ITPKA

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Regulates inositol phosphate metabolism by phosphorylation of second messenger inositol 1,4,5-trisphosphate to Ins(1,3,4,5)P4. The activity of the inositol 1,4,5-trisphosphate 3-kinase is responsible for regulating the levels of a large number of inositol polyphosphates that are important in cellular signaling. Both calcium/calmodulin and protein phosphorylation mechanisms control its activity. It is also a substrate for the cyclic AMP-dependent protein kinase, calcium/calmodulin- dependent protein kinase II, and protein kinase C in vitro. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of short-term neuronal synaptic plasticity (GO:0048172)6.13787953
2positive regulation of excitatory postsynaptic membrane potential (GO:2000463)6.09008283
3vocalization behavior (GO:0071625)5.75814016
4regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act5.74474491
5locomotory exploration behavior (GO:0035641)5.72089531
6synaptic vesicle maturation (GO:0016188)5.54406048
7ionotropic glutamate receptor signaling pathway (GO:0035235)5.52370534
8synaptic vesicle exocytosis (GO:0016079)5.47171079
9regulation of glutamate receptor signaling pathway (GO:1900449)5.41339017
10glutamate secretion (GO:0014047)5.29138743
11positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.28236283
12synaptic vesicle docking involved in exocytosis (GO:0016081)5.18795041
13regulation of long-term neuronal synaptic plasticity (GO:0048169)5.14798442
14protein localization to synapse (GO:0035418)5.06695428
15regulation of neuronal synaptic plasticity (GO:0048168)5.03976920
16glutamate receptor signaling pathway (GO:0007215)5.02030215
17regulation of synaptic vesicle exocytosis (GO:2000300)4.86280141
18neuronal action potential propagation (GO:0019227)4.82986859
19exploration behavior (GO:0035640)4.78472657
20synaptic transmission, glutamatergic (GO:0035249)4.71531498
21regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.57820956
22regulation of synaptic vesicle transport (GO:1902803)4.52443493
23L-amino acid import (GO:0043092)4.52328250
24neuron-neuron synaptic transmission (GO:0007270)4.47001085
25regulation of excitatory postsynaptic membrane potential (GO:0060079)4.45650704
26negative regulation of dendrite morphogenesis (GO:0050774)4.43083254
27cerebellar granule cell differentiation (GO:0021707)4.40420633
28long-term memory (GO:0007616)4.36335513
29neurotransmitter-gated ion channel clustering (GO:0072578)4.24337713
30dendritic spine morphogenesis (GO:0060997)4.23201798
31* regulation of synaptic plasticity (GO:0048167)4.22148600
32amino acid import (GO:0043090)4.21760873
33regulation of synapse structural plasticity (GO:0051823)4.20614827
34regulation of postsynaptic membrane potential (GO:0060078)4.16286643
35long-term synaptic potentiation (GO:0060291)4.14529179
36positive regulation of synapse maturation (GO:0090129)4.13635673
37G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)4.13098399
38neuron cell-cell adhesion (GO:0007158)4.12665060
39neurotransmitter secretion (GO:0007269)4.09267306
40positive regulation of membrane potential (GO:0045838)4.06010066
41positive regulation of neurotransmitter secretion (GO:0001956)4.02385114
42behavioral defense response (GO:0002209)3.95617206
43behavioral fear response (GO:0001662)3.95617206
44potassium ion homeostasis (GO:0055075)3.93271737
45gamma-aminobutyric acid signaling pathway (GO:0007214)3.91463837
46membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.90470264
47synaptic vesicle endocytosis (GO:0048488)3.87957392
48* regulation of dendritic spine morphogenesis (GO:0061001)3.84000775
49cellular potassium ion homeostasis (GO:0030007)3.81556072
50regulation of ARF protein signal transduction (GO:0032012)3.78422793
51cellular sodium ion homeostasis (GO:0006883)3.75378887
52regulation of glutamate secretion (GO:0014048)3.71809792
53fear response (GO:0042596)3.71542032
54neuron recognition (GO:0008038)3.68247970
55transmission of nerve impulse (GO:0019226)3.64917532
56* positive regulation of dendritic spine development (GO:0060999)3.63429515
57long term synaptic depression (GO:0060292)3.62774867
58layer formation in cerebral cortex (GO:0021819)3.62333359
59central nervous system myelination (GO:0022010)3.62124798
60axon ensheathment in central nervous system (GO:0032291)3.62124798
61positive regulation of neurotransmitter transport (GO:0051590)3.61875286
62G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.58395304
63negative regulation of synaptic transmission, GABAergic (GO:0032229)3.55495319
64regulation of female receptivity (GO:0045924)3.54873175
65chemosensory behavior (GO:0007635)3.54789331
66positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.52380545
67neuromuscular process controlling balance (GO:0050885)3.51130762
68response to histamine (GO:0034776)3.49917698
69regulation of synaptic transmission, glutamatergic (GO:0051966)3.49796040
70cytoskeletal anchoring at plasma membrane (GO:0007016)3.49321966
71regulation of vesicle fusion (GO:0031338)3.48641718
72cerebellar Purkinje cell layer development (GO:0021680)3.48085446
73regulation of Arp2/3 complex-mediated actin nucleation (GO:0034315)3.46159302
74potassium ion import (GO:0010107)3.45780311
75behavioral response to cocaine (GO:0048148)3.42718656
76negative regulation of amino acid transport (GO:0051956)3.42299564
77dicarboxylic acid transport (GO:0006835)3.39860472
78regulation of neurotransmitter secretion (GO:0046928)3.38484625
79learning (GO:0007612)3.38051238
80positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.34614583
81membrane depolarization (GO:0051899)3.32894435
82neurotransmitter transport (GO:0006836)3.32010240
83proline transport (GO:0015824)3.29086953
84axonal fasciculation (GO:0007413)3.28062754
85* regulation of dendritic spine development (GO:0060998)3.27202998
86acidic amino acid transport (GO:0015800)3.26951269
87activation of protein kinase A activity (GO:0034199)3.26501013
88cerebellar Purkinje cell differentiation (GO:0021702)3.25447371
89vesicle docking involved in exocytosis (GO:0006904)3.25396276
90sodium ion export (GO:0071436)3.24803489
91innervation (GO:0060384)3.23772683
92female mating behavior (GO:0060180)3.22993158
93positive regulation of synaptic transmission (GO:0050806)3.18706601
94* regulation of synaptic transmission (GO:0050804)3.17923899
95cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.17861677
96regulation of voltage-gated calcium channel activity (GO:1901385)3.17036406
97gamma-aminobutyric acid transport (GO:0015812)3.16024253
98synaptic transmission, dopaminergic (GO:0001963)3.15358236
99vesicle transport along microtubule (GO:0047496)3.15320213
100regulation of neurotransmitter levels (GO:0001505)3.12562279
101regulation of neurotransmitter transport (GO:0051588)3.11375063
102detection of calcium ion (GO:0005513)3.10375689
103regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.09906796
104response to amphetamine (GO:0001975)3.08865191
105regulation of synapse maturation (GO:0090128)3.08767548
106synaptic transmission (GO:0007268)3.05993936
107acid secretion (GO:0046717)3.05651221
108neuronal ion channel clustering (GO:0045161)3.00334306
109cell communication by electrical coupling (GO:0010644)2.99483082
110postsynaptic membrane organization (GO:0001941)2.99136728
111positive regulation of synaptic transmission, GABAergic (GO:0032230)2.96094488
112signal complex assembly (GO:0007172)2.94835782
113social behavior (GO:0035176)2.94753234
114intraspecies interaction between organisms (GO:0051703)2.94753234
115presynaptic membrane assembly (GO:0097105)2.94501315
116auditory behavior (GO:0031223)2.93750558
117NADH metabolic process (GO:0006734)2.93708670
118* dendritic spine organization (GO:0097061)2.93469180
119neuromuscular process (GO:0050905)2.92521452
120regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.92173875
121L-glutamate transport (GO:0015813)2.92016497
122synaptic vesicle transport (GO:0048489)2.91732850
123establishment of synaptic vesicle localization (GO:0097480)2.91732850
124regulation of oxidative phosphorylation (GO:0002082)2.88655065
125serotonin metabolic process (GO:0042428)2.87763754
126phosphorelay signal transduction system (GO:0000160)2.86935272
127vesicle docking (GO:0048278)2.86851483
128regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)2.85218507
129regulation of exocytosis (GO:0017157)2.78251783
130primary amino compound metabolic process (GO:1901160)2.76456230
131regulation of sensory perception (GO:0051931)2.72477173
132regulation of sensory perception of pain (GO:0051930)2.72477173
133signal release (GO:0023061)2.68773481
134nucleoside diphosphate biosynthetic process (GO:0009133)2.67947941
135mating behavior (GO:0007617)2.65619525

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.52120129
2GBX2_23144817_ChIP-Seq_PC3_Human3.60694237
3* SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.29504686
4JARID2_20064375_ChIP-Seq_MESCs_Mouse3.28324914
5TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.28190680
6* RARB_27405468_Chip-Seq_BRAIN_Mouse3.24582262
7* SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.17943030
8REST_21632747_ChIP-Seq_MESCs_Mouse2.96542616
9* SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.84576101
10* EZH2_18974828_ChIP-Seq_MESCs_Mouse2.83512850
11* RNF2_18974828_ChIP-Seq_MESCs_Mouse2.83512850
12JARID2_20075857_ChIP-Seq_MESCs_Mouse2.81260714
13LXR_22292898_ChIP-Seq_THP-1_Human2.74798654
14* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.64863564
15* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.61243824
16SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.58231796
17* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.56399377
18DROSHA_22980978_ChIP-Seq_HELA_Human2.53417450
19IKZF1_21737484_ChIP-ChIP_HCT116_Human2.50689084
20EZH2_27304074_Chip-Seq_ESCs_Mouse2.47017683
21REST_18959480_ChIP-ChIP_MESCs_Mouse2.40546416
22MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.34066542
23SUZ12_27294783_Chip-Seq_ESCs_Mouse2.31671749
24EED_16625203_ChIP-ChIP_MESCs_Mouse2.30580612
25RNF2_27304074_Chip-Seq_ESCs_Mouse2.28971702
26SRY_22984422_ChIP-ChIP_TESTIS_Rat2.27258668
27EZH2_27294783_Chip-Seq_ESCs_Mouse2.25336233
28SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse2.06340414
29ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.05099287
30TET1_21451524_ChIP-Seq_MESCs_Mouse1.98275964
31EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.94432489
32ERG_21242973_ChIP-ChIP_JURKAT_Human1.79869993
33ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.79249131
34CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.77813633
35CTBP1_25329375_ChIP-Seq_LNCAP_Human1.77758336
36P68_20966046_ChIP-Seq_HELA_Human1.75740911
37PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.74837174
38NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.72136412
39CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.70967949
40SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.67903800
41CTBP2_25329375_ChIP-Seq_LNCAP_Human1.67323182
42ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.66227964
43SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.65458072
44* TET1_21490601_ChIP-Seq_MESCs_Mouse1.65088094
45SMAD4_21799915_ChIP-Seq_A2780_Human1.64048237
46SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.62067780
47AR_21572438_ChIP-Seq_LNCaP_Human1.61369797
48* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.59580467
49UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.54544543
50* SMC4_20622854_ChIP-Seq_HELA_Human1.50409683
51* NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.50342072
52* RACK7_27058665_Chip-Seq_MCF-7_Human1.45778020
53TAF15_26573619_Chip-Seq_HEK293_Human1.45685974
54CREB1_26743006_Chip-Seq_LNCaP_Human1.45161983
55ESR2_21235772_ChIP-Seq_MCF-7_Human1.42766907
56RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.42572839
57RARG_19884340_ChIP-ChIP_MEFs_Mouse1.42147905
58ZNF274_21170338_ChIP-Seq_K562_Hela1.37748426
59P300_19829295_ChIP-Seq_ESCs_Human1.36355457
60ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.35713039
61SA1_27219007_Chip-Seq_ERYTHROID_Human1.34719152
62* RING1B_27294783_Chip-Seq_ESCs_Mouse1.33951627
63NR3C1_23031785_ChIP-Seq_PC12_Mouse1.32957601
64ZFP57_27257070_Chip-Seq_ESCs_Mouse1.31660771
65SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.31321820
66PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.29675076
67SMAD3_21741376_ChIP-Seq_EPCs_Human1.28815402
68GATA3_20176728_ChIP-ChIP_TSCs_Mouse1.28797325
69PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.28653787
70ZFP281_27345836_Chip-Seq_ESCs_Mouse1.28513689
71CTCF_27219007_Chip-Seq_ERYTHROID_Human1.28019250
72DNAJC2_21179169_ChIP-ChIP_NT2_Human1.26756853
73AR_25329375_ChIP-Seq_VCAP_Human1.25866670
74PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.25728332
75GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.25665481
76* SETDB1_19884255_ChIP-Seq_MESCs_Mouse1.23551283
77SOX2_21211035_ChIP-Seq_LN229_Gbm1.23327148
78GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.22400129
79TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.21557881
80AR_19668381_ChIP-Seq_PC3_Human1.17865824
81CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.17692934
82TOP2B_26459242_ChIP-Seq_MCF-7_Human1.17615665
83* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.17366986
84GATA1_26923725_Chip-Seq_HPCs_Mouse1.17155421
85RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.16888948
86WT1_25993318_ChIP-Seq_PODOCYTE_Human1.16801742
87* SA1_27219007_Chip-Seq_Bcells_Human1.15910025
88VDR_22108803_ChIP-Seq_LS180_Human1.15900333
89KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.15587876
90KDM2B_26808549_Chip-Seq_DND41_Human1.15203164
91* ZNF263_19887448_ChIP-Seq_K562_Human1.14967979
92* KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.14904870
93TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.14213298
94STAT3_23295773_ChIP-Seq_U87_Human1.13585507
95* SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.13432694
96PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.13217673
97TP53_16413492_ChIP-PET_HCT116_Human1.12941964
98SOX3_22085726_ChIP-Seq_MUSCLE_Mouse1.11676277
99BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.11320547
100SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.11144340
101ELF1_20517297_ChIP-Seq_JURKAT_Human1.10721786
102* RING1B_27294783_Chip-Seq_NPCs_Mouse1.10558031
103* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.09321947
104P53_22127205_ChIP-Seq_FIBROBLAST_Human1.09241303
105PRDM14_20953172_ChIP-Seq_ESCs_Human1.08521715
106RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.07621425
107OCT4_19829295_ChIP-Seq_ESCs_Human1.07541547
108GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.07089642
109ELK3_25401928_ChIP-Seq_HUVEC_Human1.06895246
110CDX2_20551321_ChIP-Seq_CACO-2_Human1.06631030
111CTCF_20526341_ChIP-Seq_ESCs_Human1.06524031
112TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.06046415
113OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.06029383
114JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse1.05814465
115FUS_26573619_Chip-Seq_HEK293_Human1.05661166
116* ZFP281_18757296_ChIP-ChIP_E14_Mouse1.05585519
117BCOR_27268052_Chip-Seq_Bcells_Human1.03634276
118RARA_24833708_ChIP-Seq_LIVER_Mouse1.03523099
119MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.02965382
120SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.02622886
121TCF4_23295773_ChIP-Seq_U87_Human1.02100834
122SMAD_19615063_ChIP-ChIP_OVARY_Human1.01567778
123BMI1_23680149_ChIP-Seq_NPCS_Mouse1.01291639
124* KDM2B_26808549_Chip-Seq_K562_Human1.01135765
125PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.00722854
126SMAD3_21741376_ChIP-Seq_HESCs_Human1.00446620
127MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.99611839
128CBX2_27304074_Chip-Seq_ESCs_Mouse0.99382280
129STAT3_19079543_ChIP-ChIP_MESCs_Mouse0.99333996
130ZNF217_24962896_ChIP-Seq_MCF-7_Human0.98489475
131PIAS1_25552417_ChIP-Seq_VCAP_Human0.98142953
132UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.98105259
133SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.97120252
134ARNT_22903824_ChIP-Seq_MCF-7_Human0.97067409
135* FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.96793934
136YAP1_20516196_ChIP-Seq_MESCs_Mouse0.96029261
137MYC_19915707_ChIP-ChIP_AK7_Human0.94250188
138RXR_22108803_ChIP-Seq_LS180_Human0.94111015
139OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.93920150
140THAP11_20581084_ChIP-Seq_MESCs_Mouse0.93625673
141KLF4_19829295_ChIP-Seq_ESCs_Human0.93147169
142RUNX2_22187159_ChIP-Seq_PCA_Human0.92301328
143TCF7_22412390_ChIP-Seq_EML_Mouse0.91882177
144TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.91838944
145JUN_21703547_ChIP-Seq_K562_Human0.91766380
146BCL6_27268052_Chip-Seq_Bcells_Human0.91551943
147NR3C1_21868756_ChIP-Seq_MCF10A_Human0.91405201
148SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.90608421
149CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.90056396
150ETS1_21867929_ChIP-Seq_TH2_Mouse0.89938173
151THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.88946539
152SMAD3_21741376_ChIP-Seq_ESCs_Human0.88902468
153AHR_22903824_ChIP-Seq_MCF-7_Human0.88453079
154CTCF_27219007_Chip-Seq_Bcells_Human0.88109806
155TP53_18474530_ChIP-ChIP_U2OS_Human0.87785531
156RNF2_27304074_Chip-Seq_NSC_Mouse0.86340181
157TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.85966517
158BCAT_22108803_ChIP-Seq_LS180_Human0.85431972
159SMAD4_21741376_ChIP-Seq_HESCs_Human0.85366938
160POU3F2_20337985_ChIP-ChIP_501MEL_Human0.85204264
161CDX2_19796622_ChIP-Seq_MESCs_Mouse0.83171923

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity7.77403368
2MP0003880_abnormal_central_pattern5.86596035
3* MP0003635_abnormal_synaptic_transmissio4.50064535
4MP0004270_analgesia3.81407738
5MP0002063_abnormal_learning/memory/cond3.77417601
6MP0009745_abnormal_behavioral_response3.73978817
7MP0002822_catalepsy3.46823562
8MP0002064_seizures3.28265901
9MP0001968_abnormal_touch/_nociception3.03709408
10MP0002572_abnormal_emotion/affect_behav3.01051632
11MP0009046_muscle_twitch2.67936172
12MP0002272_abnormal_nervous_system2.65446216
13MP0001501_abnormal_sleep_pattern2.60244479
14MP0002736_abnormal_nociception_after2.59043227
15MP0001486_abnormal_startle_reflex2.51929711
16MP0001440_abnormal_grooming_behavior2.32837894
17MP0002734_abnormal_mechanical_nocicepti2.26667667
18MP0003329_amyloid_beta_deposits2.09075215
19MP0002735_abnormal_chemical_nociception2.04998775
20MP0005423_abnormal_somatic_nervous2.02075329
21MP0009780_abnormal_chondrocyte_physiolo1.94708093
22MP0003123_paternal_imprinting1.81379630
23MP0002067_abnormal_sensory_capabilities1.79124833
24MP0001970_abnormal_pain_threshold1.77624420
25MP0002733_abnormal_thermal_nociception1.75565293
26MP0002909_abnormal_adrenal_gland1.70423777
27MP0004811_abnormal_neuron_physiology1.69551742
28MP0008569_lethality_at_weaning1.68068682
29MP0004858_abnormal_nervous_system1.66456468
30MP0005360_urolithiasis1.66210949
31MP0003879_abnormal_hair_cell1.64659517
32MP0005386_behavior/neurological_phenoty1.61400370
33MP0004924_abnormal_behavior1.61400370
34MP0002557_abnormal_social/conspecific_i1.61144155
35MP0000778_abnormal_nervous_system1.58806546
36MP0002184_abnormal_innervation1.56302604
37MP0001529_abnormal_vocalization1.49841201
38MP0004147_increased_porphyrin_level1.44832983
39MP0003787_abnormal_imprinting1.44190297
40MP0005646_abnormal_pituitary_gland1.40545932
41MP0000678_abnormal_parathyroid_gland1.38950301
42MP0002066_abnormal_motor_capabilities/c1.37216825
43MP0001984_abnormal_olfaction1.37005909
44MP0000955_abnormal_spinal_cord1.36935450
45MP0003633_abnormal_nervous_system1.35294012
46MP0003075_altered_response_to1.32966128
47MP0004885_abnormal_endolymph1.30123356
48MP0002882_abnormal_neuron_morphology1.27945296
49MP0002089_abnormal_postnatal_growth/wei1.25929484
50MP0001905_abnormal_dopamine_level1.25328837
51MP0002837_dystrophic_cardiac_calcinosis1.20385219
52MP0006276_abnormal_autonomic_nervous1.17046255
53MP0001188_hyperpigmentation1.16761505
54MP0003631_nervous_system_phenotype1.13564502
55MP0001502_abnormal_circadian_rhythm1.11816179
56MP0003183_abnormal_peptide_metabolism1.11401776
57MP0008872_abnormal_physiological_respon1.10331548
58MP0009379_abnormal_foot_pigmentation1.05863124
59MP0008874_decreased_physiological_sensi1.05737881
60MP0010234_abnormal_vibrissa_follicle1.04890257
61MP0002139_abnormal_hepatobiliary_system1.04463937
62MP0004510_myositis1.03992119
63MP0002249_abnormal_larynx_morphology1.03550678
64MP0002152_abnormal_brain_morphology1.01982819
65MP0000604_amyloidosis1.01703369
66MP0004145_abnormal_muscle_electrophysio1.01643076
67MP0005451_abnormal_body_composition0.97856368
68MP0001346_abnormal_lacrimal_gland0.96626874
69MP0005535_abnormal_body_temperature0.96126019
70MP0001666_abnormal_nutrient_absorption0.95854505
71MP0004484_altered_response_of0.94392021
72MP0002069_abnormal_eating/drinking_beha0.94317160
73MP0005409_darkened_coat_color0.92619805
74MP0008260_abnormal_autophagy0.90480132
75MP0005167_abnormal_blood-brain_barrier0.89534167
76MP0004142_abnormal_muscle_tone0.89451486
77MP0003172_abnormal_lysosome_physiology0.86650469
78MP0000681_abnormal_thyroid_gland0.86206177
79MP0000751_myopathy0.85605680
80MP0005645_abnormal_hypothalamus_physiol0.85502498
81MP0000566_synostosis0.83654970
82MP0000013_abnormal_adipose_tissue0.82836853
83MP0010329_abnormal_lipoprotein_level0.81409961
84MP0004085_abnormal_heartbeat0.79195586
85MP0002229_neurodegeneration0.79180094
86MP0001177_atelectasis0.77387281
87MP0001963_abnormal_hearing_physiology0.73991567
88MP0005394_taste/olfaction_phenotype0.73896509
89MP0005499_abnormal_olfactory_system0.73896509
90MP0010386_abnormal_urinary_bladder0.73665044
91MP0005085_abnormal_gallbladder_physiolo0.72784491
92MP0003632_abnormal_nervous_system0.72690018
93MP0005365_abnormal_bile_salt0.72000651
94MP0001664_abnormal_digestion0.71572867
95MP0004215_abnormal_myocardial_fiber0.70734648
96MP0006292_abnormal_olfactory_placode0.69811564
97MP0005058_abnormal_lysosome_morphology0.68389620
98MP0002876_abnormal_thyroid_physiology0.68147951
99MP0008961_abnormal_basal_metabolism0.67849623
100MP0001485_abnormal_pinna_reflex0.67103290
101MP0005551_abnormal_eye_electrophysiolog0.66976525
102MP0001765_abnormal_ion_homeostasis0.66629321
103MP0004742_abnormal_vestibular_system0.66318640
104MP0003283_abnormal_digestive_organ0.64754564
105MP0003690_abnormal_glial_cell0.63371451
106MP0001348_abnormal_lacrimal_gland0.61859219
107MP0009840_abnormal_foam_cell0.61373784
108MP0002234_abnormal_pharynx_morphology0.60984380
109MP0003122_maternal_imprinting0.60163571
110MP0000920_abnormal_myelination0.60144495
111MP0003634_abnormal_glial_cell0.59944239
112MP0001986_abnormal_taste_sensitivity0.59382383
113MP0005166_decreased_susceptibility_to0.58449553
114MP0006036_abnormal_mitochondrial_physio0.58246581
115MP0000462_abnormal_digestive_system0.55956140
116MP0002090_abnormal_vision0.55400174
117MP0004019_abnormal_vitamin_homeostasis0.55298715
118MP0005623_abnormal_meninges_morphology0.54907472
119MP0004233_abnormal_muscle_weight0.54747378
120MP0002752_abnormal_somatic_nervous0.54574411
121MP0000639_abnormal_adrenal_gland0.54381385
122MP0008875_abnormal_xenobiotic_pharmacok0.54000424
123MP0005332_abnormal_amino_acid0.53370782
124MP0002873_normal_phenotype0.51551159
125MP0000631_abnormal_neuroendocrine_gland0.51274675
126MP0003137_abnormal_impulse_conducting0.51058893
127MP0005595_abnormal_vascular_smooth0.47488612
128MP0003956_abnormal_body_size0.46945949
129MP0005171_absent_coat_pigmentation0.46384392
130MP0005187_abnormal_penis_morphology0.45565368

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)9.07329021
2Myokymia (HP:0002411)7.82438728
3Focal seizures (HP:0007359)6.35821122
4Visual hallucinations (HP:0002367)5.96634278
5Epileptic encephalopathy (HP:0200134)5.33192979
6Atonic seizures (HP:0010819)5.26162816
7Febrile seizures (HP:0002373)4.81772258
8Absence seizures (HP:0002121)4.73947843
9Dialeptic seizures (HP:0011146)4.42303437
10Hyperventilation (HP:0002883)4.24419705
11Generalized tonic-clonic seizures (HP:0002069)4.17102988
12Progressive cerebellar ataxia (HP:0002073)4.05634451
13Amblyopia (HP:0000646)3.97562947
14Action tremor (HP:0002345)3.89714100
15Broad-based gait (HP:0002136)3.78772317
16Poor eye contact (HP:0000817)3.71960193
17Impaired vibration sensation in the lower limbs (HP:0002166)3.66573221
18Cerebral inclusion bodies (HP:0100314)3.54278781
19Dysmetria (HP:0001310)3.49204602
20Abnormality of the lower motor neuron (HP:0002366)3.48299455
21Hyperthyroidism (HP:0000836)3.46712196
22Dysdiadochokinesis (HP:0002075)3.45994266
23Gaze-evoked nystagmus (HP:0000640)3.44163158
24Supranuclear gaze palsy (HP:0000605)3.43753228
25Truncus arteriosus (HP:0001660)3.42661729
26Anxiety (HP:0000739)3.38167846
27Depression (HP:0000716)3.30971559
28Impaired social interactions (HP:0000735)3.30915888
29Abnormal social behavior (HP:0012433)3.30915888
30Cerebral hypomyelination (HP:0006808)3.10359900
31Annular pancreas (HP:0001734)3.09646782
32Truncal ataxia (HP:0002078)2.98716210
33Impaired smooth pursuit (HP:0007772)2.93393610
34Neurofibrillary tangles (HP:0002185)2.90915130
35Postural instability (HP:0002172)2.88018895
36Urinary bladder sphincter dysfunction (HP:0002839)2.87280585
37Delusions (HP:0000746)2.86652462
38Neuronal loss in central nervous system (HP:0002529)2.79751235
39Stereotypic behavior (HP:0000733)2.79178231
40Tetraplegia (HP:0002445)2.76281291
41Excessive salivation (HP:0003781)2.74766353
42Drooling (HP:0002307)2.74766353
43Epileptiform EEG discharges (HP:0011182)2.72162947
44Hemiparesis (HP:0001269)2.71462807
45Ankle clonus (HP:0011448)2.71234411
46Upper limb amyotrophy (HP:0009129)2.67503136
47Distal upper limb amyotrophy (HP:0007149)2.67503136
48Scanning speech (HP:0002168)2.65252874
49Bradykinesia (HP:0002067)2.62862457
50Abnormal eating behavior (HP:0100738)2.62340547
51Abnormality of binocular vision (HP:0011514)2.59403816
52Diplopia (HP:0000651)2.59403816
53Urinary urgency (HP:0000012)2.55943274
54Status epilepticus (HP:0002133)2.55579813
55Impaired vibratory sensation (HP:0002495)2.53964148
56Clonus (HP:0002169)2.53696406
57Absent speech (HP:0001344)2.50412836
58Intention tremor (HP:0002080)2.46815678
59Abnormality of ocular smooth pursuit (HP:0000617)2.44581406
60Focal dystonia (HP:0004373)2.44205155
61EEG with generalized epileptiform discharges (HP:0011198)2.44160806
62Dysmetric saccades (HP:0000641)2.42731102
63Torticollis (HP:0000473)2.41969005
64Cholecystitis (HP:0001082)2.39674190
65Abnormal gallbladder physiology (HP:0012438)2.39674190
66Genetic anticipation (HP:0003743)2.32365183
67Peripheral hypomyelination (HP:0007182)2.32319934
68Generalized myoclonic seizures (HP:0002123)2.30824115
69Hand muscle atrophy (HP:0009130)2.29646447
70Ventricular fibrillation (HP:0001663)2.29192238
71Akinesia (HP:0002304)2.27758953
72Hypsarrhythmia (HP:0002521)2.25246684
73Papilledema (HP:0001085)2.23851728
74Progressive inability to walk (HP:0002505)2.23744374
75Spastic gait (HP:0002064)2.23204890
76Termporal pattern (HP:0011008)2.22229261
77Insidious onset (HP:0003587)2.22229261
78Inability to walk (HP:0002540)2.21727917
79Mutism (HP:0002300)2.21700921
80Lower limb asymmetry (HP:0100559)2.21618459
81Megalencephaly (HP:0001355)2.19379879
82Incomplete penetrance (HP:0003829)2.17357287
83Thickened helices (HP:0000391)2.15514953
84Bowel incontinence (HP:0002607)2.14284692
85Ankyloglossia (HP:0010296)2.14121792
86Hydroureter (HP:0000072)2.13129455
87Pointed chin (HP:0000307)2.12199005
88Hemiplegia (HP:0002301)2.11803626
89Spastic tetraparesis (HP:0001285)2.06147551
90Deep palmar crease (HP:0006191)2.04981917
91Rapidly progressive (HP:0003678)2.04869057
92Craniofacial dystonia (HP:0012179)2.03933857
93Resting tremor (HP:0002322)2.03256373
94Abnormal large intestine physiology (HP:0012700)2.02908719
95Abnormality of glycolysis (HP:0004366)2.02303836
96Global brain atrophy (HP:0002283)2.02184153
97Gait ataxia (HP:0002066)2.02086112
98Limb dystonia (HP:0002451)1.99195037
99Abnormality of aromatic amino acid family metabolism (HP:0004338)1.97042365
100Psychosis (HP:0000709)1.96881452
101Confusion (HP:0001289)1.96429108
102Testicular atrophy (HP:0000029)1.95637109
103Abnormality of glutamine family amino acid metabolism (HP:0010902)1.95343813
104Fetal akinesia sequence (HP:0001989)1.94684829
105Dementia (HP:0000726)1.93793977
106Lower limb muscle weakness (HP:0007340)1.92716247
107Choreoathetosis (HP:0001266)1.90388985
108Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.88734290
109Hyperparathyroidism (HP:0000843)1.88456361
110Bundle branch block (HP:0011710)1.88264143
111Athetosis (HP:0002305)1.86887899
112Abnormality of salivation (HP:0100755)1.86571500
113Obstructive sleep apnea (HP:0002870)1.84408977
114Achilles tendon contracture (HP:0001771)1.84066881
115Neonatal onset (HP:0003623)1.83694024
116Diminished motivation (HP:0000745)1.83328032
117Apathy (HP:0000741)1.82403018
118Lower limb amyotrophy (HP:0007210)1.81798914
119Protruding tongue (HP:0010808)1.81786216
120Amyotrophic lateral sclerosis (HP:0007354)1.81321829
121CNS hypomyelination (HP:0003429)1.80311895
122Growth hormone excess (HP:0000845)1.78916347
123Abnormality of the periventricular white matter (HP:0002518)1.78595654
124Abnormality of saccadic eye movements (HP:0000570)1.77404077
125Insomnia (HP:0100785)1.76005616
126Type II lissencephaly (HP:0007260)1.75400569
127Distal sensory impairment (HP:0002936)1.74284927
128Axonal loss (HP:0003447)1.74255610
129Rigidity (HP:0002063)1.73912695
130Deeply set eye (HP:0000490)1.73762613
131Degeneration of the lateral corticospinal tracts (HP:0002314)1.73666183
132Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.73666183
133Congenital malformation of the right heart (HP:0011723)1.73268270
134Double outlet right ventricle (HP:0001719)1.73268270
135Blue irides (HP:0000635)1.73240483
136Aplasia involving bones of the upper limbs (HP:0009823)1.72486689
137Aplasia of the phalanges of the hand (HP:0009802)1.72486689
138Aplasia involving bones of the extremities (HP:0009825)1.72486689
139Abnormality of the corticospinal tract (HP:0002492)1.71812555

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA46.42105061
2NTRK34.71051593
3MAP3K93.70601473
4RIPK43.70393463
5DAPK22.85845655
6KSR22.61425019
7MAP3K42.52021130
8MINK12.50579762
9ARAF2.17316041
10DAPK12.13301808
11PRKD32.13117717
12MAP2K72.07446324
13KSR12.00826483
14MAP3K132.00429599
15MAP3K121.92413000
16PAK61.92314898
17PLK21.90034175
18MAP2K41.73325386
19RIPK11.71406832
20CAMKK11.66552129
21BMPR21.65373773
22PTK2B1.63239736
23PNCK1.62400682
24GRK51.60453288
25MAP3K111.51606901
26RAF11.51452996
27PRPF4B1.49921373
28NTRK11.49674237
29CDK51.46996891
30FES1.40261493
31CASK1.38174538
32SIK21.37227746
33STK381.31144593
34MARK11.27586100
35NTRK21.27567816
36CDK191.26557687
37NME11.23309867
38PRKCG1.23230604
39TYRO31.19461264
40MAP3K21.18380345
41MST1R1.16559049
42PRKG21.16395240
43TESK11.13684757
44NME21.12049646
45TRIB31.08817504
46FGR1.05437420
47CAMK2B1.00069520
48TNIK0.98635747
49ICK0.95050532
50* CAMK2A0.94035912
51CAMK10.89476185
52IRAK30.88795909
53ERN10.88208980
54PINK10.86871848
55TAOK20.83036021
56CDK180.81928965
57CAMKK20.79720569
58CDK150.78900583
59EPHA20.77908675
60PHKG10.77494693
61PHKG20.77494693
62SMG10.76966106
63CDK140.75847869
64UHMK10.71345701
65PDK10.70757174
66STK110.69932773
67TAOK10.69782586
68GRK60.69578734
69CDK11A0.69442312
70SGK10.67852071
71PDPK10.67513602
72MAP3K10.66145740
73DYRK1A0.63311972
74LIMK10.60083822
75MAPK130.58796964
76OXSR10.57164781
77BRAF0.56941977
78DAPK30.56193025
79SGK2230.56058857
80SGK4940.56058857
81RET0.55756925
82MAP3K70.55265403
83TNK20.55192329
84MOS0.54699773
85DMPK0.54602564
86MAP2K10.54399594
87IRAK20.54146184
88PRKCH0.53934768
89PAK30.53325800
90BMX0.52858444
91FER0.49859531
92CAMK2D0.48067783
93LATS20.47569659
94MAPK110.45286931
95SCYL20.44547194
96MARK20.43109767
97MAP3K60.42697304
98MAP2K60.41998132
99NEK10.41194453
100CAMK2G0.41116776
101PAK10.40729533
102SGK20.40309600
103RPS6KA30.40214979
104PRKCZ0.40130533
105ALK0.38683125
106FYN0.38306736
107MET0.38292795
108MAPK100.38152947
109PRKCE0.38092516
110PTK20.37598573
111SIK30.36746354
112EEF2K0.36522013
113PRKD20.36039427
114ABL20.35681847
115SGK30.34938851
116CCNB10.34461165
117CAMK40.33841945
118AKT20.32084800
119TESK20.31201477
120PRKCQ0.30253157
121ROCK20.28510998
122AKT30.26628712
123* PRKCA0.25932233
124DDR20.25391184
125BRSK10.24992371
126LMTK20.23964801
127NEK60.23919424
128GRK70.22869156
129MAPK120.22455723

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.90014527
2Long-term potentiation_Homo sapiens_hsa047203.33102714
3Synaptic vesicle cycle_Homo sapiens_hsa047212.94054749
4Amphetamine addiction_Homo sapiens_hsa050312.89224233
5Olfactory transduction_Homo sapiens_hsa047402.88223883
6Circadian entrainment_Homo sapiens_hsa047132.87591530
7Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.82191271
8Glutamatergic synapse_Homo sapiens_hsa047242.78676781
9Morphine addiction_Homo sapiens_hsa050322.50899333
10GABAergic synapse_Homo sapiens_hsa047272.49566867
11Vitamin B6 metabolism_Homo sapiens_hsa007502.47674165
12Salivary secretion_Homo sapiens_hsa049702.47108122
13Dopaminergic synapse_Homo sapiens_hsa047282.25951329
14Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.23603501
15Gastric acid secretion_Homo sapiens_hsa049712.04496022
16Renin secretion_Homo sapiens_hsa049241.96108365
17Aldosterone synthesis and secretion_Homo sapiens_hsa049251.94198027
18Insulin secretion_Homo sapiens_hsa049111.92912620
19Oxytocin signaling pathway_Homo sapiens_hsa049211.87232433
20Long-term depression_Homo sapiens_hsa047301.86385506
21Cholinergic synapse_Homo sapiens_hsa047251.84087705
22Taste transduction_Homo sapiens_hsa047421.78990012
23* Calcium signaling pathway_Homo sapiens_hsa040201.78579728
24Cyanoamino acid metabolism_Homo sapiens_hsa004601.71255079
25Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.66495823
26Serotonergic synapse_Homo sapiens_hsa047261.61551388
27GnRH signaling pathway_Homo sapiens_hsa049121.60868768
282-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.58517152
29Collecting duct acid secretion_Homo sapiens_hsa049661.52096035
30Cocaine addiction_Homo sapiens_hsa050301.46868729
31Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.45141988
32Sulfur relay system_Homo sapiens_hsa041221.40099214
33Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.39920364
34Arginine and proline metabolism_Homo sapiens_hsa003301.38349708
35Gap junction_Homo sapiens_hsa045401.37692565
36Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.34498768
37cAMP signaling pathway_Homo sapiens_hsa040241.33540560
38Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.31873644
39Glioma_Homo sapiens_hsa052141.25125524
40Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.21382161
41cGMP-PKG signaling pathway_Homo sapiens_hsa040221.16493842
42* Phosphatidylinositol signaling system_Homo sapiens_hsa040701.14663836
43Estrogen signaling pathway_Homo sapiens_hsa049151.14067681
44Melanogenesis_Homo sapiens_hsa049161.11588408
45Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050141.09161698
46Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.07998454
47Fructose and mannose metabolism_Homo sapiens_hsa000511.07841861
48Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.04009686
49Cardiac muscle contraction_Homo sapiens_hsa042601.02472949
50Vascular smooth muscle contraction_Homo sapiens_hsa042701.01545813
51Oocyte meiosis_Homo sapiens_hsa041140.99857312
52Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.98966599
53Pancreatic secretion_Homo sapiens_hsa049720.98159122
54Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.95861701
55VEGF signaling pathway_Homo sapiens_hsa043700.95158264
56Type II diabetes mellitus_Homo sapiens_hsa049300.93647576
57Axon guidance_Homo sapiens_hsa043600.92876342
58ErbB signaling pathway_Homo sapiens_hsa040120.92024295
59Biosynthesis of amino acids_Homo sapiens_hsa012300.88270081
60Nitrogen metabolism_Homo sapiens_hsa009100.87820011
61Vibrio cholerae infection_Homo sapiens_hsa051100.86171942
62Phospholipase D signaling pathway_Homo sapiens_hsa040720.83343521
63Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.82835715
64Choline metabolism in cancer_Homo sapiens_hsa052310.81907845
65Phototransduction_Homo sapiens_hsa047440.81401452
66African trypanosomiasis_Homo sapiens_hsa051430.78867068
67Thyroid hormone synthesis_Homo sapiens_hsa049180.77731638
68Dorso-ventral axis formation_Homo sapiens_hsa043200.75085403
69Fat digestion and absorption_Homo sapiens_hsa049750.73600966
70Alzheimers disease_Homo sapiens_hsa050100.70952686
71Glucagon signaling pathway_Homo sapiens_hsa049220.70482740
72Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.67888323
73Phenylalanine metabolism_Homo sapiens_hsa003600.66007600
74Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.65636204
75MAPK signaling pathway_Homo sapiens_hsa040100.62303469
76Carbon metabolism_Homo sapiens_hsa012000.61537751
77Rap1 signaling pathway_Homo sapiens_hsa040150.59701716
78SNARE interactions in vesicular transport_Homo sapiens_hsa041300.59455560
79Dilated cardiomyopathy_Homo sapiens_hsa054140.58270288
80Fatty acid biosynthesis_Homo sapiens_hsa000610.56314173
81Carbohydrate digestion and absorption_Homo sapiens_hsa049730.55069374
82Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.53651796
83Neurotrophin signaling pathway_Homo sapiens_hsa047220.52777697
84Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.51663584
85Ras signaling pathway_Homo sapiens_hsa040140.50998902
86Pentose phosphate pathway_Homo sapiens_hsa000300.50767307
87Sphingolipid signaling pathway_Homo sapiens_hsa040710.50088037
88Non-small cell lung cancer_Homo sapiens_hsa052230.49366870
89Galactose metabolism_Homo sapiens_hsa000520.48677985
90Histidine metabolism_Homo sapiens_hsa003400.47252743
91Sulfur metabolism_Homo sapiens_hsa009200.45911526
92mTOR signaling pathway_Homo sapiens_hsa041500.45520050
93Thyroid hormone signaling pathway_Homo sapiens_hsa049190.44843490
94Bile secretion_Homo sapiens_hsa049760.44726273
95Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.44550271
96Prion diseases_Homo sapiens_hsa050200.43254665
97Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.39604711
98Alcoholism_Homo sapiens_hsa050340.39127755
99Type I diabetes mellitus_Homo sapiens_hsa049400.37210612
100Oxidative phosphorylation_Homo sapiens_hsa001900.36449607
101Wnt signaling pathway_Homo sapiens_hsa043100.36346903
102Renin-angiotensin system_Homo sapiens_hsa046140.35597721
103Endocytosis_Homo sapiens_hsa041440.35534283
104Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.34050931
105Pyruvate metabolism_Homo sapiens_hsa006200.32954098
106Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.32745405
107Glycerolipid metabolism_Homo sapiens_hsa005610.31396238
108Longevity regulating pathway - mammal_Homo sapiens_hsa042110.30007886
109* Inositol phosphate metabolism_Homo sapiens_hsa005620.29872034
110Protein digestion and absorption_Homo sapiens_hsa049740.29034110
111Circadian rhythm_Homo sapiens_hsa047100.27882749
112Chemokine signaling pathway_Homo sapiens_hsa040620.27557107
113Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.26977454
114Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.26749283
115PPAR signaling pathway_Homo sapiens_hsa033200.26313532
116Folate biosynthesis_Homo sapiens_hsa007900.26015395
117Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.25594717
118Vitamin digestion and absorption_Homo sapiens_hsa049770.25469374
119Mineral absorption_Homo sapiens_hsa049780.24982853
120Insulin signaling pathway_Homo sapiens_hsa049100.23548632
121Regulation of actin cytoskeleton_Homo sapiens_hsa048100.22217375
122Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.21959475
123Parkinsons disease_Homo sapiens_hsa050120.21161473
124Renal cell carcinoma_Homo sapiens_hsa052110.20743921
125Arginine biosynthesis_Homo sapiens_hsa002200.20172242
126Platelet activation_Homo sapiens_hsa046110.18608822
127Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.17637064
128Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.17215325

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