IYD

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes an enzyme that catalyzes the oxidative NADPH-dependent deiodination of mono- and diiodotyrosine, which are the halogenated byproducts of thyroid hormone production. The N-terminus of the protein functions as a membrane anchor. Mutations in this gene cause congenital hypothyroidism due to dyshormonogenesis type 4, which is also referred to as deiodinase deficiency, or iodotyrosine dehalogenase deficiency, or thyroid hormonogenesis type 4. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1sulfate transmembrane transport (GO:1902358)7.45866929
2L-phenylalanine catabolic process (GO:0006559)7.39487363
3erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)7.39487363
4L-phenylalanine metabolic process (GO:0006558)7.07256992
5erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)7.07256992
6aromatic amino acid family catabolic process (GO:0009074)6.63588363
7sulfate transport (GO:0008272)6.24187730
8triglyceride-rich lipoprotein particle remodeling (GO:0034370)6.03555227
9tryptophan catabolic process (GO:0006569)5.98082712
10indole-containing compound catabolic process (GO:0042436)5.98082712
11indolalkylamine catabolic process (GO:0046218)5.98082712
12kynurenine metabolic process (GO:0070189)5.84604192
13bile acid biosynthetic process (GO:0006699)5.72123312
14glyoxylate metabolic process (GO:0046487)5.69251593
15tryptophan metabolic process (GO:0006568)5.62346830
16thyroid gland development (GO:0030878)5.59694778
17urea metabolic process (GO:0019627)5.45212842
18urea cycle (GO:0000050)5.45212842
19alpha-linolenic acid metabolic process (GO:0036109)5.38207640
20cysteine metabolic process (GO:0006534)5.35458337
21negative regulation of fibrinolysis (GO:0051918)5.26773893
22high-density lipoprotein particle remodeling (GO:0034375)5.26646981
23sulfur amino acid catabolic process (GO:0000098)5.26476166
24epoxygenase P450 pathway (GO:0019373)5.21240597
25protein carboxylation (GO:0018214)5.13709934
26peptidyl-glutamic acid carboxylation (GO:0017187)5.13709934
27regulation of fibrinolysis (GO:0051917)5.04392424
28nitrogen cycle metabolic process (GO:0071941)5.03231064
29complement activation, alternative pathway (GO:0006957)5.00066812
30serine family amino acid catabolic process (GO:0009071)4.95848685
31regulation of protein activation cascade (GO:2000257)4.94375483
32bile acid metabolic process (GO:0008206)4.88754254
33fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.86163965
34lysine metabolic process (GO:0006553)4.83421060
35lysine catabolic process (GO:0006554)4.83421060
36aromatic amino acid family metabolic process (GO:0009072)4.79840705
37homocysteine metabolic process (GO:0050667)4.69871580
38regulation of cholesterol esterification (GO:0010872)4.69060393
39amino-acid betaine metabolic process (GO:0006577)4.68242111
40* thyroid hormone generation (GO:0006590)4.67624871
41regulation of triglyceride catabolic process (GO:0010896)4.61165331
42regulation of complement activation (GO:0030449)4.61090261
43reverse cholesterol transport (GO:0043691)4.57140498
44tyrosine metabolic process (GO:0006570)4.56378726
45alpha-amino acid catabolic process (GO:1901606)4.54840616
46protein-lipid complex remodeling (GO:0034368)4.52872308
47macromolecular complex remodeling (GO:0034367)4.52872308
48plasma lipoprotein particle remodeling (GO:0034369)4.52872308
49negative regulation of cholesterol transport (GO:0032375)4.46385854
50negative regulation of sterol transport (GO:0032372)4.46385854
51cellular ketone body metabolic process (GO:0046950)4.45850509
52phospholipid efflux (GO:0033700)4.36320299
53triglyceride homeostasis (GO:0070328)4.33716577
54acylglycerol homeostasis (GO:0055090)4.33716577
55drug metabolic process (GO:0017144)4.32739109
56oxidative demethylation (GO:0070989)4.29609180
57cellular amino acid catabolic process (GO:0009063)4.22311864
58drug catabolic process (GO:0042737)4.21753741
59indolalkylamine metabolic process (GO:0006586)4.21029594
60bile acid and bile salt transport (GO:0015721)4.19436865
61glutamate metabolic process (GO:0006536)4.19158575
62coenzyme catabolic process (GO:0009109)4.17977697
63cellular glucuronidation (GO:0052695)4.17264319
64glycine metabolic process (GO:0006544)4.16467337
65plasma lipoprotein particle clearance (GO:0034381)4.15957558
66regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:00033394.12764383
67ethanol oxidation (GO:0006069)4.12306927
68cellular biogenic amine catabolic process (GO:0042402)4.10014721
69amine catabolic process (GO:0009310)4.10014721
70cellular modified amino acid catabolic process (GO:0042219)4.09740411
71serine family amino acid metabolic process (GO:0009069)4.08658771
72benzene-containing compound metabolic process (GO:0042537)4.05775966
73cholesterol efflux (GO:0033344)4.02753758
74omega-hydroxylase P450 pathway (GO:0097267)4.01577180
75dicarboxylic acid biosynthetic process (GO:0043650)4.00417285
76* thyroid hormone metabolic process (GO:0042403)3.99492154
77imidazole-containing compound metabolic process (GO:0052803)3.96809003
78arginine metabolic process (GO:0006525)3.89521605
79serine family amino acid biosynthetic process (GO:0009070)3.88477006
80aldehyde catabolic process (GO:0046185)3.88424517
81ketone body metabolic process (GO:1902224)3.85239369
82short-chain fatty acid metabolic process (GO:0046459)3.83623157
83alkaloid metabolic process (GO:0009820)3.83012224
84low-density lipoprotein particle remodeling (GO:0034374)3.80455249
85plasma lipoprotein particle assembly (GO:0034377)3.80411467
86glucuronate metabolic process (GO:0019585)3.75345408
87uronic acid metabolic process (GO:0006063)3.75345408
88fibrinolysis (GO:0042730)3.74339570
89S-adenosylmethionine metabolic process (GO:0046500)3.72478220
90positive regulation of triglyceride lipase activity (GO:0061365)3.72234242
91positive regulation of lipoprotein lipase activity (GO:0051006)3.72234242
92carboxylic acid catabolic process (GO:0046395)3.70782921
93organic acid catabolic process (GO:0016054)3.70782921
94sulfur compound transport (GO:0072348)3.68638533
95exogenous drug catabolic process (GO:0042738)3.68391348
96acetyl-CoA metabolic process (GO:0006084)3.65349560
97cholesterol homeostasis (GO:0042632)3.64140435
98aspartate family amino acid catabolic process (GO:0009068)3.64081707
99regulation of bile acid biosynthetic process (GO:0070857)3.62524513
100positive regulation of lipid catabolic process (GO:0050996)3.62180361
101flavonoid metabolic process (GO:0009812)3.61466968
102cofactor catabolic process (GO:0051187)3.59511387
103negative regulation of lipase activity (GO:0060192)3.59375349
104sterol homeostasis (GO:0055092)3.59147316
105drug transmembrane transport (GO:0006855)3.58886147
106very-low-density lipoprotein particle assembly (GO:0034379)3.58089400
107regulation of plasminogen activation (GO:0010755)3.57999303
108regulation of cholesterol homeostasis (GO:2000188)3.55720218
109urate metabolic process (GO:0046415)3.54060951
110phospholipid homeostasis (GO:0055091)3.51636933
111blood coagulation, intrinsic pathway (GO:0007597)3.50271125
112phenylpropanoid metabolic process (GO:0009698)3.37017645
113hormone biosynthetic process (GO:0042446)3.32854543
114detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.29130679
115cellular response to gonadotropin stimulus (GO:0071371)3.23954835
116sulfation (GO:0051923)3.22663869
117nephron tubule formation (GO:0072079)3.22448267
118hormone catabolic process (GO:0042447)3.15098382
119heme transport (GO:0015886)3.00370069
120L-fucose catabolic process (GO:0042355)2.99896519
121fucose catabolic process (GO:0019317)2.99896519
122L-fucose metabolic process (GO:0042354)2.99896519
123regulation of lipoprotein metabolic process (GO:0050746)2.98402151
124indole-containing compound metabolic process (GO:0042430)2.91222442
125amino acid salvage (GO:0043102)2.91179917
126L-methionine salvage (GO:0071267)2.91179917
127L-methionine biosynthetic process (GO:0071265)2.91179917
128positive regulation of fatty acid transport (GO:2000193)2.90287620
129* phenol-containing compound metabolic process (GO:0018958)2.88627869
130negative regulation of metanephros development (GO:0072217)2.85063258
131mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)2.81808484
132positive regulation of icosanoid secretion (GO:0032305)2.81327859
133negative regulation of hormone biosynthetic process (GO:0032353)2.79610056
134fat-soluble vitamin biosynthetic process (GO:0042362)2.78397872
135reflex (GO:0060004)2.78089337
136vitamin biosynthetic process (GO:0009110)2.77851011
137water-soluble vitamin biosynthetic process (GO:0042364)2.77304149
138xenobiotic catabolic process (GO:0042178)2.75657008
139phenol-containing compound catabolic process (GO:0019336)2.75426957
140negative regulation of hormone metabolic process (GO:0032351)2.74670213
141regulation of guanylate cyclase activity (GO:0031282)2.72910072
142response to pheromone (GO:0019236)2.71077869
143negative regulation of mesenchymal cell apoptotic process (GO:2001054)2.71003538
144cilium or flagellum-dependent cell motility (GO:0001539)2.70662421
145behavioral response to nicotine (GO:0035095)2.68421366
146carnitine metabolic process (GO:0009437)2.67378045
147response to nitrosative stress (GO:0051409)2.66034777
148positive regulation of cellular amine metabolic process (GO:0033240)2.64829804
149* hormone metabolic process (GO:0042445)2.61915514
150xenobiotic metabolic process (GO:0006805)2.54846115
151angiotensin maturation (GO:0002003)2.54160827
152dopamine transport (GO:0015872)2.49213453
153hydrogen peroxide catabolic process (GO:0042744)2.48400266
154intestinal absorption (GO:0050892)2.47657541
155ethanol metabolic process (GO:0006067)2.42464684
156transepithelial transport (GO:0070633)2.42441020
157arginine catabolic process (GO:0006527)2.42208024
158methionine biosynthetic process (GO:0009086)2.41295229
159positive regulation of guanylate cyclase activity (GO:0031284)2.40616859
1603-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)2.40041279
161purine ribonucleoside bisphosphate metabolic process (GO:0034035)2.40041279
162drug transport (GO:0015893)2.38814948

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1RXR_22158963_ChIP-Seq_LIVER_Mouse8.17141530
2* PPARA_22158963_ChIP-Seq_LIVER_Mouse7.02152602
3EGR1_23403033_ChIP-Seq_LIVER_Mouse6.54400444
4LXR_22158963_ChIP-Seq_LIVER_Mouse6.33424780
5FOXO1_23066095_ChIP-Seq_LIVER_Mouse5.05133681
6PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.98891116
7CEBPA_23403033_ChIP-Seq_LIVER_Mouse4.73400415
8NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.99635844
9* CEBPB_23403033_ChIP-Seq_LIVER_Mouse3.62720811
10GLI1_17442700_ChIP-ChIP_MESCs_Mouse3.10796384
11GBX2_23144817_ChIP-Seq_PC3_Human3.07794193
12VDR_22108803_ChIP-Seq_LS180_Human2.54978582
13ZNF274_21170338_ChIP-Seq_K562_Hela2.50874381
14GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.34873770
15ZFP57_27257070_Chip-Seq_ESCs_Mouse2.30508644
16POU3F2_20337985_ChIP-ChIP_501MEL_Human2.26245042
17IGF1R_20145208_ChIP-Seq_DFB_Human2.21507269
18EZH2_22144423_ChIP-Seq_EOC_Human2.17351263
19TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.04078181
20AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human2.03867132
21TCF7L2_21901280_ChIP-Seq_H4IIE_Rat2.02024810
22ESR1_17901129_ChIP-ChIP_LIVER_Mouse11.5110832
23P300_19829295_ChIP-Seq_ESCs_Human1.98387943
24HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.96209823
25ER_23166858_ChIP-Seq_MCF-7_Human1.94278972
26PIAS1_25552417_ChIP-Seq_VCAP_Human1.90492466
27CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.89219704
28CTBP2_25329375_ChIP-Seq_LNCAP_Human1.80056347
29CTBP1_25329375_ChIP-Seq_LNCAP_Human1.79834016
30SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.78753663
31CLOCK_20551151_ChIP-Seq_293T_Human1.78698051
32STAT3_23295773_ChIP-Seq_U87_Human1.66792007
33FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.63541809
34FOXA2_19822575_ChIP-Seq_HepG2_Human1.63413583
35* FUS_26573619_Chip-Seq_HEK293_Human1.62543282
36AR_25329375_ChIP-Seq_VCAP_Human1.62424469
37* NR3C1_21868756_ChIP-Seq_MCF10A_Human1.62359699
38FLI1_27457419_Chip-Seq_LIVER_Mouse1.61903555
39SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.56589991
40* SMAD4_21799915_ChIP-Seq_A2780_Human1.53965954
41UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.53098100
42TCF4_23295773_ChIP-Seq_U87_Human1.50975017
43IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.50166856
44CBP_20019798_ChIP-Seq_JUKART_Human1.50166856
45SMAD3_21741376_ChIP-Seq_EPCs_Human1.50097540
46PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.49754952
47MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.49329727
48CDX2_22108803_ChIP-Seq_LS180_Human1.48543908
49TCF4_22108803_ChIP-Seq_LS180_Human1.46936874
50CDX2_19796622_ChIP-Seq_MESCs_Mouse1.44649411
51EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.43746278
52EWS_26573619_Chip-Seq_HEK293_Human1.43665586
53GATA1_22025678_ChIP-Seq_K562_Human1.41591701
54IRF1_19129219_ChIP-ChIP_H3396_Human1.40613147
55THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.38369923
56* HNF4A_19822575_ChIP-Seq_HepG2_Human1.38263334
57SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.37181154
58EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.36301039
59STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.32339867
60PCGF2_27294783_Chip-Seq_ESCs_Mouse1.30713799
61OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.29502587
62SOX2_19829295_ChIP-Seq_ESCs_Human1.28883768
63NANOG_19829295_ChIP-Seq_ESCs_Human1.28883768
64HTT_18923047_ChIP-ChIP_STHdh_Human1.28027179
65TOP2B_26459242_ChIP-Seq_MCF-7_Human1.26440338
66FOXA1_21572438_ChIP-Seq_LNCaP_Human1.25729888
67KLF5_20875108_ChIP-Seq_MESCs_Mouse1.25487368
68TP53_16413492_ChIP-PET_HCT116_Human1.25074893
69SMAD4_21741376_ChIP-Seq_EPCs_Human1.23609995
70GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.22565932
71* RUNX2_22187159_ChIP-Seq_PCA_Human1.21214298
72RARG_19884340_ChIP-ChIP_MEFs_Mouse1.21033225
73SOX2_27498859_Chip-Seq_STOMACH_Mouse1.20234834
74SMAD3_21741376_ChIP-Seq_HESCs_Human1.19617405
75ESR2_21235772_ChIP-Seq_MCF-7_Human1.17191820
76TP53_22573176_ChIP-Seq_HFKS_Human1.17152241
77* PRDM14_20953172_ChIP-Seq_ESCs_Human1.15231284
78BMI1_23680149_ChIP-Seq_NPCS_Mouse1.14735105
79PCGF2_27294783_Chip-Seq_NPCs_Mouse1.14341178
80* EZH2_27294783_Chip-Seq_NPCs_Mouse1.13677679
81RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.13423606
82ESR1_15608294_ChIP-ChIP_MCF-7_Human1.12672161
83SUZ12_27294783_Chip-Seq_NPCs_Mouse1.12261093
84TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.12033992
85POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.11412211
86TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.11412211
87FOXA1_25329375_ChIP-Seq_VCAP_Human1.10497448
88FOXA1_27270436_Chip-Seq_PROSTATE_Human1.10497448
89NFE2_27457419_Chip-Seq_LIVER_Mouse1.09756591
90RXRA_24833708_ChIP-Seq_LIVER_Mouse1.08520128
91MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.08484627
92P53_22387025_ChIP-Seq_ESCs_Mouse1.08346464
93NCOR_22424771_ChIP-Seq_293T_Human1.07081170
94* CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.06545867
95TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.05889649
96TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.05354642
97EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.04743790
98NANOG_18555785_Chip-Seq_ESCs_Mouse1.04174291
99AR_21572438_ChIP-Seq_LNCaP_Human1.03783348
100DROSHA_22980978_ChIP-Seq_HELA_Human1.03449001
101E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.02857860
102* FLI1_21867929_ChIP-Seq_TH2_Mouse1.02494168
103CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.02416964
104* CRX_20693478_ChIP-Seq_RETINA_Mouse1.02199823
105RXR_22108803_ChIP-Seq_LS180_Human1.01982870
106ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.01833765
107SALL1_21062744_ChIP-ChIP_HESCs_Human1.00592316
108PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.00315870
109GATA4_25053715_ChIP-Seq_YYC3_Human0.99964395
110ETV2_25802403_ChIP-Seq_MESCs_Mouse0.99574188
111HOXB7_26014856_ChIP-Seq_BT474_Human0.99217086
112SMAD4_21741376_ChIP-Seq_HESCs_Human0.99002362
113STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.97491230
114PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.93784554
115ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.92703226
116IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.89216392
117ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.86214382
118BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.82386392
119ESR1_21235772_ChIP-Seq_MCF-7_Human0.80888242
120SALL4_18804426_ChIP-ChIP_XEN_Mouse0.78113403
121AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.77190686
122Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.76687242
123NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.75801527
124BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.75754621
125NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.73976269
126SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.72922100
127NRF2_20460467_ChIP-Seq_MEFs_Mouse0.72115803
128NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.72115803
129CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.71839764
130RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.71664819
131AUTS2_25519132_ChIP-Seq_293T-REX_Human0.71443184
132ZNF263_19887448_ChIP-Seq_K562_Human0.71273641
133CDX2_20551321_ChIP-Seq_CACO-2_Human0.70030788
134IRF8_22096565_ChIP-ChIP_GC-B_Human0.68001649
135LXR_22292898_ChIP-Seq_THP-1_Human0.67317137
136EGR1_19032775_ChIP-ChIP_M12_Human0.66967049
137KAP1_22055183_ChIP-Seq_ESCs_Mouse0.65872610
138RARA_24833708_ChIP-Seq_LIVER_Mouse0.65860863
139RAD21_21589869_ChIP-Seq_MESCs_Mouse0.65768091
140SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.65609774
141FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.60758044
142ESR1_20079471_ChIP-ChIP_T-47D_Human0.60362321
143AR_20517297_ChIP-Seq_VCAP_Human0.60065990
144RARB_24833708_ChIP-Seq_LIVER_Mouse0.59427372
145ERG_21242973_ChIP-ChIP_JURKAT_Human0.57664245
146SOX2_20726797_ChIP-Seq_SW620_Human0.57117865
147FOXO3_23340844_ChIP-Seq_DLD1_Human0.56820182
148STAT3_1855785_ChIP-Seq_MESCs_Mouse0.55311496
149* CEBPB_22108803_ChIP-Seq_LS180_Human0.55079559
150GATA6_25053715_ChIP-Seq_YYC3_Human0.55015547
151PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.54631588
152FOXA1_25552417_ChIP-Seq_VCAP_Human0.54572777
153PPAR_26484153_Chip-Seq_NCI-H1993_Human0.54394030
154PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.53988566
155FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.50645133
156ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.49336778
157RACK7_27058665_Chip-Seq_MCF-7_Human0.49224390
158MYC_19915707_ChIP-ChIP_AK7_Human0.48912237
159SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.48796302
160P53_21459846_ChIP-Seq_SAOS-2_Human0.48719670
161ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.48127527
162FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.47542412
163PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.47034294
164ESET_19884257_ChIP-Seq_ESCs_Mouse0.46722572
165GATA1_19941826_ChIP-Seq_K562_Human0.45982230
166SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.45782639
167* STAT1_17558387_ChIP-Seq_HELA_Human0.45771911
168TAF2_19829295_ChIP-Seq_ESCs_Human0.45745813
169P63_20808887_ChIP-Seq_KERATINOCYTES_Human0.45587732
170SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.45508979
171GATA3_24758297_ChIP-Seq_MCF-7_Human0.45432387
172CBP_21632823_ChIP-Seq_H3396_Human0.45275097
173GATA1_19941827_ChIP-Seq_MEL_Mouse0.44938457
174GATA2_19941826_ChIP-Seq_K562_Human0.44557844
175MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.43220303
176NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.42672276
177PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.42349204
178TAF15_26573619_Chip-Seq_HEK293_Human0.42315281
179EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.42190981
180BCAT_22108803_ChIP-Seq_LS180_Human0.41745266
181FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.41457589
182TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.41205129
183GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.40581508

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system8.09039687
2MP0005360_urolithiasis7.60077803
3MP0005085_abnormal_gallbladder_physiolo6.18926869
4MP0005365_abnormal_bile_salt5.98207593
5MP0008875_abnormal_xenobiotic_pharmacok5.14556447
6MP0003806_abnormal_nucleotide_metabolis4.07216560
7MP0003252_abnormal_bile_duct3.77841839
8MP0001501_abnormal_sleep_pattern3.65340019
9MP0010329_abnormal_lipoprotein_level3.40623713
10MP0009840_abnormal_foam_cell3.11956334
11MP0005083_abnormal_biliary_tract2.92697685
12MP0005332_abnormal_amino_acid2.87572983
13MP0003195_calcinosis2.85193173
14MP0001666_abnormal_nutrient_absorption2.74895926
15MP0004885_abnormal_endolymph2.40641230
16MP0003191_abnormal_cellular_cholesterol2.36131459
17MP0004019_abnormal_vitamin_homeostasis2.24868781
18MP0004147_increased_porphyrin_level2.23073578
19MP0001485_abnormal_pinna_reflex2.13777517
20MP0002138_abnormal_hepatobiliary_system2.07237511
21MP0000609_abnormal_liver_physiology2.06605573
22MP0002118_abnormal_lipid_homeostasis2.06113826
23MP0003868_abnormal_feces_composition2.02627776
24MP0005319_abnormal_enzyme/_coenzyme1.84560865
25MP0005584_abnormal_enzyme/coenzyme_acti1.70369321
26MP0004742_abnormal_vestibular_system1.56427140
27MP0003879_abnormal_hair_cell1.56422445
28MP0001764_abnormal_homeostasis1.54469259
29MP0009643_abnormal_urine_homeostasis1.53216498
30MP0005451_abnormal_body_composition1.43116354
31MP0005551_abnormal_eye_electrophysiolog1.40006546
32MP0001986_abnormal_taste_sensitivity1.36658777
33MP0005646_abnormal_pituitary_gland1.35905535
34MP0009697_abnormal_copulation1.35387189
35MP0003186_abnormal_redox_activity1.29151349
36MP0005645_abnormal_hypothalamus_physiol1.28132574
37MP0003011_delayed_dark_adaptation1.25992678
38MP0003656_abnormal_erythrocyte_physiolo1.25803736
39MP0000427_abnormal_hair_cycle1.25398529
40MP0003183_abnormal_peptide_metabolism1.24669054
41MP0001968_abnormal_touch/_nociception1.22332214
42MP0002876_abnormal_thyroid_physiology1.21850336
43MP0003646_muscle_fatigue1.21033223
44MP0004043_abnormal_pH_regulation1.16283486
45MP0008877_abnormal_DNA_methylation1.15052654
46MP0005647_abnormal_sex_gland1.13161829
47MP0005636_abnormal_mineral_homeostasis1.12796563
48MP0000598_abnormal_liver_morphology1.12542494
49MP0005187_abnormal_penis_morphology1.08303785
50MP0003705_abnormal_hypodermis_morpholog1.07758523
51MP0009764_decreased_sensitivity_to1.06795189
52MP0000631_abnormal_neuroendocrine_gland1.06606721
53MP0000681_abnormal_thyroid_gland1.05342314
54MP0008004_abnormal_stomach_pH1.03481238
55MP0001664_abnormal_digestion1.03176050
56MP0000604_amyloidosis1.02761397
57MP0003890_abnormal_embryonic-extraembry1.01023017
58MP0001963_abnormal_hearing_physiology1.00838317
59MP0000026_abnormal_inner_ear0.99125918
60MP0002102_abnormal_ear_morphology0.96210050
61MP0002254_reproductive_system_inflammat0.94462840
62MP0009763_increased_sensitivity_to0.92057495
63MP0009642_abnormal_blood_homeostasis0.90333758
64MP0006036_abnormal_mitochondrial_physio0.88231117
65MP0002272_abnormal_nervous_system0.86831627
66MP0008469_abnormal_protein_level0.85602930
67MP0001756_abnormal_urination0.83812951
68MP0005084_abnormal_gallbladder_morpholo0.83164925
69MP0002736_abnormal_nociception_after0.82884339
70MP0000538_abnormal_urinary_bladder0.81513559
71MP0004484_altered_response_of0.81488779
72MP0005408_hypopigmentation0.80695924
73MP0009745_abnormal_behavioral_response0.80344680
74MP0010368_abnormal_lymphatic_system0.80339161
75MP0003136_yellow_coat_color0.78069551
76MP0002735_abnormal_chemical_nociception0.75777506
77MP0002078_abnormal_glucose_homeostasis0.74163307
78MP0009053_abnormal_anal_canal0.74052230
79MP0009765_abnormal_xenobiotic_induced0.73552746
80MP0002229_neurodegeneration0.71282173
81MP0004924_abnormal_behavior0.71153020
82MP0005386_behavior/neurological_phenoty0.71153020
83MP0005376_homeostasis/metabolism_phenot0.71075492
84MP0005220_abnormal_exocrine_pancreas0.70810733
85MP0002557_abnormal_social/conspecific_i0.70503937
86MP0008995_early_reproductive_senescence0.68489414
87MP0003045_fibrosis0.68282602
88MP0002909_abnormal_adrenal_gland0.68062083
89MP0005535_abnormal_body_temperature0.67989071
90MP0005174_abnormal_tail_pigmentation0.67905678
91MP0001663_abnormal_digestive_system0.66547677
92MP0003329_amyloid_beta_deposits0.66530740
93MP0005670_abnormal_white_adipose0.66291808
94MP0004130_abnormal_muscle_cell0.65882887
95MP0008775_abnormal_heart_ventricle0.65120638
96MP0000372_irregular_coat_pigmentation0.64942598
97MP0000569_abnormal_digit_pigmentation0.64666680
98MP0003787_abnormal_imprinting0.64392620
99MP0003690_abnormal_glial_cell0.64349721
100MP0002136_abnormal_kidney_physiology0.63854247
101MP0005389_reproductive_system_phenotype0.63188576
102MP0000678_abnormal_parathyroid_gland0.63001784
103MP0002971_abnormal_brown_adipose0.62649273
104MP0005253_abnormal_eye_physiology0.62643184
105MP0002638_abnormal_pupillary_reflex0.61821812
106MP0001661_extended_life_span0.61589606
107MP0004133_heterotaxia0.60222882
108MP0005334_abnormal_fat_pad0.60024268
109MP0003638_abnormal_response/metabolism_0.60018498
110MP0010678_abnormal_skin_adnexa0.59083702
111MP0000383_abnormal_hair_follicle0.58610102
112MP0005266_abnormal_metabolism0.57434920
113MP0001486_abnormal_startle_reflex0.57141898
114MP0005310_abnormal_salivary_gland0.56151390
115MP0006035_abnormal_mitochondrial_morpho0.55692434
116MP0003698_abnormal_male_reproductive0.54913856
117MP0000639_abnormal_adrenal_gland0.54292585
118MP0004145_abnormal_muscle_electrophysio0.53912757
119MP0004782_abnormal_surfactant_physiolog0.52633139
120MP0001984_abnormal_olfaction0.52583716
121MP0003075_altered_response_to0.52333284
122MP0001919_abnormal_reproductive_system0.51646263
123MP0003953_abnormal_hormone_level0.49450643
124MP0005448_abnormal_energy_balance0.49288451
125MP0005058_abnormal_lysosome_morphology0.49236997
126MP0010234_abnormal_vibrissa_follicle0.49162824
127MP0005395_other_phenotype0.45768269
128MP0002796_impaired_skin_barrier0.45277842
129MP0005166_decreased_susceptibility_to0.43932167
130MP0008874_decreased_physiological_sensi0.42925073
131MP0005464_abnormal_platelet_physiology0.42143777
132MP0008872_abnormal_physiological_respon0.41156634
133MP0002928_abnormal_bile_duct0.41011789
134MP0008873_increased_physiological_sensi0.40398355
135MP0001765_abnormal_ion_homeostasis0.40208200
136MP0002822_catalepsy0.38799498
137MP0005666_abnormal_adipose_tissue0.37706896
138MP0002168_other_aberrant_phenotype0.36725453
139MP0004264_abnormal_extraembryonic_tissu0.36453004
140MP0003436_decreased_susceptibility_to0.34314375
141MP0002837_dystrophic_cardiac_calcinosis0.34171915
142MP0000230_abnormal_systemic_arterial0.34148190
143MP0003718_maternal_effect0.32965170
144MP0003724_increased_susceptibility_to0.31212896
145MP0005248_abnormal_Harderian_gland0.31019222
146MP0009115_abnormal_fat_cell0.30713448
147MP0006082_CNS_inflammation0.30560636
148MP0002135_abnormal_kidney_morphology0.30280486
149MP0009384_cardiac_valve_regurgitation0.29451158
150MP0000579_abnormal_nail_morphology0.29410133
151MP0000249_abnormal_blood_vessel0.27784121
152MP0009672_abnormal_birth_weight0.27252294
153MP0001845_abnormal_inflammatory_respons0.27211790

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of aromatic amino acid family metabolism (HP:0004338)7.19223560
2Deep venous thrombosis (HP:0002625)7.04513631
3Intrahepatic cholestasis (HP:0001406)7.00047621
4Congenital sensorineural hearing impairment (HP:0008527)6.52324282
5Abnormality of monocarboxylic acid metabolism (HP:0010996)6.51041216
6Prolonged partial thromboplastin time (HP:0003645)6.12233105
7Hypobetalipoproteinemia (HP:0003563)6.10366442
8Xanthomatosis (HP:0000991)6.01484092
9Hyperlipoproteinemia (HP:0010980)5.20422964
10Complement deficiency (HP:0004431)5.02672199
11Hypothermia (HP:0002045)4.99679297
12Hyperammonemia (HP:0001987)4.57789473
13Hypolipoproteinemia (HP:0010981)4.50907062
14Hyperthyroidism (HP:0000836)4.46652972
15Joint hemorrhage (HP:0005261)4.45752982
16Hyperglycinemia (HP:0002154)4.37744884
17Abnormality of glutamine family amino acid metabolism (HP:0010902)4.36548170
18Ketosis (HP:0001946)4.29689654
19Abnormality of the common coagulation pathway (HP:0010990)4.21818273
20Epidermoid cyst (HP:0200040)4.18729293
21Hyperglycinuria (HP:0003108)4.18629187
22* Aplasia/Hypoplasia of the abdominal wall musculature (HP:0010318)4.17989559
23Abnormality of sulfur amino acid metabolism (HP:0004339)4.13853053
24Abnormality of the level of lipoprotein cholesterol (HP:0010979)4.11005021
25Fat malabsorption (HP:0002630)4.05450669
26Abnormality of aspartate family amino acid metabolism (HP:0010899)4.05441258
27Abnormality of glycine metabolism (HP:0010895)4.04559807
28Abnormality of serine family amino acid metabolism (HP:0010894)4.04559807
29Abnormality of methionine metabolism (HP:0010901)3.94568998
30Hypoalphalipoproteinemia (HP:0003233)3.87766071
31Hypoglycemic coma (HP:0001325)3.74731484
32Delayed CNS myelination (HP:0002188)3.67717830
33Abnormality of complement system (HP:0005339)3.62623607
34Abnormality of pyrimidine metabolism (HP:0004353)3.61896872
35Conjugated hyperbilirubinemia (HP:0002908)3.58997937
36Thyroid carcinoma (HP:0002890)3.55895701
37Abnormality of the intrinsic pathway (HP:0010989)3.55823222
38Hypercholesterolemia (HP:0003124)3.41879001
39Abnormality of fatty-acid metabolism (HP:0004359)3.35818938
40Hyperventilation (HP:0002883)3.34893526
41Hyperbilirubinemia (HP:0002904)3.24204227
42Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.22674103
43Ketoacidosis (HP:0001993)3.21894005
44Abnormality of nucleobase metabolism (HP:0010932)3.13069592
45Decreased circulating renin level (HP:0003351)3.12341163
46Pancreatic cysts (HP:0001737)3.10143524
47Steatorrhea (HP:0002570)3.03785773
48Abnormality of serum amino acid levels (HP:0003112)2.94391720
49Abnormality of purine metabolism (HP:0004352)2.88655952
50Hepatocellular carcinoma (HP:0001402)2.85619177
51Metabolic acidosis (HP:0001942)2.84672977
52Gout (HP:0001997)2.84300416
53Congenital stationary night blindness (HP:0007642)2.84199545
54Spontaneous abortion (HP:0005268)2.76740484
55Lethargy (HP:0001254)2.76202637
56True hermaphroditism (HP:0010459)2.74808732
57Vascular calcification (HP:0004934)2.74500153
58Hyperpituitarism (HP:0010514)2.73476948
59Pancreatic fibrosis (HP:0100732)2.70450051
60Myocardial infarction (HP:0001658)2.68479575
61Abnormality of dicarboxylic acid metabolism (HP:0010995)2.63734818
62Dicarboxylic aciduria (HP:0003215)2.63734818
63Systemic lupus erythematosus (HP:0002725)2.62362879
64Hypochromic microcytic anemia (HP:0004840)2.62086155
65Abnormality of the renal cortex (HP:0011035)2.61337470
66Hyperactive renin-angiotensin system (HP:0000841)2.56510222
67Skin nodule (HP:0200036)2.55761164
68Metabolic alkalosis (HP:0200114)2.50836792
69Irritability (HP:0000737)2.49617510
70* Goiter (HP:0000853)2.46404220
71Cardiovascular calcification (HP:0011915)2.43066769
72Abnormality of renin-angiotensin system (HP:0000847)2.42780234
73Attenuation of retinal blood vessels (HP:0007843)2.42611299
74Malnutrition (HP:0004395)2.41741828
75Abnormality of vitamin B metabolism (HP:0004340)2.40323785
76Spastic diplegia (HP:0001264)2.38873481
77* Hypothyroidism (HP:0000821)2.36316122
78Cerebral edema (HP:0002181)2.36309917
79Acanthocytosis (HP:0001927)2.36013914
80Abnormality of cochlea (HP:0000375)2.34820430
81Hypoglycemic seizures (HP:0002173)2.32953631
82Abnormality of the vitamin B12 metabolism (HP:0004341)2.32881353
83Abnormal gallbladder morphology (HP:0012437)2.32644992
84Glomerulonephritis (HP:0000099)2.32609547
85Neonatal onset (HP:0003623)2.32322442
86Abnormality of urine glucose concentration (HP:0011016)2.29015909
87Glycosuria (HP:0003076)2.29015909
88Mitral stenosis (HP:0001718)2.28014090
89Renal cortical cysts (HP:0000803)2.27958282
90Cholelithiasis (HP:0001081)2.27532988
91Abnormality of vitamin metabolism (HP:0100508)2.27401089
92Type II lissencephaly (HP:0007260)2.26416402
93Amyloidosis (HP:0011034)2.25432561
94Abnormal gallbladder physiology (HP:0012438)2.23369008
95Cholecystitis (HP:0001082)2.23369008
96Sensorimotor neuropathy (HP:0007141)2.23035066
97Esophageal varix (HP:0002040)2.21511034
98Abolished electroretinogram (ERG) (HP:0000550)2.21366097
99Generalized aminoaciduria (HP:0002909)2.20046173
100Late onset (HP:0003584)2.19600418
101Hyperaldosteronism (HP:0000859)2.18402783
102Vomiting (HP:0002013)2.17330739
103Alkalosis (HP:0001948)2.16925096
104Fair hair (HP:0002286)2.15957067
105Molar tooth sign on MRI (HP:0002419)2.15916266
106Abnormality of midbrain morphology (HP:0002418)2.15916266
107Pancreatitis (HP:0001733)2.13361529
108Recurrent gram-negative bacterial infections (HP:0005420)2.10510466
109Nephronophthisis (HP:0000090)2.10487314
110Cystic liver disease (HP:0006706)2.10472504
111Hydroxyprolinuria (HP:0003080)2.10312120
112Abnormality of proline metabolism (HP:0010907)2.10312120
113Pigmentary retinal degeneration (HP:0001146)2.09292012
114Medial flaring of the eyebrow (HP:0010747)2.09264024
115Enlarged kidneys (HP:0000105)2.05993575
116Polyuria (HP:0000103)2.05454901
117Rickets (HP:0002748)2.03515145
118Polydipsia (HP:0001959)2.03154745
119Abnormal drinking behavior (HP:0030082)2.03154745
120Chronic hepatic failure (HP:0100626)2.02718186
121Thyroid-stimulating hormone excess (HP:0002925)2.00536419
122Abnormality of the renal medulla (HP:0100957)2.00465218
123Abnormal urine output (HP:0012590)2.00270496
124Menorrhagia (HP:0000132)2.00241294
125Large for gestational age (HP:0001520)1.99784329
126Brushfield spots (HP:0001088)1.99700042
127Thrombophlebitis (HP:0004418)1.97103518
128Delayed epiphyseal ossification (HP:0002663)1.97054522
129Gingival bleeding (HP:0000225)1.96537555
130Proximal tubulopathy (HP:0000114)1.96239047
131Decreased central vision (HP:0007663)1.96237500
132Bile duct proliferation (HP:0001408)1.93476723
133Abnormal biliary tract physiology (HP:0012439)1.93476723
134Opisthotonus (HP:0002179)1.93473012
135Chronic diarrhea (HP:0002028)1.91419533
136Stomach cancer (HP:0012126)1.91377777
137Abnormal hair laboratory examination (HP:0003328)1.91061165
138Hyperuricemia (HP:0002149)1.91018185
139Increased purine levels (HP:0004368)1.91018185
140Chorioretinal atrophy (HP:0000533)1.90617578
141Abnormality of the gallbladder (HP:0005264)1.89114113
142Abnormality of transition element cation homeostasis (HP:0011030)1.88483361
143Hemorrhage of the eye (HP:0011885)1.88432565
144Abnormality of iron homeostasis (HP:0011031)1.88428657
145Hyperinsulinemic hypoglycemia (HP:0000825)1.85666104
146Abnormal cartilage morphology (HP:0002763)1.85116507
147Abnormal enzyme/coenzyme activity (HP:0012379)1.84545785
148Pili torti (HP:0003777)1.84296568
149Nephritis (HP:0000123)1.83730142
150Gaze-evoked nystagmus (HP:0000640)1.83725470
151Abnormality of renal excretion (HP:0011036)1.83223708
152Hypokalemia (HP:0002900)1.82818625
153Abnormality of alanine metabolism (HP:0010916)1.78544077
154Hyperalaninemia (HP:0003348)1.78544077
155Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.78544077
156Morphological abnormality of the inner ear (HP:0011390)1.77255490
157Amelogenesis imperfecta (HP:0000705)1.76107506
158Methylmalonic aciduria (HP:0012120)1.74618600
159Tubular atrophy (HP:0000092)1.73910322
160* Coarse facial features (HP:0000280)1.70264868
161Generalized hypopigmentation of hair (HP:0011358)1.69977465
162Abnormality of potassium homeostasis (HP:0011042)1.69722968
163Hypomagnesemia (HP:0002917)1.64445920
164Abnormality of chloride homeostasis (HP:0011422)1.64411227
165Inability to walk (HP:0002540)1.63832057
166Aplasia/Hypoplasia of the tibia (HP:0005772)1.61056516
167Confusion (HP:0001289)1.60351732

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK7.03068606
2ERN14.38845131
3SIK14.24873459
4FGFR44.21317821
5ACVR1B3.82211104
6ADRBK22.89551365
7CASK2.88873223
8ERBB42.85824025
9TAOK32.75510446
10BMPR1B2.62696885
11INSRR2.51108675
12TRIB32.43360068
13PKN22.28789408
14MST1R2.24123792
15DAPK22.12859285
16MAP4K22.09618087
17NUAK12.09070656
18STK392.05478523
19MAP2K41.98191188
20FRK1.72138333
21PTK61.69829930
22FGFR21.66377884
23PIK3CG1.63831805
24MAPK111.59564558
25FLT31.59434167
26LATS11.56895241
27ZAK1.54595445
28EPHA21.46815759
29TYK21.39299539
30ERBB31.26945747
31TLK11.24946068
32NEK91.23584452
33ABL21.22988109
34KDR1.22308580
35EPHB11.21680691
36TNIK1.19344814
37JAK21.18367284
38PRKCE1.16139068
39MAP3K71.11743612
40TBK11.10997851
41MAPK131.09984359
42STK38L1.09586516
43GRK61.08211964
44MAP3K41.04379115
45BRSK21.02555954
46NLK1.02403055
47MST41.01744554
48PRKAA20.98608015
49TXK0.98551811
50MAP2K30.98181359
51PINK10.98057268
52PRKCZ0.97778110
53RIPK10.97619628
54ADRBK10.95679100
55MET0.94629369
56MAP3K100.90248596
57MAP3K30.89901954
58MAPK40.88133044
59ERBB20.85431125
60JAK10.85196784
61EIF2AK30.85135055
62MAP3K140.80749680
63PTK20.79974067
64NTRK30.78066827
65MAP2K60.77694625
66MAP3K110.77280974
67MKNK20.77116871
68CAMK1D0.76702719
69MAPK150.76552608
70TIE10.74864337
71IRAK30.74119504
72PRKACG0.73988027
73MAPKAPK30.73685642
74TEC0.73479733
75RET0.71351212
76MAP2K10.69021762
77DYRK1B0.68583932
78KIT0.67999935
79SGK30.66883168
80GSK3A0.66770220
81CSK0.66767678
82WNK40.66303182
83CAMK2G0.64849841
84MAPK120.64386121
85EPHA30.63385725
86PRKAA10.61481528
87PDK40.61296586
88PDK30.61296586
89PDPK10.61134147
90TGFBR20.60855096
91IRAK10.60584032
92MAP2K20.60205322
93AKT30.59169081
94RPS6KA50.58946251
95CAMKK20.58059102
96STK30.56935837
97CDK60.56468543
98PDK20.55907678
99PHKG20.54344365
100PHKG10.54344365
101TRIM280.53081537
102TRPM70.52969100
103EPHA40.52494681
104PRKACA0.52160315
105TGFBR10.52112152
106NEK10.51199034
107NME10.51155988
108MAP3K20.50807589
109CSNK1A10.50715288
110BCR0.50470110
111PAK30.50098337
112PLK20.49678313
113CSNK1G20.48358651
114CAMK2A0.48185702
115PRKCA0.46364460
116PRKCQ0.44803111
117DMPK0.44114926
118IKBKE0.43791049
119FER0.43665939
120MUSK0.42757977
121IGF1R0.41858216
122PRKG10.40739263
123ITK0.40588951
124MYLK0.40358644
125SGK2230.40093048
126SGK4940.40093048
127CHUK0.39527821
128FGFR30.39145713
129PIK3CA0.38616786
130SGK20.38525518
131KSR20.38088065
132CSNK1G10.37950604
133PDK10.37360860
134PKN10.35990813
135EGFR0.35937925
136MAPK70.35427532
137PRKG20.34990565
138MAP2K70.34910234
139GRK10.34065663
140MAP3K50.34011474
141PRKCG0.33527086
142WNK30.32914103
143LRRK20.32910390
144ICK0.32380024
145IKBKB0.32048993
146IRAK20.32026559
147TAOK20.31992561
148CAMK1G0.31886707
149PTK2B0.31051169
150MAP3K10.30256715
151MAP3K130.29870380
152OXSR10.29786638
153MTOR0.29689702
154EPHB20.29455966
155CSNK1G30.27849511
156STK240.27393514
157PNCK0.26490021
158LMTK20.24473695
159PLK40.23696246
160CSNK1A1L0.23670274
161ABL10.23148765
162CSF1R0.22504722
163CSNK1D0.22466730
164CAMK2D0.22373347

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001204.33515579
2Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.42022471
3Nitrogen metabolism_Homo sapiens_hsa009103.41007926
4Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.28970322
5Arginine biosynthesis_Homo sapiens_hsa002203.01912217
6Tryptophan metabolism_Homo sapiens_hsa003802.68173102
7Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.63246699
8Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.62902869
9Complement and coagulation cascades_Homo sapiens_hsa046102.55401919
10Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.50925047
11Fatty acid degradation_Homo sapiens_hsa000712.48509520
12Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.46127159
13Pentose and glucuronate interconversions_Homo sapiens_hsa000402.31638837
14Butanoate metabolism_Homo sapiens_hsa006502.19296761
15Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.18081634
16Peroxisome_Homo sapiens_hsa041462.07563616
17Propanoate metabolism_Homo sapiens_hsa006401.99601224
18Chemical carcinogenesis_Homo sapiens_hsa052041.97875325
19Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.97199109
20Histidine metabolism_Homo sapiens_hsa003401.86013734
21Steroid hormone biosynthesis_Homo sapiens_hsa001401.83327385
22PPAR signaling pathway_Homo sapiens_hsa033201.81036047
23Caffeine metabolism_Homo sapiens_hsa002321.78186657
24Fatty acid metabolism_Homo sapiens_hsa012121.76055737
25Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.69855097
26beta-Alanine metabolism_Homo sapiens_hsa004101.69670939
27Drug metabolism - other enzymes_Homo sapiens_hsa009831.68298249
28Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.68180277
29Tyrosine metabolism_Homo sapiens_hsa003501.64688257
30Bile secretion_Homo sapiens_hsa049761.63922478
31Retinol metabolism_Homo sapiens_hsa008301.62747601
32Sulfur metabolism_Homo sapiens_hsa009201.58620248
33Selenocompound metabolism_Homo sapiens_hsa004501.58130862
34Staphylococcus aureus infection_Homo sapiens_hsa051501.58122267
35Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.57658794
362-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.56906298
37Phenylalanine metabolism_Homo sapiens_hsa003601.48679093
38Pyruvate metabolism_Homo sapiens_hsa006201.45314015
39Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.35596767
40Starch and sucrose metabolism_Homo sapiens_hsa005001.31862151
41Ether lipid metabolism_Homo sapiens_hsa005651.31507197
42Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.30185199
43Fat digestion and absorption_Homo sapiens_hsa049751.28677350
44Fatty acid elongation_Homo sapiens_hsa000621.27638783
45Cysteine and methionine metabolism_Homo sapiens_hsa002701.24128734
46Folate biosynthesis_Homo sapiens_hsa007901.22716400
47Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.17377290
48Biosynthesis of amino acids_Homo sapiens_hsa012301.16352711
49Carbon metabolism_Homo sapiens_hsa012001.15585952
50Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.13431498
51ABC transporters_Homo sapiens_hsa020101.11328519
52Steroid biosynthesis_Homo sapiens_hsa001001.08726353
53Cyanoamino acid metabolism_Homo sapiens_hsa004601.08362129
54Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.03327113
55Vitamin digestion and absorption_Homo sapiens_hsa049770.99988927
56Arginine and proline metabolism_Homo sapiens_hsa003300.99526266
57Maturity onset diabetes of the young_Homo sapiens_hsa049500.98571204
58Phototransduction_Homo sapiens_hsa047440.96226010
59Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.95091218
60Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.88421054
61Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.86698398
62Sulfur relay system_Homo sapiens_hsa041220.86649411
63Vitamin B6 metabolism_Homo sapiens_hsa007500.86087129
64Lysine degradation_Homo sapiens_hsa003100.80008470
65Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.77839011
66Glutathione metabolism_Homo sapiens_hsa004800.77713979
67Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.72735661
68Glycerolipid metabolism_Homo sapiens_hsa005610.70917880
69Sphingolipid metabolism_Homo sapiens_hsa006000.68280380
70Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.66562699
71Intestinal immune network for IgA production_Homo sapiens_hsa046720.64655387
72Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.64260204
73Gastric acid secretion_Homo sapiens_hsa049710.63727984
74Pentose phosphate pathway_Homo sapiens_hsa000300.56216884
75Asthma_Homo sapiens_hsa053100.55215995
76One carbon pool by folate_Homo sapiens_hsa006700.54994063
77Serotonergic synapse_Homo sapiens_hsa047260.54808266
78Taste transduction_Homo sapiens_hsa047420.48937209
79Nicotine addiction_Homo sapiens_hsa050330.47554205
80Autoimmune thyroid disease_Homo sapiens_hsa053200.45903947
81Metabolic pathways_Homo sapiens_hsa011000.45449380
82Fatty acid biosynthesis_Homo sapiens_hsa000610.45164526
83Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.42738097
84Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.42245814
85Insulin secretion_Homo sapiens_hsa049110.36721577
86Protein export_Homo sapiens_hsa030600.34481304
87alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.33005113
88Prion diseases_Homo sapiens_hsa050200.31391349
89Pancreatic secretion_Homo sapiens_hsa049720.29804360
90Linoleic acid metabolism_Homo sapiens_hsa005910.29531312
91Galactose metabolism_Homo sapiens_hsa000520.28168479
92* Thyroid hormone synthesis_Homo sapiens_hsa049180.27871511
93Fructose and mannose metabolism_Homo sapiens_hsa000510.27025676
94Allograft rejection_Homo sapiens_hsa053300.26346511
95Olfactory transduction_Homo sapiens_hsa047400.24528858
96Circadian rhythm_Homo sapiens_hsa047100.24402132
97Salivary secretion_Homo sapiens_hsa049700.23591131
98Insulin resistance_Homo sapiens_hsa049310.23043747
99Type I diabetes mellitus_Homo sapiens_hsa049400.22719517
100Graft-versus-host disease_Homo sapiens_hsa053320.19921352
101Adipocytokine signaling pathway_Homo sapiens_hsa049200.19221350
102Cocaine addiction_Homo sapiens_hsa050300.17869708
103Morphine addiction_Homo sapiens_hsa050320.15656227
104Glycerophospholipid metabolism_Homo sapiens_hsa005640.14451445
105Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.14288075
106Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.14136096
107Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.12544705
108Circadian entrainment_Homo sapiens_hsa047130.10892213
109Glucagon signaling pathway_Homo sapiens_hsa049220.09692418
110Glycosaminoglycan degradation_Homo sapiens_hsa005310.07224137
111AMPK signaling pathway_Homo sapiens_hsa041520.00060102
112Regulation of autophagy_Homo sapiens_hsa04140-0.1968142
113Amoebiasis_Homo sapiens_hsa05146-0.1820236
114Hepatitis C_Homo sapiens_hsa05160-0.1785704
115Bladder cancer_Homo sapiens_hsa05219-0.1627318
116Lysosome_Homo sapiens_hsa04142-0.1612124
117Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604-0.1510675
118Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534-0.1405792
119Ovarian steroidogenesis_Homo sapiens_hsa04913-0.1266004
120Central carbon metabolism in cancer_Homo sapiens_hsa05230-0.1196689
121Arachidonic acid metabolism_Homo sapiens_hsa00590-0.1155912
122Protein digestion and absorption_Homo sapiens_hsa04974-0.1142556
123Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141-0.1136567
124Renin-angiotensin system_Homo sapiens_hsa04614-0.1031922
125Insulin signaling pathway_Homo sapiens_hsa04910-0.0932570
126Carbohydrate digestion and absorption_Homo sapiens_hsa04973-0.0869857
127Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520-0.0721648
128Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932-0.0328432
129Mineral absorption_Homo sapiens_hsa04978-0.0007687

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