ITPRIP

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a membrane-associated protein that binds the inositol 1,4,5-trisphosphate receptor (ITPR). The encoded protein enhances the sensitivity of ITPR to intracellular calcium signaling. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1response to peptidoglycan (GO:0032494)5.36159496
2cellular extravasation (GO:0045123)4.69201638
3modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.62937254
4positive regulation by organism of defense response of other organism involved in symbiotic interact4.62937254
5modulation by symbiont of host immune response (GO:0052553)4.62937254
6positive regulation by symbiont of host defense response (GO:0052509)4.62937254
7modulation by symbiont of host defense response (GO:0052031)4.62937254
8modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.62937254
9detection of other organism (GO:0098543)4.29195228
10negative regulation of erythrocyte differentiation (GO:0045647)4.18926746
11response to muramyl dipeptide (GO:0032495)4.17609619
12negative regulation of cell killing (GO:0031342)4.16509454
13negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.16509454
14positive regulation of gamma-delta T cell activation (GO:0046645)4.14522331
15neutrophil activation involved in immune response (GO:0002283)4.03186750
16antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.00817698
17detection of bacterium (GO:0016045)3.96578599
18macrophage activation involved in immune response (GO:0002281)3.95080455
19detection of molecule of bacterial origin (GO:0032490)3.75396493
20negative regulation of interleukin-12 production (GO:0032695)3.74342501
21detection of external biotic stimulus (GO:0098581)3.65542857
22antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.61640515
23antigen processing and presentation of endogenous antigen (GO:0019883)3.54812546
24response to laminar fluid shear stress (GO:0034616)3.49974575
25leukocyte aggregation (GO:0070486)3.47421053
26positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.43131728
27detection of biotic stimulus (GO:0009595)3.38920405
28regulation of interferon-beta biosynthetic process (GO:0045357)3.33296669
29germinal center formation (GO:0002467)3.29432453
30antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.28685855
31regulation of T-helper 2 cell differentiation (GO:0045628)3.25484344
32lipopolysaccharide-mediated signaling pathway (GO:0031663)3.24406392
33response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.22194703
34response to host immune response (GO:0052572)3.22194703
35regulation of mast cell degranulation (GO:0043304)3.21527810
36response to host (GO:0075136)3.19763325
37response to host defenses (GO:0052200)3.19763325
38response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.19763325
39neutrophil mediated immunity (GO:0002446)3.15423058
40regulation of gamma-delta T cell activation (GO:0046643)3.09298150
41regulation of B cell receptor signaling pathway (GO:0050855)3.06959152
42neutrophil activation (GO:0042119)3.06298580
43regulation of leukocyte degranulation (GO:0043300)3.03850107
44granulocyte activation (GO:0036230)3.02219109
45macrophage activation (GO:0042116)3.00312546
46regulation of mast cell activation involved in immune response (GO:0033006)2.96390916
47negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.95671890
48leukocyte migration involved in inflammatory response (GO:0002523)2.94092343
493-UTR-mediated mRNA stabilization (GO:0070935)2.93996092
50myeloid cell activation involved in immune response (GO:0002275)2.91802256
51regulation of myeloid leukocyte mediated immunity (GO:0002886)2.91761422
52negative regulation of interleukin-6 production (GO:0032715)2.90802393
53positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.90567289
54respiratory burst (GO:0045730)2.90230637
55tolerance induction (GO:0002507)2.86378882
56immunoglobulin mediated immune response (GO:0016064)2.85346578
57negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.83548835
58negative regulation of interleukin-8 production (GO:0032717)2.82863837
59regulation of dendritic cell antigen processing and presentation (GO:0002604)2.78554392
60negative regulation of lymphocyte mediated immunity (GO:0002707)2.76353698
61regulation of macrophage cytokine production (GO:0010935)2.74235021
62positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.72865683
63embryonic process involved in female pregnancy (GO:0060136)2.69615383
64regulation of mast cell activation (GO:0033003)2.67563371
65negative regulation of leukocyte mediated immunity (GO:0002704)2.65276911
66protein localization to endosome (GO:0036010)2.64975258
67pinocytosis (GO:0006907)2.64315567
68positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003602.64082653
69NIK/NF-kappaB signaling (GO:0038061)2.61279619
70production of molecular mediator involved in inflammatory response (GO:0002532)2.61000169
71negative regulation of toll-like receptor signaling pathway (GO:0034122)2.60662053
72regulation of gamma-delta T cell differentiation (GO:0045586)2.59802042
73negative regulation of glycoprotein biosynthetic process (GO:0010561)2.55974171
74negative regulation of T-helper cell differentiation (GO:0045623)2.55237388
75negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.55237388
76mannose metabolic process (GO:0006013)2.55203599
77positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.54531990
78positive regulation of mast cell activation (GO:0033005)2.54193202
79microglial cell activation (GO:0001774)2.53935811
80regulation of tolerance induction (GO:0002643)2.53663294
81regulation of T cell tolerance induction (GO:0002664)2.53239563
82defense response to protozoan (GO:0042832)2.51962147
83myeloid leukocyte mediated immunity (GO:0002444)2.51656331
84T-helper 1 type immune response (GO:0042088)2.50155182
85negative regulation of T cell mediated immunity (GO:0002710)2.49427240
86regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.48742145
87hypotonic response (GO:0006971)2.47989542
88cellular response to type I interferon (GO:0071357)2.47366698
89type I interferon signaling pathway (GO:0060337)2.47366698
90neutrophil chemotaxis (GO:0030593)2.46789959
91response to type I interferon (GO:0034340)2.45902361
92leukocyte degranulation (GO:0043299)2.45250334
93negative regulation of innate immune response (GO:0045824)2.44738067
94negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.43112106
95negative regulation of cytokine production involved in immune response (GO:0002719)2.42579466
96antigen processing and presentation via MHC class Ib (GO:0002475)2.40277015
97neutrophil migration (GO:1990266)2.39663926
98regulation of interleukin-6 production (GO:0032675)2.39457781
99regulation of necroptotic process (GO:0060544)2.38954410
100establishment of endothelial barrier (GO:0061028)2.37448157

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human3.56760820
2EGR1_19374776_ChIP-ChIP_THP-1_Human3.45838977
3NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.21555493
4IRF8_22096565_ChIP-ChIP_GC-B_Human3.17484349
5TP63_17297297_ChIP-ChIP_HaCaT_Human3.03201339
6FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.00596168
7STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.90835862
8VDR_21846776_ChIP-Seq_THP-1_Human2.82986434
9MYB_21317192_ChIP-Seq_ERMYB_Mouse2.79434225
10SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.77181157
11* MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.75515666
12NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.58964190
13VDR_24763502_ChIP-Seq_THP-1_Human2.51175600
14KDM2B_26808549_Chip-Seq_SUP-B15_Human2.44952675
15NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.44587638
16* ELK3_25401928_ChIP-Seq_HUVEC_Human2.43872703
17MYC_22102868_ChIP-Seq_BL_Human2.36688714
18IRF8_21731497_ChIP-ChIP_J774_Mouse2.27748647
19* TCF7_22412390_ChIP-Seq_EML_Mouse2.24643197
20IRF8_27001747_Chip-Seq_BMDM_Mouse2.24028713
21* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.18165968
22* KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.15473019
23MAF_26560356_Chip-Seq_TH1_Human2.13729627
24STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.11449404
25BRD4_27068464_Chip-Seq_AML-cells_Mouse2.08994067
26* KDM2B_26808549_Chip-Seq_DND41_Human2.05847323
27SMAD_19615063_ChIP-ChIP_OVARY_Human2.01273418
28RARG_19884340_ChIP-ChIP_MEFs_Mouse1.91874717
29SCL_19346495_ChIP-Seq_HPC-7_Human1.91126529
30RUNX1_22412390_ChIP-Seq_EML_Mouse1.90801487
31RUNX_20019798_ChIP-Seq_JUKART_Human1.89869228
32Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.89835953
33TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.89424854
34SPI1_23127762_ChIP-Seq_K562_Human1.86922336
35RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.86477965
36VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.84319968
37STAT4_19710469_ChIP-ChIP_TH1__Mouse1.81727016
38SPI1_23547873_ChIP-Seq_NB4_Human1.79133165
39* UTX_26944678_Chip-Seq_JUKART_Human1.77023933
40FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.74281411
41* KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.73404571
42STAT6_21828071_ChIP-Seq_BEAS2B_Human1.71316894
43THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.69195590
44STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.65332957
45E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.63352234
46TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.63278985
47GATA2_21666600_ChIP-Seq_HMVEC_Human1.60996618
48TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.60360111
49SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.58002098
50* LXR_22292898_ChIP-Seq_THP-1_Human1.57422013
51* KDM2B_26808549_Chip-Seq_JURKAT_Human1.56410086
52RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.56144243
53VDR_24787735_ChIP-Seq_THP-1_Human1.54405634
54MYB_26560356_Chip-Seq_TH2_Human1.54297889
55MAF_26560356_Chip-Seq_TH2_Human1.51807239
56* MYB_26560356_Chip-Seq_TH1_Human1.49418854
57GATA1_19941826_ChIP-Seq_K562_Human1.45077858
58CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.44303152
59MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.43947362
60* RACK7_27058665_Chip-Seq_MCF-7_Human1.32886428
61IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.31367663
62* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.30331506
63GATA1_19941827_ChIP-Seq_MEL_Mouse1.29538668
64KDM2B_26808549_Chip-Seq_K562_Human1.29015779
65* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.28113838
66CLOCK_20551151_ChIP-Seq_293T_Human1.24712736
67* NCOR1_26117541_ChIP-Seq_K562_Human1.21931158
68* CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.19017763
69SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.18597413
70SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.18597413
71ESR2_21235772_ChIP-Seq_MCF-7_Human1.17059147
72FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.17016767
73* P300_27058665_Chip-Seq_ZR-75-30cells_Human1.16627165
74PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.14252372
75PU_27001747_Chip-Seq_BMDM_Mouse1.14065391
76PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.11628100
77ATF3_27146783_Chip-Seq_COLON_Human1.11227489
78BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.10672879
79* GATA2_22383799_ChIP-Seq_G1ME_Mouse1.10029401
80TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.09956650
81* CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.08485917
82CTCF_27219007_Chip-Seq_ERYTHROID_Human1.08444086
83* UBF1/2_26484160_Chip-Seq_HMECs_Human1.07843371
84* NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.07796589
85GATA1_22383799_ChIP-Seq_G1ME_Mouse1.06127422
86PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.05870356
87ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.05408483
88IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.04583064
89GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.04069130
90LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.02964031
91SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.02801726
92* GATA2_19941826_ChIP-Seq_K562_Human1.02607487
93* JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.02266071
94* ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.98935523
95CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.98147940
96TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.96771338
97* UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.95243171
98SMC1_22415368_ChIP-Seq_MEFs_Mouse0.93613561
99SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.93496322
100SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.93217504

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003436_decreased_susceptibility_to3.91054366
2MP0003724_increased_susceptibility_to3.38188427
3MP0003303_peritoneal_inflammation3.06502599
4MP0003828_pulmonary_edema2.76598083
5MP0002419_abnormal_innate_immunity2.57189755
6MP0003191_abnormal_cellular_cholesterol2.50119510
7MP0009278_abnormal_bone_marrow2.41727465
8MP0001835_abnormal_antigen_presentation2.38259912
9MP0003300_gastrointestinal_ulcer2.28860394
10MP0003705_abnormal_hypodermis_morpholog2.28379684
11MP0003566_abnormal_cell_adhesion2.17216687
12MP0005000_abnormal_immune_tolerance2.17069055
13MP0008260_abnormal_autophagy2.15517815
14MP0004947_skin_inflammation2.12191497
15MP0005025_abnormal_response_to2.12137650
16MP0000685_abnormal_immune_system2.07590822
17MP0001533_abnormal_skeleton_physiology2.04175479
18MP0009785_altered_susceptibility_to2.02123918
19MP0004510_myositis1.95263856
20MP0001790_abnormal_immune_system1.92324579
21MP0005387_immune_system_phenotype1.92324579
22MP0001800_abnormal_humoral_immune1.88459588
23MP0002452_abnormal_antigen_presenting1.87297355
24MP0002723_abnormal_immune_serum1.85230281
25MP0006082_CNS_inflammation1.84671428
26MP0003091_abnormal_cell_migration1.83025494
27MP0005451_abnormal_body_composition1.81000249
28MP0008438_abnormal_cutaneous_collagen1.80825837
29MP0002148_abnormal_hypersensitivity_rea1.79865862
30MP0002420_abnormal_adaptive_immunity1.79843146
31MP0001819_abnormal_immune_cell1.77791579
32MP0005076_abnormal_cell_differentiation1.76265597
33MP0009840_abnormal_foam_cell1.73705125
34MP0002405_respiratory_system_inflammati1.73398265
35MP0003763_abnormal_thymus_physiology1.71446935
36MP0003172_abnormal_lysosome_physiology1.66962823
37MP0002998_abnormal_bone_remodeling1.66748685
38MP0001851_eye_inflammation1.63027969
39MP0005397_hematopoietic_system_phenotyp1.61368798
40MP0001545_abnormal_hematopoietic_system1.61368798
41MP0005464_abnormal_platelet_physiology1.52495705
42MP0004808_abnormal_hematopoietic_stem1.51899837
43MP0003279_aneurysm1.51745728
44MP0005058_abnormal_lysosome_morphology1.51485914
45MP0000858_altered_metastatic_potential1.50155019
46MP0005164_abnormal_response_to1.46878129
47MP0009764_decreased_sensitivity_to1.43067451
48MP0002398_abnormal_bone_marrow1.37747980
49MP0005023_abnormal_wound_healing1.37425099
50MP0000343_altered_response_to1.36858683
51MP0009333_abnormal_splenocyte_physiolog1.36168149
52MP0005671_abnormal_response_to1.35829701
53MP0010155_abnormal_intestine_physiology1.35475415
54MP0000716_abnormal_immune_system1.32294981
55MP0003453_abnormal_keratinocyte_physiol1.30668188
56MP0001845_abnormal_inflammatory_respons1.30182990
57MP0001853_heart_inflammation1.28481786
58MP0003448_altered_tumor_morphology1.27215717
59MP0003656_abnormal_erythrocyte_physiolo1.27060672
60MP0000465_gastrointestinal_hemorrhage1.25186004
61MP0002396_abnormal_hematopoietic_system1.24002679
62MP0004883_abnormal_blood_vessel1.23561554
63MP0005390_skeleton_phenotype1.20591401
64MP0001958_emphysema1.18964114
65MP0002722_abnormal_immune_system1.16431141
66* MP0003075_altered_response_to1.14378844
67MP0000767_abnormal_smooth_muscle1.13818666
68MP0002877_abnormal_melanocyte_morpholog1.13302517
69MP0002166_altered_tumor_susceptibility1.12837275
70MP0002332_abnormal_exercise_endurance1.11246707
71MP0002429_abnormal_blood_cell1.10347421
72MP0002060_abnormal_skin_morphology1.09861204
73MP0008469_abnormal_protein_level1.08459905
74MP0002009_preneoplasia1.08426925
75MP0008004_abnormal_stomach_pH1.07124874
76MP0005166_decreased_susceptibility_to1.06241744
77MP0002933_joint_inflammation1.06138958
78MP0000689_abnormal_spleen_morphology1.03743252
79MP0010352_gastrointestinal_tract_polyps1.02043930
80MP0000703_abnormal_thymus_morphology1.00104399
81MP0000249_abnormal_blood_vessel0.98183831
82MP0005275_abnormal_skin_tensile0.97686190
83MP0002796_impaired_skin_barrier0.91903271
84MP0002132_abnormal_respiratory_system0.90368495
85MP0002006_tumorigenesis0.89281843
86MP0010368_abnormal_lymphatic_system0.88584322
87MP0005409_darkened_coat_color0.85753573
88MP0003795_abnormal_bone_structure0.81563959
89MP0003221_abnormal_cardiomyocyte_apopto0.81142396
90MP0004381_abnormal_hair_follicle0.80908131
91MP0001849_ear_inflammation0.80368015
92MP0009763_increased_sensitivity_to0.80002059
93MP0003950_abnormal_plasma_membrane0.79260972
94MP0001542_abnormal_bone_strength0.78511217
95MP0003045_fibrosis0.77443051
96MP0005310_abnormal_salivary_gland0.75672738
97MP0009931_abnormal_skin_appearance0.73645623
98MP0002254_reproductive_system_inflammat0.73054172
99* MP0005621_abnormal_cell_physiology0.72819589
100MP0000604_amyloidosis0.72720713

Predicted human phenotypes

RankGene SetZ-score
1Eczematoid dermatitis (HP:0000976)4.92840214
2Abnormality of macrophages (HP:0004311)4.16806548
3Recurrent bacterial skin infections (HP:0005406)3.92148109
4Recurrent abscess formation (HP:0002722)3.82214255
5Myositis (HP:0100614)3.82207581
6Elevated erythrocyte sedimentation rate (HP:0003565)3.79980141
7Orchitis (HP:0100796)3.60904396
8Increased IgE level (HP:0003212)3.22357695
9Stomatitis (HP:0010280)3.19246614
10Retrobulbar optic neuritis (HP:0100654)3.16950483
11Optic neuritis (HP:0100653)3.16950483
12Recurrent gram-negative bacterial infections (HP:0005420)3.04417384
13Spontaneous hematomas (HP:0007420)2.97284458
14Mediastinal lymphadenopathy (HP:0100721)2.90843802
15Cellulitis (HP:0100658)2.81977019
16Gastrointestinal infarctions (HP:0005244)2.77610071
17Amyloidosis (HP:0011034)2.76199620
18Peritonitis (HP:0002586)2.76037128
19Recurrent fungal infections (HP:0002841)2.69156775
20Protrusio acetabuli (HP:0003179)2.63695835
21Abnormal delayed hypersensitivity skin test (HP:0002963)2.60840109
22Urticaria (HP:0001025)2.58053869
23Recurrent skin infections (HP:0001581)2.57920587
24Episodic fever (HP:0001954)2.54938816
25Gingivitis (HP:0000230)2.54511918
26Abnormality of glycolipid metabolism (HP:0010969)2.51416129
27Abnormality of liposaccharide metabolism (HP:0010968)2.51416129
28Abnormality of glycosphingolipid metabolism (HP:0004343)2.51416129
29Keratoconjunctivitis sicca (HP:0001097)2.50514977
30Increased connective tissue (HP:0009025)2.48963092
31Chronic obstructive pulmonary disease (HP:0006510)2.45592981
32Obstructive lung disease (HP:0006536)2.45592981
33Polycythemia (HP:0001901)2.44178461
34Spondylolisthesis (HP:0003302)2.41616250
35Chronic mucocutaneous candidiasis (HP:0002728)2.40473687
36Recurrent cutaneous fungal infections (HP:0011370)2.40473687
37Premature rupture of membranes (HP:0001788)2.36553790
38Vasculitis (HP:0002633)2.31630597
39Meningitis (HP:0001287)2.31301745
40Vertebral compression fractures (HP:0002953)2.27975077
41Segmental peripheral demyelination/remyelination (HP:0003481)2.27727041
42Pustule (HP:0200039)2.27470858
43Broad face (HP:0000283)2.26448589
44Dilatation of the ascending aorta (HP:0005111)2.25732203
45Keratoconjunctivitis (HP:0001096)2.25239269
46Prolonged bleeding time (HP:0003010)2.22869967
47Pulmonary infiltrates (HP:0002113)2.20305387
48Epistaxis (HP:0000421)2.20118208
49Distal lower limb amyotrophy (HP:0008944)2.18908323
50Chest pain (HP:0100749)2.18122571
51Interstitial pulmonary disease (HP:0006530)2.17242520
52Aortic aneurysm (HP:0004942)2.16954616
53Loss of speech (HP:0002371)2.13932093
54Cerebral aneurysm (HP:0004944)2.12613060
55Thick nail (HP:0001805)2.10375111
56Fatigue (HP:0012378)2.10286323
57Increased cerebral lipofuscin (HP:0011813)2.10101662
58Hemoptysis (HP:0002105)2.08905723
59Myocardial infarction (HP:0001658)2.08381951
60Abnormality of the peritoneum (HP:0002585)2.07769530
61Arterial thrombosis (HP:0004420)2.05983985
62Dysostosis multiplex (HP:0000943)2.05145019
63Distal lower limb muscle weakness (HP:0009053)2.02106112
64Leukocytosis (HP:0001974)2.01069294
65Recurrent viral infections (HP:0004429)2.00316289
66Increased variability in muscle fiber diameter (HP:0003557)1.97286070
67Gingival bleeding (HP:0000225)1.95764997
68Subacute progressive viral hepatitis (HP:0006572)1.94293509
69Osteomyelitis (HP:0002754)1.92616617
70Hematochezia (HP:0002573)1.90938958
71Skin ulcer (HP:0200042)1.90406391
72Disproportionate tall stature (HP:0001519)1.89215579
73Slow saccadic eye movements (HP:0000514)1.86651828
74Glomerulopathy (HP:0100820)1.86586998
75Syringomyelia (HP:0003396)1.86471651
76Spinal cord lesions (HP:0100561)1.86471651
77Hypergammaglobulinemia (HP:0010702)1.84417486
78Muscle fiber splitting (HP:0003555)1.84357518
79Osteolytic defects of the hand bones (HP:0009699)1.84139817
80Osteolytic defects of the phalanges of the hand (HP:0009771)1.84139817
81Abnormality of skeletal muscle fiber size (HP:0012084)1.83446401
82Abnormal platelet volume (HP:0011876)1.82357228
83Atrophic scars (HP:0001075)1.82352568
84Autoimmune thrombocytopenia (HP:0001973)1.81809368
85Aortic dissection (HP:0002647)1.81807708
86Increased serum ferritin (HP:0003281)1.81467335
87Dislocated radial head (HP:0003083)1.81083813
88Aneurysm (HP:0002617)1.79517784
89Difficulty climbing stairs (HP:0003551)1.78919942
90Polygenic inheritance (HP:0010982)1.77284748
91Anorexia (HP:0002039)1.76424921
92Granulocytopenia (HP:0001913)1.76317986
93Inflammation of the large intestine (HP:0002037)1.75279129
94Cervical subluxation (HP:0003308)1.75151343
95Genu recurvatum (HP:0002816)1.74575469
96Encephalitis (HP:0002383)1.74390043
97Asymmetric septal hypertrophy (HP:0001670)1.73978776
98Abnormality of the pericardium (HP:0001697)1.73695936
99Fragile skin (HP:0001030)1.72236429
100Gastrointestinal inflammation (HP:0004386)1.71933942

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PRPF4B3.55037053
2MAP2K33.23477301
3RIPK42.91819855
4ERN12.88868198
5MAP3K32.48836550
6IRAK42.43965084
7BLK2.41317454
8EPHB12.38835785
9MAP4K12.19210632
10ZAP702.09341060
11IRAK32.08406929
12TYK21.92485685
13MAP3K141.91898433
14CSK1.87526013
15TTN1.76691801
16TRIB31.74182306
17TAOK21.74057484
18TGFBR21.67891227
19JAK31.67525386
20TAOK11.65587727
21CDK121.64092726
22MAP3K131.61188981
23IKBKE1.45518277
24FES1.43803140
25TBK11.43117401
26SIK11.41482555
27GRK61.40485347
28MAP3K11.39766512
29MAP3K61.39300568
30MAP3K111.38633383
31IRAK11.31296812
32IRAK21.27104101
33HCK1.27067614
34SIK31.21378316
35MAPK71.19634977
36ICK1.18568598
37RIPK11.18302170
38MARK21.17196833
39KSR21.15093659
40MOS1.14300070
41PRKD21.13633481
42SMG11.10711127
43BTK1.10495607
44FGR1.01709836
45IKBKB0.99357735
46CDC42BPA0.96307737
47JAK10.94696440
48MAPK120.91115525
49PDK20.90928596
50STK100.89648463
51KIT0.87635595
52PTK60.87049871
53BMPR20.86166473
54SYK0.85953903
55JAK20.82798015
56TNK20.78811618
57MAP3K70.77253852
58PDGFRB0.75639754
59LCK0.74495741
60RPS6KC10.73897076
61RPS6KL10.73897076
62PIK3CG0.73728225
63PIM20.72225060
64TXK0.72140431
65MARK30.71559405
66PDPK10.71484930
67PAK40.71103539
68HIPK20.68875712
69CHUK0.67628415
70LYN0.67570553
71YES10.66592224
72MTOR0.64608481
73ITK0.62862638
74PTK2B0.61597381
75CAMK1D0.60997802
76CLK10.60891304
77RAF10.58420457
78WNK10.58387075
79PDGFRA0.57629470
80RPS6KA60.57437595
81FGFR40.55188431
82STK380.54869555
83PDK10.54827812
84MAPKAPK20.54406234
85RPS6KA20.53657009
86EPHA30.52938514
87MATK0.52331930
88TESK20.52323571
89PTK20.52259878
90TRPM70.51319225
91MAP3K80.50897494
92SGK30.49633912
93PIM10.49254450
94MAP3K50.48868553
95MAP3K20.47931870
96CDK60.47357101
97CSF1R0.46843455
98BMX0.44572754
99ARAF0.44561410
100GSK3A0.44323349

Predicted pathways (KEGG)

RankGene SetZ-score
1Osteoclast differentiation_Homo sapiens_hsa043802.62331758
2Leishmaniasis_Homo sapiens_hsa051402.34602203
3Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.26180365
4Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005322.18081424
5Malaria_Homo sapiens_hsa051442.05503526
6Acute myeloid leukemia_Homo sapiens_hsa052211.92084919
7Toll-like receptor signaling pathway_Homo sapiens_hsa046201.84540486
8B cell receptor signaling pathway_Homo sapiens_hsa046621.80439863
9NOD-like receptor signaling pathway_Homo sapiens_hsa046211.80432169
10TNF signaling pathway_Homo sapiens_hsa046681.74717488
11Other glycan degradation_Homo sapiens_hsa005111.72470766
12Tuberculosis_Homo sapiens_hsa051521.71193681
13Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.68055330
14NF-kappa B signaling pathway_Homo sapiens_hsa040641.63447577
15Staphylococcus aureus infection_Homo sapiens_hsa051501.62060006
16Chronic myeloid leukemia_Homo sapiens_hsa052201.59995703
17Toxoplasmosis_Homo sapiens_hsa051451.58351668
18Legionellosis_Homo sapiens_hsa051341.50386183
19AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.46611526
20Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.46135641
21Measles_Homo sapiens_hsa051621.45512628
22Influenza A_Homo sapiens_hsa051641.44928497
23Hepatitis B_Homo sapiens_hsa051611.38835204
24Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.37834485
25Non-small cell lung cancer_Homo sapiens_hsa052231.36231570
26Pancreatic cancer_Homo sapiens_hsa052121.35221317
27Amoebiasis_Homo sapiens_hsa051461.34366663
28Hematopoietic cell lineage_Homo sapiens_hsa046401.31040929
29Renal cell carcinoma_Homo sapiens_hsa052111.29921618
30Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.29673456
31VEGF signaling pathway_Homo sapiens_hsa043701.28013827
32Jak-STAT signaling pathway_Homo sapiens_hsa046301.27726172
33Pertussis_Homo sapiens_hsa051331.27131360
34RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.26815166
35Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.25138831
36Bladder cancer_Homo sapiens_hsa052191.25066358
37T cell receptor signaling pathway_Homo sapiens_hsa046601.23731917
38Chemokine signaling pathway_Homo sapiens_hsa040621.22970190
39Graft-versus-host disease_Homo sapiens_hsa053321.22412715
40Shigellosis_Homo sapiens_hsa051311.22312659
41Notch signaling pathway_Homo sapiens_hsa043301.20364175
42Leukocyte transendothelial migration_Homo sapiens_hsa046701.19527566
43Salmonella infection_Homo sapiens_hsa051321.16863219
44Apoptosis_Homo sapiens_hsa042101.12824177
45Glycosaminoglycan degradation_Homo sapiens_hsa005311.12624858
46Viral myocarditis_Homo sapiens_hsa054161.12023862
47Hepatitis C_Homo sapiens_hsa051601.08278958
48African trypanosomiasis_Homo sapiens_hsa051431.08260998
49Neurotrophin signaling pathway_Homo sapiens_hsa047221.06375270
50Phagosome_Homo sapiens_hsa041451.06354858
51Herpes simplex infection_Homo sapiens_hsa051681.06251512
52Allograft rejection_Homo sapiens_hsa053301.01009981
53Platelet activation_Homo sapiens_hsa046110.99875283
54Small cell lung cancer_Homo sapiens_hsa052220.99124761
55Lysosome_Homo sapiens_hsa041420.97013080
56FoxO signaling pathway_Homo sapiens_hsa040680.94194060
57Endometrial cancer_Homo sapiens_hsa052130.92438116
58Rheumatoid arthritis_Homo sapiens_hsa053230.91309294
59Prolactin signaling pathway_Homo sapiens_hsa049170.90923199
60Autoimmune thyroid disease_Homo sapiens_hsa053200.89974624
61Focal adhesion_Homo sapiens_hsa045100.89179321
62Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.87894203
63HIF-1 signaling pathway_Homo sapiens_hsa040660.87279268
64Dorso-ventral axis formation_Homo sapiens_hsa043200.87170944
65GnRH signaling pathway_Homo sapiens_hsa049120.85218276
66Proteoglycans in cancer_Homo sapiens_hsa052050.84365157
67Phospholipase D signaling pathway_Homo sapiens_hsa040720.84248786
68Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.82153408
69HTLV-I infection_Homo sapiens_hsa051660.79293859
70Prostate cancer_Homo sapiens_hsa052150.78943861
71Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.78689012
72Antigen processing and presentation_Homo sapiens_hsa046120.78351587
73Viral carcinogenesis_Homo sapiens_hsa052030.77829125
74mTOR signaling pathway_Homo sapiens_hsa041500.77718602
75Colorectal cancer_Homo sapiens_hsa052100.74910417
76Primary immunodeficiency_Homo sapiens_hsa053400.74653857
77Central carbon metabolism in cancer_Homo sapiens_hsa052300.74463730
78Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.74341358
79Sphingolipid signaling pathway_Homo sapiens_hsa040710.74198445
80Insulin resistance_Homo sapiens_hsa049310.73711855
81ErbB signaling pathway_Homo sapiens_hsa040120.73629151
82Endocytosis_Homo sapiens_hsa041440.72730534
83MicroRNAs in cancer_Homo sapiens_hsa052060.71934976
84Adipocytokine signaling pathway_Homo sapiens_hsa049200.71354947
85Choline metabolism in cancer_Homo sapiens_hsa052310.70337673
86MAPK signaling pathway_Homo sapiens_hsa040100.68245067
87Regulation of actin cytoskeleton_Homo sapiens_hsa048100.67717014
88Transcriptional misregulation in cancer_Homo sapiens_hsa052020.62192233
89Thyroid cancer_Homo sapiens_hsa052160.59793517
90Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.59692938
91Pathways in cancer_Homo sapiens_hsa052000.59681383
92Glioma_Homo sapiens_hsa052140.58797492
93Intestinal immune network for IgA production_Homo sapiens_hsa046720.58406541
94Prion diseases_Homo sapiens_hsa050200.58203992
95Epstein-Barr virus infection_Homo sapiens_hsa051690.57787093
96Thyroid hormone signaling pathway_Homo sapiens_hsa049190.56535954
97Phosphatidylinositol signaling system_Homo sapiens_hsa040700.56468963
98Longevity regulating pathway - mammal_Homo sapiens_hsa042110.55707209
99Type I diabetes mellitus_Homo sapiens_hsa049400.53940336
100Insulin signaling pathway_Homo sapiens_hsa049100.52755345

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