ITPR1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes an intracellular receptor for inositol 1,4,5-trisphosphate. Upon stimulation by inositol 1,4,5-trisphosphate, this receptor mediates calcium release from the endoplasmic reticulum. Mutations in this gene cause spinocerebellar ataxia type 15, a disease associated with an heterogeneous group of cerebellar disorders. Multiple transcript variants have been identified for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1locomotory exploration behavior (GO:0035641)6.53370193
2neuronal action potential propagation (GO:0019227)6.07365165
3cerebellar granule cell differentiation (GO:0021707)6.06927101
4positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.80835084
5synaptic vesicle maturation (GO:0016188)5.68664216
6positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.66217723
7regulation of short-term neuronal synaptic plasticity (GO:0048172)5.55977430
8ionotropic glutamate receptor signaling pathway (GO:0035235)5.47693675
9gamma-aminobutyric acid transport (GO:0015812)5.38456918
10cerebellar Purkinje cell differentiation (GO:0021702)5.29865903
11short-term memory (GO:0007614)5.26438277
12cellular potassium ion homeostasis (GO:0030007)5.26428782
13vocalization behavior (GO:0071625)5.15044874
14glutamate receptor signaling pathway (GO:0007215)5.12579797
15sodium ion export (GO:0071436)5.10004117
16G-protein coupled glutamate receptor signaling pathway (GO:0007216)5.05190442
17response to pheromone (GO:0019236)4.98563393
18synaptic transmission, glutamatergic (GO:0035249)4.97114962
19regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.86541585
20neurotransmitter secretion (GO:0007269)4.79755224
21synaptic vesicle exocytosis (GO:0016079)4.75046167
22regulation of synaptic vesicle exocytosis (GO:2000300)4.68419217
23long-term memory (GO:0007616)4.68414484
24membrane depolarization during cardiac muscle cell action potential (GO:0086012)4.63766034
25neuron-neuron synaptic transmission (GO:0007270)4.54184313
26cerebellar Purkinje cell layer development (GO:0021680)4.47289003
27glutamate secretion (GO:0014047)4.46652930
28cell differentiation in hindbrain (GO:0021533)4.44655892
29synaptic vesicle docking involved in exocytosis (GO:0016081)4.44341794
30positive regulation of phosphoprotein phosphatase activity (GO:0032516)4.41978451
31positive regulation of synapse maturation (GO:0090129)4.35778359
32regulation of synapse structural plasticity (GO:0051823)4.28632042
33exploration behavior (GO:0035640)4.26249671
34regulation of glutamate receptor signaling pathway (GO:1900449)4.25355772
35neuromuscular process controlling balance (GO:0050885)4.24919507
36regulation of long-term neuronal synaptic plasticity (GO:0048169)4.24128912
37neuromuscular process controlling posture (GO:0050884)4.13315881
38regulation of excitatory postsynaptic membrane potential (GO:0060079)4.11967755
39regulation of synaptic vesicle transport (GO:1902803)4.11344616
40cell communication by electrical coupling involved in cardiac conduction (GO:0086064)4.10008337
41gamma-aminobutyric acid signaling pathway (GO:0007214)4.08396365
42prepulse inhibition (GO:0060134)4.07593393
43neurotransmitter-gated ion channel clustering (GO:0072578)4.02064819
44regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)4.00313474
45layer formation in cerebral cortex (GO:0021819)3.93826859
46metanephric nephron tubule development (GO:0072234)3.90508981
47metanephric tubule development (GO:0072170)3.90508981
48regulation of neuronal synaptic plasticity (GO:0048168)3.88790125
49positive regulation of muscle hypertrophy (GO:0014742)3.87221972
50positive regulation of cardiac muscle hypertrophy (GO:0010613)3.87221972
51positive regulation of membrane potential (GO:0045838)3.84644786
52potassium ion import (GO:0010107)3.83548695
53regulation of postsynaptic membrane potential (GO:0060078)3.80747988
54transmission of nerve impulse (GO:0019226)3.76200868
55negative regulation of dendrite morphogenesis (GO:0050774)3.74310413
56response to histamine (GO:0034776)3.72689656
57neurotransmitter transport (GO:0006836)3.70695640
58positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.70606222
59membrane depolarization during action potential (GO:0086010)3.67976443
60cell communication by electrical coupling (GO:0010644)3.62664536
61auditory behavior (GO:0031223)3.62239634
62activation of protein kinase A activity (GO:0034199)3.59794487
63C4-dicarboxylate transport (GO:0015740)3.59723652
64glycine transport (GO:0015816)3.58910071
65metanephric nephron epithelium development (GO:0072243)3.57807371
66long term synaptic depression (GO:0060292)3.57755926
67regulation of neurotransmitter levels (GO:0001505)3.56568194
68regulation of voltage-gated calcium channel activity (GO:1901385)3.54833472
69dendritic spine morphogenesis (GO:0060997)3.52953316
70protein localization to synapse (GO:0035418)3.52818375
71relaxation of cardiac muscle (GO:0055119)3.50983296
72regulation of ARF protein signal transduction (GO:0032012)3.50941520
73cellular sodium ion homeostasis (GO:0006883)3.49054211
74adult walking behavior (GO:0007628)3.47665107
75regulation of dendritic spine morphogenesis (GO:0061001)3.47225463
76membrane depolarization (GO:0051899)3.46985386
77regulation of synaptic transmission, glutamatergic (GO:0051966)3.42011866
78serotonin metabolic process (GO:0042428)3.38704387
79negative regulation of hormone metabolic process (GO:0032351)3.36208941
80negative regulation of hormone biosynthetic process (GO:0032353)3.36208941
81regulation of neurotransmitter secretion (GO:0046928)3.35363464
82regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)3.35130722
83establishment of nucleus localization (GO:0040023)3.34398585
84negative regulation of synaptic transmission, GABAergic (GO:0032229)3.31748275
85relaxation of smooth muscle (GO:0044557)3.31031654
86regulation of synaptic plasticity (GO:0048167)3.30482615
87regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.30334526
88synaptic vesicle endocytosis (GO:0048488)3.29857898
89membrane hyperpolarization (GO:0060081)3.29571461
90mechanosensory behavior (GO:0007638)3.28998522
91potassium ion homeostasis (GO:0055075)3.28857117
92positive regulation of synaptic transmission, GABAergic (GO:0032230)3.28775691
93dendrite morphogenesis (GO:0048813)3.27533140
94positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)3.26802983
95neuromuscular process (GO:0050905)3.24888160
96metanephric epithelium development (GO:0072207)3.24766927
97positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.24174700
98regulation of synapse maturation (GO:0090128)3.24048760
99positive regulation of calcium ion transmembrane transporter activity (GO:1901021)3.23972506
100detection of calcium ion (GO:0005513)3.19986461
101regulation of neurotransmitter transport (GO:0051588)3.17370038
102long-term synaptic potentiation (GO:0060291)3.17175357
103negative regulation of amyloid precursor protein catabolic process (GO:1902992)3.16905512
104peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)3.15515296
105amino acid import (GO:0043090)3.14632538
106positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.12579089
107neurofilament cytoskeleton organization (GO:0060052)3.11665976
108fructose metabolic process (GO:0006000)3.09335361
109chemosensory behavior (GO:0007635)3.08063121
110positive regulation of dendritic spine morphogenesis (GO:0061003)3.07047774
111collecting duct development (GO:0072044)3.06760552
112neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)3.04507061
113acidic amino acid transport (GO:0015800)3.02381799
114response to auditory stimulus (GO:0010996)3.02211500
115proline transport (GO:0015824)2.98602595
116positive regulation of nitric-oxide synthase activity (GO:0051000)2.98581579
117mating behavior (GO:0007617)2.98311515
118positive regulation of potassium ion transmembrane transport (GO:1901381)2.97812147
119L-amino acid import (GO:0043092)2.97335894
120positive regulation of dendritic spine development (GO:0060999)2.96770645
121relaxation of muscle (GO:0090075)2.94779956
122negative regulation of heart contraction (GO:0045822)2.94633735
123regulation of vesicle fusion (GO:0031338)2.93742211
124regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.93565377
125synapse assembly (GO:0007416)2.93491388
126regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.91853050
127regulation of calcium ion-dependent exocytosis (GO:0017158)2.90537114
128synaptic transmission (GO:0007268)2.89853800
129cytoskeletal anchoring at plasma membrane (GO:0007016)2.87355999
130neuron cell-cell adhesion (GO:0007158)2.85818263
131primary amino compound metabolic process (GO:1901160)2.84145640
132negative regulation of fatty acid transport (GO:2000192)2.80036694
133cellular response to ammonium ion (GO:0071242)2.79162193
134cGMP metabolic process (GO:0046068)2.77843565
135glucocorticoid receptor signaling pathway (GO:0042921)2.76109166
136regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO2.74348173
137retina layer formation (GO:0010842)2.72199422
138regulation of synaptic transmission (GO:0050804)2.71060098
139sodium ion homeostasis (GO:0055078)2.70088772
140endocrine hormone secretion (GO:0060986)2.69689695

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.66600374
2SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.26492512
3DROSHA_22980978_ChIP-Seq_HELA_Human3.15259928
4SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.95551555
5IKZF1_21737484_ChIP-ChIP_HCT116_Human2.86331225
6JARID2_20064375_ChIP-Seq_MESCs_Mouse2.86127870
7EZH2_18974828_ChIP-Seq_MESCs_Mouse2.84651122
8RNF2_18974828_ChIP-Seq_MESCs_Mouse2.84651122
9RARB_27405468_Chip-Seq_BRAIN_Mouse2.79073175
10MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.75202211
11REST_21632747_ChIP-Seq_MESCs_Mouse2.65484119
12MTF2_20144788_ChIP-Seq_MESCs_Mouse2.60276848
13GBX2_23144817_ChIP-Seq_PC3_Human2.59791653
14EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.58154266
15JARID2_20075857_ChIP-Seq_MESCs_Mouse2.54496471
16SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.48685242
17SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.45633191
18SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.42892700
19SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.34715292
20EZH2_27294783_Chip-Seq_ESCs_Mouse2.27828913
21TAF15_26573619_Chip-Seq_HEK293_Human2.22685046
22REST_18959480_ChIP-ChIP_MESCs_Mouse2.19643453
23BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.19485586
24RNF2_27304074_Chip-Seq_ESCs_Mouse2.14064080
25SUZ12_27294783_Chip-Seq_ESCs_Mouse2.11087838
26EED_16625203_ChIP-ChIP_MESCs_Mouse2.06633868
27EZH2_27304074_Chip-Seq_ESCs_Mouse2.05868705
28ERG_21242973_ChIP-ChIP_JURKAT_Human1.88580352
29ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.85340729
30GATA1_22025678_ChIP-Seq_K562_Human1.81957228
31* STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.81765275
32* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.61818672
33GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.61605844
34FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.56677513
35* KDM2B_26808549_Chip-Seq_K562_Human1.52906518
36AR_21572438_ChIP-Seq_LNCaP_Human1.49947170
37FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.48292256
38CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.47370607
39THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.46636981
40DNAJC2_21179169_ChIP-ChIP_NT2_Human1.44809033
41RUNX_20019798_ChIP-Seq_JUKART_Human1.44278508
42* SMAD4_21799915_ChIP-Seq_A2780_Human1.44159714
43ZNF274_21170338_ChIP-Seq_K562_Hela1.41262043
44AR_19668381_ChIP-Seq_PC3_Human1.38881420
45RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.37151714
46TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.34839013
47EGR1_19374776_ChIP-ChIP_THP-1_Human1.32435089
48* GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.31196053
49PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.30588924
50SCL_19346495_ChIP-Seq_HPC-7_Human1.30041383
51IRF8_22096565_ChIP-ChIP_GC-B_Human1.29871813
52Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.27408401
53* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.25979511
54* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.25444583
55RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.23388111
56* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.23302993
57TP53_16413492_ChIP-PET_HCT116_Human1.22613734
58SOX2_21211035_ChIP-Seq_LN229_Gbm1.19343332
59RING1B_27294783_Chip-Seq_ESCs_Mouse1.19260697
60CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.18442242
61CTBP2_25329375_ChIP-Seq_LNCAP_Human1.18315794
62* STAT3_23295773_ChIP-Seq_U87_Human1.17649735
63SMAD_19615063_ChIP-ChIP_OVARY_Human1.17342840
64SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.15667822
65GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.15472558
66NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.15391497
67* PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.15284927
68SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.12686131
69ZFP281_27345836_Chip-Seq_ESCs_Mouse1.10888460
70NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.09949301
71* ZNF217_24962896_ChIP-Seq_MCF-7_Human1.09811008
72ZFP281_18757296_ChIP-ChIP_E14_Mouse1.09491230
73RING1B_27294783_Chip-Seq_NPCs_Mouse1.08619129
74RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.07490740
75PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.06699507
76POU3F2_20337985_ChIP-ChIP_501MEL_Human1.06636792
77NR3C1_23031785_ChIP-Seq_PC12_Mouse1.06596985
78TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.04627137
79SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.04500188
80AR_25329375_ChIP-Seq_VCAP_Human1.04458650
81GATA2_21666600_ChIP-Seq_HMVEC_Human1.03486876
82KDM2B_26808549_Chip-Seq_SUP-B15_Human1.03405878
83* CTNNB1_20460455_ChIP-Seq_HCT116_Human1.02885731
84DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.02766690
85* TCF4_23295773_ChIP-Seq_U87_Human1.02685849
86* GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.01160215
87TET1_21490601_ChIP-Seq_MESCs_Mouse1.00654063
88RXR_22108803_ChIP-Seq_LS180_Human1.00025524
89* SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.99666965
90* TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.99090058
91ZFP57_27257070_Chip-Seq_ESCs_Mouse0.99005564
92SMAD3_21741376_ChIP-Seq_HESCs_Human0.98783436
93ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.98710259
94FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse0.98627891
95YAP1_20516196_ChIP-Seq_MESCs_Mouse0.98346081
96SMAD4_21741376_ChIP-Seq_HESCs_Human0.98187261
97MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.97743757
98* NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.97696468
99CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.97085095
100CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.96759778
101* NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.96200029
102CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.95707146
103SPI1_23127762_ChIP-Seq_K562_Human0.94786858
104SMAD3_21741376_ChIP-Seq_ESCs_Human0.94651160
105CDX2_19796622_ChIP-Seq_MESCs_Mouse0.94495464
106* TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.94128526
107CTBP1_25329375_ChIP-Seq_LNCAP_Human0.94103982
108ARNT_22903824_ChIP-Seq_MCF-7_Human0.93913033
109STAT3_20064451_ChIP-Seq_CD4+T_Mouse0.93853468
110RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.92707502
111PIAS1_25552417_ChIP-Seq_VCAP_Human0.91362079
112SMAD3_21741376_ChIP-Seq_EPCs_Human0.90852825
113P53_22127205_ChIP-Seq_FIBROBLAST_Human0.90808822
114VDR_22108803_ChIP-Seq_LS180_Human0.90580839
115* ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.90492551
116SRY_22984422_ChIP-ChIP_TESTIS_Rat0.90352530
117SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse0.90016120
118* PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.89952691
119AHR_22903824_ChIP-Seq_MCF-7_Human0.89886773
120BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.89601231
121ESR2_21235772_ChIP-Seq_MCF-7_Human0.88822769
122SMAD4_21741376_ChIP-Seq_EPCs_Human0.87841661
123KLF4_19829295_ChIP-Seq_ESCs_Human0.87800006
124KDM2B_26808549_Chip-Seq_JURKAT_Human0.86880966
125AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.83408687
126* RUNX2_22187159_ChIP-Seq_PCA_Human0.82134479
127P300_19829295_ChIP-Seq_ESCs_Human0.80905232
128NR3C1_21868756_ChIP-Seq_MCF10A_Human0.80158772
129OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.80077948
130* KDM2B_26808549_Chip-Seq_DND41_Human0.76430381
131* TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.75818120
132VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.75771916

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity6.79289647
2* MP0003635_abnormal_synaptic_transmissio4.41609547
3* MP0009046_muscle_twitch4.38917722
4MP0009745_abnormal_behavioral_response3.63797694
5MP0004270_analgesia3.37394138
6MP0003880_abnormal_central_pattern3.32430834
7MP0002063_abnormal_learning/memory/cond3.27234193
8* MP0002064_seizures3.26009467
9MP0002272_abnormal_nervous_system3.17286246
10MP0002822_catalepsy3.13217574
11* MP0008569_lethality_at_weaning3.10257674
12MP0010386_abnormal_urinary_bladder2.89884186
13MP0002572_abnormal_emotion/affect_behav2.85802355
14MP0001968_abnormal_touch/_nociception2.84958169
15MP0002734_abnormal_mechanical_nocicepti2.63241745
16MP0005423_abnormal_somatic_nervous2.58895153
17MP0001486_abnormal_startle_reflex2.55595844
18MP0004145_abnormal_muscle_electrophysio2.47643725
19MP0001501_abnormal_sleep_pattern2.41251675
20* MP0002067_abnormal_sensory_capabilities2.34028129
21MP0001440_abnormal_grooming_behavior2.33071041
22MP0002736_abnormal_nociception_after2.10001813
23MP0002184_abnormal_innervation2.07318261
24MP0002909_abnormal_adrenal_gland2.00050823
25MP0002735_abnormal_chemical_nociception1.94224640
26MP0005386_behavior/neurological_phenoty1.90286010
27MP0004924_abnormal_behavior1.90286010
28MP0001970_abnormal_pain_threshold1.83791808
29MP0003329_amyloid_beta_deposits1.82901123
30MP0002733_abnormal_thermal_nociception1.82447423
31MP0002557_abnormal_social/conspecific_i1.81694832
32MP0004885_abnormal_endolymph1.81124135
33MP0006035_abnormal_mitochondrial_morpho1.74453362
34MP0003879_abnormal_hair_cell1.62521974
35MP0004811_abnormal_neuron_physiology1.62398408
36MP0003633_abnormal_nervous_system1.60934319
37MP0004142_abnormal_muscle_tone1.58580577
38MP0000955_abnormal_spinal_cord1.54950047
39* MP0002066_abnormal_motor_capabilities/c1.54507561
40MP0004147_increased_porphyrin_level1.47987286
41MP0009780_abnormal_chondrocyte_physiolo1.46605321
42MP0003631_nervous_system_phenotype1.43636530
43MP0003632_abnormal_nervous_system1.42482421
44MP0004742_abnormal_vestibular_system1.29743318
45MP0008872_abnormal_physiological_respon1.28786330
46MP0004858_abnormal_nervous_system1.28436323
47MP0002638_abnormal_pupillary_reflex1.27970997
48MP0003690_abnormal_glial_cell1.27636192
49MP0000013_abnormal_adipose_tissue1.26469537
50MP0002882_abnormal_neuron_morphology1.26288955
51MP0001984_abnormal_olfaction1.22856507
52MP0001502_abnormal_circadian_rhythm1.21946764
53MP0000778_abnormal_nervous_system1.21595962
54MP0004043_abnormal_pH_regulation1.21272869
55MP0000569_abnormal_digit_pigmentation1.14858400
56MP0003283_abnormal_digestive_organ1.13745480
57MP0008875_abnormal_xenobiotic_pharmacok1.11341858
58MP0000920_abnormal_myelination1.10559276
59MP0008874_decreased_physiological_sensi1.09936570
60* MP0002152_abnormal_brain_morphology1.07784328
61MP0005646_abnormal_pituitary_gland1.05937134
62MP0002009_preneoplasia1.03602136
63MP0003172_abnormal_lysosome_physiology1.03001877
64MP0004215_abnormal_myocardial_fiber1.01101147
65MP0001177_atelectasis1.00331418
66MP0003045_fibrosis0.99200620
67MP0003303_peritoneal_inflammation0.99132176
68MP0002229_neurodegeneration0.96189875
69MP0006276_abnormal_autonomic_nervous0.95487442
70MP0005167_abnormal_blood-brain_barrier0.94397226
71MP0004084_abnormal_cardiac_muscle0.94115720
72MP0008961_abnormal_basal_metabolism0.92931236
73MP0001188_hyperpigmentation0.92135327
74MP0003137_abnormal_impulse_conducting0.90727682
75MP0002069_abnormal_eating/drinking_beha0.87177498
76MP0001348_abnormal_lacrimal_gland0.86885405
77MP0003075_altered_response_to0.86473213
78MP0004130_abnormal_muscle_cell0.85439293
79MP0004510_myositis0.84805218
80MP0004085_abnormal_heartbeat0.84257471
81MP0000604_amyloidosis0.83836197
82MP0000751_myopathy0.82310755
83MP0005535_abnormal_body_temperature0.82186107
84MP0003787_abnormal_imprinting0.79239159
85MP0004484_altered_response_of0.79018935
86MP0002089_abnormal_postnatal_growth/wei0.78327742
87MP0005645_abnormal_hypothalamus_physiol0.76599106
88MP0000015_abnormal_ear_pigmentation0.76403056
89MP0005409_darkened_coat_color0.72520671
90MP0004233_abnormal_muscle_weight0.71999962
91MP0001299_abnormal_eye_distance/0.70777580
92MP0008057_abnormal_DNA_replication0.70315081
93MP0001851_eye_inflammation0.70024985
94MP0005166_decreased_susceptibility_to0.68119382
95MP0003634_abnormal_glial_cell0.67851980
96MP0001485_abnormal_pinna_reflex0.66523172
97MP0005187_abnormal_penis_morphology0.65173499
98MP0005671_abnormal_response_to0.63415054
99MP0010234_abnormal_vibrissa_follicle0.63341153
100MP0003183_abnormal_peptide_metabolism0.63296094
101MP0001835_abnormal_antigen_presentation0.62740358
102MP0001963_abnormal_hearing_physiology0.62456080
103MP0003763_abnormal_thymus_physiology0.62299704
104* MP0002083_premature_death0.60394831
105* MP0010769_abnormal_survival0.60382428
106MP0005551_abnormal_eye_electrophysiolog0.60308540
107MP0003646_muscle_fatigue0.59305184
108MP0005595_abnormal_vascular_smooth0.58333503
109* MP0010768_mortality/aging0.57135295
110MP0005083_abnormal_biliary_tract0.55660153
111MP0000747_muscle_weakness0.54340668
112MP0005620_abnormal_muscle_contractility0.54299906
113* MP0002082_postnatal_lethality0.53801535
114* MP0010770_preweaning_lethality0.53801535
115MP0003868_abnormal_feces_composition0.53267209
116MP0002166_altered_tumor_susceptibility0.52135466
117MP0005310_abnormal_salivary_gland0.52008396
118* MP0003956_abnormal_body_size0.51385446
119MP0005387_immune_system_phenotype0.51279698
120MP0001790_abnormal_immune_system0.51279698
121MP0003866_abnormal_defecation0.50812535
122MP0001943_abnormal_respiration0.50576551
123MP0005623_abnormal_meninges_morphology0.50349548
124MP0000003_abnormal_adipose_tissue0.49054154
125MP0001765_abnormal_ion_homeostasis0.49024450
126MP0002752_abnormal_somatic_nervous0.47824016
127MP0004036_abnormal_muscle_relaxation0.47561792
128MP0002090_abnormal_vision0.46150374

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)7.38024117
2Myokymia (HP:0002411)7.22574772
3Progressive cerebellar ataxia (HP:0002073)6.66626450
4Visual hallucinations (HP:0002367)6.03286587
5Focal seizures (HP:0007359)5.96311721
6Atonic seizures (HP:0010819)4.95920908
7Febrile seizures (HP:0002373)4.83232568
8* Gaze-evoked nystagmus (HP:0000640)4.67727180
9* Action tremor (HP:0002345)4.59581763
10Hemiplegia (HP:0002301)4.56347308
11Annular pancreas (HP:0001734)4.24674585
12Absence seizures (HP:0002121)4.19103150
13Epileptic encephalopathy (HP:0200134)4.16380594
14Poor eye contact (HP:0000817)4.06284796
15Genetic anticipation (HP:0003743)4.04957667
16Abnormality of the lower motor neuron (HP:0002366)3.81820618
17* Dysdiadochokinesis (HP:0002075)3.72344949
18Abnormal social behavior (HP:0012433)3.71371283
19Impaired social interactions (HP:0000735)3.71371283
20Dialeptic seizures (HP:0011146)3.66134028
21* Dysmetria (HP:0001310)3.65556307
22Tetraplegia (HP:0002445)3.62519831
23* Impaired smooth pursuit (HP:0007772)3.61422286
24Generalized tonic-clonic seizures (HP:0002069)3.60137263
25Hemiparesis (HP:0001269)3.57458335
26Status epilepticus (HP:0002133)3.51824578
27Depression (HP:0000716)3.51127415
28Abnormality of binocular vision (HP:0011514)3.50753905
29Diplopia (HP:0000651)3.50753905
30* Abnormality of ocular smooth pursuit (HP:0000617)3.50667706
31Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)3.46557940
32Degeneration of the lateral corticospinal tracts (HP:0002314)3.46557940
33* Intention tremor (HP:0002080)3.27840872
34Anxiety (HP:0000739)3.26919296
35Neurofibrillary tangles (HP:0002185)3.10685190
36Ventricular fibrillation (HP:0001663)3.08526000
37Impaired vibration sensation in the lower limbs (HP:0002166)3.06011585
38Postural instability (HP:0002172)2.99842312
39Abnormal eating behavior (HP:0100738)2.90357013
40* Broad-based gait (HP:0002136)2.84402816
41Stereotypic behavior (HP:0000733)2.80678787
42Bundle branch block (HP:0011710)2.77754691
43* Truncal ataxia (HP:0002078)2.72113894
44Pointed chin (HP:0000307)2.68746175
45Supranuclear gaze palsy (HP:0000605)2.67791916
46Cerebral inclusion bodies (HP:0100314)2.67627027
47Lower limb asymmetry (HP:0100559)2.66896393
48Ankle clonus (HP:0011448)2.63528392
49Urinary bladder sphincter dysfunction (HP:0002839)2.58238537
50Agitation (HP:0000713)2.47885647
51Spastic gait (HP:0002064)2.47744596
52Papilledema (HP:0001085)2.42349685
53Spinal canal stenosis (HP:0003416)2.41540205
54Impaired vibratory sensation (HP:0002495)2.38111890
55Torticollis (HP:0000473)2.35310351
56Mutism (HP:0002300)2.34374147
57Resting tremor (HP:0002322)2.31065577
58Focal dystonia (HP:0004373)2.30801861
59Lower limb muscle weakness (HP:0007340)2.29714804
60Neuronal loss in central nervous system (HP:0002529)2.27458210
61Amyotrophic lateral sclerosis (HP:0007354)2.26504020
62Bradykinesia (HP:0002067)2.22537835
63* Abnormality of saccadic eye movements (HP:0000570)2.20425542
64Autoamputation (HP:0001218)2.18178019
65Drooling (HP:0002307)2.17165887
66Excessive salivation (HP:0003781)2.17165887
67Hyperventilation (HP:0002883)2.16594173
68Insidious onset (HP:0003587)2.15683012
69Termporal pattern (HP:0011008)2.15683012
70Clonus (HP:0002169)2.14294065
71Abnormality of the corticospinal tract (HP:0002492)2.14083615
72Incomplete penetrance (HP:0003829)2.12504535
73* Gait ataxia (HP:0002066)2.12194997
74Global brain atrophy (HP:0002283)2.09713986
75Urinary urgency (HP:0000012)2.09538524
76Megalencephaly (HP:0001355)2.07929770
77Obstructive sleep apnea (HP:0002870)2.07850319
78Psychosis (HP:0000709)2.07419457
79Abnormality of the periventricular white matter (HP:0002518)2.02255806
80Epileptiform EEG discharges (HP:0011182)2.01106768
81Spastic tetraparesis (HP:0001285)2.00712751
82Increased circulating renin level (HP:0000848)1.99188084
83EEG with generalized epileptiform discharges (HP:0011198)1.98360176
84Myotonia (HP:0002486)1.98319824
85* Limb ataxia (HP:0002070)1.97955844
86Fetal akinesia sequence (HP:0001989)1.97746609
87Confusion (HP:0001289)1.97712504
88Slow saccadic eye movements (HP:0000514)1.94548000
89Amblyopia (HP:0000646)1.93245176
90* Horizontal nystagmus (HP:0000666)1.92040546
91Distal upper limb amyotrophy (HP:0007149)1.91903628
92Upper limb amyotrophy (HP:0009129)1.91903628
93Hypsarrhythmia (HP:0002521)1.91253886
94Short chin (HP:0000331)1.91211257
95Craniofacial dystonia (HP:0012179)1.89116584
96Neoplasm of the heart (HP:0100544)1.88123364
97* Dysmetric saccades (HP:0000641)1.88101116
98Absent speech (HP:0001344)1.87378990
99Oligodactyly (hands) (HP:0001180)1.83912527
100Prolonged QT interval (HP:0001657)1.83036681
101Memory impairment (HP:0002354)1.82152731
102Abnormal EKG (HP:0003115)1.81792689
103Aqueductal stenosis (HP:0002410)1.81770158
104Ocular albinism (HP:0001107)1.80634932
105Morphological abnormality of the pyramidal tract (HP:0002062)1.79644103
106Progressive inability to walk (HP:0002505)1.78071523
107Apathy (HP:0000741)1.76777153
108Hand muscle atrophy (HP:0009130)1.74194128
109Insomnia (HP:0100785)1.72978773
110* Scanning speech (HP:0002168)1.72432323
111* Slow progression (HP:0003677)1.72307035
112Macroorchidism (HP:0000053)1.71785342
113Iris hypopigmentation (HP:0007730)1.71304636
114Rigidity (HP:0002063)1.70939944
115Hypoplastic nipples (HP:0002557)1.69390772
116Syncope (HP:0001279)1.65741544
117* Dysarthria (HP:0001260)1.62163557
118Paraplegia (HP:0010550)1.57882592
119Diminished motivation (HP:0000745)1.57157776
120Athetosis (HP:0002305)1.56989758
121Hyperlipoproteinemia (HP:0010980)1.53014154
122Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.49745684
123Lower limb amyotrophy (HP:0007210)1.49295916
124Rapidly progressive (HP:0003678)1.47974996
125Spastic paraplegia (HP:0001258)1.47513252
126Relative macrocephaly (HP:0004482)1.47460101
127Colitis (HP:0002583)1.46648546
128* Postural tremor (HP:0002174)1.46146184
129Menstrual irregularities (HP:0000858)1.44496907

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NTRK33.96053441
2CAMKK23.95111373
3EPHA43.45949806
4MAP3K93.26549641
5RIPK13.16821422
6CAMKK13.03403178
7DAPK22.76299136
8MAP3K42.57130090
9RIPK42.33403616
10MINK12.33253535
11STK382.22106880
12NTRK22.16451182
13WNK12.14137477
14PAK62.09579571
15MAP2K71.82393254
16MAP2K41.80480484
17CDK191.78589339
18PRKD31.71219318
19KSR21.67222722
20PRPF4B1.65380059
21TYRO31.51793895
22NTRK11.51462907
23TNIK1.47935524
24MARK11.44012717
25CDK51.38474283
26JAK11.36931496
27PINK11.36899363
28SGK21.35633582
29DAPK11.33628470
30SGK31.32294914
31SGK4941.28973678
32SGK2231.28973678
33CAMK11.28858347
34PRKCG1.25430983
35STK111.24260850
36FES1.23954212
37MAPK121.22380323
38PRKCH1.21755190
39AKT31.20491012
40SIK21.18384016
41EEF2K1.15232143
42CAMK1D1.12980236
43KSR11.12221642
44OXSR11.10612348
45MAP3K131.10264845
46ALK1.09633834
47CDK121.07569774
48CAMK41.04802942
49UHMK11.00744163
50PDK10.94752424
51MAP3K20.93172944
52RET0.89048856
53TAOK10.88914773
54GRK50.88081028
55SGK10.86473452
56CAMK1G0.86401884
57PNCK0.86332432
58CAMK2B0.85438791
59CDK150.84992401
60SYK0.84020689
61PDPK10.82455553
62CDK180.81953867
63CDC42BPA0.80766933
64CAMK2G0.76591497
65PDK20.76544253
66MARK20.74639641
67CAMK2A0.74465346
68CDK11A0.73130337
69ITK0.72030994
70FGFR30.71156134
71LATS20.70254162
72BLK0.69545787
73CDK140.69397146
74MAPK130.68436854
75TNK20.67619815
76PHKG10.67487788
77PHKG20.67487788
78BMPR20.66898749
79BRAF0.66323568
80MYLK0.63743337
81JAK20.63389581
82NEK60.62050176
83DYRK1A0.61897167
84SCYL20.60135870
85* RPS6KA30.59554982
86CAMK2D0.57782957
87MAPK70.57280761
88PRKG20.56209867
89MAPKAPK50.54215430
90RAF10.53986840
91FER0.53427560
92PTK60.53127821
93MAP3K140.53121822
94CSNK1G20.52912747
95ARAF0.52289191
96HIPK20.51938418
97LMTK20.51828203
98TRIB30.51208449
99PRKD20.49756217
100RPS6KB10.49545765
101PLK20.49289483
102TRPM70.49083107
103CSNK1A1L0.47629149
104MOS0.47410854
105MAP3K70.47197196
106MAPK100.47053991
107MAP3K120.45649933
108CDK30.45263174
109PTK2B0.45092806
110MAP3K10.43920424
111CASK0.43338447
112DMPK0.42547926
113* FYN0.42163521
114PDGFRA0.42050728
115MAPK110.41684285
116ROCK20.40849655
117BTK0.40154079
118PTK20.39269409
119WNK30.38681280
120FGFR20.38518940
121BMX0.38270281
122MAPK40.37978191
123* PRKG10.36974763
124MTOR0.36936139
125PRKCZ0.35618051
126LCK0.35217138
127MAP2K10.32766272
128PRKCA0.32606874
129MAP4K10.32582466
130PRKCB0.32474747
131SRC0.32419951
132ICK0.31754571
133DAPK30.30889247

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050334.02913707
2* Glutamatergic synapse_Homo sapiens_hsa047242.91989364
3* Long-term potentiation_Homo sapiens_hsa047202.82331085
4GABAergic synapse_Homo sapiens_hsa047272.72433617
5* Circadian entrainment_Homo sapiens_hsa047132.69336800
6* Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.66945711
7Synaptic vesicle cycle_Homo sapiens_hsa047212.66863467
8Morphine addiction_Homo sapiens_hsa050322.61596385
9Amphetamine addiction_Homo sapiens_hsa050312.43880493
10Olfactory transduction_Homo sapiens_hsa047402.38058465
11Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.25047379
12* Salivary secretion_Homo sapiens_hsa049702.17787688
13Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049642.15249638
14* Long-term depression_Homo sapiens_hsa047302.10944574
15Taste transduction_Homo sapiens_hsa047422.10767271
16Insulin secretion_Homo sapiens_hsa049111.93681144
17* Aldosterone synthesis and secretion_Homo sapiens_hsa049251.92922120
18Nitrogen metabolism_Homo sapiens_hsa009101.87746632
19* Dopaminergic synapse_Homo sapiens_hsa047281.87067784
20* Gastric acid secretion_Homo sapiens_hsa049711.84310683
21Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.72918182
22* Cholinergic synapse_Homo sapiens_hsa047251.70090050
23Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.69501054
24Type II diabetes mellitus_Homo sapiens_hsa049301.56603407
25* Oxytocin signaling pathway_Homo sapiens_hsa049211.56343900
26* Calcium signaling pathway_Homo sapiens_hsa040201.55474908
27* Phosphatidylinositol signaling system_Homo sapiens_hsa040701.49485350
28cAMP signaling pathway_Homo sapiens_hsa040241.46239746
29Cocaine addiction_Homo sapiens_hsa050301.45020127
30Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.40257486
31* Renin secretion_Homo sapiens_hsa049241.27534573
32* GnRH signaling pathway_Homo sapiens_hsa049121.22060974
33* Gap junction_Homo sapiens_hsa045401.15846150
34* Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.11817524
35* Pancreatic secretion_Homo sapiens_hsa049721.11723989
36* Estrogen signaling pathway_Homo sapiens_hsa049151.10877675
37* Serotonergic synapse_Homo sapiens_hsa047261.09943909
38Phospholipase D signaling pathway_Homo sapiens_hsa040721.06537435
39* cGMP-PKG signaling pathway_Homo sapiens_hsa040221.05647629
40Carbohydrate digestion and absorption_Homo sapiens_hsa049731.01250915
41Bile secretion_Homo sapiens_hsa049761.00544825
42Glioma_Homo sapiens_hsa052140.95530215
43* Thyroid hormone synthesis_Homo sapiens_hsa049180.94218159
44Inositol phosphate metabolism_Homo sapiens_hsa005620.92082604
45Melanogenesis_Homo sapiens_hsa049160.92011888
46B cell receptor signaling pathway_Homo sapiens_hsa046620.90709792
47Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.89357971
48Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.86300559
49Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.83795454
50ErbB signaling pathway_Homo sapiens_hsa040120.82937501
51Choline metabolism in cancer_Homo sapiens_hsa052310.82208366
52Dilated cardiomyopathy_Homo sapiens_hsa054140.80041838
53Dorso-ventral axis formation_Homo sapiens_hsa043200.77282824
54Cardiac muscle contraction_Homo sapiens_hsa042600.77103245
55Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.76932229
56* Vascular smooth muscle contraction_Homo sapiens_hsa042700.76922514
57Circadian rhythm_Homo sapiens_hsa047100.75912576
58Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.72805693
59mTOR signaling pathway_Homo sapiens_hsa041500.72121656
60Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.72070067
61Longevity regulating pathway - mammal_Homo sapiens_hsa042110.71538705
62Pentose phosphate pathway_Homo sapiens_hsa000300.67970438
63MAPK signaling pathway_Homo sapiens_hsa040100.67485251
64Thyroid hormone signaling pathway_Homo sapiens_hsa049190.67482949
65Neurotrophin signaling pathway_Homo sapiens_hsa047220.63819570
66* Oocyte meiosis_Homo sapiens_hsa041140.63119189
67Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.61519700
68Arginine biosynthesis_Homo sapiens_hsa002200.59400242
69VEGF signaling pathway_Homo sapiens_hsa043700.59074555
70Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.58942105
71Prion diseases_Homo sapiens_hsa050200.57296227
72Axon guidance_Homo sapiens_hsa043600.55548554
73Rap1 signaling pathway_Homo sapiens_hsa040150.54882088
74Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.54682406
75Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.51876002
76Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.51432862
77Osteoclast differentiation_Homo sapiens_hsa043800.51243679
78Non-small cell lung cancer_Homo sapiens_hsa052230.50964144
79Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.49701172
80Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.49329894
81Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.48359896
82Collecting duct acid secretion_Homo sapiens_hsa049660.47496377
83Renin-angiotensin system_Homo sapiens_hsa046140.47430631
84Sphingolipid signaling pathway_Homo sapiens_hsa040710.46757872
85Chemokine signaling pathway_Homo sapiens_hsa040620.44768396
86Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.44544470
87Endocytosis_Homo sapiens_hsa041440.43210182
88Fatty acid biosynthesis_Homo sapiens_hsa000610.41401019
89HIF-1 signaling pathway_Homo sapiens_hsa040660.41381347
90Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.40639075
91Fructose and mannose metabolism_Homo sapiens_hsa000510.39425325
92T cell receptor signaling pathway_Homo sapiens_hsa046600.38807831
93Tuberculosis_Homo sapiens_hsa051520.38317194
94Ovarian steroidogenesis_Homo sapiens_hsa049130.37719574
95Endometrial cancer_Homo sapiens_hsa052130.37391060
96* Glucagon signaling pathway_Homo sapiens_hsa049220.37320874
97Amoebiasis_Homo sapiens_hsa051460.37296990
98Alcoholism_Homo sapiens_hsa050340.37243117
99Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.36603627
100Mineral absorption_Homo sapiens_hsa049780.34722229
101Leukocyte transendothelial migration_Homo sapiens_hsa046700.33692819
102FoxO signaling pathway_Homo sapiens_hsa040680.33433454
103Vitamin B6 metabolism_Homo sapiens_hsa007500.33136655
104Ras signaling pathway_Homo sapiens_hsa040140.32930281
105Insulin signaling pathway_Homo sapiens_hsa049100.31742329
106Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.31574592
107Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.31167927
108African trypanosomiasis_Homo sapiens_hsa051430.30262012
109Prolactin signaling pathway_Homo sapiens_hsa049170.29319304
110Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.29178579
111Glycerophospholipid metabolism_Homo sapiens_hsa005640.28886711
112Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.28833671
113* Platelet activation_Homo sapiens_hsa046110.28455090
114Wnt signaling pathway_Homo sapiens_hsa043100.28258962
115Toxoplasmosis_Homo sapiens_hsa051450.28038112
116Leishmaniasis_Homo sapiens_hsa051400.24960257
117Renal cell carcinoma_Homo sapiens_hsa052110.24037307
118Glycerolipid metabolism_Homo sapiens_hsa005610.23110550
119Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.22789471
120Central carbon metabolism in cancer_Homo sapiens_hsa052300.22551202

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