IZUMO1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The sperm-specific protein Izumo, named for a Japanese shrine dedicated to marriage, is essential for sperm-egg plasma membrane binding and fusion (Inoue et al., 2005 [PubMed 15759005]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1binding of sperm to zona pellucida (GO:0007339)9.98654747
2axonemal dynein complex assembly (GO:0070286)9.92285603
3epithelial cilium movement (GO:0003351)9.50114260
4spermatid development (GO:0007286)8.88149640
5cilium movement (GO:0003341)7.95936790
6epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)7.75331965
7* single fertilization (GO:0007338)7.59670599
8regulation of cilium movement (GO:0003352)7.54840350
9piRNA metabolic process (GO:0034587)7.31113932
10male meiosis (GO:0007140)7.17866779
11sperm capacitation (GO:0048240)6.99357624
12response to pheromone (GO:0019236)6.85202483
13synaptonemal complex organization (GO:0070193)6.28345313
14* fertilization (GO:0009566)6.17408943
15synaptonemal complex assembly (GO:0007130)6.17369622
16microtubule depolymerization (GO:0007019)6.07247081
17spermatogenesis (GO:0007283)5.68093465
18male gamete generation (GO:0048232)5.66114446
19organic cation transport (GO:0015695)5.54097137
20gamete generation (GO:0007276)5.21041307
21negative regulation of inclusion body assembly (GO:0090084)5.00224957
22calcium ion-dependent exocytosis (GO:0017156)4.98233293
23* cellular process involved in reproduction in multicellular organism (GO:0022412)4.97713315
24* cell recognition (GO:0008037)4.97620562
25germ cell development (GO:0007281)4.91730123
26ventricular system development (GO:0021591)4.88643872
27male meiosis I (GO:0007141)4.83918205
28behavioral response to nicotine (GO:0035095)4.72672266
29DNA methylation involved in gamete generation (GO:0043046)4.63453364
30regulation of inclusion body assembly (GO:0090083)4.63310188
31chromosome organization involved in meiosis (GO:0070192)4.54385377
32spermatid nucleus differentiation (GO:0007289)4.51994662
33cellular ketone body metabolic process (GO:0046950)4.48080210
34centriole assembly (GO:0098534)4.34355416
35meiotic nuclear division (GO:0007126)4.33781177
36regulation of microtubule-based movement (GO:0060632)4.22082988
37centriole replication (GO:0007099)4.13931579
38multicellular organismal reproductive process (GO:0048609)4.11974278
39fucose catabolic process (GO:0019317)4.10731205
40L-fucose metabolic process (GO:0042354)4.10731205
41L-fucose catabolic process (GO:0042355)4.10731205
42seminiferous tubule development (GO:0072520)4.04094794
43ketone body metabolic process (GO:1902224)4.03997109
44glycerol ether metabolic process (GO:0006662)3.96994695
45microtubule severing (GO:0051013)3.94324132
46monoubiquitinated protein deubiquitination (GO:0035520)3.90877652
47rRNA methylation (GO:0031167)3.85087236
48meiosis I (GO:0007127)3.81737833
49left/right pattern formation (GO:0060972)3.73079274
50rRNA modification (GO:0000154)3.66818416
51detection of light stimulus involved in sensory perception (GO:0050962)3.64790198
52detection of light stimulus involved in visual perception (GO:0050908)3.64790198
53ether metabolic process (GO:0018904)3.64287947
54chaperone-mediated protein complex assembly (GO:0051131)3.59654227
55sexual reproduction (GO:0019953)3.54785390
56protein K11-linked deubiquitination (GO:0035871)3.45338401
57meiotic cell cycle (GO:0051321)3.41011098
58DNA deamination (GO:0045006)3.39009439
59chromosome condensation (GO:0030261)3.34792418
60detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.32432408
61multicellular organismal development (GO:0007275)3.32352057
62establishment of protein localization to Golgi (GO:0072600)3.26932092
63DNA packaging (GO:0006323)3.20221841
64phosphatidylethanolamine biosynthetic process (GO:0006646)3.18951976
65alditol metabolic process (GO:0019400)3.15718776
66phosphatidylethanolamine metabolic process (GO:0046337)3.15243608
67genitalia morphogenesis (GO:0035112)3.15223370
68amino-acid betaine transport (GO:0015838)3.13459188
69carnitine transport (GO:0015879)3.13459188
70microtubule polymerization or depolymerization (GO:0031109)3.12000556
71protein localization to cilium (GO:0061512)3.08200706
72protein targeting to Golgi (GO:0000042)3.03418102
73tryptophan catabolic process (GO:0006569)3.01477189
74indole-containing compound catabolic process (GO:0042436)3.01477189
75indolalkylamine catabolic process (GO:0046218)3.01477189
76carnitine transmembrane transport (GO:1902603)3.00646254
77indolalkylamine metabolic process (GO:0006586)3.00027045
78water-soluble vitamin biosynthetic process (GO:0042364)2.99141987
79kynurenine metabolic process (GO:0070189)2.93230225
80gamma-aminobutyric acid transport (GO:0015812)2.93174899
81synapsis (GO:0007129)2.92154755
82single strand break repair (GO:0000012)2.91333311
83spinal cord motor neuron differentiation (GO:0021522)2.89918834
84protein polyglutamylation (GO:0018095)2.87959157
85regulation of centriole replication (GO:0046599)2.86780047
86negative regulation of telomere maintenance (GO:0032205)2.86193662
87glycerol metabolic process (GO:0006071)2.85810592
88neuronal action potential (GO:0019228)2.85210658
89cilium organization (GO:0044782)2.85080686
90intraciliary transport (GO:0042073)2.84905693
91coenzyme catabolic process (GO:0009109)2.84687625
92RNA destabilization (GO:0050779)2.83017607
93regulation of spindle checkpoint (GO:0090231)2.82962319
94axoneme assembly (GO:0035082)2.82764619
95mitotic sister chromatid cohesion (GO:0007064)2.81842069
96protein-cofactor linkage (GO:0018065)2.81437986
97cilium assembly (GO:0042384)2.78818347
98cellular component assembly involved in morphogenesis (GO:0010927)2.78629391
99preassembly of GPI anchor in ER membrane (GO:0016254)2.75665516
100photoreceptor cell maintenance (GO:0045494)2.74718202
101sulfation (GO:0051923)2.71954101
102cAMP catabolic process (GO:0006198)2.71700908
103microtubule-based movement (GO:0007018)2.70401930
104rhodopsin mediated signaling pathway (GO:0016056)2.69378891
105detection of chemical stimulus involved in sensory perception of smell (GO:0050911)2.67956875
106protein localization to Golgi apparatus (GO:0034067)2.66958630
107amine catabolic process (GO:0009310)2.66515271
108cellular biogenic amine catabolic process (GO:0042402)2.66515271
109nucleus organization (GO:0006997)2.65972221
110sister chromatid cohesion (GO:0007062)2.65464981
111gene silencing by RNA (GO:0031047)2.65034697
112meiotic cell cycle process (GO:1903046)2.64980248
113cilium morphogenesis (GO:0060271)2.63472758
114maturation of 5.8S rRNA (GO:0000460)2.61703119
115regulation of rhodopsin mediated signaling pathway (GO:0022400)2.61212582
116nuclear pore complex assembly (GO:0051292)2.61200191
117polyol catabolic process (GO:0046174)2.59791580
118protein complex biogenesis (GO:0070271)2.58798916
119retrograde transport, vesicle recycling within Golgi (GO:0000301)2.58628393
120positive regulation of macrophage activation (GO:0043032)2.57543030
121tryptophan metabolic process (GO:0006568)2.56378751
122regulation of action potential (GO:0098900)2.55793366
123lactate metabolic process (GO:0006089)2.55222902
124primary amino compound metabolic process (GO:1901160)2.53611802
125NAD biosynthetic process (GO:0009435)2.52903452
126membrane depolarization during action potential (GO:0086010)2.52207047
127positive regulation of action potential (GO:0045760)2.51352054
128auditory receptor cell stereocilium organization (GO:0060088)2.50836374
129postsynaptic membrane organization (GO:0001941)2.50826563
130G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.50782500
131nucleoside diphosphate phosphorylation (GO:0006165)2.50557287
132startle response (GO:0001964)2.48411053
133mitochondrial respiratory chain complex assembly (GO:0033108)2.47824741
134cornea development in camera-type eye (GO:0061303)2.47492566
135interferon-gamma secretion (GO:0072643)2.47129813
136regulation of meiosis I (GO:0060631)2.46777115
137cytochrome complex assembly (GO:0017004)2.46683522
138regulation of nuclear cell cycle DNA replication (GO:0033262)2.46412645
139platelet dense granule organization (GO:0060155)2.45810721
140photoreceptor cell development (GO:0042461)2.45121874
141peptidyl-threonine dephosphorylation (GO:0035970)2.39870270
142glycolytic process (GO:0006096)2.35057028
143GTP biosynthetic process (GO:0006183)2.32586260
144quaternary ammonium group transport (GO:0015697)2.30554969
145regulation of podosome assembly (GO:0071801)2.29228717
146macroautophagy (GO:0016236)2.28863720
147sequestering of actin monomers (GO:0042989)2.28217598
148cell wall macromolecule catabolic process (GO:0016998)16.3629884
149cell wall macromolecule metabolic process (GO:0044036)16.3629884
150* fusion of sperm to egg plasma membrane (GO:0007342)14.7088846
151cilium or flagellum-dependent cell motility (GO:0001539)12.9121373
152* multicellular organism reproduction (GO:0032504)12.3745271
153acrosome assembly (GO:0001675)12.0715527
154sperm motility (GO:0030317)11.8056441
155* sperm-egg recognition (GO:0035036)11.5655477
156* plasma membrane fusion (GO:0045026)10.9164095
157acrosome reaction (GO:0007340)10.5768433
158* cell-cell recognition (GO:0009988)10.4278763
159* reproduction (GO:0000003)10.3376025
160motile cilium assembly (GO:0044458)10.0363587

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse9.65947875
2TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse4.27558608
3BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse3.96011649
4PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.76416656
5FLI1_27457419_Chip-Seq_LIVER_Mouse2.53651068
6GBX2_23144817_ChIP-Seq_PC3_Human2.51948349
7STAT6_21828071_ChIP-Seq_BEAS2B_Human2.45504291
8PCGF2_27294783_Chip-Seq_ESCs_Mouse2.39496375
9VDR_22108803_ChIP-Seq_LS180_Human2.25969634
10KAP1_22055183_ChIP-Seq_ESCs_Mouse2.25599992
11CTBP1_25329375_ChIP-Seq_LNCAP_Human2.21581547
12IGF1R_20145208_ChIP-Seq_DFB_Human2.15024418
13EZH2_22144423_ChIP-Seq_EOC_Human2.12946509
14CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.06537924
15ER_23166858_ChIP-Seq_MCF-7_Human2.04647060
16CBX2_27304074_Chip-Seq_ESCs_Mouse2.03003293
17ZNF274_21170338_ChIP-Seq_K562_Hela2.00817329
18P300_19829295_ChIP-Seq_ESCs_Human2.00762477
19GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.00435478
20POU3F2_20337985_ChIP-ChIP_501MEL_Human1.95916579
21STAT1_17558387_ChIP-Seq_HELA_Human1.95893983
22GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.94329911
23KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.91586610
24TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.91176040
25ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.90079708
26EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.88326869
27SALL1_21062744_ChIP-ChIP_HESCs_Human1.88241518
28* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.80469376
29EWS_26573619_Chip-Seq_HEK293_Human1.78694070
30UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.75720416
31GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse1.70768512
32PCGF2_27294783_Chip-Seq_NPCs_Mouse1.69422344
33NFE2_27457419_Chip-Seq_LIVER_Mouse1.69237084
34ELK4_26923725_Chip-Seq_MESODERM_Mouse1.69158771
35KDM2B_26808549_Chip-Seq_REH_Human1.68048502
36MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.66750442
37FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.66177666
38TAL1_26923725_Chip-Seq_HPCs_Mouse1.64908270
39ZFP57_27257070_Chip-Seq_ESCs_Mouse1.63425433
40WDR5_24793694_ChIP-Seq_LNCAP_Human1.55514108
41ETV2_25802403_ChIP-Seq_MESCs_Mouse1.55451818
42SUZ12_27294783_Chip-Seq_NPCs_Mouse1.55032279
43TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.54735686
44RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.53472575
45GATA3_21867929_ChIP-Seq_CD8_Mouse1.52670475
46HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.52226451
47ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.50986584
48RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.50168377
49BMI1_23680149_ChIP-Seq_NPCS_Mouse1.49469200
50CRX_20693478_ChIP-Seq_RETINA_Mouse1.48795571
51AR_25329375_ChIP-Seq_VCAP_Human1.46137436
52NANOG_19829295_ChIP-Seq_ESCs_Human1.44724774
53SOX2_19829295_ChIP-Seq_ESCs_Human1.44724774
54LUZP1_20508642_ChIP-Seq_ESCs_Mouse1.44246141
55STAT3_23295773_ChIP-Seq_U87_Human1.43711542
56MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.43463192
57IRF1_19129219_ChIP-ChIP_H3396_Human1.43424338
58FLI1_21867929_ChIP-Seq_TH2_Mouse1.41489015
59OCT4_18555785_Chip-Seq_ESCs_Mouse1.40159880
60EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.39901221
61SOX2_22085726_ChIP-Seq_NPCs_Mouse1.39877779
62SMAD4_21799915_ChIP-Seq_A2780_Human1.39458245
63TOP2B_26459242_ChIP-Seq_MCF-7_Human1.38617660
64AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.38353313
65FOXA1_27270436_Chip-Seq_PROSTATE_Human1.38124921
66FOXA1_25329375_ChIP-Seq_VCAP_Human1.38124921
67EZH2_27294783_Chip-Seq_NPCs_Mouse1.37699626
68GATA3_21878914_ChIP-Seq_MCF-7_Human1.37671867
69FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.37568856
70SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.36912095
71MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.35600974
72AUTS2_25519132_ChIP-Seq_293T-REX_Human1.35203072
73TP53_22573176_ChIP-Seq_HFKS_Human1.35172597
74GATA3_21867929_ChIP-Seq_TH1_Mouse1.34869155
75ERA_21632823_ChIP-Seq_H3396_Human1.34636190
76REST_21632747_ChIP-Seq_MESCs_Mouse1.34166394
77CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.34023674
78NANOG_18555785_Chip-Seq_ESCs_Mouse1.34018460
79BCAT_22108803_ChIP-Seq_LS180_Human1.33693107
80GF1_26923725_Chip-Seq_HPCs_Mouse1.33418243
81RUNX2_22187159_ChIP-Seq_PCA_Human1.33390326
82IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.32731043
83CBP_20019798_ChIP-Seq_JUKART_Human1.32731043
84EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.32067601
85NCOR_22424771_ChIP-Seq_293T_Human1.31643888
86GATA1_26923725_Chip-Seq_HPCs_Mouse1.31474658
87KLF5_20875108_ChIP-Seq_MESCs_Mouse1.31310484
88P53_22387025_ChIP-Seq_ESCs_Mouse1.30426003
89TCF4_23295773_ChIP-Seq_U87_Human1.30244118
90AR_21572438_ChIP-Seq_LNCaP_Human1.29926545
91CMYC_18555785_Chip-Seq_ESCs_Mouse1.29570587
92KLF4_18555785_Chip-Seq_ESCs_Mouse1.28741109
93P300_18555785_Chip-Seq_ESCs_Mouse1.27943175
94SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.26920802
95TCF4_22108803_ChIP-Seq_LS180_Human1.26337521
96NR3C1_21868756_ChIP-Seq_MCF10A_Human1.26050658
97MYC_19829295_ChIP-Seq_ESCs_Human1.25563294
98ESRRB_18555785_Chip-Seq_ESCs_Mouse1.25479474
99SMAD4_21741376_ChIP-Seq_EPCs_Human1.25267516
100SMAD3_21741376_ChIP-Seq_EPCs_Human1.23876796
101CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.23406723
102PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.22806376
103GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.22524128
104OCT4_21477851_ChIP-Seq_ESCs_Mouse1.22315356
105* NANOG_20526341_ChIP-Seq_ESCs_Human1.22175998
106NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.22042887
107TAF2_19829295_ChIP-Seq_ESCs_Human1.21799984
108SUZ12_18555785_Chip-Seq_ESCs_Mouse1.20905167
109EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.20893269
110TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.20764687
111RUNX1_26923725_Chip-Seq_HPCs_Mouse1.20474583
112PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.20333947
113SETDB1_19884257_ChIP-Seq_MESCs_Mouse1.20148739
114NFIB_24661679_ChIP-Seq_LUNG_Mouse1.19696637
115* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.18739080
116TAF15_26573619_Chip-Seq_HEK293_Human1.18511372
117HOXB7_26014856_ChIP-Seq_BT474_Human1.17654228
118CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.16547630
119SOX2_18555785_Chip-Seq_ESCs_Mouse1.15336199
120PU1_27457419_Chip-Seq_LIVER_Mouse1.15097548
121* EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.14181675
122PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.14008526
123STAT3_18555785_Chip-Seq_ESCs_Mouse1.13600033
124FOXA1_21572438_ChIP-Seq_LNCaP_Human1.13218141
125CTCF_18555785_Chip-Seq_ESCs_Mouse1.12791840
126OCT4_20526341_ChIP-Seq_ESCs_Human1.12648440
127RUNX1_27457419_Chip-Seq_LIVER_Mouse1.12520624
128PIAS1_25552417_ChIP-Seq_VCAP_Human1.12452467
129ESET_19884257_ChIP-Seq_ESCs_Mouse1.11584015
130EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.11546104
131P53_21459846_ChIP-Seq_SAOS-2_Human1.11503754
132PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.11503725
133* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.10604695
134AR_20517297_ChIP-Seq_VCAP_Human1.09103397
135TDRD3_21172665_ChIP-Seq_MCF-7_Human1.08758274
136PRDM14_20953172_ChIP-Seq_ESCs_Human1.08619240
137FOXH1_21741376_ChIP-Seq_EPCs_Human1.08514360
138RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.08163217
139PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.08138519
140ZFX_18555785_Chip-Seq_ESCs_Mouse1.08051131
141NOTCH1_21737748_ChIP-Seq_TLL_Human1.07827480
142CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.07356388
143SMAD1_18555785_Chip-Seq_ESCs_Mouse1.06847596
144ETV1_20927104_ChIP-Seq_GIST48_Human1.04460581
145MYC_18940864_ChIP-ChIP_HL60_Human1.04237731
146FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.03189590
147SPI1_26923725_Chip-Seq_HPCs_Mouse1.02751641
148E2F1_18555785_Chip-Seq_ESCs_Mouse1.02667123
149RAD21_21589869_ChIP-Seq_MESCs_Mouse1.02439680
150LDB1_21186366_ChIP-Seq_BM-HSCs_Mouse1.01688275
151RNF2_27304074_Chip-Seq_NSC_Mouse1.01339774
152CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.01176854
153NMYC_18555785_Chip-Seq_ESCs_Mouse1.01110435
154RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.00847813
155SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.00825850
156EZH2_27294783_Chip-Seq_ESCs_Mouse0.99872042
157RAC3_21632823_ChIP-Seq_H3396_Human0.99537051
158IRF8_27001747_Chip-Seq_BMDM_Mouse0.99325321
159STAT3_18555785_ChIP-Seq_MESCs_Mouse0.98901037
160IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.98542773
161TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.98400291
162PHF8_20622853_ChIP-Seq_HELA_Human0.98364595
163DROSHA_22980978_ChIP-Seq_HELA_Human0.98020605
164SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.97825357
165TP63_19390658_ChIP-ChIP_HaCaT_Human0.97535753
166CTBP2_25329375_ChIP-Seq_LNCAP_Human0.97090254
167CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.96917200
168PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.95173942
169POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.95106521
170TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.95106521
171GF1B_26923725_Chip-Seq_HPCs_Mouse0.94971733
172RARA_24833708_ChIP-Seq_LIVER_Mouse0.94682768
173FUS_26573619_Chip-Seq_HEK293_Human0.93584975

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1* MP0003698_abnormal_male_reproductive5.64482842
2MP0001929_abnormal_gametogenesis5.29884132
3MP0008877_abnormal_DNA_methylation4.58331228
4MP0002210_abnormal_sex_determination3.46462385
5MP0002653_abnormal_ependyma_morphology3.22136521
6* MP0002161_abnormal_fertility/fecundity2.99617530
7MP0003011_delayed_dark_adaptation2.95830486
8MP0001145_abnormal_male_reproductive2.88182004
9MP0001968_abnormal_touch/_nociception2.77445097
10MP0005551_abnormal_eye_electrophysiolog2.60851358
11MP0003195_calcinosis2.57665596
12MP0000653_abnormal_sex_gland2.53564647
13MP0005670_abnormal_white_adipose2.36759580
14MP0005623_abnormal_meninges_morphology2.33210454
15MP0002736_abnormal_nociception_after2.11710813
16MP0006292_abnormal_olfactory_placode2.04684215
17* MP0005410_abnormal_fertilization14.6601326
18MP0005253_abnormal_eye_physiology1.90126482
19MP0003880_abnormal_central_pattern1.85697143
20MP0004233_abnormal_muscle_weight1.80597251
21MP0009745_abnormal_behavioral_response1.78660960
22MP0002837_dystrophic_cardiac_calcinosis1.76410657
23MP0005646_abnormal_pituitary_gland1.75269530
24MP0006276_abnormal_autonomic_nervous1.71273563
25MP0002638_abnormal_pupillary_reflex1.70180463
26MP0003787_abnormal_imprinting1.67839738
27MP0001486_abnormal_startle_reflex1.67524819
28MP0002272_abnormal_nervous_system1.66906203
29MP0006072_abnormal_retinal_apoptosis1.64207923
30MP0004147_increased_porphyrin_level1.63379547
31MP0001485_abnormal_pinna_reflex1.63253812
32MP0002254_reproductive_system_inflammat1.61319483
33MP0002735_abnormal_chemical_nociception1.60640126
34MP0003718_maternal_effect1.57312315
35MP0008872_abnormal_physiological_respon1.54022181
36MP0004742_abnormal_vestibular_system1.52581368
37MP0008875_abnormal_xenobiotic_pharmacok1.51699694
38MP0004885_abnormal_endolymph1.51347438
39MP0005423_abnormal_somatic_nervous1.50523616
40MP0004142_abnormal_muscle_tone1.43715367
41MP0003136_yellow_coat_color1.40565299
42MP0008058_abnormal_DNA_repair1.38870384
43MP0002733_abnormal_thermal_nociception1.32929910
44MP0001835_abnormal_antigen_presentation1.31411465
45MP0000372_irregular_coat_pigmentation1.29170516
46MP0000427_abnormal_hair_cycle1.28440093
47MP0001501_abnormal_sleep_pattern1.26836571
48MP0005084_abnormal_gallbladder_morpholo1.25362713
49MP0000685_abnormal_immune_system1.24698210
50MP0002572_abnormal_emotion/affect_behav1.24387334
51MP0002160_abnormal_reproductive_system1.24384638
52MP0001970_abnormal_pain_threshold1.24043427
53MP0002557_abnormal_social/conspecific_i1.23249798
54MP0004133_heterotaxia1.19618932
55MP0005379_endocrine/exocrine_gland_phen1.18829282
56MP0000631_abnormal_neuroendocrine_gland1.17349570
57MP0002282_abnormal_trachea_morphology1.16728482
58MP0009785_altered_susceptibility_to1.15251996
59MP0005647_abnormal_sex_gland1.14221190
60MP0002102_abnormal_ear_morphology1.13109365
61MP0002064_seizures1.11571943
62MP0008057_abnormal_DNA_replication1.11177549
63MP0004043_abnormal_pH_regulation1.11076158
64MP0001905_abnormal_dopamine_level1.10755722
65MP0003646_muscle_fatigue1.10065864
66MP0009278_abnormal_bone_marrow1.09363307
67MP0002067_abnormal_sensory_capabilities1.09052580
68MP0003137_abnormal_impulse_conducting1.09030901
69MP0004145_abnormal_muscle_electrophysio1.06277622
70MP0002938_white_spotting1.05967967
71MP0010094_abnormal_chromosome_stability1.04501386
72MP0003635_abnormal_synaptic_transmissio1.02404472
73MP0009046_muscle_twitch1.00817130
74MP0002234_abnormal_pharynx_morphology0.99690344
75MP0008995_early_reproductive_senescence0.99471462
76MP0001502_abnormal_circadian_rhythm0.99434637
77MP0002229_neurodegeneration0.99238552
78MP0001873_stomach_inflammation0.98652950
79MP0001963_abnormal_hearing_physiology0.98268467
80MP0004924_abnormal_behavior0.96386957
81MP0005386_behavior/neurological_phenoty0.96386957
82MP0000026_abnormal_inner_ear0.96020520
83MP0008775_abnormal_heart_ventricle0.94033672
84MP0001764_abnormal_homeostasis0.90668181
85MP0002734_abnormal_mechanical_nocicepti0.90210202
86MP0005332_abnormal_amino_acid0.88512767
87MP0004085_abnormal_heartbeat0.87932885
88MP0002752_abnormal_somatic_nervous0.87825852
89MP0005195_abnormal_posterior_eye0.87406498
90MP0002063_abnormal_learning/memory/cond0.85726255
91MP0001765_abnormal_ion_homeostasis0.85683236
92MP0001529_abnormal_vocalization0.85156896
93MP0004215_abnormal_myocardial_fiber0.84740332
94MP0002138_abnormal_hepatobiliary_system0.84153495
95MP0002163_abnormal_gland_morphology0.81898841
96MP0001545_abnormal_hematopoietic_system0.80936731
97MP0005397_hematopoietic_system_phenotyp0.80936731
98MP0010329_abnormal_lipoprotein_level0.78091308
99MP0002148_abnormal_hypersensitivity_rea0.77318979
100MP0005085_abnormal_gallbladder_physiolo0.77315509
101MP0001984_abnormal_olfaction0.76837487
102MP0005671_abnormal_response_to0.76776902
103MP0000230_abnormal_systemic_arterial0.76184896
104MP0008789_abnormal_olfactory_epithelium0.74538257
105MP0005025_abnormal_response_to0.71523544
106MP0005310_abnormal_salivary_gland0.71428681
107MP0002405_respiratory_system_inflammati0.70653324
108MP0004510_myositis0.69871766
109MP0002928_abnormal_bile_duct0.67809807
110MP0003878_abnormal_ear_physiology0.66444153
111MP0005377_hearing/vestibular/ear_phenot0.66444153
112MP0010307_abnormal_tumor_latency0.65866382
113MP0005174_abnormal_tail_pigmentation0.65380653
114MP0001348_abnormal_lacrimal_gland0.63151754
115MP0003950_abnormal_plasma_membrane0.62744756
116MP0004084_abnormal_cardiac_muscle0.60844749
117MP0005389_reproductive_system_phenotype0.60431946
118MP0000569_abnormal_digit_pigmentation0.59751441
119MP0005387_immune_system_phenotype0.58958630
120MP0001790_abnormal_immune_system0.58958630
121MP0008007_abnormal_cellular_replicative0.58783825
122MP0005167_abnormal_blood-brain_barrier0.58272759
123MP0003111_abnormal_nucleus_morphology0.57965396
124MP0004036_abnormal_muscle_relaxation0.56362066
125MP0002876_abnormal_thyroid_physiology0.55048142
126MP0001119_abnormal_female_reproductive0.54125202
127MP0004808_abnormal_hematopoietic_stem0.53253634
128MP0005645_abnormal_hypothalamus_physiol0.52638336
129MP0001853_heart_inflammation0.51580741
130MP0002723_abnormal_immune_serum0.50315219
131MP0009115_abnormal_fat_cell0.50143270
132MP0005636_abnormal_mineral_homeostasis0.49382141
133MP0003786_premature_aging0.48283314
134MP0002971_abnormal_brown_adipose0.46878359
135MP0002419_abnormal_innate_immunity0.46122146
136MP0001293_anophthalmia0.45917502
137MP0003879_abnormal_hair_cell0.45718058
138MP0002452_abnormal_antigen_presenting0.45060877
139MP0006082_CNS_inflammation0.44359933
140MP0006138_congestive_heart_failure0.43835814
141MP0001800_abnormal_humoral_immune0.43833782
142MP0001845_abnormal_inflammatory_respons0.43792388
143MP0008469_abnormal_protein_level0.43545952
144MP0003699_abnormal_female_reproductive0.41779365
145MP0005365_abnormal_bile_salt0.41229155
146MP0003279_aneurysm0.40275670
147MP0001986_abnormal_taste_sensitivity0.39657928
148MP0003890_abnormal_embryonic-extraembry0.38936252
149MP0002693_abnormal_pancreas_physiology0.36485600
150MP0005451_abnormal_body_composition0.35309898
151MP0009764_decreased_sensitivity_to0.34175163
152MP0005666_abnormal_adipose_tissue0.34090700
153MP0001851_eye_inflammation0.34001715
154MP0005000_abnormal_immune_tolerance0.32911899
155MP0001819_abnormal_immune_cell0.32022759
156MP0000343_altered_response_to0.31952014
157MP0002420_abnormal_adaptive_immunity0.31264403
158MP0004947_skin_inflammation0.31201567
159MP0000313_abnormal_cell_death0.31048629
160MP0010352_gastrointestinal_tract_polyps0.30264094
161MP0005319_abnormal_enzyme/_coenzyme0.30114767
162MP0010368_abnormal_lymphatic_system0.29026189
163MP0002277_abnormal_respiratory_mucosa0.28575445
164MP0004019_abnormal_vitamin_homeostasis0.26424854
165MP0003115_abnormal_respiratory_system0.25608121
166MP0000716_abnormal_immune_system0.25605100
167MP0003633_abnormal_nervous_system0.25560615

Predicted human phenotypes

RankGene SetZ-score
1Abnormal respiratory motile cilium morphology (HP:0005938)9.09867789
2Abnormal respiratory epithelium morphology (HP:0012253)9.09867789
3Abnormal respiratory motile cilium physiology (HP:0012261)9.02322106
4Rhinitis (HP:0012384)7.61183115
5Abnormal ciliary motility (HP:0012262)7.51228301
6Chronic bronchitis (HP:0004469)6.84114666
7Nasal polyposis (HP:0100582)6.66249446
8Abnormality of the nasal mucosa (HP:0000433)5.70022813
9Infertility (HP:0000789)5.67781673
10Bronchiectasis (HP:0002110)4.72258492
11Bronchitis (HP:0012387)4.62201313
12Congenital stationary night blindness (HP:0007642)4.33743372
13Attenuation of retinal blood vessels (HP:0007843)4.25045787
14Recurrent sinusitis (HP:0011108)3.99617880
15Pancreatic cysts (HP:0001737)3.93726883
16Abnormal rod and cone electroretinograms (HP:0008323)3.82770228
17Nephronophthisis (HP:0000090)3.75014159
18Abnormal spermatogenesis (HP:0008669)3.52958018
19True hermaphroditism (HP:0010459)3.52055196
20Bony spicule pigmentary retinopathy (HP:0007737)3.44994474
21Male infertility (HP:0003251)3.25165988
22Recurrent bronchitis (HP:0002837)3.14259077
23Recurrent otitis media (HP:0000403)3.13958943
24Medial flaring of the eyebrow (HP:0010747)3.07241350
25Hyperventilation (HP:0002883)3.02345824
26Severe visual impairment (HP:0001141)3.00808342
27Pendular nystagmus (HP:0012043)3.00200617
28Abnormality of the renal medulla (HP:0100957)2.97778456
29Azoospermia (HP:0000027)2.90565112
30Polyuria (HP:0000103)2.80914289
31Decreased central vision (HP:0007663)2.80046108
32Tubulointerstitial nephritis (HP:0001970)2.79649798
33Abolished electroretinogram (ERG) (HP:0000550)2.78231564
34Abnormality of macular pigmentation (HP:0008002)2.67314293
35Impulsivity (HP:0100710)2.62425207
36Type II lissencephaly (HP:0007260)2.59221396
37Tubular atrophy (HP:0000092)2.56975085
38Tongue fasciculations (HP:0001308)2.56910674
39Muscle fibrillation (HP:0010546)2.54821240
40Decreased electroretinogram (ERG) amplitude (HP:0000654)2.49136651
41Absent rod-and cone-mediated responses on ERG (HP:0007688)2.47485931
42Abnormal urine output (HP:0012590)2.45796057
43Chronic sinusitis (HP:0011109)2.40443962
44Chorioretinal atrophy (HP:0000533)2.33922581
45Gonadotropin excess (HP:0000837)2.31536085
46Tubulointerstitial abnormality (HP:0001969)2.28887329
47Progressive cerebellar ataxia (HP:0002073)2.28151083
48Congenital primary aphakia (HP:0007707)2.26534447
49Abnormality of midbrain morphology (HP:0002418)2.25924547
50Molar tooth sign on MRI (HP:0002419)2.25924547
51Sclerocornea (HP:0000647)2.25020427
52Gait imbalance (HP:0002141)2.23135999
53Gaze-evoked nystagmus (HP:0000640)2.15942545
54Increased corneal curvature (HP:0100692)2.14438886
55Keratoconus (HP:0000563)2.14438886
56Anencephaly (HP:0002323)2.08780694
57Large for gestational age (HP:0001520)2.08169206
58Inability to walk (HP:0002540)2.08147759
59Renal Fanconi syndrome (HP:0001994)2.04784641
60Broad-based gait (HP:0002136)2.00132216
61Respiratory insufficiency due to defective ciliary clearance (HP:0200073)13.0493044
62Absent/shortened dynein arms (HP:0200106)12.6158703
63Dynein arm defect of respiratory motile cilia (HP:0012255)12.6158703
64Decreased circulating renin level (HP:0003351)1.98259136
65Cerebellar dysplasia (HP:0007033)1.95839303
66Type 2 muscle fiber atrophy (HP:0003554)1.94876995
67Lissencephaly (HP:0001339)1.93950927
68Nephrogenic diabetes insipidus (HP:0009806)1.90275801
69Hypoplasia of the capital femoral epiphysis (HP:0003090)1.89392158
70Renal cortical cysts (HP:0000803)1.88917974
71Abnormality of alanine metabolism (HP:0010916)1.88517486
72Hyperalaninemia (HP:0003348)1.88517486
73Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.88517486
74Congenital hepatic fibrosis (HP:0002612)1.87943833
75Optic disc pallor (HP:0000543)1.86882114
76Abnormality of the neuromuscular junction (HP:0003398)1.86756805
77Fatigable weakness (HP:0003473)1.86756805
78Hypomagnesemia (HP:0002917)1.85852533
79Easy fatigability (HP:0003388)1.84861597
80Tubulointerstitial fibrosis (HP:0005576)1.83024328
81Protruding tongue (HP:0010808)1.82612872
82Poor coordination (HP:0002370)1.80845111
83Febrile seizures (HP:0002373)1.80774841
84Male pseudohermaphroditism (HP:0000037)1.80102675
85Genetic anticipation (HP:0003743)1.79140726
86Aplasia/Hypoplasia of the fovea (HP:0008060)1.75937742
87Hypoplasia of the fovea (HP:0007750)1.75937742
88Hemiparesis (HP:0001269)1.72822858
89Microglossia (HP:0000171)1.72422303
90Aplasia/Hypoplasia of the spleen (HP:0010451)1.72032077
91Hyperglycinuria (HP:0003108)1.71870023
92Abnormality of the renal cortex (HP:0011035)1.71851027
93Increased CSF lactate (HP:0002490)1.71502472
94Aplasia/Hypoplasia of the tibia (HP:0005772)1.71212451
95Abnormality of urine glucose concentration (HP:0011016)1.70124406
96Glycosuria (HP:0003076)1.70124406
97Weak cry (HP:0001612)1.69948555
98Methylmalonic acidemia (HP:0002912)1.69900044
99Pachygyria (HP:0001302)1.69206314
100Mitochondrial inheritance (HP:0001427)1.68369027
101Abnormality of the labia minora (HP:0012880)1.68013701
102Congenital sensorineural hearing impairment (HP:0008527)1.67873922
103Progressive inability to walk (HP:0002505)1.67488084
104Photophobia (HP:0000613)1.67366587
105Chronic otitis media (HP:0000389)1.67290964
106Retinal dysplasia (HP:0007973)1.66984998
107Rib fusion (HP:0000902)1.66743379
108Type II diabetes mellitus (HP:0005978)1.66481292
109Abnormality of renal resorption (HP:0011038)1.65926540
110Stomach cancer (HP:0012126)1.65426466
111Intestinal atresia (HP:0011100)1.63967140
112Supernumerary spleens (HP:0009799)1.63873837
113Lipid accumulation in hepatocytes (HP:0006561)1.63192584
114Acute necrotizing encephalopathy (HP:0006965)1.62666289
115Furrowed tongue (HP:0000221)1.62046487
116Muscle fiber atrophy (HP:0100295)1.60688163
117Postaxial foot polydactyly (HP:0001830)1.59095694
118Facial cleft (HP:0002006)1.58147534
119Genital tract atresia (HP:0001827)1.56465246
120Vaginal atresia (HP:0000148)1.56400656
121Bile duct proliferation (HP:0001408)1.55943802
122Abnormal biliary tract physiology (HP:0012439)1.55943802
123Stage 5 chronic kidney disease (HP:0003774)1.55185564
124Aplasia/Hypoplasia of the lens (HP:0008063)1.52877772
125Heterotopia (HP:0002282)1.51851644
126Renal dysplasia (HP:0000110)1.48704977
127Chronic hepatic failure (HP:0100626)1.44116817
128Postaxial hand polydactyly (HP:0001162)1.42747329
129Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.41606587
130Absent epiphyses (HP:0010577)1.41606587
131Abnormality of saccadic eye movements (HP:0000570)1.39103973
132Optic nerve hypoplasia (HP:0000609)1.38567442
133Spastic tetraparesis (HP:0001285)1.38033683
134J-shaped sella turcica (HP:0002680)1.37660408
135Fibular hypoplasia (HP:0003038)1.36995950
136Absent frontal sinuses (HP:0002688)1.36283948
137Pancreatic fibrosis (HP:0100732)1.35732534
138Polydipsia (HP:0001959)1.35324926
139Abnormal drinking behavior (HP:0030082)1.35324926
140Renovascular hypertension (HP:0100817)1.35311785
141Abnormality of renal excretion (HP:0011036)1.33414778
142Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.33389894
143High pitched voice (HP:0001620)1.32576593
144Ectopic kidney (HP:0000086)1.32219520
145Abnormality of ocular smooth pursuit (HP:0000617)1.30496252
146Nonprogressive disorder (HP:0003680)1.30430312
147Abnormality of permanent molar morphology (HP:0011071)1.29776396
148Abnormality of the dental root (HP:0006486)1.29776396
149Taurodontia (HP:0000679)1.29776396
150Short ribs (HP:0000773)1.29323723
151Aplasia/Hypoplasia of the tongue (HP:0010295)1.29194627
152Deformed sella turcica (HP:0002681)1.25926437
153Hemorrhage of the eye (HP:0011885)1.25218623
154Aplasia/Hypoplasia affecting the fundus (HP:0008057)1.22501991
155Abnormality of molar morphology (HP:0011070)1.21065694
156Abnormality of molar (HP:0011077)1.21065694
157Cystic liver disease (HP:0006706)1.20707681
158Hypoplasia of dental enamel (HP:0006297)1.19335063
159Oculomotor apraxia (HP:0000657)1.18287395
160Polygenic inheritance (HP:0010982)1.15799775
161Generalized muscle weakness (HP:0003324)1.15789350
162Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.13480546
163Abnormality of the dental pulp (HP:0006479)1.13389555
164Optic neuritis (HP:0100653)1.11949563
165Retrobulbar optic neuritis (HP:0100654)1.11949563
166Sloping forehead (HP:0000340)1.11291530

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK38.46387875
2PDK48.46387875
3PDK25.56288385
4FRK5.05946456
5TESK14.81479664
6PRKD34.09425078
7MAP4K23.52197342
8ICK3.13818137
9ZAK3.07555581
10ADRBK22.80080975
11WNK32.41608210
12TLK12.35976663
13PTK2B2.25626071
14NUAK12.22654990
15NEK22.20309240
16WNK42.17572770
17OXSR12.10906611
18STK391.96144854
19MAPK131.76676572
20ACVR1B1.66144198
21MAP3K41.64061118
22CASK1.55131513
23TAOK31.53819028
24PLK41.43983509
25NTRK31.41838564
26PLK21.40960437
27MARK11.33591706
28TNIK1.31283158
29STK38L1.30705407
30DYRK1B1.26839148
31PNCK1.24219478
32DAPK21.21553386
33DYRK21.16339684
34CDK121.16139573
35STK381.15604083
36CDC71.13295915
37LMTK21.10432399
38TXK1.09992921
39MKNK21.09327445
40PHKG21.09162676
41PHKG11.09162676
42PRKCE1.06914007
43PDK11.05396504
44MAP2K61.03149262
45EIF2AK31.02869759
46CCNB11.00643890
47IRAK10.98453532
48MAPKAPK30.95463026
49PAK30.94426265
50ADRBK10.91513878
51TIE10.90732215
52DYRK30.84154258
53MAP2K70.83668961
54CHEK20.83376507
55TRIM280.79963121
56VRK10.77963429
57PRKCI0.75845648
58TTK0.74657977
59TNK20.70915872
60PASK0.70231770
61CDK30.66413302
62MAPK150.65172951
63TBK10.63902855
64WNK10.62507639
65TGFBR20.61041047
66WEE10.60650184
67MAP3K140.59369667
68TYK20.57602312
69PRKCQ0.57420887
70BCKDK0.56208782
71PLK30.55778853
72CHEK10.55657559
73FGFR20.54407688
74MKNK10.54189061
75PDPK10.53646797
76CAMK2A0.53533112
77ATR0.52728607
78PKN10.52640152
79PRKCZ0.52567867
80TYRO30.52453855
81PIK3CA0.52183078
82BRSK20.51537429
83PRKACA0.51343138
84PRKG20.49164570
85ATM0.48099247
86PRKAA20.47615838
87RPS6KA50.47418040
88YES10.46679437
89CAMKK20.46384651
90CSNK1G10.45662894
91CSNK1G20.45073073
92MUSK0.44188959
93STK30.43997323
94STK110.42535564
95CSNK1G30.42455743
96CSNK1A10.41126001
97NLK0.39980298
98PTK60.38626077
99MAP3K100.38453354
100OBSCN0.37670202
101PRKCA0.36884053
102SIK20.36490986
103BMPR20.35665536
104GRK10.35097063
105RIPK10.34473313
106EPHA40.34348855
107TAF10.33920872
108GRK70.33736241
109NEK60.32592644
110RIPK40.32414489
111EEF2K0.31728597
112PINK10.31315469
113CSNK1A1L0.30657042
114BLK0.30639919
115TGFBR10.30459640
116PLK10.30335463
117PAK10.30211209
118CDK190.29882541
119SGK20.29581525
120ITK0.29510861
121CAMK10.29337218
122SGK4940.29331614
123SGK2230.29331614
124PAK40.29241212
125EIF2AK20.28807044
126EGFR0.28569454
127ERBB30.28471992
128BMPR1B0.28335503
129IKBKB0.27880136
130TESK20.27794093
131STK100.26558390
132TEC0.25924327
133CAMK1G0.25165791
134MARK30.23478477
135CSNK2A10.23183915
136ERN10.23135474
137CSNK2A20.21198209
138MTOR0.20569561
139PIM10.19673100
140KIT0.19430668
141PIK3CG0.18532913
142BTK0.17949069
143CDK40.16992946
144INSRR0.16712509
145KDR0.16228135
146CHUK0.16038267
147CSNK1D0.15729845
148TTN0.15517848
149BRSK10.15100950
150EPHB10.14677179
151PRKG10.14157273
152MATK0.13657945
153PRKDC0.12691065
154CDK70.11979419
155PRKCD0.11874256
156MAPKAPK50.11188893
157IKBKE0.11060876
158PRKCG0.10330806
159PRKAA10.10077108
160MAP4K10.09555451
161ZAP700.09125703
162SYK0.08830487
163CDK20.08760600
164GSK3B0.08607330
165AURKB0.08473764
166PRKACG0.08021381
167AKT30.07424522
168RPS6KB10.07294838
169RPS6KA10.07002652

Predicted pathways (KEGG)

RankGene SetZ-score
1Glycolysis / Gluconeogenesis_Homo sapiens_hsa000103.77466446
2Pyruvate metabolism_Homo sapiens_hsa006203.34754232
3Vitamin B6 metabolism_Homo sapiens_hsa007503.31579459
4Fatty acid biosynthesis_Homo sapiens_hsa000613.29252633
5Synthesis and degradation of ketone bodies_Homo sapiens_hsa000723.28597495
6Phototransduction_Homo sapiens_hsa047443.12955436
7Propanoate metabolism_Homo sapiens_hsa006402.99004327
8Basal transcription factors_Homo sapiens_hsa030222.84955679
9Glycosaminoglycan degradation_Homo sapiens_hsa005312.79380924
10Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.70314968
11Selenocompound metabolism_Homo sapiens_hsa004502.65130335
12Pentose phosphate pathway_Homo sapiens_hsa000302.47785549
13Linoleic acid metabolism_Homo sapiens_hsa005912.44021625
14alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.43410856
15Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005122.41801185
16Fanconi anemia pathway_Homo sapiens_hsa034602.41789114
17Butanoate metabolism_Homo sapiens_hsa006502.34589039
18Glucagon signaling pathway_Homo sapiens_hsa049222.27371963
19Nitrogen metabolism_Homo sapiens_hsa009102.16548559
20Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.13176043
21Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.09421906
22Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.09212026
23Olfactory transduction_Homo sapiens_hsa047402.06320433
24Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.94484828
25Nicotine addiction_Homo sapiens_hsa050331.93595513
26Maturity onset diabetes of the young_Homo sapiens_hsa049501.87621832
27Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.84910987
28Oxidative phosphorylation_Homo sapiens_hsa001901.81055239
29PPAR signaling pathway_Homo sapiens_hsa033201.80083210
30Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.78819117
31Glycerolipid metabolism_Homo sapiens_hsa005611.78201999
32Caffeine metabolism_Homo sapiens_hsa002321.70614724
33Intestinal immune network for IgA production_Homo sapiens_hsa046721.67653416
34Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.62168562
35Antigen processing and presentation_Homo sapiens_hsa046121.59060828
36Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.57847402
37Carbohydrate digestion and absorption_Homo sapiens_hsa049731.55984900
38Fructose and mannose metabolism_Homo sapiens_hsa000511.55776815
39Tryptophan metabolism_Homo sapiens_hsa003801.50709208
40Legionellosis_Homo sapiens_hsa051341.49373956
41Huntingtons disease_Homo sapiens_hsa050161.42384317
42Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.41038299
43Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.39430250
44Parkinsons disease_Homo sapiens_hsa050121.36321050
45Cysteine and methionine metabolism_Homo sapiens_hsa002701.33918041
46RNA polymerase_Homo sapiens_hsa030201.32971838
47Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.32550045
48Morphine addiction_Homo sapiens_hsa050321.30187560
49Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.28221393
50Oocyte meiosis_Homo sapiens_hsa041141.27436640
51Protein export_Homo sapiens_hsa030601.24500592
52Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.22874963
53Carbon metabolism_Homo sapiens_hsa012001.22560356
54Dorso-ventral axis formation_Homo sapiens_hsa043201.21362731
55Homologous recombination_Homo sapiens_hsa034401.17345197
56Retinol metabolism_Homo sapiens_hsa008301.11318940
57Peroxisome_Homo sapiens_hsa041461.08895814
58RNA transport_Homo sapiens_hsa030131.08529816
59Primary bile acid biosynthesis_Homo sapiens_hsa001201.08421056
60Glycerophospholipid metabolism_Homo sapiens_hsa005641.07573144
61Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.04674572
62Type I diabetes mellitus_Homo sapiens_hsa049401.04355462
63Steroid hormone biosynthesis_Homo sapiens_hsa001401.04149722
64Ether lipid metabolism_Homo sapiens_hsa005651.03980089
65Regulation of autophagy_Homo sapiens_hsa041401.03503321
66Fat digestion and absorption_Homo sapiens_hsa049751.03075962
67RNA degradation_Homo sapiens_hsa030181.02947025
68Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.98593504
69mRNA surveillance pathway_Homo sapiens_hsa030150.98241711
70Asthma_Homo sapiens_hsa053100.97575541
71GABAergic synapse_Homo sapiens_hsa047270.97202771
72Phenylalanine metabolism_Homo sapiens_hsa003600.97181564
73Mineral absorption_Homo sapiens_hsa049780.96461550
74Purine metabolism_Homo sapiens_hsa002300.94938910
75Insulin secretion_Homo sapiens_hsa049110.93676668
76Cardiac muscle contraction_Homo sapiens_hsa042600.93139228
77Circadian entrainment_Homo sapiens_hsa047130.92583072
78Chemical carcinogenesis_Homo sapiens_hsa052040.90778980
79Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.88099875
80Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.87588697
81beta-Alanine metabolism_Homo sapiens_hsa004100.87324964
82Fatty acid degradation_Homo sapiens_hsa000710.86445994
83One carbon pool by folate_Homo sapiens_hsa006700.85507017
84Allograft rejection_Homo sapiens_hsa053300.85006226
85Glutathione metabolism_Homo sapiens_hsa004800.84322167
86Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.83050182
87Amphetamine addiction_Homo sapiens_hsa050310.81910892
88Glutamatergic synapse_Homo sapiens_hsa047240.79006907
89Renin-angiotensin system_Homo sapiens_hsa046140.78005305
90Ovarian steroidogenesis_Homo sapiens_hsa049130.77437591
91Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.77177529
92Biosynthesis of amino acids_Homo sapiens_hsa012300.76416891
93Salivary secretion_Homo sapiens_hsa049700.74606131
94Arachidonic acid metabolism_Homo sapiens_hsa005900.74551405
95N-Glycan biosynthesis_Homo sapiens_hsa005100.73986649
96Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.73646128
97Serotonergic synapse_Homo sapiens_hsa047260.72798215
98Sulfur relay system_Homo sapiens_hsa041220.72090872
99Alzheimers disease_Homo sapiens_hsa050100.71104747
100ABC transporters_Homo sapiens_hsa020100.70470856
101Staphylococcus aureus infection_Homo sapiens_hsa051500.69187522
102Measles_Homo sapiens_hsa051620.68291079
103Influenza A_Homo sapiens_hsa051640.66146556
104Renin secretion_Homo sapiens_hsa049240.64659477
105Fatty acid metabolism_Homo sapiens_hsa012120.64638323
106Toxoplasmosis_Homo sapiens_hsa051450.63876201
107Adipocytokine signaling pathway_Homo sapiens_hsa049200.61116825
108Systemic lupus erythematosus_Homo sapiens_hsa053220.60497145
109Sulfur metabolism_Homo sapiens_hsa009200.59246130
110Rheumatoid arthritis_Homo sapiens_hsa053230.58942174
111Primary immunodeficiency_Homo sapiens_hsa053400.58758551
112Protein digestion and absorption_Homo sapiens_hsa049740.57229456
113NF-kappa B signaling pathway_Homo sapiens_hsa040640.56441033
114Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.56358064
115Salmonella infection_Homo sapiens_hsa051320.53390149
116Tyrosine metabolism_Homo sapiens_hsa003500.51613589
117Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.51515646
118NOD-like receptor signaling pathway_Homo sapiens_hsa046210.51186313
119Histidine metabolism_Homo sapiens_hsa003400.48771132
120Thyroid hormone synthesis_Homo sapiens_hsa049180.47851600
121Circadian rhythm_Homo sapiens_hsa047100.46808696
122Herpes simplex infection_Homo sapiens_hsa051680.45660456
123Pancreatic secretion_Homo sapiens_hsa049720.45591387
124Arginine and proline metabolism_Homo sapiens_hsa003300.44812210
125African trypanosomiasis_Homo sapiens_hsa051430.44605415
126Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.42981093
127Metabolic pathways_Homo sapiens_hsa011000.42914319
128Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.41642614
129Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.41570242
130Vitamin digestion and absorption_Homo sapiens_hsa049770.41351346
131Pyrimidine metabolism_Homo sapiens_hsa002400.40731106
132Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.40130509
133Vascular smooth muscle contraction_Homo sapiens_hsa042700.38069840
134Calcium signaling pathway_Homo sapiens_hsa040200.37776364
135Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.37669974
136Pentose and glucuronate interconversions_Homo sapiens_hsa000400.37262730
137Osteoclast differentiation_Homo sapiens_hsa043800.35644386
138Proteasome_Homo sapiens_hsa030500.35514293
139Graft-versus-host disease_Homo sapiens_hsa053320.35413223
140Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.34640195
141Autoimmune thyroid disease_Homo sapiens_hsa053200.32983297
142Collecting duct acid secretion_Homo sapiens_hsa049660.32668963
143Fatty acid elongation_Homo sapiens_hsa000620.32506581
144Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.32240208
145Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.31795622
146Inositol phosphate metabolism_Homo sapiens_hsa005620.31674355
147TNF signaling pathway_Homo sapiens_hsa046680.29280150
148Phosphatidylinositol signaling system_Homo sapiens_hsa040700.26498762
149Bile secretion_Homo sapiens_hsa049760.25612187
150Taste transduction_Homo sapiens_hsa047420.25571042
151Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.25081050
152Jak-STAT signaling pathway_Homo sapiens_hsa046300.24520081
153B cell receptor signaling pathway_Homo sapiens_hsa046620.24364633
154cGMP-PKG signaling pathway_Homo sapiens_hsa040220.22756836
155Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.22659421
156Estrogen signaling pathway_Homo sapiens_hsa049150.22587202
157Malaria_Homo sapiens_hsa051440.22058519
158Hedgehog signaling pathway_Homo sapiens_hsa043400.21968930

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