ITPK1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes an enzyme that belongs to the inositol 1,3,4-trisphosphate 5/6-kinase family. This enzyme regulates the synthesis of inositol tetraphosphate, and downstream products, inositol pentakisphosphate and inositol hexakisphosphate. Inositol metabolism plays a role in the development of the neural tube. Disruptions in this gene are thought to be associated with neural tube defects. A pseudogene of this gene has been identified on chromosome X. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1synaptic vesicle docking involved in exocytosis (GO:0016081)5.18751276
2sodium ion export (GO:0071436)4.95770493
3intestinal epithelial cell development (GO:0060576)4.46364745
4L-amino acid import (GO:0043092)4.44623482
5cellular potassium ion homeostasis (GO:0030007)4.42485061
6axon ensheathment in central nervous system (GO:0032291)4.42044621
7central nervous system myelination (GO:0022010)4.42044621
8potassium ion homeostasis (GO:0055075)4.37691128
9establishment of mitochondrion localization (GO:0051654)4.30748231
10synaptic vesicle maturation (GO:0016188)4.21265418
11angiotensin maturation (GO:0002003)4.02248632
12intestinal absorption (GO:0050892)3.98587003
13negative regulation of amyloid precursor protein catabolic process (GO:1902992)3.96039081
14amino acid import (GO:0043090)3.93342395
15mitochondrion transport along microtubule (GO:0047497)3.84685103
16establishment of mitochondrion localization, microtubule-mediated (GO:0034643)3.84685103
17glycine transport (GO:0015816)3.66072805
18regulation of synaptic vesicle transport (GO:1902803)3.57913784
19positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.53808941
20response to pheromone (GO:0019236)3.53547780
21negative regulation of microtubule polymerization (GO:0031115)3.44091670
22CDP-diacylglycerol biosynthetic process (GO:0016024)3.40815332
23cerebellar granule cell differentiation (GO:0021707)3.40015438
24peptidyl-tyrosine autophosphorylation (GO:0038083)3.39543516
25neurotransmitter secretion (GO:0007269)3.33041654
26negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.32298735
27negative regulation of cell killing (GO:0031342)3.32298735
28CDP-diacylglycerol metabolic process (GO:0046341)3.32230162
29intestinal cholesterol absorption (GO:0030299)3.29568711
30negative regulation of erythrocyte differentiation (GO:0045647)3.29014977
31pentose-phosphate shunt (GO:0006098)3.25946816
32anterior/posterior axis specification, embryo (GO:0008595)3.24920026
33positive regulation of Rap GTPase activity (GO:0032854)3.18205333
34glycerophospholipid catabolic process (GO:0046475)3.15739927
35locomotory exploration behavior (GO:0035641)3.15374356
36cytoskeletal anchoring at plasma membrane (GO:0007016)3.14100372
37regulation of neuronal synaptic plasticity (GO:0048168)3.11797323
38signal complex assembly (GO:0007172)3.11455986
39myelin maintenance (GO:0043217)3.08938687
40cell-cell junction maintenance (GO:0045217)3.08733260
41positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.06948779
42positive regulation by symbiont of host defense response (GO:0052509)3.02083676
43modulation by symbiont of host defense response (GO:0052031)3.02083676
44modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.02083676
45modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.02083676
46positive regulation by organism of defense response of other organism involved in symbiotic interact3.02083676
47modulation by symbiont of host immune response (GO:0052553)3.02083676
48phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)2.99933539
49positive regulation of sodium ion transmembrane transporter activity (GO:2000651)2.96473972
50regulation of short-term neuronal synaptic plasticity (GO:0048172)2.95302532
51positive regulation of synapse maturation (GO:0090129)2.94917556
52actin filament depolymerization (GO:0030042)2.94647973
53virion attachment to host cell (GO:0019062)2.94614973
54adhesion of symbiont to host cell (GO:0044650)2.94614973
55regulation of gene silencing by RNA (GO:0060966)2.93631743
56regulation of posttranscriptional gene silencing (GO:0060147)2.93631743
57regulation of gene silencing by miRNA (GO:0060964)2.93631743
58sperm capacitation (GO:0048240)2.92321930
59positive regulation of protein dephosphorylation (GO:0035307)2.89644334
60branching involved in prostate gland morphogenesis (GO:0060442)2.88379596
61macrophage activation involved in immune response (GO:0002281)2.88144066
62NADPH regeneration (GO:0006740)2.87307785
63membrane hyperpolarization (GO:0060081)2.86837495
64macroautophagy (GO:0016236)2.86506345
65regulation of regulated secretory pathway (GO:1903305)2.84838271
66neuronal ion channel clustering (GO:0045161)2.84696076
67intracellular estrogen receptor signaling pathway (GO:0030520)2.83932599
68G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.83251065
69regulation of synaptic plasticity (GO:0048167)2.82780520
70protein localization to endosome (GO:0036010)2.82493347
71activation of protein kinase A activity (GO:0034199)2.82390867
72antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.81948849
73neuromuscular process controlling balance (GO:0050885)2.81412313
74positive regulation of sodium ion transmembrane transport (GO:1902307)2.81113648
75neutral amino acid transport (GO:0015804)2.80489864
76synaptic vesicle exocytosis (GO:0016079)2.79614686
77cellular sodium ion homeostasis (GO:0006883)2.79392254
78regulation of triglyceride catabolic process (GO:0010896)2.78524609
79membrane tubulation (GO:0097320)2.78185272
80vitamin A metabolic process (GO:0006776)2.77969616
81positive regulation of Cdc42 GTPase activity (GO:0043089)2.76987839
82ensheathment of neurons (GO:0007272)2.76948295
83axon ensheathment (GO:0008366)2.76948295
84membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.75814742
85antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.71098726
86response to hepatocyte growth factor (GO:0035728)2.70985516
87cellular response to hepatocyte growth factor stimulus (GO:0035729)2.70985516
88synaptic vesicle endocytosis (GO:0048488)2.69427015
89negative regulation of tumor necrosis factor-mediated signaling pathway (GO:0010804)2.69321213
90regulation of early endosome to late endosome transport (GO:2000641)2.68190617
91regulation of translational fidelity (GO:0006450)2.68116380
92neurotransmitter transport (GO:0006836)2.67609786
93layer formation in cerebral cortex (GO:0021819)2.67595012
94cell communication by electrical coupling (GO:0010644)2.67418298
95regulation of long-term neuronal synaptic plasticity (GO:0048169)2.64429843
96positive regulation of cellular amide metabolic process (GO:0034250)2.62798715
97regulation of cholesterol homeostasis (GO:2000188)2.62227001
98regulation of Rap GTPase activity (GO:0032317)2.62185220
99mating behavior (GO:0007617)2.61383771
100apical protein localization (GO:0045176)2.60495521
101sulfur compound transport (GO:0072348)2.60145392
102regulation of T-helper 2 cell differentiation (GO:0045628)2.59905900
103neuromuscular process controlling posture (GO:0050884)2.59789936
104diacylglycerol metabolic process (GO:0046339)2.59364130
105antigen processing and presentation of endogenous antigen (GO:0019883)2.58660390
106hormone catabolic process (GO:0042447)2.58499261
107myelination (GO:0042552)2.57627500
108regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.56857531
109glycolytic process (GO:0006096)2.56349246
110actin filament polymerization (GO:0030041)2.54972387
111regulation of amyloid precursor protein catabolic process (GO:1902991)2.54921455
112regulation of cellular amide metabolic process (GO:0034248)2.54155101
113regulation of synapse maturation (GO:0090128)2.53873201
114adenosine receptor signaling pathway (GO:0001973)2.53434193
115regulation of ARF protein signal transduction (GO:0032012)2.52955026
116dopamine receptor signaling pathway (GO:0007212)2.51623731
117potassium ion import (GO:0010107)2.50615008
118cell junction maintenance (GO:0034331)2.50352784
119detection of light stimulus involved in sensory perception (GO:0050962)2.49847755
120detection of light stimulus involved in visual perception (GO:0050908)2.49847755
121adhesion of symbiont to host (GO:0044406)2.49807162
122regulation of beta-amyloid formation (GO:1902003)2.49499214
123regulation of leukocyte degranulation (GO:0043300)2.48829226
124negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.48635418
125positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.48276521
126exploration behavior (GO:0035640)2.46250696
127mannose metabolic process (GO:0006013)2.46092799
128determination of adult lifespan (GO:0008340)2.46050125
129glutathione biosynthetic process (GO:0006750)2.45913428
130regulation of synaptic vesicle exocytosis (GO:2000300)2.45877413
131adult walking behavior (GO:0007628)2.45462243
132regulation of protein dephosphorylation (GO:0035304)2.44501039
133establishment or maintenance of apical/basal cell polarity (GO:0035088)2.44331311
134establishment or maintenance of bipolar cell polarity (GO:0061245)2.44331311
135detection of other organism (GO:0098543)2.43706711
136antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.43658732
137positive regulation of regulated secretory pathway (GO:1903307)2.43506949
138peptidyl-cysteine modification (GO:0018198)2.42921031
139sulfate transmembrane transport (GO:1902358)2.42804607
140regulation of myeloid leukocyte mediated immunity (GO:0002886)2.42222269
141negative regulation of peptidyl-threonine phosphorylation (GO:0010801)2.41898385
142response to peptidoglycan (GO:0032494)2.40955526
143negative regulation of toll-like receptor signaling pathway (GO:0034122)2.40795985
144Golgi to endosome transport (GO:0006895)2.40655481
145regulation of glutamate receptor signaling pathway (GO:1900449)2.40475903
146positive regulation of neurotransmitter secretion (GO:0001956)2.40271011
147asymmetric protein localization (GO:0008105)2.38977707
148vocalization behavior (GO:0071625)2.38574807
149NADH metabolic process (GO:0006734)2.37907456
150protein complex localization (GO:0031503)2.37830314
151organelle transport along microtubule (GO:0072384)2.37191122
152cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.35329130
153regulation of ARF GTPase activity (GO:0032312)2.35222950
154negative regulation of circadian rhythm (GO:0042754)2.34875282
155beta-amyloid metabolic process (GO:0050435)2.34788008
156regulation of neurotransmitter levels (GO:0001505)2.34534309
157detection of bacterium (GO:0016045)2.34031590
158regulation of bile acid biosynthetic process (GO:0070857)2.34028389
159cellular response to electrical stimulus (GO:0071257)2.33923351
160activation of Rac GTPase activity (GO:0032863)2.33785026
161L-serine transport (GO:0015825)2.33632434
162histone H4-K12 acetylation (GO:0043983)2.32354636
163regulation of viral release from host cell (GO:1902186)2.31955046
164negative regulation of protein oligomerization (GO:0032460)2.31169389
165triglyceride biosynthetic process (GO:0019432)2.30981856
166ionotropic glutamate receptor signaling pathway (GO:0035235)2.30802350
167long-term synaptic potentiation (GO:0060291)2.29223466
168glutamate secretion (GO:0014047)2.29192513
169regulation of synapse structural plasticity (GO:0051823)2.29093591
170positive regulation of establishment of protein localization to plasma membrane (GO:0090004)2.28771899
171positive regulation of neurotransmitter transport (GO:0051590)2.28137613
172cellular response to catecholamine stimulus (GO:0071870)2.26185022
173cellular response to monoamine stimulus (GO:0071868)2.26185022
174negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.25608148
175positive regulation of membrane potential (GO:0045838)2.25473614
176positive regulation of dendritic spine development (GO:0060999)2.25089314
177barbed-end actin filament capping (GO:0051016)2.21358182

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse3.52110301
2SMAD3_22036565_ChIP-Seq_ESCs_Mouse3.45850619
3POU5F1_18700969_ChIP-ChIP_MESCs_Mouse3.41143698
4KLF2_18264089_ChIP-ChIP_MESCs_Mouse3.32631241
5KLF5_18264089_ChIP-ChIP_MESCs_Mouse3.32631241
6KLF4_18264089_ChIP-ChIP_MESCs_Mouse3.32631241
7EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse3.06078647
8NANOG_18700969_ChIP-ChIP_MESCs_Mouse3.01008627
9SMAD1_18555785_ChIP-Seq_MESCs_Mouse2.96161304
10ZNF263_19887448_ChIP-Seq_K562_Human2.86114419
11* NACC1_18358816_ChIP-ChIP_MESCs_Mouse2.46017191
12ZIC3_20872845_ChIP-ChIP_MESCs_Mouse2.31037151
13* NR0B1_18358816_ChIP-ChIP_MESCs_Mouse2.28652972
14GATA1_26923725_Chip-Seq_HPCs_Mouse2.14519304
15TCF3_18692474_ChIP-Seq_MEFs_Mouse2.03666113
16NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.01909427
17* TCF3_18692474_ChIP-Seq_MESCs_Mouse2.00609256
18* SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.98993474
19* SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.98146938
20STAT3_1855785_ChIP-Seq_MESCs_Mouse1.96963958
21RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.81015488
22* KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.80061160
23ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.79831685
24STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.79719602
25ELK3_25401928_ChIP-Seq_HUVEC_Human1.78941170
26SOX2_27498859_Chip-Seq_STOMACH_Mouse1.77388304
27* NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.75749795
28RARG_19884340_ChIP-ChIP_MEFs_Mouse1.69919020
29ESR2_21235772_ChIP-Seq_MCF-7_Human1.69391956
30* ZFP281_18757296_ChIP-ChIP_E14_Mouse1.68634487
31SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.68350974
32NANOG_18555785_ChIP-Seq_MESCs_Mouse1.67925481
33IKZF1_21737484_ChIP-ChIP_HCT116_Human1.66328503
34KDM2B_26808549_Chip-Seq_DND41_Human1.65743501
35* TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.64942256
36MYC_22102868_ChIP-Seq_BL_Human1.60725072
37* KAP1_27257070_Chip-Seq_ESCs_Mouse1.59747390
38VDR_24763502_ChIP-Seq_THP-1_Human1.59043680
39* NANOG_18692474_ChIP-Seq_MESCs_Mouse1.58724069
40* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.58577603
41* RACK7_27058665_Chip-Seq_MCF-7_Human1.56033175
42* ZFP281_27345836_Chip-Seq_ESCs_Mouse1.55637503
43TP63_17297297_ChIP-ChIP_HaCaT_Human1.55520579
44CDX2_20551321_ChIP-Seq_CACO-2_Human1.55358774
45SRY_22984422_ChIP-ChIP_TESTIS_Rat1.53430822
46KDM2B_26808549_Chip-Seq_K562_Human1.53043590
47LXR_22292898_ChIP-Seq_THP-1_Human1.52901763
48P68_20966046_ChIP-Seq_HELA_Human1.50816143
49POU5F1_16518401_ChIP-PET_MESCs_Mouse1.48663928
50RARB_27405468_Chip-Seq_BRAIN_Mouse1.48297453
51* VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.47568582
52* SA1_27219007_Chip-Seq_ERYTHROID_Human1.44991399
53CTCF_27219007_Chip-Seq_ERYTHROID_Human1.44789853
54NANOG_18692474_ChIP-Seq_MEFs_Mouse1.44605980
55PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.43406371
56CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.41830201
57SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.40087727
58* TCF3_18347094_ChIP-ChIP_MESCs_Mouse1.39085807
59* RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.39018670
60ESR1_21235772_ChIP-Seq_MCF-7_Human1.36637189
61* SOX2_18692474_ChIP-Seq_MESCs_Mouse1.36323679
62* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.36300673
63DROSHA_22980978_ChIP-Seq_HELA_Human1.36024599
64* UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.35781814
65GATA1_19941827_ChIP-Seq_MEL_Mouse1.35304395
66WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.32258867
67GATA6_25053715_ChIP-Seq_YYC3_Human1.32075935
68TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.31382945
69* KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.31309714
70CREB1_26743006_Chip-Seq_LNCaP_Human1.31002925
71* GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.30561160
72MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.30524184
73STAT6_21828071_ChIP-Seq_BEAS2B_Human1.29325708
74SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.29253581
75* NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.29068564
76TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.28992310
77MTF2_20144788_ChIP-Seq_MESCs_Mouse1.28444999
78ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.25470350
79BP1_19119308_ChIP-ChIP_Hs578T_Human1.25043441
80* RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.24037176
81FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.24016260
82BCOR_27268052_Chip-Seq_Bcells_Human1.23502248
83* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.23041561
84CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.22763244
85RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.22184021
86* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.21791695
87* POU5F1_18692474_ChIP-Seq_MESCs_Mouse1.21521520
88SPI1_23127762_ChIP-Seq_K562_Human1.21474907
89SUZ12_27294783_Chip-Seq_ESCs_Mouse1.21236605
90RUNX1_27514584_Chip-Seq_MCF-7_Human1.20825917
91ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.20717935
92SMC4_20622854_ChIP-Seq_HELA_Human1.19240651
93SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.18750823
94OCT4_18692474_ChIP-Seq_MEFs_Mouse1.18252998
95VDR_21846776_ChIP-Seq_THP-1_Human1.17372668
96KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.17262699
97* RUNX1_22412390_ChIP-Seq_EML_Mouse1.16467534
98PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.13670762
99ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.13595443
100E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.13057418
101ERG_21242973_ChIP-ChIP_JURKAT_Human1.13044486
102SOX2_18692474_ChIP-Seq_MEFs_Mouse1.12949415
103TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.11165165
104ATF3_27146783_Chip-Seq_COLON_Human1.11151312
105MAF_26560356_Chip-Seq_TH1_Human1.10788186
106SA1_27219007_Chip-Seq_Bcells_Human1.10775604
107PHF8_20622854_ChIP-Seq_HELA_Human1.10407588
108PRDM14_21183938_ChIP-Seq_MESCs_Mouse1.09664460
109EZH2_27294783_Chip-Seq_ESCs_Mouse1.09342658
110* P300_27058665_Chip-Seq_ZR-75-30cells_Human1.07260929
111PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.07220238
112TCF7_22412390_ChIP-Seq_EML_Mouse1.07177809
113* BRD4_27068464_Chip-Seq_AML-cells_Mouse1.07114065
114* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.05707234
115PPARA_22158963_ChIP-Seq_LIVER_Mouse1.05664282
116KDM2B_26808549_Chip-Seq_JURKAT_Human1.05455848
117FOXO3_23340844_ChIP-Seq_DLD1_Human1.05368063
118JARID2_20075857_ChIP-Seq_MESCs_Mouse1.05367430
119SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.04877915
120* DNAJC2_21179169_ChIP-ChIP_NT2_Human1.04839907
121PU.1_20513432_ChIP-Seq_Bcells_Mouse1.04627438
122KLF4_18555785_ChIP-Seq_MESCs_Mouse1.04250983
123SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.04023840
124KLF5_25053715_ChIP-Seq_YYC3_Human1.03454697
125REST_21632747_ChIP-Seq_MESCs_Mouse1.03165183
126* MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.02670764
127RXR_22158963_ChIP-Seq_LIVER_Mouse1.01884097
128BCL6_27268052_Chip-Seq_Bcells_Human1.01768915
129RNF2_27304074_Chip-Seq_ESCs_Mouse1.01442028
130MAF_26560356_Chip-Seq_TH2_Human1.01073929
131OCT4_19829295_ChIP-Seq_ESCs_Human1.00192988
132REST_18959480_ChIP-ChIP_MESCs_Mouse0.99864515
133YY1_22570637_ChIP-Seq_MALME-3M_Human0.99645682
134* GATA1_22383799_ChIP-Seq_G1ME_Mouse0.98928848
135SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.98645481
136ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.98450504
137NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.98231348
138SCL_19346495_ChIP-Seq_HPC-7_Human0.97922554
139TET1_21490601_ChIP-Seq_MESCs_Mouse0.97834662
140MYB_21317192_ChIP-Seq_ERMYB_Mouse0.97548789
141* CTCF_27219007_Chip-Seq_Bcells_Human0.96876033
142GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.96693145
143TET1_21451524_ChIP-Seq_MESCs_Mouse0.96553375
144SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.96401593
145NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.94958912
146* TP63_22573176_ChIP-Seq_HFKS_Human0.94174480
147STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.94034590
148* POU5F1_18347094_ChIP-ChIP_MESCs_Mouse0.93460064

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010234_abnormal_vibrissa_follicle3.97844008
2MP0005360_urolithiasis3.08271948
3MP0004885_abnormal_endolymph3.04405270
4MP0003329_amyloid_beta_deposits2.83648911
5MP0004859_abnormal_synaptic_plasticity2.83118225
6MP0009840_abnormal_foam_cell2.76595798
7MP0002653_abnormal_ependyma_morphology2.72094367
8MP0004264_abnormal_extraembryonic_tissu2.64463627
9MP0003303_peritoneal_inflammation2.61342856
10MP0004270_analgesia2.50298379
11MP0000462_abnormal_digestive_system2.41810889
12MP0004185_abnormal_adipocyte_glucose2.31148331
13MP0005310_abnormal_salivary_gland2.22899028
14MP0003183_abnormal_peptide_metabolism2.20385589
15MP0008260_abnormal_autophagy2.14796276
16MP0003866_abnormal_defecation2.10457463
17MP0003436_decreased_susceptibility_to2.08678086
18MP0004043_abnormal_pH_regulation2.02093262
19MP0001666_abnormal_nutrient_absorption1.96376021
20MP0001849_ear_inflammation1.91760708
21MP0001873_stomach_inflammation1.86244504
22MP0003806_abnormal_nucleotide_metabolis1.85826518
23MP0000920_abnormal_myelination1.82946919
24MP0005666_abnormal_adipose_tissue1.82695345
25MP0003724_increased_susceptibility_to1.78826772
26MP0002822_catalepsy1.78311973
27MP0003950_abnormal_plasma_membrane1.77167095
28MP0004510_myositis1.76126411
29MP0005551_abnormal_eye_electrophysiolog1.75551628
30MP0005409_darkened_coat_color1.71104759
31MP0000604_amyloidosis1.70011137
32MP0000537_abnormal_urethra_morphology1.69340729
33MP0002229_neurodegeneration1.67865346
34MP0004858_abnormal_nervous_system1.67317352
35MP0008872_abnormal_physiological_respon1.64018055
36MP0005670_abnormal_white_adipose1.62157115
37MP0002272_abnormal_nervous_system1.60718730
38MP0003635_abnormal_synaptic_transmissio1.57419173
39MP0003123_paternal_imprinting1.54801466
40MP0005451_abnormal_body_composition1.51605065
41MP0005381_digestive/alimentary_phenotyp1.43327599
42MP0000477_abnormal_intestine_morphology1.40111832
43MP0002734_abnormal_mechanical_nocicepti1.39862271
44MP0010352_gastrointestinal_tract_polyps1.37829970
45MP0004130_abnormal_muscle_cell1.36961348
46MP0003632_abnormal_nervous_system1.36390590
47MP0001486_abnormal_startle_reflex1.36287312
48MP0002419_abnormal_innate_immunity1.35090492
49MP0000490_abnormal_crypts_of1.34100391
50MP0001663_abnormal_digestive_system1.31446464
51MP0010329_abnormal_lipoprotein_level1.30222621
52MP0001502_abnormal_circadian_rhythm1.30135169
53MP0003705_abnormal_hypodermis_morpholog1.29265671
54MP0005423_abnormal_somatic_nervous1.27723447
55MP0004947_skin_inflammation1.27481462
56MP0000955_abnormal_spinal_cord1.26353715
57MP0006082_CNS_inflammation1.25245341
58MP0004381_abnormal_hair_follicle1.25041128
59MP0006072_abnormal_retinal_apoptosis1.24850331
60MP0005025_abnormal_response_to1.24777579
61MP0003880_abnormal_central_pattern1.23085790
62MP0009278_abnormal_bone_marrow1.22792501
63MP0005535_abnormal_body_temperature1.20314080
64MP0005167_abnormal_blood-brain_barrier1.20170549
65MP0008569_lethality_at_weaning1.19996153
66MP0002064_seizures1.19033566
67MP0003300_gastrointestinal_ulcer1.16838934
68MP0002733_abnormal_thermal_nociception1.15089453
69MP0001968_abnormal_touch/_nociception1.13020407
70MP0001970_abnormal_pain_threshold1.10930580
71MP0001533_abnormal_skeleton_physiology1.10299186
72MP0009780_abnormal_chondrocyte_physiolo1.08116023
73MP0005410_abnormal_fertilization1.07827042
74MP0001664_abnormal_digestion1.07794153
75MP0003879_abnormal_hair_cell1.07651649
76MP0005076_abnormal_cell_differentiation1.05919877
77MP0004133_heterotaxia1.05642382
78MP0003634_abnormal_glial_cell1.05512948
79MP0005000_abnormal_immune_tolerance1.05349552
80MP0002063_abnormal_learning/memory/cond1.04411826
81MP0003453_abnormal_keratinocyte_physiol1.03072709
82MP0010155_abnormal_intestine_physiology1.02106901
83MP0001730_embryonic_growth_arrest1.01790804
84MP0003690_abnormal_glial_cell1.01133785
85MP0001440_abnormal_grooming_behavior1.00225393
86MP0003075_altered_response_to1.00126018
87MP0005375_adipose_tissue_phenotype1.00081117
88MP0001765_abnormal_ion_homeostasis0.99074171
89MP0004233_abnormal_muscle_weight0.97513255
90MP0010678_abnormal_skin_adnexa0.96584537
91MP0002882_abnormal_neuron_morphology0.94652035
92MP0000778_abnormal_nervous_system0.93425456
93MP0002998_abnormal_bone_remodeling0.92789700
94MP0003718_maternal_effect0.92084305
95MP0003698_abnormal_male_reproductive0.91704487
96MP0004742_abnormal_vestibular_system0.90925088
97MP0005266_abnormal_metabolism0.90884669
98MP0001485_abnormal_pinna_reflex0.90871886
99MP0002971_abnormal_brown_adipose0.90670138
100MP0002796_impaired_skin_barrier0.90496168
101MP0003631_nervous_system_phenotype0.89828388
102MP0000467_abnormal_esophagus_morphology0.89271496
103MP0009745_abnormal_behavioral_response0.89228812
104MP0002089_abnormal_postnatal_growth/wei0.86686914
105MP0004957_abnormal_blastocyst_morpholog0.86529316
106MP0002066_abnormal_motor_capabilities/c0.85100831
107MP0002184_abnormal_innervation0.84884833
108MP0003191_abnormal_cellular_cholesterol0.84734928
109MP0001790_abnormal_immune_system0.84452170
110MP0005387_immune_system_phenotype0.84452170
111MP0002909_abnormal_adrenal_gland0.83708084
112MP0002572_abnormal_emotion/affect_behav0.82223297
113MP0004142_abnormal_muscle_tone0.81562040
114MP0003045_fibrosis0.81387170
115MP0001501_abnormal_sleep_pattern0.81198133
116MP0003172_abnormal_lysosome_physiology0.81137810
117MP0002420_abnormal_adaptive_immunity0.80496498
118MP0001819_abnormal_immune_cell0.80139126
119MP0002090_abnormal_vision0.79951453
120MP0003111_abnormal_nucleus_morphology0.79688787
121MP0002118_abnormal_lipid_homeostasis0.79447422
122MP0001851_eye_inflammation0.78966913
123MP0005647_abnormal_sex_gland0.78407076
124MP0000678_abnormal_parathyroid_gland0.78392232
125MP0003633_abnormal_nervous_system0.76845594
126MP0005253_abnormal_eye_physiology0.76386956
127MP0004811_abnormal_neuron_physiology0.75810949
128* MP0002152_abnormal_brain_morphology0.75495000
129MP0002723_abnormal_immune_serum0.74930583
130MP0002148_abnormal_hypersensitivity_rea0.73604605
131MP0008873_increased_physiological_sensi0.73359658
132MP0005195_abnormal_posterior_eye0.73332008
133MP0000858_altered_metastatic_potential0.72811336
134MP0008874_decreased_physiological_sensi0.71524348
135MP0005501_abnormal_skin_physiology0.71177644
136MP0005166_decreased_susceptibility_to0.70996608
137MP0005058_abnormal_lysosome_morphology0.70861496
138MP0009046_muscle_twitch0.70719550
139MP0001835_abnormal_antigen_presentation0.70417820
140MP0001929_abnormal_gametogenesis0.69319986
141MP0005464_abnormal_platelet_physiology0.66662025
142MP0004019_abnormal_vitamin_homeostasis0.65812299
143MP0001348_abnormal_lacrimal_gland0.64232188
144MP0002452_abnormal_antigen_presenting0.63496209

Predicted human phenotypes

RankGene SetZ-score
1Ependymoma (HP:0002888)4.61810600
2Cerebral hypomyelination (HP:0006808)4.12735680
3Congenital stationary night blindness (HP:0007642)3.78662650
4Obstructive sleep apnea (HP:0002870)3.71717087
5Neurofibrillary tangles (HP:0002185)3.64643562
6Abnormality of the astrocytes (HP:0100707)3.62171120
7Astrocytoma (HP:0009592)3.62171120
8Abnormality of the corticospinal tract (HP:0002492)3.59770974
9Eczematoid dermatitis (HP:0000976)3.57870755
10Abnormality of proline metabolism (HP:0010907)3.55462039
11Hydroxyprolinuria (HP:0003080)3.55462039
12CNS hypomyelination (HP:0003429)3.47826578
13Degeneration of the lateral corticospinal tracts (HP:0002314)3.37791254
14Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)3.37791254
15Abnormality of binocular vision (HP:0011514)3.32737882
16Diplopia (HP:0000651)3.32737882
17Neoplasm of the oral cavity (HP:0100649)3.32486277
18Peripheral hypomyelination (HP:0007182)3.32245031
19Abnormality of cochlea (HP:0000375)3.31157144
20Intention tremor (HP:0002080)3.30355190
21Abnormality of the salivary glands (HP:0010286)3.23445249
22Abnormality of the lower motor neuron (HP:0002366)3.22515764
23Esophageal atresia (HP:0002032)3.22136670
24Supranuclear gaze palsy (HP:0000605)3.19579974
25Cerebral inclusion bodies (HP:0100314)3.18765481
26Ileus (HP:0002595)3.11446832
27Myokymia (HP:0002411)3.07148429
28Morphological abnormality of the inner ear (HP:0011390)3.06793357
29Ankle clonus (HP:0011448)3.02322648
30Termporal pattern (HP:0011008)2.92851342
31Insidious onset (HP:0003587)2.92851342
32Male infertility (HP:0003251)2.92400849
33Abnormality of glutamine family amino acid metabolism (HP:0010902)2.89398465
34Increased cerebral lipofuscin (HP:0011813)2.87552610
35Abnormality of macrophages (HP:0004311)2.83582933
36Spastic gait (HP:0002064)2.81529608
37Annular pancreas (HP:0001734)2.74004725
38Axonal loss (HP:0003447)2.68295650
39Recurrent abscess formation (HP:0002722)2.65652093
40Focal motor seizures (HP:0011153)2.63941877
41Hand muscle atrophy (HP:0009130)2.61824583
42Amyloidosis (HP:0011034)2.61663460
43Spastic tetraparesis (HP:0001285)2.56735522
44Slow saccadic eye movements (HP:0000514)2.55567812
45Abnormal eating behavior (HP:0100738)2.54889147
46Diminished motivation (HP:0000745)2.54589691
47Recurrent bacterial skin infections (HP:0005406)2.54547730
48Increased neuronal autofluorescent lipopigment (HP:0002074)2.51093332
49Dysmetria (HP:0001310)2.50103808
50Pili torti (HP:0003777)2.46538915
51Morphological abnormality of the pyramidal tract (HP:0002062)2.43828678
52Action tremor (HP:0002345)2.40677517
53Amyotrophic lateral sclerosis (HP:0007354)2.40389471
54Hyperparathyroidism (HP:0000843)2.39755088
55Hyperglycinuria (HP:0003108)2.38591186
56Urinary urgency (HP:0000012)2.37569929
57Onion bulb formation (HP:0003383)2.35533066
58Truncal ataxia (HP:0002078)2.34280296
59Mutism (HP:0002300)2.34168500
60Cellulitis (HP:0100658)2.34156018
61Rapidly progressive (HP:0003678)2.34130325
62Biliary tract neoplasm (HP:0100574)2.33811943
63Distal upper limb amyotrophy (HP:0007149)2.30205718
64Upper limb amyotrophy (HP:0009129)2.30205718
65Polygenic inheritance (HP:0010982)2.29492358
66Urinary bladder sphincter dysfunction (HP:0002839)2.29372403
67Dementia (HP:0000726)2.29009844
68Loss of speech (HP:0002371)2.28544044
69Recurrent gram-negative bacterial infections (HP:0005420)2.28479218
70Clumsiness (HP:0002312)2.28211508
71Tetraplegia (HP:0002445)2.28143015
72Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.27093320
73Depression (HP:0000716)2.26619995
74Agnosia (HP:0010524)2.26444060
75Glioma (HP:0009733)2.26007068
76Rigidity (HP:0002063)2.25088674
77Dysostosis multiplex (HP:0000943)2.23804542
78Abnormality of glycolipid metabolism (HP:0010969)2.23681547
79Abnormality of liposaccharide metabolism (HP:0010968)2.23681547
80Abnormality of glycosphingolipid metabolism (HP:0004343)2.23681547
81Spastic paraplegia (HP:0001258)2.23518465
82Central scotoma (HP:0000603)2.22898257
83Orchitis (HP:0100796)2.21093414
84Hemiplegia (HP:0002301)2.20034391
85Malnutrition (HP:0004395)2.19351693
86Myositis (HP:0100614)2.19145018
87Focal seizures (HP:0007359)2.18687972
88Medulloblastoma (HP:0002885)2.15698233
89Ventricular fibrillation (HP:0001663)2.15400577
90Ocular albinism (HP:0001107)2.15175735
91Systemic lupus erythematosus (HP:0002725)2.14956742
92Papilledema (HP:0001085)2.14798927
93Gingivitis (HP:0000230)2.13930540
94Segmental peripheral demyelination/remyelination (HP:0003481)2.13515785
95Akinesia (HP:0002304)2.05726118
96Visual hallucinations (HP:0002367)2.05670768
97Distal lower limb muscle weakness (HP:0009053)2.05539329
98Abnormality of the labia minora (HP:0012880)2.01591582
99Growth hormone excess (HP:0000845)2.01466292
100Hypercortisolism (HP:0001578)2.01178572
101Abnormality of serine family amino acid metabolism (HP:0010894)2.00793446
102Abnormality of glycine metabolism (HP:0010895)2.00793446
103Scanning speech (HP:0002168)2.00177245
104Dysmetric saccades (HP:0000641)1.99446792
105Partial agenesis of the corpus callosum (HP:0001338)1.98561860
106Cerebral aneurysm (HP:0004944)1.98098132
107Foot dorsiflexor weakness (HP:0009027)1.97188464
108Subcapsular cataract (HP:0000523)1.96565789
109Epileptic encephalopathy (HP:0200134)1.96091340
110Postural instability (HP:0002172)1.95093097
111Heterotopia (HP:0002282)1.94454021
112Gastrointestinal dysmotility (HP:0002579)1.93641855
113Insomnia (HP:0100785)1.93251832
114Gastrointestinal atresia (HP:0002589)1.92561880
115Short humerus (HP:0005792)1.92433165
116Lower limb asymmetry (HP:0100559)1.92144828
117Clonus (HP:0002169)1.92064752
118Abnormality of macular pigmentation (HP:0008002)1.90750068
119Paraplegia (HP:0010550)1.90357317
120Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.89160910
121Choreoathetosis (HP:0001266)1.87191850
122Abnormality of polysaccharide metabolism (HP:0011012)1.86267658
123Abnormality of glycosaminoglycan metabolism (HP:0004371)1.86267658
124Abnormality of mucopolysaccharide metabolism (HP:0011020)1.86267658
125Hyperacusis (HP:0010780)1.86099264
126Septo-optic dysplasia (HP:0100842)1.85819896
127Deep palmar crease (HP:0006191)1.84798198
128Overriding aorta (HP:0002623)1.84764205
129Urinary glycosaminoglycan excretion (HP:0003541)1.84509117
130Mucopolysacchariduria (HP:0008155)1.84509117
131Decreased motor nerve conduction velocity (HP:0003431)1.84082223
132Bundle branch block (HP:0011710)1.83847219
133Obstructive lung disease (HP:0006536)1.83782022
134Chronic obstructive pulmonary disease (HP:0006510)1.83782022
135Dysdiadochokinesis (HP:0002075)1.83751874
136Albinism (HP:0001022)1.83355462
137Hyporeflexia of lower limbs (HP:0002600)1.82994994
138Torticollis (HP:0000473)1.81530598
139Iris hypopigmentation (HP:0007730)1.79614070
140Abnormal auditory evoked potentials (HP:0006958)1.78090695
141J-shaped sella turcica (HP:0002680)1.77843310
142Polar cataract (HP:0010696)1.77429779
143Neuronal loss in central nervous system (HP:0002529)1.77152796
144Distal sensory impairment (HP:0002936)1.76369144
145Shawl scrotum (HP:0000049)1.75541281
146Lower limb amyotrophy (HP:0007210)1.75472358
147Choroideremia (HP:0001139)1.75124147
148Neoplasm of striated muscle (HP:0009728)1.74628813
149Hypertriglyceridemia (HP:0002155)1.74176926
150Bradykinesia (HP:0002067)1.73946291
151Abnormality of saccadic eye movements (HP:0000570)1.73721832
152Retrobulbar optic neuritis (HP:0100654)1.73630066
153Optic neuritis (HP:0100653)1.73630066
154Limb hypertonia (HP:0002509)1.73416326
155Hemorrhage of the eye (HP:0011885)1.72992886
156Abnormal rod and cone electroretinograms (HP:0008323)1.72374338
157Mediastinal lymphadenopathy (HP:0100721)1.72341213
158Urinary incontinence (HP:0000020)1.71881033
159Stereotypic behavior (HP:0000733)1.71873746
160Febrile seizures (HP:0002373)1.71777673
161Stridor (HP:0010307)1.71616007
162Abnormality of the periventricular white matter (HP:0002518)1.71357602
163Hammertoe (HP:0001765)1.70465349
164Impaired social interactions (HP:0000735)1.69848808
165Abnormal social behavior (HP:0012433)1.69848808
166Upper motor neuron abnormality (HP:0002127)1.69380444
167Apathy (HP:0000741)1.68797307
168Vertebral clefting (HP:0008428)1.67902648
169Abnormality of the diencephalon (HP:0010662)1.67732334
170Absent septum pellucidum (HP:0001331)1.67627946
171Widely patent fontanelles and sutures (HP:0004492)1.67610191
172Achilles tendon contracture (HP:0001771)1.67239572
173Aplasia/hypoplasia of the humerus (HP:0006507)1.66485278
174Neoplasm of the small intestine (HP:0100833)1.66159607

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K93.73334730
2EEF2K3.71046562
3RIPK43.47204259
4KSR23.31977789
5PRKD32.88079784
6TESK22.78824867
7ICK2.51476586
8AKT32.36536131
9PAK62.31067909
10DAPK22.26046185
11EPHA22.20976299
12SIK11.96045169
13LMTK21.85523437
14MAP3K111.82264528
15TNK21.80541649
16SMG11.77486393
17NEK11.73748228
18PRKG21.73736269
19STK391.67918369
20SCYL21.58523764
21TYRO31.56634223
22RIPK11.52300755
23MAP2K21.50574098
24MET1.50351615
25MAP3K131.47954051
26EPHB11.43548030
27MAPKAPK31.41583596
28ARAF1.40070760
29CDK121.38154966
30RPS6KB21.37572572
31NTRK11.36136229
32MAP3K21.35946378
33MAP3K11.35660117
34CDK191.31619756
35TTK1.31202251
36TAOK11.28989126
37MAP4K11.28287671
38MAP2K31.27920284
39FES1.27375402
40GRK61.23464332
41MST41.20012990
42BMX1.19461854
43IRAK41.16841725
44MAP3K31.16550649
45IRAK21.14463616
46OXSR11.13652060
47TAOK21.10552226
48BCKDK1.10017268
49RAF11.05493201
50ALK1.05156013
51MAPK121.04755799
52PTK61.04495426
53STK101.01226650
54MAPKAPK51.01069197
55LIMK10.99774438
56IRAK30.99647508
57TRIB30.97765527
58PDPK10.95184947
59LATS20.95038632
60PDK10.94148906
61PRKD20.93050402
62MAP3K80.92948808
63MAP3K40.91367518
64PKN10.91128855
65MAP3K100.90974886
66CAMK10.89678543
67SIK20.89527383
68PKN20.88503196
69STK380.88141764
70TYK20.87925492
71BRAF0.87175930
72NTRK20.86885231
73CSK0.86805141
74FGFR40.86015764
75PRKCH0.86010052
76SGK30.84498982
77NEK60.81968376
78MAP3K60.81743216
79ERBB40.81609213
80TESK10.81351798
81MATK0.80679412
82ROCK20.80270240
83MARK10.79019399
84FGR0.78069417
85RET0.77429230
86MARK20.77247825
87DAPK10.76941715
88BLK0.75383436
89PRKCI0.75248074
90FLT30.74729268
91RPS6KA20.74045319
92JAK20.73468236
93GRK50.73177766
94PAK10.72205072
95CDC42BPA0.72132744
96CDK150.71792363
97PDK20.71330156
98STK110.71240119
99ZAP700.68600129
100TBK10.67801226
101CDK11A0.67755102
102LATS10.66207904
103SGK2230.65400949
104SGK4940.65400949
105DYRK20.64607208
106TAOK30.63831443
107MINK10.63495740
108CDK140.62008340
109UHMK10.60910760
110JAK10.60078090
111CDK180.59154472
112KSR10.58879241
113CDK50.57734729
114FYN0.56653540
115PAK40.52816416
116PRKCZ0.52472391
117MELK0.51710370
118SIK30.51289114
119HCK0.50778691
120MAP2K60.50258205
121PNCK0.49871534
122HIPK20.49091600
123MTOR0.48923096
124CAMK40.48537563
125ERN10.48514723
126CSNK1G30.48241692
127PRKAA10.47881778
128CAMK1D0.47807436
129CSNK1G20.47735097
130AKT20.47721930
131PHKG10.47344347
132PHKG20.47344347
133SGK20.46486634
134CAMK2G0.44681975
135MAP2K40.44602820
136LRRK20.44124995
137MAPK40.44049242
138DMPK0.43322181
139CDK70.41705285
140NEK20.39981412
141EPHA40.39827244
142PRPF4B0.38789146
143CAMKK10.38635760
144CSNK1E0.38599647
145NTRK30.38182925
146CAMK2B0.37820338
147FRK0.36874894
148FER0.35710207
149DAPK30.35502818
150CSNK1D0.35476101

Predicted pathways (KEGG)

RankGene SetZ-score
1Nitrogen metabolism_Homo sapiens_hsa009104.35909101
2Fat digestion and absorption_Homo sapiens_hsa049752.56197922
3Mineral absorption_Homo sapiens_hsa049782.31506784
4Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006012.22076517
5Fructose and mannose metabolism_Homo sapiens_hsa000512.14786106
62-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.13945287
7Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049642.13899954
8Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.91017806
9Synaptic vesicle cycle_Homo sapiens_hsa047211.87002267
10Carbohydrate digestion and absorption_Homo sapiens_hsa049731.85993573
11Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.74944421
12Biosynthesis of amino acids_Homo sapiens_hsa012301.66053567
13Renin-angiotensin system_Homo sapiens_hsa046141.63942833
14Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.60592251
15Arginine biosynthesis_Homo sapiens_hsa002201.59542542
16Bile secretion_Homo sapiens_hsa049761.56584761
17Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.51054874
18Glycerolipid metabolism_Homo sapiens_hsa005611.43557701
19Glycerophospholipid metabolism_Homo sapiens_hsa005641.43423202
20Osteoclast differentiation_Homo sapiens_hsa043801.41951127
21Amphetamine addiction_Homo sapiens_hsa050311.41735507
22Cyanoamino acid metabolism_Homo sapiens_hsa004601.41687757
23Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050141.41012965
24Folate biosynthesis_Homo sapiens_hsa007901.35502446
25Central carbon metabolism in cancer_Homo sapiens_hsa052301.33045418
26Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.31547910
27Fatty acid biosynthesis_Homo sapiens_hsa000611.30472646
28B cell receptor signaling pathway_Homo sapiens_hsa046621.24167305
29Choline metabolism in cancer_Homo sapiens_hsa052311.22492675
30Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.19544249
31Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.19073496
32Salivary secretion_Homo sapiens_hsa049701.18824926
33Prion diseases_Homo sapiens_hsa050201.17384911
34Neurotrophin signaling pathway_Homo sapiens_hsa047221.16851599
35Tight junction_Homo sapiens_hsa045301.16321110
36Other glycan degradation_Homo sapiens_hsa005111.13114833
37Galactose metabolism_Homo sapiens_hsa000521.12711245
38Arginine and proline metabolism_Homo sapiens_hsa003301.12282938
39Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.12131115
40Gap junction_Homo sapiens_hsa045401.09554847
41Sulfur metabolism_Homo sapiens_hsa009201.09283020
42VEGF signaling pathway_Homo sapiens_hsa043701.07745528
43alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.07380885
44* Phosphatidylinositol signaling system_Homo sapiens_hsa040701.07105565
45mTOR signaling pathway_Homo sapiens_hsa041501.05556504
46Leishmaniasis_Homo sapiens_hsa051401.05354055
47Vitamin digestion and absorption_Homo sapiens_hsa049771.03842845
48Cocaine addiction_Homo sapiens_hsa050301.03616861
49Tuberculosis_Homo sapiens_hsa051521.02659158
50Histidine metabolism_Homo sapiens_hsa003401.02155780
51Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.01285660
52Carbon metabolism_Homo sapiens_hsa012000.98859702
53Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.96985191
54Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.96327959
55Vitamin B6 metabolism_Homo sapiens_hsa007500.96245334
56GABAergic synapse_Homo sapiens_hsa047270.95240976
57Pentose phosphate pathway_Homo sapiens_hsa000300.94886473
58Phospholipase D signaling pathway_Homo sapiens_hsa040720.94476894
59Chemokine signaling pathway_Homo sapiens_hsa040620.93757131
60Ether lipid metabolism_Homo sapiens_hsa005650.92948402
61Toll-like receptor signaling pathway_Homo sapiens_hsa046200.92491003
62Insulin signaling pathway_Homo sapiens_hsa049100.91735259
63GnRH signaling pathway_Homo sapiens_hsa049120.91728613
64Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.91298403
65Leukocyte transendothelial migration_Homo sapiens_hsa046700.89900665
66ErbB signaling pathway_Homo sapiens_hsa040120.89454303
67Long-term depression_Homo sapiens_hsa047300.88616818
68cAMP signaling pathway_Homo sapiens_hsa040240.88516764
69Gastric acid secretion_Homo sapiens_hsa049710.87303615
70PPAR signaling pathway_Homo sapiens_hsa033200.87221688
71Adipocytokine signaling pathway_Homo sapiens_hsa049200.86898390
72Endometrial cancer_Homo sapiens_hsa052130.86549759
73Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.86044578
74Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.85834671
75Renal cell carcinoma_Homo sapiens_hsa052110.85468241
76Pyruvate metabolism_Homo sapiens_hsa006200.84667058
77Estrogen signaling pathway_Homo sapiens_hsa049150.84648537
78* Inositol phosphate metabolism_Homo sapiens_hsa005620.83402284
79Vibrio cholerae infection_Homo sapiens_hsa051100.81837763
80AMPK signaling pathway_Homo sapiens_hsa041520.81633252
81Chronic myeloid leukemia_Homo sapiens_hsa052200.81567347
82Notch signaling pathway_Homo sapiens_hsa043300.79946946
83Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.79773532
84Lysosome_Homo sapiens_hsa041420.79594675
85Thyroid hormone synthesis_Homo sapiens_hsa049180.78786083
86Glutamatergic synapse_Homo sapiens_hsa047240.78682864
87Linoleic acid metabolism_Homo sapiens_hsa005910.76804323
88Sphingolipid signaling pathway_Homo sapiens_hsa040710.76439144
89Hepatitis C_Homo sapiens_hsa051600.76356096
90Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.76260536
91Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.75534321
92Colorectal cancer_Homo sapiens_hsa052100.73887410
93Staphylococcus aureus infection_Homo sapiens_hsa051500.73394120
94Rap1 signaling pathway_Homo sapiens_hsa040150.73002172
95Cholinergic synapse_Homo sapiens_hsa047250.71773661
96Type II diabetes mellitus_Homo sapiens_hsa049300.71451864
97Renin secretion_Homo sapiens_hsa049240.70205407
98Aldosterone synthesis and secretion_Homo sapiens_hsa049250.68363449
99Olfactory transduction_Homo sapiens_hsa047400.67902716
100Endocytosis_Homo sapiens_hsa041440.67652433
101Melanogenesis_Homo sapiens_hsa049160.67392671
102Acute myeloid leukemia_Homo sapiens_hsa052210.67208210
103Nicotine addiction_Homo sapiens_hsa050330.65963610
104Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.65263771
105Pancreatic secretion_Homo sapiens_hsa049720.65059531
106cGMP-PKG signaling pathway_Homo sapiens_hsa040220.63720717
107Collecting duct acid secretion_Homo sapiens_hsa049660.62865377
108Prolactin signaling pathway_Homo sapiens_hsa049170.62142045
109Glycosaminoglycan degradation_Homo sapiens_hsa005310.61804002
110Thyroid cancer_Homo sapiens_hsa052160.61440533
111Morphine addiction_Homo sapiens_hsa050320.61349381
112Non-small cell lung cancer_Homo sapiens_hsa052230.60611587
113MAPK signaling pathway_Homo sapiens_hsa040100.60536273
114Salmonella infection_Homo sapiens_hsa051320.59933390
115Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.59130578
116Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.58950345
117Long-term potentiation_Homo sapiens_hsa047200.57611609
118Calcium signaling pathway_Homo sapiens_hsa040200.55674721
119T cell receptor signaling pathway_Homo sapiens_hsa046600.55557863
120Toxoplasmosis_Homo sapiens_hsa051450.54611097
121Pancreatic cancer_Homo sapiens_hsa052120.54029063
122HIF-1 signaling pathway_Homo sapiens_hsa040660.52290795
123Circadian entrainment_Homo sapiens_hsa047130.52235233
124Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.51361457
125Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.51041101
126Dorso-ventral axis formation_Homo sapiens_hsa043200.50849965
127Phagosome_Homo sapiens_hsa041450.50821108
128Fatty acid degradation_Homo sapiens_hsa000710.50791398
129Insulin resistance_Homo sapiens_hsa049310.50534049
130Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.50506210
131Thyroid hormone signaling pathway_Homo sapiens_hsa049190.50117932
132Mismatch repair_Homo sapiens_hsa034300.49661040
133Cysteine and methionine metabolism_Homo sapiens_hsa002700.49228974
134Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.48565918
135Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.48135796
136Dopaminergic synapse_Homo sapiens_hsa047280.47545994
137Vascular smooth muscle contraction_Homo sapiens_hsa042700.46116253
138Glioma_Homo sapiens_hsa052140.45400329
139Propanoate metabolism_Homo sapiens_hsa006400.45298971
140Hippo signaling pathway_Homo sapiens_hsa043900.45211728
141Insulin secretion_Homo sapiens_hsa049110.44115464
142Oxytocin signaling pathway_Homo sapiens_hsa049210.44006954
143Longevity regulating pathway - mammal_Homo sapiens_hsa042110.43696796

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