ITPKB

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this protein regulates inositol phosphate metabolism by phosphorylation of second messenger inositol 1,4,5-trisphosphate to Ins(1,3,4,5)P4. The activity of this encoded protein is responsible for regulating the levels of a large number of inositol polyphosphates that are important in cellular signaling. Both calcium/calmodulin and protein phosphorylation mechanisms control its activity. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of gamma-delta T cell activation (GO:0046645)4.84191715
2regulation of gamma-delta T cell differentiation (GO:0045586)4.69618921
3regulation of gamma-delta T cell activation (GO:0046643)4.47657702
4negative regulation of amyloid precursor protein catabolic process (GO:1902992)3.71496483
5regulation of interleukin-12 biosynthetic process (GO:0045075)3.66517977
6negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.62690888
7negative regulation of cell killing (GO:0031342)3.62690888
8antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.61060643
9antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.61060643
10regulation of ARF protein signal transduction (GO:0032012)3.57970243
11* positive thymic T cell selection (GO:0045059)3.53297784
12positive regulation of histone deacetylation (GO:0031065)3.51744000
13endothelial cell chemotaxis (GO:0035767)3.42486568
14negative T cell selection (GO:0043383)3.36674796
15positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.34590283
16vascular endothelial growth factor signaling pathway (GO:0038084)3.32115988
17L-amino acid import (GO:0043092)3.30408917
18tolerance induction (GO:0002507)3.28980763
19cellular response to vascular endothelial growth factor stimulus (GO:0035924)3.27055428
20* positive T cell selection (GO:0043368)3.26065310
21modulation by symbiont of host defense response (GO:0052031)3.22485140
22modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.22485140
23modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.22485140
24positive regulation by organism of defense response of other organism involved in symbiotic interact3.22485140
25modulation by symbiont of host immune response (GO:0052553)3.22485140
26positive regulation by symbiont of host defense response (GO:0052509)3.22485140
27* thymic T cell selection (GO:0045061)3.21493579
28negative thymic T cell selection (GO:0045060)3.20074089
29activated T cell proliferation (GO:0050798)3.16744493
30antigen processing and presentation of endogenous antigen (GO:0019883)3.16374933
31* T cell selection (GO:0045058)3.15498989
32JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)3.08634927
33negative regulation of lymphocyte mediated immunity (GO:0002707)3.08260478
34regulation of Rap GTPase activity (GO:0032317)3.06920397
35negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.05217113
36signal complex assembly (GO:0007172)3.04715026
37regulation of T-helper 2 cell differentiation (GO:0045628)3.04591597
38sodium ion export (GO:0071436)3.04041623
39negative regulation of type 2 immune response (GO:0002829)2.96654582
40negative regulation of T-helper cell differentiation (GO:0045623)2.96522806
41negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.96522806
42antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.96436208
43negative regulation of leukocyte mediated immunity (GO:0002704)2.96242929
44cellular response to interleukin-15 (GO:0071350)2.94316534
45response to muramyl dipeptide (GO:0032495)2.89797847
46negative regulation of T cell mediated immunity (GO:0002710)2.87656439
47cellular potassium ion homeostasis (GO:0030007)2.84501466
48regulation of B cell receptor signaling pathway (GO:0050855)2.82793497
49central nervous system myelination (GO:0022010)2.81978115
50axon ensheathment in central nervous system (GO:0032291)2.81978115
51regulation of T cell tolerance induction (GO:0002664)2.79745755
52detection of other organism (GO:0098543)2.77926461
53melanin metabolic process (GO:0006582)2.75848358
54interferon-gamma production (GO:0032609)2.73099065
55negative regulation of bone resorption (GO:0045779)2.71811089
56detection of bacterium (GO:0016045)2.69905476
57synaptic vesicle exocytosis (GO:0016079)2.69054130
58regulation of p38MAPK cascade (GO:1900744)2.68759609
59apoptotic cell clearance (GO:0043277)2.66378437
60positive regulation of p38MAPK cascade (GO:1900745)2.64985978
61positive regulation of tolerance induction (GO:0002645)2.64788797
62protein localization to endosome (GO:0036010)2.62298016
63synaptic vesicle docking involved in exocytosis (GO:0016081)2.61952746
64positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.61782931
65negative regulation of stress fiber assembly (GO:0051497)2.61520055
66amino acid import (GO:0043090)2.60889382
67modulation by symbiont of host cellular process (GO:0044068)2.60458691
68peptidyl-tyrosine autophosphorylation (GO:0038083)2.59283244
69cell migration involved in sprouting angiogenesis (GO:0002042)2.57718651
70regulation of beta-amyloid formation (GO:1902003)2.56263050
71regulation of synaptic vesicle exocytosis (GO:2000300)2.55123387
72activation of protein kinase A activity (GO:0034199)2.48825325
73coronary vasculature morphogenesis (GO:0060977)2.47206546
74melanin biosynthetic process (GO:0042438)2.47134352
75synaptic vesicle maturation (GO:0016188)2.47119024
76regulation of amyloid precursor protein catabolic process (GO:1902991)2.44656351
77positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.43662593
78regulation of ARF GTPase activity (GO:0032312)2.41774199
79relaxation of cardiac muscle (GO:0055119)2.41748082
80potassium ion import (GO:0010107)2.39559734
81growth hormone receptor signaling pathway (GO:0060396)2.37611582
82cellular response to reactive nitrogen species (GO:1902170)2.36471736
83mast cell activation (GO:0045576)2.35643218
84activation of JUN kinase activity (GO:0007257)2.35556323
85response to interleukin-15 (GO:0070672)2.35341437
86T cell receptor signaling pathway (GO:0050852)2.35066010
87regulation of interferon-beta biosynthetic process (GO:0045357)2.34847551
88positive regulation of granulocyte differentiation (GO:0030854)2.34648015
89positive regulation of cellular amide metabolic process (GO:0034250)2.34204020
90negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.33887090
91antigen processing and presentation via MHC class Ib (GO:0002475)2.33436061
92mannose metabolic process (GO:0006013)2.32739864
93regulation of type 2 immune response (GO:0002828)2.32714484
94cytoplasmic mRNA processing body assembly (GO:0033962)2.32674313
95regulation of tolerance induction (GO:0002643)2.32491256
96NIK/NF-kappaB signaling (GO:0038061)2.31827109
97regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition 2.31773069
98negative regulation of erythrocyte differentiation (GO:0045647)2.31095296
99cellular response to epinephrine stimulus (GO:0071872)2.30270379
100regulation of macrophage cytokine production (GO:0010935)2.30078960
101negative regulation of alpha-beta T cell activation (GO:0046636)2.29569623
102leukocyte aggregation (GO:0070486)2.29423110
103positive regulation of Rap GTPase activity (GO:0032854)2.28096286
104macrophage activation involved in immune response (GO:0002281)2.27882144
105response to fluid shear stress (GO:0034405)2.27844886
106response to laminar fluid shear stress (GO:0034616)2.27801469
107regulation of isotype switching to IgG isotypes (GO:0048302)2.27736518
108detection of external biotic stimulus (GO:0098581)2.27503192
109regulation of alpha-beta T cell proliferation (GO:0046640)2.27369272
110mucosal-associated lymphoid tissue development (GO:0048537)2.27184842
111Peyers patch development (GO:0048541)2.27184842
112positive regulation of protein deacetylation (GO:0090312)2.26118998
113plasma membrane repair (GO:0001778)2.25577863
114cellular response to type I interferon (GO:0071357)2.25505647
115type I interferon signaling pathway (GO:0060337)2.25505647
116myeloid cell activation involved in immune response (GO:0002275)2.24951775
117locomotory exploration behavior (GO:0035641)2.24940686
118negative regulation of adaptive immune response based on somatic recombination of immune receptors b2.24699092
119T cell migration (GO:0072678)2.24423150
120leukocyte cell-cell adhesion (GO:0007159)2.23787280
121positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.23749982
122positive regulation of natural killer cell differentiation (GO:0032825)2.23602537
123natural killer cell differentiation (GO:0001779)2.23515973
124regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.20188458
125substrate-dependent cell migration (GO:0006929)2.19090390
126positive regulation of B cell differentiation (GO:0045579)2.18312777
127heterotypic cell-cell adhesion (GO:0034113)2.16930831
128I-kappaB phosphorylation (GO:0007252)2.16323621
129retrograde transport, vesicle recycling within Golgi (GO:0000301)2.16248732
130regulation of histone deacetylation (GO:0031063)2.16043654
131antigen receptor-mediated signaling pathway (GO:0050851)2.16030791
132establishment of endothelial barrier (GO:0061028)2.15525505
133negative regulation of bone remodeling (GO:0046851)2.15412403
134cell adhesion mediated by integrin (GO:0033627)2.14789254
135positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.12710711
136B cell receptor signaling pathway (GO:0050853)2.12110022
137germinal center formation (GO:0002467)2.11896693
138regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.11284023
139morphogenesis of an endothelium (GO:0003159)2.10937156
140endothelial tube morphogenesis (GO:0061154)2.10937156
141interleukin-1-mediated signaling pathway (GO:0070498)2.10853617
142cellular response to nicotine (GO:0071316)2.10080644
143negative regulation of interleukin-12 production (GO:0032695)2.09812122
144response to type I interferon (GO:0034340)2.09180201
145JAK-STAT cascade (GO:0007259)2.08671602
146T cell costimulation (GO:0031295)2.07354959
147positive regulation of macrophage cytokine production (GO:0060907)2.07211754
148cortical actin cytoskeleton organization (GO:0030866)2.07186436
149regulation of B cell differentiation (GO:0045577)2.06144728
150cellular response to growth hormone stimulus (GO:0071378)2.05740941
151lymph vessel development (GO:0001945)2.05384258
152establishment of protein localization to Golgi (GO:0072600)2.04646694
153vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.04480290
154cellular extravasation (GO:0045123)2.03918916
155regulation of cholesterol storage (GO:0010885)2.03799373
156patterning of blood vessels (GO:0001569)2.02908376
157surfactant homeostasis (GO:0043129)2.02637520

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* STAT6_20620947_ChIP-Seq_CD4_POS_T_Human4.39655192
2FOXP3_17237761_ChIP-ChIP_TREG_Mouse4.11264739
3NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.39686122
4TP63_17297297_ChIP-ChIP_HaCaT_Human2.83098078
5IRF8_22096565_ChIP-ChIP_GC-B_Human2.76466344
6RUNX_20019798_ChIP-Seq_JUKART_Human2.49820624
7STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.42440987
8* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.36034992
9EGR1_19374776_ChIP-ChIP_THP-1_Human2.27995777
10* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.26145651
11BP1_19119308_ChIP-ChIP_Hs578T_Human2.17289312
12* KDM2B_26808549_Chip-Seq_SUP-B15_Human2.15729645
13GATA1_22025678_ChIP-Seq_K562_Human2.13006829
14TCF7_22412390_ChIP-Seq_EML_Mouse2.08572375
15STAT6_21828071_ChIP-Seq_BEAS2B_Human2.06121950
16EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.04647734
17NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.99519421
18IRF8_27001747_Chip-Seq_BMDM_Mouse1.98155691
19* KDM2B_26808549_Chip-Seq_DND41_Human1.95730232
20MYC_22102868_ChIP-Seq_BL_Human1.93024071
21MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.92556834
22GATA2_21666600_ChIP-Seq_HMVEC_Human1.88770012
23IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.85762182
24* KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.81568596
25* MAF_26560356_Chip-Seq_TH1_Human1.77032349
26SCL_19346495_ChIP-Seq_HPC-7_Human1.76186478
27SPI1_23127762_ChIP-Seq_K562_Human1.75343899
28STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.71263516
29MYB_26560356_Chip-Seq_TH2_Human1.67996431
30* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.64099708
31VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.63122444
32VDR_21846776_ChIP-Seq_THP-1_Human1.62766333
33UTX_26944678_Chip-Seq_JUKART_Human1.62578323
34ELK3_25401928_ChIP-Seq_HUVEC_Human1.62075929
35MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.61455560
36RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.59824562
37* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.57979299
38IKZF1_21737484_ChIP-ChIP_HCT116_Human1.57976183
39TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.56492715
40MYB_21317192_ChIP-Seq_ERMYB_Mouse1.54361249
41FOXO3_23340844_ChIP-Seq_DLD1_Human1.53811175
42EZH2_22144423_ChIP-Seq_EOC_Human1.52791583
43Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.51148799
44IRF8_21731497_ChIP-ChIP_J774_Mouse1.50262907
45ESR2_21235772_ChIP-Seq_MCF-7_Human1.49771197
46VDR_24763502_ChIP-Seq_THP-1_Human1.49238475
47SMAD_19615063_ChIP-ChIP_OVARY_Human1.48717336
48RARB_27405468_Chip-Seq_BRAIN_Mouse1.48464248
49* MAF_26560356_Chip-Seq_TH2_Human1.46945376
50THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.45709222
51CLOCK_20551151_ChIP-Seq_293T_Human1.45333137
52TBX20_22080862_ChIP-Seq_HEART_Mouse1.44071395
53TBX20_22328084_ChIP-Seq_HEART_Mouse1.44071395
54* KDM2B_26808549_Chip-Seq_JURKAT_Human1.42110535
55MYB_26560356_Chip-Seq_TH1_Human1.41667832
56ESR1_21235772_ChIP-Seq_MCF-7_Human1.39869256
57* TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.38675982
58DNAJC2_21179169_ChIP-ChIP_NT2_Human1.37499849
59BRD4_27068464_Chip-Seq_AML-cells_Mouse1.36543992
60* SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.35495642
61GATA1_19941826_ChIP-Seq_K562_Human1.34321739
62* GATA3_27048872_Chip-Seq_THYMUS_Human1.34217465
63ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.33436684
64KDM2B_26808549_Chip-Seq_K562_Human1.32872860
65* SOX9_24532713_ChIP-Seq_HFSC_Mouse1.31033224
66* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.29150678
67KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.25732643
68IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.25405378
69ZNF217_24962896_ChIP-Seq_MCF-7_Human1.24299307
70VDR_24787735_ChIP-Seq_THP-1_Human1.24214758
71TRIM28_21343339_ChIP-Seq_HEK293_Human1.22944642
72ZFP281_27345836_Chip-Seq_ESCs_Mouse1.20593004
73STAT4_19710469_ChIP-ChIP_TH1__Mouse1.20320358
74LXR_22292898_ChIP-Seq_THP-1_Human1.17147752
75ZFP281_18757296_ChIP-ChIP_E14_Mouse1.17124091
76NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.15708981
77GATA2_19941826_ChIP-Seq_K562_Human1.15059053
78RUNX1_22412390_ChIP-Seq_EML_Mouse1.14341785
79RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.13934352
80* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.13156087
81PPAR_26484153_Chip-Seq_NCI-H1993_Human1.13079747
82RARG_19884340_ChIP-ChIP_MEFs_Mouse1.11625583
83NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.10795356
84TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.10663091
85RUNX1_27514584_Chip-Seq_MCF-7_Human1.10641708
86RNF2_27304074_Chip-Seq_ESCs_Mouse1.10440674
87EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.08692174
88DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.08058203
89* MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.07250574
90HIF1A_21447827_ChIP-Seq_MCF-7_Human1.05822789
91SMC4_20622854_ChIP-Seq_HELA_Human1.05734968
92* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.05204390
93CDX2_19796622_ChIP-Seq_MESCs_Mouse1.05103722
94GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.04984125
95* GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.04959097
96PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.04909002
97* PU_27001747_Chip-Seq_BMDM_Mouse1.03576490
98* FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.03467621
99EP300_21415370_ChIP-Seq_HL-1_Mouse1.02539813
100NFIB_24661679_ChIP-Seq_LUNG_Mouse1.02362840
101GATA1_19941827_ChIP-Seq_MEL_Mouse1.02059592
102SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.01987169
103* CTCF_27219007_Chip-Seq_ERYTHROID_Human1.01820363
104BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.00981451
105SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.99678877
106AHR_22903824_ChIP-Seq_MCF-7_Human0.99446016
107P300_27058665_Chip-Seq_ZR-75-30cells_Human0.99177323
108RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.99125209
109WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.98087678
110* RACK7_27058665_Chip-Seq_MCF-7_Human0.97924189
111LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.97515999
112* PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.97111097
113* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.96820823
114DROSHA_22980978_ChIP-Seq_HELA_Human0.96383123
115* SA1_27219007_Chip-Seq_ERYTHROID_Human0.93839860
116SUZ12_27294783_Chip-Seq_ESCs_Mouse0.93392188
117* SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.91814454
118* PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.91171487
119LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.90689730
120RXR_22108803_ChIP-Seq_LS180_Human0.90319788
121* JARID2_20064375_ChIP-Seq_MESCs_Mouse0.89864774
122SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.89132561
123SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.89132561
124NCOR1_26117541_ChIP-Seq_K562_Human0.88790057
125WT1_25993318_ChIP-Seq_PODOCYTE_Human0.88771601
126* JARID2_20075857_ChIP-Seq_MESCs_Mouse0.86926679
127EZH2_27294783_Chip-Seq_ESCs_Mouse0.86865624
128BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.85948607
129* PU.1_20513432_ChIP-Seq_Bcells_Mouse0.85169375
130* SUZ12_18692474_ChIP-Seq_MESCs_Mouse0.84977886
131* OCT4_19829295_ChIP-Seq_ESCs_Human0.84636138

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003300_gastrointestinal_ulcer3.74833271
2MP0003303_peritoneal_inflammation3.16185341
3MP0003690_abnormal_glial_cell3.02094038
4MP0004510_myositis2.89780008
5MP0004381_abnormal_hair_follicle2.89042072
6MP0004859_abnormal_synaptic_plasticity2.85702101
7MP0009278_abnormal_bone_marrow2.43550575
8MP0002166_altered_tumor_susceptibility2.28220338
9MP0004947_skin_inflammation2.27257977
10MP0008961_abnormal_basal_metabolism2.18306331
11* MP0003763_abnormal_thymus_physiology2.13416419
12MP0005387_immune_system_phenotype2.13015705
13MP0001790_abnormal_immune_system2.13015705
14MP0003828_pulmonary_edema2.11950851
15MP0003045_fibrosis2.09261603
16MP0000685_abnormal_immune_system2.08946835
17MP0003329_amyloid_beta_deposits2.02506877
18MP0008569_lethality_at_weaning2.00777199
19MP0005171_absent_coat_pigmentation2.00466940
20MP0003724_increased_susceptibility_to1.98976929
21MP0000569_abnormal_digit_pigmentation1.98026570
22MP0004084_abnormal_cardiac_muscle1.97998952
23MP0000920_abnormal_myelination1.97773311
24MP0005423_abnormal_somatic_nervous1.97332432
25MP0003566_abnormal_cell_adhesion1.96670611
26MP0001879_abnormal_lymphatic_vessel1.94952122
27MP0002877_abnormal_melanocyte_morpholog1.92329936
28MP0005075_abnormal_melanosome_morpholog1.91959743
29MP0005167_abnormal_blood-brain_barrier1.89509746
30MP0005000_abnormal_immune_tolerance1.81584390
31MP0003436_decreased_susceptibility_to1.79243262
32MP0002006_tumorigenesis1.74066609
33MP0005671_abnormal_response_to1.73658650
34MP0001835_abnormal_antigen_presentation1.73175191
35* MP0001800_abnormal_humoral_immune1.72094353
36MP0002064_seizures1.69043442
37MP0005409_darkened_coat_color1.62100693
38MP0000015_abnormal_ear_pigmentation1.60775225
39MP0003635_abnormal_synaptic_transmissio1.59509597
40MP0003705_abnormal_hypodermis_morpholog1.59129180
41MP0004130_abnormal_muscle_cell1.58869228
42MP0009780_abnormal_chondrocyte_physiolo1.58719396
43MP0010368_abnormal_lymphatic_system1.58176472
44MP0000604_amyloidosis1.56375877
45* MP0002723_abnormal_immune_serum1.55593806
46* MP0002452_abnormal_antigen_presenting1.54192166
47MP0008260_abnormal_autophagy1.53276643
48MP0005076_abnormal_cell_differentiation1.53182609
49MP0003172_abnormal_lysosome_physiology1.50169890
50* MP0002420_abnormal_adaptive_immunity1.49598527
51* MP0001819_abnormal_immune_cell1.48887175
52MP0005058_abnormal_lysosome_morphology1.48882532
53MP0002419_abnormal_innate_immunity1.47644127
54MP0001851_eye_inflammation1.46986123
55MP0005670_abnormal_white_adipose1.46901858
56MP0003279_aneurysm1.45429886
57MP0002405_respiratory_system_inflammati1.40721846
58MP0003136_yellow_coat_color1.39427929
59MP0004036_abnormal_muscle_relaxation1.35477665
60MP0002063_abnormal_learning/memory/cond1.34126984
61MP0003075_altered_response_to1.34125208
62* MP0005025_abnormal_response_to1.33850571
63MP0004808_abnormal_hematopoietic_stem1.31466319
64MP0005464_abnormal_platelet_physiology1.31287844
65MP0001853_heart_inflammation1.31130698
66MP0003091_abnormal_cell_migration1.30711836
67MP0004885_abnormal_endolymph1.30049755
68MP0002998_abnormal_bone_remodeling1.29527040
69MP0010155_abnormal_intestine_physiology1.29335388
70MP0001873_stomach_inflammation1.27786958
71MP0002693_abnormal_pancreas_physiology1.26168830
72MP0001501_abnormal_sleep_pattern1.25373237
73MP0003183_abnormal_peptide_metabolism1.25186598
74MP0010630_abnormal_cardiac_muscle1.24491808
75MP0001958_emphysema1.23168753
76MP0001533_abnormal_skeleton_physiology1.22195342
77* MP0002398_abnormal_bone_marrow1.21400542
78MP0004185_abnormal_adipocyte_glucose1.21141487
79MP0002148_abnormal_hypersensitivity_rea1.19211824
80MP0002933_joint_inflammation1.19146584
81MP0009785_altered_susceptibility_to1.18970896
82MP0009333_abnormal_splenocyte_physiolog1.18858101
83MP0003191_abnormal_cellular_cholesterol1.18700908
84MP0001486_abnormal_startle_reflex1.18207358
85MP0000372_irregular_coat_pigmentation1.17364782
86MP0000751_myopathy1.16236374
87* MP0000703_abnormal_thymus_morphology1.15369273
88MP0003634_abnormal_glial_cell1.14472182
89MP0002837_dystrophic_cardiac_calcinosis1.14457565
90* MP0000716_abnormal_immune_system1.13746405
91MP0001845_abnormal_inflammatory_respons1.12736955
92MP0004270_analgesia1.11707260
93MP0003633_abnormal_nervous_system1.09357669
94MP0002909_abnormal_adrenal_gland1.08698595
95MP0009745_abnormal_behavioral_response1.08509449
96MP0001545_abnormal_hematopoietic_system1.07263098
97MP0005397_hematopoietic_system_phenotyp1.07263098
98MP0005666_abnormal_adipose_tissue1.06871108
99MP0005166_decreased_susceptibility_to1.06697059
100MP0000750_abnormal_muscle_regeneration1.06172374
101MP0003448_altered_tumor_morphology1.05674542
102MP0006082_CNS_inflammation1.05338262
103MP0000767_abnormal_smooth_muscle1.04266975
104MP0005375_adipose_tissue_phenotype1.03863398
105MP0003880_abnormal_central_pattern0.99310094
106MP0002396_abnormal_hematopoietic_system0.98807834
107* MP0003866_abnormal_defecation0.98557729
108MP0000249_abnormal_blood_vessel0.98513198
109MP0000465_gastrointestinal_hemorrhage0.98124332
110MP0001502_abnormal_circadian_rhythm0.96177363
111MP0008874_decreased_physiological_sensi0.95444357
112MP0005310_abnormal_salivary_gland0.95130397
113MP0004087_abnormal_muscle_fiber0.95056013
114MP0002722_abnormal_immune_system0.94305425
115MP0000343_altered_response_to0.94012526
116MP0004484_altered_response_of0.93713642
117MP0001544_abnormal_cardiovascular_syste0.93346829
118MP0005385_cardiovascular_system_phenoty0.93346829
119MP0001986_abnormal_taste_sensitivity0.92299385
120MP0003631_nervous_system_phenotype0.92078065
121MP0000689_abnormal_spleen_morphology0.92050449
122MP0004272_abnormal_basement_membrane0.91638975
123MP0005174_abnormal_tail_pigmentation0.91124390
124MP0000371_diluted_coat_color0.91033483
125MP0000003_abnormal_adipose_tissue0.90787023
126MP0002972_abnormal_cardiac_muscle0.89957632
127MP0005275_abnormal_skin_tensile0.89902327
128MP0002168_other_aberrant_phenotype0.89608939
129MP0002009_preneoplasia0.89280213
130MP0004215_abnormal_myocardial_fiber0.89049579
131MP0002572_abnormal_emotion/affect_behav0.88610180
132MP0002272_abnormal_nervous_system0.88458658
133MP0003879_abnormal_hair_cell0.88054181
134MP0000013_abnormal_adipose_tissue0.87601441
135MP0002138_abnormal_hepatobiliary_system0.87372513
136MP0002928_abnormal_bile_duct0.86875895
137MP0003632_abnormal_nervous_system0.84432425
138MP0004858_abnormal_nervous_system0.83780256
139* MP0002429_abnormal_blood_cell0.83466135
140MP0008775_abnormal_heart_ventricle0.81935675
141MP0001348_abnormal_lacrimal_gland0.76446278
142MP0002133_abnormal_respiratory_system0.74004517
143MP0005388_respiratory_system_phenotype0.74004517

Predicted human phenotypes

RankGene SetZ-score
1Stomatitis (HP:0010280)3.77303801
2Obstructive sleep apnea (HP:0002870)3.64470764
3Cerebral aneurysm (HP:0004944)3.63628551
4Abnormality of binocular vision (HP:0011514)3.61315282
5Diplopia (HP:0000651)3.61315282
6Hematochezia (HP:0002573)3.60687801
7Peripheral hypomyelination (HP:0007182)3.48803532
8Ocular albinism (HP:0001107)3.38689684
9Supranuclear gaze palsy (HP:0000605)3.35046578
10Hemiplegia (HP:0002301)3.26032405
11Neurofibrillary tangles (HP:0002185)3.16208195
12Elevated erythrocyte sedimentation rate (HP:0003565)3.10977479
13Abnormality of the fingertips (HP:0001211)3.08688128
14Eczematoid dermatitis (HP:0000976)2.97822488
15Slow saccadic eye movements (HP:0000514)2.89792314
16Abnormality of the nasal mucosa (HP:0000433)2.86138786
17Iris hypopigmentation (HP:0007730)2.84798009
18Spontaneous hematomas (HP:0007420)2.82505210
19Hyporeflexia of lower limbs (HP:0002600)2.76852306
20Aortic aneurysm (HP:0004942)2.74224473
21T lymphocytopenia (HP:0005403)2.72638317
22Abnormality of T cell number (HP:0011839)2.71263681
23Meningitis (HP:0001287)2.71183247
24Ankle clonus (HP:0011448)2.67783579
25Cerebral inclusion bodies (HP:0100314)2.66040911
26Autoimmune thrombocytopenia (HP:0001973)2.58239130
27Abnormality of macrophages (HP:0004311)2.57665662
28Colitis (HP:0002583)2.56710016
29Recurrent viral infections (HP:0004429)2.55481312
30Abnormal delayed hypersensitivity skin test (HP:0002963)2.51912503
31Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.49247625
32Recurrent fungal infections (HP:0002841)2.47034960
33Recurrent abscess formation (HP:0002722)2.46967221
34Asymmetric septal hypertrophy (HP:0001670)2.45738948
35Ventricular tachycardia (HP:0004756)2.43470369
36Increased connective tissue (HP:0009025)2.43431238
37Action tremor (HP:0002345)2.43382206
38Annular pancreas (HP:0001734)2.41761173
39Gastrointestinal stroma tumor (HP:0100723)2.40462084
40Segmental peripheral demyelination/remyelination (HP:0003481)2.36337986
41Agammaglobulinemia (HP:0004432)2.36271386
42Increased CSF protein (HP:0002922)2.35493073
43Sudden death (HP:0001699)2.34687844
44Neuronal loss in central nervous system (HP:0002529)2.33454748
45Inflammation of the large intestine (HP:0002037)2.31289431
46Aneurysm (HP:0002617)2.30869396
47Nasal polyposis (HP:0100582)2.30424897
48Autoimmune hemolytic anemia (HP:0001890)2.30418491
49Gastrointestinal infarctions (HP:0005244)2.29212419
50Frequent falls (HP:0002359)2.26929159
51Increased cerebral lipofuscin (HP:0011813)2.26901740
52Blue irides (HP:0000635)2.24006911
53Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.23167919
54Dysostosis multiplex (HP:0000943)2.22933109
55Urinary glycosaminoglycan excretion (HP:0003541)2.20994991
56Mucopolysacchariduria (HP:0008155)2.20994991
57Gastrointestinal inflammation (HP:0004386)2.19584013
58Broad metatarsal (HP:0001783)2.18921017
59Abnormality of polysaccharide metabolism (HP:0011012)2.18464185
60Abnormality of glycosaminoglycan metabolism (HP:0004371)2.18464185
61Abnormality of mucopolysaccharide metabolism (HP:0011020)2.18464185
62Chronic obstructive pulmonary disease (HP:0006510)2.16341032
63Obstructive lung disease (HP:0006536)2.16341032
64Myositis (HP:0100614)2.16046723
65Facial diplegia (HP:0001349)2.15233610
66Polycythemia (HP:0001901)2.14944959
67Truncal ataxia (HP:0002078)2.14428468
68Recurrent skin infections (HP:0001581)2.13960988
69Long toe (HP:0010511)2.13363398
70Abnormality of the left ventricular outflow tract (HP:0011103)2.13340164
71Subaortic stenosis (HP:0001682)2.13340164
72Onion bulb formation (HP:0003383)2.10626529
73Panhypogammaglobulinemia (HP:0003139)2.09780153
74Recurrent bacterial skin infections (HP:0005406)2.07999145
75Keratoconjunctivitis sicca (HP:0001097)2.07319926
76Chest pain (HP:0100749)2.07167998
77Recurrent gram-negative bacterial infections (HP:0005420)2.05536895
78Prolonged bleeding time (HP:0003010)2.02348351
79Pulmonary embolism (HP:0002204)2.02008534
80Eosinophilia (HP:0001880)2.01579751
81Mitral valve prolapse (HP:0001634)2.01536465
82Encephalitis (HP:0002383)1.98912285
83Scanning speech (HP:0002168)1.97752862
84Abnormality of the periventricular white matter (HP:0002518)1.97704116
85Postural instability (HP:0002172)1.97680801
86Arterial thrombosis (HP:0004420)1.97522930
87Visual hallucinations (HP:0002367)1.97278603
88Papilloma (HP:0012740)1.96907226
89Verrucae (HP:0200043)1.96907226
90Hypoplasia of the iris (HP:0007676)1.96368400
91Recurrent bronchitis (HP:0002837)1.96265137
92Bundle branch block (HP:0011710)1.95965731
93Increased IgE level (HP:0003212)1.95305600
94Orchitis (HP:0100796)1.95137821
95Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.94687081
96Spinal canal stenosis (HP:0003416)1.94100471
97Focal motor seizures (HP:0011153)1.93649206
98Vertebral arch anomaly (HP:0008438)1.91644689
99Macroorchidism (HP:0000053)1.91622548
100Gingivitis (HP:0000230)1.90763369
101Insulin-resistant diabetes mellitus (HP:0000831)1.90372721
102Difficulty running (HP:0009046)1.90040082
103Bicuspid aortic valve (HP:0001647)1.89566247
104Keratoconjunctivitis (HP:0001096)1.89033710
105Amyloidosis (HP:0011034)1.87890644
106Large for gestational age (HP:0001520)1.87656237
107Striae distensae (HP:0001065)1.85775826
108Spastic gait (HP:0002064)1.85614371
109Lymphopenia (HP:0001888)1.85182869
110Global brain atrophy (HP:0002283)1.85078474
111Vasculitis (HP:0002633)1.84063397
112Abnormality of T cells (HP:0002843)1.83848743
113Disproportionate tall stature (HP:0001519)1.83668781
114Pulmonary infiltrates (HP:0002113)1.83498949
115Rapidly progressive (HP:0003678)1.83457033
116Interstitial pulmonary disease (HP:0006530)1.83415351
117Aortic dissection (HP:0002647)1.82722153
118Abnormality of liposaccharide metabolism (HP:0010968)1.82652188
119Abnormality of glycosphingolipid metabolism (HP:0004343)1.82652188
120Abnormality of glycolipid metabolism (HP:0010969)1.82652188
121Leukocytosis (HP:0001974)1.82257367
122Hyperinsulinemic hypoglycemia (HP:0000825)1.81417356
123Loss of speech (HP:0002371)1.81317167
124Chronic otitis media (HP:0000389)1.80828402
125Narrow palate (HP:0000189)1.80204387
126Emphysema (HP:0002097)1.80180936
127Myocardial infarction (HP:0001658)1.77723107
128Tetraparesis (HP:0002273)1.77396109
129Persistence of primary teeth (HP:0006335)1.77129034
130Right ventricular cardiomyopathy (HP:0011663)1.76830369
131Periodontitis (HP:0000704)1.76420725
132Arterial tortuosity (HP:0005116)1.75849364
133Mediastinal lymphadenopathy (HP:0100721)1.75321159
134Muscle fiber splitting (HP:0003555)1.74727808
135Decreased motor nerve conduction velocity (HP:0003431)1.74499486
136Osteomyelitis (HP:0002754)1.73996332
137Hyperacusis (HP:0010780)1.72922104
138Pustule (HP:0200039)1.72894084
139Urethral obstruction (HP:0000796)1.72588969
140Viral hepatitis (HP:0006562)1.72460486
141Sepsis (HP:0100806)1.72145934
142Papilledema (HP:0001085)1.71717510
143Atrioventricular block (HP:0001678)1.71646298
144Thick nail (HP:0001805)1.71580935
145Stereotypic behavior (HP:0000733)1.71132607
146Restrictive lung disease (HP:0002091)1.70528362
147Cellulitis (HP:0100658)1.70178106
148Thin bony cortex (HP:0002753)1.69093701
149Dilatation of the ascending aorta (HP:0005111)1.67161520
150Increased density of long bones (HP:0006392)1.66395629
151Increased neuronal autofluorescent lipopigment (HP:0002074)1.65857574
152Hemoptysis (HP:0002105)1.65567176
153Rectal prolapse (HP:0002035)1.65175390
154Spondylolisthesis (HP:0003302)1.63725469
155Atrial fibrillation (HP:0005110)1.62856823
156Retrobulbar optic neuritis (HP:0100654)1.62160428
157Optic neuritis (HP:0100653)1.62160428
158Recurrent cutaneous fungal infections (HP:0011370)1.61923397
159Chronic mucocutaneous candidiasis (HP:0002728)1.61923397

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PRPF4B3.76105037
2MAP4K13.13436708
3TRIB32.64172629
4TXK2.33931911
5RIPK12.28825110
6TGFBR22.28283065
7TTN2.27798677
8BLK2.11469761
9ERN12.05599702
10TIE12.04051512
11ITK1.99231462
12JAK11.89311485
13NTRK21.89174917
14TNK21.88546926
15JAK31.83582726
16CAMKK11.83041727
17TYK21.82748619
18MAP3K101.80302752
19ZAP701.76724281
20PTK61.75521527
21CDK121.73767175
22EEF2K1.71569540
23FGFR31.70282472
24MAP3K141.69557901
25DMPK1.64884199
26FGFR41.64089695
27INSRR1.64072571
28PKN21.61907051
29TAOK31.58010903
30PRKCH1.55055738
31UHMK11.55001822
32EPHB11.54523924
33IRAK31.54394290
34TYRO31.54162163
35CAMK1G1.49754242
36CAMK1D1.49376011
37TBK11.46546979
38SIK11.41846812
39IKBKE1.40131339
40PAK61.39500035
41NTRK31.31915847
42MAP2K31.31861872
43KDR1.28128297
44PDGFRA1.25799004
45KSR21.24822538
46HIPK21.24529011
47STK101.19533917
48HCK1.17460134
49BRD41.17273165
50EPHA31.16885250
51CSK1.13383064
52PDGFRB1.10923920
53MAP3K111.10701224
54JAK21.07803294
55NLK1.06897854
56MARK31.06876202
57SIK31.05025773
58CHUK1.03879753
59MAP3K11.03670973
60MAP3K31.03015127
61SGK4940.99730080
62SGK2230.99730080
63LCK0.96594425
64SIK20.93858742
65BTK0.92855982
66MAP3K70.92478746
67TEC0.90192554
68SGK30.86608580
69IKBKB0.86005026
70LMTK20.82916596
71SMG10.82627909
72DAPK20.82181646
73MAP3K20.82141642
74PRKD10.81711970
75STK380.81450425
76MAP3K130.80090642
77RET0.79619685
78LYN0.77986295
79NEK60.77405892
80LRRK20.77216730
81KIT0.76366801
82PDPK10.76043506
83FES0.75088818
84PRKD20.72118614
85FYN0.70531281
86SYK0.70478794
87MARK20.69826894
88MAPK120.66442150
89MAPK70.65992407
90RIPK40.65537618
91STK110.65500480
92BMPR20.63981795
93FGR0.63010096
94WNK10.62758839
95ICK0.62731096
96TAOK10.61912331
97MAPKAPK30.61797571
98CDK60.61744143
99MAPK150.61740654
100GRK50.60880497
101TRPM70.60603616
102CDK90.58201549
103RPS6KA40.57631911
104MTOR0.57283287
105MAPK40.57109294
106PTK20.56923254
107CDC42BPA0.54434057
108MAPK100.54304272
109CAMK10.53043030
110CDK50.52540239
111PRKAA20.51913463
112SGK20.50906178
113ROCK20.50402945
114CSF1R0.50380606
115IRAK40.50207287
116IGF1R0.49834882
117TAOK20.48777711
118PRKCQ0.48500836
119SGK10.48040981
120IRAK20.47991252
121ARAF0.47545172
122EGFR0.47373069
123GSK3A0.47306613
124FLT30.47265846
125CAMKK20.46713585
126GRK60.46149075
127PASK0.45922546
128PDK10.45558531
129RPS6KA20.45321838
130CAMK40.44734032
131FER0.42306678
132ALK0.42062382
133NEK90.40806769
134FGFR20.40710714
135TGFBR10.39768076
136PRKD30.38629769

Predicted pathways (KEGG)

RankGene SetZ-score
1Osteoclast differentiation_Homo sapiens_hsa043802.07012816
2Primary immunodeficiency_Homo sapiens_hsa053401.93129626
3T cell receptor signaling pathway_Homo sapiens_hsa046601.82520927
4Type II diabetes mellitus_Homo sapiens_hsa049301.80927762
5Long-term potentiation_Homo sapiens_hsa047201.67472452
6NF-kappa B signaling pathway_Homo sapiens_hsa040641.67222934
7B cell receptor signaling pathway_Homo sapiens_hsa046621.66434850
8Leishmaniasis_Homo sapiens_hsa051401.65590048
9Toxoplasmosis_Homo sapiens_hsa051451.55980774
10Measles_Homo sapiens_hsa051621.48268006
11Insulin resistance_Homo sapiens_hsa049311.47882931
12Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.46322460
13AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.40155677
14Toll-like receptor signaling pathway_Homo sapiens_hsa046201.37845224
15Chronic myeloid leukemia_Homo sapiens_hsa052201.37718958
16Dorso-ventral axis formation_Homo sapiens_hsa043201.37587222
17Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.35977312
18TNF signaling pathway_Homo sapiens_hsa046681.30804361
19Leukocyte transendothelial migration_Homo sapiens_hsa046701.29479264
20Viral myocarditis_Homo sapiens_hsa054161.28810156
21Carbohydrate digestion and absorption_Homo sapiens_hsa049731.24584151
22Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.24469611
23Autoimmune thyroid disease_Homo sapiens_hsa053201.23877559
24GnRH signaling pathway_Homo sapiens_hsa049121.23520021
25Dilated cardiomyopathy_Homo sapiens_hsa054141.23294573
26Acute myeloid leukemia_Homo sapiens_hsa052211.23161108
27Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.22996314
28Gastric acid secretion_Homo sapiens_hsa049711.21586558
29Hematopoietic cell lineage_Homo sapiens_hsa046401.19887256
30Jak-STAT signaling pathway_Homo sapiens_hsa046301.19072160
31NOD-like receptor signaling pathway_Homo sapiens_hsa046211.18327971
32Prolactin signaling pathway_Homo sapiens_hsa049171.16755764
33Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.16021238
34Platelet activation_Homo sapiens_hsa046111.14473781
35Circadian entrainment_Homo sapiens_hsa047131.14439365
36Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.14329058
37Adipocytokine signaling pathway_Homo sapiens_hsa049201.13690428
38Morphine addiction_Homo sapiens_hsa050321.10945877
39Focal adhesion_Homo sapiens_hsa045101.08253547
40Chemokine signaling pathway_Homo sapiens_hsa040621.08083238
41Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.06664178
42Influenza A_Homo sapiens_hsa051641.06000782
43Neurotrophin signaling pathway_Homo sapiens_hsa047221.05853515
44Intestinal immune network for IgA production_Homo sapiens_hsa046721.05671913
45Maturity onset diabetes of the young_Homo sapiens_hsa049501.05486189
46Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.04547312
47Glycosaminoglycan degradation_Homo sapiens_hsa005311.03490997
48Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.03489146
49Small cell lung cancer_Homo sapiens_hsa052221.03466487
50Antigen processing and presentation_Homo sapiens_hsa046121.03421542
51Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.03073058
52Cholinergic synapse_Homo sapiens_hsa047251.01994305
53Malaria_Homo sapiens_hsa051441.00915261
54Synaptic vesicle cycle_Homo sapiens_hsa047211.00721179
55Thyroid hormone signaling pathway_Homo sapiens_hsa049190.99170969
56VEGF signaling pathway_Homo sapiens_hsa043700.99143773
57Pancreatic cancer_Homo sapiens_hsa052120.98726507
58Glutamatergic synapse_Homo sapiens_hsa047240.97999885
59Choline metabolism in cancer_Homo sapiens_hsa052310.97922436
60Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.97866519
61Pertussis_Homo sapiens_hsa051330.97802491
62Tuberculosis_Homo sapiens_hsa051520.96517224
63ErbB signaling pathway_Homo sapiens_hsa040120.96369362
64Amoebiasis_Homo sapiens_hsa051460.95359997
65Proteoglycans in cancer_Homo sapiens_hsa052050.94125007
66Adherens junction_Homo sapiens_hsa045200.94056428
67Lysosome_Homo sapiens_hsa041420.93512211
68RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.92467810
69Hepatitis B_Homo sapiens_hsa051610.92423841
70Staphylococcus aureus infection_Homo sapiens_hsa051500.92385064
71Lysine degradation_Homo sapiens_hsa003100.91940121
72Notch signaling pathway_Homo sapiens_hsa043300.91792935
73Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.91789266
74Oxytocin signaling pathway_Homo sapiens_hsa049210.91646684
75Graft-versus-host disease_Homo sapiens_hsa053320.91347137
76Amphetamine addiction_Homo sapiens_hsa050310.90834690
77Other glycan degradation_Homo sapiens_hsa005110.89323680
78mTOR signaling pathway_Homo sapiens_hsa041500.89148952
79Type I diabetes mellitus_Homo sapiens_hsa049400.88424580
80* Inositol phosphate metabolism_Homo sapiens_hsa005620.86470007
81ECM-receptor interaction_Homo sapiens_hsa045120.86339118
82Colorectal cancer_Homo sapiens_hsa052100.85981543
83Apoptosis_Homo sapiens_hsa042100.85887802
84* Phosphatidylinositol signaling system_Homo sapiens_hsa040700.85644927
85cGMP-PKG signaling pathway_Homo sapiens_hsa040220.85580972
86Renal cell carcinoma_Homo sapiens_hsa052110.85038576
87Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.83585733
88Allograft rejection_Homo sapiens_hsa053300.83393393
89GABAergic synapse_Homo sapiens_hsa047270.83279722
90Insulin secretion_Homo sapiens_hsa049110.83064706
91Aldosterone synthesis and secretion_Homo sapiens_hsa049250.82615994
92Hepatitis C_Homo sapiens_hsa051600.80646029
93Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.80386841
94Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.79922266
95Salivary secretion_Homo sapiens_hsa049700.78848129
96FoxO signaling pathway_Homo sapiens_hsa040680.76715293
97Renin secretion_Homo sapiens_hsa049240.76351178
98Melanogenesis_Homo sapiens_hsa049160.75280617
99Prion diseases_Homo sapiens_hsa050200.74993419
100Insulin signaling pathway_Homo sapiens_hsa049100.73939218
101Ras signaling pathway_Homo sapiens_hsa040140.73625242
102Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.73352951
103Endometrial cancer_Homo sapiens_hsa052130.73215485
104Estrogen signaling pathway_Homo sapiens_hsa049150.72408610
105HTLV-I infection_Homo sapiens_hsa051660.72212481
106Regulation of actin cytoskeleton_Homo sapiens_hsa048100.72106751
107Prostate cancer_Homo sapiens_hsa052150.71770795
108Longevity regulating pathway - mammal_Homo sapiens_hsa042110.71308045
109Non-small cell lung cancer_Homo sapiens_hsa052230.70103524
110Legionellosis_Homo sapiens_hsa051340.69937948
111Salmonella infection_Homo sapiens_hsa051320.69521092
112MAPK signaling pathway_Homo sapiens_hsa040100.69384564
113Herpes simplex infection_Homo sapiens_hsa051680.68362241
114Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.67663717
115Endocytosis_Homo sapiens_hsa041440.67480405
116Phospholipase D signaling pathway_Homo sapiens_hsa040720.65717395
117Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.65716257
118Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.65181688
119Sphingolipid signaling pathway_Homo sapiens_hsa040710.64903406
120Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.64499697
121Rap1 signaling pathway_Homo sapiens_hsa040150.64349838
122Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.63364046
123Pancreatic secretion_Homo sapiens_hsa049720.63276356
124Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.62742328
125Glioma_Homo sapiens_hsa052140.60676427
126cAMP signaling pathway_Homo sapiens_hsa040240.60544788
127Vascular smooth muscle contraction_Homo sapiens_hsa042700.60343427
128Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.59686957

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