ITSN2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a cytoplasmic protein which contains SH3 domains. This protein is a member of a family of proteins involved in clathrin-mediated endocytosis. Intersectin 2 is thought to regulate the formation of clathrin-coated vesicles and also may function in the induction of T cell antigen receptor (TCR) endocytosis. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of gamma-delta T cell activation (GO:0046645)5.58959549
2antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.38636462
3antigen processing and presentation of endogenous antigen (GO:0019883)4.41583250
4regulation of B cell receptor signaling pathway (GO:0050855)4.40595531
5regulation of interferon-beta biosynthetic process (GO:0045357)4.29885098
6antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.24039791
7antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.24039791
8regulation of gamma-delta T cell differentiation (GO:0045586)4.21915154
9negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.18051654
10negative regulation of cell killing (GO:0031342)4.18051654
11B cell receptor signaling pathway (GO:0050853)4.14853344
12positive thymic T cell selection (GO:0045059)4.09538669
13detection of other organism (GO:0098543)4.08886195
14regulation of gamma-delta T cell activation (GO:0046643)4.01081076
15positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.91784634
16positive regulation of B cell differentiation (GO:0045579)3.87980897
17negative thymic T cell selection (GO:0045060)3.87500102
18response to peptidoglycan (GO:0032494)3.87394541
19detection of molecule of bacterial origin (GO:0032490)3.87321011
20detection of bacterium (GO:0016045)3.84624995
21negative T cell selection (GO:0043383)3.79844196
22regulation of interleukin-12 biosynthetic process (GO:0045075)3.78365111
23detection of external biotic stimulus (GO:0098581)3.71772807
24modulation by symbiont of host immune response (GO:0052553)3.68815354
25positive regulation by symbiont of host defense response (GO:0052509)3.68815354
26modulation by symbiont of host defense response (GO:0052031)3.68815354
27modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.68815354
28modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.68815354
29positive regulation by organism of defense response of other organism involved in symbiotic interact3.68815354
30positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.59358106
31regulation of B cell differentiation (GO:0045577)3.55113189
32negative regulation of interleukin-12 production (GO:0032695)3.52261641
33negative regulation of T cell mediated immunity (GO:0002710)3.51801605
34mature B cell differentiation (GO:0002335)3.50505772
35leukocyte aggregation (GO:0070486)3.48426653
36germinal center formation (GO:0002467)3.45023932
37microglial cell activation (GO:0001774)3.43268402
38thymic T cell selection (GO:0045061)3.42871912
39immunoglobulin mediated immune response (GO:0016064)3.39369956
40histone H3-K36 demethylation (GO:0070544)3.36996799
41positive T cell selection (GO:0043368)3.36050083
42negative regulation of erythrocyte differentiation (GO:0045647)3.34868154
43neutrophil activation involved in immune response (GO:0002283)3.33661702
44B cell homeostasis (GO:0001782)3.33362261
45negative regulation of lymphocyte mediated immunity (GO:0002707)3.33055439
46positive regulation of interferon-alpha production (GO:0032727)3.30473494
47T cell selection (GO:0045058)3.28791390
48negative regulation of B cell proliferation (GO:0030889)3.27168042
49NIK/NF-kappaB signaling (GO:0038061)3.24105439
50cellular extravasation (GO:0045123)3.21496341
51detection of biotic stimulus (GO:0009595)3.20675640
52regulation of interferon-alpha production (GO:0032647)3.20651995
53histone H3-K4 trimethylation (GO:0080182)3.20571890
54neutrophil activation (GO:0042119)3.17277255
55response to host (GO:0075136)3.16640036
56response to host defenses (GO:0052200)3.16640036
57response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.16640036
58macrophage activation (GO:0042116)3.14161363
59macrophage activation involved in immune response (GO:0002281)3.09773535
60positive regulation of cellular amide metabolic process (GO:0034250)3.07690097
61regulation of antigen receptor-mediated signaling pathway (GO:0050854)3.03950845
62positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)3.02941815
63hepatocyte apoptotic process (GO:0097284)3.02423699
64tolerance induction (GO:0002507)3.01733678
65positive regulation of histone deacetylation (GO:0031065)3.01600403
66response to protozoan (GO:0001562)2.96497228
67JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.94772982
68negative regulation of leukocyte mediated immunity (GO:0002704)2.94245752
69pinocytosis (GO:0006907)2.92722134
70response to muramyl dipeptide (GO:0032495)2.90085961
71regulation of alpha-beta T cell proliferation (GO:0046640)2.89576655
72granulocyte activation (GO:0036230)2.88155641
73mitotic sister chromatid cohesion (GO:0007064)2.86777489
74defense response to protozoan (GO:0042832)2.85360620
75regulation of dendritic cell antigen processing and presentation (GO:0002604)2.85233754
76negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.84336463
77negative regulation of T-helper cell differentiation (GO:0045623)2.84336463
78cellular response to ethanol (GO:0071361)2.84204397
79myeloid cell activation involved in immune response (GO:0002275)2.84031331
80lymphocyte homeostasis (GO:0002260)2.83673734
81neutrophil mediated immunity (GO:0002446)2.82561722
82definitive hemopoiesis (GO:0060216)2.82296610
83regulation of mast cell degranulation (GO:0043304)2.82213416
84T cell migration (GO:0072678)2.81771831
85myeloid dendritic cell activation (GO:0001773)2.81609773
86production of molecular mediator involved in inflammatory response (GO:0002532)2.80587710
87T-helper 1 type immune response (GO:0042088)2.79912762
88regulation of B cell proliferation (GO:0030888)2.79437765
89negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.78897778
90interferon-gamma-mediated signaling pathway (GO:0060333)2.78366938
91positive regulation of mast cell activation (GO:0033005)2.76684432
92regulation of tolerance induction (GO:0002643)2.76285978
93antigen receptor-mediated signaling pathway (GO:0050851)2.74443870
94regulation of mast cell activation (GO:0033003)2.73043966
95mature B cell differentiation involved in immune response (GO:0002313)2.72615981
96lipopolysaccharide-mediated signaling pathway (GO:0031663)2.72351628
97interferon-gamma production (GO:0032609)2.72111424
98response to interleukin-15 (GO:0070672)2.72085017
99megakaryocyte development (GO:0035855)2.71852416
100positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.71487782
101negative regulation of granulocyte differentiation (GO:0030853)2.71345288
102T cell costimulation (GO:0031295)2.69305686
103regulation of T cell tolerance induction (GO:0002664)2.67074727
104negative regulation of adaptive immune response based on somatic recombination of immune receptors b2.66672887
105B cell proliferation (GO:0042100)2.65325564
106positive regulation of interferon-beta production (GO:0032728)2.64997613
107I-kappaB phosphorylation (GO:0007252)2.64712148
108lymphocyte costimulation (GO:0031294)2.62832769
109regulation of granulocyte differentiation (GO:0030852)2.62639776
110leukocyte cell-cell adhesion (GO:0007159)2.62449301
111positive regulation of antigen processing and presentation (GO:0002579)2.61780424
112T cell homeostasis (GO:0043029)2.61157322
113regulation of histone H3-K27 methylation (GO:0061085)2.59707480
114positive regulation of macrophage differentiation (GO:0045651)2.59440592
115respiratory burst (GO:0045730)2.58356245
116regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.58319738
117B cell mediated immunity (GO:0019724)2.57995167
118mast cell activation (GO:0045576)2.56920933
119myeloid dendritic cell differentiation (GO:0043011)2.56087648
120regulation of necroptotic process (GO:0060544)2.55985480
121response to type I interferon (GO:0034340)2.55286399
122antigen processing and presentation via MHC class Ib (GO:0002475)2.53764401
123positive regulation of interleukin-2 production (GO:0032743)2.52394514
124positive regulation of granulocyte differentiation (GO:0030854)2.52301442
125cytoplasmic mRNA processing body assembly (GO:0033962)2.51669897
126leukocyte homeostasis (GO:0001776)2.50135443
127cellular response to interleukin-15 (GO:0071350)2.49022010
128response to host immune response (GO:0052572)2.48175845
129response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.48175845
130growth hormone receptor signaling pathway (GO:0060396)2.48035779
131negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)2.47422329
132positive regulation of B cell proliferation (GO:0030890)2.46908868
133regulation of syncytium formation by plasma membrane fusion (GO:0060142)2.46399256
134type I interferon signaling pathway (GO:0060337)2.44233698
135cellular response to type I interferon (GO:0071357)2.44233698

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP3_17237761_ChIP-ChIP_TREG_Mouse5.75227637
2IRF8_22096565_ChIP-ChIP_GC-B_Human4.80905300
3STAT6_20620947_ChIP-Seq_CD4_POS_T_Human4.71863114
4IRF8_21731497_ChIP-ChIP_J774_Mouse3.74533198
5EGR1_19374776_ChIP-ChIP_THP-1_Human3.47899485
6BP1_19119308_ChIP-ChIP_Hs578T_Human3.27699373
7* MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.16881942
8IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.15627339
9IRF8_27001747_Chip-Seq_BMDM_Mouse3.13788773
10NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.12461251
11SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.11728107
12STAT3_20064451_ChIP-Seq_CD4+T_Mouse3.08546028
13E2F7_22180533_ChIP-Seq_HELA_Human3.06892798
14RUNX_20019798_ChIP-Seq_JUKART_Human2.90976093
15FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.82159302
16SCL_19346495_ChIP-Seq_HPC-7_Human2.80877346
17* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.74906074
18IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.69909421
19MYB_21317192_ChIP-Seq_ERMYB_Mouse2.55079593
20MYB_26560356_Chip-Seq_TH2_Human2.33796647
21Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.24669932
22VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.23603439
23MYB_26560356_Chip-Seq_TH1_Human2.17897557
24MYC_22102868_ChIP-Seq_BL_Human2.15273687
25* SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.14811473
26VDR_21846776_ChIP-Seq_THP-1_Human2.06369469
27STAT4_19710469_ChIP-ChIP_TH1__Mouse1.97702235
28MAF_26560356_Chip-Seq_TH1_Human1.97203516
29* BRD4_27068464_Chip-Seq_AML-cells_Mouse1.97129007
30SMAD_19615063_ChIP-ChIP_OVARY_Human1.93940614
31TCF7_22412390_ChIP-Seq_EML_Mouse1.87905044
32* SPI1_23127762_ChIP-Seq_K562_Human1.86217615
33VDR_24763502_ChIP-Seq_THP-1_Human1.81311383
34STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.78542470
35UTX_26944678_Chip-Seq_JUKART_Human1.74049574
36SPI1_23547873_ChIP-Seq_NB4_Human1.71262006
37FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.70775951
38RUNX1_22412390_ChIP-Seq_EML_Mouse1.65773563
39* PU_27001747_Chip-Seq_BMDM_Mouse1.64455922
40* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.64329096
41KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.63568796
42BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.62585577
43GATA1_22025678_ChIP-Seq_K562_Human1.57229557
44VDR_24787735_ChIP-Seq_THP-1_Human1.56929566
45ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.55757756
46E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.54767637
47* GATA3_27048872_Chip-Seq_THYMUS_Human1.54079326
48GATA2_21666600_ChIP-Seq_HMVEC_Human1.52947610
49CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.42999164
50* NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.41444365
51KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.40000270
52RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.39352262
53FOXO3_23340844_ChIP-Seq_DLD1_Human1.39032680
54KDM2B_26808549_Chip-Seq_DND41_Human1.30451772
55FOXM1_23109430_ChIP-Seq_U2OS_Human1.29652827
56KDM2B_26808549_Chip-Seq_SUP-B15_Human1.25943875
57TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.25665038
58NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.18668689
59PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.16825030
60GATA2_22383799_ChIP-Seq_G1ME_Mouse1.16784686
61PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.15756657
62SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.11980036
63* MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.11707705
64GATA3_26560356_Chip-Seq_TH2_Human1.10789207
65TP53_16413492_ChIP-PET_HCT116_Human1.10181572
66NOTCH1_21737748_ChIP-Seq_TLL_Human1.09742226
67RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.09319103
68STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.09148844
69CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.06170191
70FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.04930047
71SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.02491762
72GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.00770708
73MAF_26560356_Chip-Seq_TH2_Human1.00587662
74* GATA1_19941827_ChIP-Seq_MEL_Mouse0.99735949
75* GATA2_19941826_ChIP-Seq_K562_Human0.99228378
76STAT6_21828071_ChIP-Seq_BEAS2B_Human0.98718966
77VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.98289520
78* GATA1_19941826_ChIP-Seq_K562_Human0.96977044
79GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.95896058
80KDM2B_26808549_Chip-Seq_JURKAT_Human0.94930978
81FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.92140019
82CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.90280998
83* LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.90215968
84CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.90126178
85ELK3_25401928_ChIP-Seq_HUVEC_Human0.87939637
86ESR1_20079471_ChIP-ChIP_T-47D_Human0.87893369
87* SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.87873534
88* SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.87873534
89GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.87510742
90CIITA_25753668_ChIP-Seq_RAJI_Human0.87180710
91SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.85681581
92GATA1_19941827_ChIP-Seq_MEL86_Mouse0.85091411
93KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.84647788
94CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.82566332
95BRD4_25478319_ChIP-Seq_HGPS_Human0.82356221
96PPAR_26484153_Chip-Seq_NCI-H1993_Human0.82288433
97PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.81229933
98CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.81039592
99PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.79733933
100LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.79695124
101SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.79183170
102NCOR1_26117541_ChIP-Seq_K562_Human0.77901884
103ZNF217_24962896_ChIP-Seq_MCF-7_Human0.77871999
104RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.77365818
105CTNNB1_20460455_ChIP-Seq_HCT116_Human0.75796152
106NFIB_24661679_ChIP-Seq_LUNG_Mouse0.74993505
107ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.74630937
108SMRT_27268052_Chip-Seq_Bcells_Human0.72975062
109GATA1_22383799_ChIP-Seq_G1ME_Mouse0.71587607
110SALL1_21062744_ChIP-ChIP_HESCs_Human0.71526028
111FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.70765779
112GATA3_26560356_Chip-Seq_TH1_Human0.70301648
113PKCTHETA_26484144_Chip-Seq_BREAST_Human0.70126388
114RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.68161911
115PU.1_20513432_ChIP-Seq_Bcells_Mouse0.66302741
116CDX2_19796622_ChIP-Seq_MESCs_Mouse0.65631521
117TFEB_21752829_ChIP-Seq_HELA_Human0.65584750
118ETS1_22383799_ChIP-Seq_G1ME_Mouse0.62258647
119BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.61055798
120CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.60406986
121PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.59174357

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation3.91746489
2MP0000569_abnormal_digit_pigmentation3.40077675
3MP0002166_altered_tumor_susceptibility3.00071335
4MP0001800_abnormal_humoral_immune2.96832632
5MP0001790_abnormal_immune_system2.92977065
6MP0005387_immune_system_phenotype2.92977065
7MP0003303_peritoneal_inflammation2.83805081
8MP0000685_abnormal_immune_system2.81207850
9MP0005671_abnormal_response_to2.76794050
10MP0003300_gastrointestinal_ulcer2.73332472
11MP0002452_abnormal_antigen_presenting2.64160438
12MP0003763_abnormal_thymus_physiology2.56224418
13MP0002396_abnormal_hematopoietic_system2.51342673
14MP0005000_abnormal_immune_tolerance2.48262765
15MP0002006_tumorigenesis2.46448246
16MP0003436_decreased_susceptibility_to2.42003038
17MP0002723_abnormal_immune_serum2.36197086
18MP0001873_stomach_inflammation2.35687097
19MP0002420_abnormal_adaptive_immunity2.32364535
20MP0002419_abnormal_innate_immunity2.31259647
21MP0001819_abnormal_immune_cell2.29889647
22MP0004510_myositis2.20528387
23MP0002398_abnormal_bone_marrow2.13257365
24MP0005025_abnormal_response_to2.06185433
25MP0004808_abnormal_hematopoietic_stem1.94942522
26MP0000716_abnormal_immune_system1.94252479
27MP0004947_skin_inflammation1.93899502
28MP0008260_abnormal_autophagy1.91679017
29MP0002405_respiratory_system_inflammati1.88627455
30MP0005464_abnormal_platelet_physiology1.88161084
31MP0009785_altered_susceptibility_to1.84088553
32MP0005174_abnormal_tail_pigmentation1.83937850
33MP0000689_abnormal_spleen_morphology1.81294146
34MP0010352_gastrointestinal_tract_polyps1.80521677
35MP0005310_abnormal_salivary_gland1.74913719
36MP0008057_abnormal_DNA_replication1.69094934
37MP0010155_abnormal_intestine_physiology1.68991340
38MP0002148_abnormal_hypersensitivity_rea1.68474849
39MP0002722_abnormal_immune_system1.67591069
40MP0006082_CNS_inflammation1.64700985
41MP0009278_abnormal_bone_marrow1.60800827
42MP0001853_heart_inflammation1.60463297
43MP0003183_abnormal_peptide_metabolism1.58677737
44MP0005451_abnormal_body_composition1.57893623
45MP0002429_abnormal_blood_cell1.57174292
46MP0000703_abnormal_thymus_morphology1.52457282
47MP0001545_abnormal_hematopoietic_system1.51240173
48MP0005397_hematopoietic_system_phenotyp1.51240173
49MP0002009_preneoplasia1.51120052
50MP0001845_abnormal_inflammatory_respons1.49958905
51MP0000465_gastrointestinal_hemorrhage1.46782066
52MP0003045_fibrosis1.43682622
53MP0005076_abnormal_cell_differentiation1.39093402
54MP0003566_abnormal_cell_adhesion1.34722726
55MP0005058_abnormal_lysosome_morphology1.33195007
56MP0004381_abnormal_hair_follicle1.31183888
57MP0003656_abnormal_erythrocyte_physiolo1.31137338
58MP0003172_abnormal_lysosome_physiology1.30878428
59MP0010307_abnormal_tumor_latency1.30347049
60MP0001533_abnormal_skeleton_physiology1.30216473
61MP0003724_increased_susceptibility_to1.29601203
62MP0002933_joint_inflammation1.26194925
63MP0009333_abnormal_splenocyte_physiolog1.26000872
64MP0000015_abnormal_ear_pigmentation1.25053632
65MP0003866_abnormal_defecation1.24968846
66MP0003448_altered_tumor_morphology1.17431684
67MP0003787_abnormal_imprinting1.16292018
68MP0003091_abnormal_cell_migration1.15668676
69MP0002254_reproductive_system_inflammat1.13589308
70MP0002138_abnormal_hepatobiliary_system1.13537829
71MP0001851_eye_inflammation1.13341877
72MP0003828_pulmonary_edema1.13180267
73MP0002998_abnormal_bone_remodeling1.10161699
74MP0004883_abnormal_blood_vessel1.08469805
75MP0008004_abnormal_stomach_pH1.07672011
76MP0003453_abnormal_keratinocyte_physiol1.06144862
77MP0002877_abnormal_melanocyte_morpholog1.05780980
78MP0000858_altered_metastatic_potential0.98398938
79MP0000490_abnormal_crypts_of0.97696857
80MP0010234_abnormal_vibrissa_follicle0.94363451
81MP0008469_abnormal_protein_level0.92819175
82MP0003690_abnormal_glial_cell0.89349889
83MP0005164_abnormal_response_to0.89023091
84MP0005023_abnormal_wound_healing0.87031171
85MP0003191_abnormal_cellular_cholesterol0.87021475
86MP0008961_abnormal_basal_metabolism0.85449346
87MP0000383_abnormal_hair_follicle0.84433969
88MP0002019_abnormal_tumor_incidence0.82220162
89MP0009115_abnormal_fat_cell0.81592638
90MP0000371_diluted_coat_color0.81435725
91MP0010678_abnormal_skin_adnexa0.81189971
92MP0000604_amyloidosis0.81063205
93MP0002132_abnormal_respiratory_system0.81041393
94MP0005075_abnormal_melanosome_morpholog0.79908023
95MP0002095_abnormal_skin_pigmentation0.78689313
96MP0003075_altered_response_to0.78604741
97MP0001879_abnormal_lymphatic_vessel0.76158158
98MP0000249_abnormal_blood_vessel0.73634631
99MP0004130_abnormal_muscle_cell0.73611906
100MP0004484_altered_response_of0.71883665
101MP0003252_abnormal_bile_duct0.71696647
102MP0001216_abnormal_epidermal_layer0.71442292
103MP0000733_abnormal_muscle_development0.71386284
104MP0002332_abnormal_exercise_endurance0.70636226
105MP0009764_decreased_sensitivity_to0.69998738
106MP0001191_abnormal_skin_condition0.69442695
107MP0002928_abnormal_bile_duct0.68320976
108MP0005409_darkened_coat_color0.67866523
109MP0009763_increased_sensitivity_to0.66574091
110MP0008877_abnormal_DNA_methylation0.65510268
111MP0002136_abnormal_kidney_physiology0.63997774
112MP0003221_abnormal_cardiomyocyte_apopto0.63985430
113MP0005621_abnormal_cell_physiology0.63203455
114MP0004185_abnormal_adipocyte_glucose0.61822656
115MP0003795_abnormal_bone_structure0.60294100
116MP0000767_abnormal_smooth_muscle0.59878247
117MP0000609_abnormal_liver_physiology0.58882297
118MP0009765_abnormal_xenobiotic_induced0.58160630
119MP0001663_abnormal_digestive_system0.57481548
120MP0005166_decreased_susceptibility_to0.56324488
121MP0005390_skeleton_phenotype0.54023989

Predicted human phenotypes

RankGene SetZ-score
1Eczematoid dermatitis (HP:0000976)4.47287780
2Recurrent abscess formation (HP:0002722)4.21806017
3Abnormality of the fingertips (HP:0001211)4.10113402
4Recurrent viral infections (HP:0004429)4.09939805
5Recurrent fungal infections (HP:0002841)4.01943421
6Recurrent bacterial skin infections (HP:0005406)4.00144430
7Agammaglobulinemia (HP:0004432)3.77532398
8Colitis (HP:0002583)3.62306894
9Cellulitis (HP:0100658)3.57218290
10Chronic mucocutaneous candidiasis (HP:0002728)3.40303711
11Recurrent cutaneous fungal infections (HP:0011370)3.40303711
12Gastrointestinal infarctions (HP:0005244)3.39233608
13IgM deficiency (HP:0002850)3.35367050
14Autoimmune thrombocytopenia (HP:0001973)3.34213763
15Inflammation of the large intestine (HP:0002037)3.32439691
16Abnormal delayed hypersensitivity skin test (HP:0002963)3.20533473
17Recurrent skin infections (HP:0001581)3.17496153
18Gastrointestinal stroma tumor (HP:0100723)3.07720531
19Gastrointestinal inflammation (HP:0004386)3.06079226
20Vasculitis (HP:0002633)2.99309677
21T lymphocytopenia (HP:0005403)2.99062396
22Recurrent bronchitis (HP:0002837)2.98847106
23Meningitis (HP:0001287)2.95520539
24Myositis (HP:0100614)2.95204623
25Abnormality of T cell number (HP:0011839)2.94768146
26Epistaxis (HP:0000421)2.87508867
27Panhypogammaglobulinemia (HP:0003139)2.87152829
28Chest pain (HP:0100749)2.81350900
29Mediastinal lymphadenopathy (HP:0100721)2.80410102
30Chronic otitis media (HP:0000389)2.79612045
31Lymphopenia (HP:0001888)2.77730552
32Periodontitis (HP:0000704)2.76702775
33Urticaria (HP:0001025)2.73668067
34Thyroiditis (HP:0100646)2.71446082
35Acute myeloid leukemia (HP:0004808)2.70810716
36Osteomyelitis (HP:0002754)2.69746416
37Volvulus (HP:0002580)2.66816385
38Autoimmune hemolytic anemia (HP:0001890)2.64193829
39Increased IgE level (HP:0003212)2.63143893
40Macroorchidism (HP:0000053)2.62998402
41Abnormality of cells of the lymphoid lineage (HP:0012140)2.61908929
42Recurrent gram-negative bacterial infections (HP:0005420)2.61339905
43Hematochezia (HP:0002573)2.59248680
44Retrobulbar optic neuritis (HP:0100654)2.57903875
45Optic neuritis (HP:0100653)2.57903875
46Abnormality of macrophages (HP:0004311)2.57502030
47Spontaneous hematomas (HP:0007420)2.53192654
48Pustule (HP:0200039)2.50741322
49Pulmonary embolism (HP:0002204)2.49059455
50Gingivitis (HP:0000230)2.47375514
51Absent frontal sinuses (HP:0002688)2.47164718
52IgA deficiency (HP:0002720)2.43804151
53Verrucae (HP:0200043)2.40822586
54Papilloma (HP:0012740)2.40822586
55B lymphocytopenia (HP:0010976)2.40694349
56Abnormality of B cell number (HP:0010975)2.40694349
57Arterial thrombosis (HP:0004420)2.39885348
58Thoracic kyphosis (HP:0002942)2.39316310
59Chronic diarrhea (HP:0002028)2.38436170
60Abnormality of T cells (HP:0002843)2.37513858
61Orchitis (HP:0100796)2.35071194
62Gangrene (HP:0100758)2.34328939
63Myocardial infarction (HP:0001658)2.33591170
64Emphysema (HP:0002097)2.33175262
65Eosinophilia (HP:0001880)2.31878672
66Elevated erythrocyte sedimentation rate (HP:0003565)2.31606999
67Slow saccadic eye movements (HP:0000514)2.30781652
68Recurrent pneumonia (HP:0006532)2.29224053
69Fatigue (HP:0012378)2.28178709
70Pulmonary infiltrates (HP:0002113)2.23883085
71Abnormality of the thoracic spine (HP:0100711)2.23400811
72Recurrent sinusitis (HP:0011108)2.21942094
73Disinhibition (HP:0000734)2.21111653
74Chronic obstructive pulmonary disease (HP:0006510)2.20772215
75Obstructive lung disease (HP:0006536)2.20772215
76Prolonged bleeding time (HP:0003010)2.18007258
77Abnormality of the pleura (HP:0002103)2.16278164
78Hypergammaglobulinemia (HP:0010702)2.13775400
79Lip pit (HP:0100267)2.12382869
80Papilledema (HP:0001085)2.11108134
81Abnormality of the prostate (HP:0008775)2.10882938
82Gingival bleeding (HP:0000225)2.10820830
83Spondylolisthesis (HP:0003302)2.10406264
84Interstitial pulmonary disease (HP:0006530)2.09172819
85Stomatitis (HP:0010280)2.08747282
86Leukocytosis (HP:0001974)2.07692557
87Abnormality of the peritoneum (HP:0002585)2.07156807
88Recurrent lower respiratory tract infections (HP:0002783)2.06153962
89Abnormality of T cell physiology (HP:0011840)2.05589328
90Restrictive lung disease (HP:0002091)2.05372420
91Prostate neoplasm (HP:0100787)2.03173778
92Neoplasm of the tracheobronchial system (HP:0100552)2.01183266
93Joint swelling (HP:0001386)1.99666911
94Subacute progressive viral hepatitis (HP:0006572)1.99587075
95Aplasia/Hypoplasia involving the sinuses (HP:0009120)1.98886234
96Long eyelashes (HP:0000527)1.97290305
97Peritonitis (HP:0002586)1.96119506
98Abnormality of eosinophils (HP:0001879)1.95553887
99Osteolytic defects of the hand bones (HP:0009699)1.94858757
100Osteolytic defects of the phalanges of the hand (HP:0009771)1.94858757
101Asymmetry of the thorax (HP:0001555)1.94822411
102Increased IgM level (HP:0003496)1.94382894
103Prominent nose (HP:0000448)1.93431823
104Sepsis (HP:0100806)1.92529449
105IgG deficiency (HP:0004315)1.92462576
106Hypoplasia of the thymus (HP:0000778)1.92286970
107Keratoconjunctivitis sicca (HP:0001097)1.92013324
108Acute hepatic failure (HP:0006554)1.91246130
109Anorexia (HP:0002039)1.89243875
110Viral hepatitis (HP:0006562)1.87688593
111Leukopenia (HP:0001882)1.87257001
112Granulocytopenia (HP:0001913)1.86778999
113Keratoconjunctivitis (HP:0001096)1.86698351
114Severe combined immunodeficiency (HP:0004430)1.85918484
115Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.84424528
116Lymphoma (HP:0002665)1.84237499
117Thick nail (HP:0001805)1.84023005
118Vertigo (HP:0002321)1.83410164
119Encephalitis (HP:0002383)1.82969116
120Skin ulcer (HP:0200042)1.82901296
121Limited elbow extension (HP:0001377)1.81956085
122Urethral obstruction (HP:0000796)1.81884476
123Hemoptysis (HP:0002105)1.81853700
124Glomerulopathy (HP:0100820)1.81615485
125Skin rash (HP:0000988)1.78815219
126Alveolar cell carcinoma (HP:0006519)1.76965393
127Thrombophlebitis (HP:0004418)1.76227694

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K13.99801342
2STK102.69486042
3RIPK42.58392472
4PRPF4B2.56790079
5TYK22.50925964
6MAP3K142.49795393
7TAOK32.40915576
8MAP3K132.35691733
9JAK32.29874603
10CAMK1D2.14585215
11KIT2.09294641
12BMPR22.07672168
13JAK12.07281100
14TXK1.97710418
15CDK121.97482104
16CAMK1G1.88904640
17IKBKE1.80674179
18FGFR31.79489510
19TGFBR21.79015935
20IRAK41.77794011
21TEC1.74297499
22ITK1.73897260
23TBK11.72895264
24CSF1R1.71842957
25MAP3K101.68696898
26SIK21.66319682
27BLK1.66142918
28EPHB11.54752735
29HCK1.52986529
30SYK1.52528283
31CSK1.51918858
32FGFR41.51705532
33BTK1.51044713
34ZAP701.44403357
35IKBKB1.39102851
36EEF2K1.33145253
37TRPM71.31870187
38RIPK11.30668697
39CHUK1.29665793
40NUAK11.28728141
41PIK3CG1.25291443
42* LCK1.20989112
43MARK31.18901219
44DMPK1.18146098
45MAP3K21.14548883
46IRAK11.12698126
47GRK61.12470674
48LRRK21.11160249
49MAP3K11.05379716
50MAP3K31.03978042
51CDC42BPA1.03336446
52IRAK31.01512804
53FES1.01388105
54PIM10.99841752
55CDK90.99079971
56PDGFRB0.98138381
57TTN0.96743587
58FRK0.96435802
59CDK60.95088779
60BRD40.94925530
61CLK10.94455136
62PTK60.92093208
63LYN0.91527951
64ERN10.89906938
65PRKCQ0.88623496
66NLK0.88386874
67SGK20.88139447
68YES10.86697845
69JAK20.86537795
70NEK90.86071243
71STK40.84183262
72MAP3K60.82369896
73MAP3K70.82368166
74CAMKK20.81945154
75HIPK20.80100163
76TRIB30.75783690
77STK30.72971309
78PDK10.69548876
79MAPK70.69494121
80TNK20.69057039
81KSR20.67268609
82MST40.65675145
83MAPK120.65594564
84PRKAA20.65272217
85EPHA30.64889223
86IRAK20.63618067
87RPS6KA40.63300004
88PKN20.62827177
89FGR0.62280420
90PRKCH0.61269467
91MATK0.60943109
92CAMKK10.60509768
93EGFR0.60167426
94INSRR0.60133523
95RET0.57689004
96ABL10.56575355
97PTK2B0.56200411
98CDK40.55027593
99SIK30.54974025
100ATR0.54900862
101ALK0.54861832
102SGK30.54124668
103FGFR20.53737674
104STK240.51228255
105STK380.50079880
106MAP3K50.49626517
107NEK20.49465764
108MAPK110.48550326
109WNK10.48357269
110MAP2K30.47995694
111FLT30.46171903
112SCYL20.46046529
113MELK0.45293783
114RAF10.44638823
115MAP3K80.41308849
116STK110.40589219
117TIE10.39060105
118RPS6KC10.37111078
119RPS6KL10.37111078
120IGF1R0.35851841
121MAPKAPK20.35246099
122MTOR0.33202661
123INSR0.33015443
124PDPK10.32542377
125RPS6KA60.32122393
126PRKD20.31373878
127* FYN0.31294827
128GRK70.31212115
129BMX0.30409280
130MARK20.30135247
131TAOK10.29517612

Predicted pathways (KEGG)

RankGene SetZ-score
1B cell receptor signaling pathway_Homo sapiens_hsa046622.98353839
2Primary immunodeficiency_Homo sapiens_hsa053402.95541437
3NF-kappa B signaling pathway_Homo sapiens_hsa040642.55492594
4Osteoclast differentiation_Homo sapiens_hsa043802.40694543
5Leishmaniasis_Homo sapiens_hsa051402.36695368
6Hematopoietic cell lineage_Homo sapiens_hsa046401.99436315
7Type I diabetes mellitus_Homo sapiens_hsa049401.98804414
8Intestinal immune network for IgA production_Homo sapiens_hsa046721.94864235
9Measles_Homo sapiens_hsa051621.91860762
10T cell receptor signaling pathway_Homo sapiens_hsa046601.85679523
11Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.78569828
12Toll-like receptor signaling pathway_Homo sapiens_hsa046201.75685871
13Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.74220483
14NOD-like receptor signaling pathway_Homo sapiens_hsa046211.66639151
15Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.66146594
16Toxoplasmosis_Homo sapiens_hsa051451.62867079
17Leukocyte transendothelial migration_Homo sapiens_hsa046701.48595201
18Chemokine signaling pathway_Homo sapiens_hsa040621.48083107
19Jak-STAT signaling pathway_Homo sapiens_hsa046301.47351107
20Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.46315847
21Antigen processing and presentation_Homo sapiens_hsa046121.45674225
22RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.45038733
23Chronic myeloid leukemia_Homo sapiens_hsa052201.44742767
24Tuberculosis_Homo sapiens_hsa051521.42198883
25TNF signaling pathway_Homo sapiens_hsa046681.40671687
26Hepatitis B_Homo sapiens_hsa051611.34565736
27Staphylococcus aureus infection_Homo sapiens_hsa051501.34268443
28Pancreatic cancer_Homo sapiens_hsa052121.33514720
29Influenza A_Homo sapiens_hsa051641.32767260
30Acute myeloid leukemia_Homo sapiens_hsa052211.32667957
31Platelet activation_Homo sapiens_hsa046111.31401017
32Herpes simplex infection_Homo sapiens_hsa051681.27146613
33Transcriptional misregulation in cancer_Homo sapiens_hsa052021.26006302
34Non-homologous end-joining_Homo sapiens_hsa034501.22414186
35Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.21396986
36Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.17759672
37Apoptosis_Homo sapiens_hsa042101.16282128
38Allograft rejection_Homo sapiens_hsa053301.15835160
39Small cell lung cancer_Homo sapiens_hsa052221.14954294
40Pertussis_Homo sapiens_hsa051331.14549539
41Viral myocarditis_Homo sapiens_hsa054161.13066529
42Shigellosis_Homo sapiens_hsa051311.12172544
43Malaria_Homo sapiens_hsa051441.11323489
44Rheumatoid arthritis_Homo sapiens_hsa053231.10054949
45AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.06887662
46Dorso-ventral axis formation_Homo sapiens_hsa043201.00091446
47Lysine degradation_Homo sapiens_hsa003100.99620164
48Non-small cell lung cancer_Homo sapiens_hsa052230.99257918
49Hepatitis C_Homo sapiens_hsa051600.96219171
50Graft-versus-host disease_Homo sapiens_hsa053320.95031473
51Phosphatidylinositol signaling system_Homo sapiens_hsa040700.93880127
52Salmonella infection_Homo sapiens_hsa051320.93214729
53MicroRNAs in cancer_Homo sapiens_hsa052060.92469023
54Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.91301234
55Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.90974835
56Phagosome_Homo sapiens_hsa041450.88772232
57Viral carcinogenesis_Homo sapiens_hsa052030.87699017
58Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.87481733
59Prolactin signaling pathway_Homo sapiens_hsa049170.85854610
60Neurotrophin signaling pathway_Homo sapiens_hsa047220.84515432
61Legionellosis_Homo sapiens_hsa051340.81177599
62Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.79176336
63Regulation of actin cytoskeleton_Homo sapiens_hsa048100.78671139
64HTLV-I infection_Homo sapiens_hsa051660.77416086
65African trypanosomiasis_Homo sapiens_hsa051430.75251001
66Prostate cancer_Homo sapiens_hsa052150.74272645
67VEGF signaling pathway_Homo sapiens_hsa043700.74159793
68Inositol phosphate metabolism_Homo sapiens_hsa005620.72751098
69Thyroid hormone signaling pathway_Homo sapiens_hsa049190.72653560
70FoxO signaling pathway_Homo sapiens_hsa040680.71891550
71Carbohydrate digestion and absorption_Homo sapiens_hsa049730.70462709
72Proteoglycans in cancer_Homo sapiens_hsa052050.70136015
73Insulin resistance_Homo sapiens_hsa049310.68973442
74Adherens junction_Homo sapiens_hsa045200.67514729
75Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.66934049
76Autoimmune thyroid disease_Homo sapiens_hsa053200.66886251
77GnRH signaling pathway_Homo sapiens_hsa049120.66562037
78Focal adhesion_Homo sapiens_hsa045100.66228663
79Amoebiasis_Homo sapiens_hsa051460.64821737
80Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.64530123
81SNARE interactions in vesicular transport_Homo sapiens_hsa041300.62636469
82Lysosome_Homo sapiens_hsa041420.62583553
83Asthma_Homo sapiens_hsa053100.62134556
84Type II diabetes mellitus_Homo sapiens_hsa049300.61861283
85Other glycan degradation_Homo sapiens_hsa005110.61004874
86Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.60939120
87Renal cell carcinoma_Homo sapiens_hsa052110.60577637
88ABC transporters_Homo sapiens_hsa020100.60370771
89Colorectal cancer_Homo sapiens_hsa052100.60049705
90Glioma_Homo sapiens_hsa052140.58668345
91Epstein-Barr virus infection_Homo sapiens_hsa051690.57872624
92Notch signaling pathway_Homo sapiens_hsa043300.57785115
93Sphingolipid signaling pathway_Homo sapiens_hsa040710.57424657
94mTOR signaling pathway_Homo sapiens_hsa041500.57118737
95Endocytosis_Homo sapiens_hsa041440.56913635
96Phospholipase D signaling pathway_Homo sapiens_hsa040720.56820334
97ErbB signaling pathway_Homo sapiens_hsa040120.55652520
98Caffeine metabolism_Homo sapiens_hsa002320.55619891
99Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.54794916
100MAPK signaling pathway_Homo sapiens_hsa040100.53748117
101Choline metabolism in cancer_Homo sapiens_hsa052310.53460710
102Long-term potentiation_Homo sapiens_hsa047200.53399039
103Glycosaminoglycan degradation_Homo sapiens_hsa005310.52777592
104Rap1 signaling pathway_Homo sapiens_hsa040150.51817640
105HIF-1 signaling pathway_Homo sapiens_hsa040660.50961561
106p53 signaling pathway_Homo sapiens_hsa041150.49501079
107Pathways in cancer_Homo sapiens_hsa052000.48269440
108Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.48229378
109Endometrial cancer_Homo sapiens_hsa052130.47658995
110Adipocytokine signaling pathway_Homo sapiens_hsa049200.46452436
111Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.43478669
112Regulation of autophagy_Homo sapiens_hsa041400.42087782
113Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.37202787
114Longevity regulating pathway - mammal_Homo sapiens_hsa042110.34374554
115Glycerophospholipid metabolism_Homo sapiens_hsa005640.33299074

Most similar genes based on co-expression Upload to Enrichr

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