ITPRIPL1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1behavioral response to nicotine (GO:0035095)5.23709325
2DNA deamination (GO:0045006)4.85803477
3telomere maintenance via semi-conservative replication (GO:0032201)4.16141339
4pinocytosis (GO:0006907)4.11680679
5regulation of B cell receptor signaling pathway (GO:0050855)4.08390578
6ribosomal small subunit assembly (GO:0000028)4.02497421
7regulation of interferon-beta biosynthetic process (GO:0045357)3.95126060
8telomere maintenance via recombination (GO:0000722)3.92552599
9negative regulation of phagocytosis (GO:0050765)3.92252180
10positive regulation of interferon-alpha production (GO:0032727)3.82343726
11production of molecular mediator involved in inflammatory response (GO:0002532)3.79114951
12DNA strand elongation involved in DNA replication (GO:0006271)3.76884685
13cellular response to exogenous dsRNA (GO:0071360)3.76859101
14mitotic recombination (GO:0006312)3.65454844
15DNA replication checkpoint (GO:0000076)3.64967298
16regulation of interferon-alpha production (GO:0032647)3.60548133
17DNA strand elongation (GO:0022616)3.59817080
18antigen processing and presentation of endogenous antigen (GO:0019883)3.55185937
19pseudouridine synthesis (GO:0001522)3.47782196
20RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)3.47110100
21cellular response to interferon-beta (GO:0035458)3.44511534
22neutrophil activation involved in immune response (GO:0002283)3.38392412
23protein complex biogenesis (GO:0070271)3.31430785
24positive regulation of antigen processing and presentation (GO:0002579)3.29473613
25negative regulation of mast cell activation (GO:0033004)3.26684677
26protein K6-linked ubiquitination (GO:0085020)3.26266861
27regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.26001842
28replication fork processing (GO:0031297)3.24497637
29L-fucose catabolic process (GO:0042355)3.24278729
30fucose catabolic process (GO:0019317)3.24278729
31L-fucose metabolic process (GO:0042354)3.24278729
32indolalkylamine metabolic process (GO:0006586)3.23138096
33mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.20388518
34mitochondrial respiratory chain complex I assembly (GO:0032981)3.20388518
35NADH dehydrogenase complex assembly (GO:0010257)3.20388518
36immunoglobulin mediated immune response (GO:0016064)3.20166717
37mitochondrial respiratory chain complex assembly (GO:0033108)3.19145318
38DNA double-strand break processing (GO:0000729)3.18764558
39telomere maintenance via telomere lengthening (GO:0010833)3.15680353
40mast cell activation (GO:0045576)3.15352645
41Arp2/3 complex-mediated actin nucleation (GO:0034314)3.14016153
42water-soluble vitamin biosynthetic process (GO:0042364)3.12909554
43rRNA catabolic process (GO:0016075)3.11144633
44nucleotide-excision repair, DNA gap filling (GO:0006297)3.07708845
45DNA replication initiation (GO:0006270)3.06287142
46sulfation (GO:0051923)3.05852886
47positive regulation of B cell differentiation (GO:0045579)3.05557138
48definitive hemopoiesis (GO:0060216)3.03733394
49meiotic chromosome segregation (GO:0045132)3.03727236
50somatic diversification of immune receptors via somatic mutation (GO:0002566)3.02658021
51somatic hypermutation of immunoglobulin genes (GO:0016446)3.02658021
52activated T cell proliferation (GO:0050798)3.01474805
53negative regulation by host of viral transcription (GO:0043922)2.98829406
54exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.98818384
55dendritic cell chemotaxis (GO:0002407)2.98750309
56kinetochore organization (GO:0051383)2.98491633
57regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.97718915
58negative regulation of transcription regulatory region DNA binding (GO:2000678)2.97025643
59G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)2.96850879
60antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.96106339
61regulation of DNA endoreduplication (GO:0032875)2.95441601
62positive regulation of defense response to virus by host (GO:0002230)2.95302548
63double-strand break repair via homologous recombination (GO:0000724)2.95240041
64tryptophan catabolic process (GO:0006569)2.94874448
65indole-containing compound catabolic process (GO:0042436)2.94874448
66indolalkylamine catabolic process (GO:0046218)2.94874448
67cellular response to ATP (GO:0071318)2.94581491
68nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.94557041
69respiratory burst (GO:0045730)2.94133553
70signal peptide processing (GO:0006465)2.94085469
71recombinational repair (GO:0000725)2.93686883
72modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.93216996
73positive regulation by organism of defense response of other organism involved in symbiotic interact2.93216996
74modulation by symbiont of host immune response (GO:0052553)2.93216996
75positive regulation by symbiont of host defense response (GO:0052509)2.93216996
76modulation by symbiont of host defense response (GO:0052031)2.93216996
77modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.93216996
78kynurenine metabolic process (GO:0070189)2.93215796
79CENP-A containing nucleosome assembly (GO:0034080)2.93135697
80centriole replication (GO:0007099)2.91809616
81regulation of antigen processing and presentation (GO:0002577)2.90961983
82response to pheromone (GO:0019236)2.88995625
83negative regulation of B cell proliferation (GO:0030889)2.87765490
84cytidine metabolic process (GO:0046087)2.87650977
85cytidine catabolic process (GO:0006216)2.87650977
86cytidine deamination (GO:0009972)2.87650977
87regulation of B cell differentiation (GO:0045577)2.87243775
88IMP biosynthetic process (GO:0006188)2.86153864
89regulation of dendritic cell antigen processing and presentation (GO:0002604)2.86135603
90response to interferon-beta (GO:0035456)2.84735369
91cytochrome complex assembly (GO:0017004)2.84492995
92myeloid dendritic cell activation (GO:0001773)2.83617910
93establishment of protein localization to mitochondrial membrane (GO:0090151)2.82492308
94negative regulation of DNA-dependent DNA replication (GO:2000104)2.82075002
95microglial cell activation (GO:0001774)2.81423922
96histamine secretion (GO:0001821)2.81115789
97chromatin remodeling at centromere (GO:0031055)2.79893508
98transcription elongation from RNA polymerase III promoter (GO:0006385)2.79579320
99termination of RNA polymerase III transcription (GO:0006386)2.79579320
100maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.78451589
101negative regulation of telomere maintenance (GO:0032205)2.77890876
102attachment of spindle microtubules to kinetochore (GO:0008608)2.77880627
103megakaryocyte development (GO:0035855)2.77673273
104rRNA modification (GO:0000154)2.75334052
105RNA destabilization (GO:0050779)2.74776586
106telomere maintenance (GO:0000723)2.74712372
107somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.74694285
108isotype switching (GO:0045190)2.74694285
109somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.74694285
110antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.74568982
111antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.74568982
112positive regulation of monocyte chemotaxis (GO:0090026)2.74362507
113dendritic cell migration (GO:0036336)2.74136472
114angiogenesis involved in wound healing (GO:0060055)2.73269946
115telomere organization (GO:0032200)2.72773241
116interferon-gamma production (GO:0032609)2.71331814
117pore complex assembly (GO:0046931)2.70491083
118lipoxygenase pathway (GO:0019372)2.68024463
119tryptophan metabolic process (GO:0006568)2.66798111
120tolerance induction (GO:0002507)2.65812223
121protein K11-linked deubiquitination (GO:0035871)2.65241721
122positive regulation of T cell migration (GO:2000406)2.65112073
123synapsis (GO:0007129)2.64003506
124protein polyglutamylation (GO:0018095)2.63279366
125rRNA methylation (GO:0031167)2.63084553
126glycosphingolipid catabolic process (GO:0046479)2.62928179
127positive regulation of interferon-beta production (GO:0032728)2.62580357
128somatic diversification of immunoglobulins (GO:0016445)2.60898949
129B cell mediated immunity (GO:0019724)2.60788884
130respiratory chain complex IV assembly (GO:0008535)2.59716790
131negative regulation of growth of symbiont in host (GO:0044130)2.58260314
132negative regulation of growth of symbiont involved in interaction with host (GO:0044146)2.58260314
133modulation of growth of symbiont involved in interaction with host (GO:0044144)2.58260314
134regulation of growth of symbiont in host (GO:0044126)2.58260314
135superoxide anion generation (GO:0042554)2.57132200
136regulation of posttranscriptional gene silencing (GO:0060147)2.56833439
137regulation of gene silencing by miRNA (GO:0060964)2.56833439
138regulation of gene silencing by RNA (GO:0060966)2.56833439
139response to peptidoglycan (GO:0032494)2.56305537
140heart process (GO:0003015)2.56226860
141heart contraction (GO:0060047)2.56226860
142regulation of double-strand break repair via homologous recombination (GO:0010569)2.55975250
143phagocytosis, engulfment (GO:0006911)2.55510583
144positive regulation of T cell chemotaxis (GO:0010820)2.54523912
145regulation of T cell chemotaxis (GO:0010819)2.54523912
146DNA strand renaturation (GO:0000733)2.53796717
147maturation of 5.8S rRNA (GO:0000460)2.53548240
148leukocyte mediated cytotoxicity (GO:0001909)2.53467969
149positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.53322038
150macrophage activation (GO:0042116)2.53253240
151interferon-gamma-mediated signaling pathway (GO:0060333)2.52935414
152cell proliferation in forebrain (GO:0021846)2.52312483
153negative T cell selection (GO:0043383)2.52068264
154detection of other organism (GO:0098543)2.50161764
155regulation of nuclear cell cycle DNA replication (GO:0033262)2.49985702
156establishment of chromosome localization (GO:0051303)2.49055537
157regulation of MHC class II biosynthetic process (GO:0045346)2.48798933
158male meiosis I (GO:0007141)2.46910286
159postreplication repair (GO:0006301)2.46771752
160ubiquinone biosynthetic process (GO:0006744)2.45901408
161kinetochore assembly (GO:0051382)2.45641087
162regulation of mast cell activation (GO:0033003)2.45574702
163ncRNA catabolic process (GO:0034661)2.44852325
164myeloid leukocyte activation (GO:0002274)2.44815507
165negative thymic T cell selection (GO:0045060)2.43165933
166cellular response to interleukin-15 (GO:0071350)2.42427343
167RNA-dependent DNA replication (GO:0006278)2.41673725
168somatic recombination of immunoglobulin gene segments (GO:0016447)2.41206671
169tRNA processing (GO:0008033)2.41179574
170myeloid cell activation involved in immune response (GO:0002275)2.40758854
171positive regulation of interleukin-12 production (GO:0032735)2.40711485
172regulation of T cell migration (GO:2000404)2.40183218
173sequestering of actin monomers (GO:0042989)2.39628670
174defense response to protozoan (GO:0042832)2.39481348
175mitochondrial RNA metabolic process (GO:0000959)2.39295282
176neutrophil activation (GO:0042119)2.38399463
177reciprocal meiotic recombination (GO:0007131)2.38264825
178reciprocal DNA recombination (GO:0035825)2.38264825
179positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.38148069
180DNA ligation (GO:0006266)2.37611269
181DNA replication-dependent nucleosome organization (GO:0034723)2.35578157
182DNA replication-dependent nucleosome assembly (GO:0006335)2.35578157
183histone exchange (GO:0043486)2.34377190
184RNA phosphodiester bond hydrolysis (GO:0090501)2.33912232
185translesion synthesis (GO:0019985)2.33570081
186cellular ketone body metabolic process (GO:0046950)2.33449540
187protein-cofactor linkage (GO:0018065)2.33022127
188DNA catabolic process, exonucleolytic (GO:0000738)2.32409789
189mast cell activation involved in immune response (GO:0002279)2.32202671
190mast cell degranulation (GO:0043303)2.32202671
191somatic diversification of immune receptors (GO:0002200)2.30960965
192tRNA modification (GO:0006400)2.30565161
193regulation of rhodopsin mediated signaling pathway (GO:0022400)2.30486474
194gamma-aminobutyric acid transport (GO:0015812)2.30245598
195regulation of mesoderm development (GO:2000380)2.28978324

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human9.31848557
2IRF8_21731497_ChIP-ChIP_J774_Mouse4.38036360
3IRF8_22096565_ChIP-ChIP_GC-B_Human3.85462566
4FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.43310256
5IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.37728739
6ZNF274_21170338_ChIP-Seq_K562_Hela3.37060330
7E2F4_17652178_ChIP-ChIP_JURKAT_Human3.32730485
8VDR_22108803_ChIP-Seq_LS180_Human2.93555009
9E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.89829651
10SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.86048585
11BP1_19119308_ChIP-ChIP_Hs578T_Human2.77617332
12ELF1_17652178_ChIP-ChIP_JURKAT_Human2.76906681
13KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.69746687
14FOXM1_23109430_ChIP-Seq_U2OS_Human2.69505842
15FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.63093544
16IRF8_27001747_Chip-Seq_BMDM_Mouse2.60315312
17* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.58316742
18MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.42571382
19FLI1_27457419_Chip-Seq_LIVER_Mouse2.32573909
20GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.27397374
21EGR1_19374776_ChIP-ChIP_THP-1_Human2.22378592
22STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.17636656
23FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.15616449
24STAT4_19710469_ChIP-ChIP_TH1__Mouse2.06321173
25MYC_18555785_ChIP-Seq_MESCs_Mouse2.05489587
26SPI1_23547873_ChIP-Seq_NB4_Human2.04746715
27IRF1_19129219_ChIP-ChIP_H3396_Human2.03511510
28* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.02801507
29CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.01921256
30EST1_17652178_ChIP-ChIP_JURKAT_Human2.01529824
31IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.00576972
32EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.98658127
33EWS_26573619_Chip-Seq_HEK293_Human1.93837736
34* FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.92959203
35MYB_21317192_ChIP-Seq_ERMYB_Mouse1.91839510
36HOXB4_20404135_ChIP-ChIP_EML_Mouse1.91505724
37ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.89625367
38STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.87022728
39MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.86230566
40EZH2_22144423_ChIP-Seq_EOC_Human1.84609847
41GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.82905460
42E2F1_21310950_ChIP-Seq_MCF-7_Human1.77435239
43PCGF2_27294783_Chip-Seq_ESCs_Mouse1.76863371
44SCL_19346495_ChIP-Seq_HPC-7_Human1.74696818
45NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.74038910
46GATA1_22025678_ChIP-Seq_K562_Human1.69220632
47ELK1_19687146_ChIP-ChIP_HELA_Human1.68467384
48IGF1R_20145208_ChIP-Seq_DFB_Human1.66629981
49GABP_17652178_ChIP-ChIP_JURKAT_Human1.65759709
50* EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.65115863
51FUS_26573619_Chip-Seq_HEK293_Human1.64112368
52JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.60952389
53VDR_23849224_ChIP-Seq_CD4+_Human1.59636545
54SRF_21415370_ChIP-Seq_HL-1_Mouse1.58969428
55AR_21909140_ChIP-Seq_LNCAP_Human1.57984401
56RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.57283637
57SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.55043911
58MYB_26560356_Chip-Seq_TH2_Human1.53371283
59MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.51540673
60NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.49900461
61MYC_18358816_ChIP-ChIP_MESCs_Mouse1.49835962
62FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.49771436
63NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.48100223
64MYC_19030024_ChIP-ChIP_MESCs_Mouse1.48012708
65GBX2_23144817_ChIP-Seq_PC3_Human1.46227757
66TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.45685759
67ERG_20887958_ChIP-Seq_HPC-7_Mouse1.43746987
68NELFA_20434984_ChIP-Seq_ESCs_Mouse1.43427924
69BRD4_27068464_Chip-Seq_AML-cells_Mouse1.40893213
70RUNX1_22412390_ChIP-Seq_EML_Mouse1.39471196
71MYB_26560356_Chip-Seq_TH1_Human1.39260964
72CTBP1_25329375_ChIP-Seq_LNCAP_Human1.37774775
73FOXP3_21729870_ChIP-Seq_TREG_Human1.37490126
74ZFP57_27257070_Chip-Seq_ESCs_Mouse1.37218024
75PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.36440815
76HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.33950796
77NOTCH1_21737748_ChIP-Seq_TLL_Human1.33272367
78TP53_22573176_ChIP-Seq_HFKS_Human1.32187731
79NFE2_27457419_Chip-Seq_LIVER_Mouse1.31196639
80MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.30054550
81CREB1_15753290_ChIP-ChIP_HEK293T_Human1.29874282
82CTBP2_25329375_ChIP-Seq_LNCAP_Human1.27413352
83YY1_21170310_ChIP-Seq_MESCs_Mouse1.26866250
84ER_23166858_ChIP-Seq_MCF-7_Human1.25862655
85PCGF2_27294783_Chip-Seq_NPCs_Mouse1.24578709
86HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.23040871
87LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.22886993
88HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.22326577
89CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.21865356
90ETS1_20019798_ChIP-Seq_JURKAT_Human1.21701281
91LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.21041781
92CIITA_25753668_ChIP-Seq_RAJI_Human1.20698250
93MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.19176559
94SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.18069107
95GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.16476459
96MYC_19079543_ChIP-ChIP_MESCs_Mouse1.16441581
97SUZ12_27294783_Chip-Seq_NPCs_Mouse1.16068447
98GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.15351127
99PU_27001747_Chip-Seq_BMDM_Mouse1.15174750
100BMI1_23680149_ChIP-Seq_NPCS_Mouse1.14886608
101FOXA1_27270436_Chip-Seq_PROSTATE_Human1.14482341
102FOXA1_25329375_ChIP-Seq_VCAP_Human1.14482341
103POU3F2_20337985_ChIP-ChIP_501MEL_Human1.12914657
104DCP1A_22483619_ChIP-Seq_HELA_Human1.11284857
105* MAF_26560356_Chip-Seq_TH1_Human1.11282948
106RUNX_20019798_ChIP-Seq_JUKART_Human1.10839756
107VDR_24763502_ChIP-Seq_THP-1_Human1.09718337
108E2F1_18555785_ChIP-Seq_MESCs_Mouse1.09677628
109PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.09264150
110P300_19829295_ChIP-Seq_ESCs_Human1.09165430
111FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.05907530
112TAF15_26573619_Chip-Seq_HEK293_Human1.05382990
113IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.04149165
114CBP_20019798_ChIP-Seq_JUKART_Human1.04149165
115TTF2_22483619_ChIP-Seq_HELA_Human1.04134498
116EZH2_27294783_Chip-Seq_NPCs_Mouse1.02962214
117SALL1_21062744_ChIP-ChIP_HESCs_Human1.01660863
118EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.00937267
119NCOR_22424771_ChIP-Seq_293T_Human1.00902560
120VDR_21846776_ChIP-Seq_THP-1_Human1.00882993
121KDM5A_27292631_Chip-Seq_BREAST_Human1.00874107
122AUTS2_25519132_ChIP-Seq_293T-REX_Human1.00867274
123MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.00839747
124STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.00608295
125* EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.00202377
126GATA2_22383799_ChIP-Seq_G1ME_Mouse0.99909319
127GATA3_27048872_Chip-Seq_THYMUS_Human0.98878312
128XRN2_22483619_ChIP-Seq_HELA_Human0.97702258
129UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.97153158
130THAP11_20581084_ChIP-Seq_MESCs_Mouse0.93273838
131SOX2_19829295_ChIP-Seq_ESCs_Human0.93254706
132NANOG_19829295_ChIP-Seq_ESCs_Human0.93254706
133PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.93029670
134Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.92829764
135GATA3_26560356_Chip-Seq_TH1_Human0.92375969
136GATA3_21878914_ChIP-Seq_MCF-7_Human0.91283013
137* CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.90935983
138GATA1_22383799_ChIP-Seq_G1ME_Mouse0.90658033
139CRX_20693478_ChIP-Seq_RETINA_Mouse0.88342441
140HOXB7_26014856_ChIP-Seq_BT474_Human0.88207709
141POU5F1_16153702_ChIP-ChIP_HESCs_Human0.88028215
142POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.87747741
143TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.87747741
144TP63_19390658_ChIP-ChIP_HaCaT_Human0.87703898
145GABP_19822575_ChIP-Seq_HepG2_Human0.86609929
146GATA3_26560356_Chip-Seq_TH2_Human0.86332519
147SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.85766083
148CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.85706333
149PADI4_21655091_ChIP-ChIP_MCF-7_Human0.85110451
150ERA_21632823_ChIP-Seq_H3396_Human0.85078457
151* RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.85003980
152CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.84724150
153TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.84652175
154NANOG_20526341_ChIP-Seq_ESCs_Human0.84236359
155* CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.84021952
156AR_21572438_ChIP-Seq_LNCaP_Human0.82284984
157SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.81751035
158* CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.81744237
159MYC_18940864_ChIP-ChIP_HL60_Human0.80840076
160* GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.80666173
161YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.79861679
162MYC_22102868_ChIP-Seq_BL_Human0.79178006
163POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.79099149

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation5.52136273
2MP0002148_abnormal_hypersensitivity_rea2.95423076
3MP0002396_abnormal_hematopoietic_system2.90176258
4MP0008057_abnormal_DNA_replication2.85103388
5MP0004147_increased_porphyrin_level2.78420728
6MP0005671_abnormal_response_to2.68805709
7MP0009785_altered_susceptibility_to2.66025649
8MP0008007_abnormal_cellular_replicative2.53442086
9MP0003646_muscle_fatigue2.53311404
10MP0010094_abnormal_chromosome_stability2.49738042
11MP0002419_abnormal_innate_immunity2.32604684
12MP0002452_abnormal_antigen_presenting2.28030149
13MP0005025_abnormal_response_to2.27469253
14MP0006292_abnormal_olfactory_placode2.25094923
15MP0002163_abnormal_gland_morphology2.23851890
16MP0002166_altered_tumor_susceptibility2.21991985
17MP0005000_abnormal_immune_tolerance2.21190806
18MP0003436_decreased_susceptibility_to2.20467878
19MP0001800_abnormal_humoral_immune2.14408401
20MP0001819_abnormal_immune_cell2.11831916
21MP0002837_dystrophic_cardiac_calcinosis2.11199169
22MP0003724_increased_susceptibility_to2.09762360
23MP0003693_abnormal_embryo_hatching2.08323142
24MP0002420_abnormal_adaptive_immunity2.08004112
25MP0003763_abnormal_thymus_physiology2.06811492
26MP0003195_calcinosis2.03992361
27MP0002138_abnormal_hepatobiliary_system2.03422256
28MP0001790_abnormal_immune_system2.02896805
29MP0005387_immune_system_phenotype2.02896805
30MP0002723_abnormal_immune_serum1.99126276
31MP0000685_abnormal_immune_system1.98111780
32MP0009333_abnormal_splenocyte_physiolog1.97739392
33MP0006082_CNS_inflammation1.96018017
34MP0001853_heart_inflammation1.91256160
35MP0002006_tumorigenesis1.89963433
36MP0002398_abnormal_bone_marrow1.86877438
37MP0008058_abnormal_DNA_repair1.85483805
38MP0003111_abnormal_nucleus_morphology1.82569496
39MP0005464_abnormal_platelet_physiology1.80067134
40MP0003077_abnormal_cell_cycle1.79910142
41MP0008872_abnormal_physiological_respon1.75975645
42MP0006054_spinal_hemorrhage1.74215642
43MP0000490_abnormal_crypts_of1.72764512
44MP0005379_endocrine/exocrine_gland_phen1.68474902
45MP0005551_abnormal_eye_electrophysiolog1.68219744
46MP0000015_abnormal_ear_pigmentation1.67413252
47MP0002405_respiratory_system_inflammati1.67348680
48MP0000689_abnormal_spleen_morphology1.66505639
49MP0000716_abnormal_immune_system1.65865429
50MP0004142_abnormal_muscle_tone1.63768047
51MP0000569_abnormal_digit_pigmentation1.63564941
52MP0004782_abnormal_surfactant_physiolog1.62492813
53MP0002132_abnormal_respiratory_system1.59601029
54MP0004808_abnormal_hematopoietic_stem1.58075194
55MP0000343_altered_response_to1.57087293
56MP0001919_abnormal_reproductive_system1.55404137
57MP0005075_abnormal_melanosome_morpholog1.52929944
58MP0002009_preneoplasia1.52666281
59MP0002429_abnormal_blood_cell1.52463459
60MP0005174_abnormal_tail_pigmentation1.49623399
61MP0001968_abnormal_touch/_nociception1.48818499
62MP0005389_reproductive_system_phenotype1.48038666
63MP0002722_abnormal_immune_system1.47984084
64MP0001545_abnormal_hematopoietic_system1.47824003
65MP0005397_hematopoietic_system_phenotyp1.47824003
66MP0005645_abnormal_hypothalamus_physiol1.42833766
67MP0000631_abnormal_neuroendocrine_gland1.42390663
68MP0000858_altered_metastatic_potential1.42052474
69MP0010155_abnormal_intestine_physiology1.41771053
70MP0001529_abnormal_vocalization1.41306095
71MP0004742_abnormal_vestibular_system1.41239440
72MP0003787_abnormal_imprinting1.41094053
73MP0000465_gastrointestinal_hemorrhage1.40447154
74MP0003718_maternal_effect1.38445431
75MP0001485_abnormal_pinna_reflex1.38355968
76MP0005084_abnormal_gallbladder_morpholo1.36113046
77MP0004145_abnormal_muscle_electrophysio1.33926271
78MP0005410_abnormal_fertilization1.33288751
79MP0002638_abnormal_pupillary_reflex1.32700686
80MP0006072_abnormal_retinal_apoptosis1.31701226
81MP0001845_abnormal_inflammatory_respons1.27652487
82MP0002876_abnormal_thyroid_physiology1.27520922
83MP0002277_abnormal_respiratory_mucosa1.25673793
84MP0002102_abnormal_ear_morphology1.25160027
85MP0002736_abnormal_nociception_after1.24131546
86MP0005646_abnormal_pituitary_gland1.22415684
87MP0002160_abnormal_reproductive_system1.20947994
88MP0010307_abnormal_tumor_latency1.20109639
89MP0003186_abnormal_redox_activity1.19956773
90MP0004957_abnormal_blastocyst_morpholog1.19268182
91MP0003786_premature_aging1.16735967
92MP0001929_abnormal_gametogenesis1.16603578
93MP0009046_muscle_twitch1.16589663
94MP0002735_abnormal_chemical_nociception1.12280334
95MP0001873_stomach_inflammation1.12175873
96MP0002653_abnormal_ependyma_morphology1.11635824
97MP0009764_decreased_sensitivity_to1.11017574
98MP0005253_abnormal_eye_physiology1.10572786
99MP0002095_abnormal_skin_pigmentation1.10442003
100MP0009745_abnormal_behavioral_response1.10329751
101MP0003890_abnormal_embryonic-extraembry1.09929731
102MP0001533_abnormal_skeleton_physiology1.09841925
103MP0000703_abnormal_thymus_morphology1.09362525
104MP0002210_abnormal_sex_determination1.08966807
105MP0004885_abnormal_endolymph1.06499032
106MP0003136_yellow_coat_color1.06223926
107MP0003698_abnormal_male_reproductive1.05756287
108MP0006035_abnormal_mitochondrial_morpho1.05642866
109MP0004134_abnormal_chest_morphology1.03581763
110MP0008995_early_reproductive_senescence1.02952052
111MP0008469_abnormal_protein_level1.02170858
112MP0003943_abnormal_hepatobiliary_system1.01984822
113MP0001145_abnormal_male_reproductive1.01306959
114MP0002938_white_spotting0.99853586
115MP0004133_heterotaxia0.99171493
116MP0002693_abnormal_pancreas_physiology0.98265151
117MP0002019_abnormal_tumor_incidence0.96967455
118MP0003448_altered_tumor_morphology0.95018299
119MP0005058_abnormal_lysosome_morphology0.94396558
120MP0005220_abnormal_exocrine_pancreas0.93765161
121MP0000653_abnormal_sex_gland0.91414004
122MP0002272_abnormal_nervous_system0.90504043
123MP0002254_reproductive_system_inflammat0.88357117
124MP0009697_abnormal_copulation0.88114025
125MP0003191_abnormal_cellular_cholesterol0.88062707
126MP0003941_abnormal_skin_development0.83818421
127MP0008877_abnormal_DNA_methylation0.81325087
128MP0000313_abnormal_cell_death0.81215927
129MP0003279_aneurysm0.80981859
130MP0000049_abnormal_middle_ear0.79838589
131MP0002733_abnormal_thermal_nociception0.78919825
132MP0003828_pulmonary_edema0.78537116
133MP0001119_abnormal_female_reproductive0.78403705
134MP0000350_abnormal_cell_proliferation0.78089441
135MP0008875_abnormal_xenobiotic_pharmacok0.77803853
136MP0003567_abnormal_fetal_cardiomyocyte0.76867890
137MP0004924_abnormal_behavior0.76649003
138MP0005386_behavior/neurological_phenoty0.76649003
139MP0005409_darkened_coat_color0.76365415
140MP0005670_abnormal_white_adipose0.75538993
141MP0000371_diluted_coat_color0.75276756
142MP0003866_abnormal_defecation0.74614140
143MP0008932_abnormal_embryonic_tissue0.74396668
144MP0001186_pigmentation_phenotype0.73904499
145MP0000372_irregular_coat_pigmentation0.73157572
146MP0005310_abnormal_salivary_gland0.72927925
147MP0001915_intracranial_hemorrhage0.70867284
148MP0001764_abnormal_homeostasis0.69248064
149MP0003656_abnormal_erythrocyte_physiolo0.69083742
150MP0004883_abnormal_blood_vessel0.68355511
151MP0008438_abnormal_cutaneous_collagen0.66961172
152MP0005390_skeleton_phenotype0.66901508
153MP0004381_abnormal_hair_follicle0.65543272
154MP0002933_joint_inflammation0.64622179
155MP0009763_increased_sensitivity_to0.64514938
156MP0001986_abnormal_taste_sensitivity0.64207453
157MP0003172_abnormal_lysosome_physiology0.62901962
158MP0002075_abnormal_coat/hair_pigmentati0.62171003
159MP0001243_abnormal_dermal_layer0.61812873
160MP0005408_hypopigmentation0.61720537

Predicted human phenotypes

RankGene SetZ-score
1Recurrent abscess formation (HP:0002722)4.60249711
2Myositis (HP:0100614)4.23890879
3Optic neuritis (HP:0100653)4.17207431
4Retrobulbar optic neuritis (HP:0100654)4.17207431
5Recurrent bacterial skin infections (HP:0005406)4.03682969
6Orchitis (HP:0100796)3.93121244
7Chromsome breakage (HP:0040012)3.76026899
8Elevated erythrocyte sedimentation rate (HP:0003565)3.68851948
9Eczematoid dermatitis (HP:0000976)3.63398212
10Keratoconjunctivitis sicca (HP:0001097)3.61414128
11Chromosomal breakage induced by crosslinking agents (HP:0003221)3.53167627
12Thrombocytosis (HP:0001894)3.36867015
13Pendular nystagmus (HP:0012043)3.36381658
14Congenital stationary night blindness (HP:0007642)3.29699083
15Pancreatic cysts (HP:0001737)3.27764761
16Keratoconjunctivitis (HP:0001096)3.27178507
17Absent rod-and cone-mediated responses on ERG (HP:0007688)3.25911492
18Increased neuronal autofluorescent lipopigment (HP:0002074)3.16476461
19Systemic lupus erythematosus (HP:0002725)3.14612871
20Abnormal rod and cone electroretinograms (HP:0008323)3.02395355
21IgM deficiency (HP:0002850)3.01652669
22Cerebral palsy (HP:0100021)2.90142636
23Pancreatic fibrosis (HP:0100732)2.89770307
24Attenuation of retinal blood vessels (HP:0007843)2.89445064
25Spontaneous hematomas (HP:0007420)2.88914330
26Meningitis (HP:0001287)2.88528892
27Petechiae (HP:0000967)2.86135412
28Chronic otitis media (HP:0000389)2.85507833
29Abnormality of the prostate (HP:0008775)2.83485505
30Abolished electroretinogram (ERG) (HP:0000550)2.83218809
31Abnormality of midbrain morphology (HP:0002418)2.82616320
32Molar tooth sign on MRI (HP:0002419)2.82616320
33Obstructive lung disease (HP:0006536)2.81681918
34Chronic obstructive pulmonary disease (HP:0006510)2.81681918
35Spinal cord lesions (HP:0100561)2.78422669
36Syringomyelia (HP:0003396)2.78422669
37Hypoplasia of the pons (HP:0012110)2.74642176
38Abnormality of the anterior horn cell (HP:0006802)2.72937115
39Degeneration of anterior horn cells (HP:0002398)2.72937115
40Chronic hepatic failure (HP:0100626)2.70994845
41Birth length less than 3rd percentile (HP:0003561)2.67881314
42True hermaphroditism (HP:0010459)2.67113605
43Nephronophthisis (HP:0000090)2.65063989
44Abnormality of the pons (HP:0007361)2.62801709
45Agnosia (HP:0010524)2.61521058
46Encephalitis (HP:0002383)2.60400760
47Type II lissencephaly (HP:0007260)2.57463615
48Recurrent viral infections (HP:0004429)2.54051580
49Glomerulopathy (HP:0100820)2.51392606
50Increased cerebral lipofuscin (HP:0011813)2.50051512
51Abnormality of the pleura (HP:0002103)2.49522850
52Abnormality of the heme biosynthetic pathway (HP:0010472)2.46954088
53Reticulocytopenia (HP:0001896)2.46032597
54Mediastinal lymphadenopathy (HP:0100721)2.44482196
55Genetic anticipation (HP:0003743)2.44404287
56Methylmalonic acidemia (HP:0002912)2.43481127
57Clubbing of toes (HP:0100760)2.41028202
58Panhypogammaglobulinemia (HP:0003139)2.38155812
59Vasculitis (HP:0002633)2.37892577
60Glomerulonephritis (HP:0000099)2.36131134
61Periodontitis (HP:0000704)2.34911066
6211 pairs of ribs (HP:0000878)2.33587697
63Recurrent skin infections (HP:0001581)2.33343920
64Abnormality of complement system (HP:0005339)2.31608938
65Pulmonary infiltrates (HP:0002113)2.30232211
66Recurrent pneumonia (HP:0006532)2.30187699
67Aplasia/Hypoplasia of the uvula (HP:0010293)2.30079202
68Reduced antithrombin III activity (HP:0001976)2.29490944
69Abnormality of T cell physiology (HP:0011840)2.28732878
70Lipid accumulation in hepatocytes (HP:0006561)2.26322237
71Agammaglobulinemia (HP:0004432)2.26306700
72Severe visual impairment (HP:0001141)2.25611274
73Progressive inability to walk (HP:0002505)2.24117884
74Abnormal delayed hypersensitivity skin test (HP:0002963)2.23557882
75Bony spicule pigmentary retinopathy (HP:0007737)2.23300164
76Aplastic anemia (HP:0001915)2.23111394
77Asplenia (HP:0001746)2.22804267
78Type I transferrin isoform profile (HP:0003642)2.22330845
793-Methylglutaconic aciduria (HP:0003535)2.22323972
80Methylmalonic aciduria (HP:0012120)2.22137275
81Amaurosis fugax (HP:0100576)2.21878801
82Aplasia/Hypoplasia of the spleen (HP:0010451)2.20082709
83Pulmonary fibrosis (HP:0002206)2.18389793
84Increased CSF lactate (HP:0002490)2.18226894
85Decreased electroretinogram (ERG) amplitude (HP:0000654)2.18171166
86Increased hepatocellular lipid droplets (HP:0006565)2.17935555
87Mitochondrial inheritance (HP:0001427)2.17101047
88Decreased central vision (HP:0007663)2.16534408
89Cellulitis (HP:0100658)2.15885955
90Ectopic kidney (HP:0000086)2.14844539
91Arterial thrombosis (HP:0004420)2.14453792
92Abnormality of DNA repair (HP:0003254)2.14098450
93Abnormality of the ileum (HP:0001549)2.13543540
94Recurrent fungal infections (HP:0002841)2.13307716
95Abnormality of the renal medulla (HP:0100957)2.13016970
96Osteomyelitis (HP:0002754)2.12369931
97Granulocytopenia (HP:0001913)2.12080576
98Prostate neoplasm (HP:0100787)2.11767944
99Abnormality of chromosome stability (HP:0003220)2.11752618
100Keratoconus (HP:0000563)2.10754666
101Increased corneal curvature (HP:0100692)2.10754666
102Acute necrotizing encephalopathy (HP:0006965)2.08816639
103Inability to walk (HP:0002540)2.07496758
104Eosinophilia (HP:0001880)2.07241305
105Aplasia/Hypoplasia of the patella (HP:0006498)2.06637800
106Cleft eyelid (HP:0000625)2.05645712
107Abnormality of homocysteine metabolism (HP:0010919)2.05600706
108Homocystinuria (HP:0002156)2.05600706
109Lymphoma (HP:0002665)2.05219223
110Keratitis (HP:0000491)2.02681181
111Recurrent gram-negative bacterial infections (HP:0005420)2.02410065
112Patellar aplasia (HP:0006443)2.02347919
113Hemoptysis (HP:0002105)2.02021008
114Sclerocornea (HP:0000647)2.01569388
115Duplicated collecting system (HP:0000081)2.01141096
116Autoimmune thrombocytopenia (HP:0001973)2.00403892
117Myelodysplasia (HP:0002863)1.99006834
118Gaze-evoked nystagmus (HP:0000640)1.97896917
119Abnormality of T cells (HP:0002843)1.97115178
120Abnormal spermatogenesis (HP:0008669)1.95213911
121Long clavicles (HP:0000890)1.94867439
122Recurrent lower respiratory tract infections (HP:0002783)1.94621826
123Abnormality of the renal cortex (HP:0011035)1.94593992
124Abnormality of macrophages (HP:0004311)1.93712629
125Abnormal number of erythroid precursors (HP:0012131)1.93263317
126Skin rash (HP:0000988)1.93183286
127Abnormal mitochondria in muscle tissue (HP:0008316)1.92862408
128Abnormality of the preputium (HP:0100587)1.92537599
129Progressive cerebellar ataxia (HP:0002073)1.92293576
130IgA deficiency (HP:0002720)1.90772717
131Prolonged bleeding time (HP:0003010)1.90760298
132Azoospermia (HP:0000027)1.90523598
133Hepatocellular necrosis (HP:0001404)1.90375701
134Pustule (HP:0200039)1.89478951
135Congenital, generalized hypertrichosis (HP:0004540)1.89186106
136Increased serum lactate (HP:0002151)1.88472583
137Hepatosplenomegaly (HP:0001433)1.87494284
138Exertional dyspnea (HP:0002875)1.87483142
139Vacuolated lymphocytes (HP:0001922)1.85688756
140Agitation (HP:0000713)1.85580059
141Nonimmune hydrops fetalis (HP:0001790)1.85342207
142Carpal bone hypoplasia (HP:0001498)1.84990804
143Osteolytic defects of the phalanges of the hand (HP:0009771)1.84333325
144Osteolytic defects of the hand bones (HP:0009699)1.84333325
145Meckel diverticulum (HP:0002245)1.83198205
146Progressive macrocephaly (HP:0004481)1.83007060
147Acute encephalopathy (HP:0006846)1.82842987
148Leukocytosis (HP:0001974)1.82571028
149B lymphocytopenia (HP:0010976)1.82213508
150Abnormality of B cell number (HP:0010975)1.82213508
151Recurrent cutaneous fungal infections (HP:0011370)1.81926093
152Chronic mucocutaneous candidiasis (HP:0002728)1.81926093
153Poor head control (HP:0002421)1.81216092
154Combined immunodeficiency (HP:0005387)1.80699943
155Basal ganglia calcification (HP:0002135)1.80456960
156Nephritis (HP:0000123)1.80059033
157IgG deficiency (HP:0004315)1.79923166
158Absent thumb (HP:0009777)1.79872209
159Stomatitis (HP:0010280)1.79051940
160Severe combined immunodeficiency (HP:0004430)1.77903317
161Gangrene (HP:0100758)1.77368327
162Acute myeloid leukemia (HP:0004808)1.76783523
163Cystic liver disease (HP:0006706)1.75300914
164Abnormality of the labia minora (HP:0012880)1.71349737
165Polydipsia (HP:0001959)1.70442119
166Abnormal drinking behavior (HP:0030082)1.70442119
167Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.67389506
168Optic nerve hypoplasia (HP:0000609)1.67277689
169Abnormality of the middle phalanx of the 5th finger (HP:0004219)1.66869278
170Sloping forehead (HP:0000340)1.66864609
171Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.66821366
172Thyroiditis (HP:0100646)1.64872416
173Anencephaly (HP:0002323)1.63417057
174Neoplasm of the adrenal cortex (HP:0100641)1.63412996
175Optic disc pallor (HP:0000543)1.63195296
176Hypothermia (HP:0002045)1.62856657
177Constricted visual fields (HP:0001133)1.62172319
178Aplasia/hypoplasia of the uterus (HP:0008684)1.61598082
179Lissencephaly (HP:0001339)1.61067439
180Abnormality of the vitamin B12 metabolism (HP:0004341)1.59848382
181Abnormality of vitamin B metabolism (HP:0004340)1.59838318
182Retinal dysplasia (HP:0007973)1.59781803
183Colon cancer (HP:0003003)1.59716435

Predicted kinase interactions (KEA)

RankGene SetZ-score
1IRAK43.73208620
2MAP4K13.12725257
3MAP3K142.83349478
4TXK2.74299834
5TEC2.74015642
6CLK12.51177979
7BRSK22.46212741
8WNK32.45435562
9EIF2AK12.28241954
10BLK1.92829318
11ZAK1.90083916
12NEK91.87157555
13TYK21.85301367
14KIT1.85301074
15CSF1R1.82122542
16MAP4K21.79233094
17VRK21.77840124
18EIF2AK21.77204713
19TAF11.77203969
20BTK1.72989404
21TIE11.66712954
22CDC71.65270839
23MKNK11.62006876
24ZAP701.58452586
25STK161.55654717
26INSRR1.54666076
27CAMKK21.52235767
28PIM21.51256813
29PLK41.50275899
30ACVR1B1.46750092
31VRK11.45881447
32STK101.45345738
33IKBKB1.44886670
34SRPK11.44072583
35BUB11.43887408
36IRAK31.41048331
37TGFBR21.40234511
38WNK41.39475061
39TRPM71.36682976
40SYK1.35035158
41ITK1.34397694
42JAK31.33466787
43IKBKE1.30699224
44YES11.29080096
45MAP2K31.27740378
46BCKDK1.25942321
47DYRK21.25067059
48PINK11.24572860
49PIM11.23580450
50TBK11.19168547
51BMPR21.16018733
52TNIK1.14049092
53BRSK11.14048869
54PRKCQ1.11891628
55MKNK21.08415624
56ATR1.08110719
57NME21.07091076
58LYN1.05608194
59GRK11.05014815
60STK41.04423746
61TSSK61.03892283
62ERBB31.03847655
63MAPK131.03719924
64TGFBR11.02223467
65PLK31.02169997
66FLT31.01807512
67NLK0.99573820
68MAPKAPK50.98674842
69WEE10.97638800
70CHUK0.97226384
71NUAK10.96824040
72MST40.95645149
73STK240.93921772
74CDK80.90991139
75GRK70.86854700
76JAK10.79483183
77HCK0.78924986
78NEK10.78853445
79PRKCH0.78655994
80BMPR1B0.77077678
81PLK10.75315565
82EIF2AK30.74778219
83OXSR10.74456769
84CDK40.72329570
85AURKB0.71712842
86LCK0.71154399
87ADRBK20.70540297
88NEK60.69517028
89TAOK20.69114015
90SIK20.68633393
91GRK60.67564676
92RPS6KA60.67277599
93MAP3K40.66435985
94PASK0.65644899
95PRKCG0.64882857
96MAP3K30.64551385
97RPS6KC10.63612778
98RPS6KL10.63612778
99CCNB10.62015875
100SGK20.61934153
101RPS6KA40.61108718
102MAP3K120.60835271
103TRIM280.60308082
104TAOK30.60249123
105PLK20.59994115
106MAPKAPK30.59342375
107FRK0.59110205
108ATM0.58649152
109IRAK10.58263025
110ADRBK10.57963768
111TLK10.57226653
112RPS6KA50.57203057
113NEK20.56166574
114CSK0.54534970
115MAP3K80.54336770
116CDK70.54273978
117TTK0.53910388
118STK110.53142307
119PIK3CG0.52377576
120CAMKK10.51200261
121CASK0.51043920
122MAP2K60.50263406
123CHEK10.49882952
124MAPKAPK20.49092425
125NME10.48504774
126MYLK0.48056350
127PRKCD0.47677524
128CSNK2A10.47296778
129MAP3K90.45644830
130PNCK0.45456084
131PRPF4B0.45249011
132CAMK1D0.44905664
133MAPK110.44745966
134STK390.43599422
135CDK60.43197628
136MARK30.43056407
137FGFR30.42076307
138KDR0.41854248
139RPS6KB10.40809454
140MATK0.40807301
141CHEK20.40040597
142PAK30.38387267
143FGFR20.37166164
144CSNK1G10.36973046
145CSNK1A10.36768630
146IGF1R0.34416094
147PRKCI0.34154417
148CSNK2A20.33506898
149PKN10.31238903

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.26850904
2Mismatch repair_Homo sapiens_hsa034303.59254879
3Base excision repair_Homo sapiens_hsa034102.93350170
4Homologous recombination_Homo sapiens_hsa034402.62751750
5Non-homologous end-joining_Homo sapiens_hsa034502.18075971
6Proteasome_Homo sapiens_hsa030502.11770224
7Intestinal immune network for IgA production_Homo sapiens_hsa046722.11160874
8Nucleotide excision repair_Homo sapiens_hsa034202.05420032
9Phototransduction_Homo sapiens_hsa047442.04375224
10Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.03550260
11Primary immunodeficiency_Homo sapiens_hsa053402.01425819
12Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.01310792
13Antigen processing and presentation_Homo sapiens_hsa046121.99134297
14Leishmaniasis_Homo sapiens_hsa051401.91583762
15Fanconi anemia pathway_Homo sapiens_hsa034601.88517032
16One carbon pool by folate_Homo sapiens_hsa006701.84761636
17Selenocompound metabolism_Homo sapiens_hsa004501.80582747
18RNA polymerase_Homo sapiens_hsa030201.80427027
19Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.79468447
20Measles_Homo sapiens_hsa051621.76236405
21Allograft rejection_Homo sapiens_hsa053301.75825555
22Cell cycle_Homo sapiens_hsa041101.72648848
23Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.67918252
24Ribosome_Homo sapiens_hsa030101.67235709
25Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.63016215
26Staphylococcus aureus infection_Homo sapiens_hsa051501.61843138
27Pyrimidine metabolism_Homo sapiens_hsa002401.60282686
28NF-kappa B signaling pathway_Homo sapiens_hsa040641.59009211
29Oxidative phosphorylation_Homo sapiens_hsa001901.58642118
30Herpes simplex infection_Homo sapiens_hsa051681.57658601
31Spliceosome_Homo sapiens_hsa030401.53380357
32Graft-versus-host disease_Homo sapiens_hsa053321.53043201
33Legionellosis_Homo sapiens_hsa051341.48813536
34Parkinsons disease_Homo sapiens_hsa050121.47925024
35Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.46197515
36Pertussis_Homo sapiens_hsa051331.44922445
37Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.39107470
38Toll-like receptor signaling pathway_Homo sapiens_hsa046201.38288320
39Linoleic acid metabolism_Homo sapiens_hsa005911.37660793
40Influenza A_Homo sapiens_hsa051641.34065259
41Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.30667570
42Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.30362740
43RNA degradation_Homo sapiens_hsa030181.29885040
44alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.28862269
45p53 signaling pathway_Homo sapiens_hsa041151.24163235
46Butanoate metabolism_Homo sapiens_hsa006501.23142432
47RNA transport_Homo sapiens_hsa030131.22405344
48Viral myocarditis_Homo sapiens_hsa054161.21843775
49Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.21472387
50Glycosaminoglycan degradation_Homo sapiens_hsa005311.15609300
51Maturity onset diabetes of the young_Homo sapiens_hsa049501.15173557
52Hematopoietic cell lineage_Homo sapiens_hsa046401.14384761
53Other glycan degradation_Homo sapiens_hsa005111.13273725
54Nitrogen metabolism_Homo sapiens_hsa009101.10722477
55Nicotine addiction_Homo sapiens_hsa050331.10172589
56Autoimmune thyroid disease_Homo sapiens_hsa053201.08239184
57Osteoclast differentiation_Homo sapiens_hsa043801.07979922
58Arachidonic acid metabolism_Homo sapiens_hsa005901.06717751
59Basal transcription factors_Homo sapiens_hsa030221.06255713
60Toxoplasmosis_Homo sapiens_hsa051451.05091989
61Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.04226888
62Olfactory transduction_Homo sapiens_hsa047401.02046205
63Huntingtons disease_Homo sapiens_hsa050161.01362291
64RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.01210327
65Malaria_Homo sapiens_hsa051440.99939177
66Apoptosis_Homo sapiens_hsa042100.97601442
67NOD-like receptor signaling pathway_Homo sapiens_hsa046210.97388968
68Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.95648742
69Epstein-Barr virus infection_Homo sapiens_hsa051690.94791615
70B cell receptor signaling pathway_Homo sapiens_hsa046620.94675398
71Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.94568376
72Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.94147675
73Tuberculosis_Homo sapiens_hsa051520.91171583
74Purine metabolism_Homo sapiens_hsa002300.89916187
75Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.89545560
76Jak-STAT signaling pathway_Homo sapiens_hsa046300.88131116
77Tryptophan metabolism_Homo sapiens_hsa003800.84814395
78Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.83486471
79Taste transduction_Homo sapiens_hsa047420.80800595
80Hepatitis B_Homo sapiens_hsa051610.78534160
81Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.77832986
82Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.77684190
83Systemic lupus erythematosus_Homo sapiens_hsa053220.77385433
84Lysosome_Homo sapiens_hsa041420.77178166
85Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.75594513
86Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.73869564
87Transcriptional misregulation in cancer_Homo sapiens_hsa052020.73073401
88Ether lipid metabolism_Homo sapiens_hsa005650.72497610
89Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.72350018
90Propanoate metabolism_Homo sapiens_hsa006400.70972350
91Protein export_Homo sapiens_hsa030600.70932818
92Salmonella infection_Homo sapiens_hsa051320.70558648
93Shigellosis_Homo sapiens_hsa051310.69279682
94Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.68729061
95Glycerolipid metabolism_Homo sapiens_hsa005610.68538781
96Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.67299334
97Asthma_Homo sapiens_hsa053100.66415360
98Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.65758208
99Caffeine metabolism_Homo sapiens_hsa002320.64008027
100Viral carcinogenesis_Homo sapiens_hsa052030.63677609
101Alzheimers disease_Homo sapiens_hsa050100.62584891
102Leukocyte transendothelial migration_Homo sapiens_hsa046700.61814426
103Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.60544710
104HTLV-I infection_Homo sapiens_hsa051660.54920386
105Morphine addiction_Homo sapiens_hsa050320.54347839
106T cell receptor signaling pathway_Homo sapiens_hsa046600.52547765
107Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.52508606
108Phagosome_Homo sapiens_hsa041450.52174017
109Chemokine signaling pathway_Homo sapiens_hsa040620.49674339
110Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.48247936
111mRNA surveillance pathway_Homo sapiens_hsa030150.46696334
112Hepatitis C_Homo sapiens_hsa051600.46041354
113Peroxisome_Homo sapiens_hsa041460.45787985
114N-Glycan biosynthesis_Homo sapiens_hsa005100.45220342
115Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.44934198
116Drug metabolism - other enzymes_Homo sapiens_hsa009830.40911677
117Cardiac muscle contraction_Homo sapiens_hsa042600.40910612
118Cysteine and methionine metabolism_Homo sapiens_hsa002700.40784340
119Metabolic pathways_Homo sapiens_hsa011000.39906189
120SNARE interactions in vesicular transport_Homo sapiens_hsa041300.39818955
121Type I diabetes mellitus_Homo sapiens_hsa049400.38344212
122Fatty acid elongation_Homo sapiens_hsa000620.38311465
123Rheumatoid arthritis_Homo sapiens_hsa053230.37246487
124Thyroid cancer_Homo sapiens_hsa052160.37144336
125Sulfur relay system_Homo sapiens_hsa041220.37011065
126Notch signaling pathway_Homo sapiens_hsa043300.36618421
127Small cell lung cancer_Homo sapiens_hsa052220.36279462
128TNF signaling pathway_Homo sapiens_hsa046680.34905517
129Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.34270305
130Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.33545203
131Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.33492933
132Fat digestion and absorption_Homo sapiens_hsa049750.33236621
133Serotonergic synapse_Homo sapiens_hsa047260.32979410
134Complement and coagulation cascades_Homo sapiens_hsa046100.32811587
135Vitamin digestion and absorption_Homo sapiens_hsa049770.32445753
136Platelet activation_Homo sapiens_hsa046110.31668363
137Regulation of autophagy_Homo sapiens_hsa041400.30429082
138Chemical carcinogenesis_Homo sapiens_hsa052040.29023410
139MicroRNAs in cancer_Homo sapiens_hsa052060.28660936
140Cyanoamino acid metabolism_Homo sapiens_hsa004600.27362353
141Pancreatic cancer_Homo sapiens_hsa052120.26615963
142Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.26564138
143ABC transporters_Homo sapiens_hsa020100.26161208
144Calcium signaling pathway_Homo sapiens_hsa040200.25597163
145Acute myeloid leukemia_Homo sapiens_hsa052210.24681636
146Melanoma_Homo sapiens_hsa052180.21937471
147Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.21077810

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