ITPR2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene belongs to the inositol 1,4,5-triphosphate receptor family, whose members are second messenger intracellular calcium release channels. These proteins mediate a rise in cytoplasmic calcium in response to receptor activated production of inositol triphosphate. Inositol triphosphate receptor-mediated signaling is involved in many processes including cell migration, cell division, smooth muscle contraction, and neuronal signaling. This protein is a type 2 receptor that consists of a cytoplasmic amino-terminus that binds inositol triphosphate, six membrane-spanning helices that contribute to the ion pore, and a short cytoplasmic carboxy-terminus. A mutation in this gene has been associated with anhidrosis, suggesting that intracellular calcium release mediated by this protein is required for eccrine sweat production. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1activated T cell proliferation (GO:0050798)5.12455294
2positive regulation of gamma-delta T cell activation (GO:0046645)5.01473645
3regulation of gamma-delta T cell differentiation (GO:0045586)4.67108523
4regulation of gamma-delta T cell activation (GO:0046643)4.35253699
5detection of molecule of bacterial origin (GO:0032490)4.35237551
6regulation of protein activation cascade (GO:2000257)4.20159999
7regulation of complement activation (GO:0030449)4.17172191
8negative T cell selection (GO:0043383)4.13535515
9positive thymic T cell selection (GO:0045059)4.11845010
10positive T cell selection (GO:0043368)4.10682186
11regulation of T cell tolerance induction (GO:0002664)3.98184031
12antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.92120842
13antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.92120842
14regulation of apoptotic cell clearance (GO:2000425)3.88454510
15positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.82944635
16T cell selection (GO:0045058)3.73326280
17negative regulation of fibrinolysis (GO:0051918)3.72414615
18negative thymic T cell selection (GO:0045060)3.67297138
19antigen processing and presentation of endogenous antigen (GO:0019883)3.65612856
20leukocyte aggregation (GO:0070486)3.64214691
21low-density lipoprotein particle remodeling (GO:0034374)3.53378312
22thymic T cell selection (GO:0045061)3.52512842
23tolerance induction (GO:0002507)3.45794297
24antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.44832890
25cellular extravasation (GO:0045123)3.41589934
26phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)3.37261968
27negative regulation of protein activation cascade (GO:2000258)3.36670212
28negative regulation of cell killing (GO:0031342)3.33556607
29negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.33556607
30histone H3-K36 demethylation (GO:0070544)3.27350063
31regulation of fibrinolysis (GO:0051917)3.23048585
32detection of external biotic stimulus (GO:0098581)3.12625728
33T cell receptor signaling pathway (GO:0050852)3.12313835
34macrophage activation involved in immune response (GO:0002281)3.11427577
35positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.09106603
36regulation of macrophage chemotaxis (GO:0010758)3.08400756
37positive regulation of chemokine secretion (GO:0090197)3.05526233
38negative regulation of complement activation (GO:0045916)3.05364314
39protein-lipid complex remodeling (GO:0034368)3.03432335
40macromolecular complex remodeling (GO:0034367)3.03432335
41plasma lipoprotein particle remodeling (GO:0034369)3.03432335
42complement activation, classical pathway (GO:0006958)3.01356519
43cholesterol efflux (GO:0033344)3.00519638
44T cell costimulation (GO:0031295)2.98092292
45regulation of humoral immune response (GO:0002920)2.93869511
46positive regulation of tolerance induction (GO:0002645)2.93189108
47lymphocyte costimulation (GO:0031294)2.91569843
48pinocytosis (GO:0006907)2.90680615
49regulation of interleukin-2 biosynthetic process (GO:0045076)2.90276760
50plasma lipoprotein particle organization (GO:0071827)2.90165988
51antigen receptor-mediated signaling pathway (GO:0050851)2.89945060
52T cell migration (GO:0072678)2.88615693
53regulation of hypersensitivity (GO:0002883)2.87468702
54positive regulation of phagocytosis (GO:0050766)2.86147222
55regulation of extracellular matrix disassembly (GO:0010715)2.85924653
56protein activation cascade (GO:0072376)2.85240694
57high-density lipoprotein particle remodeling (GO:0034375)2.85105623
58valine metabolic process (GO:0006573)2.81815458
59protein-lipid complex subunit organization (GO:0071825)2.81707808
60microglial cell activation (GO:0001774)2.79784039
61response to interleukin-15 (GO:0070672)2.79479932
62blood coagulation, intrinsic pathway (GO:0007597)2.76502036
63regulation of tolerance induction (GO:0002643)2.76232242
64reverse cholesterol transport (GO:0043691)2.74864103
65complement activation (GO:0006956)2.74065514
66fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.72568442
67regulation of B cell receptor signaling pathway (GO:0050855)2.70975896
68positive regulation of blood coagulation (GO:0030194)2.70303639
69positive regulation of hemostasis (GO:1900048)2.70303639
70positive regulation of myeloid leukocyte mediated immunity (GO:0002888)2.69620515
71regulation of cholesterol esterification (GO:0010872)2.69292083
72negative regulation of thymocyte apoptotic process (GO:0070244)2.69278815
73positive regulation of interleukin-2 production (GO:0032743)2.68563425
74positive regulation of cellular amide metabolic process (GO:0034250)2.68371545
75detection of biotic stimulus (GO:0009595)2.67617858
76positive regulation of B cell differentiation (GO:0045579)2.67356896
77positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.66915225
78lipoprotein metabolic process (GO:0042157)2.66716628
79negative regulation of humoral immune response (GO:0002921)2.66567201
80alpha-linolenic acid metabolic process (GO:0036109)2.66527514
81nuclear pore complex assembly (GO:0051292)2.66169078
82plasma lipoprotein particle clearance (GO:0034381)2.65797674
83JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.65611145
84regulation of chemokine secretion (GO:0090196)2.65603009
85interferon-gamma production (GO:0032609)2.65255971
86interkinetic nuclear migration (GO:0022027)2.64901270
87positive regulation of fatty acid beta-oxidation (GO:0032000)2.64061074
88negative regulation of fatty acid transport (GO:2000192)2.63518826
89histone H3-K4 trimethylation (GO:0080182)2.63292327
90positive regulation of histone deacetylation (GO:0031065)2.61209885
91regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.60262229
92positive regulation of interferon-alpha production (GO:0032727)2.59545431
93regulation of B cell differentiation (GO:0045577)2.59199944
94dicarboxylic acid biosynthetic process (GO:0043650)2.58397804
95germinal center formation (GO:0002467)2.57837866
96* cellular response to ethanol (GO:0071361)2.57807033
97regulation of endothelial cell chemotaxis (GO:2001026)2.56533678
98low-density lipoprotein particle clearance (GO:0034383)2.55645039
99negative regulation of cholesterol transport (GO:0032375)2.55320362
100negative regulation of sterol transport (GO:0032372)2.55320362
101B cell receptor signaling pathway (GO:0050853)2.55230748
102regulation of interferon-beta biosynthetic process (GO:0045357)2.52392097
103positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.51887295
104T-helper cell differentiation (GO:0042093)2.51751310
105CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)2.51751310
106monoubiquitinated protein deubiquitination (GO:0035520)2.51512456
107positive regulation of coagulation (GO:0050820)2.51111430
108regulation of isotype switching to IgG isotypes (GO:0048302)2.50435943
109embryonic process involved in female pregnancy (GO:0060136)2.50361081
110cellular response to interleukin-15 (GO:0071350)2.49017949
111phospholipid homeostasis (GO:0055091)2.48497097
112positive regulation of interleukin-8 biosynthetic process (GO:0045416)2.47951063
113Rap protein signal transduction (GO:0032486)2.47644721
114detection of other organism (GO:0098543)2.46598892
115heterotypic cell-cell adhesion (GO:0034113)2.45691290
116macrophage activation (GO:0042116)2.45338250
117B cell homeostasis (GO:0001782)2.44180474
118regulation of phagocytosis (GO:0050764)2.43066855
119iron ion import (GO:0097286)2.42592637
120response to muramyl dipeptide (GO:0032495)2.41394258
121mannose metabolic process (GO:0006013)2.40673819
122growth hormone receptor signaling pathway (GO:0060396)2.39987889
123negative regulation of macrophage derived foam cell differentiation (GO:0010745)2.39568151
124regulation of alkaline phosphatase activity (GO:0010692)2.38935322
125alpha-beta T cell differentiation (GO:0046632)2.38770960
126hepatocyte apoptotic process (GO:0097284)2.38370712
127positive regulation of granulocyte differentiation (GO:0030854)2.38024543
128regulation of alpha-beta T cell proliferation (GO:0046640)2.37309614
129regulation of interferon-alpha production (GO:0032647)2.36484638
130regulation of establishment of cell polarity (GO:2000114)2.36098937
131negative regulation of T cell apoptotic process (GO:0070233)2.35739757
132regulation of cholesterol homeostasis (GO:2000188)2.35715680
133positive regulation of heterotypic cell-cell adhesion (GO:0034116)2.34586836
134response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.34156818
135response to host immune response (GO:0052572)2.34156818
136cytoplasmic mRNA processing body assembly (GO:0033962)2.32753479
137alpha-beta T cell activation (GO:0046631)2.32131109
138regulation of interleukin-12 biosynthetic process (GO:0045075)2.32117733
139positive regulation of fatty acid oxidation (GO:0046321)2.31608187
140acetyl-CoA metabolic process (GO:0006084)2.29951625
141regulation of triglyceride catabolic process (GO:0010896)2.28502869
142plasma lipoprotein particle assembly (GO:0034377)2.27522512
143positive regulation of humoral immune response (GO:0002922)2.26075257
144regulation of sequestering of triglyceride (GO:0010889)2.25874362
145regulation of regulatory T cell differentiation (GO:0045589)2.24902420
146very-low-density lipoprotein particle assembly (GO:0034379)2.22345172
147CD4-positive, alpha-beta T cell differentiation (GO:0043367)2.22047293
148protein-lipid complex assembly (GO:0065005)2.21216360
149response to laminar fluid shear stress (GO:0034616)2.21197555
150triglyceride-rich lipoprotein particle remodeling (GO:0034370)2.21151354
151T cell proliferation (GO:0042098)2.19085675
152platelet-derived growth factor receptor signaling pathway (GO:0048008)2.16937942
153phospholipid efflux (GO:0033700)2.16837463
154complement activation, alternative pathway (GO:0006957)2.13594652
155response to lipoprotein particle (GO:0055094)2.13172268
156positive regulation by symbiont of host defense response (GO:0052509)2.13128379
157modulation by symbiont of host defense response (GO:0052031)2.13128379
158modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.13128379
159modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.13128379
160positive regulation by organism of defense response of other organism involved in symbiotic interact2.13128379
161modulation by symbiont of host immune response (GO:0052553)2.13128379
162urea cycle (GO:0000050)2.12827030
163urea metabolic process (GO:0019627)2.12827030
164transcytosis (GO:0045056)2.12616723
165regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.11734941
166regulation of B cell proliferation (GO:0030888)2.11535704
167negative regulation of bone resorption (GO:0045779)2.10974806
168lymphocyte homeostasis (GO:0002260)2.10614329
169positive regulation of cholesterol efflux (GO:0010875)2.10530711
170positive regulation of alpha-beta T cell proliferation (GO:0046641)2.09813813
171T cell differentiation (GO:0030217)2.09734808
172fatty acid beta-oxidation (GO:0006635)2.09232218
173glyoxylate metabolic process (GO:0046487)2.08617593
174positive regulation of sterol transport (GO:0032373)2.08476345
175positive regulation of cholesterol transport (GO:0032376)2.08476345

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP3_17237761_ChIP-ChIP_TREG_Mouse6.03998984
2STAT6_20620947_ChIP-Seq_CD4_POS_T_Human4.12761621
3IRF8_22096565_ChIP-ChIP_GC-B_Human3.36086693
4RUNX_20019798_ChIP-Seq_JUKART_Human3.24460225
5ESR1_17901129_ChIP-ChIP_LIVER_Mouse3.12146009
6BP1_19119308_ChIP-ChIP_Hs578T_Human2.78294227
7STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.48678785
8IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.47871731
9STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.47322684
10LXR_22158963_ChIP-Seq_LIVER_Mouse2.45704774
11FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.36855134
12RXR_22158963_ChIP-Seq_LIVER_Mouse2.35166552
13VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.27672371
14NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.20967817
15PPARA_22158963_ChIP-Seq_LIVER_Mouse2.12231016
16IRF8_27001747_Chip-Seq_BMDM_Mouse2.05058040
17SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.04775608
18EGR1_23403033_ChIP-Seq_LIVER_Mouse2.03561018
19SMAD_19615063_ChIP-ChIP_OVARY_Human1.94446988
20NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.89999249
21IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.89612027
22FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.83436158
23* Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.81709580
24NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.81372311
25FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.77980412
26VDR_24787735_ChIP-Seq_THP-1_Human1.72898152
27* MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.71282028
28MYB_26560356_Chip-Seq_TH2_Human1.66451112
29FOXO3_23340844_ChIP-Seq_DLD1_Human1.62983501
30SCL_19346495_ChIP-Seq_HPC-7_Human1.62739816
31IRF8_21731497_ChIP-ChIP_J774_Mouse1.59680365
32ZNF217_24962896_ChIP-Seq_MCF-7_Human1.53622055
33RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.48854187
34PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.48308685
35EGR1_19374776_ChIP-ChIP_THP-1_Human1.42995789
36PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.41633062
37* GATA3_27048872_Chip-Seq_THYMUS_Human1.39156121
38GATA2_21666600_ChIP-Seq_HMVEC_Human1.38741393
39STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.38646524
40* MAF_26560356_Chip-Seq_TH1_Human1.35308314
41ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.33459395
42* MYB_26560356_Chip-Seq_TH1_Human1.33257167
43GATA1_22025678_ChIP-Seq_K562_Human1.32528861
44CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.32183918
45* FOXA2_19822575_ChIP-Seq_HepG2_Human1.31213121
46ESR2_21235772_ChIP-Seq_MCF-7_Human1.30471203
47STAT4_19710469_ChIP-ChIP_TH1__Mouse1.28757144
48PPAR_26484153_Chip-Seq_NCI-H1993_Human1.28248380
49VDR_24763502_ChIP-Seq_THP-1_Human1.27980074
50BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.24168874
51MYB_21317192_ChIP-Seq_ERMYB_Mouse1.23447302
52E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.23326158
53* AR_21572438_ChIP-Seq_LNCaP_Human1.23311976
54TCF7_22412390_ChIP-Seq_EML_Mouse1.22866270
55SALL4_18804426_ChIP-ChIP_XEN_Mouse1.22850434
56MYC_22102868_ChIP-Seq_BL_Human1.20177008
57GATA1_19941827_ChIP-Seq_MEL_Mouse1.19704340
58UTX_26944678_Chip-Seq_JUKART_Human1.19407904
59SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.19286213
60* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.19101413
61CLOCK_20551151_ChIP-Seq_293T_Human1.18729564
62* KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.16214890
63* SPI1_23127762_ChIP-Seq_K562_Human1.15320303
64* HNF4A_19822575_ChIP-Seq_HepG2_Human1.14711599
65TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.13257659
66ESR1_20079471_ChIP-ChIP_T-47D_Human1.12815251
67TP63_17297297_ChIP-ChIP_HaCaT_Human1.12726467
68PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.12698780
69BRD4_27068464_Chip-Seq_AML-cells_Mouse1.12193892
70* SOX9_24532713_ChIP-Seq_HFSC_Mouse1.11382308
71* FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.11302252
72* CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.09503987
73GATA2_19941826_ChIP-Seq_K562_Human1.09212183
74* SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.09161316
75KDM2B_26808549_Chip-Seq_SUP-B15_Human1.07030612
76ESR1_21235772_ChIP-Seq_MCF-7_Human1.06438845
77* TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.06248025
78TCF4_18268006_ChIP-ChIP_LS174T_Human1.04627126
79GATA1_19941826_ChIP-Seq_K562_Human1.03110921
80VDR_21846776_ChIP-Seq_THP-1_Human1.03071464
81CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.02702158
82* TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.00731205
83KDM2B_26808549_Chip-Seq_DND41_Human1.00529475
84* CTNNB1_20460455_ChIP-Seq_HCT116_Human0.98018924
85PU_27001747_Chip-Seq_BMDM_Mouse0.97780135
86SPI1_23547873_ChIP-Seq_NB4_Human0.97020633
87* NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.96458065
88TP53_16413492_ChIP-PET_HCT116_Human0.96338769
89* TBX20_22328084_ChIP-Seq_HEART_Mouse0.95636506
90* TBX20_22080862_ChIP-Seq_HEART_Mouse0.95636506
91FLI1_27457419_Chip-Seq_LIVER_Mouse0.95241985
92AHR_22903824_ChIP-Seq_MCF-7_Human0.95095693
93ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.94438622
94PCGF2_27294783_Chip-Seq_NPCs_Mouse0.93064068
95* NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.91038086
96* NRF2_20460467_ChIP-Seq_MEFs_Mouse0.91038086
97SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.90993249
98SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.90993249
99TP63_23658742_ChIP-Seq_EP156T_Human0.90817170
100RXR_22108803_ChIP-Seq_LS180_Human0.90721514
101CDX2_19796622_ChIP-Seq_MESCs_Mouse0.90692243
102PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.90067599
103* SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.89989905
104PCGF2_27294783_Chip-Seq_ESCs_Mouse0.88891526
105DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.88851638
106CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.88680708
107* CJUN_26792858_Chip-Seq_BT549_Human0.88054869
108RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.87711929
109NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.86788016
110* PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.86429752
111GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.84766683
112FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.84057867
113CDX2_20551321_ChIP-Seq_CACO-2_Human0.83776259
114TCF7L2_21901280_ChIP-Seq_H4IIE_Rat0.83698737
115TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.83568504
116* KDM2B_26808549_Chip-Seq_JURKAT_Human0.83196978
117* KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.81917824
118BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.80533600
119* SMRT_27268052_Chip-Seq_Bcells_Human0.79742886
120ARNT_22903824_ChIP-Seq_MCF-7_Human0.79358486
121WT1_19549856_ChIP-ChIP_CCG9911_Human0.78664056

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003763_abnormal_thymus_physiology3.08191436
2MP0000569_abnormal_digit_pigmentation2.88134779
3MP0008057_abnormal_DNA_replication2.86182049
4MP0005360_urolithiasis2.81516899
5MP0003300_gastrointestinal_ulcer2.53607269
6MP0005365_abnormal_bile_salt2.52378993
7MP0001835_abnormal_antigen_presentation2.49535346
8MP0002139_abnormal_hepatobiliary_system2.47758450
9MP0000685_abnormal_immune_system2.46578222
10MP0001800_abnormal_humoral_immune2.45380031
11MP0005387_immune_system_phenotype2.45182478
12MP0001790_abnormal_immune_system2.45182478
13MP0005671_abnormal_response_to2.42912795
14MP0003195_calcinosis2.42057968
15MP0002166_altered_tumor_susceptibility2.28980410
16MP0003191_abnormal_cellular_cholesterol2.16180180
17MP0003724_increased_susceptibility_to2.08417549
18MP0003252_abnormal_bile_duct2.07727836
19MP0005000_abnormal_immune_tolerance2.04789899
20MP0004947_skin_inflammation1.96720077
21MP0005085_abnormal_gallbladder_physiolo1.95831346
22MP0002452_abnormal_antigen_presenting1.95556138
23MP0005670_abnormal_white_adipose1.93943367
24MP0002723_abnormal_immune_serum1.92277152
25MP0010352_gastrointestinal_tract_polyps1.89386841
26MP0003690_abnormal_glial_cell1.83646449
27MP0001873_stomach_inflammation1.82383911
28MP0004185_abnormal_adipocyte_glucose1.80759270
29MP0002420_abnormal_adaptive_immunity1.79938689
30MP0001819_abnormal_immune_cell1.76239269
31MP0006082_CNS_inflammation1.74245183
32MP0001915_intracranial_hemorrhage1.73159721
33MP0002006_tumorigenesis1.73079120
34MP0002419_abnormal_innate_immunity1.69289233
35MP0004381_abnormal_hair_follicle1.68113004
36MP0010155_abnormal_intestine_physiology1.56988528
37MP0009278_abnormal_bone_marrow1.56241167
38MP0005025_abnormal_response_to1.55510223
39MP0003436_decreased_susceptibility_to1.55492474
40MP0002009_preneoplasia1.55359051
41MP0004883_abnormal_blood_vessel1.55153223
42MP0005666_abnormal_adipose_tissue1.53665862
43MP0005076_abnormal_cell_differentiation1.53499853
44MP0005167_abnormal_blood-brain_barrier1.53165211
45MP0002398_abnormal_bone_marrow1.52086625
46MP0000716_abnormal_immune_system1.51281403
47MP0002405_respiratory_system_inflammati1.49696742
48MP0003303_peritoneal_inflammation1.48835176
49MP0004130_abnormal_muscle_cell1.48614680
50MP0009785_altered_susceptibility_to1.44711666
51MP0002933_joint_inflammation1.44035795
52MP0002254_reproductive_system_inflammat1.42728823
53MP0005451_abnormal_body_composition1.42400776
54MP0005058_abnormal_lysosome_morphology1.41956195
55MP0000609_abnormal_liver_physiology1.41807779
56MP0010329_abnormal_lipoprotein_level1.41617655
57MP0003828_pulmonary_edema1.39939418
58MP0002396_abnormal_hematopoietic_system1.39904007
59MP0001853_heart_inflammation1.39705346
60MP0000465_gastrointestinal_hemorrhage1.38135785
61MP0004510_myositis1.36920190
62MP0002148_abnormal_hypersensitivity_rea1.36348404
63MP0000703_abnormal_thymus_morphology1.34662722
64MP0000689_abnormal_spleen_morphology1.33728830
65MP0000920_abnormal_myelination1.32492172
66MP0000604_amyloidosis1.31915908
67MP0005464_abnormal_platelet_physiology1.31869148
68MP0000383_abnormal_hair_follicle1.31546090
69MP0003656_abnormal_erythrocyte_physiolo1.31476473
70MP0003453_abnormal_keratinocyte_physiol1.30224163
71MP0003045_fibrosis1.29139377
72MP0001845_abnormal_inflammatory_respons1.29065905
73MP0002138_abnormal_hepatobiliary_system1.29005417
74MP0009384_cardiac_valve_regurgitation1.28054361
75MP0009764_decreased_sensitivity_to1.27791209
76MP0002722_abnormal_immune_system1.25378154
77MP0003183_abnormal_peptide_metabolism1.22395408
78MP0001851_eye_inflammation1.22197049
79MP0010678_abnormal_skin_adnexa1.22102605
80MP0005164_abnormal_response_to1.21784810
81MP0002998_abnormal_bone_remodeling1.19808133
82MP0008875_abnormal_xenobiotic_pharmacok1.18836952
83MP0002168_other_aberrant_phenotype1.16702335
84MP0010368_abnormal_lymphatic_system1.16124280
85MP0009115_abnormal_fat_cell1.15944784
86MP0002118_abnormal_lipid_homeostasis1.13707116
87MP0008004_abnormal_stomach_pH1.12810243
88MP0003172_abnormal_lysosome_physiology1.10666420
89MP0008260_abnormal_autophagy1.09794596
90MP0008469_abnormal_protein_level1.09527377
91MP0002429_abnormal_blood_cell1.09385607
92MP0009333_abnormal_splenocyte_physiolog1.08623036
93MP0002971_abnormal_brown_adipose1.06870929
94MP0000371_diluted_coat_color1.06358196
95MP0001533_abnormal_skeleton_physiology1.06255158
96MP0003705_abnormal_hypodermis_morpholog1.05470153
97MP0005375_adipose_tissue_phenotype1.04786645
98MP0005408_hypopigmentation1.04610920
99MP0009840_abnormal_foam_cell1.01260181
100MP0006054_spinal_hemorrhage1.00465890
101* MP0001666_abnormal_nutrient_absorption0.99636318
102MP0005409_darkened_coat_color0.98335063
103MP0009763_increased_sensitivity_to0.96983660
104MP0009765_abnormal_xenobiotic_induced0.91889434
105MP0004264_abnormal_extraembryonic_tissu0.91356106
106MP0003091_abnormal_cell_migration0.91008014
107MP0002060_abnormal_skin_morphology0.89727289
108MP0003950_abnormal_plasma_membrane0.89279060
109MP0002877_abnormal_melanocyte_morpholog0.87964776
110MP0010307_abnormal_tumor_latency0.87853213
111MP0000767_abnormal_smooth_muscle0.85855715
112MP0000249_abnormal_blood_vessel0.85324521
113MP0008438_abnormal_cutaneous_collagen0.84641758
114MP0000858_altered_metastatic_potential0.84346985
115MP0004808_abnormal_hematopoietic_stem0.83462288
116MP0005334_abnormal_fat_pad0.82692482
117MP0003566_abnormal_cell_adhesion0.82344530
118MP0005621_abnormal_cell_physiology0.81616027
119MP0001661_extended_life_span0.80622191
120MP0002136_abnormal_kidney_physiology0.79523048
121MP0005023_abnormal_wound_healing0.78577632
122MP0005584_abnormal_enzyme/coenzyme_acti0.76731111
123MP0009643_abnormal_urine_homeostasis0.75965635
124MP0001545_abnormal_hematopoietic_system0.75819245
125MP0005397_hematopoietic_system_phenotyp0.75819245
126MP0002928_abnormal_bile_duct0.75581692
127* MP0003868_abnormal_feces_composition0.75442372
128MP0001216_abnormal_epidermal_layer0.75054778

Predicted human phenotypes

RankGene SetZ-score
1T lymphocytopenia (HP:0005403)4.55897620
2Abnormality of T cell number (HP:0011839)4.38543781
3Thyroiditis (HP:0100646)4.03679179
4Severe combined immunodeficiency (HP:0004430)3.90444734
5Eosinophilia (HP:0001880)3.88232937
6Combined immunodeficiency (HP:0005387)3.60587718
7Recurrent viral infections (HP:0004429)3.55818270
8Abnormality of the fingertips (HP:0001211)3.50315343
9Abnormality of eosinophils (HP:0001879)3.34749064
10Hypoplasia of the thymus (HP:0000778)3.33529807
11Deep venous thrombosis (HP:0002625)3.31645792
12Panhypogammaglobulinemia (HP:0003139)3.29312612
13Abnormality of B cell number (HP:0010975)3.25547731
14B lymphocytopenia (HP:0010976)3.25547731
15Recurrent fungal infections (HP:0002841)3.23171679
16Granulocytopenia (HP:0001913)3.09330185
17Thick nail (HP:0001805)3.07845309
18Myocardial infarction (HP:0001658)3.07787509
19Colitis (HP:0002583)2.91475092
20Autoimmune thrombocytopenia (HP:0001973)2.85135149
21Nephritis (HP:0000123)2.80989861
22Leukocytosis (HP:0001974)2.80282294
23Complement deficiency (HP:0004431)2.79954363
24Hemorrhage of the eye (HP:0011885)2.79067064
25Hypobetalipoproteinemia (HP:0003563)2.76929422
26Premature skin wrinkling (HP:0100678)2.75470647
27Agammaglobulinemia (HP:0004432)2.69557222
28Gastrointestinal stroma tumor (HP:0100723)2.69396478
29Papillary thyroid carcinoma (HP:0002895)2.69068984
30Eczematoid dermatitis (HP:0000976)2.65790336
31Menorrhagia (HP:0000132)2.62007292
32Aortic aneurysm (HP:0004942)2.59252205
33Chronic otitis media (HP:0000389)2.57803214
34Viral hepatitis (HP:0006562)2.57242903
35Mitral stenosis (HP:0001718)2.56208460
36Abnormality of T cells (HP:0002843)2.55679363
37Papilloma (HP:0012740)2.53436659
38Verrucae (HP:0200043)2.53436659
39Chronic diarrhea (HP:0002028)2.51517159
40Inflammation of the large intestine (HP:0002037)2.51417258
41Gingival bleeding (HP:0000225)2.50519943
42Abnormality of the vasculature of the conjunctiva (HP:0008054)2.50147680
43Hyperlipoproteinemia (HP:0010980)2.49546274
44Small epiphyses (HP:0010585)2.49512182
45Conjunctival telangiectasia (HP:0000524)2.48750102
46Spontaneous hematomas (HP:0007420)2.45429506
47Joint hemorrhage (HP:0005261)2.44280059
48Autoimmune hemolytic anemia (HP:0001890)2.41892428
49Xanthomatosis (HP:0000991)2.38846261
50IgM deficiency (HP:0002850)2.36703553
51Gingivitis (HP:0000230)2.35739843
52Abnormality of monocarboxylic acid metabolism (HP:0010996)2.34871733
53Mediastinal lymphadenopathy (HP:0100721)2.33156157
54Spontaneous abortion (HP:0005268)2.32288447
55Scanning speech (HP:0002168)2.32105099
56Vasculitis (HP:0002633)2.31767602
57Stomatitis (HP:0010280)2.30941152
58Subacute progressive viral hepatitis (HP:0006572)2.30580840
59Hematochezia (HP:0002573)2.29208448
60Systemic lupus erythematosus (HP:0002725)2.28630818
61Gastrointestinal inflammation (HP:0004386)2.27159780
62Pustule (HP:0200039)2.26385438
63Prolonged partial thromboplastin time (HP:0003645)2.25213921
64Meningitis (HP:0001287)2.24456103
65Recurrent cutaneous fungal infections (HP:0011370)2.22460372
66Chronic mucocutaneous candidiasis (HP:0002728)2.22460372
67Recurrent skin infections (HP:0001581)2.20830249
68IgA deficiency (HP:0002720)2.20460152
69Lymphopenia (HP:0001888)2.20021296
70Elevated erythrocyte sedimentation rate (HP:0003565)2.18619910
71Arterial tortuosity (HP:0005116)2.18497809
72Recurrent gram-negative bacterial infections (HP:0005420)2.16735472
73Recurrent bronchitis (HP:0002837)2.16685767
74Pulmonary embolism (HP:0002204)2.16678686
75Intrahepatic cholestasis (HP:0001406)2.16233765
76Submucous cleft hard palate (HP:0000176)2.14058094
77Cerebral aneurysm (HP:0004944)2.13051334
78Abnormal delayed hypersensitivity skin test (HP:0002963)2.12431970
79Thrombophlebitis (HP:0004418)2.12201421
80Flat acetabular roof (HP:0003180)2.12079340
81Esophageal varix (HP:0002040)2.11785436
82IgG deficiency (HP:0004315)2.11217914
83Recurrent bacterial skin infections (HP:0005406)2.09979877
84Epiphyseal dysplasia (HP:0002656)2.09895510
85Acanthocytosis (HP:0001927)2.08530729
86Depressed nasal tip (HP:0000437)2.05713245
87Retrobulbar optic neuritis (HP:0100654)2.04481130
88Optic neuritis (HP:0100653)2.04481130
89Abnormality of cells of the lymphoid lineage (HP:0012140)2.03095250
90Fair hair (HP:0002286)2.02492264
91Cellulitis (HP:0100658)2.02297116
92Acute myeloid leukemia (HP:0004808)2.01510974
93Recurrent abscess formation (HP:0002722)2.00267035
94Narrow palate (HP:0000189)1.97653569
95Abnormality of the common coagulation pathway (HP:0010990)1.96017597
96Hypoalphalipoproteinemia (HP:0003233)1.94460186
97Emphysema (HP:0002097)1.92391097
98Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.91672427
99Abnormal platelet function (HP:0011869)1.91448764
100Impaired platelet aggregation (HP:0003540)1.91448764
101Vascular tortuosity (HP:0004948)1.91390883
102Orchitis (HP:0100796)1.91074466
103Abnormality of complement system (HP:0005339)1.90755282
104Abnormal platelet volume (HP:0011876)1.89475534
105Glomerulonephritis (HP:0000099)1.89254527
106Abnormality of the peritoneum (HP:0002585)1.89131164
107Myositis (HP:0100614)1.86520973
108Hepatitis (HP:0012115)1.85961569
109Conjugated hyperbilirubinemia (HP:0002908)1.85719291
110Purpura (HP:0000979)1.84742883
111Disproportionate tall stature (HP:0001519)1.84548160
112Pulmonary infiltrates (HP:0002113)1.82895567
113Hypolipoproteinemia (HP:0010981)1.82823157
114Dysmetric saccades (HP:0000641)1.81547744
115Osteomyelitis (HP:0002754)1.80082904
116Abnormality of glutamine family amino acid metabolism (HP:0010902)1.79445568
117Prolonged bleeding time (HP:0003010)1.77815597
118Epidermoid cyst (HP:0200040)1.77602948
119Aortic dissection (HP:0002647)1.77585582
120Recurrent sinusitis (HP:0011108)1.76903403
121Arterial thrombosis (HP:0004420)1.76782021
122Abnormality of secondary sexual hair (HP:0009888)1.76766482
123Abnormality of the axillary hair (HP:0100134)1.76766482
124Periodontitis (HP:0000704)1.76093743
125Renal cortical cysts (HP:0000803)1.74660244
126Osteolytic defects of the phalanges of the hand (HP:0009771)1.74185959
127Osteolytic defects of the hand bones (HP:0009699)1.74185959
128Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.73823902
129Abnormality of the level of lipoprotein cholesterol (HP:0010979)1.73592189
130Coarse hair (HP:0002208)1.72650495
131Dislocated radial head (HP:0003083)1.72511320
132Spondylolisthesis (HP:0003302)1.72156156
133Epistaxis (HP:0000421)1.69656461
134Increased mean platelet volume (HP:0011877)1.69437021
135Asymmetry of the thorax (HP:0001555)1.69325828
136Hydroxyprolinuria (HP:0003080)1.69238045
137Abnormality of proline metabolism (HP:0010907)1.69238045
138Hyperglycinuria (HP:0003108)1.69228160
139Hypercholesterolemia (HP:0003124)1.68932328
140Increased IgE level (HP:0003212)1.68469768
141Vascular calcification (HP:0004934)1.68262214
142Cardiovascular calcification (HP:0011915)1.68021936
143Abnormal foot bone ossification (HP:0010675)1.67740462
144Gastrointestinal infarctions (HP:0005244)1.66951445
145Abnormal glucose tolerance (HP:0001952)1.66394886

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K13.29022514
2TXK3.11567417
3BLK2.89947207
4SIK12.59021649
5EPHB12.38869370
6FGFR42.38694128
7TYK22.15416904
8JAK12.15148182
9ITK1.99477343
10TGFBR21.99148642
11TAOK31.97080961
12JAK31.96570460
13STK101.96377616
14AKT31.94332411
15IKBKE1.88370045
16FGFR31.84996395
17NLK1.80900905
18TNIK1.80338587
19IRAK41.77962203
20CSK1.77353190
21MAP3K141.76240009
22FGFR21.76190631
23TYRO31.72198155
24PDGFRB1.64684739
25FES1.60021886
26SGK21.57881427
27PKN21.50811318
28CDC42BPA1.47488175
29CAMK1D1.46964080
30PIK3CG1.45349908
31PRPF4B1.44460118
32CSF1R1.44395740
33LATS11.38120992
34TBK11.37043629
35CAMK1G1.35573616
36PRKCQ1.33769233
37ZAP701.28819332
38MAP3K101.27635082
39LCK1.27413031
40NUAK11.24137326
41HCK1.22144948
42WNK11.19428725
43MAP3K131.19259821
44IRAK31.17082517
45IRAK11.15463392
46PKN11.15004834
47BRD41.14766166
48MST41.13563547
49GRK61.12334947
50ACVR1B1.10674354
51ERN11.10650302
52IKBKB1.10634718
53MAP2K31.08836679
54MAP3K21.07487108
55EEF2K1.06046395
56MAPK71.04568438
57JAK21.03963493
58PTK61.03949114
59BTK1.00016970
60MAP3K70.97590131
61TRIB30.97565274
62CDK90.96291164
63STK240.95273246
64RIPK10.94190688
65SYK0.93647818
66IRAK20.91876583
67STK390.91105732
68CLK10.91089718
69MARK30.90203756
70INSRR0.85998624
71FRK0.85692894
72SGK4940.85348043
73SGK2230.85348043
74MAPK120.85140875
75TEC0.83862076
76SCYL20.83128602
77PRKAA20.82839941
78LRRK20.82226707
79CDK120.82181856
80CHUK0.81252743
81PRKCH0.79659272
82MAP3K60.79424562
83DMPK0.78970850
84MELK0.78479776
85LYN0.77385578
86STK40.74254288
87BMPR20.73468034
88SGK10.72862961
89MTOR0.72135803
90KIT0.72049014
91SIK20.69571830
92CDK40.69479884
93STK30.67884174
94RIPK40.66619620
95EIF2AK30.66351078
96EPHA30.66220861
97INSR0.64677469
98SGK30.63637724
99MAP3K10.61211221
100PDK10.61013998
101ICK0.60383762
102NEK90.58153143
103PIK3CA0.57946513
104MARK20.57871947
105FER0.57630964
106TTN0.57007186
107IGF1R0.56797639
108PIM10.56397155
109MAPK110.56129890
110NEK60.55683426
111PRKD20.55477590
112ERBB20.54944751
113FGR0.54713258
114PRKD10.54607313
115TRPM70.53758226
116RET0.53667549
117RPS6KB20.52501283
118CDK60.51875841
119PDGFRA0.51707718
120MATK0.49551624
121ABL10.49106208
122FYN0.46395865
123FGFR10.45304046
124MAPK150.45258354
125SMG10.44365310
126EGFR0.44245148
127PDPK10.42335193
128DDR20.41474164
129HIPK20.40566457
130CAMK40.39801070
131TIE10.39249226
132YES10.38963928
133RPS6KB10.37973779

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053403.35786589
2Staphylococcus aureus infection_Homo sapiens_hsa051502.28407175
3Fatty acid degradation_Homo sapiens_hsa000712.25610883
4T cell receptor signaling pathway_Homo sapiens_hsa046602.07142919
5Fatty acid metabolism_Homo sapiens_hsa012122.02326121
6Primary bile acid biosynthesis_Homo sapiens_hsa001201.93607221
7B cell receptor signaling pathway_Homo sapiens_hsa046621.87783813
8NF-kappa B signaling pathway_Homo sapiens_hsa040641.73332831
9PPAR signaling pathway_Homo sapiens_hsa033201.72233360
10Complement and coagulation cascades_Homo sapiens_hsa046101.70489775
11Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.68981801
12Osteoclast differentiation_Homo sapiens_hsa043801.66956545
13Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.65133945
14Intestinal immune network for IgA production_Homo sapiens_hsa046721.64554608
15Propanoate metabolism_Homo sapiens_hsa006401.63365566
16Lysine degradation_Homo sapiens_hsa003101.63227845
17Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.55851796
18Systemic lupus erythematosus_Homo sapiens_hsa053221.52802104
19Fatty acid biosynthesis_Homo sapiens_hsa000611.52326918
20Nitrogen metabolism_Homo sapiens_hsa009101.45589447
21Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.45361121
22Measles_Homo sapiens_hsa051621.44917992
23Hematopoietic cell lineage_Homo sapiens_hsa046401.43119280
24Steroid biosynthesis_Homo sapiens_hsa001001.39193450
25Tryptophan metabolism_Homo sapiens_hsa003801.37306601
26Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.31560927
27ABC transporters_Homo sapiens_hsa020101.21235706
28Viral myocarditis_Homo sapiens_hsa054161.21049897
29Peroxisome_Homo sapiens_hsa041461.15591742
30Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.15257768
31Fatty acid elongation_Homo sapiens_hsa000621.14113602
32Toxoplasmosis_Homo sapiens_hsa051451.11924171
33Other glycan degradation_Homo sapiens_hsa005111.11440876
34Insulin resistance_Homo sapiens_hsa049311.11378130
35Leukocyte transendothelial migration_Homo sapiens_hsa046701.10385326
36Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.10128522
37Leishmaniasis_Homo sapiens_hsa051401.09910241
38Adipocytokine signaling pathway_Homo sapiens_hsa049201.06568179
39Jak-STAT signaling pathway_Homo sapiens_hsa046301.04640147
40Pertussis_Homo sapiens_hsa051331.04151879
41* Phosphatidylinositol signaling system_Homo sapiens_hsa040701.00721730
42Arginine biosynthesis_Homo sapiens_hsa002201.00647609
43Pancreatic cancer_Homo sapiens_hsa052121.00569178
44Inositol phosphate metabolism_Homo sapiens_hsa005620.99201356
45Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.99165930
46Dorso-ventral axis formation_Homo sapiens_hsa043200.97627439
47Prolactin signaling pathway_Homo sapiens_hsa049170.97173292
48Toll-like receptor signaling pathway_Homo sapiens_hsa046200.96051936
49Acute myeloid leukemia_Homo sapiens_hsa052210.93627700
50Malaria_Homo sapiens_hsa051440.91663720
51Chronic myeloid leukemia_Homo sapiens_hsa052200.90833675
52Asthma_Homo sapiens_hsa053100.90178460
53Prion diseases_Homo sapiens_hsa050200.87899029
54beta-Alanine metabolism_Homo sapiens_hsa004100.87773225
55Butanoate metabolism_Homo sapiens_hsa006500.87628886
56Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.87162566
57Chemokine signaling pathway_Homo sapiens_hsa040620.84708603
58Glycerolipid metabolism_Homo sapiens_hsa005610.82833660
59Caffeine metabolism_Homo sapiens_hsa002320.82710775
60Pentose and glucuronate interconversions_Homo sapiens_hsa000400.81555589
61Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.80909429
62Glioma_Homo sapiens_hsa052140.77172206
63Hepatitis C_Homo sapiens_hsa051600.76368220
64Renin-angiotensin system_Homo sapiens_hsa046140.76223780
65HIF-1 signaling pathway_Homo sapiens_hsa040660.75825571
66Endometrial cancer_Homo sapiens_hsa052130.75795339
67* Platelet activation_Homo sapiens_hsa046110.74829322
68Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.74727271
69Carbohydrate digestion and absorption_Homo sapiens_hsa049730.74375408
70mTOR signaling pathway_Homo sapiens_hsa041500.73857756
71Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.73675376
72Thyroid hormone signaling pathway_Homo sapiens_hsa049190.72576449
73TNF signaling pathway_Homo sapiens_hsa046680.70589349
74Allograft rejection_Homo sapiens_hsa053300.70157685
75Notch signaling pathway_Homo sapiens_hsa043300.70106518
76Prostate cancer_Homo sapiens_hsa052150.69096973
77AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.68657319
78RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.68618343
79Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.68045769
80Amoebiasis_Homo sapiens_hsa051460.67429719
81Viral carcinogenesis_Homo sapiens_hsa052030.67249830
82Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.66857620
83Choline metabolism in cancer_Homo sapiens_hsa052310.66190907
84Steroid hormone biosynthesis_Homo sapiens_hsa001400.65813917
85Small cell lung cancer_Homo sapiens_hsa052220.65633759
86NOD-like receptor signaling pathway_Homo sapiens_hsa046210.65017252
87Adherens junction_Homo sapiens_hsa045200.64584414
88ECM-receptor interaction_Homo sapiens_hsa045120.64546750
89Type I diabetes mellitus_Homo sapiens_hsa049400.63687574
90Histidine metabolism_Homo sapiens_hsa003400.63315182
91Influenza A_Homo sapiens_hsa051640.62862063
92Colorectal cancer_Homo sapiens_hsa052100.62500477
93Fat digestion and absorption_Homo sapiens_hsa049750.62390827
94Focal adhesion_Homo sapiens_hsa045100.61967303
95Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.61036293
96Bile secretion_Homo sapiens_hsa049760.59970312
97MicroRNAs in cancer_Homo sapiens_hsa052060.59130487
98Neurotrophin signaling pathway_Homo sapiens_hsa047220.58559970
99Hepatitis B_Homo sapiens_hsa051610.58515214
100Antigen processing and presentation_Homo sapiens_hsa046120.57478393
101Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.57295795
102Phospholipase D signaling pathway_Homo sapiens_hsa040720.57208973
103Lysosome_Homo sapiens_hsa041420.56910720
104Sphingolipid signaling pathway_Homo sapiens_hsa040710.56744054
105Ether lipid metabolism_Homo sapiens_hsa005650.55593059
106VEGF signaling pathway_Homo sapiens_hsa043700.55105328
107Retinol metabolism_Homo sapiens_hsa008300.54568725
108Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.54161643
109Renal cell carcinoma_Homo sapiens_hsa052110.53915086
110Sulfur metabolism_Homo sapiens_hsa009200.52995970
111Legionellosis_Homo sapiens_hsa051340.50750246
112* Apoptosis_Homo sapiens_hsa042100.50381085
113Autoimmune thyroid disease_Homo sapiens_hsa053200.49010809
114FoxO signaling pathway_Homo sapiens_hsa040680.48983046
115Herpes simplex infection_Homo sapiens_hsa051680.48314809
116Non-small cell lung cancer_Homo sapiens_hsa052230.47998567
117Graft-versus-host disease_Homo sapiens_hsa053320.47716811
118Starch and sucrose metabolism_Homo sapiens_hsa005000.46498287
119Non-homologous end-joining_Homo sapiens_hsa034500.46090213
120Transcriptional misregulation in cancer_Homo sapiens_hsa052020.45947193
121Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.45660467
122Glycosaminoglycan degradation_Homo sapiens_hsa005310.42223103
123Chemical carcinogenesis_Homo sapiens_hsa052040.42176794
124Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.41523469
125Tuberculosis_Homo sapiens_hsa051520.39998877
126Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.39519897

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