IVD

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Isovaleryl-CoA dehydrogenase (IVD) is a mitochondrial matrix enzyme that catalyzes the third step in leucine catabolism. The genetic deficiency of IVD results in an accumulation of isovaleric acid, which is toxic to the central nervous system and leads to isovaleric acidemia. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1L-phenylalanine catabolic process (GO:0006559)6.26126857
2erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)6.26126857
3L-phenylalanine metabolic process (GO:0006558)6.02483923
4erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)6.02483923
5aromatic amino acid family catabolic process (GO:0009074)5.62275032
6glyoxylate metabolic process (GO:0046487)5.49964520
7lysine metabolic process (GO:0006553)5.43402433
8lysine catabolic process (GO:0006554)5.43402433
9omega-hydroxylase P450 pathway (GO:0097267)5.13991037
10sulfur amino acid catabolic process (GO:0000098)5.08560536
11tryptophan catabolic process (GO:0006569)5.06879506
12indole-containing compound catabolic process (GO:0042436)5.06879506
13indolalkylamine catabolic process (GO:0046218)5.06879506
14kynurenine metabolic process (GO:0070189)5.05280157
15cysteine metabolic process (GO:0006534)4.90256704
16alpha-linolenic acid metabolic process (GO:0036109)4.83291508
17valine metabolic process (GO:0006573)4.81442152
18tryptophan metabolic process (GO:0006568)4.81356190
19fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.80702274
20short-chain fatty acid metabolic process (GO:0046459)4.69221304
21cellular modified amino acid catabolic process (GO:0042219)4.67241127
22fatty acid beta-oxidation (GO:0006635)4.66177580
23biotin metabolic process (GO:0006768)4.63121636
24triglyceride-rich lipoprotein particle remodeling (GO:0034370)4.61357891
25bile acid biosynthetic process (GO:0006699)4.60105227
26amino-acid betaine metabolic process (GO:0006577)4.56859273
27coenzyme catabolic process (GO:0009109)4.56323093
28L-serine metabolic process (GO:0006563)4.53535318
292-oxoglutarate metabolic process (GO:0006103)4.51528055
30oxidative demethylation (GO:0070989)4.48682076
31homocysteine metabolic process (GO:0050667)4.47477413
32ethanol metabolic process (GO:0006067)4.41097537
33* branched-chain amino acid catabolic process (GO:0009083)4.38615692
34serine family amino acid catabolic process (GO:0009071)4.37316574
35fatty acid oxidation (GO:0019395)4.32294869
36aspartate family amino acid catabolic process (GO:0009068)4.31198698
37cellular ketone body metabolic process (GO:0046950)4.28560262
38acetyl-CoA metabolic process (GO:0006084)4.27319228
39lipid oxidation (GO:0034440)4.25457398
40fatty acid catabolic process (GO:0009062)4.22395836
41* alpha-amino acid catabolic process (GO:1901606)4.18623668
42* branched-chain amino acid metabolic process (GO:0009081)4.17605877
43* cellular amino acid catabolic process (GO:0009063)4.11738283
44regulation of triglyceride catabolic process (GO:0010896)4.09284724
45monocarboxylic acid catabolic process (GO:0072329)4.06728216
46aromatic amino acid family metabolic process (GO:0009072)4.06419523
47complement activation, alternative pathway (GO:0006957)3.99353106
48carnitine metabolic process (GO:0009437)3.97344103
49urea cycle (GO:0000050)3.96530070
50urea metabolic process (GO:0019627)3.96530070
51fatty acid transmembrane transport (GO:1902001)3.92817036
52ethanol oxidation (GO:0006069)3.91421919
53* organic acid catabolic process (GO:0016054)3.89952931
54* carboxylic acid catabolic process (GO:0046395)3.89952931
55bile acid metabolic process (GO:0008206)3.87334297
56glucuronate metabolic process (GO:0019585)3.86881329
57uronic acid metabolic process (GO:0006063)3.86881329
58proline metabolic process (GO:0006560)3.86752810
59serine family amino acid biosynthetic process (GO:0009070)3.84974493
60S-adenosylmethionine metabolic process (GO:0046500)3.82270220
61triglyceride homeostasis (GO:0070328)3.81735519
62acylglycerol homeostasis (GO:0055090)3.81735519
63tyrosine metabolic process (GO:0006570)3.77014543
64amino acid salvage (GO:0043102)3.76619876
65L-methionine salvage (GO:0071267)3.76619876
66L-methionine biosynthetic process (GO:0071265)3.76619876
67peptidyl-glutamic acid carboxylation (GO:0017187)3.76408930
68protein carboxylation (GO:0018214)3.76408930
69glutamate metabolic process (GO:0006536)3.76158284
70drug transmembrane transport (GO:0006855)3.75184955
71nitrogen cycle metabolic process (GO:0071941)3.71452333
72high-density lipoprotein particle remodeling (GO:0034375)3.71400664
73carnitine shuttle (GO:0006853)3.71082412
74epoxygenase P450 pathway (GO:0019373)3.70374922
75ketone body metabolic process (GO:1902224)3.67042554
76drug catabolic process (GO:0042737)3.65687296
77dicarboxylic acid biosynthetic process (GO:0043650)3.65012704
78regulation of sequestering of triglyceride (GO:0010889)3.64431097
79regulation of protein activation cascade (GO:2000257)3.61128374
80tricarboxylic acid metabolic process (GO:0072350)3.60345365
81indolalkylamine metabolic process (GO:0006586)3.59913976
82positive regulation of fatty acid beta-oxidation (GO:0032000)3.55464548
83negative regulation of fibrinolysis (GO:0051918)3.52578636
84oxaloacetate metabolic process (GO:0006107)3.50445367
85urate metabolic process (GO:0046415)3.50011305
86proline biosynthetic process (GO:0006561)3.49997991
87serine family amino acid metabolic process (GO:0009069)3.48203383
88benzene-containing compound metabolic process (GO:0042537)3.48081037
89amine catabolic process (GO:0009310)3.47633298
90cellular biogenic amine catabolic process (GO:0042402)3.47633298
91regulation of fibrinolysis (GO:0051917)3.47283455
92plasma lipoprotein particle clearance (GO:0034381)3.47045284
93blood coagulation, intrinsic pathway (GO:0007597)3.44291418
94drug metabolic process (GO:0017144)3.42722053
95phenylpropanoid metabolic process (GO:0009698)3.42011491
96regulation of complement activation (GO:0030449)3.39605281
97protein-lipid complex remodeling (GO:0034368)3.38154341
98macromolecular complex remodeling (GO:0034367)3.38154341
99plasma lipoprotein particle remodeling (GO:0034369)3.38154341
100phospholipid homeostasis (GO:0055091)3.36783852
101reverse cholesterol transport (GO:0043691)3.34757035
102aminoglycoside antibiotic metabolic process (GO:0030647)3.33025320
103regulation of cholesterol esterification (GO:0010872)3.31938658
104exogenous drug catabolic process (GO:0042738)3.31120414
105* small molecule catabolic process (GO:0044282)3.30755950
106quaternary ammonium group transport (GO:0015697)3.29502819
107cofactor catabolic process (GO:0051187)3.28686777
108amino-acid betaine transport (GO:0015838)3.28442883
109carnitine transport (GO:0015879)3.28442883
110imidazole-containing compound metabolic process (GO:0052803)3.27602222
111water-soluble vitamin biosynthetic process (GO:0042364)3.27253947
112positive regulation of lipid catabolic process (GO:0050996)3.24089820
113positive regulation of fatty acid oxidation (GO:0046321)3.23779983
114quinone biosynthetic process (GO:1901663)3.21540476
115glycine metabolic process (GO:0006544)3.20771416
116regulation of bile acid biosynthetic process (GO:0070857)3.19434489
117arginine metabolic process (GO:0006525)3.18787693
118aldehyde catabolic process (GO:0046185)3.18761731
119NADH metabolic process (GO:0006734)3.17102817
120tricarboxylic acid cycle (GO:0006099)3.17038506
121cellular glucuronidation (GO:0052695)3.15400638
122response to mercury ion (GO:0046689)3.15317211
123flavonoid metabolic process (GO:0009812)3.13083999
124regulation of cholesterol metabolic process (GO:0090181)3.12786313
125sulfur amino acid biosynthetic process (GO:0000097)3.07818626
126alkaloid metabolic process (GO:0009820)3.07706134
127negative regulation of sterol transport (GO:0032372)3.07420376
128negative regulation of cholesterol transport (GO:0032375)3.07420376
129response to misfolded protein (GO:0051788)3.03363515
130aspartate family amino acid metabolic process (GO:0009066)2.95073304
131glutamine family amino acid biosynthetic process (GO:0009084)2.94288671
132regulation of plasminogen activation (GO:0010755)2.93838125
133methionine biosynthetic process (GO:0009086)2.92981070
134dicarboxylic acid metabolic process (GO:0043648)2.91418714
135regulation of cholesterol biosynthetic process (GO:0045540)2.90520046
136response to nitrosative stress (GO:0051409)2.86520338

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse9.38218297
2PPARG_19300518_ChIP-PET_3T3-L1_Mouse6.96287606
3RXR_22158963_ChIP-Seq_LIVER_Mouse6.80105345
4PPARA_22158963_ChIP-Seq_LIVER_Mouse5.84056685
5LXR_22158963_ChIP-Seq_LIVER_Mouse5.46563338
6EGR1_23403033_ChIP-Seq_LIVER_Mouse4.88058238
7FOXO1_23066095_ChIP-Seq_LIVER_Mouse4.58593819
8E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse4.25249641
9NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.87497966
10CEBPA_23403033_ChIP-Seq_LIVER_Mouse3.38884294
11TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse3.00453453
12CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human2.65436081
13TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.60181698
14CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.58795757
15JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.43398449
16ESR1_15608294_ChIP-ChIP_MCF-7_Human2.10148872
17* SRF_21415370_ChIP-Seq_HL-1_Mouse2.03581459
18TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.92401422
19ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.85775437
20BP1_19119308_ChIP-ChIP_Hs578T_Human1.85071577
21NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.84805173
22TET1_21451524_ChIP-Seq_MESCs_Mouse1.77825264
23HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.76393687
24PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.72879476
25TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.69115410
26NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.67225510
27CLOCK_20551151_ChIP-Seq_293T_Human1.59169289
28MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.51951944
29FOXP1_21924763_ChIP-Seq_HESCs_Human1.51416235
30BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.51188233
31ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.50294310
32HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.49665469
33FOXA2_19822575_ChIP-Seq_HepG2_Human1.49398146
34MYC_18358816_ChIP-ChIP_MESCs_Mouse1.48560908
35XRN2_22483619_ChIP-Seq_HELA_Human1.47513110
36GATA1_22025678_ChIP-Seq_K562_Human1.42741012
37RARB_24833708_ChIP-Seq_LIVER_Mouse1.42238600
38KDM5A_27292631_Chip-Seq_BREAST_Human1.39606808
39E2F1_20622854_ChIP-Seq_HELA_Human1.38757328
40YY1_21170310_ChIP-Seq_MESCs_Mouse1.36638490
41GABP_19822575_ChIP-Seq_HepG2_Human1.35616219
42THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.35283477
43ESR2_21235772_ChIP-Seq_MCF-7_Human1.34576822
44ELF1_20517297_ChIP-Seq_JURKAT_Human1.34085633
45PHF8_20622854_ChIP-Seq_HELA_Human1.33580931
46ETS1_20019798_ChIP-Seq_JURKAT_Human1.33536023
47CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.32754291
48PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.31092289
49DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.28923822
50ERA_21632823_ChIP-Seq_H3396_Human1.28227333
51CTCF_18555785_ChIP-Seq_MESCs_Mouse1.27524654
52* HNF4A_19822575_ChIP-Seq_HepG2_Human1.23305602
53STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.23281198
54NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.21614507
55RARA_24833708_ChIP-Seq_LIVER_Mouse1.20707028
56BCL6_27268052_Chip-Seq_Bcells_Human1.20543271
57PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.19627121
58SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.19611306
59CIITA_25753668_ChIP-Seq_RAJI_Human1.19010757
60ZNF274_21170338_ChIP-Seq_K562_Hela1.17495746
61TBX20_22328084_ChIP-Seq_HEART_Mouse1.17200052
62TBX20_22080862_ChIP-Seq_HEART_Mouse1.17200052
63RARG_19884340_ChIP-ChIP_MEFs_Mouse1.16935340
64DNAJC2_21179169_ChIP-ChIP_NT2_Human1.16762868
65EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.16585305
66* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.16220215
67* ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.15166542
68CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.13673258
69ESR1_21235772_ChIP-Seq_MCF-7_Human1.11845230
70SA1_27219007_Chip-Seq_ERYTHROID_Human1.11521366
71* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.11310914
72CTCF_20526341_ChIP-Seq_ESCs_Human1.10946671
73ESR1_20079471_ChIP-ChIP_T-47D_Human1.08229953
74BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.06979865
75TFAP2A_17053090_ChIP-ChIP_MCF-7_Human1.06975124
76TBX5_21415370_ChIP-Seq_HL-1_Mouse1.06462449
77HTT_18923047_ChIP-ChIP_STHdh_Human1.06446259
78THAP11_20581084_ChIP-Seq_MESCs_Mouse1.05906415
79GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.04320004
80MYC_18555785_ChIP-Seq_MESCs_Mouse1.03929089
81SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.03319085
82* CREB1_26743006_Chip-Seq_LNCaP_Human1.02827734
83* SA1_27219007_Chip-Seq_Bcells_Human1.02711270
84SOX2_27498859_Chip-Seq_STOMACH_Mouse1.01274596
85YY1_22570637_ChIP-Seq_MALME-3M_Human1.01014141
86SETDB1_19884255_ChIP-Seq_MESCs_Mouse1.00769418
87DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.00613355
88CTCF_26484167_Chip-Seq_Bcells_Mouse0.98897272
89KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human0.98397989
90ETS1_21867929_ChIP-Seq_TH2_Mouse0.98284138
91EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.97598158
92EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse0.97565076
93RXRA_24833708_ChIP-Seq_LIVER_Mouse0.97185751
94SMC3_22415368_ChIP-Seq_MEFs_Mouse0.96142311
95ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.95585759
96MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.94309193
97NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse0.94130822
98DROSHA_22980978_ChIP-Seq_HELA_Human0.94073210
99KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.93974411
100KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.93974411
101KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.93974411
102* RAC3_21632823_ChIP-Seq_H3396_Human0.93502985
103CDX2_20551321_ChIP-Seq_CACO-2_Human0.93389807
104PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.93335365
105BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.91269927
106* OCT4_20526341_ChIP-Seq_ESCs_Human0.91119289
107LXR_22292898_ChIP-Seq_THP-1_Human0.91103066
108CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.89956538
109AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.88770367
110GATA4_25053715_ChIP-Seq_YYC3_Human0.86264928
111FOXO3_23340844_ChIP-Seq_DLD1_Human0.85921178
112PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.85828834
113EP300_21415370_ChIP-Seq_HL-1_Mouse0.85210301
114ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.83991769
115STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.83901931
116AUTS2_25519132_ChIP-Seq_293T-REX_Human0.83686115
117ESET_19884257_ChIP-Seq_ESCs_Mouse0.76220874
118RAD21_21589869_ChIP-Seq_MESCs_Mouse0.75459964
119SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.73528639
120STAT3_1855785_ChIP-Seq_MESCs_Mouse0.72057918
121ERG_21242973_ChIP-ChIP_JURKAT_Human0.72056475
122TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.70460129
123P63_20808887_ChIP-Seq_KERATINOCYTES_Human0.68578663
124ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.68513649
125SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.66397372
126TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.64129524
127PPAR_26484153_Chip-Seq_NCI-H1993_Human0.62915230
128CSB_26484114_Chip-Seq_FIBROBLAST_Human0.62883174
129PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.62098172
130SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.61829616
131SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.61411714
132PIAS1_25552417_ChIP-Seq_VCAP_Human0.61211259
133CEBPB_22108803_ChIP-Seq_LS180_Human0.61092859
134MYC_27129775_Chip-Seq_CORNEA_Mouse0.61046361
135FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.60829495
136CTCF_27219007_Chip-Seq_Bcells_Human0.60608730
137TP63_22573176_ChIP-Seq_HFKS_Human0.59406716
138GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.59146410
139TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.58984176
140FOXA1_25552417_ChIP-Seq_VCAP_Human0.58489554
141* NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.58290161
142* NRF2_20460467_ChIP-Seq_MEFs_Mouse0.58290161
143PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.58042483
144AR_20517297_ChIP-Seq_VCAP_Human0.57959149
145RACK7_27058665_Chip-Seq_MCF-7_Human0.57797240
146SMC4_20622854_ChIP-Seq_HELA_Human0.57336541
147P63_26484246_Chip-Seq_KERATINOCYTES_Human0.56575463
148PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.56150380
149IRF1_19129219_ChIP-ChIP_H3396_Human0.56005040
150NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.55388991
151ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.54694575
152SMAD4_21741376_ChIP-Seq_HESCs_Human0.53854714
153GATA3_24758297_ChIP-Seq_MCF-7_Human0.53478599
154STAT3_19079543_ChIP-ChIP_MESCs_Mouse0.53017413
155SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.52578879
156CDX2_19796622_ChIP-Seq_MESCs_Mouse0.52066176
157BCOR_27268052_Chip-Seq_Bcells_Human0.51836780
158CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.51721239
159CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.51164002
160CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.50950196
161FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.50602275
162BCAT_22108803_ChIP-Seq_LS180_Human0.50041001
163ERG_20517297_ChIP-Seq_VCAP_Human0.49899867
164P68_20966046_ChIP-Seq_HELA_Human0.49797810
165SETDB1_19884257_ChIP-Seq_MESCs_Mouse0.48251573

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system6.50267798
2MP0005360_urolithiasis6.27280200
3MP0005365_abnormal_bile_salt5.12702659
4MP0005085_abnormal_gallbladder_physiolo5.03717041
5MP0008875_abnormal_xenobiotic_pharmacok4.20355554
6MP0003252_abnormal_bile_duct3.53315109
7MP0003806_abnormal_nucleotide_metabolis3.13160346
8MP0010329_abnormal_lipoprotein_level3.07718423
9MP0005332_abnormal_amino_acid3.06232661
10MP0003195_calcinosis3.02087453
11MP0003136_yellow_coat_color2.98211024
12MP0002837_dystrophic_cardiac_calcinosis2.87946202
13MP0005670_abnormal_white_adipose2.56254616
14MP0005083_abnormal_biliary_tract2.45149693
15MP0003011_delayed_dark_adaptation2.28236483
16MP0004019_abnormal_vitamin_homeostasis2.26281199
17MP0002138_abnormal_hepatobiliary_system2.18987893
18MP0004043_abnormal_pH_regulation2.15954254
19MP0002118_abnormal_lipid_homeostasis2.12259875
20MP0009840_abnormal_foam_cell2.08729839
21MP0001666_abnormal_nutrient_absorption2.07297712
22MP0004130_abnormal_muscle_cell1.95465023
23MP0002249_abnormal_larynx_morphology1.93984866
24MP0005319_abnormal_enzyme/_coenzyme1.88418520
25MP0001986_abnormal_taste_sensitivity1.87255674
26MP0000609_abnormal_liver_physiology1.86664255
27MP0003191_abnormal_cellular_cholesterol1.86573908
28MP0005646_abnormal_pituitary_gland1.86214719
29MP0005666_abnormal_adipose_tissue1.79920170
30MP0009643_abnormal_urine_homeostasis1.74007273
31MP0003646_muscle_fatigue1.73388897
32MP0006036_abnormal_mitochondrial_physio1.71148611
33MP0004858_abnormal_nervous_system1.66315191
34MP0002254_reproductive_system_inflammat1.63467667
35MP0005584_abnormal_enzyme/coenzyme_acti1.59429237
36MP0002736_abnormal_nociception_after1.57348173
37MP0003186_abnormal_redox_activity1.51065062
38MP0001968_abnormal_touch/_nociception1.50478552
39MP0000566_synostosis1.46378300
40MP0005330_cardiomyopathy1.40032401
41MP0005451_abnormal_body_composition1.39508554
42MP0001764_abnormal_homeostasis1.33256716
43MP0002971_abnormal_brown_adipose1.30744135
44MP0009384_cardiac_valve_regurgitation1.29905711
45MP0006035_abnormal_mitochondrial_morpho1.26273639
46MP0002078_abnormal_glucose_homeostasis1.23882860
47MP0004133_heterotaxia1.21197862
48MP0004145_abnormal_muscle_electrophysio1.19656489
49MP0004215_abnormal_myocardial_fiber1.18921140
50MP0000749_muscle_degeneration1.18361108
51MP0005535_abnormal_body_temperature1.17386410
52MP0003705_abnormal_hypodermis_morpholog1.17292261
53MP0002653_abnormal_ependyma_morphology1.16347367
54MP0005551_abnormal_eye_electrophysiolog1.16336359
55MP0004782_abnormal_surfactant_physiolog1.16097451
56MP0008789_abnormal_olfactory_epithelium1.14982243
57MP0003868_abnormal_feces_composition1.13645291
58MP0005636_abnormal_mineral_homeostasis1.12707955
59MP0004036_abnormal_muscle_relaxation1.12110534
60MP0004233_abnormal_muscle_weight1.10452507
61MP0004084_abnormal_cardiac_muscle1.10146968
62MP0002332_abnormal_exercise_endurance1.09357560
63MP0005334_abnormal_fat_pad1.06388646
64MP0001756_abnormal_urination1.06192915
65MP0008872_abnormal_physiological_respon1.06128128
66MP0005375_adipose_tissue_phenotype1.04571898
67MP0000751_myopathy1.00484245
68MP0008961_abnormal_basal_metabolism0.99305994
69MP0004185_abnormal_adipocyte_glucose0.98843405
70MP0005647_abnormal_sex_gland0.98581518
71MP0003137_abnormal_impulse_conducting0.97259214
72MP0000538_abnormal_urinary_bladder0.97196955
73MP0002269_muscular_atrophy0.96330014
74MP0005266_abnormal_metabolism0.96149259
75MP0002876_abnormal_thyroid_physiology0.94126676
76MP0005394_taste/olfaction_phenotype0.90640279
77MP0005499_abnormal_olfactory_system0.90640279
78MP0005645_abnormal_hypothalamus_physiol0.89703826
79MP0001765_abnormal_ion_homeostasis0.89106960
80MP0002972_abnormal_cardiac_muscle0.89017883
81MP0005620_abnormal_muscle_contractility0.88885821
82MP0002638_abnormal_pupillary_reflex0.88561363
83MP0001529_abnormal_vocalization0.87215445
84MP0004087_abnormal_muscle_fiber0.86563330
85MP0003718_maternal_effect0.85530082
86MP0000598_abnormal_liver_morphology0.85368274
87MP0010368_abnormal_lymphatic_system0.83604558
88MP0002970_abnormal_white_adipose0.81537381
89MP0008775_abnormal_heart_ventricle0.81416176
90MP0000230_abnormal_systemic_arterial0.81407463
91MP0009642_abnormal_blood_homeostasis0.81368310
92MP0001661_extended_life_span0.79757624
93MP0004264_abnormal_extraembryonic_tissu0.78864935
94MP0009115_abnormal_fat_cell0.78749331
95MP0001502_abnormal_circadian_rhythm0.77745477
96MP0005376_homeostasis/metabolism_phenot0.76783313
97MP0003690_abnormal_glial_cell0.76001100
98MP0006138_congestive_heart_failure0.75541151
99MP0005423_abnormal_somatic_nervous0.75243661
100MP0005448_abnormal_energy_balance0.74990148
101MP0009780_abnormal_chondrocyte_physiolo0.74477846
102MP0003879_abnormal_hair_cell0.74286730
103MP0005385_cardiovascular_system_phenoty0.74186787
104MP0001544_abnormal_cardiovascular_syste0.74186787
105MP0009764_decreased_sensitivity_to0.73984491
106MP0002136_abnormal_kidney_physiology0.72173226
107MP0002938_white_spotting0.72136865
108MP0005395_other_phenotype0.71648401
109MP0002909_abnormal_adrenal_gland0.71384068
110MP0002735_abnormal_chemical_nociception0.70386790
111MP0009763_increased_sensitivity_to0.69886033
112MP0002928_abnormal_bile_duct0.69875822
113MP0001881_abnormal_mammary_gland0.69515345
114MP0000537_abnormal_urethra_morphology0.68056457
115MP0004147_increased_porphyrin_level0.67761851
116MP0001485_abnormal_pinna_reflex0.66463155
117MP0010030_abnormal_orbit_morphology0.66277658
118MP0003953_abnormal_hormone_level0.65713517
119MP0010630_abnormal_cardiac_muscle0.64921755
120MP0002127_abnormal_cardiovascular_syste0.64837638
121MP0000750_abnormal_muscle_regeneration0.63079230
122MP0009672_abnormal_birth_weight0.61879401
123MP0004085_abnormal_heartbeat0.61068823
124MP0003221_abnormal_cardiomyocyte_apopto0.60739099
125MP0003656_abnormal_erythrocyte_physiolo0.59696578
126MP0008469_abnormal_protein_level0.58699468
127MP0003638_abnormal_response/metabolism_0.57772834
128MP0000013_abnormal_adipose_tissue0.57613852
129MP0005220_abnormal_exocrine_pancreas0.57355901
130MP0005452_abnormal_adipose_tissue0.56850586
131MP0002557_abnormal_social/conspecific_i0.56612957
132MP0000026_abnormal_inner_ear0.56359130
133MP0005084_abnormal_gallbladder_morpholo0.55778133
134MP0002108_abnormal_muscle_morphology0.55721994
135MP0002168_other_aberrant_phenotype0.55019610
136MP0009697_abnormal_copulation0.54860474
137MP0005165_increased_susceptibility_to0.54527073
138MP0003959_abnormal_lean_body0.54136434
139MP0000747_muscle_weakness0.53178898
140MP0004381_abnormal_hair_follicle0.50190813
141MP0000759_abnormal_skeletal_muscle0.49306958
142MP0002106_abnormal_muscle_physiology0.43666124
143MP0000003_abnormal_adipose_tissue0.42385387
144MP0008874_decreased_physiological_sensi0.40882510

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of aromatic amino acid family metabolism (HP:0004338)5.37698531
2Intrahepatic cholestasis (HP:0001406)5.24523529
3* Hyperglycinuria (HP:0003108)5.10279534
4* Ketosis (HP:0001946)5.00514708
5Hypoglycemic coma (HP:0001325)4.96996432
6Xanthomatosis (HP:0000991)4.77298312
7Hyperammonemia (HP:0001987)4.70731794
8* Ketoacidosis (HP:0001993)4.67127167
9Deep venous thrombosis (HP:0002625)4.65821949
10* Abnormality of serine family amino acid metabolism (HP:0010894)4.65331977
11* Abnormality of glycine metabolism (HP:0010895)4.65331977
12Hyperglycinemia (HP:0002154)4.41768958
13Abnormality of monocarboxylic acid metabolism (HP:0010996)4.25941441
14Abnormality of fatty-acid metabolism (HP:0004359)4.23757940
15Prolonged partial thromboplastin time (HP:0003645)4.15232880
16Hyperlipoproteinemia (HP:0010980)4.10665272
17Gout (HP:0001997)4.09329093
18Hyperinsulinemic hypoglycemia (HP:0000825)3.93715580
19Dicarboxylic aciduria (HP:0003215)3.90170460
20Abnormality of dicarboxylic acid metabolism (HP:0010995)3.90170460
21Abnormality of glutamine family amino acid metabolism (HP:0010902)3.80750380
22Complement deficiency (HP:0004431)3.69846027
23Hypoalphalipoproteinemia (HP:0003233)3.67196519
24Testicular atrophy (HP:0000029)3.65401911
25Abnormality of aspartate family amino acid metabolism (HP:0010899)3.53179727
26Hypobetalipoproteinemia (HP:0003563)3.48671510
27Generalized aminoaciduria (HP:0002909)3.45703739
28Myoglobinuria (HP:0002913)3.44115693
29Hypolipoproteinemia (HP:0010981)3.37066253
30Joint hemorrhage (HP:0005261)3.36798345
31Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.35869579
32Abnormality of sulfur amino acid metabolism (HP:0004339)3.30409898
33Abnormality of purine metabolism (HP:0004352)3.29832718
34Abnormality of the intrinsic pathway (HP:0010989)3.27597829
35Epidermoid cyst (HP:0200040)3.27386274
36Bile duct proliferation (HP:0001408)3.26993105
37Abnormal biliary tract physiology (HP:0012439)3.26993105
38* Metabolic acidosis (HP:0001942)3.26629868
39Abnormality of the level of lipoprotein cholesterol (HP:0010979)3.18341596
40Proximal tubulopathy (HP:0000114)3.16777348
41Opisthotonus (HP:0002179)3.08553901
42Abnormality of methionine metabolism (HP:0010901)3.01598061
43Delayed CNS myelination (HP:0002188)3.00894583
44Hyperuricemia (HP:0002149)2.99196528
45Increased purine levels (HP:0004368)2.99196528
46Abnormality of serum amino acid levels (HP:0003112)2.97250092
47Abnormality of nucleobase metabolism (HP:0010932)2.95789033
48* Lethargy (HP:0001254)2.92278626
49Cerebral edema (HP:0002181)2.88544055
50Hypochromic microcytic anemia (HP:0004840)2.88342862
51Skin nodule (HP:0200036)2.87596861
52Hypoglycemic seizures (HP:0002173)2.84870701
53Cerebral palsy (HP:0100021)2.81484641
54Fat malabsorption (HP:0002630)2.72251356
55Abnormality of the common coagulation pathway (HP:0010990)2.70297619
56* Vomiting (HP:0002013)2.67409777
57Calf muscle hypertrophy (HP:0008981)2.60901914
58Hypercholesterolemia (HP:0003124)2.57886201
59Abnormality of complement system (HP:0005339)2.55434705
60Hyperbilirubinemia (HP:0002904)2.52385747
61Muscle hypertrophy of the lower extremities (HP:0008968)2.52377049
62Enlarged kidneys (HP:0000105)2.49429489
63Conjugated hyperbilirubinemia (HP:0002908)2.46490477
64Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.42359281
65Abnormality of alanine metabolism (HP:0010916)2.42359281
66Hyperalaninemia (HP:0003348)2.42359281
67Late onset (HP:0003584)2.41712660
68Reduced antithrombin III activity (HP:0001976)2.39879334
69Abnormal cartilage morphology (HP:0002763)2.37000086
70Ventricular tachycardia (HP:0004756)2.35389664
71Exercise-induced myalgia (HP:0003738)2.34652237
72Ragged-red muscle fibers (HP:0003200)2.33966715
73Glycosuria (HP:0003076)2.31693057
74Abnormality of urine glucose concentration (HP:0011016)2.31693057
75Vascular calcification (HP:0004934)2.29482093
76Rhabdomyolysis (HP:0003201)2.28579485
77Renal cortical cysts (HP:0000803)2.27963879
78Abnormality of pyrimidine metabolism (HP:0004353)2.27701662
79Multiple enchondromatosis (HP:0005701)2.27234774
80Hydroxyprolinuria (HP:0003080)2.25920966
81Abnormality of proline metabolism (HP:0010907)2.25920966
82Hyperglycemia (HP:0003074)2.25022940
83Exercise-induced muscle cramps (HP:0003710)2.24926988
84Hemorrhage of the eye (HP:0011885)2.23764207
85Alkalosis (HP:0001948)2.23487162
86Pancreatitis (HP:0001733)2.20878969
87Aplasia of the musculature (HP:0100854)2.18794148
88Hepatic necrosis (HP:0002605)2.18068737
89Sudden death (HP:0001699)2.15958668
90Symptomatic seizures (HP:0011145)2.15670212
91Abnormal gallbladder morphology (HP:0012437)2.13551856
92Large for gestational age (HP:0001520)2.12900311
93Mesangial abnormality (HP:0001966)2.12742829
94Nausea (HP:0002018)2.11733876
95Pancreatic islet-cell hyperplasia (HP:0004510)2.11273654
96Cholelithiasis (HP:0001081)2.10392574
97Lymphangioma (HP:0100764)2.10038590
98Neonatal onset (HP:0003623)2.09997201
99Hepatocellular carcinoma (HP:0001402)2.08263461
100Myocardial infarction (HP:0001658)2.08197693
101Malnutrition (HP:0004395)2.06515255
102Atrioventricular block (HP:0001678)2.04382600
103Irritability (HP:0000737)2.02768066
104Hepatoblastoma (HP:0002884)2.01878505
105Type II lissencephaly (HP:0007260)2.01771316
106Steatorrhea (HP:0002570)1.98670101
107Acute encephalopathy (HP:0006846)1.96921941
108Cardiovascular calcification (HP:0011915)1.96748398
109Methylmalonic aciduria (HP:0012120)1.96197617
110Systemic lupus erythematosus (HP:0002725)1.95729654
111Hyperactive renin-angiotensin system (HP:0000841)1.94816106
112Hypokalemic alkalosis (HP:0001949)1.93249051
113Bronchomalacia (HP:0002780)1.93233725
114Tachypnea (HP:0002789)1.92798107
115Increased muscle lipid content (HP:0009058)1.92722693
116Abnormality of glycolysis (HP:0004366)1.92344530
117Increased serum pyruvate (HP:0003542)1.92344530
118Heart block (HP:0012722)1.90319872
119Right ventricular cardiomyopathy (HP:0011663)1.89119293
120Increased circulating renin level (HP:0000848)1.88953662
121Glomerulonephritis (HP:0000099)1.87936442
122Type I transferrin isoform profile (HP:0003642)1.87519714
123Spontaneous abortion (HP:0005268)1.85852798
124Retinal dysplasia (HP:0007973)1.84737599
125Bifid scrotum (HP:0000048)1.84379870
126Hyperventilation (HP:0002883)1.82166646
127Neonatal hypoglycemia (HP:0001998)1.82027483
128Brushfield spots (HP:0001088)1.81291610
129Aplasia/Hypoplasia involving the musculature (HP:0001460)1.78677009
130Spastic paraparesis (HP:0002313)1.78634351
131Abnormal atrioventricular conduction (HP:0005150)1.73588219
132Abnormality of the calf musculature (HP:0001430)1.67500566
133Methylmalonic acidemia (HP:0002912)1.67356243
134Hepatocellular necrosis (HP:0001404)1.66763958
135Epiphyseal stippling (HP:0010655)1.66685590
136Lactic acidosis (HP:0003128)1.66645099
137Progressive muscle weakness (HP:0003323)1.61320737
138Microretrognathia (HP:0000308)1.59737598
139Limb hypertonia (HP:0002509)1.59173256
140Gowers sign (HP:0003391)1.57740305
141Oligomenorrhea (HP:0000876)1.57517290
142Increased serum lactate (HP:0002151)1.55464610
143Nephritis (HP:0000123)1.54726098
144Abnormality of vitamin metabolism (HP:0100508)1.54364703

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK6.06214674
2ERN14.11619352
3INSRR3.34692194
4SIK13.28374090
5VRK23.20126376
6SMG12.75456415
7EEF2K2.59528512
8WNK42.48578657
9TRIB32.44107607
10EPHA22.28124167
11TNK22.26397807
12MAPKAPK32.23652601
13FGFR42.15212866
14PDK32.11658933
15PDK42.11658933
16TSSK62.05143095
17PHKG22.02573810
18PHKG12.02573810
19OBSCN1.99100973
20LMTK21.96608898
21PINK11.94587539
22GRK11.89324089
23WNK31.80376125
24TTN1.78886930
25MUSK1.72329964
26GRK51.68267382
27PKN21.65170119
28CDK121.62415773
29NUAK11.54339699
30GRK61.49916824
31GRK71.49078033
32MAP3K71.45986746
33MAP2K41.43901095
34CAMK1D1.38175654
35TGFBR21.35475295
36PRKAA21.34071559
37OXSR11.33043420
38PDK21.29718940
39WNK11.28934823
40AKT31.28404295
41PIM21.27608215
42STK161.27347715
43NME11.26587197
44TIE11.22652206
45MAPK71.22165784
46MAP2K21.18458059
47MYLK1.17812621
48TAOK31.17472797
49MAPK121.17115239
50LIMK11.14621774
51PIK3CG1.12489821
52FLT31.10353849
53PRKAA11.04165203
54LATS11.04102068
55STK38L1.02690158
56CAMK1G0.99501291
57IRAK30.99112482
58CAMK40.98549978
59MAPK130.97384681
60MAPK110.95804514
61ADRBK20.93619959
62STK390.93105261
63MST1R0.92838314
64EPHB10.90114095
65CSF1R0.89890534
66MAPK150.87017892
67TESK20.86785296
68FRK0.86536582
69RIPK10.86245258
70PAK30.85224478
71PRKCI0.84771189
72MAP4K20.81323448
73PTK60.79526767
74ICK0.77461556
75CAMK10.77139225
76FGFR30.75219599
77ERBB40.73885203
78PRKACG0.73377595
79VRK10.72962313
80PIK3CA0.72841767
81CDK190.71802100
82PRKD10.71564303
83DAPK10.68781711
84PKN10.68741980
85RPS6KB20.67689867
86FER0.67495357
87ATR0.65782846
88SGK4940.65013497
89SGK2230.65013497
90STK380.64402931
91CAMK2G0.63303187
92JAK20.62993166
93CDK70.62265571
94NEK10.62128573
95PNCK0.61732525
96ABL20.60290260
97MAP2K60.59681169
98CSNK1G30.59003783
99SGK30.58569061
100CSNK1A1L0.58047574
101CAMK2D0.57846057
102HIPK20.56656019
103MAPKAPK50.55595802
104GSK3A0.55588429
105MAP3K100.54308585
106MAP2K30.54281878
107SGK20.52829654
108RPS6KA20.52692082
109EPHA30.50397646
110CSNK1A10.50163899
111PDPK10.49565696
112NEK90.49398602
113MAP3K30.48978894
114RPS6KA60.47885664
115DMPK0.47781000
116PDGFRA0.47556941
117PAK20.46428474
118PRKACA0.46024949
119FGFR20.45986875
120PRKCZ0.45979921
121JAK10.45954218
122CSNK1G20.45331430
123AKT20.44512044
124MET0.44026264
125CSNK1D0.43396809
126ADRBK10.43169681
127TLK10.43069947
128PRKDC0.42287756
129PRKD30.42180352
130MAPK40.42179982
131ZAK0.41124718
132CSK0.40510732
133TYRO30.39620798
134IGF1R0.39455911
135CDC42BPA0.39429941
136CSNK1G10.39219319
137NTRK10.38038116
138PRKD20.36765683
139PDK10.36469720
140EIF2AK10.35446857
141DYRK1B0.35330575
142IRAK10.35308294
143MARK20.35139188
144TYK20.34638905
145RPS6KC10.34470367
146RPS6KL10.34470367
147MTOR0.34453637
148IRAK20.33799446
149ERBB20.33763524
150CAMK2B0.33301538
151PRKCH0.32897412
152MAPK80.32030132
153DAPK30.30810905
154TESK10.30140718
155NTRK30.29377839

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001203.30088267
2* Valine, leucine and isoleucine degradation_Homo sapiens_hsa002803.25188096
3Fatty acid degradation_Homo sapiens_hsa000713.08099812
4Propanoate metabolism_Homo sapiens_hsa006403.03708636
5Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.94431359
6Nitrogen metabolism_Homo sapiens_hsa009102.88983110
7Tryptophan metabolism_Homo sapiens_hsa003802.73596899
8Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.72770619
9Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.67580911
10Butanoate metabolism_Homo sapiens_hsa006502.60633417
112-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.55649101
12Arginine biosynthesis_Homo sapiens_hsa002202.41323106
13Fatty acid metabolism_Homo sapiens_hsa012122.39594568
14Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.33098090
15Pentose and glucuronate interconversions_Homo sapiens_hsa000402.22162211
16Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.15266596
17Peroxisome_Homo sapiens_hsa041462.14855536
18PPAR signaling pathway_Homo sapiens_hsa033202.14396920
19Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.14025769
20beta-Alanine metabolism_Homo sapiens_hsa004101.95197454
21Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.92908848
22Complement and coagulation cascades_Homo sapiens_hsa046101.83529859
23Pyruvate metabolism_Homo sapiens_hsa006201.78653716
24Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.71251103
25Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.69739239
26Carbon metabolism_Homo sapiens_hsa012001.67296287
27Fatty acid elongation_Homo sapiens_hsa000621.59541126
28Chemical carcinogenesis_Homo sapiens_hsa052041.56644406
29Steroid hormone biosynthesis_Homo sapiens_hsa001401.47663826
30Histidine metabolism_Homo sapiens_hsa003401.47600248
31Caffeine metabolism_Homo sapiens_hsa002321.47372242
32Phenylalanine metabolism_Homo sapiens_hsa003601.45106473
33Starch and sucrose metabolism_Homo sapiens_hsa005001.41176762
34Sulfur metabolism_Homo sapiens_hsa009201.39564343
35Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.39554038
36Bile secretion_Homo sapiens_hsa049761.32097688
37Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.30263080
38Retinol metabolism_Homo sapiens_hsa008301.28471928
39Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.25340031
40Tyrosine metabolism_Homo sapiens_hsa003501.24464869
41Biosynthesis of amino acids_Homo sapiens_hsa012301.19880312
42Selenocompound metabolism_Homo sapiens_hsa004501.16068592
43Maturity onset diabetes of the young_Homo sapiens_hsa049501.15866422
44Vitamin B6 metabolism_Homo sapiens_hsa007501.15014520
45Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.13040485
46Drug metabolism - other enzymes_Homo sapiens_hsa009831.11288929
47ABC transporters_Homo sapiens_hsa020101.07291249
48Arginine and proline metabolism_Homo sapiens_hsa003301.06992442
49Glycerolipid metabolism_Homo sapiens_hsa005611.05542226
50Lysine degradation_Homo sapiens_hsa003101.03864282
51Fat digestion and absorption_Homo sapiens_hsa049751.02062129
52Cysteine and methionine metabolism_Homo sapiens_hsa002700.99232431
53Fatty acid biosynthesis_Homo sapiens_hsa000610.98924635
54Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.97862256
55Staphylococcus aureus infection_Homo sapiens_hsa051500.96923084
56Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.95298513
57Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.93649439
58Cyanoamino acid metabolism_Homo sapiens_hsa004600.87628701
59Folate biosynthesis_Homo sapiens_hsa007900.87195273
60Vitamin digestion and absorption_Homo sapiens_hsa049770.83410866
61Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.75135181
62Fructose and mannose metabolism_Homo sapiens_hsa000510.73570430
63Sulfur relay system_Homo sapiens_hsa041220.70299874
64Glutathione metabolism_Homo sapiens_hsa004800.65486144
65Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.59756896
66Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.59347875
67Galactose metabolism_Homo sapiens_hsa000520.58608676
68Steroid biosynthesis_Homo sapiens_hsa001000.58196099
69* Metabolic pathways_Homo sapiens_hsa011000.54779025
70Adipocytokine signaling pathway_Homo sapiens_hsa049200.54758677
71Insulin resistance_Homo sapiens_hsa049310.53220811
72alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.52534092
73Base excision repair_Homo sapiens_hsa034100.50854019
74Pentose phosphate pathway_Homo sapiens_hsa000300.50147246
75Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.45917482
76Linoleic acid metabolism_Homo sapiens_hsa005910.42036155
77Oxidative phosphorylation_Homo sapiens_hsa001900.39062209
78Glucagon signaling pathway_Homo sapiens_hsa049220.33490708
79AMPK signaling pathway_Homo sapiens_hsa041520.33232330
80Cardiac muscle contraction_Homo sapiens_hsa042600.30959165
81Arachidonic acid metabolism_Homo sapiens_hsa005900.26443466
82Parkinsons disease_Homo sapiens_hsa050120.26224202
83Non-homologous end-joining_Homo sapiens_hsa034500.25491089
84Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.25394272
85RNA polymerase_Homo sapiens_hsa030200.23486430
86Glycerophospholipid metabolism_Homo sapiens_hsa005640.22685244
87Circadian rhythm_Homo sapiens_hsa047100.22536233
88Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.22371297
89Ovarian steroidogenesis_Homo sapiens_hsa049130.19520888
90Fanconi anemia pathway_Homo sapiens_hsa034600.18451443
91Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.16752231
92Pyrimidine metabolism_Homo sapiens_hsa002400.15432274
93Alzheimers disease_Homo sapiens_hsa050100.15029514
94One carbon pool by folate_Homo sapiens_hsa006700.14883455
95Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.12312357
96Insulin signaling pathway_Homo sapiens_hsa049100.11465729
97N-Glycan biosynthesis_Homo sapiens_hsa005100.10553183
98Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.08740050
99Dilated cardiomyopathy_Homo sapiens_hsa054140.08293342
100Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.06525224
101Other glycan degradation_Homo sapiens_hsa005110.06338358
102Glycosaminoglycan degradation_Homo sapiens_hsa005310.06169651
103Protein digestion and absorption_Homo sapiens_hsa049740.05644101
104Purine metabolism_Homo sapiens_hsa002300.05426160
105Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.05376304
106Prion diseases_Homo sapiens_hsa050200.03484726
107Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.03072722
108Thyroid hormone synthesis_Homo sapiens_hsa049180.02751236
109Renin-angiotensin system_Homo sapiens_hsa046140.02432092
110Huntingtons disease_Homo sapiens_hsa05016-0.0627530
111Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412-0.0582976
112Longevity regulating pathway - mammal_Homo sapiens_hsa04211-0.0469351
113Regulation of autophagy_Homo sapiens_hsa04140-0.0436804
114Carbohydrate digestion and absorption_Homo sapiens_hsa04973-0.0434622
115Terpenoid backbone biosynthesis_Homo sapiens_hsa00900-0.0409706

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