IVNS1ABP

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cardiac myofibril assembly (GO:0055003)5.16226019
2positive regulation of gamma-delta T cell activation (GO:0046645)5.07273243
3tricarboxylic acid cycle (GO:0006099)4.91736998
4sarcomere organization (GO:0045214)4.81721789
5cellular extravasation (GO:0045123)4.79586749
6negative regulation of potassium ion transmembrane transporter activity (GO:1901017)4.65117408
7pyrimidine ribonucleoside catabolic process (GO:0046133)4.30541023
8regulation of sarcomere organization (GO:0060297)4.30382324
9cytidine metabolic process (GO:0046087)4.22990764
10cytidine catabolic process (GO:0006216)4.22990764
11cytidine deamination (GO:0009972)4.22990764
12negative regulation of potassium ion transmembrane transport (GO:1901380)4.22833070
13granulocyte activation (GO:0036230)4.21365240
14regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)4.10948153
15response to peptidoglycan (GO:0032494)4.08173723
16negative regulation of cell killing (GO:0031342)4.07170495
17negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.07170495
18neutrophil activation (GO:0042119)4.04375617
19cardiac muscle contraction (GO:0060048)4.03175224
20myofibril assembly (GO:0030239)4.02395185
21positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.95048044
22detection of other organism (GO:0098543)3.91667168
23regulation of gamma-delta T cell activation (GO:0046643)3.90944155
24antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.90723077
25mitotic sister chromatid cohesion (GO:0007064)3.84981286
26regulation of B cell receptor signaling pathway (GO:0050855)3.78874225
27production of molecular mediator involved in inflammatory response (GO:0002532)3.78696307
28respiratory burst (GO:0045730)3.77872117
29cardiac muscle hypertrophy (GO:0003300)3.77786816
30cardiac muscle cell development (GO:0055013)3.76459815
31response to interleukin-15 (GO:0070672)3.74223358
32regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.73826410
33negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.70457033
34DNA unwinding involved in DNA replication (GO:0006268)3.69521453
35cellular response to interleukin-15 (GO:0071350)3.65895484
36regulation of gamma-delta T cell differentiation (GO:0045586)3.65260037
37cardiac cell development (GO:0055006)3.62664977
38negative regulation of interleukin-12 production (GO:0032695)3.61278413
39neutrophil activation involved in immune response (GO:0002283)3.61033419
40leukocyte migration involved in inflammatory response (GO:0002523)3.59424134
41striated muscle hypertrophy (GO:0014897)3.51123323
42detection of molecule of bacterial origin (GO:0032490)3.49447111
43regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO3.44694896
44carnitine shuttle (GO:0006853)3.44371864
45neutrophil mediated immunity (GO:0002446)3.41098351
46regulation of lymphocyte chemotaxis (GO:1901623)3.40037605
47regulation of acyl-CoA biosynthetic process (GO:0050812)3.39576264
48ventricular cardiac muscle cell action potential (GO:0086005)3.38033826
49negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)3.37806007
50mitotic chromosome condensation (GO:0007076)3.37156382
51detection of bacterium (GO:0016045)3.34113601
52negative regulation of B cell proliferation (GO:0030889)3.33823940
53positive regulation of tolerance induction (GO:0002645)3.33144844
54bundle of His cell to Purkinje myocyte communication (GO:0086069)3.32583932
55response to muramyl dipeptide (GO:0032495)3.31832431
56tricarboxylic acid metabolic process (GO:0072350)3.31783222
57lysine metabolic process (GO:0006553)3.31113132
58lysine catabolic process (GO:0006554)3.31113132
59relaxation of cardiac muscle (GO:0055119)3.31063682
60dosage compensation (GO:0007549)3.28669183
61positive regulation of B cell differentiation (GO:0045579)3.27078195
622-oxoglutarate metabolic process (GO:0006103)3.26926082
63regulation of interleukin-12 biosynthetic process (GO:0045075)3.25122225
64regulation of tolerance induction (GO:0002643)3.24541885
65negative regulation of RNA splicing (GO:0033119)3.24285168
66positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)3.23825143
67Notch signaling involved in heart development (GO:0061314)3.23296102
68dendritic cell chemotaxis (GO:0002407)3.22939319
69leukocyte aggregation (GO:0070486)3.22311618
70actomyosin structure organization (GO:0031032)3.21542805
71detection of external biotic stimulus (GO:0098581)3.21532476
72interferon-gamma production (GO:0032609)3.20016196
73regulation of regulatory T cell differentiation (GO:0045589)3.19746015
74regulation of B cell differentiation (GO:0045577)3.15113139
75regulation of coenzyme metabolic process (GO:0051196)3.14666444
76regulation of cofactor metabolic process (GO:0051193)3.14666444
77lipopolysaccharide-mediated signaling pathway (GO:0031663)3.13105653
78peptidyl-lysine dimethylation (GO:0018027)3.10423583
79regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)3.09584477
80regulation of T cell tolerance induction (GO:0002664)3.07791445
81germ cell migration (GO:0008354)3.06982995
82positive regulation by symbiont of host defense response (GO:0052509)3.06128184
83modulation by symbiont of host defense response (GO:0052031)3.06128184
84modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.06128184
85modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.06128184
86positive regulation by organism of defense response of other organism involved in symbiotic interact3.06128184
87modulation by symbiont of host immune response (GO:0052553)3.06128184
88regulation of nitric-oxide synthase biosynthetic process (GO:0051769)3.05007676
89negative regulation of mRNA processing (GO:0050686)3.04654178
90positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.03565579
91NADH metabolic process (GO:0006734)3.03382536
92neutrophil migration (GO:1990266)3.02522184
93dendritic cell migration (GO:0036336)3.02309833
94eosinophil chemotaxis (GO:0048245)3.02027388
95heart trabecula formation (GO:0060347)3.01183102
96neutrophil chemotaxis (GO:0030593)3.00897746
97myeloid leukocyte mediated immunity (GO:0002444)2.96943788
98membrane repolarization during cardiac muscle cell action potential (GO:0086013)2.95363750
99detection of biotic stimulus (GO:0009595)2.95355389
100regulation of actin filament-based movement (GO:1903115)2.94003847
101nuclear pore complex assembly (GO:0051292)2.93792177
102positive regulation of DNA-templated transcription, initiation (GO:2000144)2.92790480
103cardiac muscle hypertrophy in response to stress (GO:0014898)2.92648625
104muscle hypertrophy in response to stress (GO:0003299)2.92648625
105cardiac muscle adaptation (GO:0014887)2.92648625
106monoubiquitinated protein deubiquitination (GO:0035520)2.91671916
107valine metabolic process (GO:0006573)2.90444902
108muscle hypertrophy (GO:0014896)2.89039483
109regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)2.88625986
110carnitine transport (GO:0015879)2.88130733
111amino-acid betaine transport (GO:0015838)2.88130733
112fatty acid transmembrane transport (GO:1902001)2.87732526
113regulation of sulfur metabolic process (GO:0042762)2.87420254
114negative regulation of glycoprotein biosynthetic process (GO:0010561)2.86688304
115granulocyte chemotaxis (GO:0071621)2.85566453
116response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.84881108
117response to host immune response (GO:0052572)2.84881108
118carnitine transmembrane transport (GO:1902603)2.83986793
119leukocyte degranulation (GO:0043299)2.83930715
120nuclear pore organization (GO:0006999)2.83437269
121granulocyte migration (GO:0097530)2.83349055
122cytokine secretion (GO:0050663)2.82484687
123negative regulation of B cell activation (GO:0050869)2.81958784
124DNA topological change (GO:0006265)2.81694656
125Arp2/3 complex-mediated actin nucleation (GO:0034314)2.81080777
126eosinophil migration (GO:0072677)2.79948429
127translesion synthesis (GO:0019985)2.79152256
128positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.77922328
129regulation of relaxation of muscle (GO:1901077)2.77861373
130pore complex assembly (GO:0046931)2.76998224
131cardiac conduction (GO:0061337)2.75615656
132polyol transport (GO:0015791)2.75528628
133mRNA stabilization (GO:0048255)2.74240311
134RNA stabilization (GO:0043489)2.74240311
135actin-myosin filament sliding (GO:0033275)2.74022910
136muscle filament sliding (GO:0030049)2.74022910
137T cell migration (GO:0072678)2.72416814
1383-UTR-mediated mRNA stabilization (GO:0070935)2.72354014
139regulation of skeletal muscle contraction (GO:0014819)2.70737072
140macrophage activation involved in immune response (GO:0002281)2.69667533
141glucocorticoid receptor signaling pathway (GO:0042921)2.69593421
142striated muscle contraction (GO:0006941)2.69209639
143negative regulation of mRNA metabolic process (GO:1903312)2.69195229
144cell communication involved in cardiac conduction (GO:0086065)2.69182898
145DNA duplex unwinding (GO:0032508)2.69142900
146cardiac muscle tissue morphogenesis (GO:0055008)2.67497139
147negative regulation of lymphocyte mediated immunity (GO:0002707)2.66363956
148activated T cell proliferation (GO:0050798)2.66253732
149DNA geometric change (GO:0032392)2.65749861
150regulation of sister chromatid cohesion (GO:0007063)2.65258541
151regulation of mononuclear cell migration (GO:0071675)2.64571810
152positive regulation of toll-like receptor signaling pathway (GO:0034123)2.64308888
153interkinetic nuclear migration (GO:0022027)2.63948422
154antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.63510115
155myeloid cell activation involved in immune response (GO:0002275)2.62713369
156monocyte chemotaxis (GO:0002548)2.62206896
157fibroblast migration (GO:0010761)2.61551803
158regulation of alpha-beta T cell proliferation (GO:0046640)2.61480639
159membrane repolarization during action potential (GO:0086011)2.60045538
160regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)2.59220295
161negative T cell selection (GO:0043383)2.58292808
162regulation of natural killer cell mediated cytotoxicity (GO:0042269)2.57654967
163regulation of natural killer cell mediated immunity (GO:0002715)2.57654967
164positive regulation of interleukin-8 secretion (GO:2000484)2.56411424
165positive regulation of interleukin-1 beta secretion (GO:0050718)2.54284380
166regulation of RNA export from nucleus (GO:0046831)2.53506318
167positive regulation of lymphocyte migration (GO:2000403)2.53504571
168myeloid leukocyte activation (GO:0002274)2.53283474
169cellular response to osmotic stress (GO:0071470)2.52115102
170regulation of interferon-beta biosynthetic process (GO:0045357)2.52100984
171cellular response to ethanol (GO:0071361)2.50665677
172COPI coating of Golgi vesicle (GO:0048205)2.50514091
173Golgi transport vesicle coating (GO:0048200)2.50514091
174epithelial cell-cell adhesion (GO:0090136)2.50023714
175cellular defense response (GO:0006968)2.49935005
176definitive hemopoiesis (GO:0060216)2.49923850
177positive regulation of transcription initiation from RNA polymerase II promoter (GO:0060261)2.49858380
178germinal center formation (GO:0002467)2.48829895
179regulation of activation of Janus kinase activity (GO:0010533)2.48601119
180regulation of membrane repolarization (GO:0060306)2.48194953
181regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.46582902
182negative regulation of interleukin-1 beta production (GO:0032691)2.46309144
183positive regulation of monocyte chemotaxis (GO:0090026)2.46289949
184regulation of mRNA stability (GO:0043488)2.46203440
185regulation of T cell chemotaxis (GO:0010819)2.45874782
186positive regulation of T cell chemotaxis (GO:0010820)2.45874782
187cardiac muscle cell action potential involved in contraction (GO:0086002)2.45758900
188regulation of the force of heart contraction (GO:0002026)2.45400969
189cytoplasmic mRNA processing body assembly (GO:0033962)2.45205688
190negative regulation of histone methylation (GO:0031061)2.44522677
191ventricular cardiac muscle tissue morphogenesis (GO:0055010)2.43124659
192negative regulation of granulocyte differentiation (GO:0030853)2.42761070
193ventricular cardiac muscle cell development (GO:0055015)2.42497574
194cardiac muscle cell action potential (GO:0086001)2.42234255
195muscle tissue morphogenesis (GO:0060415)2.41777705
196fatty acid beta-oxidation (GO:0006635)2.38906737
197quaternary ammonium group transport (GO:0015697)2.38668016

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human9.05524323
2BP1_19119308_ChIP-ChIP_Hs578T_Human8.06652759
3FOXM1_23109430_ChIP-Seq_U2OS_Human4.16794571
4EGR1_19374776_ChIP-ChIP_THP-1_Human3.95115864
5NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.56545282
6IRF8_21731497_ChIP-ChIP_J774_Mouse3.36125699
7* MYC_22102868_ChIP-Seq_BL_Human3.07809756
8SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.93196668
9IRF8_27001747_Chip-Seq_BMDM_Mouse2.91816971
10IRF8_22096565_ChIP-ChIP_GC-B_Human2.82583460
11E2F4_17652178_ChIP-ChIP_JURKAT_Human2.70700811
12PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.61582566
13SMAD_19615063_ChIP-ChIP_OVARY_Human2.51092992
14ZNF263_19887448_ChIP-Seq_K562_Human2.50358965
15Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.43978515
16CIITA_25753668_ChIP-Seq_RAJI_Human2.37137060
17STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.35139154
18STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.31141750
19CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.28906962
20* CLOCK_20551151_ChIP-Seq_293T_Human2.25468619
21* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.24474119
22E2F1_21310950_ChIP-Seq_MCF-7_Human2.11939463
23* IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.10619488
24TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.04543561
25* GATA1_22025678_ChIP-Seq_K562_Human2.04154833
26* TCF7_22412390_ChIP-Seq_EML_Mouse2.02789937
27FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.02125037
28SCL_19346495_ChIP-Seq_HPC-7_Human1.97566802
29AR_21909140_ChIP-Seq_LNCAP_Human1.92586232
30ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.91821276
31* SPI1_23547873_ChIP-Seq_NB4_Human1.88022193
32EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.86583595
33VDR_21846776_ChIP-Seq_THP-1_Human1.86447300
34VDR_24787735_ChIP-Seq_THP-1_Human1.86060593
35PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.84294321
36STAT4_19710469_ChIP-ChIP_TH1__Mouse1.83318455
37IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.80522569
38TBX20_22328084_ChIP-Seq_HEART_Mouse1.75044641
39TBX20_22080862_ChIP-Seq_HEART_Mouse1.75044641
40SALL1_21062744_ChIP-ChIP_HESCs_Human1.74688029
41HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.72086975
42RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.70572052
43CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.70334953
44NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.70150004
45WT1_19549856_ChIP-ChIP_CCG9911_Human1.69459876
46KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.63680474
47KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.61179656
48KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.61179656
49KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.61179656
50* GATA4_21415370_ChIP-Seq_HL-1_Mouse1.57784171
51* PU_27001747_Chip-Seq_BMDM_Mouse1.54756777
52RBPJ_22232070_ChIP-Seq_NCS_Mouse1.53910486
53SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.50454771
54PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.49524125
55* MAF_26560356_Chip-Seq_TH1_Human1.47098888
56FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.45494206
57RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.43382050
58NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.42941775
59* KDM2B_26808549_Chip-Seq_DND41_Human1.41694994
60* MYC_18555785_ChIP-Seq_MESCs_Mouse1.41356785
61DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.40885417
62YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.40884521
63ESR1_20079471_ChIP-ChIP_T-47D_Human1.40427709
64NELFA_20434984_ChIP-Seq_ESCs_Mouse1.40232430
65NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.39245013
66ESR1_21235772_ChIP-Seq_MCF-7_Human1.38584355
67* UTX_26944678_Chip-Seq_JUKART_Human1.37112607
68KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.36474159
69* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.34774973
70* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.34330436
71FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.34248667
72MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.31632053
73* SALL4_18804426_ChIP-ChIP_XEN_Mouse1.29708985
74ZFX_18555785_ChIP-Seq_MESCs_Mouse1.29167696
75PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.28387242
76* GATA3_26560356_Chip-Seq_TH2_Human1.28042252
77* CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.27252757
78* CHD1_26751641_Chip-Seq_LNCaP_Human1.24998030
79* MYB_26560356_Chip-Seq_TH2_Human1.24855164
80EP300_21415370_ChIP-Seq_HL-1_Mouse1.23822511
81VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.18656410
82* BRD4_27068464_Chip-Seq_AML-cells_Mouse1.18095979
83* MYB_26560356_Chip-Seq_TH1_Human1.17113001
84FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.16505879
85TP63_17297297_ChIP-ChIP_HaCaT_Human1.15260866
86TAF15_26573619_Chip-Seq_HEK293_Human1.15092361
87* MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.13592322
88* TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.13577792
89POU3F2_20337985_ChIP-ChIP_501MEL_Human1.13438812
90FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.13156552
91TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.11863729
92* FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.11720229
93* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.11264161
94RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.10628746
95* SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.10227176
96VDR_24763502_ChIP-Seq_THP-1_Human1.09282305
97PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.09267703
98* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.08530911
99* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.06942351
100TCF4_18268006_ChIP-ChIP_LS174T_Human1.06547820
101MYB_21317192_ChIP-Seq_ERMYB_Mouse1.05959299
102* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.05502433
103GATA2_21666600_ChIP-Seq_HMVEC_Human1.04218314
104NCOR1_26117541_ChIP-Seq_K562_Human1.03074987
105* GATA6_25053715_ChIP-Seq_YYC3_Human1.02376907
106KDM5A_27292631_Chip-Seq_BREAST_Human1.01243024
107SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.00928111
108* KLF4_18555785_ChIP-Seq_MESCs_Mouse1.00595041
109MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.00590485
110ATF3_27146783_Chip-Seq_COLON_Human0.99961411
111RUNX_20019798_ChIP-Seq_JUKART_Human0.99925866
112STAT6_21828071_ChIP-Seq_BEAS2B_Human0.99713422
113CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.99546737
114* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.98292210
115TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.98223032
116* EZH2_27294783_Chip-Seq_NPCs_Mouse0.97960324
117* ELK3_25401928_ChIP-Seq_HUVEC_Human0.97871867
118E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.97297087
119* MYC_19079543_ChIP-ChIP_MESCs_Mouse0.96360568
120DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.96330787
121* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.95627267
122NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.95545173
123RUNX1_27514584_Chip-Seq_MCF-7_Human0.95345000
124* GATA1_22383799_ChIP-Seq_G1ME_Mouse0.94487546
125* GATA3_27048872_Chip-Seq_THYMUS_Human0.94375956
126* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.94110334
127* CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.94029263
128RUNX1_22412390_ChIP-Seq_EML_Mouse0.93720583
129* HOXB4_20404135_ChIP-ChIP_EML_Mouse0.93427218
130* MYC_19030024_ChIP-ChIP_MESCs_Mouse0.93329086
131CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.92765421
132* ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.92622932
133SPI1_23127762_ChIP-Seq_K562_Human0.91753644
134FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.91371759
135STAT3_20064451_ChIP-Seq_CD4+T_Mouse0.91104333
136* TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.90996792
137PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.90902072
138CDX2_19796622_ChIP-Seq_MESCs_Mouse0.90444793
139FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.90157783
140* GATA2_22383799_ChIP-Seq_G1ME_Mouse0.89559377
141* SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.89092145
142FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.88480718
143* P300_27058665_Chip-Seq_ZR-75-30cells_Human0.88228699
144* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.88214408
145* SOX2_27498859_Chip-Seq_STOMACH_Mouse0.86199073
146* SUZ12_27294783_Chip-Seq_NPCs_Mouse0.85357538
147* TP63_23658742_ChIP-Seq_EP156T_Human0.84706812
148FOXO3_23340844_ChIP-Seq_DLD1_Human0.82659269
149* SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.82629331
150* SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.82629331
151NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.81920179
152* NFE2_27457419_Chip-Seq_LIVER_Mouse0.79240157
153CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.77781279
154LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.76801109
155* GATA2_19941826_ChIP-Seq_K562_Human0.75112209
156* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.74699233
157* OCT4_21477851_ChIP-Seq_ESCs_Mouse0.74561934
158TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.74346031
159GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.73809359
160SALL4_22934838_ChIP-ChIP_CD34+_Human0.73759999
161* GATA1_19941827_ChIP-Seq_MEL86_Mouse0.73513871
162SMAD3_21741376_ChIP-Seq_HESCs_Human0.72097727
163SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.70348126
164* CMYC_18555785_Chip-Seq_ESCs_Mouse0.69064666
165NOTCH1_21737748_ChIP-Seq_TLL_Human0.69049927

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004084_abnormal_cardiac_muscle4.31411573
2MP0003724_increased_susceptibility_to4.04983312
3MP0005671_abnormal_response_to3.45709264
4MP0004215_abnormal_myocardial_fiber3.20658062
5MP0003303_peritoneal_inflammation3.09521677
6MP0003436_decreased_susceptibility_to2.79770274
7MP0000751_myopathy2.77154603
8MP0003646_muscle_fatigue2.74700136
9MP0002837_dystrophic_cardiac_calcinosis2.63301779
10MP0002396_abnormal_hematopoietic_system2.53715510
11MP0005330_cardiomyopathy2.48144501
12MP0002419_abnormal_innate_immunity2.46501588
13MP0009785_altered_susceptibility_to2.38127338
14MP0003300_gastrointestinal_ulcer2.37244252
15MP0004036_abnormal_muscle_relaxation2.34332374
16MP0001835_abnormal_antigen_presentation2.33674507
17MP0010630_abnormal_cardiac_muscle2.33126643
18MP0005025_abnormal_response_to2.28930045
19MP0001800_abnormal_humoral_immune2.26651428
20MP0006082_CNS_inflammation2.24871408
21MP0005000_abnormal_immune_tolerance2.24820437
22MP0002723_abnormal_immune_serum2.19047558
23MP0004130_abnormal_muscle_cell2.17208987
24MP0002420_abnormal_adaptive_immunity2.14476885
25MP0003828_pulmonary_edema2.13729215
26MP0001819_abnormal_immune_cell2.12841886
27MP0002148_abnormal_hypersensitivity_rea2.12323786
28MP0004087_abnormal_muscle_fiber2.10508218
29MP0003567_abnormal_fetal_cardiomyocyte2.09350246
30MP0008775_abnormal_heart_ventricle2.08030422
31MP0003890_abnormal_embryonic-extraembry2.06305480
32MP0002452_abnormal_antigen_presenting2.04923174
33MP0000465_gastrointestinal_hemorrhage1.99069004
34MP0004947_skin_inflammation1.97802051
35MP0010094_abnormal_chromosome_stability1.96126815
36MP0008260_abnormal_autophagy1.95449939
37MP0004484_altered_response_of1.93659293
38MP0004381_abnormal_hair_follicle1.87461747
39MP0008004_abnormal_stomach_pH1.81806240
40MP0001790_abnormal_immune_system1.79091252
41MP0005387_immune_system_phenotype1.79091252
42MP0001544_abnormal_cardiovascular_syste1.78726916
43MP0005385_cardiovascular_system_phenoty1.78726916
44MP0006054_spinal_hemorrhage1.78508564
45* MP0002972_abnormal_cardiac_muscle1.77335869
46MP0010234_abnormal_vibrissa_follicle1.77181750
47MP0004808_abnormal_hematopoietic_stem1.72241847
48MP0010352_gastrointestinal_tract_polyps1.69396631
49MP0002405_respiratory_system_inflammati1.68818060
50MP0002398_abnormal_bone_marrow1.66246356
51MP0005666_abnormal_adipose_tissue1.65970844
52MP0000749_muscle_degeneration1.63651174
53MP0000716_abnormal_immune_system1.61590175
54MP0010155_abnormal_intestine_physiology1.60804468
55MP0003448_altered_tumor_morphology1.58908640
56MP0003693_abnormal_embryo_hatching1.58185789
57MP0005464_abnormal_platelet_physiology1.55157727
58MP0002254_reproductive_system_inflammat1.53264753
59MP0000750_abnormal_muscle_regeneration1.51330446
60MP0008961_abnormal_basal_metabolism1.48306013
61MP0003984_embryonic_growth_retardation1.46328020
62MP0006138_congestive_heart_failure1.46210125
63MP0002088_abnormal_embryonic_growth/wei1.44466744
64MP0003656_abnormal_erythrocyte_physiolo1.42518561
65MP0001845_abnormal_inflammatory_respons1.41462750
66MP0002722_abnormal_immune_system1.41108977
67MP0003137_abnormal_impulse_conducting1.40511798
68MP0002106_abnormal_muscle_physiology1.39987667
69MP0002166_altered_tumor_susceptibility1.38950435
70* MP0005620_abnormal_muscle_contractility1.38915402
71MP0000689_abnormal_spleen_morphology1.37237928
72MP0002269_muscular_atrophy1.36848224
73MP0001533_abnormal_skeleton_physiology1.36210764
74* MP0003221_abnormal_cardiomyocyte_apopto1.35141812
75MP0001851_eye_inflammation1.34311040
76MP0008007_abnormal_cellular_replicative1.32213529
77MP0003077_abnormal_cell_cycle1.31765587
78MP0000266_abnormal_heart_morphology1.31192369
79MP0002429_abnormal_blood_cell1.30576240
80MP0000569_abnormal_digit_pigmentation1.30135826
81MP0009333_abnormal_splenocyte_physiolog1.30121881
82MP0003566_abnormal_cell_adhesion1.29013202
83MP0010307_abnormal_tumor_latency1.24691587
84MP0003111_abnormal_nucleus_morphology1.22798574
85MP0005380_embryogenesis_phenotype1.22774185
86MP0001672_abnormal_embryogenesis/_devel1.22774185
87MP0002009_preneoplasia1.22228014
88MP0009764_decreased_sensitivity_to1.22039597
89MP0000685_abnormal_immune_system1.21960115
90MP0004264_abnormal_extraembryonic_tissu1.20888818
91MP0003705_abnormal_hypodermis_morpholog1.20308320
92MP0004233_abnormal_muscle_weight1.19678352
93MP0004185_abnormal_adipocyte_glucose1.17720759
94MP0003123_paternal_imprinting1.15371030
95MP0005075_abnormal_melanosome_morpholog1.15262302
96MP0003866_abnormal_defecation1.14870652
97MP0000371_diluted_coat_color1.14683509
98MP0005076_abnormal_cell_differentiation1.13306891
99MP0002998_abnormal_bone_remodeling1.11781666
100MP0004085_abnormal_heartbeat1.08870863
101MP0005670_abnormal_white_adipose1.08352838
102MP0005375_adipose_tissue_phenotype1.07909786
103MP0000747_muscle_weakness1.07690931
104MP0002877_abnormal_melanocyte_morpholog1.07213262
105MP0002928_abnormal_bile_duct1.06448491
106MP0000858_altered_metastatic_potential1.06439647
107MP0009278_abnormal_bone_marrow1.05949151
108MP0008057_abnormal_DNA_replication1.04524668
109MP0001730_embryonic_growth_arrest1.03543925
110MP0003453_abnormal_keratinocyte_physiol1.03338562
111MP0004147_increased_porphyrin_level1.03337515
112MP0003172_abnormal_lysosome_physiology1.02566568
113MP0001873_stomach_inflammation1.02525479
114MP0002086_abnormal_extraembryonic_tissu1.02170957
115MP0005187_abnormal_penis_morphology1.00243964
116MP0005167_abnormal_blood-brain_barrier0.99871370
117MP0001727_abnormal_embryo_implantation0.99043869
118MP0001697_abnormal_embryo_size0.98921045
119MP0010678_abnormal_skin_adnexa0.97907973
120MP0000350_abnormal_cell_proliferation0.97121203
121MP0003763_abnormal_thymus_physiology0.96901820
122MP0001879_abnormal_lymphatic_vessel0.96833373
123MP0005369_muscle_phenotype0.96755875
124MP0000537_abnormal_urethra_morphology0.96569050
125MP0009672_abnormal_birth_weight0.96483146
126MP0005248_abnormal_Harderian_gland0.96385206
127MP0003195_calcinosis0.96262896
128MP0003252_abnormal_bile_duct0.95887520
129MP0004957_abnormal_blastocyst_morpholog0.95279056
130MP0002006_tumorigenesis0.94307075
131MP0002925_abnormal_cardiovascular_devel0.93331343
132MP0010368_abnormal_lymphatic_system0.92900161
133MP0000372_irregular_coat_pigmentation0.92850404
134MP0001191_abnormal_skin_condition0.92781344
135MP0005310_abnormal_salivary_gland0.92474239
136MP0004197_abnormal_fetal_growth/weight/0.92283290
137MP0003943_abnormal_hepatobiliary_system0.89985588
138MP0002127_abnormal_cardiovascular_syste0.86901520
139MP0000733_abnormal_muscle_development0.86873591
140MP0005451_abnormal_body_composition0.86731387
141MP0000490_abnormal_crypts_of0.86298381
142MP0000343_altered_response_to0.86053238
143MP0002234_abnormal_pharynx_morphology0.85302773
144MP0008469_abnormal_protein_level0.84329735
145MP0005377_hearing/vestibular/ear_phenot0.84037338
146MP0003878_abnormal_ear_physiology0.84037338
147MP0000759_abnormal_skeletal_muscle0.83879821
148MP0002080_prenatal_lethality0.82547770
149MP0002084_abnormal_developmental_patter0.82497557
150MP0001216_abnormal_epidermal_layer0.81316268
151MP0006036_abnormal_mitochondrial_physio0.80535214
152MP0008058_abnormal_DNA_repair0.80188531
153MP0003787_abnormal_imprinting0.80030366
154MP0000383_abnormal_hair_follicle0.78776326
155MP0000003_abnormal_adipose_tissue0.78719808
156* MP0009763_increased_sensitivity_to0.78522094
157MP0009053_abnormal_anal_canal0.78172513
158MP0005058_abnormal_lysosome_morphology0.78021156
159MP0001853_heart_inflammation0.77926874
160MP0002277_abnormal_respiratory_mucosa0.77758842
161MP0003075_altered_response_to0.77543877
162MP0005174_abnormal_tail_pigmentation0.77508603
163MP0008877_abnormal_DNA_methylation0.75887852
164* MP0009765_abnormal_xenobiotic_induced0.75518809
165MP0002128_abnormal_blood_circulation0.75055387
166MP0001270_distended_abdomen0.74443400
167MP0002138_abnormal_hepatobiliary_system0.74319841
168MP0001545_abnormal_hematopoietic_system0.74093326
169MP0005397_hematopoietic_system_phenotyp0.74093326
170MP0003121_genomic_imprinting0.73346519
171MP0000703_abnormal_thymus_morphology0.73098956
172MP0001756_abnormal_urination0.72708941
173MP0003091_abnormal_cell_migration0.70396934
174MP0005621_abnormal_cell_physiology0.69565844
175MP0000015_abnormal_ear_pigmentation0.68145679
176MP0003690_abnormal_glial_cell0.67877946
177MP0004510_myositis0.64264338

Predicted human phenotypes

RankGene SetZ-score
1T lymphocytopenia (HP:0005403)5.98457929
2Abnormality of T cell number (HP:0011839)5.37144347
3Recurrent bacterial skin infections (HP:0005406)4.89756576
4Eczematoid dermatitis (HP:0000976)4.88069998
5Sudden death (HP:0001699)4.64106586
6Recurrent abscess formation (HP:0002722)4.31931023
7Ventricular tachycardia (HP:0004756)4.30777127
8Atrial fibrillation (HP:0005110)4.13848507
9Abnormality of macrophages (HP:0004311)4.10282254
10Optic neuritis (HP:0100653)4.00671976
11Retrobulbar optic neuritis (HP:0100654)4.00671976
12Primary atrial arrhythmia (HP:0001692)3.92855092
13Stomatitis (HP:0010280)3.86648326
14Supraventricular tachycardia (HP:0004755)3.80264849
15Supraventricular arrhythmia (HP:0005115)3.73503528
16Orchitis (HP:0100796)3.70749362
17Right ventricular cardiomyopathy (HP:0011663)3.62727307
18Myositis (HP:0100614)3.45533316
19Lipoatrophy (HP:0100578)3.33716127
20Bundle branch block (HP:0011710)3.24796674
21Keratoconjunctivitis sicca (HP:0001097)3.24020751
22Palpitations (HP:0001962)3.22186419
23Abnormality of the left ventricular outflow tract (HP:0011103)3.17794704
24Subaortic stenosis (HP:0001682)3.17794704
25Exercise-induced muscle cramps (HP:0003710)3.12938084
26Gingivitis (HP:0000230)3.12695723
27Myoglobinuria (HP:0002913)3.11417338
28Syncope (HP:0001279)3.09643718
29Abnormality of the fingertips (HP:0001211)3.08564468
30Abnormality of T cells (HP:0002843)3.01781882
31Recurrent fungal infections (HP:0002841)2.98944238
32Keratoconjunctivitis (HP:0001096)2.92483804
33Recurrent skin infections (HP:0001581)2.91069997
34Dilated cardiomyopathy (HP:0001644)2.88394738
35Recurrent viral infections (HP:0004429)2.87731671
36Muscle fiber splitting (HP:0003555)2.86958430
37Leukocytosis (HP:0001974)2.84036706
38Rectal prolapse (HP:0002035)2.82642051
39Papillary thyroid carcinoma (HP:0002895)2.81456673
40Gangrene (HP:0100758)2.78422346
41Calf muscle hypertrophy (HP:0008981)2.78034912
42Prolonged QT interval (HP:0001657)2.76363435
43Gastrointestinal infarctions (HP:0005244)2.76216956
44Hypoplastic ischia (HP:0003175)2.75594678
45Abnormality of the calf musculature (HP:0001430)2.72588778
46Recurrent gram-negative bacterial infections (HP:0005420)2.70797895
47Mediastinal lymphadenopathy (HP:0100721)2.69450231
48Limb-girdle muscle atrophy (HP:0003797)2.69283470
49Ventricular fibrillation (HP:0001663)2.67111222
50Thick nail (HP:0001805)2.65860907
51Abnormal delayed hypersensitivity skin test (HP:0002963)2.63842571
52Autoimmune hemolytic anemia (HP:0001890)2.61416619
53Encephalitis (HP:0002383)2.61393891
54Abnormality of eosinophils (HP:0001879)2.60970865
55Metaphyseal cupping (HP:0003021)2.60955860
56Pustule (HP:0200039)2.57363169
57Cerebral aneurysm (HP:0004944)2.57142061
58Ventricular arrhythmia (HP:0004308)2.56852071
59Lymphangioma (HP:0100764)2.56323109
60Exercise-induced myalgia (HP:0003738)2.55764519
61Rhabdomyolysis (HP:0003201)2.54480542
62Autoimmune thrombocytopenia (HP:0001973)2.53206993
63Curly hair (HP:0002212)2.52826246
64Chronic mucocutaneous candidiasis (HP:0002728)2.52501306
65Recurrent cutaneous fungal infections (HP:0011370)2.52501306
66Spontaneous hematomas (HP:0007420)2.48948898
67Aortic aneurysm (HP:0004942)2.44746086
68Increased connective tissue (HP:0009025)2.43694525
69Hemoptysis (HP:0002105)2.38862381
70Hematochezia (HP:0002573)2.38423781
71Combined immunodeficiency (HP:0005387)2.35335311
72Disinhibition (HP:0000734)2.34886381
73Premature loss of primary teeth (HP:0006323)2.34688356
74Neoplasm of the small intestine (HP:0100833)2.34573468
75Abnormality of the ischium (HP:0003174)2.34128507
76Hyporeflexia of lower limbs (HP:0002600)2.30878392
77Chest pain (HP:0100749)2.30868263
78Meningitis (HP:0001287)2.30255232
79Subacute progressive viral hepatitis (HP:0006572)2.30240258
80Atrioventricular block (HP:0001678)2.29979139
81Thyroid carcinoma (HP:0002890)2.29891068
82Abnormality of fatty-acid metabolism (HP:0004359)2.29293543
83Heart block (HP:0012722)2.28783407
84Elfin facies (HP:0004428)2.26379860
85Eosinophilia (HP:0001880)2.26230681
86Obstructive lung disease (HP:0006536)2.26042203
87Chronic obstructive pulmonary disease (HP:0006510)2.26042203
88Episodic fever (HP:0001954)2.25846565
89Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.25676649
90Neoplasm of the rectum (HP:0100743)2.25558825
91Vasculitis (HP:0002633)2.23899768
92Hypoglycemic coma (HP:0001325)2.23462299
93Intestinal atresia (HP:0011100)2.22911502
94Ketoacidosis (HP:0001993)2.22776711
95Arterial thrombosis (HP:0004420)2.21791202
96Pulmonary infiltrates (HP:0002113)2.21148688
97Volvulus (HP:0002580)2.18700734
98Neoplasm of the tracheobronchial system (HP:0100552)2.18521356
99Severe combined immunodeficiency (HP:0004430)2.17855918
100Elevated erythrocyte sedimentation rate (HP:0003565)2.15847061
101Asymmetric septal hypertrophy (HP:0001670)2.14281884
102Agnosia (HP:0010524)2.13620789
103Urticaria (HP:0001025)2.12992904
104Colon cancer (HP:0003003)2.12198559
105Neoplasm of the adrenal gland (HP:0100631)2.12020299
106Proximal amyotrophy (HP:0007126)2.11712989
107Abnormal atrioventricular conduction (HP:0005150)2.11176574
108Facial diplegia (HP:0001349)2.10784664
109Skull defect (HP:0001362)2.10444099
110Granulocytopenia (HP:0001913)2.09757010
111Joint swelling (HP:0001386)2.09503287
112Muscle hypertrophy of the lower extremities (HP:0008968)2.09447064
113Abnormal EKG (HP:0003115)2.08943462
114Biliary tract neoplasm (HP:0100574)2.08722074
115Bicuspid aortic valve (HP:0001647)2.08423654
116Periodontitis (HP:0000704)2.08331775
117Conjunctival hamartoma (HP:0100780)2.07079193
118Amaurosis fugax (HP:0100576)2.05142372
119Generalized aminoaciduria (HP:0002909)2.01389909
120Hyperacusis (HP:0010780)2.01137944
121Increased IgM level (HP:0003496)1.98029611
122Dysautonomia (HP:0002459)1.97702476
123Lymphopenia (HP:0001888)1.97019892
124Anorexia (HP:0002039)1.96550413
125Thyroiditis (HP:0100646)1.96518102
126Hyperactive renin-angiotensin system (HP:0000841)1.95934086
127Difficulty running (HP:0009046)1.95600292
128Flat acetabular roof (HP:0003180)1.94802593
129Alveolar cell carcinoma (HP:0006519)1.94667874
130Amyotrophic lateral sclerosis (HP:0007354)1.94504762
131Abnormal hair whorl (HP:0010721)1.93220397
132Neonatal death (HP:0003811)1.91985712
133Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.90952657
134Short 4th metacarpal (HP:0010044)1.90952657
135IgG deficiency (HP:0004315)1.90735384
136Abnormality of cells of the lymphoid lineage (HP:0012140)1.90423812
137Freckling (HP:0001480)1.90341325
138Meningioma (HP:0002858)1.89423561
139Rimmed vacuoles (HP:0003805)1.87965962
140Ependymoma (HP:0002888)1.87548539
141Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.87218037
142Abnormality of alanine metabolism (HP:0010916)1.87218037
143Hyperalaninemia (HP:0003348)1.87218037
144Hamartoma of the eye (HP:0010568)1.86810346
145IgM deficiency (HP:0002850)1.85743188
146Gingival bleeding (HP:0000225)1.85301379
147Macroorchidism (HP:0000053)1.84869742
148Pulmonary embolism (HP:0002204)1.84530541
149Medulloblastoma (HP:0002885)1.84483014
150Chronic diarrhea (HP:0002028)1.83454818
151Epiphyseal dysplasia (HP:0002656)1.82754229
152Abnormality of the 4th metacarpal (HP:0010012)1.81185893
153Broad palm (HP:0001169)1.79292820
154Increased IgE level (HP:0003212)1.78999550
155Proximal tubulopathy (HP:0000114)1.78070959
156Enlarged penis (HP:0000040)1.76315043
157Abnormality of glycolipid metabolism (HP:0010969)1.76166588
158Abnormality of liposaccharide metabolism (HP:0010968)1.76166588
159Abnormality of glycosphingolipid metabolism (HP:0004343)1.76166588
160Exostoses (HP:0100777)1.76091685
161Transitional cell carcinoma of the bladder (HP:0006740)1.74149275
162Keratitis (HP:0000491)1.73969227
163Esophageal varix (HP:0002040)1.73648087
164Pancreatic islet-cell hyperplasia (HP:0004510)1.72893756
165Uterine neoplasm (HP:0010784)1.71976210
166Abnormality of the endocardium (HP:0004306)1.71468467
167Sepsis (HP:0100806)1.71040393
168Long clavicles (HP:0000890)1.70904394
169EMG: myopathic abnormalities (HP:0003458)1.70665542
170Abnormality of the pleura (HP:0002103)1.69568429
171Sudden cardiac death (HP:0001645)1.69405721
172Ovarian neoplasm (HP:0100615)1.69380894
173High pitched voice (HP:0001620)1.68947787
174Scapular winging (HP:0003691)1.68301058
175Increased CSF protein (HP:0002922)1.68240922
176Abnormal pancreas size (HP:0012094)1.68091047
177Distal lower limb muscle weakness (HP:0009053)1.66904424
178Malignant gastrointestinal tract tumors (HP:0006749)1.65302621
179Gastrointestinal carcinoma (HP:0002672)1.65302621
180Hypokalemic alkalosis (HP:0001949)1.64391261
181Abnormal foot bone ossification (HP:0010675)1.64298255
182Germ cell neoplasia (HP:0100728)1.63957024
183Hyperglycinuria (HP:0003108)1.63830813
184Cutis marmorata (HP:0000965)1.63458016
185Hypercalciuria (HP:0002150)1.63086539
186Hyperuricemia (HP:0002149)1.62799212
187Increased purine levels (HP:0004368)1.62799212
188Osteomyelitis (HP:0002754)1.62738970
189Blue irides (HP:0000635)1.62699242
190Abnormality of chloride homeostasis (HP:0011422)1.62307561
191Interstitial pulmonary disease (HP:0006530)1.62283598
192Slow saccadic eye movements (HP:0000514)1.60816032
193Abnormality of nail color (HP:0100643)1.60238493
194Aplasia cutis congenita (HP:0001057)1.60091697
195Truncal obesity (HP:0001956)1.59945649
196Amyloidosis (HP:0011034)1.58923425
197Dysmetric saccades (HP:0000641)1.58040437

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TXK4.34404330
2PKN24.07051572
3TRIB33.40161545
4TGFBR23.16727112
5MAP3K143.05820444
6LMTK22.98718070
7TTN2.79164998
8EEF2K2.66248496
9CSK2.52504665
10EPHA32.38157766
11MATK2.38141538
12PDK32.35440832
13PDK42.35440832
14MAP3K102.26787884
15RIPK42.18434587
16BCR2.16741753
17FGR2.16163257
18NEK12.12115857
19BLK2.03931093
20IRAK42.00513805
21IRAK11.97219365
22PDK21.92655793
23STK241.88149630
24FES1.75628628
25FLT31.73114176
26TAOK31.67763899
27ZAP701.67236572
28TGFBR11.67020204
29YES11.65400607
30IRAK21.63021082
31MAP2K31.58080741
32KSR11.53984233
33IKBKE1.50681096
34CDC71.49781684
35MAP3K21.47838309
36NEK91.45498115
37TYK21.43890672
38OBSCN1.40661270
39ACVR1B1.40465401
40MAP3K31.38687649
41TRIM281.38665174
42TIE11.31675367
43PTK61.31335963
44CDK61.31109523
45BTK1.28396898
46LATS11.28177686
47BCKDK1.27904362
48MARK31.27371612
49JAK21.24914233
50JAK11.23123466
51JAK31.22681770
52ERBB31.21278015
53MAPKAPK31.20328104
54DMPK1.20172770
55IRAK31.18308396
56NEK61.17252638
57LCK1.16471222
58GRK61.14044289
59MAP4K11.13019057
60OXSR11.11702128
61BMPR21.07838073
62CDK41.07647378
63HCK1.07565853
64KDR1.07453922
65LYN1.07279567
66ITK1.05911309
67FGFR31.05667346
68KSR21.05026482
69TSSK61.01969871
70FRK1.01825726
71MST40.99208136
72CAMK1D0.99092353
73BRSK20.98806318
74MAPK150.98647531
75NEK20.97723616
76ERBB20.97346206
77RPS6KA40.96873162
78MYLK0.96498341
79STK40.95471636
80WNK40.95049027
81RIPK10.94875059
82STK100.94391187
83CDK120.93138927
84STK38L0.93019483
85WNK30.91042246
86PAK40.90955023
87GRK70.90355287
88SYK0.89771585
89PASK0.89274458
90RET0.89155228
91EPHB10.88574151
92MAP3K70.88563078
93ATR0.87098791
94PHKG10.85533024
95PHKG20.85533024
96SCYL20.84656367
97PDGFRA0.82134973
98RPS6KB20.81327535
99STK30.80925187
100PDGFRB0.79112454
101MTOR0.78785140
102TBK10.78338923
103SGK30.75421465
104PRKAA10.74563071
105LRRK20.74288355
106CSF1R0.74167961
107IKBKB0.73991321
108TAOK10.72760837
109MAP3K10.72219140
110CAMK40.70966221
111WNK10.68939624
112PIK3CA0.67828362
113FYN0.67609363
114TTK0.66976447
115ILK0.65820041
116WEE10.65330154
117AURKB0.62692931
118DYRK1B0.62547310
119CCNB10.62278688
120PRKAA20.61756741
121MKNK20.60993952
122ZAK0.60838233
123SRPK10.60421135
124PIM10.59897466
125MAP3K40.59707497
126DYRK30.59657868
127FER0.58888565
128EGFR0.58706193
129TRPM70.58071855
130BRSK10.57844269
131BRD40.57736550
132MKNK10.57455977
133FGFR40.57409776
134MAP3K50.57206589
135RAF10.56988171
136MAP3K60.54432613
137NLK0.52926997
138MAPK110.52479701
139SIK30.52344384
140RPS6KL10.51980512
141RPS6KC10.51980512
142SGK20.51964536
143FGFR20.51503010
144PRKD10.50428479
145NUAK10.50186308
146FGFR10.49909833
147CHUK0.49543806
148PRKCQ0.47791034
149TEC0.47252972
150CLK10.47125660
151MELK0.46906511
152ATM0.46700129
153KIT0.45948803
154ERN10.45756884
155CHEK10.45309368
156INSR0.44330128
157RPS6KA60.44104253
158PAK20.43465968
159CDK90.43259042
160MAP4K20.42341776
161IGF1R0.41444276
162MAP3K130.39393054
163PRPF4B0.33902995
164ALK0.33390174
165BMPR1B0.33355841
166NTRK10.31115268
167DAPK20.29872236

Predicted pathways (KEGG)

RankGene SetZ-score
1Citrate cycle (TCA cycle)_Homo sapiens_hsa000205.04294951
22-Oxocarboxylic acid metabolism_Homo sapiens_hsa012103.52371379
3Propanoate metabolism_Homo sapiens_hsa006402.54375683
4Fatty acid degradation_Homo sapiens_hsa000712.27920814
5Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.27180732
6NF-kappa B signaling pathway_Homo sapiens_hsa040642.24736451
7Lysine degradation_Homo sapiens_hsa003102.19780884
8NOD-like receptor signaling pathway_Homo sapiens_hsa046212.19075867
9Toll-like receptor signaling pathway_Homo sapiens_hsa046202.18825636
10DNA replication_Homo sapiens_hsa030302.00445373
11Measles_Homo sapiens_hsa051621.96756766
12Primary immunodeficiency_Homo sapiens_hsa053401.83893643
13Dilated cardiomyopathy_Homo sapiens_hsa054141.83439612
14Carbon metabolism_Homo sapiens_hsa012001.80554890
15Salmonella infection_Homo sapiens_hsa051321.79045459
16Hematopoietic cell lineage_Homo sapiens_hsa046401.78284710
17Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.75767462
18Viral myocarditis_Homo sapiens_hsa054161.72239652
19Chemokine signaling pathway_Homo sapiens_hsa040621.71260037
20Graft-versus-host disease_Homo sapiens_hsa053321.67198117
21TNF signaling pathway_Homo sapiens_hsa046681.65732712
22Tuberculosis_Homo sapiens_hsa051521.61339978
23Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.59537917
24Chronic myeloid leukemia_Homo sapiens_hsa052201.57724169
25Staphylococcus aureus infection_Homo sapiens_hsa051501.56557619
26Base excision repair_Homo sapiens_hsa034101.53730793
27Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.52260580
28Insulin resistance_Homo sapiens_hsa049311.48526137
29Cell cycle_Homo sapiens_hsa041101.46213622
30Small cell lung cancer_Homo sapiens_hsa052221.45011808
31Mismatch repair_Homo sapiens_hsa034301.44358589
32Fatty acid metabolism_Homo sapiens_hsa012121.44051980
33Malaria_Homo sapiens_hsa051441.43539327
34RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.39674012
35Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.37903118
36Rheumatoid arthritis_Homo sapiens_hsa053231.36684355
37Shigellosis_Homo sapiens_hsa051311.35973485
38Jak-STAT signaling pathway_Homo sapiens_hsa046301.33806784
39Adherens junction_Homo sapiens_hsa045201.32648594
40mRNA surveillance pathway_Homo sapiens_hsa030151.31668267
41Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.28471269
42Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.28048456
43Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.26904649
44Spliceosome_Homo sapiens_hsa030401.26508584
45Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.20102550
46Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.19381794
47Allograft rejection_Homo sapiens_hsa053301.18781771
48Thyroid hormone signaling pathway_Homo sapiens_hsa049191.17221150
49Endometrial cancer_Homo sapiens_hsa052131.15010306
50Autoimmune thyroid disease_Homo sapiens_hsa053201.14931686
51Non-small cell lung cancer_Homo sapiens_hsa052231.14840391
52* Influenza A_Homo sapiens_hsa051641.12887527
53Colorectal cancer_Homo sapiens_hsa052101.12109643
54mTOR signaling pathway_Homo sapiens_hsa041501.10473659
55Pancreatic cancer_Homo sapiens_hsa052121.08094042
56B cell receptor signaling pathway_Homo sapiens_hsa046621.07045487
57Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.06246670
58Insulin signaling pathway_Homo sapiens_hsa049101.05387642
59Lysosome_Homo sapiens_hsa041421.04370967
60Toxoplasmosis_Homo sapiens_hsa051451.04248631
61AMPK signaling pathway_Homo sapiens_hsa041521.04223272
62MicroRNAs in cancer_Homo sapiens_hsa052061.04013188
63Renal cell carcinoma_Homo sapiens_hsa052111.03178142
64Amoebiasis_Homo sapiens_hsa051461.00636106
65Phagosome_Homo sapiens_hsa041451.00622917
66Pertussis_Homo sapiens_hsa051331.00592319
67Pyruvate metabolism_Homo sapiens_hsa006200.99002805
68HTLV-I infection_Homo sapiens_hsa051660.96559097
69Hepatitis C_Homo sapiens_hsa051600.95519796
70RNA transport_Homo sapiens_hsa030130.95267147
71Transcriptional misregulation in cancer_Homo sapiens_hsa052020.95060207
72Glucagon signaling pathway_Homo sapiens_hsa049220.94756194
73Central carbon metabolism in cancer_Homo sapiens_hsa052300.94022476
74Focal adhesion_Homo sapiens_hsa045100.90653668
75Leukocyte transendothelial migration_Homo sapiens_hsa046700.89008110
76FoxO signaling pathway_Homo sapiens_hsa040680.88385493
77Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.87723390
78Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.87511792
79Notch signaling pathway_Homo sapiens_hsa043300.85285821
80Longevity regulating pathway - mammal_Homo sapiens_hsa042110.84560465
81cGMP-PKG signaling pathway_Homo sapiens_hsa040220.84551540
82Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.84113653
83Biosynthesis of amino acids_Homo sapiens_hsa012300.83818875
84Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.83787330
85HIF-1 signaling pathway_Homo sapiens_hsa040660.83114128
86Platelet activation_Homo sapiens_hsa046110.83107111
87Dorso-ventral axis formation_Homo sapiens_hsa043200.82646045
88Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.82414611
89Thyroid cancer_Homo sapiens_hsa052160.82242219
90Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.81908448
91Non-homologous end-joining_Homo sapiens_hsa034500.80041836
92Osteoclast differentiation_Homo sapiens_hsa043800.79560870
93Protein digestion and absorption_Homo sapiens_hsa049740.79288453
94Type I diabetes mellitus_Homo sapiens_hsa049400.79137760
95Viral carcinogenesis_Homo sapiens_hsa052030.77774386
96Bladder cancer_Homo sapiens_hsa052190.77163145
97AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.76365202
98Acute myeloid leukemia_Homo sapiens_hsa052210.75941521
99Carbohydrate digestion and absorption_Homo sapiens_hsa049730.74955107
100Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.74034151
101Epstein-Barr virus infection_Homo sapiens_hsa051690.73439639
102p53 signaling pathway_Homo sapiens_hsa041150.72952219
103Neurotrophin signaling pathway_Homo sapiens_hsa047220.72553885
104Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.72306423
105Selenocompound metabolism_Homo sapiens_hsa004500.72225040
106Adipocytokine signaling pathway_Homo sapiens_hsa049200.71690011
107Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.71391717
108Endocytosis_Homo sapiens_hsa041440.71193080
109Herpes simplex infection_Homo sapiens_hsa051680.70560508
110Proteoglycans in cancer_Homo sapiens_hsa052050.68723996
111Hepatitis B_Homo sapiens_hsa051610.67632042
112Other glycan degradation_Homo sapiens_hsa005110.67343176
113Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.67042065
114Choline metabolism in cancer_Homo sapiens_hsa052310.66683617
115Legionellosis_Homo sapiens_hsa051340.64892427
116Antigen processing and presentation_Homo sapiens_hsa046120.64112638
117Sphingolipid signaling pathway_Homo sapiens_hsa040710.63459582
118Starch and sucrose metabolism_Homo sapiens_hsa005000.62778716
119Cardiac muscle contraction_Homo sapiens_hsa042600.62319246
120ErbB signaling pathway_Homo sapiens_hsa040120.60363282
121ECM-receptor interaction_Homo sapiens_hsa045120.60333083
122Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.58689190
123Type II diabetes mellitus_Homo sapiens_hsa049300.55057457
124Hippo signaling pathway_Homo sapiens_hsa043900.54773925
125Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.54079153
126Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.51746227
127PPAR signaling pathway_Homo sapiens_hsa033200.51724180
128Pathways in cancer_Homo sapiens_hsa052000.51011207
129N-Glycan biosynthesis_Homo sapiens_hsa005100.50856381
130African trypanosomiasis_Homo sapiens_hsa051430.50105894
131Phosphatidylinositol signaling system_Homo sapiens_hsa040700.49085609
132VEGF signaling pathway_Homo sapiens_hsa043700.47699757
133Rap1 signaling pathway_Homo sapiens_hsa040150.47305950
134Sphingolipid metabolism_Homo sapiens_hsa006000.47148576
135Regulation of actin cytoskeleton_Homo sapiens_hsa048100.46930137
136Inositol phosphate metabolism_Homo sapiens_hsa005620.46859606
137Olfactory transduction_Homo sapiens_hsa047400.46028629
138Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.44979748
139RNA degradation_Homo sapiens_hsa030180.44590378
140Apoptosis_Homo sapiens_hsa042100.44060076
141Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.43492361
142T cell receptor signaling pathway_Homo sapiens_hsa046600.42389266
143Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.41954701
144Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.41948695
145Prolactin signaling pathway_Homo sapiens_hsa049170.41492526
146Prostate cancer_Homo sapiens_hsa052150.41223654
147Circadian rhythm_Homo sapiens_hsa047100.40845709
148Phospholipase D signaling pathway_Homo sapiens_hsa040720.40832145
149One carbon pool by folate_Homo sapiens_hsa006700.40823160
150Leishmaniasis_Homo sapiens_hsa051400.40615496
151Prion diseases_Homo sapiens_hsa050200.39883989
152Nucleotide excision repair_Homo sapiens_hsa034200.39085164
153Glioma_Homo sapiens_hsa052140.38894020
154Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.38842767

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