ITSN1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a cytoplasmic membrane-associated protein that indirectly coordinates endocytic membrane traffic with the actin assembly machinery. In addition, the encoded protein may regulate the formation of clathrin-coated vesicles and could be involved in synaptic vesicle recycling. This protein has been shown to interact with dynamin, CDC42, SNAP23, SNAP25, SPIN90, EPS15, EPN1, EPN2, and STN2. Multiple transcript variants encoding different isoforms have been found for this gene, but the full-length nature of only two of them have been characterized so far. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of short-term neuronal synaptic plasticity (GO:0048172)5.37092737
2synaptic vesicle maturation (GO:0016188)5.28961186
3locomotory exploration behavior (GO:0035641)5.23234605
4vocalization behavior (GO:0071625)4.92923238
5positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.83507149
6layer formation in cerebral cortex (GO:0021819)4.82328142
7regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.78162677
8positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.72195665
9regulation of glutamate receptor signaling pathway (GO:1900449)4.40303573
10synaptic vesicle docking involved in exocytosis (GO:0016081)4.36354062
11ionotropic glutamate receptor signaling pathway (GO:0035235)4.24643279
12regulation of synapse structural plasticity (GO:0051823)4.22194526
13synaptic vesicle exocytosis (GO:0016079)4.11651261
14exploration behavior (GO:0035640)4.06346434
15protein localization to synapse (GO:0035418)4.02901349
16presynaptic membrane assembly (GO:0097105)4.02042123
17positive regulation of synapse maturation (GO:0090129)3.96964797
18glutamate secretion (GO:0014047)3.91196465
19sodium ion export (GO:0071436)3.90732847
20dendrite morphogenesis (GO:0048813)3.84686911
21regulation of synaptic vesicle exocytosis (GO:2000300)3.80109695
22dendritic spine morphogenesis (GO:0060997)3.79101213
23presynaptic membrane organization (GO:0097090)3.78144012
24gamma-aminobutyric acid transport (GO:0015812)3.76253684
25neuron cell-cell adhesion (GO:0007158)3.68837725
26cell migration in hindbrain (GO:0021535)3.67474341
27axonal fasciculation (GO:0007413)3.67040346
28regulation of neuronal synaptic plasticity (GO:0048168)3.63412184
29glutamate receptor signaling pathway (GO:0007215)3.61339926
30neurotransmitter secretion (GO:0007269)3.60677037
31cerebellar Purkinje cell differentiation (GO:0021702)3.60609138
32neurotransmitter-gated ion channel clustering (GO:0072578)3.58931811
33cell communication by electrical coupling (GO:0010644)3.58309466
34regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.56587744
35establishment of mitochondrion localization (GO:0051654)3.54003955
36synaptic transmission, glutamatergic (GO:0035249)3.52706746
37regulation of long-term neuronal synaptic plasticity (GO:0048169)3.48966093
38proline transport (GO:0015824)3.48522185
39cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.47556946
40establishment of nucleus localization (GO:0040023)3.41555285
41neuron recognition (GO:0008038)3.40026735
42regulation of synaptic vesicle transport (GO:1902803)3.38692170
43cellular potassium ion homeostasis (GO:0030007)3.37205126
44neuromuscular process controlling balance (GO:0050885)3.35041977
45response to pheromone (GO:0019236)3.31951021
46membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.27932876
47regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.22922172
48central nervous system projection neuron axonogenesis (GO:0021952)3.21204732
49activation of protein kinase A activity (GO:0034199)3.15869502
50establishment of mitochondrion localization, microtubule-mediated (GO:0034643)3.15139606
51mitochondrion transport along microtubule (GO:0047497)3.15139606
52regulation of excitatory postsynaptic membrane potential (GO:0060079)3.13983933
53L-amino acid import (GO:0043092)3.13767471
54regulation of synapse maturation (GO:0090128)3.09212135
55postsynaptic membrane organization (GO:0001941)3.07080364
56regulation of ARF protein signal transduction (GO:0032012)3.05534603
57neuron-neuron synaptic transmission (GO:0007270)3.04982998
58* synaptic vesicle endocytosis (GO:0048488)3.02819930
59long-term memory (GO:0007616)3.02169378
60regulation of postsynaptic membrane potential (GO:0060078)3.02152244
61cerebellar Purkinje cell layer development (GO:0021680)3.01971321
62positive regulation of membrane potential (GO:0045838)2.97798688
63clathrin coat assembly (GO:0048268)2.97533379
64regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.94417124
65cerebellar granule cell differentiation (GO:0021707)2.93405564
66regulation of dendritic spine morphogenesis (GO:0061001)2.92080165
67auditory behavior (GO:0031223)2.90217238
68positive regulation of dendritic spine development (GO:0060999)2.86862941
69response to auditory stimulus (GO:0010996)2.85614719
70positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.85414507
71regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.84014403
72membrane depolarization during action potential (GO:0086010)2.83217694
73cytoskeletal anchoring at plasma membrane (GO:0007016)2.82895367
74neuronal action potential propagation (GO:0019227)2.82231722
75axon extension (GO:0048675)2.81173143
76vesicle transport along microtubule (GO:0047496)2.81137290
77positive regulation of dendritic spine morphogenesis (GO:0061003)2.80529913
78positive regulation of synapse assembly (GO:0051965)2.79851054
79paraxial mesoderm development (GO:0048339)2.78698522
80neurotransmitter transport (GO:0006836)2.78138417
81spinal cord development (GO:0021510)2.77541768
82G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.77418241
83nucleobase catabolic process (GO:0046113)2.74844307
84positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.74751215
85glycine transport (GO:0015816)2.73726567
86neuronal ion channel clustering (GO:0045161)2.73274646
87neuromuscular process (GO:0050905)2.72068894
88positive regulation of fibroblast migration (GO:0010763)2.70710404
89positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.70481030
90regulation of synaptic plasticity (GO:0048167)2.70029360
91organelle transport along microtubule (GO:0072384)2.69567027
92regulation of clathrin-mediated endocytosis (GO:2000369)2.69431339
93regulation of neurotransmitter secretion (GO:0046928)2.69205204
94prepulse inhibition (GO:0060134)2.68833475
95startle response (GO:0001964)2.68623249
96regulation of synaptic transmission, glutamatergic (GO:0051966)2.68354329
97pyrimidine nucleobase catabolic process (GO:0006208)2.67209353
98synapse assembly (GO:0007416)2.63895052
99intraspecies interaction between organisms (GO:0051703)2.63587152
100social behavior (GO:0035176)2.63587152
101innervation (GO:0060384)2.63540174
102negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.62224379
103positive regulation of axon extension (GO:0045773)2.62034502
104membrane depolarization (GO:0051899)2.61871873
105cell differentiation in hindbrain (GO:0021533)2.61538497
106neuromuscular process controlling posture (GO:0050884)2.61169025
107positive regulation of synaptic transmission, GABAergic (GO:0032230)2.60975485
108regulation of dendritic spine development (GO:0060998)2.59469123
109regulation of neurotransmitter levels (GO:0001505)2.58845657
110axon extension involved in axon guidance (GO:0048846)2.56680679
111neuron projection extension involved in neuron projection guidance (GO:1902284)2.56680679
112alanine transport (GO:0032328)2.56413732
113regulation of axon extension involved in axon guidance (GO:0048841)2.55594088
114cerebral cortex radially oriented cell migration (GO:0021799)2.54295156
115regulation of axon guidance (GO:1902667)2.53659531
116retinal ganglion cell axon guidance (GO:0031290)2.46143386
117negative regulation of synaptic transmission, GABAergic (GO:0032229)2.41574079
118neuron projection extension (GO:1990138)2.39247538
119regulation of synapse assembly (GO:0051963)2.39026030
120peripheral nervous system axon ensheathment (GO:0032292)2.37737195
121myelination in peripheral nervous system (GO:0022011)2.37737195
122synapse organization (GO:0050808)2.36623341
123calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)2.35838538
124lateral sprouting from an epithelium (GO:0060601)2.34308251
125transmission of nerve impulse (GO:0019226)2.33740775
126central nervous system neuron axonogenesis (GO:0021955)2.33178506
127negative regulation of cytosolic calcium ion concentration (GO:0051481)2.29061158
128adult walking behavior (GO:0007628)2.29006172
129behavioral response to nicotine (GO:0035095)2.28868623
130apical protein localization (GO:0045176)2.27946682
131ephrin receptor signaling pathway (GO:0048013)2.26555075
132camera-type eye morphogenesis (GO:0048593)2.25997585
133mechanosensory behavior (GO:0007638)2.25540509
134dendrite development (GO:0016358)2.24071038
135suckling behavior (GO:0001967)2.23946738
136negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.23213853
137neuromuscular synaptic transmission (GO:0007274)2.21658101
138axon cargo transport (GO:0008088)2.21155260
139nonmotile primary cilium assembly (GO:0035058)2.20606987
140neuron migration (GO:0001764)2.20045435
141membrane assembly (GO:0071709)2.19911474
142limb bud formation (GO:0060174)2.18363802
143regulation of gene silencing by RNA (GO:0060966)2.18119823
144regulation of posttranscriptional gene silencing (GO:0060147)2.18119823
145regulation of gene silencing by miRNA (GO:0060964)2.18119823
146neuronal stem cell maintenance (GO:0097150)2.15262412
147appendage development (GO:0048736)2.14544066
148limb development (GO:0060173)2.14544066
149neurofilament cytoskeleton organization (GO:0060052)2.13516954

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.05897990
2GBX2_23144817_ChIP-Seq_PC3_Human2.78825346
3JARID2_20064375_ChIP-Seq_MESCs_Mouse2.67574108
4DROSHA_22980978_ChIP-Seq_HELA_Human2.64998297
5SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.64397194
6SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.60203192
7RNF2_18974828_ChIP-Seq_MESCs_Mouse2.55328679
8EZH2_18974828_ChIP-Seq_MESCs_Mouse2.55328679
9EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.51012408
10JARID2_20075857_ChIP-Seq_MESCs_Mouse2.29268872
11SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.27891830
12ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.24943087
13MTF2_20144788_ChIP-Seq_MESCs_Mouse2.23409368
14REST_21632747_ChIP-Seq_MESCs_Mouse2.20749738
15SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.17945395
16* RARB_27405468_Chip-Seq_BRAIN_Mouse2.17707419
17SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.17058211
18EZH2_27304074_Chip-Seq_ESCs_Mouse2.16849890
19CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.14116845
20SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.12492912
21ZFP57_27257070_Chip-Seq_ESCs_Mouse2.09457862
22RNF2_27304074_Chip-Seq_ESCs_Mouse2.08586140
23EZH2_27294783_Chip-Seq_ESCs_Mouse2.08206273
24EED_16625203_ChIP-ChIP_MESCs_Mouse2.01938467
25TAF15_26573619_Chip-Seq_HEK293_Human1.98545468
26MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.95746119
27SUZ12_27294783_Chip-Seq_ESCs_Mouse1.92916330
28NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.92064191
29RBPJ_22232070_ChIP-Seq_NCS_Mouse1.91222015
30IKZF1_21737484_ChIP-ChIP_HCT116_Human1.84094951
31* REST_18959480_ChIP-ChIP_MESCs_Mouse1.75200783
32GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.72706100
33HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.67080010
34KDM2B_26808549_Chip-Seq_K562_Human1.63899275
35SALL1_21062744_ChIP-ChIP_HESCs_Human1.63545881
36ZFP281_18757296_ChIP-ChIP_E14_Mouse1.60852526
37TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.60073581
38RNF2_27304074_Chip-Seq_NSC_Mouse1.59633718
39P300_19829295_ChIP-Seq_ESCs_Human1.57393036
40WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.56749439
41ERG_21242973_ChIP-ChIP_JURKAT_Human1.56598245
42* SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.55327786
43SMAD_19615063_ChIP-ChIP_OVARY_Human1.54384624
44SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.49003163
45AR_21572438_ChIP-Seq_LNCaP_Human1.45887306
46TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.44053818
47TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.42487251
48SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.41322225
49GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.40483490
50FUS_26573619_Chip-Seq_HEK293_Human1.40020425
51ZFP281_27345836_Chip-Seq_ESCs_Mouse1.39884266
52RING1B_27294783_Chip-Seq_ESCs_Mouse1.38156209
53CDX2_19796622_ChIP-Seq_MESCs_Mouse1.38062678
54* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.37917950
55BMI1_23680149_ChIP-Seq_NPCS_Mouse1.37656720
56IGF1R_20145208_ChIP-Seq_DFB_Human1.36606713
57* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.36520825
58PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.34855840
59* RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.34492752
60EP300_21415370_ChIP-Seq_HL-1_Mouse1.34466238
61TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.32726973
62DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.32372866
63* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.32157279
64OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.32077417
65POU5F1_16153702_ChIP-ChIP_HESCs_Human1.31303072
66AR_19668381_ChIP-Seq_PC3_Human1.31233218
67VDR_22108803_ChIP-Seq_LS180_Human1.30913707
68POU3F2_20337985_ChIP-ChIP_501MEL_Human1.30800499
69TOP2B_26459242_ChIP-Seq_MCF-7_Human1.30358586
70STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.28618855
71KDM2B_26808549_Chip-Seq_SUP-B15_Human1.27667002
72MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.27358706
73RING1B_27294783_Chip-Seq_NPCs_Mouse1.27279514
74* GATA1_26923725_Chip-Seq_HPCs_Mouse1.25865424
75SMAD4_21799915_ChIP-Seq_A2780_Human1.25179304
76VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.25043734
77PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.24752292
78ZNF274_21170338_ChIP-Seq_K562_Hela1.23560325
79SOX2_21211035_ChIP-Seq_LN229_Gbm1.23366940
80TBX3_20139965_ChIP-Seq_MESCs_Mouse1.21652296
81KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.21337369
82DNAJC2_21179169_ChIP-ChIP_NT2_Human1.20906041
83TBX3_20139965_ChIP-Seq_ESCs_Mouse1.20842799
84HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.19212535
85RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.18669137
86ZNF217_24962896_ChIP-Seq_MCF-7_Human1.17091777
87ISL1_27105846_Chip-Seq_CPCs_Mouse1.16664885
88* SOX9_26525672_Chip-Seq_HEART_Mouse1.16639025
89TP53_16413492_ChIP-PET_HCT116_Human1.16250725
90* LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.15438971
91GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.14622292
92TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.13640718
93CTBP2_25329375_ChIP-Seq_LNCAP_Human1.12776185
94P53_22127205_ChIP-Seq_FIBROBLAST_Human1.12645535
95RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.10057020
96KDM2B_26808549_Chip-Seq_JURKAT_Human1.09813764
97THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.08022350
98STAT3_23295773_ChIP-Seq_U87_Human1.07811867
99YAP1_20516196_ChIP-Seq_MESCs_Mouse1.07503104
100UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.06609189
101ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.06104042
102EWS_26573619_Chip-Seq_HEK293_Human1.05442122
103ARNT_22903824_ChIP-Seq_MCF-7_Human1.03712207
104SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.03688399
105SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.03206687
106SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.03030593
107CTBP1_25329375_ChIP-Seq_LNCAP_Human1.01713839
108OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.01578870
109KDM2B_26808549_Chip-Seq_DND41_Human1.01175960
110* RUNX2_22187159_ChIP-Seq_PCA_Human1.00927996
111CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.00815250
112AHR_22903824_ChIP-Seq_MCF-7_Human1.00267659
113AR_25329375_ChIP-Seq_VCAP_Human1.00245806
114TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.99566367
115NR3C1_23031785_ChIP-Seq_PC12_Mouse0.98734817
116SMAD4_21741376_ChIP-Seq_HESCs_Human0.96446315
117MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.95759546
118SMAD3_21741376_ChIP-Seq_HESCs_Human0.95431591
119TP53_20018659_ChIP-ChIP_R1E_Mouse0.94758225
120CBX2_27304074_Chip-Seq_ESCs_Mouse0.94698713
121SMAD3_21741376_ChIP-Seq_EPCs_Human0.94258259
122ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.94144329
123TCF4_23295773_ChIP-Seq_U87_Human0.90751699
124CTNNB1_20460455_ChIP-Seq_HCT116_Human0.90225926
125TET1_21490601_ChIP-Seq_MESCs_Mouse0.89923846
126TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.89739427
127POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.89739427
128* SMAD3_21741376_ChIP-Seq_ESCs_Human0.89438600
129AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.89275968
130BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.89242055
131PIAS1_25552417_ChIP-Seq_VCAP_Human0.87347884
132NR3C1_21868756_ChIP-Seq_MCF10A_Human0.86482793
133TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.85875852
134RXR_22108803_ChIP-Seq_LS180_Human0.85033981
135CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.84142830

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity6.37372171
2MP0005423_abnormal_somatic_nervous3.73781552
3MP0000569_abnormal_digit_pigmentation3.71315838
4MP0003635_abnormal_synaptic_transmissio3.68933450
5MP0004270_analgesia3.02664302
6MP0003880_abnormal_central_pattern3.01511015
7MP0002063_abnormal_learning/memory/cond2.91264097
8MP0009046_muscle_twitch2.85191787
9MP0009745_abnormal_behavioral_response2.65838425
10MP0002064_seizures2.55635500
11MP0001486_abnormal_startle_reflex2.26706750
12MP0000778_abnormal_nervous_system2.24815012
13MP0002572_abnormal_emotion/affect_behav2.24692750
14MP0001968_abnormal_touch/_nociception2.16770522
15MP0004858_abnormal_nervous_system2.16296826
16MP0002734_abnormal_mechanical_nocicepti2.01869657
17MP0000751_myopathy1.84539267
18* MP0004811_abnormal_neuron_physiology1.84181307
19MP0008569_lethality_at_weaning1.83256805
20MP0002184_abnormal_innervation1.82841560
21MP0003787_abnormal_imprinting1.81141528
22MP0002067_abnormal_sensory_capabilities1.77878268
23MP0009780_abnormal_chondrocyte_physiolo1.76228584
24MP0001501_abnormal_sleep_pattern1.75104934
25MP0002272_abnormal_nervous_system1.69999982
26MP0001440_abnormal_grooming_behavior1.69102297
27MP0004885_abnormal_endolymph1.67630560
28MP0000955_abnormal_spinal_cord1.61914271
29MP0002733_abnormal_thermal_nociception1.58458307
30MP0002557_abnormal_social/conspecific_i1.56856191
31MP0004145_abnormal_muscle_electrophysio1.52778094
32MP0002736_abnormal_nociception_after1.49878010
33MP0004133_heterotaxia1.49571674
34MP0005503_abnormal_tendon_morphology1.46877288
35MP0003122_maternal_imprinting1.45304124
36MP0002882_abnormal_neuron_morphology1.43722324
37MP0005386_behavior/neurological_phenoty1.42226328
38MP0004924_abnormal_behavior1.42226328
39MP0004130_abnormal_muscle_cell1.41416888
40MP0003937_abnormal_limbs/digits/tail_de1.34529341
41MP0005623_abnormal_meninges_morphology1.34359982
42MP0002152_abnormal_brain_morphology1.34259647
43MP0003329_amyloid_beta_deposits1.34116083
44MP0002638_abnormal_pupillary_reflex1.31682180
45MP0000049_abnormal_middle_ear1.31446613
46MP0001970_abnormal_pain_threshold1.30498126
47MP0003705_abnormal_hypodermis_morpholog1.30402517
48MP0002066_abnormal_motor_capabilities/c1.28965213
49MP0002735_abnormal_chemical_nociception1.28292136
50MP0003890_abnormal_embryonic-extraembry1.26775834
51MP0006292_abnormal_olfactory_placode1.26193319
52MP0008877_abnormal_DNA_methylation1.25819765
53MP0003879_abnormal_hair_cell1.24621085
54MP0003172_abnormal_lysosome_physiology1.22823892
55MP0010030_abnormal_orbit_morphology1.20340535
56MP0004233_abnormal_muscle_weight1.18831381
57MP0005646_abnormal_pituitary_gland1.18688527
58MP0003633_abnormal_nervous_system1.17853889
59MP0008961_abnormal_basal_metabolism1.17505540
60MP0005187_abnormal_penis_morphology1.15826881
61MP0002697_abnormal_eye_size1.14904063
62MP0003136_yellow_coat_color1.14845139
63MP0006276_abnormal_autonomic_nervous1.13718935
64MP0001293_anophthalmia1.13157283
65MP0001299_abnormal_eye_distance/1.12457281
66MP0005645_abnormal_hypothalamus_physiol1.11972875
67MP0000537_abnormal_urethra_morphology1.10578141
68MP0001529_abnormal_vocalization1.07947465
69MP0004272_abnormal_basement_membrane1.06753053
70MP0001984_abnormal_olfaction1.06635157
71MP0000566_synostosis1.05153510
72MP0003137_abnormal_impulse_conducting1.05096529
73MP0003283_abnormal_digestive_organ1.03661836
74MP0000534_abnormal_ureter_morphology1.03296255
75MP0003942_abnormal_urinary_system1.03203541
76* MP0002909_abnormal_adrenal_gland1.03079913
77MP0001502_abnormal_circadian_rhythm1.02359973
78MP0003631_nervous_system_phenotype1.01583992
79MP0005248_abnormal_Harderian_gland1.01171333
80MP0003690_abnormal_glial_cell1.01037965
81MP0003938_abnormal_ear_development0.99920292
82MP0001485_abnormal_pinna_reflex0.99328827
83MP0002233_abnormal_nose_morphology0.98797691
84MP0003632_abnormal_nervous_system0.95311051
85MP0003634_abnormal_glial_cell0.95109075
86MP0002938_white_spotting0.94700862
87MP0003303_peritoneal_inflammation0.94690652
88MP0004085_abnormal_heartbeat0.94390505
89MP0002653_abnormal_ependyma_morphology0.93630743
90MP0003755_abnormal_palate_morphology0.93088739
91MP0005551_abnormal_eye_electrophysiolog0.92702184
92MP0003861_abnormal_nervous_system0.92382516
93MP0003385_abnormal_body_wall0.91640295
94MP0005167_abnormal_blood-brain_barrier0.90293341
95MP0000631_abnormal_neuroendocrine_gland0.89321770
96MP0005394_taste/olfaction_phenotype0.87901213
97MP0005499_abnormal_olfactory_system0.87901213
98MP0002102_abnormal_ear_morphology0.87236004
99MP0004742_abnormal_vestibular_system0.86038149
100MP0002089_abnormal_postnatal_growth/wei0.85164195
101MP0002234_abnormal_pharynx_morphology0.84391502
102MP0003935_abnormal_craniofacial_develop0.84120033
103MP0000026_abnormal_inner_ear0.83578438
104MP0000428_abnormal_craniofacial_morphol0.82777099
105MP0003646_muscle_fatigue0.82479350
106MP0003123_paternal_imprinting0.82424537
107MP0002090_abnormal_vision0.82181355
108MP0004510_myositis0.82143673
109MP0005377_hearing/vestibular/ear_phenot0.82104913
110MP0003878_abnormal_ear_physiology0.82104913
111MP0010368_abnormal_lymphatic_system0.81964821
112MP0001286_abnormal_eye_development0.80760068
113MP0002069_abnormal_eating/drinking_beha0.79150770
114MP0009250_abnormal_appendicular_skeleto0.78763341
115MP0003075_altered_response_to0.78469088
116MP0004215_abnormal_myocardial_fiber0.78201798
117MP0004142_abnormal_muscle_tone0.76981487
118MP0005076_abnormal_cell_differentiation0.76875564
119MP0002116_abnormal_craniofacial_bone0.76623903
120MP0002108_abnormal_muscle_morphology0.76590297
121MP0002752_abnormal_somatic_nervous0.76071385
122MP0002229_neurodegeneration0.75862261
123MP0003121_genomic_imprinting0.75591747
124MP0000604_amyloidosis0.75037554
125MP0000747_muscle_weakness0.74712704
126MP0001177_atelectasis0.73532738
127* MP0010769_abnormal_survival0.67045547
128MP0002082_postnatal_lethality0.64487159
129MP0010770_preweaning_lethality0.64487159
130MP0003045_fibrosis0.63039689
131MP0002822_catalepsy0.62552603
132* MP0010768_mortality/aging0.62423216
133MP0002081_perinatal_lethality0.61775213
134MP0004087_abnormal_muscle_fiber0.61774814
135MP0000759_abnormal_skeletal_muscle0.61079180
136MP0001188_hyperpigmentation0.60683312
137MP0005620_abnormal_muscle_contractility0.60359052
138MP0003119_abnormal_digestive_system0.57118337
139MP0000733_abnormal_muscle_development0.56522044

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)4.63080339
2Visual hallucinations (HP:0002367)4.10279157
3Focal seizures (HP:0007359)4.06904514
4Myokymia (HP:0002411)3.77948460
5Mutism (HP:0002300)3.33963770
6Progressive cerebellar ataxia (HP:0002073)3.32574434
7Action tremor (HP:0002345)3.30891296
8Genetic anticipation (HP:0003743)3.15448259
9Febrile seizures (HP:0002373)3.12357801
10Supranuclear gaze palsy (HP:0000605)3.06976100
11Epileptic encephalopathy (HP:0200134)2.91836121
12Abnormality of the lower motor neuron (HP:0002366)2.78011119
13Shallow orbits (HP:0000586)2.76359959
14Hyperacusis (HP:0010780)2.73345701
15Broad-based gait (HP:0002136)2.71970360
16Insomnia (HP:0100785)2.62865224
17Ankle clonus (HP:0011448)2.59311499
18Depression (HP:0000716)2.58657525
19Absence seizures (HP:0002121)2.56042531
20Postural instability (HP:0002172)2.55618805
21Urinary bladder sphincter dysfunction (HP:0002839)2.54072896
22Hemiplegia (HP:0002301)2.51886264
23Cutaneous finger syndactyly (HP:0010554)2.51375284
24Excessive salivation (HP:0003781)2.51026963
25Drooling (HP:0002307)2.51026963
26Generalized tonic-clonic seizures (HP:0002069)2.50373137
27Gaze-evoked nystagmus (HP:0000640)2.45219954
28Poor eye contact (HP:0000817)2.43163782
29Impaired social interactions (HP:0000735)2.37761252
30Abnormal social behavior (HP:0012433)2.37761252
31Dysdiadochokinesis (HP:0002075)2.35837148
32Papilledema (HP:0001085)2.35820137
33Macroorchidism (HP:0000053)2.35709040
34Hemiparesis (HP:0001269)2.35515314
35Morphological abnormality of the middle ear (HP:0008609)2.34867951
36Inappropriate behavior (HP:0000719)2.33794454
37Lower limb amyotrophy (HP:0007210)2.33747136
38Aplasia involving bones of the upper limbs (HP:0009823)2.33567990
39Aplasia of the phalanges of the hand (HP:0009802)2.33567990
40Aplasia involving bones of the extremities (HP:0009825)2.33567990
41Dysmetric saccades (HP:0000641)2.31720817
42Abnormal eating behavior (HP:0100738)2.30395368
43Dialeptic seizures (HP:0011146)2.28942206
44Cutaneous syndactyly (HP:0012725)2.28377177
45Pointed chin (HP:0000307)2.27859723
46Elfin facies (HP:0004428)2.27168928
47Atonic seizures (HP:0010819)2.23560443
48Abnormality of the labia minora (HP:0012880)2.21870979
49Turricephaly (HP:0000262)2.19736308
50Progressive inability to walk (HP:0002505)2.19163686
51Bundle branch block (HP:0011710)2.19031749
52Truncal ataxia (HP:0002078)2.18615173
53Cerebral aneurysm (HP:0004944)2.12600319
54Obstructive sleep apnea (HP:0002870)2.12482886
55Hyperventilation (HP:0002883)2.12397155
56Limb dystonia (HP:0002451)2.11572431
57Impaired smooth pursuit (HP:0007772)2.07945805
58Impaired vibration sensation in the lower limbs (HP:0002166)2.07251430
59Enlarged penis (HP:0000040)2.06867339
60Renovascular hypertension (HP:0100817)2.04285450
61Abnormality of ocular smooth pursuit (HP:0000617)2.03985415
62Diplopia (HP:0000651)2.03887982
63Abnormality of binocular vision (HP:0011514)2.03887982
64Cortical dysplasia (HP:0002539)2.03815613
65Stereotypic behavior (HP:0000733)2.02040309
66Agitation (HP:0000713)2.01129627
67Astrocytoma (HP:0009592)2.00402674
68Abnormality of the astrocytes (HP:0100707)2.00402674
69Septo-optic dysplasia (HP:0100842)1.99488071
70Absent speech (HP:0001344)1.97810512
71Protruding tongue (HP:0010808)1.97078587
72Vertebral arch anomaly (HP:0008438)1.96347174
73Torticollis (HP:0000473)1.94824701
74Apathy (HP:0000741)1.94302489
75Preaxial foot polydactyly (HP:0001841)1.91775090
76Abnormality of the ischium (HP:0003174)1.91404664
77Bradykinesia (HP:0002067)1.89926852
78Coronal craniosynostosis (HP:0004440)1.89862334
79Pancreatic fibrosis (HP:0100732)1.86596959
80Renal duplication (HP:0000075)1.86329327
81Cerebral inclusion bodies (HP:0100314)1.85501851
82Broad metatarsal (HP:0001783)1.84322400
83Absent frontal sinuses (HP:0002688)1.83170722
84Split foot (HP:0001839)1.82909649
85Hepatoblastoma (HP:0002884)1.82693522
86Neuronal loss in central nervous system (HP:0002529)1.81674728
87Annular pancreas (HP:0001734)1.80818377
88Flat cornea (HP:0007720)1.80678157
89Dysmetria (HP:0001310)1.80109463
90Amblyopia (HP:0000646)1.79787806
91Neoplasm of the adrenal cortex (HP:0100641)1.77144390
92Gait imbalance (HP:0002141)1.77030122
93Neonatal short-limb short stature (HP:0008921)1.76964146
94Bronchomalacia (HP:0002780)1.75545706
95Amyotrophic lateral sclerosis (HP:0007354)1.75528552
96Urinary urgency (HP:0000012)1.72439466
97Bowel diverticulosis (HP:0005222)1.72346983
98Aqueductal stenosis (HP:0002410)1.72326382
99Sacral dimple (HP:0000960)1.71538278
100Intention tremor (HP:0002080)1.71305802
101Epileptiform EEG discharges (HP:0011182)1.70436342
102Oligodactyly (hands) (HP:0001180)1.70341211
103Anxiety (HP:0000739)1.69898064
104Overriding aorta (HP:0002623)1.69731009
105Neurofibrillary tangles (HP:0002185)1.68753536
106Wrist flexion contracture (HP:0001239)1.68445919
107Ventricular fibrillation (HP:0001663)1.68123062
108Wide anterior fontanel (HP:0000260)1.68064301
109Obsessive-compulsive behavior (HP:0000722)1.67311343
110Vitreoretinal degeneration (HP:0000655)1.67022316
111Open mouth (HP:0000194)1.66992441
112Diminished motivation (HP:0000745)1.66118049
113Fetal akinesia sequence (HP:0001989)1.65214339
114Anophthalmia (HP:0000528)1.64687136
115Sleep apnea (HP:0010535)1.64611655
116Exotropia (HP:0000577)1.64155133
117Genital tract atresia (HP:0001827)1.64107462
118Rapidly progressive (HP:0003678)1.63774100
119Aplasia/Hypoplasia of the sternum (HP:0006714)1.63772601
120Megalencephaly (HP:0001355)1.63034209
121Chronic hepatic failure (HP:0100626)1.62906557
122High anterior hairline (HP:0009890)1.62745060
123Optic nerve hypoplasia (HP:0000609)1.61899024
124Heterotopia (HP:0002282)1.61401433
125Polyphagia (HP:0002591)1.61200559
126Status epilepticus (HP:0002133)1.60925429
127Aplasia/Hypoplasia of the brainstem (HP:0007362)1.60643662
128Hypoplasia of the brainstem (HP:0002365)1.60643662
129Disinhibition (HP:0000734)1.60086630
130Insidious onset (HP:0003587)1.59937945
131Termporal pattern (HP:0011008)1.59937945
132Difficulty running (HP:0009046)1.59825469
133Pachygyria (HP:0001302)1.59822717
134Abnormal EKG (HP:0003115)1.59482794
135Vaginal atresia (HP:0000148)1.59233304
136Aplasia/Hypoplasia of the tibia (HP:0005772)1.57468268
137Trigonocephaly (HP:0000243)1.57305051
138Fibular aplasia (HP:0002990)1.56994362
139Abnormality of midbrain morphology (HP:0002418)1.56485997
140Molar tooth sign on MRI (HP:0002419)1.56485997
141Partial agenesis of the corpus callosum (HP:0001338)1.55041078
142EEG with generalized epileptiform discharges (HP:0011198)1.53985861
143Micropenis (HP:0000054)1.51070080
144Nephronophthisis (HP:0000090)1.50386859
145Hypsarrhythmia (HP:0002521)1.50374399
146Choanal stenosis (HP:0000452)1.49098215
147Omphalocele (HP:0001539)1.48885620
148Overgrowth (HP:0001548)1.48561810
149Renal hypoplasia (HP:0000089)1.47388682
150Volvulus (HP:0002580)1.46688021
151Abnormality of the corticospinal tract (HP:0002492)1.45261250
152Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.44914114
153Soft skin (HP:0000977)1.44731214
154Narrow forehead (HP:0000341)1.44436782
155Broad long bones (HP:0005622)1.44104160
156True hermaphroditism (HP:0010459)1.43905772
157Spastic tetraplegia (HP:0002510)1.43854920
158Lissencephaly (HP:0001339)1.43722835
159Myelomeningocele (HP:0002475)1.40825792
160Humeroradial synostosis (HP:0003041)1.40187272
161Synostosis involving the elbow (HP:0003938)1.40187272
162Short 4th metacarpal (HP:0010044)1.39794482
163Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.39794482
164Myotonia (HP:0002486)1.39491012
165Infantile muscular hypotonia (HP:0008947)1.39068198
166Thyroid-stimulating hormone excess (HP:0002925)1.39016277

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MARK14.30598504
2MAP3K93.42436170
3NTRK33.36796343
4MAP3K42.60067569
5DAPK22.42301109
6PAK62.34991971
7SIK22.26967021
8NTRK22.21397364
9MINK12.19693315
10RIPK12.12941116
11EPHA42.07388842
12ICK2.00553686
13CAMK1G1.96579495
14CAMKK11.93347492
15LATS21.91557026
16STK381.83883167
17PHKG21.81251633
18PHKG11.81251633
19WNK31.80093890
20MAP2K71.70889799
21MAP2K41.68628807
22TRIB31.58122140
23PRKD31.56046779
24CAMK1D1.54091938
25KSR21.51860041
26KSR11.49950349
27BCR1.46512337
28DYRK21.38276404
29MAPK131.33938189
30SGK31.31330370
31NTRK11.24518170
32CDK51.23978179
33MKNK21.23522041
34TYRO31.22431260
35PRPF4B1.13984132
36TAOK11.13214169
37SGK21.12093197
38CDC71.09116940
39PDGFRA1.08647874
40PKN21.07799214
41WNK41.00355196
42DAPK10.97210974
43RET0.95712140
44FGFR20.94904461
45CAMK2B0.92922828
46DDR20.92863062
47STK38L0.92501130
48RIPK40.92232088
49ALK0.89689068
50PLK20.89306230
51MARK20.88615035
52SGK2230.88462453
53SGK4940.88462453
54PINK10.87178792
55TIE10.87141859
56CAMKK20.86089373
57CAMK10.85554239
58LMTK20.85110912
59STK110.84612500
60ERBB30.84170259
61PRKCG0.83281931
62PRKCH0.82974371
63SGK10.81826848
64MKNK10.81824727
65MAP4K20.80487634
66NEK20.78148566
67MAP3K60.75725756
68AKT30.74665267
69CSNK1G20.73845776
70STK390.73124946
71FRK0.72186949
72BMPR1B0.71893014
73TTN0.71503165
74CAMK40.70816468
75EPHB20.69642118
76LATS10.69345152
77UHMK10.69104007
78RPS6KA20.68412516
79ERBB20.67894693
80CDC42BPA0.67858140
81PAK30.67507393
82GRK50.67240131
83TNIK0.66771784
84MAP3K70.66625874
85CDK150.66183626
86CSNK1E0.65904917
87FES0.64690066
88MET0.63795713
89CDK180.63360285
90PNCK0.63069060
91PRKCE0.62692125
92MUSK0.61994351
93DMPK0.60761888
94BMX0.59843431
95DYRK1A0.58517611
96PTK20.57638744
97CDK140.57171226
98CDK11A0.56326186
99BRD40.56178150
100* RPS6KA30.55476074
101PRKAA10.55307588
102OXSR10.55279358
103PAK20.54519523
104PRKCZ0.53850372
105TAOK20.52978256
106CSNK1G10.52819997
107CAMK2A0.52457633
108PDGFRB0.52169502
109CSNK1A1L0.51353725
110OBSCN0.51117343
111MAPK120.49186509
112* MAPK100.48671398
113SCYL20.48259405
114SIK10.47332064
115PTK60.47113193
116NEK10.46602620
117FYN0.46064709
118MAP3K130.45493798
119PRKDC0.45449532
120FER0.44936693
121CAMK2D0.44810315
122PRKG10.44336656
123TRIM280.43517884
124PRKACB0.42901367
125* GSK3B0.42873965
126FGFR10.42076960
127CSNK1D0.41597650
128MAPK80.41390510
129CAMK2G0.41228110
130CSNK1G30.41210346
131PKN10.41026824
132ROCK10.40648904
133CDK120.39270177
134MTOR0.38967688
135CDK190.38137051
136CASK0.36459948
137WNK10.36392052

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050332.94186205
2Synaptic vesicle cycle_Homo sapiens_hsa047212.50088197
3Circadian entrainment_Homo sapiens_hsa047132.25670489
4Olfactory transduction_Homo sapiens_hsa047402.21357578
5GABAergic synapse_Homo sapiens_hsa047272.18877771
6Glutamatergic synapse_Homo sapiens_hsa047242.11437906
7Morphine addiction_Homo sapiens_hsa050321.98966667
8Long-term potentiation_Homo sapiens_hsa047201.98394755
9Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.96372376
10Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.91543214
11Salivary secretion_Homo sapiens_hsa049701.76713545
12Cholinergic synapse_Homo sapiens_hsa047251.61025889
13Dopaminergic synapse_Homo sapiens_hsa047281.59561711
14Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.59553595
15Aldosterone synthesis and secretion_Homo sapiens_hsa049251.58045293
16Amphetamine addiction_Homo sapiens_hsa050311.55313809
17Insulin secretion_Homo sapiens_hsa049111.49824135
18Oxytocin signaling pathway_Homo sapiens_hsa049211.49228768
19Gastric acid secretion_Homo sapiens_hsa049711.48452154
20Type II diabetes mellitus_Homo sapiens_hsa049301.46401010
21GnRH signaling pathway_Homo sapiens_hsa049121.45097545
22Glioma_Homo sapiens_hsa052141.43700966
23Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.39195289
24Renin secretion_Homo sapiens_hsa049241.38824563
25Gap junction_Homo sapiens_hsa045401.38045650
26Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.35338686
27Axon guidance_Homo sapiens_hsa043601.34509731
28Long-term depression_Homo sapiens_hsa047301.33932826
29ECM-receptor interaction_Homo sapiens_hsa045121.29189625
30Calcium signaling pathway_Homo sapiens_hsa040201.28985006
31Dorso-ventral axis formation_Homo sapiens_hsa043201.28391837
32Cocaine addiction_Homo sapiens_hsa050301.25757212
33Tight junction_Homo sapiens_hsa045301.24685032
34Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.20661863
35Dilated cardiomyopathy_Homo sapiens_hsa054141.20308335
36Taste transduction_Homo sapiens_hsa047421.20248168
37Estrogen signaling pathway_Homo sapiens_hsa049151.19899669
38ErbB signaling pathway_Homo sapiens_hsa040121.17868269
39Endometrial cancer_Homo sapiens_hsa052131.17579328
40Nitrogen metabolism_Homo sapiens_hsa009101.17190349
41cAMP signaling pathway_Homo sapiens_hsa040241.15540241
42Adherens junction_Homo sapiens_hsa045201.11950133
43Phosphatidylinositol signaling system_Homo sapiens_hsa040701.10969534
44Serotonergic synapse_Homo sapiens_hsa047261.10465686
45Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.08406219
46Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.07552173
47Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.04675507
48Neurotrophin signaling pathway_Homo sapiens_hsa047221.03872347
49Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.03688460
50Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.02753293
51Phospholipase D signaling pathway_Homo sapiens_hsa040721.01440551
52Melanogenesis_Homo sapiens_hsa049161.00264995
53Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.98937353
54Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.98829931
55mTOR signaling pathway_Homo sapiens_hsa041500.98669920
56cGMP-PKG signaling pathway_Homo sapiens_hsa040220.98054857
57Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.95334519
58Thyroid hormone signaling pathway_Homo sapiens_hsa049190.94330974
59Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.90947792
60Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.90040510
61Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.87631046
62Longevity regulating pathway - mammal_Homo sapiens_hsa042110.86082760
63Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.84237005
64Phototransduction_Homo sapiens_hsa047440.82864378
65Lysine degradation_Homo sapiens_hsa003100.82325401
66Non-small cell lung cancer_Homo sapiens_hsa052230.81671024
67Insulin signaling pathway_Homo sapiens_hsa049100.80893568
68Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.80682771
69MAPK signaling pathway_Homo sapiens_hsa040100.80392212
70Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.79673527
71Colorectal cancer_Homo sapiens_hsa052100.79479413
72Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.78545373
73Choline metabolism in cancer_Homo sapiens_hsa052310.78069958
74Thyroid hormone synthesis_Homo sapiens_hsa049180.77021167
75Oocyte meiosis_Homo sapiens_hsa041140.76518314
76Protein digestion and absorption_Homo sapiens_hsa049740.76315479
77Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.75080866
78Steroid biosynthesis_Homo sapiens_hsa001000.74916331
79Renal cell carcinoma_Homo sapiens_hsa052110.74763116
80Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.74733523
81Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.73910561
82Carbohydrate digestion and absorption_Homo sapiens_hsa049730.73464390
83Vascular smooth muscle contraction_Homo sapiens_hsa042700.72702198
84Chronic myeloid leukemia_Homo sapiens_hsa052200.72275158
85Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.70969484
86Rap1 signaling pathway_Homo sapiens_hsa040150.70835822
87VEGF signaling pathway_Homo sapiens_hsa043700.67632434
88Wnt signaling pathway_Homo sapiens_hsa043100.66979993
89TGF-beta signaling pathway_Homo sapiens_hsa043500.66844384
90Propanoate metabolism_Homo sapiens_hsa006400.66841177
91Butanoate metabolism_Homo sapiens_hsa006500.65733847
92Ovarian steroidogenesis_Homo sapiens_hsa049130.64487719
93Circadian rhythm_Homo sapiens_hsa047100.64399037
94Proteoglycans in cancer_Homo sapiens_hsa052050.63413296
95Central carbon metabolism in cancer_Homo sapiens_hsa052300.60481835
96Ras signaling pathway_Homo sapiens_hsa040140.60463534
97Arginine biosynthesis_Homo sapiens_hsa002200.59970173
98Glucagon signaling pathway_Homo sapiens_hsa049220.59871393
99Vitamin B6 metabolism_Homo sapiens_hsa007500.59801498
100Endocytosis_Homo sapiens_hsa041440.59181128
101Basal cell carcinoma_Homo sapiens_hsa052170.58920435
102Prolactin signaling pathway_Homo sapiens_hsa049170.58527461
103Inositol phosphate metabolism_Homo sapiens_hsa005620.58215957
104Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.58193730
105Focal adhesion_Homo sapiens_hsa045100.57750990
106Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.57056691
107beta-Alanine metabolism_Homo sapiens_hsa004100.56925799
108Fatty acid biosynthesis_Homo sapiens_hsa000610.56435368
109Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.55609227
110Hippo signaling pathway_Homo sapiens_hsa043900.55246891
111Prion diseases_Homo sapiens_hsa050200.53826002
112Pyruvate metabolism_Homo sapiens_hsa006200.53573743
113Arginine and proline metabolism_Homo sapiens_hsa003300.53510843
114Melanoma_Homo sapiens_hsa052180.52584402
115Platelet activation_Homo sapiens_hsa046110.52541552
116Regulation of actin cytoskeleton_Homo sapiens_hsa048100.52217170
117Alcoholism_Homo sapiens_hsa050340.51822541
118Chemokine signaling pathway_Homo sapiens_hsa040620.51781264
119AMPK signaling pathway_Homo sapiens_hsa041520.51622165
120Bile secretion_Homo sapiens_hsa049760.51041623
121Sphingolipid signaling pathway_Homo sapiens_hsa040710.51032998
122Hedgehog signaling pathway_Homo sapiens_hsa043400.50842098
123Basal transcription factors_Homo sapiens_hsa030220.49552744
124Amoebiasis_Homo sapiens_hsa051460.48965081
125Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.48393059
126Cardiac muscle contraction_Homo sapiens_hsa042600.48320971
127Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.48044216
128Histidine metabolism_Homo sapiens_hsa003400.42717869
129MicroRNAs in cancer_Homo sapiens_hsa052060.41730019
130PI3K-Akt signaling pathway_Homo sapiens_hsa041510.41054567
131Cysteine and methionine metabolism_Homo sapiens_hsa002700.40237743
132Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.40146464
133Pathways in cancer_Homo sapiens_hsa052000.38703934

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »