ITM2B

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Amyloid precursor proteins are processed by beta-secretase and gamma-secretase to produce beta-amyloid peptides which form the characteristic plaques of Alzheimer disease. This gene encodes a transmembrane protein which is processed at the C-terminus by furin or furin-like proteases to produce a small secreted peptide which inhibits the deposition of beta-amyloid. Mutations which result in extension of the C-terminal end of the encoded protein, thereby increasing the size of the secreted peptide, are associated with two neurogenerative diseases, familial British dementia and familial Danish dementia. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of leukocyte mediated cytotoxicity (GO:0001911)5.71208978
2negative regulation of cell killing (GO:0031342)5.71208978
3positive regulation of gamma-delta T cell activation (GO:0046645)4.66458408
4antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.58453273
5antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.58453273
6detection of bacterium (GO:0016045)4.12239847
7detection of molecule of bacterial origin (GO:0032490)3.96078865
8antigen processing and presentation of endogenous antigen (GO:0019883)3.94682618
9detection of external biotic stimulus (GO:0098581)3.89855636
10negative regulation of lymphocyte mediated immunity (GO:0002707)3.65564077
11antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.63985320
12response to peptidoglycan (GO:0032494)3.55543281
13neutrophil activation (GO:0042119)3.52319638
14regulation of gamma-delta T cell activation (GO:0046643)3.46122345
15positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.40497042
16positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.39285211
17cellular extravasation (GO:0045123)3.37961320
18negative regulation of interleukin-12 production (GO:0032695)3.35861655
19detection of biotic stimulus (GO:0009595)3.32629455
20macrophage activation (GO:0042116)3.28319805
21negative regulation of leukocyte mediated immunity (GO:0002704)3.27235729
22response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.26324061
23response to host immune response (GO:0052572)3.26324061
24granulocyte activation (GO:0036230)3.22211192
25response to interleukin-15 (GO:0070672)3.19209577
26regulation of gamma-delta T cell differentiation (GO:0045586)3.15856090
27immunoglobulin mediated immune response (GO:0016064)3.15014886
28leukocyte aggregation (GO:0070486)3.11686422
29antigen processing and presentation via MHC class Ib (GO:0002475)3.09405606
30leukocyte migration involved in inflammatory response (GO:0002523)3.08620307
31regulation of mast cell degranulation (GO:0043304)3.01401149
32regulation of T-helper 2 cell differentiation (GO:0045628)2.99728598
33response to host (GO:0075136)2.99230362
34response to host defenses (GO:0052200)2.99230362
35response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.99230362
36myeloid cell activation involved in immune response (GO:0002275)2.98424857
37regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.97033816
38cellular response to interleukin-15 (GO:0071350)2.94827701
39regulation of myeloid leukocyte mediated immunity (GO:0002886)2.92712953
40negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.91910580
41positive regulation of mast cell activation (GO:0033005)2.89207265
42negative regulation of T cell mediated immunity (GO:0002710)2.85984765
43regulation of tolerance induction (GO:0002643)2.84533106
44regulation of leukocyte degranulation (GO:0043300)2.83938610
45regulation of T cell tolerance induction (GO:0002664)2.83247870
46interferon-gamma-mediated signaling pathway (GO:0060333)2.82368584
47neutrophil mediated immunity (GO:0002446)2.81306810
48regulation of mast cell activation involved in immune response (GO:0033006)2.74083560
49negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.71873046
50germinal center formation (GO:0002467)2.63454201
51regulation of regulated secretory pathway (GO:1903305)2.62962017
52regulation of T cell mediated cytotoxicity (GO:0001914)2.61449862
53tolerance induction (GO:0002507)2.60993163
54regulation of mast cell activation (GO:0033003)2.58952966
55regulation of regulatory T cell differentiation (GO:0045589)2.56821910
56dendritic cell chemotaxis (GO:0002407)2.56606176
57dendritic cell migration (GO:0036336)2.56053649
58adhesion of symbiont to host cell (GO:0044650)2.55465176
59virion attachment to host cell (GO:0019062)2.55465176
60B cell receptor signaling pathway (GO:0050853)2.51739514
61positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.51640088
62positive regulation of T cell mediated cytotoxicity (GO:0001916)2.49605139
63myeloid leukocyte mediated immunity (GO:0002444)2.49133088
64positive regulation of mast cell activation involved in immune response (GO:0033008)2.49073552
65positive regulation of mast cell degranulation (GO:0043306)2.49073552
66regulation of type 2 immune response (GO:0002828)2.48102647
67regulation of natural killer cell mediated immunity (GO:0002715)2.47117498
68regulation of natural killer cell mediated cytotoxicity (GO:0042269)2.47117498
69response to muramyl dipeptide (GO:0032495)2.46904550
70lipopolysaccharide-mediated signaling pathway (GO:0031663)2.46413897
71regulation of macrophage cytokine production (GO:0010935)2.46271581
72negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.45775337
73negative regulation of T-helper cell differentiation (GO:0045623)2.45775337
74positive regulation of tolerance induction (GO:0002645)2.45303591
75leukocyte degranulation (GO:0043299)2.45202936
76negative regulation of innate immune response (GO:0045824)2.45133330
77desmosome organization (GO:0002934)2.44672519
78positive regulation of type 2 immune response (GO:0002830)2.42042124
79positive regulation of myeloid leukocyte mediated immunity (GO:0002888)2.39773680
80regulation of dendritic cell antigen processing and presentation (GO:0002604)2.39755121
81myeloid leukocyte activation (GO:0002274)2.38251425
82glomerular visceral epithelial cell development (GO:0072015)2.35997839
83cellular potassium ion homeostasis (GO:0030007)2.32729388
84adhesion of symbiont to host (GO:0044406)2.30647460
85regulation of beta-amyloid formation (GO:1902003)2.30197008
86regulation of amyloid precursor protein catabolic process (GO:1902991)2.26876750
87positive regulation of antigen processing and presentation (GO:0002579)2.22753558
88microglial cell activation (GO:0001774)2.17316599
89sodium ion export (GO:0071436)2.17302488
90negative regulation of erythrocyte differentiation (GO:0045647)2.16338685
91cellular copper ion homeostasis (GO:0006878)2.13986984
92glomerular epithelial cell development (GO:0072310)2.13055280
93positive regulation of mitochondrial calcium ion concentration (GO:0051561)2.12722088
94mannose metabolic process (GO:0006013)2.06845156
95regulation of interferon-beta biosynthetic process (GO:0045357)2.06731163
96regulation of natural killer cell differentiation (GO:0032823)2.06247984
97valine metabolic process (GO:0006573)2.01497399
98neutrophil activation involved in immune response (GO:0002283)1.99630036
99protein localization to endosome (GO:0036010)1.96142585
100apoptotic cell clearance (GO:0043277)1.94520417
101positive regulation of natural killer cell differentiation (GO:0032825)1.94083008
102alpha-linolenic acid metabolic process (GO:0036109)1.94033338
103surfactant homeostasis (GO:0043129)1.92192118
104angiotensin maturation (GO:0002003)1.91441238
105fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)1.91362238
106amyloid precursor protein catabolic process (GO:0042987)1.89518000
107toxin transport (GO:1901998)1.89032827
108peptidyl-glutamic acid carboxylation (GO:0017187)1.85962665
109protein carboxylation (GO:0018214)1.85962665
110Golgi transport vesicle coating (GO:0048200)1.84814683
111COPI coating of Golgi vesicle (GO:0048205)1.84814683
112sulfur amino acid catabolic process (GO:0000098)1.84452342
113regulation of cellular amide metabolic process (GO:0034248)1.84158934
114potassium ion import (GO:0010107)1.84137790
115cellular sodium ion homeostasis (GO:0006883)1.81572197
116very long-chain fatty acid metabolic process (GO:0000038)1.81439596
117keratan sulfate catabolic process (GO:0042340)1.81433779
118positive regulation by symbiont of host defense response (GO:0052509)1.81324373
119modulation by symbiont of host defense response (GO:0052031)1.81324373
120modulation by organism of immune response of other organism involved in symbiotic interaction (GO:001.81324373
121modulation by organism of defense response of other organism involved in symbiotic interaction (GO:01.81324373
122positive regulation by organism of defense response of other organism involved in symbiotic interact1.81324373
123modulation by symbiont of host immune response (GO:0052553)1.81324373
124response to type I interferon (GO:0034340)1.80641673
125response to interferon-alpha (GO:0035455)1.80106571
126regulation of cholesterol biosynthetic process (GO:0045540)1.79726207
127copper ion homeostasis (GO:0055070)1.79295192
128type I interferon signaling pathway (GO:0060337)1.78614159
129cellular response to type I interferon (GO:0071357)1.78614159
130positive regulation of cellular amide metabolic process (GO:0034250)1.78464096
131regulation of antigen processing and presentation (GO:0002577)1.77615839
132complement activation, alternative pathway (GO:0006957)1.77471402
133macrophage activation involved in immune response (GO:0002281)1.76692799
134positive regulation of sterol transport (GO:0032373)1.76102810
135positive regulation of cholesterol transport (GO:0032376)1.76102810
136phospholipid efflux (GO:0033700)1.74799398
137positive regulation of vesicle fusion (GO:0031340)1.74072289
138signal peptide processing (GO:0006465)1.73872059
139peptide catabolic process (GO:0043171)1.73791791
140L-phenylalanine catabolic process (GO:0006559)1.73645577
141erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)1.73645577
142glomerular basement membrane development (GO:0032836)1.73568450
143drug transmembrane transport (GO:0006855)1.73200383
144beta-amyloid metabolic process (GO:0050435)1.70980143
145regulation of ER to Golgi vesicle-mediated transport (GO:0060628)1.70638014
146respiratory burst (GO:0045730)1.70080965
147sphingosine metabolic process (GO:0006670)1.69450393
148positive regulation of p38MAPK cascade (GO:1900745)1.68812655
149negative regulation of protein autophosphorylation (GO:0031953)1.68310142
150detection of other organism (GO:0098543)1.68073584
151production of molecular mediator involved in inflammatory response (GO:0002532)1.67682058
152negative regulation of macrophage derived foam cell differentiation (GO:0010745)1.66721103
153gland morphogenesis (GO:0022612)1.66534513
154growth hormone receptor signaling pathway (GO:0060396)1.66203143
155negative regulation of type 2 immune response (GO:0002829)1.66129192
156regulation of macrophage chemotaxis (GO:0010758)1.65920466
157glutathione biosynthetic process (GO:0006750)1.65323766
158cellular response to thyroid hormone stimulus (GO:0097067)1.65097188
159positive regulation of cholesterol efflux (GO:0010875)1.64856942
160peptide hormone processing (GO:0016486)1.64243633
161regulation of B cell receptor signaling pathway (GO:0050855)1.64167257
162nonribosomal peptide biosynthetic process (GO:0019184)1.63261040
163negative regulation of response to reactive oxygen species (GO:1901032)1.63245226
164sphingoid metabolic process (GO:0046519)1.62782925
165erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)1.62661474
166L-phenylalanine metabolic process (GO:0006558)1.62661474
167positive regulation of phagocytosis (GO:0050766)1.62591569
168potassium ion homeostasis (GO:0055075)1.62406022
169positive regulation of macrophage cytokine production (GO:0060907)1.62170570
170positive regulation of lamellipodium assembly (GO:0010592)1.62017358
171fatty acid beta-oxidation (GO:0006635)1.61925407

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human3.11835370
2ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.49662560
3IRF8_22096565_ChIP-ChIP_GC-B_Human2.39345197
4PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.37995967
5GATA1_22025678_ChIP-Seq_K562_Human2.26818448
6SMAD_19615063_ChIP-ChIP_OVARY_Human2.05829031
7* RXR_22158963_ChIP-Seq_LIVER_Mouse1.93485107
8TRIM28_21343339_ChIP-Seq_HEK293_Human1.88992946
9THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.83517922
10FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.79184928
11STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.75047139
12SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.72666274
13VDR_24763502_ChIP-Seq_THP-1_Human1.70248341
14* LXR_22158963_ChIP-Seq_LIVER_Mouse1.70054128
15BP1_19119308_ChIP-ChIP_Hs578T_Human1.68751725
16ESR2_21235772_ChIP-Seq_MCF-7_Human1.68022384
17IRF8_27001747_Chip-Seq_BMDM_Mouse1.66807990
18TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.65968453
19ESR1_21235772_ChIP-Seq_MCF-7_Human1.63044103
20* PPARA_22158963_ChIP-Seq_LIVER_Mouse1.62687737
21IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.60981293
22RUNX1_22412390_ChIP-Seq_EML_Mouse1.60208916
23IRF8_21731497_ChIP-ChIP_J774_Mouse1.59950270
24CLOCK_20551151_ChIP-Seq_293T_Human1.59401410
25IKZF1_21737484_ChIP-ChIP_HCT116_Human1.57239562
26* Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.54008346
27* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.52612878
28GATA2_21666600_ChIP-Seq_HMVEC_Human1.52445693
29RARG_19884340_ChIP-ChIP_MEFs_Mouse1.50968500
30* SPI1_23547873_ChIP-Seq_NB4_Human1.50757030
31SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.49597371
32CDX2_19796622_ChIP-Seq_MESCs_Mouse1.44071892
33RUNX_20019798_ChIP-Seq_JUKART_Human1.43021143
34NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.42315105
35* MYB_26560356_Chip-Seq_TH2_Human1.42157844
36MTF2_20144788_ChIP-Seq_MESCs_Mouse1.40117546
37SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.39950749
38SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.37788910
39MAF_26560356_Chip-Seq_TH1_Human1.37633832
40STAT4_19710469_ChIP-ChIP_TH1__Mouse1.37362910
41SOX2_20726797_ChIP-Seq_SW620_Human1.37098014
42TCF7_22412390_ChIP-Seq_EML_Mouse1.34115251
43STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.33793674
44SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.31822498
45MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.31038279
46MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.30766308
47SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.27207508
48PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.25824252
49GATA3_27048872_Chip-Seq_THYMUS_Human1.25378455
50P63_26484246_Chip-Seq_KERATINOCYTES_Human1.25251651
51LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.24935588
52SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.24256952
53UTX_26944678_Chip-Seq_JUKART_Human1.23125742
54KDM2B_26808549_Chip-Seq_DND41_Human1.21910819
55CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.21248097
56VDR_21846776_ChIP-Seq_THP-1_Human1.20905512
57LXR_22292898_ChIP-Seq_THP-1_Human1.20164339
58* TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.20013840
59RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.19957653
60MYB_21317192_ChIP-Seq_ERMYB_Mouse1.19812634
61MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.19443013
62GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.19012188
63* FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.18611079
64BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.17951474
65ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.16676697
66SCL_19346495_ChIP-Seq_HPC-7_Human1.16544703
67TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.13791076
68NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.13529551
69NRF2_20460467_ChIP-Seq_MEFs_Mouse1.13529551
70RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.13212480
71GATA1_19941826_ChIP-Seq_K562_Human1.12530854
72SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.11321219
73SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.10929537
74GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.10464658
75MYB_26560356_Chip-Seq_TH1_Human1.10390020
76* FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.09833001
77EZH2_18974828_ChIP-Seq_MESCs_Mouse1.09146496
78RNF2_18974828_ChIP-Seq_MESCs_Mouse1.09146496
79SUZ12_27294783_Chip-Seq_ESCs_Mouse1.08607149
80TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.08106619
81JARID2_20075857_ChIP-Seq_MESCs_Mouse1.05708495
82TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.05499154
83FOXO3_23340844_ChIP-Seq_DLD1_Human1.04908506
84PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.04191037
85ZNF217_24962896_ChIP-Seq_MCF-7_Human1.03791652
86* STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.03039581
87PU_27001747_Chip-Seq_BMDM_Mouse1.02895447
88PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.99555133
89KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.98785858
90ESR1_20079471_ChIP-ChIP_T-47D_Human0.98394213
91SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.98219631
92TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.97608605
93GATA2_19941826_ChIP-Seq_K562_Human0.96673285
94EZH2_27294783_Chip-Seq_ESCs_Mouse0.96578610
95DROSHA_22980978_ChIP-Seq_HELA_Human0.96225382
96* SOX9_24532713_ChIP-Seq_HFSC_Mouse0.95330238
97ELK3_25401928_ChIP-Seq_HUVEC_Human0.95236636
98CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.95126781
99DNAJC2_21179169_ChIP-ChIP_NT2_Human0.94442353
100EED_16625203_ChIP-ChIP_MESCs_Mouse0.94095241
101CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.93141231
102GATA2_22383799_ChIP-Seq_G1ME_Mouse0.92925905
103VDR_24787735_ChIP-Seq_THP-1_Human0.92655242
104SPI1_23127762_ChIP-Seq_K562_Human0.92430641
105* CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.92146616
106CJUN_26792858_Chip-Seq_BT549_Human0.91683429
107EGR1_19032775_ChIP-ChIP_M12_Human0.91194726
108KDM2B_26808549_Chip-Seq_SUP-B15_Human0.90843119
109CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.90465728
110NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.89516465
111* PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.89334998
112IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.89036759
113GATA3_26560356_Chip-Seq_TH2_Human0.88908923
114GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.88304814
115KDM2B_26808549_Chip-Seq_JURKAT_Human0.88260833
116KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.88134975
117EGR1_19374776_ChIP-ChIP_THP-1_Human0.87217653
118NR3C1_23031785_ChIP-Seq_PC12_Mouse0.87100082
119PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.86958503
120MAF_26560356_Chip-Seq_TH2_Human0.86588510
121CDX2_20551321_ChIP-Seq_CACO-2_Human0.84883790
122ERG_21242973_ChIP-ChIP_JURKAT_Human0.84342015
123JARID2_20064375_ChIP-Seq_MESCs_Mouse0.84228394
124PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.83570283
125* SOX2_27498859_Chip-Seq_STOMACH_Mouse0.83056345
126* BRD4_27068464_Chip-Seq_AML-cells_Mouse0.82905540
127BCAT_22108803_ChIP-Seq_LS180_Human0.82604551
128KDM2B_26808549_Chip-Seq_K562_Human0.82489352
129* TP63_23658742_ChIP-Seq_EP156T_Human0.81621022
130* GATA1_22383799_ChIP-Seq_G1ME_Mouse0.81278884
131LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.81239256
132RXR_22108803_ChIP-Seq_LS180_Human0.81201212
133VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.80521785
134GATA1_19941827_ChIP-Seq_MEL_Mouse0.80058065
135SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.79811979
136CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.79219982
137E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.78241920
138NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.78189372
139VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.77497405
140TP53_18474530_ChIP-ChIP_U2OS_Human0.76370315
141GATA1_19941827_ChIP-Seq_MEL86_Mouse0.76139733
142AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.75821909
143NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.72060986

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005058_abnormal_lysosome_morphology3.26236820
2MP0002254_reproductive_system_inflammat2.65688811
3MP0003191_abnormal_cellular_cholesterol2.60030725
4MP0003724_increased_susceptibility_to2.43914844
5MP0001800_abnormal_humoral_immune2.16392588
6MP0003300_gastrointestinal_ulcer2.12598660
7MP0003075_altered_response_to2.06362531
8MP0003183_abnormal_peptide_metabolism2.04976817
9MP0010234_abnormal_vibrissa_follicle2.03254338
10MP0009840_abnormal_foam_cell1.95618017
11MP0003828_pulmonary_edema1.88642775
12MP0001835_abnormal_antigen_presentation1.88576498
13MP0003690_abnormal_glial_cell1.83924969
14MP0000604_amyloidosis1.82341709
15MP0008260_abnormal_autophagy1.78176345
16MP0003329_amyloid_beta_deposits1.76387462
17MP0000013_abnormal_adipose_tissue1.75171172
18MP0003195_calcinosis1.72483857
19MP0005275_abnormal_skin_tensile1.70941996
20MP0002909_abnormal_adrenal_gland1.69870878
21MP0003172_abnormal_lysosome_physiology1.68329396
22MP0000685_abnormal_immune_system1.64883473
23MP0003436_decreased_susceptibility_to1.63336544
24MP0002796_impaired_skin_barrier1.62506574
25MP0005167_abnormal_blood-brain_barrier1.61904286
26MP0002405_respiratory_system_inflammati1.59072791
27MP0002166_altered_tumor_susceptibility1.57414188
28MP0009785_altered_susceptibility_to1.55754023
29MP0006082_CNS_inflammation1.53509520
30MP0002419_abnormal_innate_immunity1.53372450
31MP0003763_abnormal_thymus_physiology1.51312168
32MP0009643_abnormal_urine_homeostasis1.50257594
33MP0008875_abnormal_xenobiotic_pharmacok1.47061839
34MP0008004_abnormal_stomach_pH1.44979870
35MP0004883_abnormal_blood_vessel1.44861336
36MP0002148_abnormal_hypersensitivity_rea1.44180338
37MP0001533_abnormal_skeleton_physiology1.44126387
38MP0001765_abnormal_ion_homeostasis1.42130036
39MP0004947_skin_inflammation1.41223910
40MP0010386_abnormal_urinary_bladder1.38748630
41MP0003303_peritoneal_inflammation1.38006055
42MP0005025_abnormal_response_to1.37115569
43MP0005464_abnormal_platelet_physiology1.35193957
44MP0005360_urolithiasis1.33858951
45MP0002132_abnormal_respiratory_system1.33791830
46MP0000716_abnormal_immune_system1.31556424
47MP0001790_abnormal_immune_system1.30663641
48MP0005387_immune_system_phenotype1.30663641
49MP0001851_eye_inflammation1.30472133
50MP0010329_abnormal_lipoprotein_level1.27968900
51MP0005332_abnormal_amino_acid1.25184335
52MP0000858_altered_metastatic_potential1.24000904
53MP0009278_abnormal_bone_marrow1.23527430
54MP0005671_abnormal_response_to1.23341267
55MP0005000_abnormal_immune_tolerance1.21687163
56MP0001958_emphysema1.21390295
57MP0002277_abnormal_respiratory_mucosa1.20145866
58MP0005365_abnormal_bile_salt1.20140724
59MP0002139_abnormal_hepatobiliary_system1.19923643
60MP0002398_abnormal_bone_marrow1.18862900
61MP0000920_abnormal_myelination1.18704095
62MP0002138_abnormal_hepatobiliary_system1.18543483
63MP0003638_abnormal_response/metabolism_1.18334510
64MP0000343_altered_response_to1.17247969
65MP0008469_abnormal_protein_level1.15893610
66MP0008438_abnormal_cutaneous_collagen1.15290663
67MP0000465_gastrointestinal_hemorrhage1.15141107
68MP0004019_abnormal_vitamin_homeostasis1.14463419
69MP0009764_decreased_sensitivity_to1.13685792
70MP0005166_decreased_susceptibility_to1.11026204
71MP0004858_abnormal_nervous_system1.10395395
72MP0001756_abnormal_urination1.09851467
73MP0005584_abnormal_enzyme/coenzyme_acti1.09233923
74MP0004043_abnormal_pH_regulation1.07712266
75MP0001845_abnormal_inflammatory_respons1.06883785
76MP0005165_increased_susceptibility_to1.05659685
77MP0002136_abnormal_kidney_physiology1.05172500
78MP0004130_abnormal_muscle_cell1.03102063
79MP0010368_abnormal_lymphatic_system1.02767877
80MP0000230_abnormal_systemic_arterial1.02559221
81MP0001873_stomach_inflammation1.02424012
82MP0002118_abnormal_lipid_homeostasis1.01505387
83MP0005310_abnormal_salivary_gland1.01086170
84MP0002933_joint_inflammation1.00015232
85MP0002998_abnormal_bone_remodeling0.99967600
86MP0004381_abnormal_hair_follicle0.99228875
87MP0002006_tumorigenesis0.99190722
88MP0009333_abnormal_splenocyte_physiolog0.99027424
89MP0005636_abnormal_mineral_homeostasis0.99013113
90MP0001879_abnormal_lymphatic_vessel0.98128063
91MP0004484_altered_response_of0.97713697
92MP0003879_abnormal_hair_cell0.97347352
93MP0008874_decreased_physiological_sensi0.96712218
94MP0002722_abnormal_immune_system0.96046348
95MP0006054_spinal_hemorrhage0.95692387
96MP0003045_fibrosis0.95671002
97MP0000689_abnormal_spleen_morphology0.95414734
98MP0002060_abnormal_skin_morphology0.95050406
99MP0005397_hematopoietic_system_phenotyp0.94251229
100MP0001545_abnormal_hematopoietic_system0.94251229
101MP0002723_abnormal_immune_serum0.94042438
102MP0002429_abnormal_blood_cell0.93184913
103MP0009384_cardiac_valve_regurgitation0.93055547
104MP0003448_altered_tumor_morphology0.91938194
105MP0002090_abnormal_vision0.90686236
106MP0005390_skeleton_phenotype0.89402222
107MP0000249_abnormal_blood_vessel0.88676437
108* MP0003633_abnormal_nervous_system0.87656952
109MP0005535_abnormal_body_temperature0.87240048
110MP0002452_abnormal_antigen_presenting0.86355195
111MP0009763_increased_sensitivity_to0.86304029
112MP0010155_abnormal_intestine_physiology0.86239321
113MP0002295_abnormal_pulmonary_circulatio0.85890396
114MP0002009_preneoplasia0.85099982
115MP0005388_respiratory_system_phenotype0.84891906
116MP0002133_abnormal_respiratory_system0.84891906
117MP0001853_heart_inflammation0.84396682
118MP0004272_abnormal_basement_membrane0.84209326
119MP0005164_abnormal_response_to0.84134905
120MP0004510_myositis0.83809570
121MP0003252_abnormal_bile_duct0.83606560
122MP0004147_increased_porphyrin_level0.81460658
123MP0003453_abnormal_keratinocyte_physiol0.80919636
124MP0002420_abnormal_adaptive_immunity0.80275260
125MP0001819_abnormal_immune_cell0.80034894
126MP0003866_abnormal_defecation0.79887068
127MP0009780_abnormal_chondrocyte_physiolo0.79299164
128MP0005409_darkened_coat_color0.77909030
129MP0001501_abnormal_sleep_pattern0.77873296
130MP0005083_abnormal_biliary_tract0.76200444
131MP0003279_aneurysm0.76099957
132MP0005451_abnormal_body_composition0.76011898
133MP0003091_abnormal_cell_migration0.75958985
134MP0000703_abnormal_thymus_morphology0.71701566
135MP0003795_abnormal_bone_structure0.69629677
136MP0001663_abnormal_digestive_system0.69351311
137MP0002971_abnormal_brown_adipose0.66037432
138MP0008569_lethality_at_weaning0.62234415
139MP0003656_abnormal_erythrocyte_physiolo0.57413810

Predicted human phenotypes

RankGene SetZ-score
1Orchitis (HP:0100796)4.75525907
2Vacuolated lymphocytes (HP:0001922)4.64427656
3Dysostosis multiplex (HP:0000943)4.46148139
4Retrobulbar optic neuritis (HP:0100654)4.32529535
5Optic neuritis (HP:0100653)4.32529535
6Stomatitis (HP:0010280)3.96691283
7Systemic lupus erythematosus (HP:0002725)3.79313820
8Increased cerebral lipofuscin (HP:0011813)3.72423379
9Urinary glycosaminoglycan excretion (HP:0003541)3.58675213
10Mucopolysacchariduria (HP:0008155)3.58675213
11Neurofibrillary tangles (HP:0002185)3.53964045
12Glomerulonephritis (HP:0000099)3.38696458
13Gastrointestinal infarctions (HP:0005244)3.33906002
14Prolonged bleeding time (HP:0003010)3.31228675
15Increased neuronal autofluorescent lipopigment (HP:0002074)3.29970134
16Mediastinal lymphadenopathy (HP:0100721)3.29835234
17Abnormality of polysaccharide metabolism (HP:0011012)3.28876832
18Abnormality of glycosaminoglycan metabolism (HP:0004371)3.28876832
19Abnormality of mucopolysaccharide metabolism (HP:0011020)3.28876832
20Keratoconjunctivitis sicca (HP:0001097)3.27918672
21Complement deficiency (HP:0004431)3.18133355
22Gingivitis (HP:0000230)3.15786866
23Gingival bleeding (HP:0000225)3.13293058
24Eczematoid dermatitis (HP:0000976)3.11924049
25Chronic obstructive pulmonary disease (HP:0006510)3.09589101
26Obstructive lung disease (HP:0006536)3.09589101
27Keratoconjunctivitis (HP:0001096)3.02159911
28Recurrent fungal infections (HP:0002841)3.00811488
29Abnormality of glycolipid metabolism (HP:0010969)2.91370544
30Abnormality of liposaccharide metabolism (HP:0010968)2.91370544
31Abnormality of glycosphingolipid metabolism (HP:0004343)2.91370544
32Episodic fever (HP:0001954)2.90820749
33Meningitis (HP:0001287)2.89863502
34Amyloidosis (HP:0011034)2.88509811
35Urticaria (HP:0001025)2.84734064
36Vasculitis (HP:0002633)2.82783458
37Hyperactive renin-angiotensin system (HP:0000841)2.73591374
38Encephalitis (HP:0002383)2.73245860
39Epistaxis (HP:0000421)2.70135887
40Nephritis (HP:0000123)2.68202211
41Loss of speech (HP:0002371)2.68010524
42Abnormality of macrophages (HP:0004311)2.67457899
43Cerebral inclusion bodies (HP:0100314)2.67240298
44Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.65175840
45Hypokalemic alkalosis (HP:0001949)2.61552688
46Abnormal delayed hypersensitivity skin test (HP:0002963)2.59949036
47Peritonitis (HP:0002586)2.56764521
48Pulmonary infiltrates (HP:0002113)2.56028573
49Petechiae (HP:0000967)2.55798368
50Chest pain (HP:0100749)2.55194079
51Interstitial pulmonary disease (HP:0006530)2.55085767
52Pulmonary embolism (HP:0002204)2.52995748
53Chronic otitis media (HP:0000389)2.51895187
54Hemoptysis (HP:0002105)2.51851909
55Recurrent gram-negative bacterial infections (HP:0005420)2.51029889
56T lymphocytopenia (HP:0005403)2.50898387
57Hypochromic microcytic anemia (HP:0004840)2.50496400
58Recurrent abscess formation (HP:0002722)2.48728995
59Axonal loss (HP:0003447)2.48722671
60Cellulitis (HP:0100658)2.44046773
61Abnormality of complement system (HP:0005339)2.42022517
62Xanthomatosis (HP:0000991)2.41398059
63Abnormality of T cell number (HP:0011839)2.38689424
64Abnormality of the nasal mucosa (HP:0000433)2.35331117
65Recurrent cutaneous fungal infections (HP:0011370)2.34841690
66Chronic mucocutaneous candidiasis (HP:0002728)2.34841690
67Arterial thrombosis (HP:0004420)2.31615184
68Hematochezia (HP:0002573)2.30350930
69Abnormality of aromatic amino acid family metabolism (HP:0004338)2.29948964
70Increased circulating renin level (HP:0000848)2.28858748
71Recurrent bacterial skin infections (HP:0005406)2.27694781
72Arterial tortuosity (HP:0005116)2.27217533
73Spontaneous hematomas (HP:0007420)2.27050582
74Supranuclear gaze palsy (HP:0000605)2.26988976
75Papilledema (HP:0001085)2.25129690
76Ketoacidosis (HP:0001993)2.24001281
77Metabolic alkalosis (HP:0200114)2.22449867
78Vascular tortuosity (HP:0004948)2.15595620
79Abnormality of binocular vision (HP:0011514)2.15488788
80Diplopia (HP:0000651)2.15488788
81Leukocytosis (HP:0001974)2.15099508
82Pustule (HP:0200039)2.15025004
83Inflammation of the large intestine (HP:0002037)2.14910541
84Retinal atrophy (HP:0001105)2.14275148
85Elevated erythrocyte sedimentation rate (HP:0003565)2.13217105
86Abnormal platelet volume (HP:0011876)2.08841593
87Abnormality of chloride homeostasis (HP:0011422)2.06041812
88Mesangial abnormality (HP:0001966)2.05840484
89Gangrene (HP:0100758)2.05776501
90Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.05146780
91Hypochromic anemia (HP:0001931)2.04721780
92Hypergammaglobulinemia (HP:0010702)2.04559110
93Osteomyelitis (HP:0002754)2.04095225
94Vertigo (HP:0002321)2.03378599
95Gastrointestinal inflammation (HP:0004386)2.02704754
96Abnormality of renin-angiotensin system (HP:0000847)2.01927453
97Cardiomegaly (HP:0001640)2.01863800
98Acne (HP:0001061)2.01827255
99Hypoglycemic seizures (HP:0002173)2.01280092
100Hyperlipoproteinemia (HP:0010980)2.00968982
101Ventricular fibrillation (HP:0001663)1.99761597
102Myositis (HP:0100614)1.99441163
103Growth hormone excess (HP:0000845)1.98114147
104Joint swelling (HP:0001386)1.98047935
105Anorexia (HP:0002039)1.95218363
106Premature loss of primary teeth (HP:0006323)1.94313446
107Increased IgE level (HP:0003212)1.93553619
108Hyperaldosteronism (HP:0000859)1.93224357
109Ketosis (HP:0001946)1.92459590
110Abnormality of the pleura (HP:0002103)1.91872587
111Hemiplegia (HP:0002301)1.91287729
112Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.90812652
113Abnormality of the peritoneum (HP:0002585)1.90114098
114Hepatosplenomegaly (HP:0001433)1.89940739
115Microcytic anemia (HP:0001935)1.89770539
116Erythema (HP:0010783)1.85913110
117Increased CSF protein (HP:0002922)1.84951972
118Malnutrition (HP:0004395)1.84605191
119Broad metatarsal (HP:0001783)1.83075876
120Slow saccadic eye movements (HP:0000514)1.82966314
121Abnormality of T cells (HP:0002843)1.82455386
122Beaking of vertebral bodies (HP:0004568)1.81889520
123Right ventricular cardiomyopathy (HP:0011663)1.80744378
124Sepsis (HP:0100806)1.80609621
125Focal segmental glomerulosclerosis (HP:0000097)1.80420581
126Increased IgM level (HP:0003496)1.79736583
127Abnormality of secondary sexual hair (HP:0009888)1.77922319
128Abnormality of the axillary hair (HP:0100134)1.77922319
129Glomerulopathy (HP:0100820)1.77658326
130* Progressive neurologic deterioration (HP:0002344)1.77131125
131Nasal polyposis (HP:0100582)1.75945992
132Onycholysis (HP:0001806)1.75468234
133Recurrent skin infections (HP:0001581)1.75260835
134Recurrent bronchitis (HP:0002837)1.75105554
135Disinhibition (HP:0000734)1.75053642
136Purpura (HP:0000979)1.74788577
137Myocardial infarction (HP:0001658)1.73933767
138Hypoglycemic coma (HP:0001325)1.72838767
139Abnormality of the lumbar spine (HP:0100712)1.72715590
140Asymmetric septal hypertrophy (HP:0001670)1.72236624
141Polygenic inheritance (HP:0010982)1.72030245
142Symptomatic seizures (HP:0011145)1.69733387
143Alkalosis (HP:0001948)1.69668714
144Cerebral hemorrhage (HP:0001342)1.69614442
145Abnormality of the common coagulation pathway (HP:0010990)1.69049857
146Colitis (HP:0002583)1.68416664
147Generalized aminoaciduria (HP:0002909)1.67874138
148Hydroxyprolinuria (HP:0003080)1.66775580
149Abnormality of proline metabolism (HP:0010907)1.66775580
150Deep venous thrombosis (HP:0002625)1.65091723
151Decreased circulating renin level (HP:0003351)1.64584864
152Hypomagnesemia (HP:0002917)1.63812071
153Progressive visual loss (HP:0000529)1.63444651
154Sensorimotor neuropathy (HP:0007141)1.63247193
155Abnormality of fatty-acid metabolism (HP:0004359)1.62819026
156Abnormality of magnesium homeostasis (HP:0004921)1.62811399
157Late onset (HP:0003584)1.62474628
158Protuberant abdomen (HP:0001538)1.61836315
159Adrenal overactivity (HP:0002717)1.61023345
160Retinal dysplasia (HP:0007973)1.59645424
161Glomerulosclerosis (HP:0000096)1.57939856
162Abnormal urine output (HP:0012590)1.57781966
163Polycythemia (HP:0001901)1.57248429
164Type II lissencephaly (HP:0007260)1.56772937
165Neuronal loss in central nervous system (HP:0002529)1.56364552
166Joint stiffness (HP:0001387)1.55354162

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ERN12.87298316
2TGFBR22.85758395
3MAPK152.72702474
4EPHB12.25992304
5RIPK42.25443828
6KIT1.95730968
7PRPF4B1.94462521
8GRK61.90997392
9BCKDK1.74948803
10BLK1.73158435
11RIPK11.70754859
12TIE11.65839405
13CAMKK21.64443343
14TBK11.63039300
15KDR1.62321281
16TRIB31.60587727
17MAP3K121.59483274
18TYK21.58646035
19MAP3K21.55358061
20MAPKAPK31.53742989
21FGFR41.52428678
22MAP3K131.48505728
23TAOK11.47740505
24WNK41.44339077
25FGR1.44241022
26MYLK1.40688523
27ZAP701.40224087
28JAK11.39824029
29OXSR11.38955272
30MAPKAPK51.38161914
31TAOK31.36476056
32MAP3K111.36245614
33PIK3CG1.35677505
34LMTK21.32917454
35SIK11.28338405
36IKBKE1.21804389
37EPHA31.21738338
38FER1.16228996
39PTK61.15782066
40YES11.15063497
41BTK1.12216044
42MST1R1.11956276
43MAP3K11.11252038
44LYN1.08636108
45MST41.08302868
46BMPR21.08175217
47KSR21.05747303
48INSRR1.05744498
49FES1.05115088
50NTRK11.04541346
51LRRK21.03900121
52ARAF1.02003201
53MARK20.99463264
54TEC0.99239097
55MAP4K10.98895860
56STK390.98658681
57FLT30.95764877
58JAK20.94870481
59ITK0.92825757
60WNK30.92624232
61MAP3K30.92498348
62GRK70.90853764
63MAP3K60.90730017
64JAK30.90690825
65MAP2K30.88726292
66CSF1R0.88637987
67SIK30.87366903
68FRK0.87113378
69MATK0.84389131
70STK380.82799996
71CSK0.80746021
72IRAK40.79545934
73TRPM70.77433912
74PRKD20.76962378
75SYK0.75991143
76PRKCH0.75544297
77SGK30.72951011
78HIPK20.72523408
79NLK0.72042742
80MAPK70.71911535
81CDK190.70956715
82CDC42BPA0.70500127
83CAMKK10.69060088
84MAP3K140.68852498
85IRAK30.68357569
86PTK20.68258484
87SGK20.67852697
88MOS0.65957433
89FGFR30.63075086
90IRAK20.63035687
91TNK20.61819328
92HCK0.61679347
93MAP2K60.61082205
94TAOK20.59016420
95MAP2K40.58928777
96LCK0.58918846
97CAMK1D0.57590438
98PDPK10.57165946
99RET0.56979569
100STK110.56224004
101SCYL20.54753956
102GRK50.54423336
103MAP2K20.54276274
104IRAK10.53607832
105SGK2230.53431153
106SGK4940.53431153
107NTRK30.53177145
108PRKG20.52870254
109MAP3K90.52103298
110RAF10.51917769
111EPHA40.51407325
112ACVR1B0.51021162
113KSR10.50616398
114FYN0.50615867
115MAP3K50.49849053
116DAPK20.49650909
117PDK10.48707122
118MAP3K70.48131282
119CAMK1G0.47866532
120PAK40.47780338
121TXK0.47046949
122PRKD10.46533196
123PRKCQ0.46320689
124IGF1R0.46128734
125MAPK120.45547113
126PTK2B0.45339598
127DMPK0.45338145
128CAMK2G0.44664253
129TGFBR10.44372608
130MARK30.43908295
131IKBKB0.43753356
132CAMK10.42871369
133TESK10.42514107
134DYRK1B0.42329649
135TESK20.39844465
136BMX0.37363226
137PAK60.37262887

Predicted pathways (KEGG)

RankGene SetZ-score
1Other glycan degradation_Homo sapiens_hsa005112.27471196
2Lysosome_Homo sapiens_hsa041422.26317193
3Staphylococcus aureus infection_Homo sapiens_hsa051502.08984541
4Nitrogen metabolism_Homo sapiens_hsa009101.99300853
5Glycosaminoglycan degradation_Homo sapiens_hsa005311.97521704
6Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.81467965
7Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.76762504
8Graft-versus-host disease_Homo sapiens_hsa053321.75533011
9Allograft rejection_Homo sapiens_hsa053301.73779939
10Autoimmune thyroid disease_Homo sapiens_hsa053201.64004083
11Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.59128938
12Caffeine metabolism_Homo sapiens_hsa002321.53286705
13Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.45998178
14Type I diabetes mellitus_Homo sapiens_hsa049401.44061198
15Sulfur metabolism_Homo sapiens_hsa009201.38179683
16Fatty acid degradation_Homo sapiens_hsa000711.29608504
17Complement and coagulation cascades_Homo sapiens_hsa046101.26343037
18NOD-like receptor signaling pathway_Homo sapiens_hsa046211.26202187
19Hematopoietic cell lineage_Homo sapiens_hsa046401.25675067
20T cell receptor signaling pathway_Homo sapiens_hsa046601.20780933
21Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.20123375
22Histidine metabolism_Homo sapiens_hsa003401.18323691
23ABC transporters_Homo sapiens_hsa020101.15616534
24Primary bile acid biosynthesis_Homo sapiens_hsa001201.14069270
25PPAR signaling pathway_Homo sapiens_hsa033201.13654221
26Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.13580275
27Primary immunodeficiency_Homo sapiens_hsa053401.13304022
28Sphingolipid metabolism_Homo sapiens_hsa006001.11778128
29Pertussis_Homo sapiens_hsa051331.09728780
30Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.09292010
31Acute myeloid leukemia_Homo sapiens_hsa052211.08134767
32Measles_Homo sapiens_hsa051621.06087024
33Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.03677709
34Leishmaniasis_Homo sapiens_hsa051401.02934551
35Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.02575200
36Viral myocarditis_Homo sapiens_hsa054161.01598273
37Pentose and glucuronate interconversions_Homo sapiens_hsa000401.01429873
38Osteoclast differentiation_Homo sapiens_hsa043801.00443546
39Bile secretion_Homo sapiens_hsa049760.99974734
40Gastric acid secretion_Homo sapiens_hsa049710.98796656
41Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.97839737
42Salivary secretion_Homo sapiens_hsa049700.97479973
43TNF signaling pathway_Homo sapiens_hsa046680.97427667
44Jak-STAT signaling pathway_Homo sapiens_hsa046300.96944102
45NF-kappa B signaling pathway_Homo sapiens_hsa040640.96497336
46Collecting duct acid secretion_Homo sapiens_hsa049660.96422434
47Fatty acid elongation_Homo sapiens_hsa000620.96231044
48Legionellosis_Homo sapiens_hsa051340.96037284
49Renin secretion_Homo sapiens_hsa049240.95866579
50Influenza A_Homo sapiens_hsa051640.95704847
51Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.92521238
52Fatty acid metabolism_Homo sapiens_hsa012120.92470775
53Peroxisome_Homo sapiens_hsa041460.91492303
54Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.91264809
55Hepatitis C_Homo sapiens_hsa051600.90983426
56Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.90432691
57Intestinal immune network for IgA production_Homo sapiens_hsa046720.89617331
58Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.89479797
59Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.89277039
60Rheumatoid arthritis_Homo sapiens_hsa053230.86246103
61Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.85508811
62Vibrio cholerae infection_Homo sapiens_hsa051100.84497339
63Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.84038208
64Phospholipase D signaling pathway_Homo sapiens_hsa040720.83943617
65Pancreatic secretion_Homo sapiens_hsa049720.83674498
66Phosphatidylinositol signaling system_Homo sapiens_hsa040700.83064700
67Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.82626914
68Maturity onset diabetes of the young_Homo sapiens_hsa049500.82309773
69Carbohydrate digestion and absorption_Homo sapiens_hsa049730.81646191
70Asthma_Homo sapiens_hsa053100.81278994
71GnRH signaling pathway_Homo sapiens_hsa049120.79636394
72Tuberculosis_Homo sapiens_hsa051520.79457825
73Non-small cell lung cancer_Homo sapiens_hsa052230.79121283
74Mineral absorption_Homo sapiens_hsa049780.78379922
75RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.78003746
76Phagosome_Homo sapiens_hsa041450.78003389
77Dorso-ventral axis formation_Homo sapiens_hsa043200.77888797
78Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.76570393
79Leukocyte transendothelial migration_Homo sapiens_hsa046700.76116935
80Malaria_Homo sapiens_hsa051440.76013134
81Thyroid hormone synthesis_Homo sapiens_hsa049180.75730299
82Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.75084467
83Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.71160085
84Chemical carcinogenesis_Homo sapiens_hsa052040.70215763
85Pancreatic cancer_Homo sapiens_hsa052120.69526286
86Prion diseases_Homo sapiens_hsa050200.68635820
87Choline metabolism in cancer_Homo sapiens_hsa052310.68197807
88Renal cell carcinoma_Homo sapiens_hsa052110.67869828
89Amoebiasis_Homo sapiens_hsa051460.67672397
90Neurotrophin signaling pathway_Homo sapiens_hsa047220.67665383
91Platelet activation_Homo sapiens_hsa046110.67150217
92Adipocytokine signaling pathway_Homo sapiens_hsa049200.67039763
93Propanoate metabolism_Homo sapiens_hsa006400.66354973
94Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.66139328
95Tryptophan metabolism_Homo sapiens_hsa003800.65680416
96Toll-like receptor signaling pathway_Homo sapiens_hsa046200.65560293
97Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.65438480
98Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.65038598
99Insulin secretion_Homo sapiens_hsa049110.64123552
100Shigellosis_Homo sapiens_hsa051310.63952429
101Hepatitis B_Homo sapiens_hsa051610.63074631
102Cyanoamino acid metabolism_Homo sapiens_hsa004600.62734032
103beta-Alanine metabolism_Homo sapiens_hsa004100.62371883
104Herpes simplex infection_Homo sapiens_hsa051680.62236980
105Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.62157957
106Long-term depression_Homo sapiens_hsa047300.61782141
107SNARE interactions in vesicular transport_Homo sapiens_hsa041300.60466942
108Prolactin signaling pathway_Homo sapiens_hsa049170.60375088
109Aldosterone synthesis and secretion_Homo sapiens_hsa049250.59292683
110Renin-angiotensin system_Homo sapiens_hsa046140.58909877
111Sphingolipid signaling pathway_Homo sapiens_hsa040710.58439048
112Glycerophospholipid metabolism_Homo sapiens_hsa005640.57124392
113Starch and sucrose metabolism_Homo sapiens_hsa005000.56944401
114Rap1 signaling pathway_Homo sapiens_hsa040150.55447027
115B cell receptor signaling pathway_Homo sapiens_hsa046620.54906932
116Salmonella infection_Homo sapiens_hsa051320.54183284
117Toxoplasmosis_Homo sapiens_hsa051450.54039648
118Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.53831245
119Protein digestion and absorption_Homo sapiens_hsa049740.53777657
120Circadian entrainment_Homo sapiens_hsa047130.53410491
121Glycerolipid metabolism_Homo sapiens_hsa005610.53127472
122Inositol phosphate metabolism_Homo sapiens_hsa005620.52980786
123Estrogen signaling pathway_Homo sapiens_hsa049150.52715713
124African trypanosomiasis_Homo sapiens_hsa051430.51585561
125ECM-receptor interaction_Homo sapiens_hsa045120.50714482
126FoxO signaling pathway_Homo sapiens_hsa040680.50582938
127Endocytosis_Homo sapiens_hsa041440.50524249
128Type II diabetes mellitus_Homo sapiens_hsa049300.50050869
129Synaptic vesicle cycle_Homo sapiens_hsa047210.49825917
130cAMP signaling pathway_Homo sapiens_hsa040240.49368218
131AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.49191263
132Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.48671867
133Apoptosis_Homo sapiens_hsa042100.48641991
134Chronic myeloid leukemia_Homo sapiens_hsa052200.48532448
135GABAergic synapse_Homo sapiens_hsa047270.47755553
136Vascular smooth muscle contraction_Homo sapiens_hsa042700.47460524
137Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.47415442
138Antigen processing and presentation_Homo sapiens_hsa046120.47095021
139VEGF signaling pathway_Homo sapiens_hsa043700.46782938
140Morphine addiction_Homo sapiens_hsa050320.46512871
141Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.46259518
142Long-term potentiation_Homo sapiens_hsa047200.45274438
143Regulation of autophagy_Homo sapiens_hsa041400.44883172
144Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.44520095
145Taste transduction_Homo sapiens_hsa047420.44178503
146Glutamatergic synapse_Homo sapiens_hsa047240.44123608
147N-Glycan biosynthesis_Homo sapiens_hsa005100.43940178
148Chemokine signaling pathway_Homo sapiens_hsa040620.43290611
149Protein export_Homo sapiens_hsa030600.42860940
150Butanoate metabolism_Homo sapiens_hsa006500.42827003
151Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.42824983
152Arachidonic acid metabolism_Homo sapiens_hsa005900.41908155

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