220049
115Abnormality of T cells (HP:0002843)2.09125224
116Irregular vertebral endplates (HP:0003301)2.07970357
117Muscle fibrillation (HP:0010546)2.07436880
118Abnormal vertebral ossification (HP:0100569)2.07186772
119Hypoplasia of the capital femoral epiphysis (HP:0003090)2.07170394
120Fair hair (HP:0002286)2.04162675
121Joint swelling (HP:0001386)2.02697478
122Increased IgM level (HP:0003496)2.02517507
123Diastasis recti (HP:0001540)2.02036502
124Polydipsia (HP:0001959)2.02016584
125Abnormal drinking behavior (HP:0030082)2.02016584
126Abnormality of the pubic bones (HP:0003172)2.01856344
127Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)2.01591122
128Abnormality of the proximal phalanges of the hand (HP:0009834)2.01377734
129Exostoses (HP:0100777)2.00730025
130Hyperinsulinemic hypoglycemia (HP:0000825)2.00567351
131Thoracolumbar scoliosis (HP:0002944)1.99418800
132Vertebral hypoplasia (HP:0008417)1.99218298
133Aplasia/Hypoplasia of the vertebrae (HP:0008515)1.99218298
134Abnormality of the left ventricular outflow tract (HP:0011103)1.96631180
135Subaortic stenosis (HP:0001682)1.96631180
136Short femoral neck (HP:0100864)1.94673903
137Prolonged bleeding time (HP:0003010)1.93516790
138Hemiplegia (HP:0002301)1.92637085
139Short hallux (HP:0010109)1.91279513
140Panhypogammaglobulinemia (HP:0003139)1.90855185
141Mitral valve prolapse (HP:0001634)1.90504527
142Hydroureter (HP:0000072)1.90351431
143Cutaneous melanoma (HP:0012056)1.90351034
144Mesomelia (HP:0003027)1.89987314
145IgA deficiency (HP:0002720)1.89280390
146Aplasia/Hypoplasia of the hallux (HP:0008362)1.87872154
147Abnormality of the periventricular white matter (HP:0002518)1.85156300
148Aplasia/hypoplasia of the uterus (HP:0008684)1.84439337
149Subacute progressive viral hepatitis (HP:0006572)1.84419296
150Hypokalemic alkalosis (HP:0001949)1.82688176
151Autoimmune thrombocytopenia (HP:0001973)1.82392958
152Asplenia (HP:0001746)1.81738743
153Nemaline bodies (HP:0003798)1.81377697
154Ovoid vertebral bodies (HP:0003300)1.80632898
155Abnormality of the vitreous humor (HP:0004327)1.79723698
156Onycholysis (HP:0001806)1.79194583
157Confusion (HP:0001289)1.78672974
158Tracheomalacia (HP:0002779)1.78574020
159Recurrent bronchitis (HP:0002837)1.78320598
160Short chin (HP:0000331)1.78254749
161Waddling gait (HP:0002515)1.77310883
162Broad metatarsal (HP:0001783)1.76850318
163Cutis marmorata (HP:0000965)1.76047147
164Protuberant abdomen (HP:0001538)1.76041202
165Muscle stiffness (HP:0003552)1.75528976
166Abnormality of the nasal mucosa (HP:0000433)1.74551004
167Abnormality of T cell physiology (HP:0011840)1.74530534
168Teleangiectasia of the skin (HP:0100585)1.73483048
169Abnormality of the lumbar spine (HP:0100712)1.73234944
170Methylmalonic aciduria (HP:0012120)1.72995545
171Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)1.72543031
172Abnormality of the frontal sinuses (HP:0002687)1.71616995
173Abnormality of the axillary hair (HP:0100134)1.70079719
174Abnormality of secondary sexual hair (HP:0009888)1.70079719
175Metaphyseal irregularity (HP:0003025)1.69612130
176Abnormality of the 2nd finger (HP:0004100)1.68543518
177Aplasia/Hypoplasia involving the femoral head and neck (HP:0009108)1.68384926
178Mitral stenosis (HP:0001718)1.67591005
179Wrist flexion contracture (HP:0001239)1.66721128
180Adactyly (HP:0009776)1.65750273
181Absent frontal sinuses (HP:0002688)1.65724071
182Aplasia/Hypoplasia involving the sinuses (HP:0009120)1.65394890

Predicted kinase interactions (KEA)

RankGene SetZ-score
1KDR8.08485973
2TSSK65.13028401
3NLK4.11276753
4TIE13.65419386
5AKT32.81964080
6GRK12.79843253
7NUAK12.75348984
8INSRR2.70390869
9BMPR1B2.69391613
10PTK2B2.69115409
11TXK2.68832446
12OBSCN2.53233190
13BMPR22.46111473
14PRKG22.21596413
15STK242.20721617
16DDR22.11774727
17MUSK2.04159381
18MAP3K121.91982765
19MYLK1.86138638
20PNCK1.84313767
21PIM11.80914667
22MAP3K111.70160304
23MAP3K31.69262561
24FGFR21.53583306
25TGFBR21.53568402
26VRK11.53524085
27IRAK21.53357923
28IRAK41.46305164
29MST41.45787669
30NME11.39602809
31WEE11.36910709
32ITK1.27540532
33TRIB31.26969680
34PINK11.25423374
35MAPK121.22535014
36EIF2AK31.22045529
37MAP4K21.21607108
38TNK21.19768964
39NTRK31.18663376
40MAPK131.16445073
41PAK21.13385807
42NTRK21.12287028
43LIMK11.10377147
44MAP2K21.09188829
45FGFR31.09027671
46TAOK31.07926315
47MAPKAPK31.05684790
48EPHB21.05294484
49ZAK1.04085469
50STK31.02468194
51INSR0.97882060
52OXSR10.96724865
53RIPK40.95899796
54ROCK10.95611759
55VRK20.95374178
56MAPK150.91084664
57BTK0.90652274
58PDGFRA0.89260261
59TESK10.85448679
60SRPK10.84970714
61FRK0.84769412
62SIK30.84608396
63MET0.76420032
64MAPK70.73640978
65IRAK10.73151684
66TBK10.73025736
67IKBKE0.71566709
68PDGFRB0.70817444
69PDK20.70664977
70IGF1R0.68758165
71MAP4K10.66424011
72PRKCH0.64886990
73LRRK20.64611397
74ILK0.63638178
75PRKD20.63188424
76TRPM70.62895686
77AKT20.60960153
78BCKDK0.59796151
79FER0.58882593
80SRC0.58782421
81FES0.58281134
82PRKAA20.58003961
83DAPK20.57591760
84BCR0.57400956
85NME20.55569216
86JAK30.55545462
87GSK3A0.55275808
88PTK60.55201888
89ZAP700.54644345
90CDK30.54155148
91TYRO30.53114739
92PRKD10.51837466
93JAK10.51581380
94CLK10.51206283
95TEC0.49747267
96CSNK1A1L0.47610147
97CDK90.47470694
98CSK0.46527826
99SYK0.45000550
100CASK0.44722042
101PAK40.44422405
102STK390.44214211
103RPS6KB20.44093227
104MAPKAPK50.42361839
105RPS6KA50.42017289
106PLK30.41931283
107MARK30.41867181
108MAP2K10.41043106
109CDK80.40382402
110EGFR0.38844478
111DMPK0.38641662
112PTK20.38439574
113MAP3K70.38326922
114PRKCQ0.37123159
115CDK60.37027574
116PLK20.37019993
117STK100.36759170
118TAOK10.35642801
119CAMK10.35212569
120KIT0.35179961
121PAK30.34249703
122PRKCE0.34012594
123PRKG10.33819621
124PIM20.32525406
125TGFBR10.32022806
126LCK0.31652711
127PRKCD0.31171143
128MKNK20.31001932
129CSF1R0.30766470
130MINK10.30281933
131LYN0.30096892
132IKBKB0.28606790
133MAPK110.28587784
134CSNK1G20.27510059
135MAPK40.26994421
136PRKD30.26828644
137FYN0.26340143
138FGR0.25181266
139DAPK30.24922491
140GRK60.24578874
141HIPK20.24190428
142MAPK30.23992819
143HCK0.23858654
144ERBB30.23857648
145STK160.23550197
146ABL10.22450915
147DYRK1B0.22445260
148SIK20.20636127
149SIK10.19924895
150PRKCA0.19413816
151NEK90.19327385
152DAPK10.19250587
153RPS6KA60.18941493
154ADRBK20.17163339
155PRKCG0.17097320
156PIK3CG0.15544022

Predicted pathways (KEGG)

RankGene SetZ-score
1ECM-receptor interaction_Homo sapiens_hsa045123.25769869
2Protein digestion and absorption_Homo sapiens_hsa049742.87362409
3Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005322.66823970
4Adherens junction_Homo sapiens_hsa045202.62586860
5Focal adhesion_Homo sapiens_hsa045102.57965551
6ABC transporters_Homo sapiens_hsa020102.51070079
7Nitrogen metabolism_Homo sapiens_hsa009102.33561537
8African trypanosomiasis_Homo sapiens_hsa051432.21014769
9Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054122.15109079
10Cell adhesion molecules (CAMs)_Homo sapiens_hsa045142.13785831
11Basal cell carcinoma_Homo sapiens_hsa052172.08472558
12TGF-beta signaling pathway_Homo sapiens_hsa043502.06816369
13Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.00938927
14Leukocyte transendothelial migration_Homo sapiens_hsa046701.98596610
15Prion diseases_Homo sapiens_hsa050201.88612231
16Hippo signaling pathway_Homo sapiens_hsa043901.88024202
17Antigen processing and presentation_Homo sapiens_hsa046121.87035949
18Protein export_Homo sapiens_hsa030601.83144133
19Dilated cardiomyopathy_Homo sapiens_hsa054141.78366090
20Graft-versus-host disease_Homo sapiens_hsa053321.78337216
21Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.71772484
22Ribosome_Homo sapiens_hsa030101.70273442
23Measles_Homo sapiens_hsa051621.65271075
24Wnt signaling pathway_Homo sapiens_hsa043101.64972773
25Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.61154499
26PI3K-Akt signaling pathway_Homo sapiens_hsa041511.59924747
27Dorso-ventral axis formation_Homo sapiens_hsa043201.59593068
28Vitamin digestion and absorption_Homo sapiens_hsa049771.54923118
29Thyroid cancer_Homo sapiens_hsa052161.50555419
30Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.49897249
31Glycerolipid metabolism_Homo sapiens_hsa005611.47964362
32Rap1 signaling pathway_Homo sapiens_hsa040151.45114580
33Proteoglycans in cancer_Homo sapiens_hsa052051.43597712
34Axon guidance_Homo sapiens_hsa043601.42483943
35Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.42389805
36HIF-1 signaling pathway_Homo sapiens_hsa040661.38082123
37AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.36676515
38Cardiac muscle contraction_Homo sapiens_hsa042601.34370141
39Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.34207012
40Primary immunodeficiency_Homo sapiens_hsa053401.33897409
41Melanogenesis_Homo sapiens_hsa049161.33082316
42Long-term depression_Homo sapiens_hsa047301.31175691
43Tight junction_Homo sapiens_hsa045301.30679776
44Hedgehog signaling pathway_Homo sapiens_hsa043401.28424863
45Proteasome_Homo sapiens_hsa030501.27975244
46Vascular smooth muscle contraction_Homo sapiens_hsa042701.27393244
47cGMP-PKG signaling pathway_Homo sapiens_hsa040221.25443180
48B cell receptor signaling pathway_Homo sapiens_hsa046621.22019999
49Viral myocarditis_Homo sapiens_hsa054161.20280908
50Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.19277021
51Type I diabetes mellitus_Homo sapiens_hsa049401.18861037
52TNF signaling pathway_Homo sapiens_hsa046681.18330315
53Platelet activation_Homo sapiens_hsa046111.18005054
54Morphine addiction_Homo sapiens_hsa050321.17750099
55Chemokine signaling pathway_Homo sapiens_hsa040621.17418849
56Jak-STAT signaling pathway_Homo sapiens_hsa046301.17307966
57Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.17054192
58Sphingolipid metabolism_Homo sapiens_hsa006001.16235994
59T cell receptor signaling pathway_Homo sapiens_hsa046601.11835639
60Phototransduction_Homo sapiens_hsa047441.11352387
61Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.09687662
62Oxytocin signaling pathway_Homo sapiens_hsa049211.09305599
63Intestinal immune network for IgA production_Homo sapiens_hsa046721.05340230
64Prostate cancer_Homo sapiens_hsa052151.05269918
65Mineral absorption_Homo sapiens_hsa049781.00215554
66Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.98783804
67Colorectal cancer_Homo sapiens_hsa052100.98732909
68Legionellosis_Homo sapiens_hsa051340.98457877
69Thyroid hormone signaling pathway_Homo sapiens_hsa049190.96665766
70Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.95895332
71Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.94130212
72Pathways in cancer_Homo sapiens_hsa052000.93779330
73Asthma_Homo sapiens_hsa053100.93286313
74Renal cell carcinoma_Homo sapiens_hsa052110.92811836
75Sphingolipid signaling pathway_Homo sapiens_hsa040710.92292274
76Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.91021622
77Hematopoietic cell lineage_Homo sapiens_hsa046400.89009401
78Ras signaling pathway_Homo sapiens_hsa040140.88385426
79Aldosterone synthesis and secretion_Homo sapiens_hsa049250.87247518
80Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.87118705
81Bile secretion_Homo sapiens_hsa049760.86862677
82Circadian entrainment_Homo sapiens_hsa047130.84264771
83Central carbon metabolism in cancer_Homo sapiens_hsa052300.83146892
84Regulation of actin cytoskeleton_Homo sapiens_hsa048100.82720567
85Pancreatic secretion_Homo sapiens_hsa049720.80951797
86Gastric acid secretion_Homo sapiens_hsa049710.80161816
87Ovarian steroidogenesis_Homo sapiens_hsa049130.79292571
88Cholinergic synapse_Homo sapiens_hsa047250.78761383
89Notch signaling pathway_Homo sapiens_hsa043300.78026360
90Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.78013519
91Gap junction_Homo sapiens_hsa045400.77600599
92Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.77336091
93Allograft rejection_Homo sapiens_hsa053300.77215592
94Influenza A_Homo sapiens_hsa051640.77165887
95alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.76046205
96Arginine and proline metabolism_Homo sapiens_hsa003300.75466923
97Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.75287251
98HTLV-I infection_Homo sapiens_hsa051660.74783801
99Autoimmune thyroid disease_Homo sapiens_hsa053200.73833274
100Serotonergic synapse_Homo sapiens_hsa047260.73669179
101Dopaminergic synapse_Homo sapiens_hsa047280.72763345
102NOD-like receptor signaling pathway_Homo sapiens_hsa046210.72671905
103Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.71581243
104MAPK signaling pathway_Homo sapiens_hsa040100.70806109
105Glutamatergic synapse_Homo sapiens_hsa047240.69978977
106Salivary secretion_Homo sapiens_hsa049700.69483432
107RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.68785189
108Transcriptional misregulation in cancer_Homo sapiens_hsa052020.66797888
109NF-kappa B signaling pathway_Homo sapiens_hsa040640.66681662
110Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.66444122
111Amphetamine addiction_Homo sapiens_hsa050310.65893516
112VEGF signaling pathway_Homo sapiens_hsa043700.65778604
113Amoebiasis_Homo sapiens_hsa051460.64376636
114Renin secretion_Homo sapiens_hsa049240.63691338
115MicroRNAs in cancer_Homo sapiens_hsa052060.63169511
116Phospholipase D signaling pathway_Homo sapiens_hsa040720.61309455
117Parkinsons disease_Homo sapiens_hsa050120.61020890
118Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.60894377
119Basal transcription factors_Homo sapiens_hsa030220.60485543
120Choline metabolism in cancer_Homo sapiens_hsa052310.59063852
121Toxoplasmosis_Homo sapiens_hsa051450.56886892
122Taste transduction_Homo sapiens_hsa047420.56383784
123Olfactory transduction_Homo sapiens_hsa047400.56001459
124Malaria_Homo sapiens_hsa051440.55412861
125Toll-like receptor signaling pathway_Homo sapiens_hsa046200.55383297
126Herpes simplex infection_Homo sapiens_hsa051680.55358204
127Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.55239869
128Insulin secretion_Homo sapiens_hsa049110.53732830
129Salmonella infection_Homo sapiens_hsa051320.53576191
130Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.53062931
131Rheumatoid arthritis_Homo sapiens_hsa053230.52403727
132Endometrial cancer_Homo sapiens_hsa052130.52107303
133Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.51492197
134Alzheimers disease_Homo sapiens_hsa050100.51469597
135Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.51286765
136Linoleic acid metabolism_Homo sapiens_hsa005910.51142046
137GABAergic synapse_Homo sapiens_hsa047270.50433992
138Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.49634262
139Calcium signaling pathway_Homo sapiens_hsa040200.49455899
140Oxidative phosphorylation_Homo sapiens_hsa001900.49435562
141Estrogen signaling pathway_Homo sapiens_hsa049150.48197514
142Leishmaniasis_Homo sapiens_hsa051400.47954256
143Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.47548243
144Maturity onset diabetes of the young_Homo sapiens_hsa049500.46997380
145Spliceosome_Homo sapiens_hsa030400.46609770
146Shigellosis_Homo sapiens_hsa051310.46168012
147Renin-angiotensin system_Homo sapiens_hsa046140.44932015
148Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.43884762
149Small cell lung cancer_Homo sapiens_hsa052220.43503171
150Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.43457550
151Acute myeloid leukemia_Homo sapiens_hsa052210.42102706
152cAMP signaling pathway_Homo sapiens_hsa040240.41666652
153Caffeine metabolism_Homo sapiens_hsa002320.40912639

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