ITPR3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a receptor for inositol 1,4,5-trisphosphate, a second messenger that mediates the release of intracellular calcium. The receptor contains a calcium channel at the C-terminus and the ligand-binding site at the N-terminus. Knockout studies in mice suggest that type 2 and type 3 inositol 1,4,5-trisphosphate receptors play a key role in exocrine secretion underlying energy metabolism and growth. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1hemidesmosome assembly (GO:0031581)6.42508904
2desmosome organization (GO:0002934)4.47840263
3antigen processing and presentation of endogenous antigen (GO:0019883)3.81328393
4antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.71979028
5antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.71979028
6cell-substrate junction assembly (GO:0007044)3.71571891
7surfactant homeostasis (GO:0043129)3.59493345
8semaphorin-plexin signaling pathway (GO:0071526)3.56470010
9maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.50019181
10positive regulation of histone deacetylation (GO:0031065)3.48964688
11positive thymic T cell selection (GO:0045059)3.41910353
12endothelial cell chemotaxis (GO:0035767)3.37167629
13retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.32567862
14regulation of gamma-delta T cell differentiation (GO:0045586)3.31598131
15positive regulation of gamma-delta T cell activation (GO:0046645)3.30489946
16regulation of water loss via skin (GO:0033561)3.28908453
17skin morphogenesis (GO:0043589)3.26831772
18protein retention in ER lumen (GO:0006621)3.24513049
19branching involved in mammary gland duct morphogenesis (GO:0060444)3.22676036
20regulation of cholesterol homeostasis (GO:2000188)3.22406305
21heterochromatin organization (GO:0070828)3.11121410
22epithelial cell-cell adhesion (GO:0090136)3.09663431
23regulation of glucose import in response to insulin stimulus (GO:2001273)3.05378297
24regulation of histone H3-K27 methylation (GO:0061085)3.04680783
25hepatocyte apoptotic process (GO:0097284)3.03133409
26protein localization to endosome (GO:0036010)3.01870202
27cytoskeletal anchoring at plasma membrane (GO:0007016)2.99934266
28dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.99625434
29regulation of gamma-delta T cell activation (GO:0046643)2.98824184
30trophectodermal cell differentiation (GO:0001829)2.97485378
31basement membrane organization (GO:0071711)2.94346989
32response to laminar fluid shear stress (GO:0034616)2.88470428
33cellular response to epidermal growth factor stimulus (GO:0071364)2.88151264
34glomerular visceral epithelial cell development (GO:0072015)2.85039592
35thymic T cell selection (GO:0045061)2.84593518
36negative regulation of cell size (GO:0045792)2.84220209
37establishment of skin barrier (GO:0061436)2.82958933
38cell adhesion mediated by integrin (GO:0033627)2.81988151
39planar cell polarity pathway involved in neural tube closure (GO:0090179)2.81315026
40bundle of His cell to Purkinje myocyte communication (GO:0086069)2.80444814
41interferon-gamma secretion (GO:0072643)2.80043134
42cytoplasmic mRNA processing body assembly (GO:0033962)2.79962457
43positive regulation of keratinocyte differentiation (GO:0045618)2.74761939
44negative regulation of anoikis (GO:2000811)2.74197208
45mammary gland epithelial cell proliferation (GO:0033598)2.73319073
46positive regulation of epidermal cell differentiation (GO:0045606)2.73173984
47negative regulation of viral release from host cell (GO:1902187)2.72311627
48endodermal cell differentiation (GO:0035987)2.70936907
49regulation of translational fidelity (GO:0006450)2.70720355
50COPII vesicle coating (GO:0048208)2.69465908
51regulation of early endosome to late endosome transport (GO:2000641)2.69028957
52atrioventricular valve morphogenesis (GO:0003181)2.68840291
53regulation of hippo signaling (GO:0035330)2.67808711
54proline biosynthetic process (GO:0006561)2.66194955
55intestinal epithelial cell development (GO:0060576)2.65941783
56positive regulation of establishment of protein localization to plasma membrane (GO:0090004)2.65757402
57regulation of anoikis (GO:2000209)2.62715480
58regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.62609614
59epithelial cell differentiation involved in prostate gland development (GO:0060742)2.62115305
60germ cell migration (GO:0008354)2.61910439
61keratinocyte differentiation (GO:0030216)2.61507231
62regulation of interleukin-12 biosynthetic process (GO:0045075)2.61197261
63nuclear pore complex assembly (GO:0051292)2.60889700
64endothelial cell morphogenesis (GO:0001886)2.60481700
65mitotic chromosome condensation (GO:0007076)2.59120529
66negative regulation of stress fiber assembly (GO:0051497)2.58503100
67apoptotic process involved in morphogenesis (GO:0060561)2.56750247
68B cell receptor signaling pathway (GO:0050853)2.56733444
69chemical homeostasis within a tissue (GO:0048875)2.55066984
70endoplasmic reticulum unfolded protein response (GO:0030968)2.53659090
71regulation of endothelial cell chemotaxis (GO:2001026)2.53579749
72membrane protein ectodomain proteolysis (GO:0006509)2.53379529
73negative regulation of keratinocyte proliferation (GO:0010839)2.52325487
74positive regulation of protein deacetylation (GO:0090312)2.52110032
75protein localization to microtubule (GO:0035372)2.51658543
76positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003602.51619014
77gap junction assembly (GO:0016264)2.49979202
78mesodermal cell differentiation (GO:0048333)2.48344664
79negative regulation of epidermal growth factor-activated receptor activity (GO:0007175)2.48060993
80regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)2.47719649
81positive regulation of protein localization to plasma membrane (GO:1903078)2.47182391
82regulation of mammary gland epithelial cell proliferation (GO:0033599)2.47135190
83renal filtration (GO:0097205)2.46861648
84vesicle coating (GO:0006901)2.46283790
85morphogenesis of an endothelium (GO:0003159)2.45397287
86endothelial tube morphogenesis (GO:0061154)2.45397287
87response to epidermal growth factor (GO:0070849)2.44926213
88positive T cell selection (GO:0043368)2.44242130
89vascular endothelial growth factor signaling pathway (GO:0038084)2.44188492
90COPI coating of Golgi vesicle (GO:0048205)2.43935464
91Golgi transport vesicle coating (GO:0048200)2.43935464
92ER-nucleus signaling pathway (GO:0006984)2.43895114
93actin filament depolymerization (GO:0030042)2.43399048
94stress fiber assembly (GO:0043149)2.42388934
95actin filament bundle assembly (GO:0051017)2.42339844
96actin filament bundle organization (GO:0061572)2.42339844
97glomerular epithelial cell development (GO:0072310)2.41990268
98T cell selection (GO:0045058)2.39830952
99negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.39768842
100membrane raft organization (GO:0031579)2.39514177
101insulin-like growth factor receptor signaling pathway (GO:0048009)2.38310235
102cell junction assembly (GO:0034329)2.37598665
103barbed-end actin filament capping (GO:0051016)2.36660796
104glucocorticoid receptor signaling pathway (GO:0042921)2.36453773
105maternal placenta development (GO:0001893)2.35533305
106endocytic recycling (GO:0032456)2.35410228
107embryonic process involved in female pregnancy (GO:0060136)2.35231997
108embryonic eye morphogenesis (GO:0048048)2.34442733
109regulation of transforming growth factor beta1 production (GO:0032908)2.33598930
110negative regulation of chondrocyte differentiation (GO:0032331)2.33243721
111cellular response to unfolded protein (GO:0034620)2.33173519
112adherens junction assembly (GO:0034333)2.33085489
113mitotic G1 DNA damage checkpoint (GO:0031571)2.30370280
114activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.29922778
115positive regulation of blood vessel endothelial cell migration (GO:0043536)2.29859625
116regulation of viral release from host cell (GO:1902186)2.29582586
117establishment of endothelial barrier (GO:0061028)2.29454255
118negative regulation of histone methylation (GO:0031061)2.29312246
119response to UV-C (GO:0010225)2.27639117
120keratinization (GO:0031424)2.26177204
121keratinocyte proliferation (GO:0043616)2.25301583
122viral transcription (GO:0019083)2.24950309
123positive regulation of nuclease activity (GO:0032075)2.23896296
124regulation of T cell tolerance induction (GO:0002664)2.23741356
125apoptotic cell clearance (GO:0043277)2.22717300
126hypotonic response (GO:0006971)2.22644254
127nuclear pore organization (GO:0006999)2.22239024
128regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.21694470
129positive regulation of p38MAPK cascade (GO:1900745)2.19989749
130epidermal cell differentiation (GO:0009913)2.19293939
131positive regulation of endothelial cell apoptotic process (GO:2000353)2.19146832
132multicellular organismal water homeostasis (GO:0050891)2.18883274
133positive regulation of SMAD protein import into nucleus (GO:0060391)2.18838116
134activation of Rac GTPase activity (GO:0032863)2.18833108
135protein heterotrimerization (GO:0070208)2.18357079
136regulation of integrin activation (GO:0033623)2.17594787
137response to fluid shear stress (GO:0034405)2.17410502
138negative regulation of interleukin-8 production (GO:0032717)2.13575389
139cell migration involved in sprouting angiogenesis (GO:0002042)2.13277511
140regulation of extracellular matrix disassembly (GO:0010715)2.12626252
141NLS-bearing protein import into nucleus (GO:0006607)2.12519530
142cortical actin cytoskeleton organization (GO:0030866)2.12464205
143positive regulation of Cdc42 GTPase activity (GO:0043089)2.11491849
144translational termination (GO:0006415)2.11491654
145mRNA stabilization (GO:0048255)2.11339175
146RNA stabilization (GO:0043489)2.11339175
147regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.10774182
148regulation of SMAD protein import into nucleus (GO:0060390)2.10173073
149regulation of nuclease activity (GO:0032069)2.10052924
150negative regulation of bone resorption (GO:0045779)2.09786912
151JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.09164453
152wound healing, spreading of epidermal cells (GO:0035313)2.08314760
153negative regulation of fatty acid transport (GO:2000192)2.06775280
154receptor catabolic process (GO:0032801)2.06500803
155mRNA transcription (GO:0009299)2.05537386
156gland morphogenesis (GO:0022612)2.05197478
157negative regulation of erythrocyte differentiation (GO:0045647)2.05122498
158regulation of tight junction assembly (GO:2000810)2.05109200
159cell-substrate adherens junction assembly (GO:0007045)2.04964643
160focal adhesion assembly (GO:0048041)2.04964643
161hippo signaling (GO:0035329)2.04704594
162positive regulation of cell adhesion mediated by integrin (GO:0033630)2.04435789
163epithelial structure maintenance (GO:0010669)2.04293741

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human7.56738855
2NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.67532225
3EGR1_19374776_ChIP-ChIP_THP-1_Human3.27119317
4MYC_22102868_ChIP-Seq_BL_Human3.09507538
5E2F7_22180533_ChIP-Seq_HELA_Human2.78255941
6FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.59244892
7TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.44027733
8FOXM1_23109430_ChIP-Seq_U2OS_Human2.36142745
9STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.31646821
10VDR_21846776_ChIP-Seq_THP-1_Human2.27879177
11TCF7_22412390_ChIP-Seq_EML_Mouse2.06810158
12KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human2.05989910
13* ELK3_25401928_ChIP-Seq_HUVEC_Human2.03798833
14SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.01449911
15RARG_19884340_ChIP-ChIP_MEFs_Mouse1.99386402
16IRF8_22096565_ChIP-ChIP_GC-B_Human1.98922732
17STAT6_21828071_ChIP-Seq_BEAS2B_Human1.97143868
18ZNF263_19887448_ChIP-Seq_K562_Human1.96058376
19KDM2B_26808549_Chip-Seq_DND41_Human1.88952584
20KDM2B_26808549_Chip-Seq_SUP-B15_Human1.86648573
21* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.81772133
22KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.78886584
23FOXO3_23340844_ChIP-Seq_DLD1_Human1.73084310
24UTX_26944678_Chip-Seq_JUKART_Human1.70255056
25MAF_26560356_Chip-Seq_TH1_Human1.70234043
26HIF1A_21447827_ChIP-Seq_MCF-7_Human1.69931008
27KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.67330292
28ATF3_27146783_Chip-Seq_COLON_Human1.67228723
29SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.66513706
30SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.66513706
31ESR1_21235772_ChIP-Seq_MCF-7_Human1.66431854
32CLOCK_20551151_ChIP-Seq_293T_Human1.64888946
33RACK7_27058665_Chip-Seq_MCF-7_Human1.64231945
34TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.59939030
35TRIM28_21343339_ChIP-Seq_HEK293_Human1.58519969
36RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.57207903
37STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.56832598
38* EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.56829952
39DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.56811344
40THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.55213689
41FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.54484192
42ESR2_21235772_ChIP-Seq_MCF-7_Human1.53284976
43* SOX9_24532713_ChIP-Seq_HFSC_Mouse1.52719245
44ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.50187607
45STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.49755434
46GATA6_25053715_ChIP-Seq_YYC3_Human1.48149151
47RUNX1_27514584_Chip-Seq_MCF-7_Human1.47144240
48VDR_24763502_ChIP-Seq_THP-1_Human1.45754123
49TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.44379802
50FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.43333488
51* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.43158810
52SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.41264477
53MYB_26560356_Chip-Seq_TH2_Human1.40906325
54RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.40382004
55SOX2_27498859_Chip-Seq_STOMACH_Mouse1.40105113
56TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.39908213
57MYB_26560356_Chip-Seq_TH1_Human1.38251619
58* BRD4_27068464_Chip-Seq_AML-cells_Mouse1.38121065
59P300_27058665_Chip-Seq_ZR-75-30cells_Human1.37809301
60ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.35787789
61RUNX_20019798_ChIP-Seq_JUKART_Human1.35361187
62P63_26484246_Chip-Seq_KERATINOCYTES_Human1.35099760
63* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.31639239
64LXR_22292898_ChIP-Seq_THP-1_Human1.30956338
65PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.28822469
66NCOR1_26117541_ChIP-Seq_K562_Human1.28231676
67PPAR_26484153_Chip-Seq_NCI-H1993_Human1.27728193
68* KLF4_18555785_ChIP-Seq_MESCs_Mouse1.26013775
69MYB_21317192_ChIP-Seq_ERMYB_Mouse1.23443372
70MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.23369512
71NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.22012410
72HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.21995294
73KDM2B_26808549_Chip-Seq_JURKAT_Human1.21501336
74UBF1/2_26484160_Chip-Seq_HMECs_Human1.18866783
75ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.18744032
76CDX2_20551321_ChIP-Seq_CACO-2_Human1.18742174
77FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.18706637
78ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.16949959
79KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.16563652
80TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.16034452
81TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.15655111
82SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.15542880
83RUNX1_22412390_ChIP-Seq_EML_Mouse1.13141735
84CREB1_26743006_Chip-Seq_LNCaP_Human1.12146946
85SMC4_20622854_ChIP-Seq_HELA_Human1.11697179
86CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.10822119
87FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.09738950
88NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.06886936
89CTCF_27219007_Chip-Seq_ERYTHROID_Human1.06437779
90KLF5_25053715_ChIP-Seq_YYC3_Human1.06290312
91PPARA_22158963_ChIP-Seq_LIVER_Mouse1.05271191
92EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.05187020
93CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.05045535
94* TET1_21451524_ChIP-Seq_MESCs_Mouse1.04121742
95ZFP281_18757296_ChIP-ChIP_E14_Mouse1.02946111
96UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.02867086
97ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.02611322
98* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.02346779
99P68_20966046_ChIP-Seq_HELA_Human1.01631930
100* ZFP281_27345836_Chip-Seq_ESCs_Mouse1.00838275
101* SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.00718676
102SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.00433839
103JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.00173529
104MAF_26560356_Chip-Seq_TH2_Human1.00056786
105CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.99100859
106GATA4_25053715_ChIP-Seq_YYC3_Human0.98784937
107CHD1_26751641_Chip-Seq_LNCaP_Human0.98635637
108TP53_22127205_ChIP-Seq_IMR90_Human0.98403900
109* NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.98301740
110TBX20_22080862_ChIP-Seq_HEART_Mouse0.98228553
111TBX20_22328084_ChIP-Seq_HEART_Mouse0.98228553
112MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse0.96812896
113NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.96565787
114SPI1_23127762_ChIP-Seq_K562_Human0.96531753
115* TP63_22573176_ChIP-Seq_HFKS_Human0.94464092
116STAT3_1855785_ChIP-Seq_MESCs_Mouse0.93408821
117* TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.93210532
118IRF8_27001747_Chip-Seq_BMDM_Mouse0.93073566
119PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.92995622
120DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.92830148
121ZFX_18555785_ChIP-Seq_MESCs_Mouse0.92301650
122FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human0.91901384
123SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.90720219
124TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.90445797
125IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.90270470
126* KDM2B_26808549_Chip-Seq_K562_Human0.90164318
127AR_21909140_ChIP-Seq_LNCAP_Human0.89741727
128IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.88306884
129CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.87851040
130SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.87311694
131* GATA2_21666600_ChIP-Seq_HMVEC_Human0.86384428
132* BRD4_25478319_ChIP-Seq_HGPS_Human0.85802368
133EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.84659094

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010234_abnormal_vibrissa_follicle3.89102473
2MP0003705_abnormal_hypodermis_morpholog3.52143027
3MP0010352_gastrointestinal_tract_polyps3.22048453
4MP0005275_abnormal_skin_tensile3.11844671
5MP0003300_gastrointestinal_ulcer2.81423565
6MP0002796_impaired_skin_barrier2.67447125
7MP0003566_abnormal_cell_adhesion2.62771241
8MP0008438_abnormal_cutaneous_collagen2.34965657
9MP0002060_abnormal_skin_morphology2.33138015
10MP0005451_abnormal_body_composition2.27804408
11MP0005076_abnormal_cell_differentiation2.23061817
12MP0005409_darkened_coat_color2.12163079
13MP0005501_abnormal_skin_physiology2.06770985
14MP0004947_skin_inflammation2.05525320
15MP0002877_abnormal_melanocyte_morpholog2.04428753
16MP0003453_abnormal_keratinocyte_physiol2.02579010
17MP0001873_stomach_inflammation1.85155104
18MP0005023_abnormal_wound_healing1.84037915
19MP0004782_abnormal_surfactant_physiolog1.82379530
20MP0009278_abnormal_bone_marrow1.82138771
21MP0006054_spinal_hemorrhage1.74896097
22MP0003045_fibrosis1.72945535
23MP0001849_ear_inflammation1.72133336
24MP0001216_abnormal_epidermal_layer1.67614127
25MP0003091_abnormal_cell_migration1.65256792
26MP0002166_altered_tumor_susceptibility1.60952957
27MP0000566_synostosis1.60946315
28MP0004858_abnormal_nervous_system1.60402552
29MP0003763_abnormal_thymus_physiology1.54005918
30MP0000685_abnormal_immune_system1.52523498
31MP0003191_abnormal_cellular_cholesterol1.50911311
32MP0004272_abnormal_basement_membrane1.49402293
33MP0001790_abnormal_immune_system1.47962276
34MP0005387_immune_system_phenotype1.47962276
35MP0010678_abnormal_skin_adnexa1.46724948
36MP0002254_reproductive_system_inflammat1.43818783
37MP0000678_abnormal_parathyroid_gland1.43601061
38MP0001800_abnormal_humoral_immune1.43003428
39MP0001348_abnormal_lacrimal_gland1.42676995
40MP0004264_abnormal_extraembryonic_tissu1.42432210
41MP0003950_abnormal_plasma_membrane1.41369079
42MP0010155_abnormal_intestine_physiology1.38775251
43MP0010771_integument_phenotype1.30472024
44MP0008260_abnormal_autophagy1.29840194
45MP0000733_abnormal_muscle_development1.28735508
46MP0000537_abnormal_urethra_morphology1.27855323
47MP0009840_abnormal_foam_cell1.27643702
48MP0003303_peritoneal_inflammation1.26106204
49MP0004233_abnormal_muscle_weight1.24714633
50MP0004808_abnormal_hematopoietic_stem1.24559444
51MP0003941_abnormal_skin_development1.23716689
52MP0000377_abnormal_hair_follicle1.21758031
53MP0003866_abnormal_defecation1.21518769
54MP0001243_abnormal_dermal_layer1.21381164
55MP0003279_aneurysm1.20347396
56MP0002089_abnormal_postnatal_growth/wei1.18401901
57MP0010307_abnormal_tumor_latency1.17986078
58MP0002098_abnormal_vibrissa_morphology1.17840897
59MP0000490_abnormal_crypts_of1.17438065
60MP0002006_tumorigenesis1.17353639
61MP0000383_abnormal_hair_follicle1.16843565
62MP0010368_abnormal_lymphatic_system1.15968758
63MP0002452_abnormal_antigen_presenting1.14918091
64MP0005623_abnormal_meninges_morphology1.14037158
65MP0009780_abnormal_chondrocyte_physiolo1.13647644
66MP0005360_urolithiasis1.13425619
67MP0004185_abnormal_adipocyte_glucose1.12823486
68MP0005058_abnormal_lysosome_morphology1.10914310
69MP0002396_abnormal_hematopoietic_system1.10096510
70MP0000467_abnormal_esophagus_morphology1.09662799
71MP0009931_abnormal_skin_appearance1.02821110
72MP0005666_abnormal_adipose_tissue1.02519597
73MP0000477_abnormal_intestine_morphology1.01689128
74MP0008961_abnormal_basal_metabolism1.01289840
75MP0001958_emphysema1.00433804
76MP0001835_abnormal_antigen_presentation1.00022714
77MP0000858_altered_metastatic_potential0.99712247
78MP0005375_adipose_tissue_phenotype0.99049714
79MP0002398_abnormal_bone_marrow0.97850953
80MP0000579_abnormal_nail_morphology0.96473533
81MP0001191_abnormal_skin_condition0.95608597
82MP0002420_abnormal_adaptive_immunity0.95432854
83MP0001819_abnormal_immune_cell0.92964011
84MP0000465_gastrointestinal_hemorrhage0.91138904
85MP0009053_abnormal_anal_canal0.90116302
86MP0000350_abnormal_cell_proliferation0.88730220
87MP0001545_abnormal_hematopoietic_system0.88678953
88MP0005397_hematopoietic_system_phenotyp0.88678953
89MP0002234_abnormal_pharynx_morphology0.87753350
90MP0002009_preneoplasia0.87224980
91MP0004197_abnormal_fetal_growth/weight/0.86292967
92MP0003448_altered_tumor_morphology0.85959582
93MP0002723_abnormal_immune_serum0.85915878
94MP0003115_abnormal_respiratory_system0.85603383
95MP0009384_cardiac_valve_regurgitation0.85264898
96MP0005000_abnormal_immune_tolerance0.85163971
97MP0002086_abnormal_extraembryonic_tissu0.85131147
98MP0002405_respiratory_system_inflammati0.84977672
99MP0003436_decreased_susceptibility_to0.83941186
100MP0003283_abnormal_digestive_organ0.83849763
101MP0004957_abnormal_blastocyst_morpholog0.83539965
102MP0008004_abnormal_stomach_pH0.83431011
103MP0009333_abnormal_splenocyte_physiolog0.83312678
104MP0004381_abnormal_hair_follicle0.82414463
105MP0002722_abnormal_immune_system0.82357028
106MP0000003_abnormal_adipose_tissue0.81804195
107MP0002933_joint_inflammation0.81770598
108MP0000716_abnormal_immune_system0.81535707
109MP0005257_abnormal_intraocular_pressure0.80463075
110MP0003984_embryonic_growth_retardation0.80182075
111MP0000703_abnormal_thymus_morphology0.79106785
112MP0000689_abnormal_spleen_morphology0.78270570
113MP0002925_abnormal_cardiovascular_devel0.78180095
114MP0001730_embryonic_growth_arrest0.77910080
115MP0000627_abnormal_mammary_gland0.77150387
116MP0002168_other_aberrant_phenotype0.76089569
117MP0000470_abnormal_stomach_morphology0.76086947
118MP0002896_abnormal_bone_mineralization0.75133347
119MP0005621_abnormal_cell_physiology0.74958876
120MP0002080_prenatal_lethality0.74874517
121MP0006138_congestive_heart_failure0.73908168
122MP0000762_abnormal_tongue_morphology0.73706785
123MP0002088_abnormal_embryonic_growth/wei0.73543311
124MP0005380_embryogenesis_phenotype0.73170327
125MP0001672_abnormal_embryogenesis/_devel0.73170327
126MP0010030_abnormal_orbit_morphology0.73135291
127MP0002019_abnormal_tumor_incidence0.72539763
128MP0001784_abnormal_fluid_regulation0.72498211
129MP0000462_abnormal_digestive_system0.70809127
130MP0000013_abnormal_adipose_tissue0.70121622
131MP0000767_abnormal_smooth_muscle0.69385036
132MP0000751_myopathy0.69121551
133MP0003315_abnormal_perineum_morphology0.68488851
134MP0000367_abnormal_coat/_hair0.64557428
135MP0000534_abnormal_ureter_morphology0.63058748
136MP0001661_extended_life_span0.62565947
137MP0003693_abnormal_embryo_hatching0.62540245
138MP0003111_abnormal_nucleus_morphology0.62289840

Predicted human phenotypes

RankGene SetZ-score
1Atrophic scars (HP:0001075)4.60027593
2Milia (HP:0001056)4.44706609
3Broad face (HP:0000283)4.02302128
4Cerebral aneurysm (HP:0004944)3.50163706
5Protrusio acetabuli (HP:0003179)3.09362343
6Short nail (HP:0001799)3.07694728
7Onycholysis (HP:0001806)3.07458565
8Right ventricular cardiomyopathy (HP:0011663)3.06347943
9Fragile skin (HP:0001030)3.03412790
10Premature rupture of membranes (HP:0001788)2.98335638
11Ankle contracture (HP:0006466)2.88120986
12Plantar hyperkeratosis (HP:0007556)2.82862762
13Fragile nails (HP:0001808)2.78704989
14Natal tooth (HP:0000695)2.74134306
15Ulnar bowing (HP:0003031)2.69698785
16Pustule (HP:0200039)2.65467242
17Advanced eruption of teeth (HP:0006288)2.64054612
18Increased IgE level (HP:0003212)2.61349274
19Increased connective tissue (HP:0009025)2.58733217
20Aortic aneurysm (HP:0004942)2.54874737
21Shallow orbits (HP:0000586)2.52000367
22Abnormality of the distal phalanx of the thumb (HP:0009617)2.49753663
23Alopecia of scalp (HP:0002293)2.48142808
24Vertebral compression fractures (HP:0002953)2.45123188
25Abnormality of nail color (HP:0100643)2.42233721
26Dilatation of the ascending aorta (HP:0005111)2.40480424
27Osteolytic defects of the hand bones (HP:0009699)2.40028694
28Osteolytic defects of the phalanges of the hand (HP:0009771)2.40028694
29Colitis (HP:0002583)2.36778068
30Abnormality of the fingertips (HP:0001211)2.36351150
31Aortic dissection (HP:0002647)2.36109993
32Woolly hair (HP:0002224)2.33417289
33Mitral valve prolapse (HP:0001634)2.27916971
34Ureteral stenosis (HP:0000071)2.27639053
35Cellulitis (HP:0100658)2.27283421
36Abnormality of carpal bone ossification (HP:0006257)2.26547866
37Papilloma (HP:0012740)2.24897168
38Verrucae (HP:0200043)2.24897168
39Agammaglobulinemia (HP:0004432)2.24292897
40Rectal prolapse (HP:0002035)2.24081939
41Achilles tendon contracture (HP:0001771)2.23943586
42Cervical subluxation (HP:0003308)2.22639411
43Abnormal ossification of hand bones (HP:0005921)2.21848258
44Ureteral obstruction (HP:0006000)2.19441081
45Nail dystrophy (HP:0008404)2.19341027
46Inflammation of the large intestine (HP:0002037)2.18876171
47Pili torti (HP:0003777)2.17802197
48Ridged nail (HP:0001807)2.16759001
49Gastrointestinal inflammation (HP:0004386)2.16587008
50Arterial tortuosity (HP:0005116)2.13717547
51Abnormality of the gastric mucosa (HP:0004295)2.13162586
52Emphysema (HP:0002097)2.10622861
53Hematochezia (HP:0002573)2.10382776
54Increased density of long bones (HP:0006392)2.06958531
55Abnormality of the Achilles tendon (HP:0005109)2.05896424
56Abnormality of the distal phalanges of the toes (HP:0010182)2.05303583
57Recurrent bronchitis (HP:0002837)2.05248774
58Genu recurvatum (HP:0002816)2.03429310
59Thin bony cortex (HP:0002753)2.02188420
60Trismus (HP:0000211)2.01498009
61Lip pit (HP:0100267)2.01150811
62Lower limb amyotrophy (HP:0007210)1.97214647
63Interstitial pulmonary disease (HP:0006530)1.96973073
64Hemorrhage of the eye (HP:0011885)1.96135383
65Aneurysm (HP:0002617)1.95533796
66Wormian bones (HP:0002645)1.94938663
67Focal segmental glomerulosclerosis (HP:0000097)1.94407671
68Spinal cord compression (HP:0002176)1.92180993
69Vascular tortuosity (HP:0004948)1.91479668
70Bronchomalacia (HP:0002780)1.91464977
71Bowing of the arm (HP:0006488)1.90075324
72Bowed forearm bones (HP:0003956)1.90075324
73Abnormality of oral frenula (HP:0000190)1.89670194
74Difficulty climbing stairs (HP:0003551)1.88936369
75Distal lower limb muscle weakness (HP:0009053)1.87898239
76Thick nail (HP:0001805)1.87650135
77Pterygium (HP:0001059)1.87445533
78Palmoplantar hyperkeratosis (HP:0000972)1.84505651
79Neonatal death (HP:0003811)1.81926105
80Vertebral arch anomaly (HP:0008438)1.80894965
81Increased CSF protein (HP:0002922)1.79836980
82Tibial bowing (HP:0002982)1.79682654
83Spinal rigidity (HP:0003306)1.79135524
84Subacute progressive viral hepatitis (HP:0006572)1.77672071
85Heterotopia (HP:0002282)1.77671956
86Mildly elevated creatine phosphokinase (HP:0008180)1.77392261
87Long palpebral fissure (HP:0000637)1.76777497
88Recurrent viral infections (HP:0004429)1.76665542
89Blepharitis (HP:0000498)1.75478420
90Distal upper limb amyotrophy (HP:0007149)1.75347523
91Upper limb amyotrophy (HP:0009129)1.75347523
92Abnormal blistering of the skin (HP:0008066)1.74627226
93Abnormality of the calcaneus (HP:0008364)1.74417114
94Limited elbow extension (HP:0001377)1.73753288
95Asymmetry of the thorax (HP:0001555)1.73689689
96Skin ulcer (HP:0200042)1.73467902
97Mitral regurgitation (HP:0001653)1.73281700
98Disproportionate tall stature (HP:0001519)1.72836597
99Flat acetabular roof (HP:0003180)1.72809302
100Bladder diverticulum (HP:0000015)1.72732926
101Deviation of the thumb (HP:0009603)1.72383272
102Radial bowing (HP:0002986)1.72205926
103Palmar hyperkeratosis (HP:0010765)1.71733931
104Urethral obstruction (HP:0000796)1.71553777
105Biliary tract neoplasm (HP:0100574)1.71223597
106Gastrointestinal stroma tumor (HP:0100723)1.70707237
107Gastrointestinal carcinoma (HP:0002672)1.68969598
108Malignant gastrointestinal tract tumors (HP:0006749)1.68969598
109Abnormality of the acetabulum (HP:0003170)1.68845568
110Abnormal hand bone ossification (HP:0010660)1.68637390
111IgA deficiency (HP:0002720)1.68293066
112Coxa vara (HP:0002812)1.68206375
113Abnormal platelet volume (HP:0011876)1.68076471
114Malnutrition (HP:0004395)1.67997720
115Hand muscle atrophy (HP:0009130)1.67784269
116Increased mean platelet volume (HP:0011877)1.67756423
117Elbow flexion contracture (HP:0002987)1.67624119
118Autoimmune thrombocytopenia (HP:0001973)1.67622101
119Hyperacusis (HP:0010780)1.67609335
120Obstructive sleep apnea (HP:0002870)1.66520604
121Ankyloglossia (HP:0010296)1.66006911
122Distal lower limb amyotrophy (HP:0008944)1.65728418
123Abnormality of the salivary glands (HP:0010286)1.65216099
124Micronodular cirrhosis (HP:0001413)1.65014145
125Broad metatarsal (HP:0001783)1.63972263
126Peritonitis (HP:0002586)1.63693912
127Bowel diverticulosis (HP:0005222)1.63018167
128Acanthosis nigricans (HP:0000956)1.62827900
129Hypoplasia of dental enamel (HP:0006297)1.62423778
130Basal cell carcinoma (HP:0002671)1.61896270
131Abnormal foot bone ossification (HP:0010675)1.60960867
132Blue sclerae (HP:0000592)1.60567014
133Ectropion (HP:0000656)1.60308026
134Axonal loss (HP:0003447)1.60150176
135Abnormal vertebral ossification (HP:0100569)1.59948810
136Dislocated radial head (HP:0003083)1.59782500
137Macroorchidism (HP:0000053)1.59644590
138Insomnia (HP:0100785)1.59549740
139Glomerulosclerosis (HP:0000096)1.58343007
140Abnormal delayed hypersensitivity skin test (HP:0002963)1.58265534
141Sparse lateral eyebrow (HP:0005338)1.58231278
142Flattened epiphyses (HP:0003071)1.57949235
143Deep venous thrombosis (HP:0002625)1.57891758
144Proximal placement of thumb (HP:0009623)1.57597043
145Selective tooth agenesis (HP:0001592)1.56915762
146Entropion (HP:0000621)1.56751177
147Abnormal hair laboratory examination (HP:0003328)1.56679001
148Persistence of primary teeth (HP:0006335)1.56313647

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EEF2K3.72515417
2EPHA23.20536681
3MAP3K103.19201861
4TRIB32.92128032
5IRAK32.82713055
6SMG12.82502106
7MAP4K12.82063351
8ERN12.72255765
9CDK122.60511944
10PKN22.58214629
11STK102.45122827
12TTN2.42360075
13LRRK22.32410485
14PTK61.99432025
15MST41.94399278
16PRPF4B1.85086763
17RPS6KB21.62509447
18SIK11.61527697
19LATS11.57493431
20PDGFRA1.53672225
21RIPK11.49289718
22NME21.43546935
23FRK1.42965511
24TRPM71.42337809
25GRK61.41743528
26MAP3K31.34575755
27EPHB11.32406065
28FGFR41.26031904
29BMX1.23373397
30TYK21.20239485
31DDR21.17188376
32RPS6KA41.16838993
33JAK31.16417875
34MAPKAPK31.16321695
35PAK41.16210392
36CAMK1D1.09854036
37SCYL21.08758708
38TGFBR21.07701122
39LATS21.06163457
40PTK21.04800364
41CDK61.04701261
42FGFR31.04448194
43MTOR1.04396404
44JAK11.02061016
45NEK21.01840870
46ERBB40.98758311
47MAP3K20.96981812
48CSK0.95425521
49FER0.94702756
50PDGFRB0.91178601
51ITK0.91104257
52PASK0.89459111
53MAP2K30.89313829
54ZAP700.89237677
55STK30.88899699
56PAK20.87397071
57MAP3K80.86520822
58DYRK1B0.85462070
59MAP3K60.83067685
60MAP2K20.82618858
61MST1R0.82578585
62MAP3K70.82014827
63STK380.79534876
64NTRK10.79427035
65ARAF0.78824060
66BTK0.78392491
67ICK0.77989869
68FLT30.77618024
69PRKD20.76959501
70CHUK0.75791666
71PIM10.75074049
72NLK0.74596647
73HCK0.73173755
74ALK0.72398707
75CAMK1G0.69679217
76CSF1R0.69346816
77BRD40.69334780
78MAPK110.68875391
79MAP3K90.68268476
80CDK40.65111338
81HIPK20.64725138
82MAP3K140.64257510
83MELK0.63211513
84TBK10.62314265
85SIK20.62120045
86IRAK20.61226523
87LMTK20.59994970
88MET0.59795018
89TAOK10.58873584
90EPHA30.58422154
91SIK30.58422071
92RPS6KA20.57898009
93MATK0.57853128
94PDPK10.56986828
95PRKG20.56967984
96MARK30.56718023
97MAP3K10.55670846
98FGFR10.55283593
99CDK70.53332883
100TGFBR10.52956620
101CDC42BPA0.52146859
102LCK0.50877313
103KSR20.48504518
104PRKD10.48102917
105PRKCI0.47988826
106MARK20.47690656
107AURKB0.47573227
108CDK90.46855937
109RET0.46848348
110TESK10.46137140
111PIM20.45853603
112CDK80.45292507
113DMPK0.44833611
114IKBKB0.44708918
115BLK0.44373758
116INSR0.44252503
117EPHB20.44137099
118FGFR20.43494829
119MAPKAPK20.43223010
120PRKCH0.39905410
121MAP3K130.39562579
122TESK20.38993732
123IRAK40.38271517
124BRAF0.33297117
125PRKD30.32163193
126WNK10.30973395
127TAOK20.28126002
128ILK0.27523587
129MOS0.27015273
130SGK30.25688375
131RPS6KC10.23456754

Predicted pathways (KEGG)

RankGene SetZ-score
1Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.41053931
2B cell receptor signaling pathway_Homo sapiens_hsa046622.21694426
3Primary immunodeficiency_Homo sapiens_hsa053402.20544600
4Small cell lung cancer_Homo sapiens_hsa052222.12256964
5ECM-receptor interaction_Homo sapiens_hsa045122.07685088
6Adherens junction_Homo sapiens_hsa045202.02207499
7Chronic myeloid leukemia_Homo sapiens_hsa052201.87029971
8Leukocyte transendothelial migration_Homo sapiens_hsa046701.83821362
9Fatty acid biosynthesis_Homo sapiens_hsa000611.82864479
10Other glycan degradation_Homo sapiens_hsa005111.78591197
11Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.76374844
12Focal adhesion_Homo sapiens_hsa045101.72972132
13Toxoplasmosis_Homo sapiens_hsa051451.66227473
14Fructose and mannose metabolism_Homo sapiens_hsa000511.57801852
15* Proteoglycans in cancer_Homo sapiens_hsa052051.57476348
16MicroRNAs in cancer_Homo sapiens_hsa052061.55428749
17Antigen processing and presentation_Homo sapiens_hsa046121.53652409
18Bladder cancer_Homo sapiens_hsa052191.51416976
19AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.50543490
20Hematopoietic cell lineage_Homo sapiens_hsa046401.44980294
21NF-kappa B signaling pathway_Homo sapiens_hsa040641.40688922
22Acute myeloid leukemia_Homo sapiens_hsa052211.38881930
23Pancreatic cancer_Homo sapiens_hsa052121.37590061
24Amoebiasis_Homo sapiens_hsa051461.36758606
25Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.35844373
26Cyanoamino acid metabolism_Homo sapiens_hsa004601.32640396
27Osteoclast differentiation_Homo sapiens_hsa043801.31982750
28Galactose metabolism_Homo sapiens_hsa000521.25737192
29T cell receptor signaling pathway_Homo sapiens_hsa046601.24186719
30Notch signaling pathway_Homo sapiens_hsa043301.23822728
31Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.23085142
32Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.22382013
33Shigellosis_Homo sapiens_hsa051311.21784809
34p53 signaling pathway_Homo sapiens_hsa041151.21558855
35Protein digestion and absorption_Homo sapiens_hsa049741.21211317
36mTOR signaling pathway_Homo sapiens_hsa041501.21019272
37Viral myocarditis_Homo sapiens_hsa054161.19461135
38Viral carcinogenesis_Homo sapiens_hsa052031.18397578
39Insulin signaling pathway_Homo sapiens_hsa049101.18275336
40Endometrial cancer_Homo sapiens_hsa052131.17818512
41VEGF signaling pathway_Homo sapiens_hsa043701.16089607
42Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.14825727
43HTLV-I infection_Homo sapiens_hsa051661.14547641
44Non-small cell lung cancer_Homo sapiens_hsa052231.11702339
45Pentose phosphate pathway_Homo sapiens_hsa000301.10662816
46Leishmaniasis_Homo sapiens_hsa051401.10660299
47Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.10465008
48Prostate cancer_Homo sapiens_hsa052151.07754997
49Thyroid cancer_Homo sapiens_hsa052161.07476205
50Regulation of actin cytoskeleton_Homo sapiens_hsa048101.05450864
51Hepatitis B_Homo sapiens_hsa051611.05133973
52* Apoptosis_Homo sapiens_hsa042101.04609782
53* Platelet activation_Homo sapiens_hsa046111.03809524
54Tight junction_Homo sapiens_hsa045301.02953339
55Hippo signaling pathway_Homo sapiens_hsa043901.01960173
56Transcriptional misregulation in cancer_Homo sapiens_hsa052021.01541720
57Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.01168085
58Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.01147566
59N-Glycan biosynthesis_Homo sapiens_hsa005101.00529148
60Colorectal cancer_Homo sapiens_hsa052101.00526716
61Measles_Homo sapiens_hsa051621.00107707
62Glycosaminoglycan degradation_Homo sapiens_hsa005310.98414272
63TNF signaling pathway_Homo sapiens_hsa046680.96989013
64Jak-STAT signaling pathway_Homo sapiens_hsa046300.96728790
65Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.95825252
66Pathways in cancer_Homo sapiens_hsa052000.94221112
67Intestinal immune network for IgA production_Homo sapiens_hsa046720.92976919
68Lysine degradation_Homo sapiens_hsa003100.90309793
69AMPK signaling pathway_Homo sapiens_hsa041520.89332893
70Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.88689763
71Neurotrophin signaling pathway_Homo sapiens_hsa047220.88486329
72Hepatitis C_Homo sapiens_hsa051600.86001628
73Influenza A_Homo sapiens_hsa051640.85951354
74Thyroid hormone signaling pathway_Homo sapiens_hsa049190.85860426
75Renin-angiotensin system_Homo sapiens_hsa046140.85815056
76Insulin resistance_Homo sapiens_hsa049310.84970132
77Prion diseases_Homo sapiens_hsa050200.84844804
78NOD-like receptor signaling pathway_Homo sapiens_hsa046210.84237538
79Glioma_Homo sapiens_hsa052140.84123900
80Choline metabolism in cancer_Homo sapiens_hsa052310.83614160
81Herpes simplex infection_Homo sapiens_hsa051680.83514911
82Prolactin signaling pathway_Homo sapiens_hsa049170.83454526
83Salmonella infection_Homo sapiens_hsa051320.81707767
84Basal cell carcinoma_Homo sapiens_hsa052170.81642247
85TGF-beta signaling pathway_Homo sapiens_hsa043500.81042461
86PI3K-Akt signaling pathway_Homo sapiens_hsa041510.80734522
87Dorso-ventral axis formation_Homo sapiens_hsa043200.80586962
88Renal cell carcinoma_Homo sapiens_hsa052110.80239026
89Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.79167728
90Central carbon metabolism in cancer_Homo sapiens_hsa052300.78837221
91Carbohydrate digestion and absorption_Homo sapiens_hsa049730.77687357
92Biosynthesis of amino acids_Homo sapiens_hsa012300.77524062
93HIF-1 signaling pathway_Homo sapiens_hsa040660.75819919
94Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.75734681
95* GnRH signaling pathway_Homo sapiens_hsa049120.74873455
96Epstein-Barr virus infection_Homo sapiens_hsa051690.73771289
97Rap1 signaling pathway_Homo sapiens_hsa040150.71867576
98Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.71703874
99Inositol phosphate metabolism_Homo sapiens_hsa005620.71480130
100Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.71307087
101Phospholipase D signaling pathway_Homo sapiens_hsa040720.71110891
102FoxO signaling pathway_Homo sapiens_hsa040680.70976315
103Toll-like receptor signaling pathway_Homo sapiens_hsa046200.70840132
104Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.70827424
105Adipocytokine signaling pathway_Homo sapiens_hsa049200.70615288
106Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.70039230
107Chemokine signaling pathway_Homo sapiens_hsa040620.67742689
108Sphingolipid metabolism_Homo sapiens_hsa006000.67497071
109Endocytosis_Homo sapiens_hsa041440.66897845
110Tuberculosis_Homo sapiens_hsa051520.66289644
111Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.65084987
112Vibrio cholerae infection_Homo sapiens_hsa051100.64779478
113Arginine biosynthesis_Homo sapiens_hsa002200.63028999
114* Phosphatidylinositol signaling system_Homo sapiens_hsa040700.60661181
115* Estrogen signaling pathway_Homo sapiens_hsa049150.59505538
116Axon guidance_Homo sapiens_hsa043600.59261680
117Fat digestion and absorption_Homo sapiens_hsa049750.57489274
118Legionellosis_Homo sapiens_hsa051340.57431313
119Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.55391059
120Cell cycle_Homo sapiens_hsa041100.53637932
121Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.52639282
122Malaria_Homo sapiens_hsa051440.52145594
123* Thyroid hormone synthesis_Homo sapiens_hsa049180.51860393
124Melanoma_Homo sapiens_hsa052180.51460335
125ErbB signaling pathway_Homo sapiens_hsa040120.50299429
126Dilated cardiomyopathy_Homo sapiens_hsa054140.49669866
127* Glucagon signaling pathway_Homo sapiens_hsa049220.49072912
128Mineral absorption_Homo sapiens_hsa049780.48771105
129Longevity regulating pathway - mammal_Homo sapiens_hsa042110.48724885
130Sphingolipid signaling pathway_Homo sapiens_hsa040710.48337613
131Melanogenesis_Homo sapiens_hsa049160.45979182
132Bile secretion_Homo sapiens_hsa049760.44451975

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